基本信息
钟大放  男  博导  中国科学院上海药物研究所
电子邮件: dfzhong@mail.shcnc.ac.cn
通信地址: 上海市浦东新区海科路501号
邮政编码:

招生信息

   
招生专业
100704-药物分析学
招生方向
药物代谢
色谱质谱分析

教育背景

1986-09--1989-12   德国波恩大学   研究生,博士学位
1982-02--1984-12   沈阳药学院   研究生,硕士学位
1978-03--1982-01   沈阳药学院   大学本科,学士学位

工作经历

   
工作简历
2005-03~现在, 中国科学院上海药物研究所, 研究员
1994-07~2005-03,沈阳药科大学, 教授
1990-01~1994-06,德国药师中心实验室, 博士后
1986-09~1989-12,德国波恩大学, 研究生,博士学位
1985-01~1986-09,沈阳药学院, 助教
1982-02~1984-12,沈阳药学院, 研究生,硕士学位
1978-03~1982-01,沈阳药学院, 大学本科,学士学位
社会兼职
1997-01-01-2008-05-31,国务院学位委员会, 学科评议组成员
1996-05-01-今,国家药典委员会, 委员

专利与奖励

   
奖励信息
(1) 化学创新药物代谢和药动学研究, 二等奖, 部委级, 2015
(2) 108种制剂的药物动力学和生物等效性研究, 二等奖, 省级, 2003

出版信息

   
发表论文
(1) Characterization of TPN729 metabolites in humans usingultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry., Journal of Pharmaceutical and Biomedical Analysis, 2016, 通讯作者
(2) Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers., Drug Design, Development and Therapy, 2016, 通讯作者
(3) Derivatization methods for LC–MS analysis of endogenous compounds., Bioanalysis, 2015, 通讯作者
(4) Human liver cytochrome P450 enzymes and microsomal thiol methyltransferase are involved in the stereoselective formation and methylation of the pharmacologically active metabolite of clopidogrel., Drug Metabolism and Disposition, 2015, 通讯作者
(5) Potential role of organic anion transporting polypeptide 1B1 in the selective hepatic uptake of hematoporphyrin monomethyl ethyl ether isomers., Acta Pharmacologica Sinica, 2015, 通讯作者
(6) Simultaneous determination of ornidazole and its main metabolites in human plasma by LC-MS/MS: application to a pharmacokineric study., Bioanalysis, 2014, 通讯作者
(7) Metabolism and pharmacokinetics of allitinib in cancer patients: the roles of cytochrom P450s and epoxide hydrolase in its biotransformation., Drug Metabolism and Disposition, 2014, 通讯作者
(8) Development of a UHPLC-MS/MS method for the determination of plasma histamine in various mammalian species., Journal of Chromatography B, 2014, 通讯作者
(9) Metabolism and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor apatinib in humans., Drug Metabolism and Disposition, 2013, 通讯作者
(10) Stereoselective glucuronidation of ornidazole in humans: predominant contribution of UDP-glucuronosyltransferases 1A9 and 2B7., Drug Metabolism and Disposition, 2013, 通讯作者
(11) Metabolite profiling and identification of triptolide in rats., Journal of Chromatography B, 2013, 通讯作者
(12) Characterization of metabolites of GLS4 in humans using ultrahigh-performance liquid chromatography/quadrupole time-of-flight mass spectrometry., Rapid Communications in Mass Spectrometry, 2013, 通讯作者
(13) 用于液相色谱串联质谱定量生物分析的衍生化方法, Derivatization methods for quantitative bioanalysis by liquid chromatography-tandem mass spectrometry., Bioanalysis, 2012, 通讯作者
(14) Mechanistic studies on the absorption and disposition of scutellarin in humans: Selective OATP2B1-mediated hepatic uptake plays a major role in its unique pharmacokinetic characteristics., Drug Metabolism and Disposition, 2012, 通讯作者
(15) In vitro studies on the oxidative metabolism of 20(S)-ginsenoside Rh2 in human, monkey, dog, rat and mouse liver microsomes, and human liver S9., Drug Metabolism and Disposition, 2012, 通讯作者
发表著作
( 1 ) 类药性质:概念、结构设计与方法,从ADME到安全性优化, Drug-like Properties: Concepts, Structure Design and Methods, 科学出版社, 2011-01, 第 1 作者
Handbook of Metabolic Pathways of Xenobiotics, Wiley, 2014-01, 第 5 作者

科研活动

   
科研项目
( 1 ) 雷腾舒代谢产物合成及衍生物类药性质研究, 负责人, 国家任务, 2014-01--2017-12
( 2 ) 基于纳米技术的抗癌药物新型递释系统-代谢与药动学研究, 负责人, 国家任务, 2016-01--2021-12
( 3 ) 张江国家自主创新示范区精准抗肿瘤治疗创新服务平台-临床药动学研究, 负责人, 地方任务, 2015-01--2016-12