Ling CHEN 陈凌  
Principal Investigator, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science;
Standing Deputy Director General, State Key Laboratory of Respiratory Disease;
Telephone: 020-32015289
Address: 190#, Kaiyuan Avenue, Science park, Huangpu District, Guangzhou, Guangdong, China
Postcode: 501530

Research Areas

Research areas include
HIV Vaccine;
Influenza research;
New technologies for antibody discovery and vaccine delivery.


1992-01--1994-06 Postdoc at Harvard Medical School & DFCI
1985-09--1991-12 Ph.D. School of Medicine, Indiana University, USA
1979-09--1985-06 Shanghai First Medical College (Fudan university)


Work Experience
2004.03-so far Principal Investigator, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science
2012.08-so far Standing Deputy Director General of State Key Laboratory of Respiratory Disease
2012.01-2012.07 Sanofi Pasteur, VP of R&D
2008.08-2011.12 GlaxoSmithKline, VP of R&D
2006 National Science Fund for Outstanding Young Scholars
2004.01-2008. 07 Founding Director General of GIBH
2001.03-2003.12 Lexicon Genetics Inc, Director of Biophama department
1997.01-2001.04 Merck Research Laboratories,Senior Research Fellow
1994.01-1996.12 Harvard Medical School, Instructor


1. Zhi, H., L. Qu, F. Wu, L. Chen and J. Tao. "Group Iie Secretory Phospholipase A2 Regulates Lipolysis in Adipocytes." Obesity (Silver Spring) 23, no. 4 (2015): 760-8.
2. Zhang, Y., L. Feng, L. Li, D. Wang, C. Li, C. Sun, P. Li, X. Zheng, Y. Liu, W. Yang, X. Niu, N. Zhong and L. Chen. "Effects of the Fusion Design and Immunization Route on the Immunogenicity of Ag85a-Mtb32 in Adenoviral Vectored Tuberculosis Vaccine." Hum Vaccin Immunother 11, no. 7 (2015): 1803-13.
3. Jin, Y., C. Sun, L. Feng, P. Li, L. Xiao, Y. Ren, D. Wang, C. Li and L. Chen. "Regulation of Siv Antigen-Specific Cd4+ T Cellular Immunity Via Autophagosome-Mediated Mhc Ii Molecule-Targeting Antigen Presentation in Mice." PLoS One 9, no. 3 (2014): e93143.
4. Pan, W., L. Han, Z. Dong, X. Niu, Z. Li, L. Bao, C. Li, Q. Luo, Z. Yang, X. Li, J. Huang, L. Feng, C. Qin, N. Zhong and L. Chen. "Induction of Neutralizing Antibodies to Influenza a Virus H7n9 by Inactivated Whole Virus in Mice and Nonhuman Primates." Antiviral Res 107, (2014): 1-5.
5. Xiao, L. J., D. M. Wang, P. C. Li, Y. Jin, L. Q. Feng, C. J. Sun and L. Chen. "Enhancement of Siv-Specific Cell Mediated Immune Responses by Co-Administration of Soluble Pd-1 and Tim-3 as Molecular Adjuvants in Mice." Human Vaccines & Immunotherapeutics 10, no. 3 (2014): 724-733.
6. Meng, W., W. Pan, A. J. Zhang, Z. Li, G. Wei, L. Feng, Z. Dong, C. Li, X. Hu, C. Sun, Q. Luo, K. Y. Yuen, N. Zhong and L. Chen. "Rapid Generation of Human-Like Neutralizing Monoclonal Antibodies in Urgent Preparedness for Influenza Pandemics and Virulent Infectious Diseases." PLoS One 8, no. 6 (2013): e66276.
7. Pan, W., Z. Dong, F. Li, W. Meng, L. Feng, X. Niu, C. Li, Q. Luo, Z. Li, C. Sun and L. Chen. "Visualizing Influenza Virus Infection in Living Mice." Nat Commun 4, (2013): 2369.
8. Sun, C., Z. Chen, X. Tang, Y. Zhang, L. Feng, Y. Du, L. Xiao, L. Liu, W. Zhu, L. Chen and L. Zhang. "Mucosal Priming with a Replicating-Vaccinia Virus-Based Vaccine Elicits Protective Immunity to Simian Immunodeficiency Virus Challenge in Rhesus Monkeys." J Virol 87, no. 10 (2013): 5669-77.
9. Zhang, Y., C. Sun, L. Feng, L. Xiao and L. Chen. "Enhancement of Gag-Specific but Reduction of Env- and Pol-Specific Cd8+ T Cell Responses by Simian Immunodeficiency Virus Nonstructural Proteins in Mice." AIDS Res Hum Retroviruses 28, no. 4 (2012): 374-83.
10. Sun, C., Y. Zhang, L. Feng, W. Pan, M. Zhang, Z. Hong, X. Ma, X. Chen and L. Chen. "Epidemiology of Adenovirus Type 5 Neutralizing Antibodies in Healthy People and Aids Patients in Guangzhou, Southern China." Vaccine 29, no. 22 (2011): 3837-41.
11. Guan, M., L. Qu, W. Tan, L. Chen and C. W. Wong. "Hepatocyte Nuclear Factor-4 Alpha Regulates Liver Triglyceride Metabolism in Part through Secreted Phospholipase a(2) Gxiib." Hepatology 53, no. 2 (2011): 458-66.
12. Sun, C., Y. Zhang, Y. Liu, M. Zhang and L. Chen. "Short Communication: Enhancement of Immunogenicity of Replication-Defective Adenovirus-Based Human Immunodeficiency Virus Vaccines in Rhesus Monkeys." AIDS Res Hum Retroviruses 27, no. 6 (2011): 681-6.
13. Hu, X., W. Meng, Z. Dong, W. Pan, C. Sun and L. Chen. "Comparative Immunogenicity of Recombinant Adenovirus-Vectored Vaccines Expressing Different Forms of Hemagglutinin (Ha) Proteins from the H5 Serotype of Influenza a Viruses in Mice." Virus Res 155, no. 1 (2011): 156-62.
14. Jiang, B., L. Qin, Y. Du, N. Peng, L. Chen, Z. Chen and X. Chen. "Transgenic Plasmodium That Expresses Hiv-1 Gag Elicits Immunity and Protects Mice against Vaccinia Virus-Gag and Malarial Parasites." Vaccine 28, no. 50 (2010): 7915-22.
15. Hu, W., S. Zeng, C. Li, Y. Jie, Z. Li and L. Chen. "Identification of Hits as Matrix-2 Protein Inhibitors through the Focused Screening of a Small Primary Amine Library." J Med Chem 53, no. 9 (2010): 3831-4.
16. Zhong, M., X. Ma, C. Sun and L. Chen. "Micrornas Reduce Tumor Growth and Contribute to Enhance Cytotoxicity Induced by Gefitinib in Non-Small Cell Lung Cancer." Chem Biol Interact 184, no. 3 (2010): 431-8.
17. Xu, W., L. Yi, Y. Feng, L. Chen and J. Liu. "Structural Insight into the Activation Mechanism of Human Pancreatic Prophospholipase A2." J Biol Chem 284, no. 24 (2009): 16659-66.
18. Li, F., L. Feng, Y. Liu, X. Zhen and L. Chen. "An Integrated Cell Culture and Quantitative Polymerase Chain Reaction Technique for Determining Titers of Functional and Infectious Adenoviruses." Anal Biochem 391, no. 2 (2009): 157-9.
19. Ma, X., L. H. Tang, L. B. Qu, J. Ma and L. Chen. "Identification of 17 Novel Major Histocompatibility Complex-a Alleles in a Population of Chinese-Origin Rhesus Macaques." Tissue Antigens 73, no. 2 (2009): 184-7.
20. Feng, L., F. Li, Y. Liu, X. Zheng, B. Zhang and L. Chen. "A Convenient Plasmid-Based System Containing Three Reporter Genes for Real-Time and Quantitative Analysis of Messenger Rna Silencing." Anal Biochem 394, no. 2 (2009): 284-6.
21. Feng, L., F. Li, X. Zheng, W. Pan, K. Zhou, Y. Liu, H. He and L. Chen. "The Mouse Pol I Terminator Is More Efficient Than the Hepatitis Delta Virus Ribozyme in Generating Influenza-Virus-Like Rnas with Precise 3' Ends in a Plasmid-Only-Based Virus Rescue System." Arch Virol 154, no. 7 (2009): 1151-6.
1. 陈凌,陈志伟,张林琦,孙彩军. 联合使用痘病毒载体HIV疫苗与腺病毒载体HIV疫苗的方法及其应用PCT/CN2010/076905
2. 陈凌,陈志伟,张林琦,孙彩军. 联合使用痘病毒载体HIV疫苗与腺病毒载体HIV疫苗的方法及其应用. 200910192351.6/ CN 101670102 A
3. 陈凌、冯立强、孙彩军、秦成峰. 复制型重组人55型腺病毒载体及其制备方法和应用. 201410293359.2
4. 孙彩军,陈凌,靳怡. 一种引发强效CD4+T细胞免疫反应的新型HIV疫苗. 200910036668
5. 孙彩军,陈凌. 克服预存免疫反应对腺病毒载体产品不利影响的方法及其应用. 200910036668
6. 陈凌,李楚芳,徐伟,肖益平,杨令芝. 用于流感病毒M2离子通道阻断剂筛选的荧光细胞模型及其应用方法. 200910036424.2
7. 李峰,冯立强,陈凌. 一种NA片段携带外源基因的重组流感病毒载体及其制备方法和应用 . 200910038838.9
8. 陈凌,李峰,潘蔚绮,杨化强. 一种流感病毒疫苗种子株的制备方法. 200810029130.2
9. 陈凌,李峰. 互补型高容量腺病毒载体系统及其构建的疫苗和基因治疗产品. 200710026571.2/ CN 101363028 A
10. 陈凌,马鑫. 携带HIV基因的腺病毒载体疫苗. ZL 2007 1 0026295.X

Research Interests

Our lab main focused on HIV and respiratory diseases, such as influenza virus, adenovirus, Ebola and so on.