Name : Pin NIE

Academic Title Professor

Education : Ph.D.

Phone 86-27-68780736


Address : No. 7 Donghu South Road, Wuchang District, Wuhan, Hubei Province

Research Areas

     Fish humoral immune system and immune responses, and pathogenicity of fish bacterial pathogen and possible vaccine development. Populations of schistosome and their intermediate host.

Personal Profile

   Born in 1961, with a Ph.D degree obtained in 1990 from the University of Exeter in the UK. Promoted to a full professor position in 1996 in the Institute of Hydrobiology, awarded in 2000 the Distinguished Young Scientists by the National Natural Science Foundation. Served as a deputy director from 1999 to 2007 in this institute.

   Academic career started from 1982 in the Sun Yat-sen (Zhongshan) University when conducting M.Sc study. Research experiences were obtained in the University of Exeter and the Keele University in the UK and also in the University of Tokyo in Japan. Collaborative research has been quite active and international, and joint research with domestic scientists has also been  an important issue in his laboratory. The collaborative research activities have been widely related with fish parasitology, schistosomes, fish diseases and fish immunology.

Work Experience

September,1996~Institute of Hydrobiology, Chinese Academy of Sciences, Professor.

28th December , 2001~30th December, 2016,The Committee of Fish Disease,China Society of Fisheries,Head of the Committee.




  1.   Gan, Z., Chen, S.N., Huang, B., Hou, J. & Nie, P. (acepted). Intronless and intron-containing type IFN genes coexist in amphibian Xenopus tropicalis: insights into the origin and evolution of type I IFNs in vertebrates. Developmental and Comparative Immunology.

  2.   Chen, S.N., Zhang, X.W., Li, L., Ruan, B.Y., Huang, B., Huang, W.S., Zou, P.F., Fu, J.P., Zhao, L.J., Li, N. & Nie, P. (2016). Type III IFNs in tetrapod vertebrates: conservation and variation in gene composition, and functional characterization in lizard reptiles. Developmental and Comparative Immunology 61: 208-224.

  3.   Gan, Z., Chen, S., Hou, J., Huo, H., Zhang, X., Ruan, B., Laghari, Z.A., Li, L., Lu, Y. & Nie, P., (2016). Molecular and functional characterization of peptidoglycanrecognition protein SC2 (PGRP-SC2) from Nile tilapia (Oreochromis niloticus) involved in the immune response to Streptococcus agalactiae. Fish and Shellfish Immunology 54: 1-10.

  4.   Lu, J.F., Wang, W.N., Wang, G.L., Zhang, H., Zhou, Y., Gao, Z.P., Nie, P. & Nie, P. (2016). Edwardsiella tarda EscE (Orf13 Protein) is a type III secretion system-secreted protein that is required for the injection of effectors, secretion of translocators, and pathogenesis in fish. Infection and Immunity 84: 2-10.

  5.   Lu, L.-F., Li, S., Lu, X.-B., LaPatra, S.E., Zhang, N., Zhang, X.-J., Chen, D.-D., Nie, P. & Zhang, Y.-A. (2016). Spring viremia of carp virus protein suppresses fish IFN f1 production by targeting the mitochondrial antiviral signaling protein. Journal of Immunology 196: 3744-3753.

  6.   Luo Z. Liu, Z. Fu, J., Zhang, Q., Huang, B. & Nie, P. (2016). Immunogenicity and protective role of antigenic regions from fi ve outer membrane proteins of Flavobacterium columnare in grass carp Ctenopharyngodon idella. Chinese Journal of Oceanology and Limnology 34: 1247-1257. 

  7.   Xu, Q., Jiang, Y., Wangkahart, E., Zou, J., Chang, M., Yang, D., Secombes, C.J., Nie, P. & Wang, T. (2016). Sequence and sxpression analysis of interferon regulatory factor 10 (IRF10) in three diverse teleost fish reveals tts role in antiviral defense. PLoS One 11: e0147181. doi:10.1371/journal.pone.0147181.

  8.   Yi, J., Xiao, S.B., Zeng, Z.X., Lu, J.F., Liu, L.Y., Laghari, Z.A., Nie, P., Yu, H.B., Xie, H.X. (2016). EseE of Edwardsiella tarda augments secretion of translocon protein EseC and expression of the escC-eseE Operon. Infection and Immunity 84: 2336-2344.

  9.   Zhang, Y., Nie, P., Lin, L. (2016). Complete genome sequence of the fish pathogen Flavobacterium columnare Pf1. Genome Announcements 4: e00900-16.

  10.  Zhang, L., Liu, Z., Fu, J., Zhang, Q., Huang, B., Nie, P. (2016). Immunogenicity and protective role of antigenic regions from five outer membrane proteins of Flavobacterium columnare in grass carp Ctenopharyngodon idella. Chinese Journal of Oceanology and Limnology 34: 1247-1257.

  11.   Zou, P.F., Chang, M.X., Li, Y., Xue, N.N., Li, J.H., Chen, S.N. & Nie, P. (2016). NOD2 in zebrafish funtions in a antibacterial and also antiviral responses via NF-kB, and also MDA5, RIG-1 and MAVS. Fish and Shellfish Immunology 55: 173-185.


  12.   Locke, S.A., Al-Nasiri, F.S., Caffara, M., Drago, F., Kalbe, M., Lapierre, A.L., McLaughlin, J.D., Nie, P., Overstreat, R.B., Souza, G.T.R., Takemoto, R.M. & Marcogliese, D.J. (2015). Diversity, specificity and speciation in larval Diplostomidae (Platyhelminthes: Digenea) in the eyes of freshwater fish, as revealed by DNA barcodes. International Journal for Parasitology 45: 841-855. Doi: 10.1016/j.ijpara.2015.07.001

  13.   Huang, B., Jia, Q.Q., Liang, Y., Huang, W.S. & Nie, P. (2015). Interferon regulatory factor 10 (IRF10): cloning in orange spotted grouper, Epinephelus coioides, and evolutionary analysis in vertebrates. Fish & Shellfish Immunology 46(2): 669-677.

  14.   Li, N., Qin, T., Zhang, X.L., Huang, B., Liu, Z.X., Xie, H.X., Zhang, J., McBride, M.J. & Nie, P. (2015). Development and use of a gene deletion strategy to examine the two chondroitin lyases in virulence of Flavobacterium columnare. Applied and Environmental Microbiology 81(21): 7349-7402. doi:10.1128/AEM.01586-15.

  15.   Gao, Z.P., Nie, P., Lu, J.F., Liu, L.Y., Xiao, T.Y., Liu, W., Liu, J.S. & Xie, H.X. (2015). Type III secretion system translocon component EseB forms filaments on and mediates autoaggrelation of and biofilm formation by Edwardsiella tarda. Applied and Environmental Microbiology 81 81:000–000. doi:10.1128/AEM.01254-15.

  16.   Chen, W.Q., Hu, Y.W., Zou, P.F., Ren, S.S., Nie, P. & Chang, M.X. (2015). MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. Developmental and Comparative Immunology 49: 19-30.

  17.   Qi, Z.T., Jiang, Y.S., Holland, J.W., Nie, P., Secombes, C.J. & Wang, T. (2015). Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynuchus mykiss). Fish and Shellfish Immunology 44: 389-398.

  18.   Xie, H.X., Lu, J.F., Zhou, Y., Yi, J., Yu, X.-J., Leung, K.Y. & Nie, P. (2015). Identifcation and functional characterization of the novel Edwardsiella tarda effector EseJ. Infection and Immunity 83: 1650-1660.

  19.   Zou, P.F., Chang, M.X., Li, Y., Zhang, S.H., Fu, J.P., Chen, S.N. & Nie, P. (2015). Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. Fish and Shellfish Immunology 43: 13-24.


  20.   Zou, P.F., Chang, M.X., Xue, N.N., Liu, X.Q., Li, J.H., Fu, J.P., Chen, S.N. &Nie, P. (2014). Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant. Immunology 141: 192-202.

  21.   Fu, J.P., Chen, S.N., Zou, P.F., Huang, B., Guo, Z., Zeng, L.B., Qin, Q.W. &Nie, P. (2014). IFN-γ in turtle: Conservation in sequence and signalling and role in inhibiting iridovirus replication in Chinese soft-shelled turtle Pelodiscus sinensis. Developmental and Comparative Immunology 43: 87-95.

  22.   Hu, Y.W., Yu, Z.L., Xue, N.N., Nie, P.& Chang, M.X. (2014). Expression and protective role of two novel NACHT-containing proteins in pathogen infection. Developmental and Comparative Immunology 46: 323-332.

  23.   Huang, B., Huang, W.S. &Nie, P. (2014). Cloning and expression analyses of interferon regulatory factor (IRF) 3 and 7 genes in European eel, Anguilla anguilla with the identification of genes involved in IFN production. Fish & Shellfish Immunology 37: 239-247.

  24.   Li, J.H., Yu, Z.L., Xue, N.N., Zou, P.F., Hu, J.Y., Nie, P.& Chang, M.X. (2014). Molecular cloning and functional characterization of peptidoglycan recognition protein 6 in grass carp Ctenopharyngodon idella. Developmental and Comparative Immunology 42: 244-255.

  25.   Li, S., Lu, L.F., Feng, H., Wu, N., Chen, D.D., Zhang, Y.B., Gui, J.F., Nie, P.& Zhang, Y.-A. (2014). IFN regulator factor 10 is a negative regulator of the IFN responses in fish. Journal of Immunology 193: 1100-1109.

  26.   Liu, Y., Whipps, C.M., Nie, P., Gu, Z. (2014). Myxobolus oralis sp. n. (Myxosporea: Bivalvulida) infecting the palate in the mouth of gibel carp Carassius auratus gibelio (Cypriniformes: Cyprinidae). Folia Parasitologica 61: 505-511.

  27.   Tian, J.Y., Qi, Z.T., Chang, M.X. & Nie, P. (2014). Complementary DNA sequences of the constant regions of T-cell antigen receptors α, β and g in mandarin fish, Siniperca chuatsi Basilewsky, and their transcriptional changes after stimulation with Flavobacterium columnare. Journal of Fish Diseases 37: 89-101.

  28.   Wang, X.H., Wang, K.R., Nie, P., Chen, X.H. & Ao, J.Q. (2014). Establishment and characterization of a head kidney cell line from large yellow croaker Pseudosciaena crocea. Journal of Fish Biology 84: 1551-1161.

  29.   Xie, H.X., Lu, J.F., Rolhion, N., Holden, D.W., Nie, P., Zhou, Y. & Yu, X.J. (2014). Edwardsiella tarda-induced cytotoxicity depends on its type III secretion system and flagellin. Infection and Immunity 82: 3436-3445.

  30.   Xu, Q.Q., Li, R.G., Monte, M.M., Jiang, Y.S., Nie, P., Holland, J.W., Secombes, C.J. & Wang, T. (2014). Sequence and expression analysis of rainbow trout CXCR2, CXCR3a and CXCR3b aids interpretation of lineage-specific conversion, loss and expansion of these receptors during vertebrate evolution. Developmental and Comparative Immunology 45: 201-213. 

  31.   Xu, Q.Q., Yang, D.Q., Tuo, R., Wan, J., Chang, M.X. & Nie, P. (2014) Gene cloning and induced expression pattern of IRF4 and IRF10 in the Asian swamp eel (Monopterus albus). Zoological Research 35: 380-388.

  32.   Yu, Z.L., Li. J.H, Xue, N.N., Nie, P. & Chang, M.X. (2014). Expression and functional characterization of PGRP6 splice variants in grass carp Ctenopharyngodon idella. Developmental and Comparative Immunology 47: 264-274.

  33.   Hu, X.J., Hu, X.P., Wen, C.G., Gao, Q., Xie, Y.H., Hu, B.Q., Wu, D., Tao, Z.Y., Li, A.H. (2014). Molecularcloning and characterization of cathepsin L from freshwater mussel, Cristaria plicata. Fish & Shellfish Immunology 40: 446-454.

  34.   Qi, Z.T., Chang, L.J., Zhang, Q.H., Wang, Z.S., Qiu, M., Huang, Y., Gao, Q. (2014). Molecular cloning, expression and in silico analysis of a long type peptidoglycan recognition protein from tongue sole, Cynoglossus semilaevis.Acta Ichthyologica et Piscatoria 44: 181-190.


  35.   Chang, M.X., Zou, J., Nie, P., Huang, B., Yu, Z.L., Collet, B. & Secombes, C.J. (2013). Intracellular interferons in fish: A unique means to combat viral infection. PLoS Pathogens 9: e1003736.

  36.   Chen, J., Xu, Q.Q., Wang, T., Collet, B., Corripio-Miyar, Y., Bird, S., Xie, P., Nie, P., Secombes, C.J. & Zou, J. (2013). Phylogenetic analysis of vertebrate CXC chemokines reveals novel lineage specific groups in teleost fish. Developmental and Comparative Immunology 41: 137-152.

  37.   Chen, S.N., Huang, B., Zhang, X.W., Li, Y., Zhao, L.J., Li, N., Gao, Q. &Nie, P. (2013). IFN-g and its receptors in a reptile reveal the evolutionary conservation of type II IFNs in vertebrates. Developmental and Comparative Immunology 41: 587-596.

  38.   Fu, J.P., Luo, Z., Yan, Y., Zou, P.F., Zhang, S.H., Qin, Q.W. &Nie, P. (2013). Establishment of a cell line from Chinese soft-shelled turtle Pelodiscus sinensis with the practicability of transfection and viral replication. Fish Pathology 48: 126-134. 

  39.   Guo, Z. & Nie, P. (2013). Sequencing and expression analysis of CD3γ/δ and CD3ε chains in mandarin fish, Siniperca chuatsi. Chinese Journal of Oceanology and Limnology 31: 106-117.

  40.   Guo, Z., Wang, G.L., Fu, J.P. &Nie, P. (2013). Characterization and expression of CD8 molecules in mandarin fish Siniperca chuatsi. Journal of Fish Biology 82, 189-205.

  41.   Huang, B., Huang, W.S. &Nie, P. (2013). Characterization of four Mx isoforms in the European eel, Anguilla anguilla. Fish & Shellfish Immunology 35: 1048-1054.

  42.   Li, J.H., Chang, M.X., Xue, N.N., Nie, P. (2013). Functional characterization of short peptidoglycan recognition protein, PGRP5 in grass carp Ctenopharyngodon idella. Fish & Shellfish Immunology 35: 221-230.

  43.   Pan, T.S. &Nie, P. (2013). The complete mitochondrial genome of Pallisentis celatus (Acanthocephala) with phylogenetic analysis of acanthocephalans and rotifers. Folia Parasitologica 60: 181-191.

  44.   Zhao, L.J., Lu, J.F., Nie, P., Li, A.H., Xiong, B.X. & Xie, H.X. (2013). Roles of plasmid-encoded proteins, EseH, EseI and EscD in invasion, replication and virulence of Edwardsiella ictaluri. Veterinary Microbiology 166: 233-241.


  45.   Li, N., Zhang, L.Q., Zhang, J., Liu, Z.X., Huang, B., Zhang, S.H. & Nie, P. (2012) Type I restriction-modification system and its resistance in electroporation efficiency in Flavobacterium columnare. Veterinary Microbiology160: 61-68.

  46.   Zhao, Q.P., Jiang, M.S., Dong. H.F. & Nie, P. (2012). Diversification of Schistosoma japonicum in Mainland China revealed by mitochondrial DNA. PLoS Neglected Tropical Diseases 6:e1503.

  47.   Zhang, S.H., Zhu, D.D., Chang, M.X., Zhao, Q.P., Jiao, R., Huang, B., Fu, J.P., Liu, Z.X. & Nie P. (2012). Three goose-type lysozymes in the gastropod Oncomelania hupensis: cDNA sequences and lytic activity of recombinant proteins. Developmental & Comparative Immunology 36:241-246.

  48.   Zhang, J., Zou, H., Wang, L.F., Huang, B., Li, N., Wang, G.T. & Nie, P. (2012). Construction of two selectable markers for integrative/conjugative plasmids in Flavobacterium columnare. Chinese Journalof Oceanology and Limnology 30:269-278.

  49.   Wang, H., Zhao, Q.P., Nie, P., Jiang, M.S. & Song, J.(2012). Identification of differentially expressed genes in Oncomelania hupensis chronically infected with Schistosoma japonicum. Experimental Parasitology 130:374-383.

  50.   Liu, Z.X,, Liu, G,Y., Li, N., Xiao, F.S., Xie, H.X. & Nie, P.(2012). Identification of immunogenic proteins of Flavobacterium columnare by two-dimensional electrophoresis immunoblotting with antibacterial sera from grass carp, Ctenopharyngodon idella (Valenciennes). Journal of Fish Diseases, 35: 255-263.

  51.   Wang, G., Li J., Zou, P., Xie, H., Huang, B., Nie, P. & Chang, M. (2012). Expression pattern, promoter activity and bactericidal property of β-defensin from the mandarin fish Siniperca chuatsi. Fish &Shellfish Immunology 33: 522-531.


  52.   Chang, M.X., Collet, B., Nie, P., Lester, K., Campbell, S. & Secombes, C.J., Zou, J. (2011). Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in Rainbow trout (Oncorhynchus mykiss).Journal of Virology 85:8403-8412.

  53.   Chang, M.X., Wang, T., Nie, P., Zou, J. & Secombes, C.J. (2011). Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains. Fish &Shellfish Immunology 30:118-127.

  54.   Guo, H.Z., Zou, P.F., Fu, J.P., Guo, Z., Zhu, B.K., Nie, P. & Chang, M.X.(2011). Characterization of two C-type lectin-like domain (CTLD)-containing proteins from the cDNA library of Chinese mitten crab Eriocheir sinensis. Fish &Shellfish Immunology 30:515-524.

  55.   Li, W.X., Song, R., Wu, S.G., Zou, H., Nie, P. & Wang, G.T. (2011). Seasonal occurrence of helminths in the anadromous fish Coilia nasus (Engraulidae): parasite indicators of fish migratory movements. Journal ofParasitology 97:192-196.

  56.   Wei, Y.C., Pan, T.S., Chang, M.X., Huang, B., Xu, Z., Luo, T.R. & Nie, P. (2011). Cloning and expression of Toll-like receptors 1 and 2 from a teleost fish, the orange-spotted grouper Epinephelus coioides. Veterinary Immunology & Immunopathology 141: 173-182.

  57.   Yan, W., Nie, P. & Lu, Y. (2011). Establishment, characterization and viral susceptibility of a new cell line derived from goldfish, Carassius auratus (L.), tail fin. Journal of Fish Diseases 34:757-768.


  58.   Chang, M.X., Chen, W.Q. & Nie, P. (2010). Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappaB signalling. Developmental & Comparative Immunology 34:1-13.

  59.   Chen, D., Guo, X. & Nie, P. (2010). Phylogenetic studies of sinipercid fish (Perciformes: Sinipercidae) based on multiple genes, with first application of an immune-related gene, the virus-induced protein (viperin) gene. Molecular Phylogenettics & Evolution 55:1167-1176.

  60.   Chen, W.Q., Xu, Q.Q., Chang, M.X., Nie, P. & Peng, K.M. (2010). Molecular characterization and expression analysis of nuclear oligomerization domain proteins NOD1 and NOD2 in grass carp Ctenopharyngodon idella. Fish &Shellfish Immunology 28:18-29.

  61.   Chen, W.Q., Xu, Q.Q., Chang, M.X., Zou, J., Secombes, C.J., Peng, K.M. & Nie, P. (2010). Molecular characterization and expression analysis of the IFN-gamma related gene (IFN-gammarel) in grass carp Ctenopharyngodon idella. Veterinary Immunology & Immunopathology 134:199-207.

  62.   Huang, B., Qi, Z.T., Xu, Z. & Nie, P. (2010). Global characterization of interferon regulatory factor (IRF) genes in vertebrates: glimpse of the diversification in evolution. BMC Immunology 11:22.

  63.   Li, N., Zhang, J., Zhang, L.Q. & Nie, P. (2010). Difference in genes between a high virulence strain G4 and a low virulence strain G18 of Flavobacterium columnare by using suppression subtractive hybridization. Journal of Fish Diseases 33: 403-412.

  64.   Li, W.X., Wang, G.T., Yao, W.J. & Nie, P. (2010). Frequency distribution and seasonal dynamics of intestinal helminths in the yellowhead catfish Pelteobagrus fulvidraco from Liangzi Lake, China. Comparative Parasitology 77:31-36.

  65.   Qi, Z., Nie, P., Secombes, C.J. & Zou, J. (2010). Intron-containing type I and type III IFN coexist in amphibians: refuting the concept that a retroposition event gave rise to type I IFNs. Journal of Immunology 184:5038-5046.

  66.   Tan, X.L., Shi, X.L., Liu, G.J., Xu, H.L. & Nie, P. (2010). An approach to analyzing taxonomic patterns of protozoan communities for monitoring water quality in Songhua River, northeast China. Hydrobiologia 638: 193-201.

  67.   Wang, T., Gao, Q., Nie, P. & Secombes, C.J. (2010). Identification of suppressor of cytokine signalling (SOCS) 6, 7, 9 and CISH in rainbow trout Oncorhynchus mykiss and analysis of their expression in relation to other known trout SOCS. Fish &Shellfish Immunology 29:656-667.

  68.   Xiao, F.S., Wang, Y.P., Yan, W., Chang, M.X., Yao, W.J., Xu, Q.Q., Wang, X.X., Gao, Q. & Nie, P. (2010). Ig heavy chain genes and their locus in grass carp Ctenopharyngodon idella. Fish &Shellfish Immunology 29:594-599.

  69.   Xie, H.X., Yu, H.B., Zheng, J., Nie, P., Foster, L.J., Mok, Y.K., Finlay, B.B. & Leung, K.Y. (2010). EseG, an effector of the type III secretion system of Edwardsiella tarda, triggers microtubule destabilization. Infection & Immunity 78:5011-5021.

  70.   Xu, Q.Q., Chang, M.X., Xiao, F.S., Huang, B. & Nie, P. (2010). The gene and virus-induced expression of IRF-5 in grass carp Ctenopharyngodon idella. Veterinary Immunology & Immunopathology 134:269-278.

  71.   Zhang, S.H., Zhao, Q.P., Jiao, R., Gao, Q. & Nie, P. (2010). Identification of polymorphic microsatellites for the intermediate host Oncomelania hupensis of Schistosoma japonicum in China. Malacologia 53:147-153.

  72.   Zhao, Q.P., Jiang, M.S., Littlewood, D.T. & Nie, P. (2010). Distinct genetic diversity of Oncomelania hupensis, intermediate host of Schistosoma japonicum in mainland China as revealed by ITS sequences. PLoS Neglected Tropical Diseases 4:e611. 

  73.   Zhao, Q.P., Zhang, S.H., Deng, Z.R., Jiang, M.S. & Nie, P. (2010). Conservation and variation in mitochondrial genomes of gastropods Oncomelania hupensis and Tricula hortensis, intermediate host snails of Schistosoma in China. Molecular Phylogenettics & Evolution 57:215-226.


  74.   Chang, M.X., Nie, P., Collet, B., Secombes, C.J. & Zou, J. (2009). Identification of an additional two-cysteine containing type I interferon in rainbow trout Oncorhynchus mykiss provides evidence of a major gene duplication event within this gene family in teleosts. Immunogenetics 61:315-325.

  75.   Chang, M.X., Wang, Y.P. & Nie, P. (2009). Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways. Fish &Shellfish Immunology 26:264-274.

  76.   Gao, D., Wang, G.T., Chen, X.T. & Nie, P. (2009). Metallothionein-2 gene from the mandarin fish Siniperca chuatsi: cDNA cloning, tissue expression, and immunohistochemical localization. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology149:18-25.

  77.   Gao, Q., Nie, P., Thompson, K.D, Adams, A., Wang, T., Secombes, C.J. & Zou, J. (2009). The search for the IFN-gamma receptor in fish: Functional and expression analysis of putative binding and signalling chains in rainbow trout Oncorhynchus mykiss. Developmental & Comparative Immunology 33:920-931.

  78.   Li, W.X., Nie, P., Wang, G.T. & Yao, W.J. (2009). Communities of gastrointestinal helminths of fish in historically connected habitats: habitat fragmentation effect in a carnivorous catfish Pelteobagrus fulvidraco from seven lakes in flood plain of the Yangtze River, China. Parasites &Vectors2: 22.

  79.   Li, Y., Sun, B.J., Wu, H.J. & Nie, P. (2009). Effects of pure microcystin-LR on the transcription of immune related genes and heat shock proteins in larval stage of zebrafish (Danio rerio). Aquaculture289:154-160.

  80.   Liu, Y., Chang, M.X., Wu, S.G. & Nie, P. (2009). Characterization of C-C chemokine receptor subfamily in teleost fish. Molecular Immunology 46:498-504.

  81.   Tian, J.Y., Sun, B., Luo, Y., Zhang, Y. & Nie, P. (2009). Distribution of IgM, IgD and IgZ in mandarin fish, Siniperca chuatsi lymphoid tissues and their transcriptional changes after Flavobacterium columnare stimulation. Aquaculture 288:14-21.

  82.   Tian, J.Y., Xie, H.X., Zhang, Y.A., Xu, Z., Yao, W.J. & Nie, P. (2009). Ontogeny of IgM-producing cells in the mandarin fish Siniperca chuatsi identified by in situ hybridisation. Veterinary Immunology & Immunopathology 132:146-152.

  83.   Wei, L.L., Sun, B.J., Chang, M.X., Liu, Y. & Nie, P. (2009). Effects of cyanobacterial toxin microcystin-LR on the transcription levels of immune-related genes in grass carp Ctenopharyngodon idella. Environmental Biology of Fishes 85:231-238.

  84.   Wu, S.G., Wang, G.T., Xi, B.W., Xiong, F., Liu, T. & Nie, P. (2009). Population genetic structure of the parasitic nematode Camallanus cotti inferred from DNA sequences of ITS1 rDNA and the mitochondrial COI gene. Veterinary Parasitology 164:248-256.

  85.   Xi, B.W., Wang, G.T., Wu, S.G. & Nie, P. (2009). New record of genus Atractolytocestus in China with redescription of A. sagittatus (Cestoda, Caryophyllidea) from Cyprinus carpio. Acta Zootaxonomica Sinica 34: 407-410.

  86.   Xiong, F., Wang, G.T., Wu, S.G. & Nie, P. (2009). Development of Eustrongylides ignotus (Nematoda: Dioctophmida) in domestic ducks (Anas platyrhynchos domestica (L.). Journal of Parasitology 95: 1035-1039.

  87.   Xu, Z., Wang, G.L. & Nie, P. (2009). IgM, IgD and IgY and their expression pattern in the Chinese soft-shelled turtle Pelodiscus sinensis. Molecular Immunology 46, 2124-2132.

  88.   Xu, Z., Chang, M.X., Qi, Z.T., Huang, B. & Nie, P. (2009).Immunoglobulin joining (J) chain and its expression in the Chinese soft-shelled turtle (Pelodiscus sinensis). Veterinary Immunology & Immunopathology 131:268-272.

  89.   Zou, J., Chang, M., Nie, P. & Secombes, C.J. ( 2009). Origin and evolution of the RIG-I like RNA helicase gene family.BMC Evolutionary Biology 9:85.


  90.   Chang, M.X. & Nie, P. (2008). RNAi suppression of zebrafish peptidoglycan recognition protein 6 (zfPGRP6) mediated differentially expressed genes involved in Toll-like receptor signaling pathway and caused increased susceptibility to Flavobacterium columnare. Veterinary Immunology & Immunopathology 124:295-301.

  91.   Gao, D., Wang, G.T., Xi, B.W., Yao, W.J. & Nie, P. (2008). A new species of Allocreadium (Trematoda: Allocreadiidae) from freshwater fishes in the Danjiangkou Reservoir in China. Journal of Parasitology 94:176-180.

  92.   Gao, Y., Chang, M.X., Sun, B.J. & Nie, P.(2008). TRAIL in the mandarin fish Siniperca chuatsi: gene and its apoptotic effect in HeLa cells. Fish &Shellfish Immunology 24:55-66.

  93.   Li, W.X., Wang, G.T. & Nie, P. (2008).Genetic variation of fish parasite populations in historically connected habitats: undetected habitat fragmentation effect on populations of the nematode Procamallanus fulvidraconis in the catfish Pelteobagrus fulvidraco. Journal of Parasitology 94:643-647.

  94.   Liu, G.Y., Nie, P., Zhang, J. & Li, N. (2008). Proteomic analysis of the sarcosine-insoluble outer membrane fraction of Flavobacterium columnare. Journal of Fish Diseases 31:269-276.

  95.   Moravec, F., Nie, P. & Wang, G.T. (2008). Redescription and systematic status of Neocapilaria phoxini Yu et Wang, 1994 (Nematoda: Capillariidae). Folia Parasitologica 55: 316-318.

  96.   Qi, Z.T. & Nie, P. (2008). Comparative study and expression analysis of the interferon gamma gene locus cytokines in Xenopus tropicalis. Immunogenetics 60:699-710.

  97.   Song ,Y., Wang, G.T., Yao, W.J., Gao, Q. & Nie, P. (2008).Phylogeny of freshwater parasitic copepods in the Ergasilidae (Copepoda: Poecilostomatoida) based on 18S and 28S rDNA sequences. Parasitology Research 102:299-306.

  98.   Wei, L.L., Sun, B.J. & Nie, P. (2008). Ultrastructural alteration of lymphocytes in spleen and pronephros of grass carp (Ctenopharyngodon idella) experimentally exposed to microcystin-LR. Aquaculture 280:270-275.

  99.   Wei, L.L., Sun, B.J., Song, L.R. & Nie,P. (2008). Gene expression profiles in liver of zebrafish treated with microcystin-LR. Environmental Toxicology and Pharmacology 26:6-12.

  100. Wu, S.G., Wang, G.T., Xi, B.W., Gao, D. & Nie, P. (2008). Molecular characteristics of Camallanus spp. (Spirurida: Camallanidae) in fishes from China based on its rDNA sequences. Journal of Parasitology 94:731-736.

  101. Xu, Z.Y., Nie, P., Chang, M.X. & Sun, B.J. (2008). Cloning, characterization and expression analysis of SIMP (source of immunodominant MHC-associated peptides) in grass carp Ctenopharyngodon idella. Fish &Shellfish Immunology 24:701-714.


  102. Chang, M.X., Nie, P. & Wei, L.L. (2007). Short and long peptidoglycan recognition proteins (PGRPs) in zebrafish, with findings of multiple PGRP homologs in teleost fish. Molecular Immunology 44:3005-3023.

  103. Chang, M.X. & Nie, P. (2007). Intelectin gene from the grass carp Ctenopharyngodon idella: cDNA cloning, tissue expression, and immunohistochemical localization. Fish &Shellfish Immunology 23:128-140.

  104. Chang, M.X., Sun, B.J. & Nie, P. (2007). The first non-mammalian CXCR3 in a teleost fish: gene and expression in blood cells and central nervous system in the grass carp (Ctenopharyngodon idella). Molecular Immunology 44:1123-1134.

  105. Chen, D.L., Guo, X.G. & Nie, P. (2007). Non-monophyly of fish in the Sinipercidae (Perciformes) as inferred from cytochrome b gene. Hydrobiologia583:77-89.

  106. Chen, D.L., Wang, G.T., Yao, W.J. & Nie, P. (2007). Utility of ITS1-5.8S-ITS2 sequences for species discrimination and phylogenetic inference of two closely related bucephalid digeneans (Digenea: Bucephalidae): Dollfustrema vaneyi and Dollfustrema hefeiensisParasitology Research 101:791-800.

  107. Gao, Q., Chen, M.X., Yao, W.J., Gao, Y., Song, Y., Wang, G.T., Wang, M.X. & Nie, P. (2007).Phylogeny of diplozoids in five genera of the subfamily diplozoinae palombi, 1949 as inferred from ITS-2 rDNA sequences. Parasitology134:695-703.

  108. Harun, N.O., Zou, J., Zhang, Y.A., Nie, P. & Secombes, C.J. (2007). The biological effects of rainbow trout (Oncorhynchus mykiss) recombinant interleukin-8. Developmental & Comparative Immunology 32:673-681.

  109. Li, L., Chang, M.X. & Nie, P. (2007). Molecular cloning, promoter analysis and induced expression of the complement component C9 gene in the grass carp Ctenopharyngodon idella. Veterinary Immunology & Immunopathology 118:270-282.

  110. Sun, B.J., Chang, M.X., Song, Y., Yao, W.J. & Nie, P. (2007). Gene structure and transcription of IRF-1 and IRF-7 in the mandarin fish Siniperca chuatsi. Veterinary Immunology & Immunopathology 116:26-36.

  111. Sun, B.J., Xie, H.X., Song, Y. & Nie, P. (2007). Gene structure of an antimicrobial peptide from mandarin fish, Siniperca chuatsi (Basilewsky), suggests that moronecidins and pleurocidins belong in one family: the piscidins. Journal of Fish Diseases 30:335-343.

  112. Wu, S.G., Wang, G.T., Xi, B.W., Gao, D. &Nie, P. (2007). Population dynamics and maturation cycle of Camallanus cotti (Nematoda: Camallanidae) in the Chinese hooksnout carp Opsariichthys bidens (Osteichthyes: Cyprinidae) from a reservoir in China. Veterinary Parasitology 147, 125-131.


1Diversification of Schistosoma japonicum and Oncomelania hupensis in China.   Nie. P,  29th March , 2014.

2Invasion of green fluorescent protein-tagged Flavobacterium columnare in embryos of zebrafish (Danio rerio) and identification of protective antigens of F. columnare.   Zhang Xiaolin,Qin Ting, Liu zhixin, Li Nan , Nie. P, 5th June , 2012.



谢海侠  博士研究生  071004-水生生物学  

高原  博士研究生  071004-水生生物学  

孙军  博士研究生  071004-水生生物学  

宋英  博士研究生  071004-水生生物学  

罗海燕  博士研究生  071004-水生生物学  

文春根  博士研究生  071004-水生生物学  

徐在言  博士研究生  071004-水生生物学  

高谦  博士研究生  071004-水生生物学  

孙宝剑  博士研究生  071004-水生生物学  

朱宁宁  博士研究生  071004-水生生物学  

昌鸣先  博士研究生  071004-水生生物学  

刘国勇  博士研究生  071004-水生生物学  

陈达丽  博士研究生  071004-水生生物学  

鲁义善  博士研究生  071004-水生生物学  

李文祥  博士研究生  071004-水生生物学  

刘毅  博士研究生  071004-水生生物学  

王欣欣  硕士研究生  071004-水生生物学  

田敬云  博士研究生  071004-水生生物学  

李楠  博士研究生  071004-水生生物学  

骆彦萍  博士研究生  071004-水生生物学  

张晶  硕士研究生  071004-水生生物学  

张金  博士研究生  071004-水生生物学  

齐志涛  博士研究生  071004-水生生物学  

肖凡书  博士研究生  071004-水生生物学  

王改玲  博士研究生  071004-水生生物学  

张立强  博士研究生  071004-水生生物学  

朱丹丹  硕士研究生  071004-水生生物学  

刘涛  硕士研究生  071004-水生生物学  

郭政  博士研究生  071004-水生生物学  

李军华  博士研究生  071004-水生生物学  

杨五名  博士研究生  071004-水生生物学  

黄贝  博士研究生  071004-水生生物学  

张书环  博士研究生  071004-水生生物学  

刘志新  博士研究生  071004-水生生物学  

严伟  博士研究生  071004-水生生物学  

刘金玉  博士研究生  071004-水生生物学  

付建平  博士研究生  071004-水生生物学  

焦冉  博士研究生  071004-水生生物学  

邹鹏飞  博士研究生  071004-水生生物学  

李烨  硕士研究生  071004-水生生物学  

卢金芳  博士研究生  071004-水生生物学  

陈善楠  博士研究生  071004-水生生物学  

张晓林  博士研究生  071004-水生生物学  

秦婷  博士研究生  071004-水生生物学  

阮柏野  硕士研究生  071004-水生生物学  

李丽  博士研究生  071004-水生生物学  

霍慧君  博士研究生  071004-水生生物学  

侯静  博士研究生  071004-水生生物学  

甘桢  博士研究生  071004-水生生物学  

卢小兵  博士研究生  071004-水生生物学  

赵文婷  博士研究生  071004-水生生物学  


金庸  博士研究生  071004-水生生物学  

黄琳  博士研究生  071004-水生生物学  

王凯伦  博士研究生  071004-水生生物学  

杨月丛  博士研究生  071004-水生生物学  

杨柳  博士研究生  071004-水生生物学  

邓雨杭  硕士研究生  071004-水生生物学  

廖晓坚  博士研究生  071004-水生生物学  

牛萌萌  博士研究生  071004-水生生物学  

季家祥  硕士研究生  086000-生物与医药  

Honors & Distinctions

Ranked fourth of the 2nd Grade Prize of the Advanced Scientific and Technological Award of the Country in 2006, and also ranked fourth of the 1st Grade Prize of the Advanced Scientific and Technological Award of Shandong Province in 2005.