070303-有机化学

金属有机化学；不对称催化；有机合成

1980-09--上海有机化学研究所   博士

   

1980-09~现在, 上海有机化学研究所, 博士

   

（1） 国家自然科学奖, 二等奖, 国家级, 2013
（2） 上海市自然科学奖, 一等奖, 省级, 2012
（3） 中国化学会黄耀曾金属有机化学奖, , 其他, 2010
（4） 上海市领军人才, , 省级, 2007
（5） 礼来科研成就奖, , 其他, 2005
（6） 国家自然科学奖, 二等奖, 国家级, 2002
（7） 上海市科技进步奖, 一等奖, 省级, 2001
（8） 国家自然科学奖, 二等奖, 国家级, 1997

（ 1 ） 一种支链烯丙基化合物、制备方法及应用, 2015, 第 1 作者, 专利号: 201510570521.5

（ 2 ） 一种手性烯丙基胺类化合物、合成方法及其用途, 2010, 第 1 作者, 专利号: 201010619361.6

（ 3 ） 具有手性中心的苄位取代的恶唑啉膦配体、合成方法和应用, 2010, 第 1 作者, 专利号: ZL 200710037085.0

（ 4 ） 一种具有手性中心的恶唑啉环金属催化剂、合成及用途, 2008, 第 1 作者, 专利号: ZL 2004 1 0053911.7

   

（1） Palladium-Catalyzed Highly Diastereo- and Enantioselective [3+2] Cycloaddition of Vinyl Aziridines and α,β-Unsaturated Ketones, Angew. Chem. Int. Ed., 2015, 通讯作者
（2） Palladium-Catalyzed Asymmetric Intermolecular Mizoroki–Heck Reaction for Construction of a Chiral Quaternary Carbon Center, Chem. Commun., 2015, 通讯作者
（3） Kinetic Resolution of Unsymmetrical Acyclic Allyl Carbonates Using Trimethylsilyl Cyanide via Pd-Catalyzed Asymmetric Allylic Alkylation, Synlett, 2015, 通讯作者
（4） Pd-Catalyzed Allylic Alkylation of Dienyl Carbonates with Nitromethane in High C-5 Regioselectivity , Chem. Commun., 2014, 通讯作者
（5） A New Strategy to Construct C=C-CF3 Subunit via CuBr-Catalyzed Domino Reaction of Homopropargyl Amines: An Efficient Synthesis of Trifluoromethyl Containing Building Block 4-Trifluoromethyl-2,3-dihydro-pyrroliums, Chem. Commun., 2014, 通讯作者
（6） Pd-Catalyzed Highly Regio-, Diastereo-, and Enantioselective Allylic Alkylation of α-Fluorophosphonates, Chem. Commun., 2014, 通讯作者
（7） Kinetic Resolution of 2-Substituted-2,3-dihydro-4- pyridones by Palladium-Catalyzed Asymmetric Allylic Alkylation. Total Synthesis of Indolizidine (+)-209I, Org. Lett., 2014, 通讯作者
（8） Palladium-Catalyzed Regio-, Diastereo-, and Enantioselective Allylation of Nitroalkanes with Monosubstituted Allyl Substrates, J. Org. Chem., 2013, 通讯作者
（9） Switch of Addition and Ring-opening Reactions of Oxabicyclic Alkenes with Terminal Alkynes by sp2- and sp3-C,P-palladacycle Catalysis, Organometallics, 2013, 通讯作者
（10） Desymmetrization of Bicyclo[3,n,1]-3-one Derivatives by Palladium-Catalyzed Asymmetric Allylic Alkylation, Org. Lett., 2013, 通讯作者
（11） Enantioselective Synthesis of 2,3-Disubstituted Indanones via Pd-Catalyzed Intramolecular Asymmetric Allylic Alkylation of Ketones , Org. Lett., 2013, 通讯作者
（12） Regio- and Enantioselective Palladium-Catalyzed Allylic Alkylation of Nitromethane with Monosubstituted Allyl Substrates: Synthesis of (R)-Rolipram and (R)-Baclofen, J. Org. Chem. , 2012, 通讯作者
（13） Palladacycle-Catalyzed Reaction of Bicyclic Alkenes with Terminal Ynones: Regiospecific Synthesis of Polysubstituted Furans, Org.Lett, 2012, 通讯作者
（14） Chemo- and Regioselectivity-Tunable Pd-Catalyzed Allylic Alkylation of Imines, J. Am. Chem. Soc., 2011, 通讯作者
（15） Asymmetric Propargylation, Chem Rev, 2011, 通讯作者
（16） Clarification of a Misconception in the BINOL-Based Fluorescent Sensors: Synthesis and Study of Major-Groove BINOL-Amino Alcohols, Chem Commun, 2011, 通讯作者
（17） Diastereo- and Enantioselective Synthesis of alpha,gama-Diaminobutyric Acid Derivatives via Cu-Catalyzed Asymmetric Michael Reaction, Org Lett, 2010, 通讯作者
（18） Ag-Catalyzed Diastereo- and Enantio-selective Synthesis of β-Substituted Tryptophans from Sulfonylindole, Org Lett, 2010, 通讯作者
（19） Highly Enantioselective Fluorescent Recognition of Serine and Other Amino Acid Derivatives, Org Lett, 2010, 通讯作者
（20） Highly Enantioselective Iridium-Catalyzed Hydrogenation of Trisubstituted Olefins, α,β-Unsaturated Ketones and Imines with Chiral Benzylic Substituted P,N-Ligands, Adv Synth Catal, 2010, 通讯作者
（21） Palladium Catalyzed Regio-, Diastereo-, and Enantioselective Allylic Alkylation of Acylsilanes with Monosubstituted Allyl Substrates, J Am Chem Soc, 2010, 通讯作者
（22） Highly Enantioselective Recognition of Structurally Diverse alpha-Hydroxycarboxylic Acids by a Fluorescent Sensor, Angew Chem Int Ed, 2010, 通讯作者
（23） Highly Efficient Kinetic Resolution of 2-Substituted-2,3-Dihydro-4-Quinolones by Palladium-Catalyzed Asymmetric Allylic Alkylation, J Am Chem Soc, 2009, 通讯作者
（24） Asymmetric Copper-Catalyzed Propargylic Substitution Reaction of Propargylic Acetates with Enamines, Org Lett, 2009, 通讯作者
（25） Highly Diastereo- and Enantioselective Pd-Catalyzed Cyclopropanation of Acyclic Amides with Substituted Allyl Carbonates, J Am Chem Soc, 2009, 通讯作者
（26） Highly Enantioselective Cu-Catalyzed Conjugate Addition-Elimination of Activated Allylic Acetates with Glycine Derivatives, Org Lett, 2009, 通讯作者
（27） Highly Enantioselective construction of ？-Chiral Center of Amides via Iridium-Catalyzed Hydrogenation of α, β-Unsaturated Amides, Adv Synth Catal, 2009, 通讯作者
（28） Kinetic Resolution of Indolines by Pd-Catalyzed Asymmetric Allylic Amination, Org Lett, 2009, 通讯作者
（29） Enantioselective Precipitation and Fluorescent Enhancement in the Recognition of ？-Hydroxycarboxylic acids, Angew Chem Int Ed, 2009, 通讯作者
（30） A Dramatic Switch of Enantioselectivity in Asymmetric Heck Reaction by Benzylic Substituents of Ligands, J Am Chem Soc, 2008, 通讯作者
（31） Highly Enantioselective Palladium-Catalyzed alkylation of Acyclic Amides, Angew Chem Int Ed, 2008, 通讯作者
（32） Unexpected Transfer of Tosyl-Group of ArCH=NTs Catalyzed by N-Heterocyclic Carbene, J Org Chem, 2008, 通讯作者
（33） Iridium-Catalyzed Highly Enantioselective Hydrogenation of the C=C bond of α, β-Unsaturated Ketones, Angew Chem Int Ed, 2008, 通讯作者
（34） Highly Diastereoselectivity Switchable Enantioselective Mannich Reaction of Glycine Derivatives with Imines, J Am Chem Soc, 2008, 通讯作者

   

（ 1 ） 基于反应选择性控制的反应设计研究, 负责人, 国家任务, 2011-01--2014-12
（ 2 ） 通过钯催化烯丙基取代反应实现的动力学拆分, 负责人, 国家任务, 2009-01--2011-12
（ 3 ） 共价键选择性构建及相关规律研究（973子课题）, 负责人, 国家任务, 2011-01--2012-12
（ 4 ） 钯催化的"硬"碳亲核试剂的分子内不对称烯丙基烷基化反应, 负责人, 国家任务, 2013-01--2016-12
（ 5 ） 钯催化分子间不对称Heck反应及应用研究, 负责人, 国家任务, 2015-01--2018-12
（ 6 ） 基于亲核试剂对π-烯丙基过渡金属络合物反应选择性的反应方法学研究, 负责人, 国家任务, 2016-01--2020-12