表观遗传调控影响DNA复制、基因转录、DNA损伤修复、基因组稳定性维持等重要生物学事件，并与癌症、自体免疫等疾病密切相关。染色质由DNA和组蛋白组成，染色质结构的动态变化决定DNA的开放和关闭状态，构成表观遗传调控的分子基础。染色质结构的异常导致表观遗传调控错误并导致疾病。研究染色质结构变化规律对于揭示表观遗传机制以及相关的疾病研究具有重要的理论意义和临床应用价值。

　　组蛋白是染色质的重要组成原件，是表观遗传调控的重要参与者。组蛋白在基因组上的装配、移除、交换等变化会造成染色质结构的变化，组蛋白在细胞内的修饰、转运、存贮等过程受到组蛋白伴侣、组蛋白修饰酶、染色质重塑复合物等表观因子的调控。本课题组主要研究组蛋白在染色质结构变化与表观遗传调控中的功能，主要方向包括：（1）染色质组装（2）染色质结构维持（3）组蛋白变体和修饰的识别。本课题组利用多种结构生物学手段，并结合生物化学、生物物理学、酵母遗传学等方法进行研究。

  主页：http://www.ibp.cas.cn/ktzz/ktzz_Z/201308/t20130829_3920653.html, Email:zhouzh@ibp.ac.cn, Tel:010-64889862，

欢迎对表观遗传和结构生物学研究感兴趣的同学加入我们的集体！

071010-生物化学与分子生物学
071007-遗传学
071011-生物物理学

染色质结构及表观调控
结构生物学
蛋白质工程

1999-09--2003-08   中科院上海生物化学与细胞生物学研究所   理学博士
1992-09--1999-07   湖南师范大学   理学学士硕士

   

2008-09~2011-09,美国国立健康研究院癌症研究所, Research Fellow
2003-09~2008-09,美国国立健康研究院癌症研究所, Visiting Fellow

2018-08-01-2021-10-31,中国生物物理学会11届理事会, 会员工作委员会主任
2017-11-30-今,《生命科学研究》学术期刊, 编委

结构生物学技术
细胞的物理生物学
高等生物物理学

   

   

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（1） 蛋白质折叠方法学：利用氢氘交换介导的蛋白质工程富集蛋白折叠中间体及利用核磁共振进行结构研究, Protein folding protocols: Population and structure determination of hidden folding intermediates by native-state hydrogen exchange-directed protein engineering and nuclear magnetic resonance, Humana Press, 2006-02, 第 3 作者

   

（ 1 ） 组蛋白变体结构及其参与的表观遗传调控机理研究, 主持, 国家级, 2012-01--2015-12
（ 2 ） 组蛋白二聚体的动态结构及其生物学功能研究, 主持, 国家级, 2013-01--2016-12
（ 3 ） 表观遗传信息建立与解读的分子基础, 参与, 国家级, 2015-01--2016-08
（ 4 ） 染色质结构及其调控, 参与, 国家级, 2016-01--2021-12
（ 5 ） 染色质重构复合物SRCAP/SWR1介导的H2A.Z染色质组装机制研究, 主持, 国家级, 2017-01--2020-12

（1）Preferential recognition of H2A.Z-H2B by Mps3 direct DNA double-strand breaks to nuclear periphery   2017-09-06
（2）Structural basis of H2A.Z recognition by SRCAP subunit YL1   2016-07-28
（3）Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1   Zheng Zhou   2016-05-09
（4）Structural basis of H2A.Z recognition by its chaperones   2016-04-09
（5）Structural study of H2A.Z specific histone chaperone   2014-08-04
（6）Structural basis for recognition of centromere specific histone H3 variant by nonhistone Scm3   Zheng Zhou, Hanqiao Feng, Yawen Bai   2010-03-01

已指导学生

梁小平  博士研究生  071010-生物化学与分子生物学  

潘露  博士研究生  071010-生物化学与分子生物学  

王云云  博士研究生  071010-生物化学与分子生物学  

谢晓燕  博士研究生  071010-生物化学与分子生物学  

周驹俊  博士研究生  071010-生物化学与分子生物学  

吴飞  硕士研究生  085238-生物工程  

戴亚鑫  博士研究生  071010-生物化学与分子生物学  

黄艳  博士研究生  071010-生物化学与分子生物学  

现指导学生

黄莉  博士研究生  071010-生物化学与分子生物学  

周宁  博士研究生  071010-生物化学与分子生物学  

谌姣  博士研究生  071010-生物化学与分子生物学  

周英博  硕士研究生  077802-免疫学  

史刘歆  博士研究生  071010-生物化学与分子生物学  

王龙歌  博士研究生  071010-生物化学与分子生物学  

朱浩强  博士研究生  071010-生物化学与分子生物学