1、心肌肥厚和心力衰竭。是本实验室一直倾心关注的课题，主要从动物和细胞两方面开展研究，模型稳定可靠，技术路线成熟。

2、代谢性疾病的发病机制。实验室近几年在这方面取得了一些进展，动物模型成熟，有很多有趣的地方等待你去发掘

3、自由基生物学，实验室的立身根本，关注生物体内自由基的检测、分析和信号通路

欢迎具有生物信息学、生物化学与分子生物学、细胞生物学、生理学、医学、遗传学等背景的本科生报考!
欢迎有意报考的同学通过邮件、电话提前联系，来访和实习。

2022年招收1名硕士生，优先考虑推荐免试生，欢迎及时报名！

​

071009-细胞生物学
071011-生物物理学

自由基生物学
心脏病学

2003-09--2006-09   中国科学院生物物理研究所   理学博士
2000-09--2003-07   四川大学   工学硕士
1996-09--2000-07   四川大学   工学学士

研究生

博士

2006年9月-2009年8月， 美国明尼苏达大学医学院，博士后
2009年8月-2012年1月， 美国明尼苏达大学医学院，研究助理
2012年2月——， 中国科学院大学生命科学学院，教授，博士生导师

美国心脏协会会员，国际神经化学学会会员、国际自由基生物学与医学学会会员，中国生物物理学会自由基专业委员会理事
2007起担任Hypertension、Cancer Science、Toxicology and Industrial Health和生物化学与生物物理进展等杂志的审稿人

2012-02~现在, 中国科学院大学, 教授
2009-08~2012-01,美国明尼苏达大学医学院, Research Associate
2006-09~2009-08,美国明尼苏达大学医学院, 博士后

工程伦理（春）-生物1班
细胞氧化还原生物学
工程伦理（春）-生物2班
工程伦理-生物（1班）
干细胞生物学
生物活性小分子
工程伦理-生物（2班）
工程伦理-生物
工程伦理
工程伦理-资环
工程伦理-机械
工程伦理-化学
工程伦理通论
工程伦理-信息
工程伦理-材料
工程伦理-核能
工程伦理-生物（春）
组织工程学
生物医学系列讲座
干细胞生物学前沿问题讨论班
微生物学实验技术
文献阅读课

   

[1] Juntao Yuan, Zhuoran Yu, Junling Gao, Kai Luo, Xiyue Shen, Bingqing Cui, Zhongbing Lu. Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation. Redox Biology. 2022, 49: [2] Li, Tianhe, Zhang, Tingting, Gao, Huimin, Liu, Ruixia, Gu, Muqing, Yang, Yuxi, Cui, Tianyu, Lu, Zhongbing, Yin, Chenghong. Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction. REDOX BIOLOGY[J]. 2021, 41: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896192/.
[3] Chen, Xiaoyu, Guo, Jing, Huang, Yunlong, Liu, Shan, Huang, Ying, Zhang, Zezhong, Zhang, Fang, Lu, Zhongbing, Li, Fang, Zheng, Jialin C, Ding, Wenjun. Urban airborne PM2.5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb. ENVIRONMENTAL POLLUTION[J]. 2020, 264: http://dx.doi.org/10.1016/j.envpol.2020.114716.
[4] Gao, Junling, Yuan, Juntao, Wang, Qiaoe, Lei, Tong, Shen, Xiyue, Cui, Bingqing, Zhang, Fang, Ding, Wenjun, Lu, Zhongbing. Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase alpha 2. REDOX BIOLOGY[J]. 2020, 28: https://www.webofscience.com/wos/woscc/full-record/WOS:000501490700050.
[5] Guo, Haipeng, Xu, Dachun, Kuroki, Marcos, Lu, Zhongbing, Xu, Xin, Geurts, Aron, Osborn, John W, Chen, Yingjie. Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2020, 152: 787-796, http://dx.doi.org/10.1016/j.freeradbiomed.2020.01.023.
[6] Junling Gao, Juntao Yuan, Qiaoe Wang, Tong Lei, Xiyue Shen, Bingqing Cui, Fang Zhang, Wenjun Ding, Zhongbing Lu. Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase α2. Redox Biology. 2020, 28: http://dx.doi.org/10.1016/j.redox.2019.101345.
[7] Yue, Wenhui, Tong, Lei, Liu, Xiaohong, Weng, Xinyu, Chen, Xiaoyu, Wang, Dongzhi, Dudley, Samuel C, Weir, E Kenneth, Ding, Wenjun, Lu, Zhongbing, Xu, Yawei, Chen, Yingjie. Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy. REDOX BIOLOGY[J]. 2019, 22: 101161-, http://dx.doi.org/10.1016/j.redox.2019.101161.
[8] Wang, Hongyun, Shen, Xiyue, Liu, Jingli, Wu, Chunyan, Gao, Junling, Zhang, Zezhong, Zhang, Fang, Ding, Wenjun, Lu, Zhongbing. The effect of exposure time and concentration of airborne PM2.5 on lung injury in mice: A transcriptome analysis. REDOX BIOLOGY[J]. 2019, 26: 101264-, http://dx.doi.org/10.1016/j.redox.2019.101264.
[9] Feng, Wei, Lei, Tong, Wang, Yue, Feng, Run, Yuan, Juntao, Shen, Xiyue, Wu, Yongguang, Gao, Junling, Ding, Wenjun, Lu, Zhongbing. GCN2 deficiency ameliorates cardiac dysfunction in diabetic mice by reducing lipotoxicity and oxidative stress. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2019, 130: 128-139, http://dx.doi.org/10.1016/j.freeradbiomed.2018.10.445.
[10] Wang, Peng, Xu, Yana, Zhang, Jiayu, Shi, Lu, Lei, Tong, Hou, Yangxiao, Lu, Zhongbing, Zhao, Yong. The amino acid sensor general control nonderepressible 2 (GCN2) controls T(H)9 cells and allergic airway inflammation. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY[J]. 2019, 144(4): 1091-1105, http://dx.doi.org/10.1016/j.jaci.2019.04.028.
[11] Tian, Guoxiong, Wang, Juan, Lu, Zhongbing, Wang, Hongyun, Zhang, Wei, Ding, Wenjun, Zhang, Fang. Indirect effect of PM1 on endothelial cells via inducing the release of respiratory inflammatory cytokines. TOXICOLOGY IN VITRO[J]. 2019, 57: 203-210, http://dx.doi.org/10.1016/j.tiv.2019.03.013.
[12] Hongyun Wang, Xiyue Shen, Guoxiong Tian, Xili Shi, Wei Huang, Yongguang Wu, Lei Sun, Can Peng, Shasha Liu, Ying Huang, Xiaoyu Chen, Fang Zhang, Yingjie Chen, Wenjun Ding, Zhongbing Lu. AMPKα2 deficiency exacerbates long-term PM2.5 exposure-induced lung injury and cardiac dysfunction. Free Radical Biology and Medicine. 2018, 121: 202-214, http://dx.doi.org/10.1016/j.freeradbiomed.2018.05.008.
[13] Wang, Yue, Lei, Tong, Yuan, Juntao, Wu, Yongguang, Shen, Xiyue, Gao, Junling, Feng, Wei, Lu, Zhongbing. GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress. REDOX BIOLOGY[J]. 2018, 17: 25-34, http://dx.doi.org/10.1016/j.redox.2018.04.009.
[14] Ting Wang, Beibei Mao, Chi Cheng, Zhuangzhi Zou, Junling Gao, Yanglu Yang, Tong Lei, Xiaolong Qi, Zengqiang Yuan, Wentong Xu, Zhongbing Lu. YAP promotes breast cancer metastasis by repressing growth differentiation factor-15. BBA - Molecular Basis of Disease. 2018, 1864(5): 1744-1753, http://dx.doi.org/10.1016/j.bbadis.2018.02.020.
[15] Guo, Yuting, Wang, Huiwen, Tang, Yinglong, Wang, Yue, Zhang, Mengqi, Yang, Zhiguang, Nyirimigabo, Eric, Wei, Bin, Lu, Zhongbing, Ji, Guangju. GCN2 deficiency protects mice from denervation-induced skeletal muscle atrophy via inhibiting FoxO3a nuclear translocation. PROTEIN & CELLnull. 2018, 9(11): 966-970, http://lib.cqvip.com/Qikan/Article/Detail?id=676820274.
[16] Liu, Shasha, Yuan, Juntao, Yue, Wenhui, Bi, Yanwei, Shen, Xiyue, Gao, Junling, Xu, Xin, Lu, Zhongbing. GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE[J]. 2018, 1864(10): 3257-3267, http://www.corc.org.cn/handle/1471x/2172619.
[17] Shasha Liu, Juntao Yuan, Wenhui Yue, Yanwei Bi, Xiyue Shen, Junling Gao, Xin Xu, Zhongbing Lu. GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice. BBA - Molecular Basis of Disease. 2018, 1864(10): 3257-3267, http://dx.doi.org/10.1016/j.bbadis.2018.07.012.
[18] Wang, Hongyun, Shen, Xiyue, Tian, Guoxiong, Shi, Xili, Huang, Wei, Wu, Yongguang, Sun, Lei, Peng, Can, Liu, Shasha, Huang, Ying, Chen, Xiaoyu, Zhang, Fang, Chen, Yingjie, Ding, Wenjun, Lu, Zhongbing. AMPK alpha 2 deficiency exacerbates long-term PM2.5 exposure-induced lung injury and cardiac dysfunction. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2018, 121: 202-214, https://www.webofscience.com/wos/woscc/full-record/WOS:000433208200021.
[19] Chen, Xiaoyu, Liu, Shan, Zhang, Wei, Wu, Chunyan, Liu, Hanchen, Zhang, Fang, Lu, Zhongbing, Ding, Wenjun. Nrf2 deficiency exacerbates PM2.5-induced olfactory bulb injury. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2018, 505(4): 1154-1160, http://dx.doi.org/10.1016/j.bbrc.2018.10.057.
[20] Wang, Ting, Mao, Beibei, Cheng, Chi, Zou, Zhuangzhi, Gao, Junling, Yang, Yanglu, Lei, Tong, Qi, Xiaolong, Yuan, Zengqiang, Xu, Wentong, Lu, Zhongbing. YAP promotes breast cancer metastasis by repressing growth differentiation factor-15. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE[J]. 2018, 1864(5): 1744-1753, http://dx.doi.org/10.1016/j.bbadis.2018.02.020.
[21] Xu, Jinxia, Zhang, Wei, Lu, Zhongbing, Zhang, Fang, Ding, Wenjun. Airborne PM2.5-Induced Hepatic Insulin Resistance by Nrf2/JNK-Mediated Signaling Pathway. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH[J]. 2017, 14(7): https://doaj.org/article/8cfb36d525fb4313a75912b34d4ebae4.
[22] Shi, Linlin, Zhao, Chenyang, Wang, Hongyun, Lei, Tong, Liu, Shasha, Cao, Jianwei, Lu, Zhongbing. Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice. ANTIOXIDANTS & REDOX SIGNALING[J]. 2017, 27(16): 1347-1360, https://www.webofscience.com/wos/woscc/full-record/WOS:000413276200006.
[23] Li, Tianhe, Feng, Run, Zhao, Chenyang, Wang, Yue, Wang, Jian, Liu, Shasha, Cao, Jianwei, Wang, Hongyun, Wang, Ting, Guo, Yuting, Lu, Zhongbing. Dimethylarginine Dimethylaminohydrolase 1 Protects Against High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice. ANTIOXIDANTS & REDOX SIGNALING[J]. 2017, 26(11): 599-611, https://www.webofscience.com/wos/woscc/full-record/WOS:000398467900003.
[24] Guo, Yuting, Jin, Meng, Tang, Yinglong, Wang, Ting, Wei, Bin, Feng, Run, Gong, Bing, Wang, Huiwen, Ji, Guangju, Lu, Zhongbing. AMP-activated kinase alpha 2 deficiency protects mice from denervation-induced skeletal muscle atrophy. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS[J]. 2016, 600: 56-60, https://www.webofscience.com/wos/woscc/full-record/WOS:000376812600006.
[25] Hongyun Wang, Yuting Guo, Limin Liu, Longfei Guan, Ting Wang, Luyao Zhang, Yue Wang, Jianwei Cao, Wenjun Ding, Fang Zhang, Zhongbing Lu. DDAH1 plays dual roles in PM2.5 induced cell death in A549 cells. BBA - General Subjects. 2016, 1860(12): 2793-2801, http://dx.doi.org/10.1016/j.bbagen.2016.03.022.
[26] 冯润, 王红云, 赵保路, 陆忠兵. 基于一氧化氮和天然抗氧化剂的新配方的心肌保护作用. 中国科学院大学学报[J]. 2016, 33(5): 625-631, [27] Wang, Hongyun, Guo, Yuting, Liu, Limin, Guan, Longfei, Wang, Ting, Zhang, Luyao, Wang, Yue, Cao, Jianwei, Ding, Wenjun, Zhang, Fang, Lu, Zhongbing. DDAH1 plays dual roles in PM2.5 induced cell death in A549 cells. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS[J]. 2016, 1860(12): 2793-2801, http://dx.doi.org/10.1016/j.bbagen.2016.03.022.
[28] Zhao, Chenyang, Li, Tianhe, Han, Bingxing, Yue, Wenhui, Shi, Linlin, Wang, Hongyun, Guo, Yuting, Lu, Zhongbing. DDAH1 deficiency promotes intracellular oxidative stress and cell apoptosis via a miR-21-dependent pathway in mouse embryonic fibroblasts. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2016, 92: 50-60, http://dx.doi.org/10.1016/j.freeradbiomed.2016.01.015.
[29] Xing, Yingying, Chu, Qiaoyun, Feng, Run, Wang, Wei, Liu, Lixin, Lu, Zhongbing. hCLP46 increases Smad3 protein stability via inhibiting its ubiquitin-proteasomal degradation. PROTEIN & CELLnull. 2015, 6(10): 767-770, http://lib.cqvip.com/Qikan/Article/Detail?id=666483940.
[30] Quan, Xin, Yue, Wenhui, Luo, Yunfeng, Cao, Jianwei, Wang, Hongyun, Wang, Yue, Lu, Zhongbing. The protein arginine methyltransferase PRMT5 regulates A-induced toxicity in human cells and Caenorhabditis elegans models of Alzheimer's disease. JOURNAL OF NEUROCHEMISTRY[J]. 2015, 134(5): 969-977, https://www.webofscience.com/wos/woscc/full-record/WOS:000359383500016.
[31] Luo, Yunfeng, Yue, Wenhui, Quan, Xin, Wang, Yue, Zhao, Baolu, Lu, Zhongbing. Asymmetric dimethylarginine exacerbates A beta-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2015, 79: 117-126, https://www.webofscience.com/wos/woscc/full-record/WOS:000350392900010.
[32] Xing, Yingying, Chu, Qiaoyun, Feng, Run, Wang, Wei, Liu, Lixin, Lu, Zhongbing. hCLP46 increases Smad3 protein stability via inhibiting its ubiquitin-proteasomal degradation (vol 6, pg 767, 2015). PROTEIN & CELLnull. 2015, 6(12): 929-929, https://www.webofscience.com/wos/woscc/full-record/WOS:000365514600012.
[33] Wang, Yue, Zhang, Ping, Xu, Zhiyu, Yue, Wenhui, Zhuang, Yan, Chen, Yingjie, Lu, Zhongbing. S-nitrosylation of PDE5 increases its ubiquitin-proteasomal degradation. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2015, 86: 343-351, http://dx.doi.org/10.1016/j.freeradbiomed.2015.05.037.
[34] Liu, Xiaoyu, Kwak, Dongmin, Lu, Zhongbing, Xu, Xin, Fassett, John, Wang, Huan, Wei, Yidong, Cavener, Douglas R, Hu, Xinli, Hall, Jennifer, Bache, Robert J, Chen, Yingjie. Endoplasmic Reticulum Stress Sensor Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Protects Against Pressure Overload-Induced Heart Failure and Lung Remodeling. HYPERTENSION[J]. 2014, 64(4): 738-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000341988000011.
[35] Lu, Zhongbing, Xu, Xin, Fassett, John, Kwak, Dongmin, Liu, Xiaoyu, Hu, Xinli, Wang, Huan, Guo, Haipeng, Xu, Dachun, Yan, Shuo, McFalls, Edward O, Lu, Fei, Bache, Robert J, Chen, Yingjie. Loss of the Eukaryotic Initiation Factor 2 alpha Kinase General Control Nonderepressible 2 Protects Mice From Pressure Overload-Induced Congestive Heart Failure Without Affecting Ventricular Hypertrophy. HYPERTENSION[J]. 2014, 63(1): 128-135, https://www.webofscience.com/wos/woscc/full-record/WOS:000328206800026.
[36] Xu, Xin, Lu, Zhongbing, Fassett, John, Zhang, Ping, Hu, Xinli, Liu, Xiaoyu, Kwak, Dongmin, Li, Jingxin, Zhu, Guangshuo, Tao, Yi, Hou, Mingxiao, Wang, Huan, Guo, Haipeng, Viollet, Benoit, McFalls, Edward O, Bache, Robert J, Chen, Yingjie. Metformin Protects Against Systolic Overload-Induced Heart Failure Independent of AMP-Activated Protein Kinase a2. HYPERTENSION[J]. 2014, 63(4): 723-728, https://www.webofscience.com/wos/woscc/full-record/WOS:000332685500030.
[37] Shi, Zhenhua, Lu, Zhongbing, Zhao, Yashuo, Wang, Yueqi, Xi ZhaoWilson, Guan, Peng, Duan, Xianglin, Chang, YanZhong, Zhao, Baolu. Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model. NEUROCHEMISTRY INTERNATIONAL[J]. 2013, 62(7): 940-947, http://dx.doi.org/10.1016/j.neuint.2013.03.001.
[38] Lu, Zhongbing, Hu, Xinli, Huang, Yimin, Xu, Xin, Zhang, Ping, Peterson, Mark, Polunovsky, Vitaly A, Sonenberg, Nahum, Bache, Robert J, Bitterman, Peter B, Chen, Yingjie. Deletion Of The Translational Repressors Eukaryotic Translation Initiation Factor 4e Binding Proteins 1 And 2 Protects Against Pressure Overload Induced Heart Failure. CIRCULATION RESEARCHnull. 2013, 113(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000332063200313.

   

（ 1 ）  ****启动, 主持, 部委级, 2012-05--2013-03
（ 2 ） GCN2影响心肌肥厚和心力衰竭的分子机制研究, 主持, 国家级, 2013-01--2016-12
（ 3 ） BR计划, 主持, 部委级, 2013-01--2015-12
（ 4 ） 4E-BP1调控翻译起始影响心肌肥厚和心力衰竭的分子机制研究, 主持, 国家级, 2015-01--2018-12
（ 5 ） 大气细颗粒物毒性组分在呼吸道的定位分布及其引发呼吸道损伤及保护/适应性反应的分子作用机制, 参与, 国家级, 2017-01--2020-12
（ 6 ） 大气细颗粒物暴露引发心肌功能失常的作用和分子机制, 主持, 国家级, 2018-01--2020-12
（ 7 ） 优秀青年教师科研能力提升项目, 主持, 市地级, 2019-01--2019-12
（ 8 ） 一氧化氮产品功能验证, 主持, 院级, 2019-01--2020-12
（ 9 ） GCN2抑制剂对糖尿病心肌病的保护作用及机制研究, 主持, 国家级, 2021-01--2024-12
（ 10 ） 兴奋剂检测关键技术平台研究, 参与, 国家级, 2020-10--2022-12

我们和美国明尼苏达大学医学院陈英杰教授、北京大学分子医学研究所胡新立教授等研究组建立了良好的合作关系。

已指导学生

岳文慧  博士研究生  071009-细胞生物学  

全欣  硕士研究生  085238-生物工程  

郭玉婷  硕士研究生  085238-生物工程  

赵晨阳  博士研究生  071009-细胞生物学  

李天鹤  博士研究生  071009-细胞生物学  

邢莹莹  硕士研究生  071005-微生物学  

张士伟  硕士研究生  085238-生物工程  

杨金龙  硕士研究生  085238-生物工程  

石琳琳  硕士研究生  071009-细胞生物学  

冯润  硕士研究生  085238-生物工程  

王婷  硕士研究生  071009-细胞生物学  

曹建伟  硕士研究生  085238-生物工程  

王月  博士研究生  071009-细胞生物学  

刘莎莎  硕士研究生  071009-细胞生物学  

王红云  博士研究生  071009-细胞生物学  

吴永光  硕士研究生  085238-生物工程  

冯玮  博士研究生  071009-细胞生物学  

袁军涛  博士研究生  071009-细胞生物学  

雷桐  博士研究生  071009-细胞生物学  

现指导学生

沈曦月  博士研究生  071009-细胞生物学  

高俊灵  博士研究生  071009-细胞生物学  

骆开  硕士研究生  086000-生物与医药  

崔冰清  博士研究生  071009-细胞生物学  

蓝婷  硕士研究生  071009-细胞生物学  

张瑜净  硕士研究生  086000-生物与医药  

于卓然  博士研究生  071009-细胞生物学  

徐颖  博士研究生  071009-细胞生物学