基本信息
邵华武  男  博导  中国科学院成都生物研究所
电子邮件: shaohw@cib.ac.cn
通信地址: 四川省成都市人民南路四段九号
邮政编码: 610041

招生信息

   
招生专业
100701-药物化学
070303-有机化学
招生方向
抗肿瘤活性化合物的设计、合成及活性研究
药物化学和有机化学中化学合成、转化、修饰
抗糖尿病活性的糖类化合物的设计、合成及活性研究

教授课程

糖化学

专利与奖励

   
专利成果
( 1 ) 一种盐酸罗匹尼罗的制备方法, 2018, 第 1 作者, 专利号: 201810431530.X

( 2 ) 3-取代氧化吲哚类衍生物的制备方法, 2018, 第 1 作者, 专利号: 201810079937.0

( 3 ) 一种新奥霉素的全合成方法, 2017, 第 1 作者, 专利号: 201711180837.9

( 4 ) N-烷基多羟基哌啶衍生物的制备方法, 2013, 第 1 作者, 专利号: ZL201010275412.8

( 5 ) 一种胺及其衍生物的磺酰化方法, 2013, 第 1 作者, 专利号: ZL200910058638.X

( 6 ) 一种糖原酸酯的制备方法, 2013, 第 1 作者, 专利号: ZL200810147709.9

( 7 ) 一种有机叠氮化合物的制备方法, 2013, 第 1 作者, 专利号: ZL200910059516.2

( 8 ) 一种2-脱氧-?-D-吡喃葡萄糖基三唑类化合物的制备方法, 2011, 第 1 作者, 专利号: 201110166751.7

( 9 ) 一种立体选择性制备吡喃衍生物的方法, 2011, 第 1 作者, 专利号: 201110061982.1

( 10 ) 一种6-O-磺酰基-烯糖类化合物的制备方法, 2011, 第 1 作者, 专利号: ZL2008100453294

( 11 ) 一种制备阿拉伯烯糖的方法, 2011, 第 1 作者, 专利号: ZL2007100488640

( 12 ) 一种立体选择性制备吡喃衍生物的方法, 2011, 第 1 作者, 专利号: 201110061982.1

( 13 ) 2-C-乙酰甲基-2-脱氧-D-吡喃葡萄糖的制备方法, 专利号: 200610022637.6

( 14 ) 一种葡萄烯糖的制备方法, 专利号: 200710048471.x

( 15 ) 2-脱氧-D-吡喃葡萄糖的制备方法, 专利号: 200610022637.6

( 16 ) 一种木糖烯糖的制备方法, 专利号: 200710049337.1

( 17 ) N-取代-1-脱氧野尻霉素类化合物及其制备方法, 专利号: 200810045328.X

( 18 ) 一种制备3,4-二-O-乙酰基-L-鼠李烯糖的方法, 专利号: 200810045330.7

( 19 ) 2-C-乙酰甲基-2-脱氧-葡萄糖苷类化合物的制备方法, 专利号: 200810044483.x

( 20 ) 一种烯糖的制备方法, 专利号: 200810147708.4

( 21 ) 一种糖原酸酯的制备方法, 专利号: 200810147709.9

( 22 ) 一种胺及其衍生物的磺酰化方法, 专利号: 200910058638.X

( 23 ) 一种有机叠氮化合物的制备方法, 专利号: 200910059516.2

( 24 ) 一种制备阿拉伯烯糖的方法, 专利号: 200710048864.0

( 25 ) 一种吡喃葡萄糖衍生物及其制备方法, 专利号: 200710048863.6

( 26 ) 一种糖原酸酯的制备方法 , 专利号: 200810045480.8

出版信息

   
发表论文
(1) Synthesis of N-alkyl substituted iminosugars from D-ribose, Chin. Chem. Lett., 2018, 通讯作者
(2) D-alanyl-D-alanine- Modified Gold Nanoparticles Form a Broad-Spectrum Sensor for Bacteria, Theranostics, 2018, 通讯作者
(3) A Facile Method for the Synthesis of Fused Perhydropyrano[2,3-b]pyrans Promoted by Yb(OTf)3, CHEMICAL COMMUNICATIONS, 2018, 通讯作者
(4) Oxadiazepine Synthesis by Formal [4+3] Cycloaddition of o-Chloromethyl Arylsulfonamides with Nitrones Promoted by NaHCO3, Advanced Synthesis & Catalysis, 2018, 通讯作者
(5) Organic nanostructure-based probes for two-photon imaging of mitochondria and microbes with emission between 430 nm and 640 nm, NANOSCALE, 2017, 通讯作者
(6) Pharmaceutical Intermediate-Modified Gold Nanoparticles: Against Multidrug-Resistant Bacteria and Wound-Healing Application via an Electrospun Scaffold, ACS NANO, 2017, 通讯作者
(7) An efficient method for the stereoselective synthesis of N-substituted trihydroxypiperidine derivatives promoted by p-TsOH, Tetrahedron, 2016, 通讯作者
(8) Lathyrol Diterpenes as Modulators of P-Glycoprotein Dependent Multidrug Resistance: Structure-Activity Relationship Studies on Euphorbia Factor L-3 Derivatives, J. Med. Chem., 2015, 通讯作者
(9) Zn(OTf) promoted rearrangement of 1,2-cyclopropanated sugars with amines: a convenient method for the synthesis of 3-polyhydroxyalkyl-substituted pyrrole derivatives, Organic & Biomolecular Chemistry, 2015, 通讯作者
(10) Stereospecific [3+2] Cycloaddition of 1,2-Cyclopropanated Sugars and Ketones Catalyzed by SnCl4: an Efficient Synthesis of Multi-Substituted Perhydrofuro[2,3-b]furans and Perhydrofuro[2,3-b]pyrans, Chemical Communications, 2014, 通讯作者
(11) Synthesis of the 6,6,5,7-Tetracyclic Core of Daphnilongeranin B, Chemical Communications, 2014, 通讯作者
(12) Methanesulfonic-Acid-Catalysed Ring Opening and Glycosylation of 1,2-(Acetylcyclopropane)-Annulated D-Lyxofuranose, Eur. J. Org. Chem. , 2014, 通讯作者
(13) A Neighboring Group Participation Strategy: Direct and Highly Diastereoselective Synthesis of 2-Substituted and 2,2-Bisubstituted Perhydrofuro[2,3-b]pyran Derivatives, Org. Biomol. Chem., 2014, 通讯作者
(14)  An Efficient and Simple Method for Stereoselective Synthesis of N-Substituted Iminosugars from D-Xylose Derivative, Chin. J. Chem., 2014, 通讯作者
(15)  Label-Free Colorimetric Detection of Cadmium Ions in Rice Samples Using Gold, Anal. Chem., 2014, 第 3 作者
(16) Hydrothermal synthesis of highly fluorescent carbon nanoparticles from sodium citrate and their use for the detection of mercury ions, CARBON, 2013, 通讯作者
(17) Convenient synthesis of sulfonyl azides using PEG-400 as an efficient and eco-friendly reaction medium, Green Chemistry Letters and Reviews, 2013, 通讯作者
(18) A convenient and highly stereoselective method for synthesis of octahydropyrano[3,2-b]pyrrole derivatives, Carbohydrate Research, 2013, 通讯作者
(19) Analysis of lathyrane diterpenes using electrospray ionization quadrupole time-of-flight mass spectrometry, Rapid Communications in Mass Spectrometry, 2013, 通讯作者
(20) Rhopeptin A, first cyclopeptide isolated from Rhodobryum giganteum, Helvetica Chimica Acta, 2013, 通讯作者
(21) A new hepatotoxic triterpenoid ketone from Curculigo orchioides, Fitoterapia, 2013, 通讯作者
(22) 太子参红外指纹图谱的双指标序列分析, 天然产物研究与开发, 2013, 第 3 作者
(23) Rapid synthesis of glycosyl bromides by ultrasound irradiation, Chemical Research in Chinese Universities, 2013, 通讯作者
(24) Straightforward and highly diastereoselective synthesis of 2,2-di-substituted perhydrofuro[2,3-b]-pyran (and furan) derivatives promoted by BiCl3, Chemical Communications, 2013, 通讯作者
(25) Synthesis, characterisation and magnetic behaviour of ionic metalloporphyrins: metal–tetrakis(N-octyl-4-pyridinium)–porphyrins with tetrabromoferrate (III) anions, Journal of Chemical Research, 2013, 通讯作者
(26) InCl3 Catalyzed Highly Diastereoselective [3+2] Cycloaddition of 1,2-Cyclopropanated Sugars with Aldehydes: A Straightforward Synthesis of Persubstituted Bis-Tetrahydrofurans and Perhydrofuro[2,3-b]pyrans, Organic Letters, 2013, 通讯作者
(27) Synthesis of Novel 4,6-Anhydro-α-D-Galactopyranose Derivatives, Chinese Journal of Synthetic Chemistry, 2013, 通讯作者
(28) Synthesis of Novel 2-C-acetonyl Glucopyranosyl Triazole Compounds, Chinese Journal of Synthetic Chemistry, 2013, 通讯作者
(29) Simple and Efficient Method for N-Boc Protection of Amines Using PEG-400 as a Reaction Medium Under Mild Conditions, Synthetic Communications, 2012, 通讯作者
(30) Stable fluorescent gold nanoparticles for detection of Cu2+ with good sensitivity and selectivity, Analyst, 2012, 通讯作者
(31) A practical high-throughput screening system for feruloyl esterases: substrate design and evaluation, J. Mol. Catal. B: Enzym., 2012, 通讯作者
(32) Investigations on a series of novel ionic liquids containing the [closo-B12Cl12]2- dianion, RSC Advances, 2012, 通讯作者
(33) Synthesis of 3-O-Acetyl-4,6-Di-O-Benzyl-1,2- Cyclopropaneacetylated Glucose, Chinese Journal of Synthetic Chemistry, 2012, 通讯作者
(34) Stereoselective Synthesis of 2-C-Branched (Acetylmethyl)Oligosaccharides and Glyco- conjugates: Lewis Acid-Catalyzed Glycosylation from 1,2-Cyclopropane- acetylated Sugars, J. Org. Chem., 2011, 通讯作者
(35) A Novel and Highly Stereoselective Synthesis of 2-Substituted Perhydrofuro[2,3-b]pyran Derivatives, Organic Letters, 2011, 通讯作者
(36) An efficient synthesis of 3-substituted indole derivates under ultrasound irradiation, Ultrasonics Sonochemistry, 2011, 通讯作者
(37) Colorimetric detection of mercury, lead and copper ions simultaneously using protein-functionalized gold nanoparticles, Biosensors and Bioelectronics, 2011, 通讯作者
(38) Stereoselective Synthesis of a Series of New N-Alkyl-3-hydroxypiperidine Derivatives Containing a Hemiketal, Eur. J. Org. Chem., 2011, 通讯作者
(39) PEG 400 promoted nucleophilic substitution reaction of halides into organic azides under mild conditions , Green Chemistry Letters and Reviews, 2011, 通讯作者
(40) Stereoselective Synthesis of 2-C-Acetonyl-2-Deoxy-D-Galactosides using 1,2-Cyclopropaneacetylated Sugar as Novel Glycosyl Donor , Organic Letters , 2010, 通讯作者
(41) A simple and convenient method for the synthesis of pyranoid glycals , Carbohydrate Research, 2010, 通讯作者
(42) Synthesis of N-substituted iminosugars from 2′-carbonyl-C-glycofuranosides , Carbohydrate Research, 2009, 通讯作者
(43) Bismuth(III) chloride-catalyzed one-pot Mannich reaction: three-component synthesis of β-amino carbonyl compounds, Tetrahedron Letters, 2009, 通讯作者
(44) A facile method for the preparation of sugar orthoesters promoted by anhydrous sodium bicarbonate, Canadian Journal of Chemistry, 2009, 通讯作者
(45) Using Azobenzene-Embedded Self-Assembled Monolayers To Photochemically Control Cell Adhesion Reversibly, Angewandte Chemie International Edition, 2009, 通讯作者
(46) A mild and environmentally benign method for the synthesis of glycals in PEG-600/H2O, Green Chem., 2009, 通讯作者
(47) One-pot three-component Mannich-type reactions using Sulfamic acid catalyst under ultrasound irradiation , Ultrasonics - Sonochemistry, 2009, 通讯作者

科研活动

   
科研项目
( 1 ) 多羟基氮杂环类化合物的合成新方法研究, 负责人, 国家任务, 2010-01--2012-12
( 2 ) 中药质量系统评价方法、体系及技术标准平台, 参与, 国家任务, 2009-01--2010-12
( 3 ) 传统中药千金子中Lathyrane型抗肿瘤多药耐药二萜成分的研究, 参与, 国家任务, 2011-01--2013-12
( 4 ) 抗肿瘤活性的糖类化合物的设计、合成及活性研究, 负责人, 国家任务, 2009-01--2011-12
( 5 ) 治疗II型糖尿病创新药物的研究, 参与, 其他国际合作项目, 2013-01--2014-12
( 6 ) 新型氮杂糖类化合物的设计、合成及生物活性研究, 负责人, 国家任务, 2014-01--2017-12
( 7 ) 新型微生物源抗逆制剂与杀虫剂的研制及应用, 负责人, 中国科学院计划, 2016-01--2018-12
( 8 ) 活性天然化合物发现、评价与转化, 负责人, 中国科学院计划, 2016-11--2018-06
( 9 ) 天然广谱抗菌化合物GS-J及衍生物的合成和生物活性研究, 负责人, 国家任务, 2018-01--2021-12