基本信息
钟瑾  女  博导  中国科学院微生物研究所
电子邮件: zhongj@im.ac.cn
通信地址: 北京朝阳区北辰西路1号院3号
邮政编码: 100101

研究领域

    乳酸菌(Lactic Acid Bacteria, LAB)是一类能代谢产乳酸的细菌的总称,它们广泛应用于食品行业,也是肠道等重要的益生菌,还具备产生多种抗菌多肽的能力。因安全、耐酸及肠道定殖力等,乳酸菌还是酶及疫苗抗原良好的口服呈递载体。本研究组主要从事乳酸菌分子遗传及资源利用研究,具体包括:(1)乳酸菌生物活性产物如细菌素的生物合成、代谢调控、作用机制、结构功能等研究;(2)益生菌的益生分子机制研究;(3)肠道/生殖道及发酵食品/饲料的功能微生物组解析及调控研究;(4)功能乳酸菌及其代谢产物在健康、食品和农业等领域的应用基础研究等。

招生信息

   
招生专业
071007-遗传学
085238-生物工程
招生方向
乳酸菌分子遗传学
乳酸菌分子遗传工程

教育背景

1999-09--2003-07   北京大学生命科学学院   博士

工作经历

工作简历
2011-07~现在, 中科院微生物研究所, 研究员
2009-10~现在, 中科院微生物所, 课题组长
2008-12~2011-07,中科院微生物所, 副研究员
2003-09~2008-12,中科院微生物所, 助理研究员

教授课程

普通生物学实验
微生物遗传与分子生物学
微生物学实验技术

专利与奖励


奖励信息
(1) 全国巾帼建功标兵, , 国家级, 2021
(2) 中科院科技促进发展奖, , 院级, 2020
(3) 中科院年度人物, , 院级, 2020
(4) 《微生物学报》优秀编委, , 其他, 2020
(5) 中科院大学生命科学学院精品课程, , 院级, 2019
(6) 《微生物学报》优秀编委, 其他, 2018
专利成果
[1] 钟瑾, 王天威, 曹艳红, 骆爱群, 宣泽义. 一种发酵马蹄渣及其制备方法与应用. CN: CN111838406A, 2020-10-30.

[2] 钟瑾, 王天威, 曹艳红, 骆爱群, 宣泽义. 一种发酵罗汉果渣及其制备方法与应用. CN: CN111718879A, 2020-09-29.

[3] 钟瑾, 王天威, 曹艳红, 骆爱群, 宣泽义. 一种复合乳酸菌剂及其在甘蔗尾叶青贮中的应用. CN: CN111534456A, 2020-08-14.

[4] 钟瑾, 骆爱群, 苏日娜, 倪奎奎, 陶勇. 一株高产阿魏酸酯酶的发酵乳杆菌及其应用. CN: CN108823131B, 2020-07-28.

[5] 钟瑾, 倪奎奎, 骆爱群, 苏日娜, 王天威. 一株高产阿魏酸酯酶的约氏乳杆菌及其应用. CN: CN108359624B, 2020-01-21.

[6] 钟瑾, 张杰, 张彤, 芦颖. 一株卷曲乳杆菌及其应用. CN: CN107937324B, 2020-01-21.

[7] 钟瑾, 葛晓璇, 滕坤玲. 一种提高乳酸菌NICE表达系统中nisin诱导效率的方法. CN: CN105950582B, 2019-04-09.

[8] 钟瑾, 张丽, 王宁. 启动子增强系统及其在细菌中的应用. 中国: CN108504656A, 2018-09-07.

[9] 董恩球, 钟瑾, 张敏, 张欣, 王天威, 滕坤玲, 陶勇, 赵煜炜. 一株具益生特性且拮抗产肠毒性大肠杆菌的罗伊氏乳杆菌及应用. 中国: CN108004179A, 2018-05-08.

[10] 钟瑾, 滕坤玲, 王天威, 陶勇, 宫俊杰, 张敏, 赵煜炜. 一种仔猪源解淀粉芽孢杆菌及其应用. 中国: CN107723267A, 2018-02-23.

[11] 钟瑾, 赵方圆. 一种通过糖代谢调控因子提高乳链菌肽nisin产量的方法. 中国: CN104387458A, 2015-03-04.

[12] 钟瑾, 王剑. 一种新型高效的羊毛硫细菌素cerecidin及其应用. 中国: CN103483433A, 2014-01-01.

[13] 钟瑾, 芦颖, 陈美玲, 高涌, 滕坤玲. 一株来源于妇女生殖道产细菌素的益生乳酸菌. 中国: CN102181383A, 2011-09-14.

[14] 钟瑾, 胡红梅, 孙志增, 刘家乐, 还连栋. 能与乳链菌肽结合的突变体蛋白及其编码基因与应用. 中国: CN102002097A, 2011-04-06.

[15] 钟瑾, 路遥, 陈美玲, 还连栋. 乳链菌肽突变体蛋白及其编码基因与应用. 中国: CN101691397A, 2010-04-07.

[16] 钟瑾, 梁小波, 还连栋. 一种纳豆激酶的表达方法及其专用表达载体和工程菌. 中国: CN1900289, 2007-01-24.

出版信息


发表论文
[1] 钟瑾. Nisin Z attenuates lipopolysaccharide-induced mastitis by inhibiting the ERK1/2 3 and p38 MAPK signaling pathways. Journal of Dairy Science[J]. 2022, [2] 钟瑾. Silage fermentation: A Potential microbial approach for the forage utilization of Cyperus esculentus L. by-product.. Fermentation[J]. 2022, [3] 钟瑾. High-throughput discovery of novel lanthipeptides and producers by metagenomic mining of isolates population (MMIP) from Chinese spicy cabbage. Food Research International[J]. 2022, [4] 钟瑾. Characterization of a novel fructosyltransferase InuCA from Lactobacillus crispatus that attaches to the cell surface by electrostatic interaction. Applied and Environmental Microbiology[J]. 2022, [5] Fuqing Huang, Kunling Teng, Yayong Liu, Yanhong Cao, Tianwei Wang, Cui Ma, Jie Zhang, Jin Zhong. Bacteriocins: Potential for Human Health. OXIDATIVE MEDICINE AND CELLULAR LONGEVITYnull. 2021, 2021: http://dx.doi.org/10.1155/2021/5518825.
[6] 钟瑾. 创制现代草产品加工科技体系 保障大粮食安全. 中国科学院院刊[J]. 2021, [7] Liu, Y, Teng, K, Wang, T, Dong, E, Zhang, M, Tao, Y, Zhong, J. Antimicrobial Bacillus velezensis HC6: production of three kinds of lipopeptides and biocontrol potential in maize. JOURNAL OF APPLIED MICROBIOLOGY[J]. 2020, 128(1): 242-254, https://www.webofscience.com/wos/woscc/full-record/WOS:000491851200001.
[8] Wang, Tianwei, Teng, Kunling, Cao, Yanhong, Shi, Weixiong, Xuan, Zeyi, Zhou, Jianhui, Zhang, Jie, Zhong, Jin. Effects of Lactobacillus hilgardii 60TS-2, with or without homofermentative Lactobacillus plantarum B90, on the aerobic stability, fermentation quality and microbial community dynamics in sugarcane top silage. BIORESOURCE TECHNOLOGY[J]. 2020, 312: http://dx.doi.org/10.1016/j.biortech.2020.123600.
[9] 王天威, 曹艳红, 杨果, 钟瑾. 乳酸菌对青贮品质及草食家畜健康的影响. 中国科学:生命科学[J]. 2020, 50(9): 927-938, http://lib.cqvip.com/Qikan/Article/Detail?id=7103155568.
[10] 张彤, 钟瑾. 前导肽切割位点对Ⅱ类羊毛硫细菌素切割酶活性的影响. 微生物学通报[J]. 2019, 46(9): 2198-2206, http://dx.doi.org/10.13344/j.microbiol.china.190120.
[11] Yang, Xiaopan, Teng, Kunling, Su, Rina, Li, Lili, Zhang, Tong, Fan, Keqiang, Zhang, Jie, Zhong, Jin. AcrR and Rex Control Mannitol and Sorbitol Utilization through Their Cross-Regulation of Aldehyde-Alcohol Dehydrogenase (AdhE) in Lactobacillus plantarum. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2019, 85(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000457934800003.
[12] Su, Rina, Ni, Kuikui, Wang, Tianwei, Yang, Xiaopan, Zhang, Jie, Liu, Yayong, Shi, Weixiong, Yan, Liu, Jie, Chen, Zhong, Jin. Effects of ferulic acid esterase-producing Lactobacillus fermentum and cellulase additives on the fermentation quality and microbial community of alfalfa silage. PEERJ[J]. 2019, 7: https://doaj.org/article/06e89ae40fd44836ba39de5e9f4a90a5.
[13] 王天威, 滕坤玲, 刘刚, 刘亚勇, 张欣, 董恩球, 印遇龙, 钟瑾. 微生态制剂对断奶仔猪肠道健康的影响及作用机制. 中国科学:生命科学[J]. 2019, 97-107, http://lib.cqvip.com/Qikan/Article/Detail?id=74678875504849574850484849.
[14] 高树琴, 胡兆民, 韩勇, 刘智全, 潘庆民, 段瑞, 钟瑾, 景海春. 生态草牧业在我国精准扶贫中的作用和潜力——中国科学院植物研究所科技扶贫实践与模式探索. 中国科学院院刊. 2019, 34(2): 223-230+126, http://lib.cqvip.com/Qikan/Article/Detail?id=7001387433.
[15] Wang, Tianwei, Teng, Kunling, Liu, Yayong, Shi, Weixiong, Zhang, Jie, Dong, Enqiu, Zhang, Xin, Tao, Yong, Zhong, Jin. Lactobacillus plantarum PFM 105 Promotes Intestinal Development Through Modulation of Gut Microbiota in Weaning Piglets. FRONTIERS IN MICROBIOLOGY[J]. 2019, 10: https://doaj.org/article/5b5f6bcf4f43405a996ea382205420b6.
[16] Yang, Xiaopan, Teng, Kunling, Li, Lili, Su, Rina, Zhang, Jie, Ai, Guomin, Zhong, Jin. Transcriptional Regulator AcrR Increases Ethanol Tolerance through Regulation of Fatty Acid Synthesis in Lactobacillus plantarum. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2019, 85(22): https://www.webofscience.com/wos/woscc/full-record/WOS:000499128200017.
[17] Qi, Houbao, Li, Yuanyuan, Yun, Huan, Zhang, Tong, Huang, Yugang, Zhou, Jiang, Yan, Hui, Wei, Jianmei, Liu, Yingquan, Zhang, Zhiqian, Gao, Yunhuan, Che, Yongzhe, Su, Xiaomin, Zhu, Dashuai, Zhang, Yuan, Zhong, Jin, Yang, Rongcun. Lactobacillus maintains healthy gut mucosa by producing L-Ornithine. COMMUNICATIONS BIOLOGY[J]. 2019, 2(1): https://doaj.org/article/66b427b27bde4e4394d253a49c092d69.
[18] 钟瑾, 倪奎奎, 杨军香, 玉柱, 陶勇. 我国饲用草产品加工技术的现状及展望. 科学通报[J]. 2018, 63(17): 1677-1685, http://lib.cqvip.com/Qikan/Article/Detail?id=675618511.
[19] 12. 解淀粉芽孢杆菌TF28抗菌脂肽芬芥素的分离鉴定及抑菌作用. 中国生物工程杂志[J]. 2018, 38(10): 20-29, http://lib.cqvip.com/Qikan/Article/Detail?id=676690415.
[20] Ni, Kuikui, Zhao, Jingyun, Zhu, Baoge, Su, Rina, Pan, Yi, Ma, Junkui, Zhou, Guoan, Tao, Yong, Liu, Xiaorong, Zhong, Jin. Assessing the fermentation quality and microbial community of the mixed silage of forage soybean with crop corn or sorghum. BIORESOURCE TECHNOLOGY[J]. 2018, 265: 563-567, http://dx.doi.org/10.1016/j.biortech.2018.05.097.
[21] 钟瑾. 微生态制剂对断奶仔猪肠道健康的影响及作用机理. 中国科学. 2018, [22] Zhang, Li, Teng, Kunling, Wang, Jian, Zhang, Zheng, Zhang, Jie, Sun, Shutao, Li, Lili, Yang, Xiaopan, Zhong, Jin. CerR, a Single-Domain Regulatory Protein of the LuxR Family, Promotes Cerecidin Production and Immunity in Bacillus cereus. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2018, 84(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000425012100014.
[23] 谭华荣, 陶勇, 钟瑾. 我国放线菌和乳链菌肽产生菌遗传学研究的先行者——薛禹谷. 微生物学报. 2018, 58(8): 1505-1506, http://lib.cqvip.com/Qikan/Article/Detail?id=675778072.
[24] 方精云, 景海春, 张文浩, 高树琴, 段子渊, 王竑晟, 钟瑾, 潘庆民, 赵凯, 白文明, 李凌浩, 白永飞, 蒋高明, 黄建辉, 黄振英. 论草牧业的理论体系及其实践. 科学通报[J]. 2018, 63(17): 1619-1631, http://lib.cqvip.com/Qikan/Article/Detail?id=675618506.
[25] Ni, Kuikui, Zhao, Jingyun, Zhu, Baoge, Su, Rina, Pan, Yi, Ma, Junkui, Zhou, Guoan, Tao, Yong, Liu, Xiaorong, Zhong, Jin. Assessing the fermentation quality and microbial community of the mixed silage of forage soybean with crop corn or sorghum. BIORESOURCE TECHNOLOGY[J]. 2018, 265: 563-567, http://dx.doi.org/10.1016/j.biortech.2018.05.097.
[26] Wang, Tianwei, Teng, Kunling, Liu, Gang, Liu, Yayong, Zhang, Jie, Zhang, Xin, Zhang, Min, Tao, Yong, Zhong, Jin. Lactobacillus reuteri HCM2 protects mice against Enterotoxigenic Escherichia coli through modulation of gut microbiota. SCIENTIFIC REPORTS[J]. 2018, 8(1): https://doaj.org/article/f43f1a8325d943ad866c5e19f0c27176.
[27] Ni, Kuikui, Wang, Fangfang, Zhu, Baoge, Yang, Junxiang, Zhou, Guoan, Pan, Yi, Tao, Yong, Zhong, Jin. Effects of lactic acid bacteria and molasses additives on the microbial community and fermentation quality of soybean silage. BIORESOURCE TECHNOLOGY[J]. 2017, 238: 706-715, https://www.webofscience.com/wos/woscc/full-record/WOS:000402485500084.
[28] Xiaopan Yang, Kunling Teng, Jie Zhang, Fangfang Wang, Tong Zhang, Guomin Ai, Peijie Han, Fengyan Bai, Jin Zhong. Transcriptome responses of Lactobacillus acetotolerans F28 to a short and long term ethanol stress. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/5a852f77abfc43fa85bf1d8ca9819dac.
[29] Ge, Xiaoxuan, Teng, Kunling, Wang, Jian, Zhao, Fangyuan, Zhang, Jie, Zhong, Jin. Identification of Key Residues in the NisK Sensor Region for Nisin Biosynthesis Regulation. Frontiers in Microbiology[J]. 2017, 8: https://www.webofscience.com/wos/woscc/full-record/WOS:000392855600001.
[30] Liu, Gang, Chen, Shuai, Zhong, Jin, Teng, Kunling, Yin, Yulong. Crosstalk between Tryptophan Metabolism and Cardiovascular Disease, Mechanisms, and Therapeutic Implications. OXIDATIVE MEDICINE AND CELLULAR LONGEVITYnull. 2017, 2017: https://doaj.org/article/a75bfec5c06045d4ac49f1a365e62ecf.
[31] Liu, Gang, Bin, Peng, Wang, Tianwei, Ren, Wenkai K, Zhong, Jin, Liang, Jun, Hu, ChienAn Andy, Zeng, Zhaoying, Yin, Yulong. DNA Methylation and the Potential Role of Methyl-Containing Nutrients in Cardiovascular Diseases. OXIDATIVE MEDICINE AND CELLULAR LONGEVITYnull. 2017, 2017: https://doaj.org/article/fa7c0b8eabf94395825e60cb3337c43e.
[32] 娄秋莉, 马一鸣, 车雪梅, 钟瑾, 孙小霞, 张浩千. 具有抗菌效应的聚羟基脂肪酸酯生物塑料的制备与功能表征. 生物工程学报[J]. 2016, 32(8): 1052-1059, [33] Ge, Xiaoxuan, Teng, Kunling, Wang, Jian, Zhao, Fangyuan, Wang, Fangfang, Zhang, Jie, Zhong, Jin. Ligand determinants of nisin for its induction activity. JOURNAL OF DAIRY SCIENCE[J]. 2016, 99(7): 5022-5031, http://dx.doi.org/10.3168/jds.2015-10809.
[34] Liang, Weihong, Guan, Guobo, Dai, Yu, Cao, Chengjun, Tao, Li, Du, Han, Nobile, Clarissa J, Zhong, Jin, Huang, Guanghua. Lactic acid bacteria differentially regulate filamentation in two heritable cell types of the human fungal pathogen Candida albicans. MOLECULAR MICROBIOLOGY[J]. 2016, 102(3): 506-519, [35] Guo, Yaoqi, Huang, En, Yang, Xu, Zhang, Liwen, Yousef, Ahmed E, Zhong, Jin. Isolation and characterization of a Bacillus atrophaeus strain and its potential use in food preservation. FOOD CONTROL[J]. 2016, 60: 511-518, https://www.webofscience.com/wos/woscc/full-record/WOS:000364882900069.
[36] Wang, Jian, Ge, Xiaoxuan, Zhang, Li, Teng, Kunling, Zhong, Jin. One-pot synthesis of class II lanthipeptide bovicin HJ50 via an engineered lanthipeptide synthetase. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000389747700001.
[37] Jie Zhang Jin Zhong. The journey of nisin a natural-green food development in China, preservative. 蛋白质与细胞:英文版. 2015, 709-711, http://lib.cqvip.com/Qikan/Article/Detail?id=666483934.
[38] Zhao, Fangyuan, Ma, Hongchu, Lu, Ying, Teng, Kunling, Kang, Xusheng, Wang, Fangfang, Yang, Xiaopan, Zhong, Jin. Complete genome sequence of Lactococcus lactis S0, an efficient producer of nisin. JOURNAL OF BIOTECHNOLOGY[J]. 2015, 198: 15-16, http://dx.doi.org/10.1016/j.jbiotec.2015.01.024.
[39] 张铮, 张丽, 钟瑾, 马宏初, 孙树涛, 钟瑾. 棒状链霉菌中隐性羊毛硫肽CLA 124的半体外生物合成. 微生物学报[J]. 2015, 55(11): 1402-1408, [40] 马宏初, 高涌, 赵方圆, 钟瑾. 羊毛硫细菌素bovicin HJ50修饰酶BovM双功能域单独催化活性鉴定. 微生物学报[J]. 2015, 50-58, [41] Zhang, Jie, Zhong, Jin. The journey of nisin development in China, a natural-green food preservative. PROTEIN & CELLnull. 2015, 6(10): 709-711, https://www.webofscience.com/wos/woscc/full-record/WOS:000362653100002.
[42] 徐婷, 崔占鸿, 钟瑾, 骆爱群, 陶勇, 刘书杰. 青海省部分地区人工种植燕麦青贮乳酸菌的筛选. 江苏农业科学. 2015, 43(2): 205-208, http://lib.cqvip.com/Qikan/Article/Detail?id=663840223.
[43] Ma, Hongchu, Gao, Yong, Zhao, Fangyuan, Wang, Jian, Teng, Kunling, Zhang, Jie, Zhong, Jin. Dissecting the catalytic and substrate binding activity of a class II lanthipeptide synthetase BovM. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2014, 450(2): 1126-1132, https://www.webofscience.com/wos/woscc/full-record/WOS:000339861200034.
[44] Teng Kunling, Zhang Jie, Zhang Xue, Ge Xiaoxuan, Gao Yong, Wang Jian, Lin Yuheng, Zhong Jin. Identification of Ligand Specificity Determinants in Lantibiotic Bovicin HJ50 and the Receptor BovK, a Multitransmembrane Histidine Kinase *. The Journal of Biological Chemistry[J]. 2014, 289(14): 9823-9832, http://dx.doi.org/10.1074/jbc.M113.513150.
[45] Li Tao, Han Du, Guobo Guan, Yu Dai, Clarissa J Nobile, Weihong Liang, Chengjun Cao, Qiuyu Zhang, Jin Zhong, Guanghua Huang. Discovery of a "White-Gray-Opaque'' Tristable Phenotypic Switching System in Candida albicans: Roles of Non-genetic Diversity in Host Adaptation. PLOS BIOLOGY[J]. 2014, 12(4): http://dx.doi.org/10.1371/journal.pbio.1001830.
[46] 钟瑾. 乳链菌肽—从实验室走进百姓生活. 微生物学通报. 2014, [47] Wang, Jian, Gao, Yong, Teng, Kunling, Zhang, Jie, Sun, Shutao, Zhong, Jin. Restoration of Bioactive Lantibiotic Suicin from a Remnant lan Locus of Pathogenic Streptococcus suis Serotype 2. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2014, 80(3): 1062-1071, https://www.webofscience.com/wos/woscc/full-record/WOS:000329848900029.
[48] Wang, Jian, Ma, Hongchu, Ge, Xiaoxuan, Zhang, Jie, Teng, Kunling, Sun, Zhizeng, Zhong, Jin. Bovicin HJ50-Like Lantibiotics, a Novel Subgroup of Lantibiotics Featured by an Indispensable Disulfide Bridge. PLOS ONE[J]. 2014, 9(5): https://doaj.org/article/3d29bd4e230243e09af9a1d5f264ab44.
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