基本信息
宋建国  男  博导  中国科学院分子细胞科学卓越创新中心
电子邮件: jgsong@sibcb.ac.cn
通信地址: 江安路99弄梅花园1号
邮政编码:

招生信息

   
招生专业
071010-生物化学与分子生物学
招生方向
细胞可塑性与细胞命运决定及肿瘤生长转移

教育背景

1987-09--1993-04   纽约州立大学   生物化学博士
1979-09--1982-08   北京医学院   医学硕士

工作经历

   
工作简历
1996-01~现在, 中国科学院上海生命科学学院生物化学与细胞生物学研究所, 研究员
1993-04~1995-12,加利福尼亚大学旧金山分校, 博士后
1987-09~1993-04,纽约州立大学, 生物化学博士
1982-09~1987-12,北京癌症研究所, 助理研究员
1979-09~1982-08,北京医学院, 医学硕士

出版信息

   
发表论文
(1) TUFM downregulation induces epithelial-mesenchymal transition and invasion in lung cancer cells via a mechanism involving AMPK-GSK3β signaling., Cell Mol Life Sci., 2016, 通讯作者
(2) Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis., Nature Communication., 2015, 通讯作者
(3) Hepatocyte nuclear factor 6 suppresses the migration and invasive growth of lung cancer cells through p53 and the inhibition of epithelial-mesenchymal transition., J Biol Chem., 2013, 通讯作者
(4) TMEPAI regulates EMT in lung cancer cells by modulating the ROS and IRS-1 signaling pathways., Carcinogenesis, 2013, 通讯作者
(5) Zac1 is a histone acetylation-regulated NF-κB suppressor that mediates histone deacetylase inhibitor-induced apoptosis., Cell Death and Differentiation, 2011, 通讯作者
(6) FOXA2 functions as a suppressor for tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers., Cell Res., 2011, 通讯作者
(7) Glucocorticoid induces mesenchymal-to-epithelial transition and inhibits TGF-β1-induced epithelial-mesenchymal transition and cell migration., FEBS Lett., 2010, 通讯作者
(8) AMP-activated protein kinase is required for induction of apoptosis and epithelial-to-mesenchymal transition., Cell Signal., 2010, 通讯作者
(9) Histone deacetylase 1 and 2 differentially regulate apoptosis via opposing effects on extracellular signal-regulated kinase 1/2., Cell Death and Disease, 2010, 通讯作者
(10) Histone deacetylase 1 is required for transforming growth factor-β1-induced epithelial-mesenchymal transition., Int J Biochem Cell Biol, 2010, 通讯作者
(11) Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor γ (PPARγ)., Biology of the Cell, 2010, 通讯作者
(12) Comparative proteomic analysis of cell cycle-dependent apoptosis induced by transforming growth factor-beta., Biochim Biophys Acta, 2009, 通讯作者
(13) Nitric oxide suppresses transforming growth factor-β1-induced epithelial-to-mesenchymal transition and apoptosis in mouse hepatocytes., Hepatology, 2009, 通讯作者
(14) Insulin receptor substrate-1 suppresses transforming growth factor-beta1-mediated epithelial–mesenchymal transition., Cancer Res., 2009, 通讯作者
(15) Ferritin heavy chain-mediated iron homeostasis and subsequent increased reactive oxygen species production are essential for epithelial-mesenchymal transition., Cancer Res., 2009, 通讯作者
(16) Protein kinase A suppresses the differentiation of 3T3-L1 preadipocytes., Cell Res., 2008, 通讯作者
(17) Regulation of Transforming Growth Factor-B1–Induced Apoptosis and Epithelial-to-Mesenchymal Transition by Protein Kinase and Signal Transducers and Activators of Transcription 3., Cancer Res., 2006, 通讯作者
(18) Transforming growth factor-β1 induces epithelial-to-mesenchymal transition and apoptosis via a cell cycle-dependent mechanism., Oncogene, 2006, 通讯作者
(19) Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation., Int. J. Biochem. Cell Biol., 2006, 通讯作者

科研活动

   
科研项目
( 1 ) TUFM调控EMT及肺癌浸润转移的作用及其机理研究, 负责人, 国家任务, 2014-12--2018-12
( 2 ) 前折叠蛋白在肺癌生长转移中的作用及其机理, 负责人, 国家任务, 2017-01--2020-12