基本信息

范祖森,二级研究员,创新课题组组长,国科大微免教研室副主任,中国科学院特聘核心骨干研究员,国科大岗位教授(A类)。范祖森1998年获上海交通大学医学院免疫学博士学位,随后到哈佛大学医学院从事博士后研究,于2003年晋升为哈佛大学讲师。2004年作为中国科学院****研究员回到生物物理所工作,2005年获杰出青年基金资助,2006年入选新世纪百千万人才工程国家级人才。2010年享受国务院特殊津贴专家。2014年获得谈家桢生命科学创新奖,20162018年评为中科院优秀研究生导师等,2018年获得北京市科技进步一等奖,2019年基金委创新群体首席科学家,2020年国家重点研发专项首席科学家。课题组长期从事天然免疫抗感染/抗肿瘤应答调控、肿瘤干细胞和肿瘤免疫治疗等研究,在天然免疫细胞新亚群发现、天然免疫抗感染识别机制、肿瘤干细胞自我更新机制等方面,取得了一系列有重要国际影响力的原创性成果。Cell2篇)Nat Immunol6篇)Immunity3篇)Cell Stem Cell2篇)、Nat Cell BiolJEM5篇)JCINSMBNat Commun9篇) EMBO J4篇)Blood等国际权威学术期刊发表SCI高水平研究论文80余篇,研究处于国际前沿。课题组经过多年的研究积累业已形成一流的免疫生物学研究平台和优秀的科研文化氛围,在天然免疫抗感染应答与肿瘤免疫领域培养出一支优秀的科研团队。已培养了30余位博士毕业生和10余位博士后,10余人获得中科院院长特别奖、优秀奖及优秀博士论文,10余人晋升为教授岗位(包括中科院、北大、清华、复旦等教授),10余人获得中组部****、基金委优青等。


研究领域

1、         天然免疫新亚群发现与抗感染/抗肿瘤机制

2、         非编码RNA与免疫调控

3、         肿瘤干细胞与肿瘤免疫


招生信息

   
招生专业
071010-生物化学与分子生物学
100102-免疫学
招生方向
肿瘤免疫
肿瘤干细胞
免疫细胞发育

专利与奖励

   
奖励信息
(1) 2009年度北京市自然科学奖,三等奖,省级,2010
专利成果
(1) 人膀胱癌肿瘤标志物及其抗体和应用,发明,2010,第2作者,专利号:201010251384.6

出版信息

   
发表论文
(1) The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells., EMBO J., 2020, 通讯作者
(2) An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution., Nat Commun, 2020, 通讯作者
(3) Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer., Cell Res., 2020, 通讯作者
(4) Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis, J Exp Med., 2020, 通讯作者
(5) The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling., J Hepatol., 2019, 通讯作者
(6) LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling, EMBO J, 2019, 通讯作者
(7) Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis, J Exp Med, 2019, 通讯作者
(8) Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription, J Exp Med, 2019, 通讯作者
(9) IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3, Nature Immunology, 2019, 通讯作者
(10) The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity., Nat Immunol., 2018, 通讯作者
(11) Circular RNA cia-cGAS protects dormant hematopoietic stem cells from DNA sensor cGAS-mediated exhaustion., Immunity, 2018, 通讯作者
(12) Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice., Nat Commun., 2018, 通讯作者
(13) LncKdm2b controls self-renewal of embryonic stem cells via activation of transcription factor Zbtb3., EMBO J., 2018, 通讯作者
(14) LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis., Nat Cell Biology, 2018, 通讯作者
(15) Long noncoding RNA lncHand2 promotes liver repopulation via c-Met signaling., J Hepatol, 2018, 通讯作者
(16) The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling., J Hepatol, 2018, 通讯作者
(17) Cancer stem cells and tumorigenesis, Biophys Rep, 2018, 通讯作者
(18) Long noncoding RNA lncAIS downregulation in mesenchymal stem cells is implicated in the pathogenesis of adolescent idiopathic scoliosis., Cell Death Diferentiation, 2018, 通讯作者
(19) natural-killer-like B cell function as a separate subset of innate B cell, Immunity, 2017, 通讯作者
(20) IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development., Nat Commun., 2017, 通讯作者
(21) Single-cell Sequencing Reveals Variants in ARID1A, GPRC5A and MLL2 Driving Self-renewal of Human Bladder Cancer Stem Cells., Eur Urol., 2017, 第 1 作者
(22) Mesenchymal stem cells promote hepatocarcinogenesis via lncRNA-MUF interaction with ANXA2 and miR-34a., Cancer Res., 2017, 通讯作者
(23) Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2, Nat Commun., 2017, 通讯作者
(24) Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation., Cell., 2017, 通讯作者
(25) Long noncoding RNA lncKdm2b is required for ILC3maintenance by initiation of Zfp292 expression, Nature Immunology, 2017, 通讯作者
(26) WASH is required for the maintenance of NKp46+ ILC3 cells through promoting AHR expression, Nature Communications, 2017, 通讯作者
(27) Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity., Nat Immunol, 2016, 通讯作者
(28) GALNT1-mediated glycosylation and activation of sonic hedgehog signaling maintains the self-renewal and tumor-initiating capacity of bladder cancer stem cells., Cancer Res, 2016, 通讯作者
(29) Natural killer-like B cells prime innate lymphocytes against microbial infection, Immunity, 2016, 通讯作者
(30) lnc-β-Catm elicits EZH2-dependent β-cateninstabilization and sustains liver CSC self-renewal, Nat Struct Mol Biol, 2016, 通讯作者
(31) LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells., Nat Commun., 2016, 通讯作者
(32) WASH has a critical role in NK cell cytotoxicity through Lck-mediated phosphorylation., Cell Death Dis., 2016, 通讯作者
(33) Novel variants in MLL confer to bladder cancer recurrence identified by whole-exome sequencing., Oncotarget., 2016, 通讯作者
(34) DNA sensor cGAS-mediated immune recognition., Protein Cell., 2016, 通讯作者
(35) Structural insights into the regulatory mechanism of the Pseudomonas aeruginosa YfiBNR system., Protein Cell., 2016, 通讯作者
(36) FoxO1-mediated autophagy is required for NK cell development and innate immunity, Nature Communications, 2016, 通讯作者
(37) WASH has a critical role in NK cell Q1 cytotoxicity through Lck-mediated phosphorylation, Cell Death Dis, 2016, 通讯作者
(38) ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells., J Clin Invest, 2015, 通讯作者
(39) C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling., Nat Commun, 2015, 通讯作者
(40) IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation., Nat Commun, 2015, 通讯作者
(41) Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages., J Exp Med, 2015, 通讯作者
(42) Autophagy and cell reprogramming., Cell Mol Life Sci, 2015, 通讯作者
(43) The C228T mutation of TERT promoter frequently occurs in bladder cancer stem cells and contributes to tumorigenesis of bladder cancer., Oncotarget, 2015, 通讯作者
(44) The Endoplasmic Reticulum Adaptor Protein ERAdP Initiates NK Cell Activation via the Ubc13-Mediated NF-κB Pathway., J Immunol., 2015, 通讯作者
(45) The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling., Cell Stem Cell., 2015, 通讯作者
(46) Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection., Nat Immunol., 2015, 通讯作者
(47) Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability., Stem Cells, 2014, 通讯作者
(48) Molecular mechanism for self-protection against type VI secretion system in Vibriocholerae., Acta Crystallographica Section D, 2014, 通讯作者
(49) T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand Engagement Suppresses Interferon- Production of natural killer cells via -arrestin 2-mediated Negative Signaling., J. Biol. Chem., 2014, 通讯作者
(50) BCMab1, a monoclonal antibody against aberrantly glycosylated Integrin31, has potent antitumor activity of bladder cancer in vivo., Clin Can Res., 2014, 通讯作者
(51) RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy., Cell Res., 2014, 通讯作者
(52) WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner., J Exp Med., 2014, 通讯作者
(53) Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis through modulating Mad2 polyglutamylation., J Exp Med., 2014, 通讯作者
(54) Identification of SERPINB1 As a Physiological Inhibitor of Human Granzyme H., J. Immunol., 2013, 通讯作者
(55) Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells., Cell Death Differ., 2013, 通讯作者
(56) WASH inhibits autophagy through suppression of Beclin 1 ubiquitination., EMBO J., 2013, 通讯作者
(57) Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency, Cell Stem Cell, 2013, 通讯作者
(58) Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif, J. Immunol., 2012, 通讯作者
(59) Granzyme H of cytotoxic lymphocytes is required for clearance of the hepatitis B virus through cleavage of the hepatitis B virus X protein., J. Immunol., 2012, 通讯作者
(60) Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin alpha1/beta dimer of infected host cells., Cell Death Differ., 2012, 通讯作者
(61) FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade., Cell Death Differ., 2012, 通讯作者
(62)  VCP cleavage by granzyme K disrupts endoplasmic reticulum associated protein degradation to force tumor target cell death., Journal of Immunology, 2010, 通讯作者
(63)  Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells., J Biol Chem., 2010, 通讯作者
(64) Granzyme F induces a novel death pathway characterized by Bid-independent cytochrome c release without caspase activation. , Cell Death and Differentiation., 2009, 通讯作者
(65) Ignition of p53 bomb by granzyme K sensitizes tumor cells to NK cell-mediated cytolysis. , Journal of Immunology., 2009, 通讯作者
(66)  Structural Basis for Proteolytic Specificity of the Human Apoptosis-Inducing Granzyme M. , Journal of Immunology. , 2009, 通讯作者
(67) Granulysin induces cathepsin B release of lysosomes of target tumor cells to target mitochondria through processing of Bid. , Journal of Immunology, 2009, 通讯作者
发表著作
(1) 免疫学前沿进展(第2版),免疫学前沿进展(第2版),人民卫生出版社,2011-07,第2作者
(2) 免疫学前沿进展(第1版),免疫学前沿进展(第1版),人民卫生出版社,2009-11,第2作者

科研活动

   
科研项目
(1) 免疫应答效应相关蛋白质的生物学功能及其作用机制研究,主持,部委级,2010-01--2014-12
(2) SET蛋白复合体的结构与功能研究,主持,国家级,2009-01--2012-12

指导学生

已指导学生

侯强  博士研究生  071010-生物化学与分子生物学  

吕红霞  博士研究生  071010-生物化学与分子生物学  

华国强  博士研究生  071010-生物化学与分子生物学  

郭玉明  博士研究生  071010-生物化学与分子生物学  

张红莲  博士研究生  071010-生物化学与分子生物学  

胡德庆  博士研究生  071009-细胞生物学  

刘侃  硕士研究生  071010-生物化学与分子生物学  

吴连锋  博士研究生  071010-生物化学与分子生物学  

石磊  博士研究生  071010-生物化学与分子生物学  

现指导学生

安云鹤  博士研究生  071009-细胞生物学  

王丽  博士研究生  071010-生物化学与分子生物学  

唐海东  博士研究生  071010-生物化学与分子生物学  

王硕  博士研究生  071010-生物化学与分子生物学  

钟超  博士研究生  071010-生物化学与分子生物学  

杨轩  博士研究生  071010-生物化学与分子生物学  

刘圣武  博士研究生  071010-生物化学与分子生物学  

陈俊  博士研究生  071010-生物化学与分子生物学  

郝璐  硕士研究生  071010-生物化学与分子生物学  

杨昭  硕士研究生  071010-生物化学与分子生物学  

李倩  博士研究生  071010-生物化学与分子生物学  

夏朋延  博士研究生  071010-生物化学与分子生物学  

刘本宇  硕士研究生  071010-生物化学与分子生物学  

黄贯岭  硕士研究生  071010-生物化学与分子生物学  

李曼  博士研究生  071010-生物化学与分子生物学  

丁志超  博士研究生  071010-生物化学与分子生物学