徐健，中国科学院青岛生物能源与过程所研究员、所务委员、生物能源部主任、单细胞中心主任、基因组工程团队负责人；山东省能源生物遗传资源重点实验室主任。兼任军委科技委国防创新特区主题专家（2017-2021）、山东省政协委员（2018-2022）、美国微生物物学会会刊mSystems高级编辑。1976年生；1997年北京大学生物技术学士；2003年华盛顿大学计算机科学硕士和生物化学博士；2004-08年于华盛顿大学遗传学系和基因组研究院任基因型组装和分析团队负责人。2008年全职加入中科院青岛生物能源与过程所。论文发表于Science、Cell Host Microbe、Nature Commu. 、Science Adv. 等130余篇，被引近12000次，H-index 50。获首届中组部万人计划（青年拔尖人才，2012；创新领军人才，2019）、国家杰出青年基金（2014）、中国青年科技奖（2015）、中源协和生命医学创新突破奖（2016）、泰山学者、“科技领军人才工作室”（山东省科技厅）等荣誉。

单细胞中心由来自单细胞功能基因组学、合成生物学、微流控科学、生物信息学、光学工程和精密仪器等学科背景的90多位工作人员和研究生组成。我们提出了拉曼组（ramanome）、元拉曼组（metaramanome）等单细胞代谢表型组学概念，研制成功单细胞分析科学仪器系列（全自动单细胞拉曼成像仪、单细胞拉曼药敏快检仪CAST-R、高通量单细胞流式拉曼分选仪FlowRACS、单细胞拉曼分选-测序系统RACS-Seq、模块化单细胞微液滴分选系统EasySort等），开发了单细胞代谢表型组-基因组 (MP-G)n、微生物组大数据引擎（Microbiome Search Engine; www.MSE.ac.cn）等原创的单细胞/元基因组大数据系统与人工智能工具，服务于细胞工厂筛选、生物资源挖掘、海洋生态监控、慢病诊断、抗感染精准用药、肿瘤药物筛选等。同时，单细胞中心是工业微藻合成生物学领域的开拓者之一。我们以微拟球藻为模式，建立了富有特色的光合固碳底盘细胞构建和筛选技术体系，推动了工业微藻的分子育种，服务于第三代生物燃料的生产和人体精准营养。详情见单细胞中心网站 http://www.single-cell.cn ；产品和技术服务请见 青岛星赛生物科技有限公司网站 http://www.singlecellbiotech.com/。 

   

071010-生物化学与分子生物学
071005-微生物学

系统生物学，功能基因组

1997-09--2003-06 华盛顿大学(圣路易斯) 博士学位
1993-09--1997-06 北京大学 学士学位

   

2008-06~现在, 中国科学院青岛生物能源与过程研究所, 研究员
2004-07~2008-05,华盛顿大学基因组测序中心, “序列组装和分析”研究小组创建人和负责人
2003-07~2004-06,华盛顿大学基因组科学中心, 博士后

2015-07-01-今,“mSystems”, 高级编委
2011-01-01-2018-12-31,青岛市生物工程协会副理事长,
2011-01-01-2017-01-31,中国微生物学会国际合作与交流委员会, 委员
2011-01-01-2016-01-31,中国微生物学会分子生物学和生物工程委员会, 委员
2010-12-31-2018-12-31,“Algal Research”编委,
2009-01-01-2011-12-31,“Applied Environmental Microbiology”编委,

   

（1） 中组部万人计划创新领军人才, , 国家级, 2019
（2） 第十四届中国青年科技奖, 国家级, 2016
（3） 首届中源协和生命医学奖-创新突破奖, 其他, 2016
（4） 国家杰出青年基金（2014）, , 国家级, 2014
（5） 2013年中科院百篇优秀博士论文（作为导师）, , 院级, 2013
（6） 科技部中青年科技创新领军人才推进计划（2013）, , 部委级, 2013
（7） 首届中组部万人计划青年拔尖人才计划（2012）, , 国家级, 2012

[1] 荆晓艳, 潘慧慧, 孟宇, 籍月彤, 徐健. 一种富集污水微生物以用于单细胞精度表型测量和分选的试剂盒及方法. CN: CN113186100A, 2021-07-30.

[2] 李远东, 阚凌雁, 任立辉, 籍月彤, 马波, 徐健. 耦合装置及显微-光镊单细胞分选系统和其分选方法. CN: CN113136324A, 2021-07-20.

[3] 马波, 刁志钿, 王喜先, 徐腾, 徐健. 基于光热效应进行微量液滴操控的微流控芯片及方法. CN: CN112871227A, 2021-06-01.

[4] 马波, 徐健, 王喜先, 任立辉, 籍月彤. 一种拉曼激活液滴分选系统和方法. CN: CN109706053B, 2021-04-23.

[5] 魏力, 辛一, 王勤涛, 徐健. 一种用于微拟球藻基因沉默的RNAi载体及其应用. CN: CN107236756B, 2021-04-23.

[6] 何曰辉, 籍月彤, 徐健. 一种含色素细胞样品的非色素拉曼信号采集的方法. CN: CN112557370A, 2021-03-26.

[7] 许成钢, 王艺霖, 滕琳, 徐健. 一种原核细胞转录后水平控制不同基因表达比例的方法. CN: CN107841510B, 2021-02-09.

[8] 马波, 徐腾, 籍月彤, 徐健. 一种针对低浓度液体样本的离心富集微流控芯片. CN: CN112076806A, 2020-12-15.

[9] 马波, 刘沣仪, 徐腾, 徐健. 一种自发形成油包水液滴的微流控芯片及装置. CN: CN112076807A, 2020-12-15.

[10] 张佳, 柴百惠, 徐健. 一种错配结合蛋白的突变体及其编码基因. CN: CN112079903A, 2020-12-15.

[11] 徐健, 朱鹏飞, 戴靖, 籍月彤, 马波. 一种单细胞拉曼临床耐药性试剂盒及检测方法. CN: CN112080545A, 2020-12-15.

[12] 李远东, 阚凌雁, 任立辉, 籍月彤, 马波, 徐健. 耦合装置及显微-光镊单细胞分选系统. CN: CN212077049U, 2020-12-04.

[13] 徐健, 陶一帆, 王允, 黄适, 凌均棨. 一种快速定性/定量评价不同抗菌药物作用效果的方法. CN: CN112014372A, 2020-12-01.

[14] 徐腾, 马波, 徐健. 单个微粒包裹液滴在微流控芯片中形成并分别导出的方法. CN: CN109772480B, 2020-11-10.

[15] 徐健, 陶一帆, 王允, 黄适, 凌均棨. 一种快速定量评价不同抗菌药物作用效果的方法. CN: CN108459001B, 2020-10-27.

[16] 许成钢, 滕琳, 徐健. 一种厌氧梭菌木聚糖诱导型启动子及其应用. CN: CN106554961B, 2020-04-24.

[17] 许成钢, 滕琳, 徐健. 一种厌氧梭菌组成型高效表达启动子及其应用. CN: CN106554960B, 2020-04-24.

[18] 孙政, 朱鹏飞, 黄适, 徐健. 一种基于共生菌群的皮肤亚健康和药物敏感性检测系统. CN: CN110804666A, 2020-02-18.

[19] 任立辉, 李远东, 聂亚茹, 马雪贇, 籍月彤, 马波, 徐健. 基于单细胞检测的高通量并行拉曼光谱仪. CN: CN110687089A, 2020-01-14.

[20] 李春宇, 马波, 徐健. 一种模块化微流控芯片的制作方法. CN: CN107774348B, 2019-11-26.

[21] 李春宇, 马波, 徐健. 一种微流控动态液滴操控的方法及其动态液滴平台. CN: CN107774347B, 2019-11-26.

[22] 辛一, 徐健. 一种具有甘油三酯（TAG）合成功能的基因及其构建方法和应用. CN: CN110305883A, 2019-10-08.

[23] 勾洪磊, 荆晓艳, 籍月彤, 徐健. 一种单细胞激光弹射基片、方法及应用. CN: CN110042053A, 2019-07-23.

[24] 徐健, 辛一, 路延笃. 一种具有三脂酰甘油合成功能的基因及其应用. CN: CN105255912B, 2019-07-12.

[25] 勾洪磊, 葛亮皓, 王乙潜, 徐健. 一种细菌鉴别的方法. CN: CN109696431A, 2019-04-30.

[26] 勾洪磊, 籍月彤, 徐健. 一种用于单细胞拉曼测量和激光显微切割的一体化分选装置. CN: CN109557068A, 2019-04-02.

[27] L.富拉格, F.劳费尔, H.施特鲁布, 王允, 徐健, 徐卉芳, 李盛英. α-烯烃的生产. 中国: CN108779476A, 2018.11.09.

[28] 周茜, 宁康, 苏晓泉, 徐健. 基于多核CPU硬件的高通量转录组测序数据质量控制方法. 中国: CN105095686B, 2018-08-14.

[29] 任立辉, 宁康, 苏晓泉, 徐健, 肖航. 活体单细胞拉曼分析平台数字控制系统和方法. 中国: CN105588827B, 2018-07-24.

[30] 辛一, 徐健. 具有三脂酰甘油合成功能的基因及其在理性调控产油微藻三脂酰甘油含量或饱和度中的应用. 中国: CN108220306A, 2018-06-29.

[31] 勾洪磊, 荆晓艳, 苏晓璐, 籍月彤, 徐健. 一种用于单细胞快速拉曼测量和激光弹射分选的一体化装置. 中国: CN107589105A, 2018-01-16.

[32] 魏力, 王勤涛, 辛一, 徐健. 一种编码叶绿体碳酸酐酶基因在构建耐高浓度CO 2 且快速生长的工业工程微藻中的应用. 中国: CN106995817A, 2017.08.01.

[33] 勾洪磊, 籍月彤, 徐健. 一种高通量微生物单细胞自动化分选及接收系统. 中国: CN107490545A, 2017-12-19.

[34] 马波, 张强, 徐健. 一种低成本、高效分离获取单细胞的系统和方法. 中国: CN104877898B, 2017-12-15.

[35] 徐健, 王险, 魏力. 一种检测微藻挥发油成分的方法. 中国: CN107449833A, 2017-12-08.

[36] 马波, 张沛然, 徐健, 张旭. 一种捕获采集细胞/颗粒拉曼光谱的微流控芯片及方法. 中国: CN104677877B, 2017-11-28.

[37] 滕飞, 杨芳, 黄适, 徐健. 一种筛选婴幼儿龋病的口腔致病性生物标记物的方法. 中国: CN106446599A, 2017-02-22.

[38] 任立辉, 滕琳, 王晓君, 苏晓泉, 徐健. 基于单细胞表现型数据库的表型数据分析处理方法. 中国: CN106295251A, 2017-01-04.

[39] 滕飞, 杨芳, 黄适, 凌均棨, 徐健. 口腔微生物群落检测模型的构建方法及其应用. 中国: CN106202846A, 2016-12-07.

[40] 滕飞, 杨芳, 黄适, 徐健. 一种基于口腔微生物群落获得儿童个体生物年龄的方法. 中国: CN106202989A, 2016-12-07.

[41] 马波, 单宇飞, 任立辉, 徐健. 一种基于微流芯片与智能手机的快速活菌计数系统. 中国: CN106148177A, 2016-11-23.

[42] 张旭, 马波, 徐健, 罗娅君. 一种快速生长微藻藻株高通量筛选系统和方法. 中国: CN106148159A, 2016-11-23.

[43] 路延笃, 徐健. 一种可以调控微藻生长和其它功能的生长调节剂及其鉴定方法和应用. 中国: CN104946535A, 2015.09.30.

[44] 徐健, 滕琳, 籍月彤, 黄巍. 一种快速区分环境中刺激（污染）物质的方法. 中国: CN104515763A, 2015.04.15.

[45] 李春宇, 马波, 徐健. 一种基于亲水纤维丝诱导的微液滴融合方法. 中国: CN105013544A, 2015-11-04.

[46] 宁康, 胡建强, 苏晓泉, 徐健. 一种利用DNA进行信息存储的编码方法和解码方法. 中国: CN105022935A, 2015-11-04.

[47] 马波, 张旭, 徐健. 一种基于液滴的微生物快速直接绝对定量检测系统和方法. 中国: CN104877899A, 2015-09-02.

[48] 宁康, 白虹, 苏晓泉, 程新玮, 赵焕新, 徐健, 陈晓华. 一种基于高通量测序技术的中药制剂生物成分分析方法. 中国: CN104673881A, 2015-06-03.

[49] 马波, 张沛然, 徐健, 张旭. 一种基于压力吸吮的细胞/颗粒分选系统和方法. 中国: CN104677808A, 2015-06-03.

[50] 李春宇, 马波, 徐健. 一种基于自供能真空微泵的便携式微液滴发生器. 中国: CN104415801A, 2015-03-18.

[51] 徐健, 魏力, 路延笃. 一种微藻培养反应器. 中国: CN104109631A, 2014.10.22.

[52] 任立辉, 宁康, 籍月彤, 王允, 徐健, 黄巍. 单细胞表现型数据库系统和搜索引擎. 中国: CN104077307A, 2014-10-01.

[53] 徐健, 何曰辉, 籍月彤, 王婷婷, 王允, 黄巍. 一种单细胞水平快速鉴定微藻的方法. 中国: CN103940801A, 2014-07-23.

[54] 任立辉, 宁康, 马波, 徐健, 黄巍. 活体单细胞分选电子控制系统. 中国: CN103897985A, 2014-07-02.

[55] 路延笃, 徐健, 辛一, 魏力. 一种向微拟球藻叶绿体中导入外源DNA的方法及相关的叶绿体基因组序列. 中国: CN103834640A, 2014-06-04.

[56] 周茜, 宁康, 苏晓泉, 徐健. 基于多核CPU和GPGPU硬件的高通量测序数据质量控制系统. 中国: CN103838985A, 2014-06-04.

[57] 籍月彤, 王婷婷, 王允, 何曰辉, 黄巍, 徐健. 一种快速检测微藻产能过程的方法. 中国: CN103592283A, 2014-02-19.

[58] 徐健, 林璐, 秦勇, 宋厚辉. 一种提高微生物底物利用率的发酵方法. 中国: CN102286598A, 2011-12-21.

[59] 徐健, 秦勇, 李玉东, 宋厚辉, 黄建忠. 一种发酵合成气生产有机酸或醇的方法及装置. 中国: CN102094048A, 2011-06-15.

[60] 宋厚辉, 黄巍, 林璐, 徐健. 一种细胞遗传转化的方法和装置. 中国: CN101948825A, 2011-01-19.

[61] 徐健, 杨芳, 凌均棨, 曾晓维, 王玮, 宋厚辉. 一种口腔微生物群落数据库及其应用. 中国: CN101833613A, 2010.09.15.

[62] 宋厚辉, 林璐, 黄巍, 徐健. 一种超声波介导的微生物遗传转化方法及其应用. 中国: CN101875947A, 2010-11-03.

   

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[2] Wang, Qintao, Gong, Yanhai, He, Yuehui, Xin, Yi, Lv, Nana, Du, Xuefeng, Li, Yun, Jeong, ByeongRyool, Xu, Jian. Genome engineering of Nannochloropsis with hundred-kilobase fragment deletions by Cas9 cleavages. PLANT JOURNAL[J]. 2021, 106(4): 1148-1162, http://dx.doi.org/10.1111/tpj.15227.
[3] He, Yuehui, Huang, Shi, Zhang, Peng, Ji, Yuetong, Xu, Jian. Intra-Ramanome Correlation Analysis Unveils Metabolite Conversion Network from an Isogenic Population of Cells. MBIO[J]. 2021, 12(4): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000694734900003.
[4] Bhaskar, Yogendra, Su, Xiaoquan, Xu, Chenggang, Xu, Jian. Predicting Selective RNA Processing and Stabilization Operons in Clostridium spp.. FRONTIERS IN MICROBIOLOGY[J]. 2021, 12: http://dx.doi.org/10.3389/fmicb.2021.673349.
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（ 1 ） 微拟球藻制备生物柴油之全基因组学研究模式的构建, 主持, 国家级, 2011-01--2013-12
（ 2 ） 嗜热厌氧乙醇杆菌X514菌株乙醇耐受性之相关遗传因子的发现, 主持, 国家级, 2009-01--2011-12
（ 3 ） 纤维素生物降解中梭菌纤维小体的人为设计与构建, 主持, 国家级, 2010-12--2012-12
（ 4 ） 基于新一代测序技术的元基因组数据采集和分析系统, 参与, 国家级, 2009-01--2011-12
（ 5 ） 热纤梭菌的遗传改造和混合发酵, 主持, 国家级, 2008-01--2011-12
（ 6 ） 能源微藻与生物炼制, 主持, 国家级, 2009-04--2013-04
（ 7 ） 嗜热厌氧产乙醇菌的系统生物学改造技术研究, 主持, 省级, 2008-12--2011-12
（ 8 ） 秸秆固态酶解发酵生产燃料乙醇关键技术及示范, 参与, 国家级, 2011-01--2013-12
（ 9 ） 拉曼光钳筛选新方法在活体单细胞高通量分离中的应用, 主持, 国家级, 2011-06--2012-06
（ 10 ） 服务于新一代微生物群落元基因组研究的e-Science示范应用, 主持, 国家级, 2009-01--2010-12
（ 11 ） 自然界复杂多糖的微生物降解多样性及机制, 主持, 国家级, 2008-01--2010-12
（ 12 ） 能源微藻资源筛选与规模化利用之平台建设, 主持, 国家级, 2009-01--2009-12
（ 13 ） 单细胞功能基因组分析与自动培养系统研制, 主持, 国家级, 2012-11--2014-10
（ 14 ） 微藻中淀粉与油脂合成的诱导原理及其高效控制方法, 主持, 国家级, 2013-01--2015-12
（ 15 ） 生物高通量检测分析服务网络, 主持, 部委级, 2016-01--2017-12
（ 16 ） 微生物功能基因组学, 主持, 国家级, 2015-01--2018-12
（ 17 ） 土壤微生物单细胞筛选的新技术及应用, 主持, 部委级, 2014-07--2018-12
（ 18 ） 单细胞遗传分析仪研制, 主持, 国家级, 2014-01--2017-12
（ 19 ） 单细胞尺度的嗜热细菌微进化研究, 主持, 国家级, 2013-01--2016-12
（ 20 ） 基因组网络分析与功能模块设计, 主持, 国家级, 2012-01--2016-08
（ 21 ） 单细胞三维生化成像与遗传分析系统, 主持, 部委级, 2016-08--2020-12
（ 22 ） 宽光谱利用及强光驱动CO2转化：蔗糖, 参与, 部委级, 2016-01--2018-12
（ 23 ） “微生物组大数据搜索引擎”关键技术与应用示范, 主持, 省级, 2016-11--2019-12
（ 24 ） 基于人体共生菌群的中国国民营养与粮食需求研究, 主持, 部委级, 2016-12--2017-12
（ 25 ） 单细胞拉曼耐药性快检仪, 主持, 国家级, 2019-01--2023-12
（ 26 ） 微生物组功能解析技术与计算方法学, 主持, 部委级, 2017-08--2019-07
（ 27 ） 病原菌拉曼指纹图谱和病原菌单细胞生物学, 参与, 部委级, 2018-07--2022-07
（ 28 ） 单细胞精度的菌群“代谢表型组-基因组”方法学研究, 主持, 国家级, 2021-01--2025-12

已指导学生

林璐  博士研究生  071010-生物化学与分子生物学  

李敬  博士研究生  071010-生物化学与分子生物学  

黄冉冉  博士研究生  071010-生物化学与分子生物学  

魏力  博士研究生  071010-生物化学与分子生物学  

辛一  博士研究生  071010-生物化学与分子生物学  

加晶  博士研究生  071010-生物化学与分子生物学  

何曰辉  硕士研究生  085238-生物工程  

滕琳  博士研究生  071010-生物化学与分子生物学  

黄适  博士研究生  071010-生物化学与分子生物学  

胡建强  硕士研究生  071010-生物化学与分子生物学  

王勤涛  博士研究生  071010-生物化学与分子生物学  

王险  硕士研究生  081703-生物化工  

张鹏  博士研究生  071010-生物化学与分子生物学  

荆晓艳  博士研究生  071010-生物化学与分子生物学  

何曰辉  博士研究生  071010-生物化学与分子生物学  

孙政  博士研究生  071010-生物化学与分子生物学  

苏晓泉  博士研究生  071005-微生物学  

佘依婷  硕士研究生  085238-生物工程  

现指导学生

梁文思  博士研究生  071005-微生物学  

陈荣泽  博士研究生  071005-微生物学  

徐腾  博士研究生  071005-微生物学  

李贞  硕士研究生  085238-生物工程  

王建美  博士研究生  071005-微生物学