071007-遗传学

基因组学
行为遗传学

1988-06--1992-12 美国德克萨斯州A&M大学化学系 博士学习
1978-09--1982-07 北京大学 本科学习

   

2010-09--今 中国科学院北京生命科学研究院 研究员
2005-09--2010-08 中国科学院心理研究所 研究员
1999-09--2005-08 美国康奈尔大学威尔医学院特护医学实验室 助理教授
1998-09--1999-08 路易斯安那州立大学神经科学中心 助理教授
1994-07--1998-08 贝勒医学院分子人类遗传学系 博士后
1993-01--1994-06 德克萨斯州大学安德生癌症研究中心 博士后

表观基因组学研究进展、 博导论坛(行为遗传学)

   

[1] 梁加龙, 张坤, 滕花景, 孙中生. 一种具有单碱基分辨率的检测DNA甲基化和单核苷酸变异的测序文库及应用. CN: CN108949945B, 2021-02-26.

[2] 藤花景, 陈云, 梁加龙, 孙中生. 一种全转录组范围单碱基分辨率检测RNA内部N7-甲基鸟苷修饰的方法及试剂盒. CN: CN108841934A, 2018-11-20.

[3] 梁加龙, 滕花景, 李津臣, 孙中生. 一种甲状腺癌致病相关的基因融合变异检测试剂盒. CN: CN106591431A, 2017-04-26.

[4] 滕花景, 梁加龙, 李津臣, 孙中生. 一种自闭症致病基因、易感基因和可能相关基因变异检测试剂盒. CN: CN106591430A, 2017-04-26.

   

[1] Wang, Yan, Zhang, Kaifan, Guo, Jin, Yang, Shuyan, Shi, Xiaohui, Pan, Jinrong, Sun, Zheng, Zou, Jizhen, Li, Yi, Li, Yuanyuan, Fan, Tianda, Song, Wei, Cheng, Fang, Zeng, Cheng, Li, Jinchen, Zhang, Ting, Sun, Zhong Sheng. Loss-of-Function of p21-Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects. ADVANCED SCIENCE[J]. 2023, 10(4): http://dx.doi.org/10.1002/advs.202204018.
[2] Song, Wei, Li, Quan, Wang, Tao, Li, Yuanyuan, Fan, Tianda, Zhang, Jianghong, Wang, Qingqing, Pan, Jinrong, Dong, Qiwen, Sun, Zhong Sheng, Wang, Yan. Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders. BRAIN BEHAVIOR AND IMMUNITY[J]. 2022, 102: 237-250, http://dx.doi.org/10.1016/j.bbi.2022.02.027.
[3] Wang, Tao, Zhao, Tingting, Liu, Liqiu, Teng, Huajing, Fan, Tianda, Li, Yi, Wang, Yan, Li, Jinchen, Xia, Kun, Sun, Zhongsheng. Integrative analysis prioritised oxytocin-related biomarkers associated with the aetiology of autism spectrum disorder. EBIOMEDICINE[J]. 2022, 81: https://doaj.org/article/a44ee8d537764e0ea0c69047209dc6b0.
[4] Miao, Zhuang, Li, Yuanyuan, Mao, Fengbiao, Zhang, Jianghong, Sun, Zhong Sheng, Wang, Yan. Prenatal witness stress induces intergenerational anxiety-like behaviors and altered gene expression profiles in male mice. NEUROPHARMACOLOGY[J]. 2022, 202: http://dx.doi.org/10.1016/j.neuropharm.2021.108857.
[5] Shi, Xiaohui, Teng, Huajing, Shi, Leisheng, Bi, Wenjian, Wei, Wenqing, Mao, Fengbiao, Sun, Zhongsheng. Comprehensive evaluation of computational methods for predicting cancer driver genes. BRIEFINGS IN BIOINFORMATICS[J]. 2022, 23(2): http://dx.doi.org/10.1093/bib/bbab548.
[6] Wang, Lu, Li, Jinchen, Wang, Chan, Tang, Ruqi, Liang, Jialong, Gong, Yuhua, Dai, Yaping, Ding, Ningling, Wu, Jian, Dai, Na, Liu, Lei, Zhao, Yi, Shao, Youlin, Zhao, Weifeng, Jiang, Peng, Shi, Xingjuan, Chen, Weichang, Tian, Ye, Liu, Xiangdong, Ma, Xiong, Sun, Zhongsheng. Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism. JOURNAL OF GENETICS AND GENOMICS[J]. 2022, 49(2): 145-154, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000763195300006.
[7] Shi, Xiaohui, Teng, Huajing, Sun, Zhongsheng. An updated overview of experimental and computational approaches to identify non-canonical DNA/RNA structures with emphasis on G-quadruplexes and R-loops. BRIEFINGS IN BIOINFORMATICSnull. 2022, 23(6): http://dx.doi.org/10.1093/bib/bbac441.
[8] Yuanyuan Li, Tianda Fan, Xianfeng Li, Liqiu Liu, Fengbiao Mao, Yi Li, Zhuang Miao, Cheng Zeng, Wei Song, Jinrong Pan, Shutang Zhou, Mary E Sunday, Hongbing Wang, Yan Wang, Zhong Sheng Sun. Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors. CELL REPORTS[J]. 2022, 41(6): http://dx.doi.org/10.1016/j.celrep.2022.111551.
[9] Kaifan Zhang, Yan Wang, Tianda Fan, Cheng Zeng, Zhong Sheng Sun. The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders. PROTEIN & CELL[J]. 2022, 13(1): 6-25, [10] Li, Yi, Zang, Yue, Fan, Tianda, Li, Zhaochen, Li, Anzi, Lv, Wei, Wang, Qingqing, Li, Qinglan, Li, Yuanyuan, Li, Quan, Sun, Zhongsheng, Teng, Huajing. Transcriptomic signatures associated with autoimmune thyroiditis in papillary thyroid carcinoma and cancer immunotherapy-induced thyroid dysfunction. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL[J]. 2022, 20: 2391-2401, http://dx.doi.org/10.1016/j.csbj.2022.05.019.
[11] Ran, Xia, Xiao, Jinyuan, Cheng, Fang, Wang, Tao, Teng, Huajing, Sun, Zhongsheng. Pan-cancer analyses of synonymous mutations based on tissue-specific codon optimality. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL[J]. 2022, 20: 3567-3580, https://doaj.org/article/23f02b88b5004a5185dfcf25b6b675f9.
[12] Zhang, Chunbo, Zhong, Tianyu, Li, Yuanyuan, Li, Xianfeng, Yuan, Xiaopeng, Liu, Linlin, Wu, Weilin, Wu, Jing, Wu, Ye, Liang, Rui, Xie, Xinhua, Kang, Chuanchuan, Liu, Yuwen, Lai, Zhonghong, Xiao, Jianbo, Tang, Zhixian, Jin, Riqun, Wang, Yan, Xiao, Yongwei, Zhang, Jin, Li, Jian, Liu, Qian, Sun, Zhongsheng, Zhong, Jianing. The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis. ELIFE[J]. 2021, 10: http://dx.doi.org/10.7554/eLife.70672.sa2.
[13] Mei, Yue, Teng, Huajing, Li, Zhigang, Zeng, Cheng, Li, Yuanyuan, Song, Wei, Zhang, Kaifan, Sun, Zhong Sheng, Wang, Yan. Restricted Feeding Resets Endogenous Circadian Rhythm in Female Mice Under Constant Darkness. NEUROSCIENCE BULLETIN[J]. 2021, 37(7): 1005-1009, http://dx.doi.org/10.1007/s12264-021-00669-w.
[14] Zhang, Yi, Wang, Tao, Wang, Yan, Xia, Kun, Li, Jinchen, Sun, Zhongsheng. Targeted sequencing and integrative analysis to prioritize candidate genes in neurodevelopmental disorders. MOLECULAR NEUROBIOLOGY[J]. 2021, 58(8): 3863-3873, http://dx.doi.org/10.1007/s12035-021-02377-y.
[15] Tao Wang, Yi Zhang, Liqui Liu, Yan Wang, Huiqian Chen, Tianda Fan, Jinchen Li, Kun Xia, Zhongsheng Sun. Targeted sequencing and integrative analysis of 3,195 Chinese patients with neurodevelopmental disorders prioritized 26 novel candidate genes. JOURNAL OF GENETICS AND GENOMICS[J]. 2021, 48(4): 312-323, [16] Wang, Tao, Ruan, Shasha, Zhao, Xiaolu, Shi, Xiaohui, Teng, Huajing, Zhong, Jianing, You, Mingcong, Xia, Kun, Sun, Zhongsheng, Mao, Fengbiao. OncoVar: an integrated database and analysis platform for oncogenic driver variants in cancers. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(D1): D1289-D1301, http://dx.doi.org/10.1093/nar/gkaa1033.
[17] Jialong Liang, Kun Zhang, Jie Yang, Xianfeng Li, Qinglan Li, Yan Wang, Wanshi Cai, Huajing Teng, Zhongsheng Sun. A new approach to decode DNA methylome and genomic variants simultaneously from double strand bisulfite sequencing. BRIEFINGS IN BIOINFORMATICS[J]. 2021, 22(6): [18] Ran, Xia, Xiao, Jinyuan, Zhang, Yi, Teng, Huajing, Cheng, Fang, Chen, Huiqian, Zhang, Kaifan, Sun, Zhongsheng. Low intratumor heterogeneity correlates with increased response to PD-1 blockade in renal cell carcinoma. THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY[J]. 2020, 12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758866/.
[19] Teng, Huajing, Xue, Meiying, Liang, Jialong, Wang, Xingxing, Wang, Lu, Wei, Wenqing, Li, Chao, Zhang, Ze, Li, Qinglan, Ran, Xia, Shi, Xiaohui, Cai, Wanshi, Wang, Weihu, Gao, Hengjun, Sun, Zhongsheng. Inter- and intratumor DNA methylation heterogeneity associated with lymph node metastasis and prognosis of esophageal squamous cell carcinoma. THERANOSTICS[J]. 2020, 10(7): 3035-3048, https://www.webofscience.com/wos/woscc/full-record/WOS:000514452800012.
[20] Zhang, Jianghong, Xue, Meiying, Mei, Yue, Li, Zhigang, Ceng, Zeng, Li, Yuanyuan, Zhang, Yi, Li, Na, Teng, Huajing, Sun, Zhong Sheng, Wang, Yan. Co-expression Network of mRNAs and lncRNAs Regulated by Stress-Linked Behavioral Assays. PSYCHOPHARMACOLOGY[J]. 2020, 237(2): 571-582, https://www.webofscience.com/wos/woscc/full-record/WOS:000498109500002.
[21] Miao, Zhuang, Wang, Yan, Sun, Zhongsheng. The Relationships Between Stress, Mental Disorders, and Epigenetic Regulation of BDNF. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2020, 21(4): https://doaj.org/article/fccd2f25888740fab1b65a6bb497a03b.
[22] Teng, Huajing, Wei, Wenqing, Li, Qinglan, Xue, Meiying, Shi, Xiaohui, Li, Xianfeng, Mao, Fengbiao, Sun, Zhongsheng. Prevalence and architecture of posttranscriptionally impaired synonymous mutations in 8,320 genomes across 22 cancer types. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(3): 1192-1205, https://www.webofscience.com/wos/woscc/full-record/WOS:000515121900021.
[23] Wang, Lin, Zhang, Yi, Li, Kuokuo, Wang, Zheng, Wang, Xiaomeng, Li, Bin, Zhao, Guihu, Fang, Zhenghuan, Ling, Zhengbao, Luo, Tengfei, Xia, Lu, Li, Yanping, Guo, Hui, Hu, Zhengmao, Li, Jinchen, Sun, Zhongsheng, Xia, Kun. Functional relationships between recessive inherited genes and genes with de novo variants in autism spectrum disorder. MOLECULAR AUTISM[J]. 2020, 11(1): http://dx.doi.org/10.1186/s13229-020-00382-x.
[24] 孙中生. The p21-activated kinases in synaptic cytoskeletal remodeling and related neurological disorders.. Protein & Cell. 2020, [25] Wang, Haoxuan, Wang, Tao, Zhao, Xiaolu, Wu, Honghu, You, Mingcong, Sun, Zhongsheng, Mao, Fengbiao. AI-Driver: an ensemble method for identifying driver mutations in personal cancer genomes. NAR GENOMICS AND BIOINFORMATICS[J]. 2020, 2(4): http://dx.doi.org/10.1093/nargab/lqaa084.
[26] Zhou, Hao, Xu, Xiu, Yan, Weili, Zou, Xiaobing, Wu, Lijie, Luo, Xuerong, Li, Tingyu, Huang, Yi, Guan, Hongyan, Chen, Xiang, Mao, Meng, Xia, Kun, Zhang, Lan, Li, Erzhen, Ge, Xiaoling, Zhang, Lili, Li, Chunpei, Zhang, Xudong, Zhou, Yuanfeng, Ding, Ding, Shih, Andy, Fombonne, Eric, Zheng, Yi, Han, Jisheng, Sun, Zhongsheng, Jiang, Yonghui, Wang, Yi, LATENTNHC Study Team. Prevalence of Autism Spectrum Disorder in China: A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years. NEUROSCIENCE BULLETIN[J]. 2020, 36(9): 961-971, http://lib.cqvip.com/Qikan/Article/Detail?id=7103003870.
[27] Miao, Zhuang, Zhang, Jianghong, Li, Yuanyuan, Li, Xianfeng, Song, Wei, Sun, Zhong Sheng, Wang, Yan. Presence of the pregnant partner regulates microRNA-30a and BDNF levels and protects male mice from social defeat-induced abnormal behaviors. NEUROPHARMACOLOGY[J]. 2019, 159: https://www.webofscience.com/wos/woscc/full-record/WOS:000493220100011.
[28] Li, Jinchen, Hu, Shanshan, Zhang, Kun, Shi, Leisheng, Zhang, Yi, Zhao, Tingting, Wang, Lin, He, Xin, Xia, Kun, Liu, Chunyu, Sun, Zhongsheng. A comparative study of the genetic components of three subcategories of autism spectrum disorder. MOLECULAR PSYCHIATRY[J]. 2019, 24(11): 1720-1731, [29] Yongqing Wang, Yan Wang, Jialong Liang, Wanshi Cai, Zhongsheng Sun, Yan Wang, Huajing Teng. Androgen deprivation drives variation of androgen receptor trinucleotide repeats. 生物化学与生物物理学报:英文版. 2019, 51(9): 972-975, http://lib.cqvip.com/Qikan/Article/Detail?id=7100194918.
[30] Wang, Yan, Wu, Haodo, Sun, Zhong Sheng. The biological basis of sexual orientation: How hormonal, genetic, and environmental factors influence to whom we are sexually attracted. FRONTIERS IN NEUROENDOCRINOLOGYnull. 2019, 55: [31] Chen, YueLei, Zhang, Yihe, Wang, Junwen, Chen, Na, Fang, Weiying, Zhong, Jianing, Liu, Yi, Qin, Rui, Yu, Xinxin, Sun, Zhongsheng, Gao, Fei. A 17 gene panel for non-small-cell lung cancer prognosis identified through integrative epigenomic-transcriptomic analyses of hypoxia-induced epithelial-mesenchymal transition. MOLECULAR ONCOLOGY[J]. 2019, 13(7): 1490-1502, https://doaj.org/article/f2bcf0153a7741a9b1f4613277b2293b.
[32] 孙中生. Genetic evidence of gender difference in autism spectrum disorder supports a female protective effect.. Translational Psychiatry. 2019, [33] Li, Xianfeng, Shi, Leisheng, Wang, Yan, Zhong, Jianing, Zhao, Xiaolu, Teng, Huajing, Shi, Xiaohui, Yang, Haonan, Ruan, Shasha, Li, MingKun, Sun, Zhong Sheng, Zhan, Qimin, Mao, Fengbiao. OncoBase: a platform for decoding regulatory somatic mutations in human cancers. NUCLEIC ACIDS RESEARCH[J]. 2019, 47(D1): D1044-D1055, [34] Li, Xianfeng, Shi, Leisheng, Zhang, Kun, Wei, Wenqing, Liu, Qi, Mao, Fengbiao, Li, Jinchen, Cai, Wanshi, Chen, Huiqian, Teng, Huajing, Li, Jiada, Sun, Zhongsheng. CirGRDB: a database for the genome-wide deciphering circadian genes and regulators. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(D1): D64-D70, https://www.webofscience.com/wos/woscc/full-record/WOS:000419550700011.
[35] Wang, Lin, Sun, Zhong Sheng, Xiang, Bingwu, Wei, Chiju, Wang, Yan, Sun, Kevin, Chen, Guanjie, Lan, Michael S, Carmona, Gilberto N, Notkins, Abner L, Cai, Tao. Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance. JOURNAL OF TRANSLATIONAL MEDICINE[J]. 2018, 16(1): https://doaj.org/article/4f93136204af45539819c336a08ee249.
[36] Liang, Jialong, Cai, Wanshi, Feng, Dongdong, Teng, Huajing, Mao, Fengbiao, Jiang, Yi, Hu, Shanshan, Li, Xianfeng, Zhang, Yujie, Liu, Baoguo, Sun, Zhong Sheng. Genetic landscape of papillary thyroid carcinoma in the Chinese population. JOURNAL OF PATHOLOGY[J]. 2018, 244(2): 215-226, https://www.webofscience.com/wos/woscc/full-record/WOS:000422751200009.
[37] Miao, Zhuang, Mao, Fengbiao, Liang, Jialong, Szyf, Moshe, Wang, Yan, Sun, Zhong Sheng. Anxiety-Related Behaviours Associated with microRNA-206-3p and BDNF Expression in Pregnant Female Mice Following Psychological Social Stress. MOLECULAR NEUROBIOLOGY[J]. 2018, 55(2): 1097-1111, [38] Wang, Yan, Zeng, Cheng, Li, Jinchen, Zhou, Zikai, Ju, Xingda, Xia, Shuting, Li, Yuanyuan, Liu, An, Teng, Huajing, Zhang, Kun, Shi, Leisheng, Bi, Cheng, Xie, Wei, He, Xin, Jia, Zhengping, Jiang, Yonghui, Cai, Tao, Wu, Jinyu, Xia, Kun, Sun, Zhong Sheng. PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior. CELL REPORTS[J]. 2018, 24(8): 2029-2041, http://dx.doi.org/10.1016/j.celrep.2018.07.061.
[39] Zhang, Hang, Cai, Wanshi, Chen, Siyu, Liang, Jialong, Wang, Zhanjun, Ren, Yuting, Liu, Wenxiu, Zhang, Xiaolan, Sun, Zhongsheng, Huang, Xusheng. Screening for possible oligogenic pathogenesis in Chinese sporadic ALS patients. AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION[J]. 2018, 19(5-6): 419-425, https://www.webofscience.com/wos/woscc/full-record/WOS:000435582800011.
[40] Wu, Jinyu, Yu, Ping, Jin, Xin, Xu, Xiu, Li, Jinchen, Li, Zhongshan, Wang, Mingbang, Wang, Tao, Wu, Xueli, Jiang, Yi, Cai, Wanshi, Mei, Junpu, Min, Qingjie, Xu, Qiong, Zhou, Bingrui, Guo, Hui, Wang, Ping, Zhou, Wenhao, Hu, Zhengmao, Li, Yingrui, Cai, Tao, Wang, Yi, Xia, Kun, Jiang, YongHui, Sun, Zhong Sheng. Genomic landscapes of Chinese sporadic autism spectrum disorders revealed by whole-genome sequencing. JOURNAL OF GENETICS AND GENOMICS[J]. 2018, 45(10): 527-538, http://lib.cqvip.com/Qikan/Article/Detail?id=676889504.
[41] Jie Yang, Yun Chen, Jingxiao Lu, Xingxing Wang, Lu Wang, Jialong Liang, Zhong Sheng Sun. Identification and characterization of novel fusion genes in prostate cancer by targeted RNA capture and next-generation sequencing. 生物化学与生物物理学报:英文版[J]. 2018, 50(11): 1166-1172, http://lib.cqvip.com/Qikan/Article/Detail?id=6100232413.
[42] Teng, Huajing, Mao, Fengbiao, Liang, Jialong, Xue, Meiying, Wei, Wenqing, Li, Xianfeng, Zhang, Kun, Feng, Dongdong, Liu, Baoguo, Sun, Zhongsheng. Transcriptomic signature associated with carcinogenesis and aggressiveness of papillary thyroid carcinoma. THERANOSTICS[J]. 2018, 8(16): 4345-4358, http://dx.doi.org/10.7150/thno.26862.
[43] Li, Jinchen, Shi, Leisheng, Zhang, Kun, Zhang, Yi, Hu, Shanshan, Zhao, Tingting, Teng, Huajing, Li, Xianfeng, Jiang, Yi, Ji, Liying, Sun, Zhongsheng. VarCards: an integrated genetic and clinical database for coding variants in the human genome. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(D1): D1039-D1048, https://www.webofscience.com/wos/woscc/full-record/WOS:000419550700151.
[44] Li, Jinchen, Zhao, Tingting, Zhang, Yi, Zhang, Kun, Shi, Leisheng, Chen, Yun, Wang, Xingxing, Sun, Zhongsheng. Performance evaluation of pathogenicity-computation methods for missense variants. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(15): 7793-7804, http://dx.doi.org/10.1093/nar/gky678.
[45] Mao, Fengbiao, Liu, Qi, Zhao, Xiaolu, Yang, Haonan, Guo, Sen, Xiao, Luoyuan, Li, Xianfeng, Teng, Huajing, Sun, Zhongsheng, Dou, Yali. EpiDenovo: a platform for linking regulatory de novo mutations to developmental epigenetics and diseases. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(D1): D92-D99, https://www.webofscience.com/wos/woscc/full-record/WOS:000419550700015.
[46] Yue Mei, Jianghong Zhang, Zhigang Li, Huajing Teng, Yan Wang, Zhongsheng Sun. Altered expressions of memory genes in food-entrained circadian rhythm. 生物化学与生物物理学报：英文版. 2018, 50(10): 1068-1071, http://lib.cqvip.com/Qikan/Article/Detail?id=676886736.
[47] Teng, Huajing, Zhang, Yaohua, Shi, Chengmin, Mao, Fengbiao, Cai, Wanshi, Lu, Liang, Zhao, Fangqing, Sun, Zhongsheng, Zhang, Jianxu. Population Genomics Reveals Speciation and Introgression between Brown Norway Rats and Their Sibling Species. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2017, 34(9): 2214-2228, https://www.webofscience.com/wos/woscc/full-record/WOS:000408307400008.
[48] Wang, Yan, Liu, Huijie, Sun, Zhongsheng. Lamarck rises from his grave: parental environment-induced epigenetic inheritance in model organisms and humans. BIOLOGICAL REVIEWSnull. 2017, 92(4): 2084-2111, https://www.webofscience.com/wos/woscc/full-record/WOS:000412314400012.
[49] Guo, Sen, Yang, Liu, Liu, Huijie, Chen, Wei, Li, Jinchen, Yu, Ping, Sun, Zhong Sheng, Chen, Xiang, Du, Jie, Cai, Tao. Identification of Novel Compound Mutations in PLA2G6-Associated Neurodegeneration Patient with Characteristic MRI Imaging. MOLECULAR NEUROBIOLOGY[J]. 2017, 54(6): 4636-4643, https://www.webofscience.com/wos/woscc/full-record/WOS:000405710900057.
[50] Li, Jinchen, Wang, Lin, Yu, Ping, Shi, Leisheng, Zhang, Kun, Sun, Zhong Sheng, Xia, Kun. Vitamin D-related genes are subjected to significant de novo mutation burdens in autism spectrum disorder. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS[J]. 2017, 174(5): 568-577, https://www.webofscience.com/wos/woscc/full-record/WOS:000403502500005.
[51] Zhong, Jianing, Li, Xianfeng, Cai, Wanshi, Wang, Yan, Dong, Shanshan, Yang, Jie, Zhang, Jianan, Wu, Nana, Li, Yuanyuan, Mao, Fengbiao, Zeng, Cheng, Wu, Jinyu, Xu, Xingzhi, Sun, Zhong Sheng. TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function. NUCLEIC ACIDS RESEARCH[J]. 2017, 45(2): 672-684, [52] Wang, Jiesi, Zhang, Ke, Chen, Xiaojuan, Liu, Xiaoqian, Teng, Huajing, Zhao, Mei, Sun, Zhongsheng, Mei Zhao, Zhongsheng Sun. Epigenetic Activation of ASCT2 in the Hippocampus Contributes to Depression-Like Behavior by Regulating D-Serine in Mice. FRONTIERS IN MOLECULAR NEUROSCIENCE[J]. 2017, 10: http://dx.doi.org/10.3389/fnmol.2017.00139.
[53] 孙中生. A Web Server for Prioritizations of Pathogenic Sequence Variants from Exome Sequencing Data via Classifications.. Human Mutation. 2017, [54] Li, Zhongshan, Liu, Zhenwei, Jiang, Yi, Chen, Denghui, Ran, Xia, Sun, Zhong Sheng, Wu, Jinyu. mirVAFC: A Web Server for Prioritizations of Pathogenic Sequence Variants from Exome Sequencing Data via Classifications. HUMAN MUTATION[J]. 2017, 38(1): 25-33, https://www.webofscience.com/wos/woscc/full-record/WOS:000390349700003.
[55] Zhong, Jianing, Ji, Liying, Chen, Huiqian, Li, Xianfeng, Zhang, Jianan, Wang, Xingxing, Wu, Weilin, Xu, Ying, Huang, Fei, Cai, Wanshi, Sun, Zhong Sheng. Acetylation of hMOF Modulates H4K16ac to Regulate DNA Repair Genes in Response to Oxidative Stress. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2017, 13(7): 923-934, https://www.webofscience.com/wos/woscc/full-record/WOS:000408370300010.
[56] Li, Jinchen, Wang, Lin, Guo, Hui, Shi, Leisheng, Zhang, Kun, Tang, Meina, Hu, Shanshan, Dong, Shanshan, Liu, Yanling, Wang, Tianyun, Yu, Ping, He, Xin, Hu, Zhengmao, Zhao, Jinping, Liu, Chunyu, Sun, Zhong Sheng, Xia, Kun. Targeted sequencing and functional analysis reveal brain-size-related genes and their networks in autism spectrum disorders. MOLECULAR PSYCHIATRY[J]. 2017, 22(9): 1282-1290, https://www.webofscience.com/wos/woscc/full-record/WOS:000408191000008.
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[72] Li, Zhigang, Wang, Yan, Sun, Kevin Kai, Wang, Kangli, Sun, Zhong Sheng, Zhao, Mei, Wang, Jundong. Sex-related difference in food-anticipatory activity of mice. HORMONES AND BEHAVIOR[J]. 2015, 70: 38-46, http://dx.doi.org/10.1016/j.yhbeh.2015.02.004.
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[74] Nemoda, Z, Massart, R, Suderman, M, Hallett, M, Li, T, Coote, M, Cody, N, Sun, Z S, Soares, C N, Turecki, G, Steiner, M, Szyf, M. Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi. TRANSLATIONAL PSYCHIATRY[J]. 2015, 5: e545-, http://dx.doi.org/10.1038/tp.2015.32.
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[76] Wang, Jiesi, Luo, YongLun, Wang, KangLi, Wang, Yan, Zhang, Xiaolin, Teng, Huajing, Sun, Zhongsheng. Clock-controlled StAR's expression and corticosterone production contribute to the endotoxemia immune response. CHRONOBIOLOGY INTERNATIONAL[J]. 2015, 32(3): 358-367, [77] Qing Xie, Qi Liu, Fengbiao Mao, Wanshi Cai, Honghu Wu, Mingcong You, Zhen Wang, Bingyu Chen, Zhong Sheng Sun, Jinyu Wu. A Bayesian Framework to Identify Methylcytosines from High-Throughput Bisulfite Sequencing Data. PLOS COMPUTATIONAL BIOLOGY[J]. 2014, 10(9): http://dx.doi.org/10.1371/journal.pcbi.1003853.
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[81] 孙中生. Identification of a novel missense (C7W) mutation of SOD1 in a large familial amyotrophic lateral sclerosis pedigree.. 2013, [82] Wu, Jinyu, Liu, Qi, Wang, Xin, Zheng, Jiayong, Wang, Tao, You, Mingcong, Sun, Zhong Sheng, Shi, Qinghua. mirTools 2.0 for non-coding RNA discovery, profiling and functional annotation based on high-throughput sequencing. RNA BIOLOGY[J]. 2013, 10(7): 1087-1092, https://www.webofscience.com/wos/woscc/full-record/WOS:000327572300007.
[83] 孙中生. Mutations of ANK3 identified by exome sequencing are associated with autism ausceptibility.. 2012, [84] Zhang, Jing, Li, Huili, Teng, Huajing, Zhang, Ting, Luo, Yonglun, Zhao, Mei, Li, YunQing, Sun, Zhong Sheng, Sun, ZS reprint author, Chinese Acad Sci, Beijing Inst Life Sci, BeiChen W Rd, Beijing, Peoples R China. Regulation of Peripheral Clock to Oscillation of Substance P Contributes to Circadian Inflammatory Pain. ANESTHESIOLOGY[J]. 2012, 117(1): 149-160, http://www.irgrid.ac.cn/handle/1471x/970984.
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（1） 抑制DNA去甲基化作为肝癌治疗新策略的机制，主持，国家级，2012-01--2014-12
（2） 表观基因组、转录组技术平台的搭建和优化，主持，国家级，2012-01--2015-12
（3） 抑郁症母亲影响子代行为的表观遗传标志物全基因组扫描，主持，国家级，2011-01--2013-12
（4） 精神分裂症和抑郁症的环境和表观遗传发病机理研究，参与，国家级，2007-06--2011-07

已指导学生

王彦  博士研究生  040221-认知神经科学  

罗永伦  硕士研究生  040222-行为遗传学  

马云霞  硕士研究生  040222-行为遗传学  

张靖  博士研究生  077122-行为遗传学  

刘帅  硕士研究生  077122-行为遗传学  

王杰思  硕士研究生  077122-行为遗传学  

现指导学生

王永庆  博士研究生  040222-行为遗传学  

王嫣  博士研究生  040222-行为遗传学  

毕澄  博士研究生  040222-行为遗传学  

毛凤彪  硕士研究生  071007-遗传学  

王杰思  博士研究生  071007-遗传学  

蔡万世  博士研究生  071007-遗传学  

梁加龙  硕士研究生  071007-遗传学  

苗壮  博士研究生  071007-遗传学