基本信息
朱明昭  男  博导  中国科学院生物物理研究所
电子邮件: zhumz@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码: 100101

招生信息

   
招生专业
071009-细胞生物学
100102-免疫学
招生方向
淋巴组织微环境和T细胞的发育和功能
疫苗免疫学

教育背景

1998-09--2003-07   中国医学科学院基础医学研究所   博士
1994-09--1998-07   北京大学生命科学学院   学士
学历
中国医学科学院基础医学研究所 -- 研究生
学位
中国医学科学院基础医学研究所 -- 博士

工作经历

   
工作简历
2009-10~现在, 中国科学院生物物理研究所, 研究员
2009-01~2009-12,芝加哥大学, 研究助理教授
2004-01~2008-12,芝加哥大学, 博士后

教授课程

分子与细胞免疫学
科研论文写作
科研实践I
抗体技术及应用
抗感免疫学
分子免疫学

专利与奖励

   
奖励信息
(1) 国家杰出青年科学基金, 国家级, 2020
(2) 中科院“****”, , 部委级, 2010
专利成果
( 1 ) 聚乙二醇化磷脂为载体的胶束多肽疫苗, 发明专利, 2018, 第 2 作者, 专利号: CN201410570624.7

出版信息

发表论文
[1] Zhu, Mingzhao. Immunological perspectives on spatial and temporal vaccine delivery. ADVANCED DRUG DELIVERY REVIEWSnull. 2021, 178: http://dx.doi.org/10.1016/j.addr.2021.113966.
[2] Wenjun Wang, Baoying Huang, Yanping Zhu, Wenjie Tan, Mingzhao Zhu. Ferritin nanoparticle-based SARS-CoV-2 RBD vaccine induces a persistent antibody response and long-term memory in mice. CELLULAR & MOLECULAR IMMUNOLOGYnull. 2021, 18(3): 749-751, https://www.webofscience.com/wos/woscc/full-record/WOS:000617407500003.
[3] Hongxia Duan, Xiyun Yan, Mingzhao Zhu. CD146 bound to LCK promotes TCR signaling and anti-tumor immune response in mice. J Clin Invest.[J]. 2021, [4] Huan Xia, Suijuan Zhong, Yixiao Zhao, Boyang Ren, Zhongnan Wang, Yaoyao Shi, Qian Chai, Xiaoqun Wang, Mingzhao Zhu. Thymic Egress Is Regulated by T Cell-Derived LTβR Signal and via Distinct Thymic Portal Endothelial Cells. Frontiers in Immunology[J]. 2021, 12: PMC_JournalArticle.
[5] Pian, Yaya, Chai, Qian, Ren, Boyang, Wang, Yue, Lv, Mengjie, Qiu, Ju, Zhu, Mingzhao. Type 3 Innate Lymphoid Cells Direct Goblet Cell Differentiation via the LT-LT beta R Pathway during Listeria Infection. JOURNAL OF IMMUNOLOGY[J]. 2020, 205(3): 853-863, http://dx.doi.org/10.4049/jimmunol.2000197.
[6] Long, Haizhen, Zhang, Liwei, Lv, Mengjie, Wen, Zengqi, Zhang, Wenhao, Chen, Xiulan, Zhang, Peitao, Li, Tongqing, Chang, Luyuan, Jin, Caiwei, Wu, Guozhao, Wang, Xi, Yang, Fuquan, Pei, Jianfeng, Chen, Ping, Margueron, Raphael, Deng, Haiteng, Zhu, Mingzhao, Li, Guohong. H2A.Z facilitates licensing and activation of early replication origins. NATURE[J]. 2020, 577(7791): 576-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000507800800003.
[7] Wang, Wenjun, Zhou, Xiaoxiao, Bian, Yingjie, Wang, Shan, Chai, Qian, Guo, Zhenqian, Wang, Zhenni, Zhu, Ping, Peng, Hua, Yan, Xiyun, Li, Wenhui, Fu, YangXin, Zhu, Mingzhao. Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B. NATURE NANOTECHNOLOGY[J]. 2020, 15(5): 406-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000517740500002.
[8] Ge, Qing, Zhang, Xinwei. TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via MEK/ERK signaling pathway. JOURNAL OF IMMUNOLOGYnull. 2019, 202(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000524982500038.
[9] Wang, Wenjun, Liu, Zhida, Zhou, Xiaoxiao, Guo, Zhenqian, Zhang, Jing, Zhu, Ping, Yao, Sheng, Zhu, Mingzhao. Ferritin nanoparticle-based SpyTag/SpyCatcher-enabled click vaccine for tumor immunotherapy. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE[J]. 2019, 16: 69-78, http://dx.doi.org/10.1016/j.nano.2018.11.009.
[10] Mingzhao Zhu PhD. Langerhans cells control lymphatic vessel function during inflammation via direct LIGHT-LTbR signaling. Journal of Immunology. 2019, [11] Yang, Rui, Wang, Huanmin, Kang, Boxi, Chen, Bin, Shi, Yaoyao, Yang, Shuchun, Sun, Lihong, Liu, Yufang, Xiao, Weidi, Zhang, Tao, Yang, Juntao, Zhang, Ye, Zhu, Mingzhao, Xu, Ping, Chang, Yongsheng, Jia, Yuyan, Huang, Yue. CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. DEVELOPMENT[J]. 2019, 146(2): http://dx.doi.org/10.1242/dev.169235.
[12] Yang, Kaiting, Liang, Yong, Sun, Zhichen, Liu, Longchao, Liao, Jing, Xu, Hairong, Zhu, Mingzhao, Fu, YangXin, Peng, Hua. T cell-derived lymphotoxin limits Th1 response during HSV-1 infection. SCIENTIFIC REPORTS[J]. 2018, 8(1): https://doaj.org/article/25c58b45ade94631877a8476447b07e0.
[13] Yang, Kaiting, Liang, Yong, Sun, Zhichen, Xue, Diyuan, Xu, Hairong, Zhu, Mingzhao, Fu, YangXin, Peng, Hua. T Cell-Derived Lymphotoxin Is Essential for the Anti-Herpes Simplex Virus 1 Humoral Immune Response. JOURNAL OF VIROLOGY[J]. 2018, 92(14): https://www.webofscience.com/wos/woscc/full-record/WOS:000437375800024.
[14] Mingzhao Zhu PhD. Differential roles of LTbR in endothelial cell subsets for lymph node organogenesis and maturation. Journal of Immunology. 2018, [15] Xiaopeng Qi, Lin Jin, ChengFeng Qin, Jingya Guo, Mingzhao Zhu, Gong Cheng, Chunmiao Hu Ombati Rose, Tao Xu, Pengpeng Li, Peng Sun, Xue Hao, Ren Lai, Chuanbin Shen, Hongning Zhou, Mingdong Yang, Hua Peng. Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor. Nature Immunology[J]. 2018, 342–353-, http://159.226.149.26:8080/handle/152453/12263.
[16] Caiwei Jin, Mingzhao Zhu. RelB intrinsically regulates the development and function of medullary thymic epithelial cells. 中国科学:生命科学英文版. 2018, 61(9): 1039-1048, http://lib.cqvip.com/Qikan/Article/Detail?id=676288668.
[17] Fu, YangXin, Liu, Xiaojuan. Dual targeting of innate and adaptive checkpoints on tumor cells limits immune evasion. CANCER RESEARCHnull. 2018, 78(13): https://www.webofscience.com/wos/woscc/full-record/WOS:000468819503192.
[18] Liu, Zhida, Zhou, Chang, Qin, Yan, Wang, Zihao, Wang, Luyao, Wei, Xiuli, Zhou, Yinjian, Li, Qicheng, Zhou, Hang, Wang, Wenjun, Fu, YangXin, Zhu, Mingzhao, Liang, Wei. Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine. CELL DISCOVERY[J]. 2017, 3: 17007-, https://www.webofscience.com/wos/woscc/full-record/WOS:000414904200001.
[19] Wu, Weiwei, Shi, Yaoyao, Xia, Huan, Chai, Qian, Jin, Caiwei, Ren, Boyang, Zhu, Mingzhao. Epithelial LT beta R signaling controls the population size of the progenitors of medullary thymic epithelial cells in neonatal mice. SCIENTIFIC REPORTS[J]. 2017, 7: https://www.webofscience.com/wos/woscc/full-record/WOS:000396122000002.
[20] Jing Wang, Pupu Ge, Lihua Qiang, Feng Tian, Dongdong Zhao, Qiyao Chai, Mingzhao Zhu, Rongbin Zhou, Guangxun Meng, Yoichiro Iwakura, George Fu Gao, Cui Hua Liu. The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/465a63bc5e6745cab574ea4a454e9961.
[21] Mingzhao Zhu PhD. LTbR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration. Nature Communications. 2016, [22] Liu, Zhida, Zhou, Hang, Wang, Wenjun, Fu, YangXin, Zhu, Mingzhao. A novel dendritic cell targeting HPV16 E7 synthetic vaccine in combination with PD-L1 blockade elicits therapeutic antitumor immunity in mice. ONCOIMMUNOLOGY[J]. 2016, 5(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000379162700011.
[23] Lv, Mengjie, Wu, Weiwei, Zhang, Yuejiao, Zhu, Mingzhao. Herpes virus entry mediator licenses Listeria infection induced immunopathology through control of type I interferon. SCIENTIFIC REPORTS[J]. 2015, 5: https://www.webofscience.com/wos/woscc/full-record/WOS:000359127700001.
[24] Liu, Zhida, Zhou, Hang, Wang, Wenjun, Tan, Wenjie, Fu, YangXin, Zhu, Mingzhao. A novel method for synthetic vaccine construction based on protein assembly. SCIENTIFIC REPORTS[J]. 2014, 4: https://www.webofscience.com/wos/woscc/full-record/WOS:000346257900002.
[25] Shi YaoYao, Zhu MingZhao. Medullary thymic epithelial cells, the indispensable player in central tolerance. SCIENCE CHINA-LIFE SCIENCESnull. 2013, 56(5): 392-398, http://www.irgrid.ac.cn/handle/1471x/756678.
[26] Mingzhao Zhu, Yangxin Fu. Proinflammatory IL-17 induces iBALT development. 中国免疫学杂志:英文版. 2012, 9(2): 101-102, http://lib.cqvip.com/Qikan/Article/Detail?id=41331132.
[27] Zhu, Mingzhao, Yang, Yajun, Wang, Yugang, Wang, Zhongnan, Fu, YangXin. LIGHT Regulates Inflamed Draining Lymph Node Hypertrophy. JOURNAL OF IMMUNOLOGY[J]. 2011, 186(12): 7156-7163, http://www.irgrid.ac.cn/handle/1471x/757296.
[28] Zhu, Mingzhao, Fu, YangXin. Deflating the Lymph Node. IMMUNITYnull. 2011, 34(1): 8-10, http://dx.doi.org/10.1016/j.immuni.2011.01.005.
[29] Zhu, Mingzhao, Fu, YangXin. The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling. IMMUNOLOGICAL REVIEWSnull. 2011, 244: 75-84, http://www.irgrid.ac.cn/handle/1471x/757567.
[30] Zhu, Mingzhao, Brown, Nicholas K, Fu, YangXin. Direct and indirect roles of the LT beta R pathway in central tolerance induction. TRENDS IN IMMUNOLOGYnull. 2010, 31(9): 325-331, http://www.irgrid.ac.cn/handle/1471x/757279.
[31] Zhu, Mingzhao, Fu, Yangxin. The complicated role of NF-kappa B in T-cell selection. CELLULAR & MOLECULAR IMMUNOLOGYnull. 2010, 7(2): 89-93, http://www.irgrid.ac.cn/handle/1471x/757271.
[32] Wang, Yugang, Zhu, Mingzhao, Yu, Ping, Fu, YangXin. Promoting Immune Responses by LIGHT in the Face of Abundant Regulatory T Cell Inhibition. JOURNAL OF IMMUNOLOGY[J]. 2010, 184(3): 1589-1595, https://www.webofscience.com/wos/woscc/full-record/WOS:000273956400053.
[33] Wang, Yugang, Zhu, Mingzhao, Miller, Mendy, Fu, YangXin. Immunoregulation by tumor necrosis factor superfamily member LIGHT. IMMUNOLOGICAL REVIEWSnull. 2009, 229(1): 232-243, https://www.webofscience.com/wos/woscc/full-record/WOS:000265409800015.
[34] Zhu, Mingzhao, Fu, YangXin. Coordinating development of medullary thymic epithelial cells. IMMUNITYnull. 2008, 29(3): 386-388, http://dx.doi.org/10.1016/j.immuni.2008.09.001.
[35] Zhu, Mingzhao, Chin, Robert K, Tumanov, Alexei V, Liu, Xiaojuan, Fu, YangXin. Lymphotoxin beta receptor is required for the migration and selection of autoreactive T cells in thymic medulla. JOURNAL OF IMMUNOLOGY[J]. 2007, 179(12): 8069-8075, https://www.webofscience.com/wos/woscc/full-record/WOS:000251590000010.
[36] Zhu, Mingzhao, Chin, Robert K, Christiansen, Peter A, Lo, James C, Liu, Xiaojuan, Ware, Carl, Siebenlist, Ulrich, Fu, YangXin. NF-kappa B2 is required for the establishment of central tolerance through an Aire-dependent pathway. JOURNAL OF CLINICAL INVESTIGATION[J]. 2006, 116(11): 2964-2971, https://www.webofscience.com/wos/woscc/full-record/WOS:000241810900020.
[37] Tang Haidong, Zhu Mingzhao, Qiao Jian, Fu Yang-Xin. Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy. Cellular and Molecular Immunology. 14(10): 809-818, https://www.webofscience.com/wos/woscc/full-record/WOS:000412979200005.
发表著作
(1) 自身免疫病的表观遗传学, The Epigenetics of Autoimmune Diseases, John Wiley Sons, Inc., 2009-07, 第 1 作者

科研活动

   
科研项目
( 1 ) 发育中胸腺上皮细胞和胸腺细胞间的相互作用, 主持, 国家级, 2011-01--2015-12
( 2 ) LIGHT调节树突状细胞向淋巴结迁移的细胞和分子机制, 主持, 国家级, 2011-01--2013-12
( 3 ) 淋巴管-细胞迁移和免疫调节的新靶点, 主持, 国家级, 2012-01--2014-12
( 4 ) LTbR在胸腺重建中的作用及其细胞和分子机制的研究, 主持, 国家级, 2014-01--2017-12
( 5 ) LTin细胞的发育、功能及其调控机制研究, 主持, 国家级, 2016-01--2019-12
( 6 ) EGFR单抗-I型干扰素肿瘤靶向药物个性化特征的研究, 主持, 部委级, 2016-01--2018-12
( 7 ) 胸腺血管内皮细胞调控胸腺细胞迁出的细胞和分子机制, 主持, 国家级, 2018-01--2021-12
( 8 ) 肿瘤免疫治疗抗体研发, 主持, 院级, 2017-10--2020-09
( 9 ) 基于新型纳米材料肿瘤疫苗新技术的研发和应用, 主持, 部委级, 2019-01--2020-06
( 10 ) 新型免疫调节药物的研究, 参与, 部委级, 2019-01--2020-12
( 11 ) 信号诱导细胞记忆的表观遗传机制, 参与, 国家级, 2019-07--2024-06
( 12 ) 免疫调控线路及器 件的合成生物学研究, 主持, 国家级, 2020-01--2024-12
( 13 ) 淋巴结靶向递送的免疫机制研究, 主持, 国家级, 2020-01--2024-12
( 14 ) 适应性免疫系统的发育和应答, 主持, 国家级, 2021-01--2025-12

指导学生

已指导学生

吕梦捷  博士研究生  071009-细胞生物学  

刘志达  博士研究生  071009-细胞生物学  

伍伟伟  博士研究生  071009-细胞生物学  

史瑶瑶  博士研究生  071009-细胞生物学  

金采薇  博士研究生  071009-细胞生物学  

王文君  博士研究生  071009-细胞生物学  

赵艺晓  硕士研究生  085238-生物工程  

王中南  博士研究生  071009-细胞生物学  

夏欢  博士研究生  071009-细胞生物学  

周航  博士研究生  071009-细胞生物学  

任博阳  博士研究生  071009-细胞生物学  

廖伊君  硕士研究生  077802-免疫学  

现指导学生

赵艺晓  博士研究生  071009-细胞生物学  

梁伟  博士研究生  071009-细胞生物学  

詹明高  博士研究生  071009-细胞生物学  

梁安坪  硕士研究生  071009-细胞生物学  

周晓晓  博士研究生  071009-细胞生物学  

曹香香  硕士研究生  071009-细胞生物学  

张婧  硕士研究生  071010-生物化学与分子生物学  

谭心怡  硕士研究生  071009-细胞生物学  

郑艺圆  硕士研究生  071009-细胞生物学  

张邦民  博士研究生  071009-细胞生物学  

丁继宇  博士研究生  071009-细胞生物学  

吕之晗  硕士研究生  071009-细胞生物学  

郑舒婷  博士研究生  071009-细胞生物学