基本信息
郭非凡  女  博导  中国科学院上海营养与健康研究所
电子邮件: ffguo@sibs.ac.cn
通信地址: 上海市岳阳路320号新生命科学大楼
邮政编码: 200032

招生信息

   
招生专业
071003-生理学
100104-病理学与病理生理学
086000-生物与医药
招生方向
生理学-营养代谢的遗传与营养调控研究
病理学与病理生理学-营营养代谢的遗传与营养调控研究
生物与医药-营养代谢的遗传与营养调控研究

教育背景

2002-09--2005-05   美国哈佛大学医学院Beth Israel Deaconess医学中心   博士后
2001-09--2002-08   美国明尼苏达州立大学   博士后
1997-05--2001-08   日本东京大学神经生化学   博 士
1992-09--1995-07   大连医科大学病理生理学   硕 士
1987-09--1992-07   大连医科大学临床医学系   学 士

工作经历

   
工作简历
2007-08~现在, 中国科学院上海生命科学研究院, 研究员、教授、博导
2005-06~2007-08,美国宾州州立大学, 研究助理教授
2002-09~2005-05,美国哈佛大学医学院Beth Israel Deaconess医学中心, 博士后
2001-09~2002-08,美国明尼苏达州立大学, 博士后
1997-05~2001-08,日本东京大学神经生化学, 博 士
1992-09~1995-07,大连医科大学病理生理学, 硕 士
1987-09~1992-07,大连医科大学临床医学系, 学 士
社会兼职
2019-05-11-今,中国生物物理学会代谢生物学分会, 理事
2018-10-01-2022-10-01,中国生物化学与分子生物学会第十二届理事会, 理事
2016-07-01-今,中国病理生理学会内分泌与代谢专业委员会(筹), 副主任委员

教授课程

营养学

专利与奖励

   
奖励信息
(1) 上海市优秀学术带头人, 一等奖, 省级, 2017
(2) 上海市三八红旗手, 一等奖, 省级, 2016
(3) 上海市自然科学三等奖, 三等奖, 省级, 2015
(4) 中国科学院“****”终期评估优秀, 一等奖, 院级, 2013
(5) 美国内分泌学会奖, , 专项, 2004
(6) 美国甲状腺学会奖, , 专项, 2003
专利成果
( 1 ) 一种防治胰岛素抵抗及其相关疾病的新靶标, 2016, 第 1 作者, 专利号: ZL 2012010289347.3

( 2 ) PSAT1及其产物在制备调节胰岛素敏感性的药物中的用途, 2014, 第 1 作者, 专利号: 201410727689.8

( 3 ) 一种特殊食物对减肥的显著作用, 2010, 第 1 作者, 专利号: 12/004,518

出版信息

   
发表论文
(1) Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals., Molecular Metabolism, 2019, 通讯作者
(2) ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides., Gastroenterology, 2019, 通讯作者
(3) SGK1/FOXO3 Signaling in Hypothalamic POMC Neurons Mediates Glucocorticoid-Increased Adiposity., Diabetes, 2018, 通讯作者
(4) miR-212-5p suppresses lipid accumulation by targeting FAS and SCD1., J Mol Endocrinol, 2017, 通讯作者
(5) An ATF4-ATG5 signaling in hypothalamic POMC neurons regulates obesity., Autophagy, 2017, 通讯作者
(6) An ATF4/ATG5 signaling in hypothalamic POMC neurons regulates fat mass via affecting energy expenditure., Diabetes, 2017, 通讯作者
(7) Deletion of ATF4 in AgRP neurons promotes fat loss mainly via increasing energy expenditure., Diabetes, 2017, 通讯作者
(8) Effects of essential amino acids on lipid metabolism in mice and humans., Journal of Molecular Endocrinology, 2016, 通讯作者
(9) Liver-specific Gene Inactivation of the Transcription Factor ATF4 Alleviates Alcoholic Liver Steatosis in Mice., The Journal of Biological Chemistry, 2016, 通讯作者
(10) Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy., Open Biology, 2016, 通讯作者
(11) Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase., Oncotarget, 2016, 通讯作者
(12) Guo Y#, Yu J#, Deng J, Liu B, Xiao Y, Li K, Xiao F, Yuan F, Liu Y, Chen S, and Guo F*. A Novel Function of Hepatic FOG2 in Insulin Sensitivity and Lipid Metabolism Through Peroxisome Proliferator–Activated Receptor alpha., Diabetes, 2016, 通讯作者
(13) Xiao F#, Deng J#, Guo Y, Niu Y, Yuan F, Yu J, Chen S, Guo F*. BTG1 ameliorates liver steatosis by decreasing stearoyl-CoA desaturase 1 (SCD1) abundance and altering hepatic lipid metabolism., Science Signaling, 2016, 通讯作者
(14) Xiao F, Deng J, Yu J, Guo Y, Chen S, and Guo F*. A novel function of B-cell translocation gene 1 (BTG1) in the regulation of hepatic insulin sensitivity in mice via c-Jun., The FASEB Journal, 2016, 通讯作者
(15) Xiao Y#, Liu H#, Yu J, Zhao Z, Xiao F, Xia T, Wang C, Li K, Deng J, Guo Y, Chen S, Chen Y and Guo F*. Activation of ERK1/2 ameliorates liver steatosis in leptin receptor deficient (db/db)mice via stimulating ATG7-dependent autophagy, Diabetes, 2016, 通讯作者
(16) Xiao Y#, Liu H#, Yu J, Zhao Z, Xiao F, Xia T, Wang C, Li K, Deng J, Guo Y, Chen S, Chen Y and Guo F*. MAPK1/3 regulate hepatic lipid metabolism via ATG7-dependent autophagy., Autophagy, 2016, 通讯作者
(17) Yu J, Xiao F, Guo Y, Deng J, Liu B, Zhang Q, Li K, Wang C, Chen S, and Guo F*. Hepatic phosphoserine aminotransferase 1 (PSAT1) regulates insulin sensitivity in mice via tribbles homolog 3 (TRB)., Diabetes, 2015, 通讯作者
(18) Xia T#, Zhang Q#, Xiao Y, Wang C, Yu J, Liu H, Liu B, Zhang Y, Chen S, Liu Y, Chen Y, and Guo F*. CREB/TRH pathway in the central nervous system regulates energy expenditure in response to deprivation of an essential amino acid., International Journal of Obesity, 2015, 通讯作者
(19) Li K, Zhang J, Yu J, Liu B, Guo Y, Deng J, Chen S, Wang C* and Guo F*. MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4., The Journal of Biological Chemistry, 2015, 通讯作者
(20) Xia T#, Zhang Q#, Xiao Y, Wang C, Yu J, Liu H, Liu B, Zhang Y, Chen S, Liu Y, Chen Y and Guo F*. CREB/TRH pathway in the central nervous system regulates energy expenditure in response to deprivation of an essential amino acid, International Journal of Obesity, 2014, 通讯作者
(21) Xiao F, Yu J, Liu B, Guo Y, Li K, Deng J, Zhang J, Wang C, Chen S, Du Y, Lu Y, Xiao Y, Zhang Z, and Guo F*. A Novel Function of MicroRNA 130a-3p in Hepatic Insulin Sensitivity and Liver Steatosis, Diabetes, 2014, 通讯作者
(22) Xiao F, Yu J, Guo Y, Deng J, Li K, Du Y, Chen S, Zhu J*, Sheng H* and Guo F*. Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice, Metabolism-Clinical and Experimental, 2014, 通讯作者
(23) Wang C#, Li H#, Meng Q#, Du Y, Xiao F, Zhang Q, Yu J, Li K, Chen S, Huang Z, Liu B, and Guo F*. ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression, Journal of Cellular and Molecular Medicine, 2014, 通讯作者
(24) Zhang Q, Liu B, Cheng Y, Meng Q, Xia T, Jiang L, Chen S, Liu Y*, and Guo F*. Leptin signaling is required for leucine deprivation-enhanced energy expenditure., The Journal of Biological Chemistry, 2014, 通讯作者
(25) 8.Xiao F#, Xia T#, Lv Z#, Zhang Q, Xiao Y, Yu J, Liu H, Deng J, Guo Y, Wang C, Li K, Liu B, Chen S, and Guo F*. Central prolactin receptors (PRLRs) regulate hepatic insulin sensitivity in mice via signal transducer and activator of transcription 5 (STAT5) and the vagus nerve., Diabetologia, 2014, 通讯作者
(26) 7.Liu H#, Yu J#, Xia T, Xiao Y, Zhang Q, Liu B, Guo Y, Deng J, Deng Y, Chen S, Aniko Naray-Fejes-Toth†,Geza Fejes-Toth†, and Guo F*. Hepatic serum- and glucocorticoid-induced protein kinase 1 (SGK1) regulates insulin sensitivity in mice via ERK1/2, Biochemical Journal, 2014, 通讯作者
(27) Yu J#, Xiao F#, Zhang Q, Liu B, Guo Y, Lv Z, Xia T, Chen S, Li K, Du Y, and Guo F*. Prolactin Receptor (PRLR) regulates hepatic insulin sensitivity in mice via Signal Transducer and Activator of Transcription (STAT)5, Diabetes, 2013, 通讯作者
(28) Zhang Q, Yu J, Lv Z, Liu B, Xia T, Xiao F, Chen S, and Guo F*. Central activating transcription factor (ATF4) regulates hepatic insulin resistance in mice via S6K1 signaling and the vagus nerve, Diabetes, 2013, 通讯作者
(29) Wang C, Xia T, Du Y, Meng Q, Li H, Liu B, Chen S, and Guo F*. Effects of ATF4 on PGC1? expression in brown adipose tissue and metabolic responses to cold stress, Metabolism-clinical and experimental, 2013, 通讯作者
(30) Xia T, Cheng Y, Zhang Q, Xiao F, Liu B, Chen S, and Guo F*. S6K1 in the central nervous system regulates energy expenditure via MC4R/corticotrophin -releasing hormone pathways in response to deprivation of an essential amino acid, Diabetes, 2012, 通讯作者
(31) Du Y, Meng Q, Zhang Q, and Guo F*. Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT, Amino Acids., 2012, 通讯作者
(32) Qian Zhang, Houkai Li and Feifan Guo*. Amygdala, an important regulator for food intake (INVITED Review), Frontiers in Biology, 2011, 通讯作者
(33) Xiao F, Huang Z, Li H, Yu J, Wang C, Chen S, Meng Q, Cheng Y, Gao X, Li J, Liu Y, and Guo F*. Leucine Deprivation Increases Hepatic Insulin Sensitivity Via GCN2/mTOR/S6K1 and AMPK Pathways, Diabetes, 2011, 通讯作者
(34) Li H, Meng Q, Xiao F, Chen S, Yu J, Wang C, and Guo F*. ATF4 deficiency protects mice from high-carbohydrate diet-induced liver steatosis, Biochemical Journal, 2011, 通讯作者
(35) Cheng Y#, Zhang Q #, Meng Q, Xia T, Huang Z, Wang C, Liu B, Chen S, Xiao F, Du Y, and Guo F*. Leucine Deprivation Stimulates Fat Loss via Increasing CRH Expression in The Hypothalamus and Activating The Sympathetic Nervous System, Molecular Endocrinology, 2011, 通讯作者
(36) Wang C, Huang Z, Du Y, Cheng Y, Chen S, Guo F*. ATF4 regulates lipid metabolism and thermogenesis, Cell Research, 2010, 通讯作者
(37) Cheng Y, Meng Q(co-first author), Wang C, Li H, Huang Z, Chen S, Xiao F, Guo F*. Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue, Diabetes, 2010, 通讯作者
(38) Guo F, Cavener D. The GCN2 eIF2α Kinase Regulates Fatty-Acid Homeostasis in the Liver during Deprivation of an Essential Amino Acid, Cell Metabolism, 2007, 第 1 作者
(39) Zhang L, Guo F, Kim J, Saffen D. Muscarinic Acetylcholine Receptors Activate TRPC6 Channels in PC12D Cells via Ca2+ Store–Independent Mechanisms, J Biochem (Tokyo), 2006, 第 2 作者
(40) Ebihara T, Guo F, Zhang L, Kim JY, Saffen D. Muscarinic acetylcholine receptors stimulate Ca2+ influx in PC12D cells predominantly via activation of Ca2+ store-operated channels, J Biochem (Tokyo), 2006, 第 2 作者
(41) Guo F, Bakal K, Minokoshi Y, Hollenberg AN. Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo , Endocrinology, 2004, 第 1 作者
(42) Guo FF, Kumahara E, Saffen D. A CalDAG-GEFI/Rap1/B-Raf Cassette Couples M1 Muscarinic Acetylcholine Receptors to the Activation of ERK1/2, J Biol Chem, 2001, 第 1 作者

科研活动

   
科研项目
( 1 ) 创新经费, 负责人, 研究所自选, 2007-08--2009-12
( 2 ) 国家自然基金面上项目, 负责人, 国家任务, 2009-01--2011-12
( 3 ) 上海市浦江人才计划, 负责人, 地方任务, 2008-08--2010-08
( 4 ) 中国科学院“****”, 负责人, 中国科学院计划, 2009-01--2012-01
( 5 ) 中科院营养与代谢首席科学家项目, 参与, 中国科学院计划, 2009-01--2012-12
( 6 ) 973子课题, 参与, 国家任务, 2009-01--2013-08
( 7 ) 国家自然基金重大项目, 参与, 国家任务, 2009-01--2012-12
( 8 ) 973子课题, 参与, 国家任务, 2010-01--2014-12
( 9 ) 辉瑞(the CAS-Pfizer Project), 负责人, 国家任务, 2010-02--2012-02
( 10 ) 上海市“科技创新行动计划”基础研究重点科技项目, 负责人, 地方任务, 2010-10--2012-09
( 11 ) 上海市重大项目, 参与, 地方任务, 2008-10--2011-09
( 12 ) 营养科学研究所临床研究中心, 负责人, 国家任务, 2010-04--2012-04
( 13 ) 中枢神经系统感应氨基酸及调控脂质代谢的分子机制研究, 负责人, 国家任务, 2012-01--2016-12
( 14 ) ATF4调控脂肪细胞分化及糖脂代谢的作用及机制研究, 负责人, 国家任务, 2013-01--2016-12
( 15 ) 中枢神经系统感应氨基酸及其调控糖脂代谢的分子机制研究, 负责人, 地方任务, 2013-09--2016-08
( 16 ) 糖代谢稳态失衡的发生与发展(胰岛β细胞量、胰岛素信号转导调节机制与胰岛素抵抗), 参与, 国家任务, 2014-01--2018-12
( 17 ) 内分泌系统/代谢和营养支持, 负责人, 国家任务, 2014-01--2017-12
( 18 ) 中枢感应氨基酸并调控机体能量稳态的机制研究, 负责人, 国家任务, 2014-04--2017-03
( 19 ) 氨基酸感应蛋白通过改变肠道菌群维持机体代谢平衡稳态的作用, 负责人, 地方任务, 2016-07--2019-06
( 20 ) 营养对糖脂代谢和能量稳态的调控作用与机制研究, 负责人, 地方任务, 2017-05--2020-04
( 21 ) 营养与代谢创新交叉团队:代谢性疾病的发病机理与新靶标研究, 参与, 中国科学院计划, 2018-01--2020-12
( 22 ) 氨基酸调控机体能量和糖脂代谢的作用与机制, 负责人, 国家任务, 2019-01--2023-12
( 23 ) 中枢下丘脑c-Jun对机体能量和脂质代谢的调控作用与机制研究, 负责人, 国家任务, 2019-01--2022-12
参与会议
(1)分会主持   第三届中国生物物理学会代谢生物学分会学术研讨会   2019-05-10
(2)Central and peripheral mechanisms underlying glucocorticoid-increased adiposity   2018新加坡代谢性疾病学术研讨会   2018-11-12
(3)Central and Peripheral Mechanisms Underlying Glucocorticoid-Increased Adiposity   II型糖尿病的诱因,从基因到环境   2018-10-07
(4)Amino acid regulation of metabolism   新加坡国际肠-脑专题讨论会   2018-05-02
(5)氨基酸中枢感应机制   中英生命科学与医学高峰论坛   2017-09-26
(6)营养感应与健康   香山科学会议“营养健康科学前沿与产业服务”第602次学术讨论会   2017-08-28
(7)A role of amino acid in metabolism   2017年衰老与衰老相关疾病机制会议   2017-05-15
(8)Amino acids and metabolism   美国肝脏疾病研究协会第六十七届年会   2016-11-12
(9)Branched chain amino acids and metabolic signaling   2014-01-17
(10)Molecular mechanisms underlying amino acid regulation of metabolism    2013-04-26
(11)A role of hypothalamus in amino acid sensing and regulation of metabolism   亚太地区肥胖会议   2012-04-20
(12)Hypothalamic control of energy homeostasis during leucine deprivation   中日韩肥胖与糖尿病会议   2012-04-07
(13)Translational studies on glucose metabolism   糖尿病与代谢国际大会   2011-11-10
(14)none   2009-10-23