基本信息

张维绮  Zhang Weiqi

博导  研究员 


​zhangwq@big.ac.cn

中国科学院北京基因组研究所(国家生物信息中心)

通信地址: 北京市朝阳区北辰西路1号院104号楼

邮政编码: 100101

招生信息

招生专业:基因组学、生物信息学、细胞生物学

招生方向:衰老的表观基因组学,再生的表观基因组学

学习经历

20019-20056月,南昌大学,生物工程专业,理学学士学位

20059-20116月,北京大学,细胞生物学专业,理学博士学位

工作经历

20192月至今,中国科学院北京基因组所,研究员,博士生导师

201612-20191月,中国科学院生物物理研究所,研究员

201510-201612月,中国科学院生物物理研究所,副研究员

201110-201510月,中国科学院生物物理研究所,助理研究员

学术兼职

中国生物物理学会衰老生物学分会秘书长

中国细胞生物学会干细胞生物学分会理事

中国细胞生物学会衰老细胞生物学分会委员

获奖及荣誉

2021 中华医学科技奖主要完成人之一

2020 中国科学十大进展主要完成人之一

2020 中国生命科学十大进展主要完成人之一

2020 中国科学院杰出科技成就奖主要完成人之一

2018 中国生命科学十大进展主要完成人之一

2018 国家优秀青年基金

研究方向

1.衰老机制:从表观、免疫和代谢等方面研究系统衰老机制

2.衰老预警:建立 Aging index,衡量器官和个体衰老的程度

​3.衰老干预:人干细胞衰老模拟、干预策略评估及转化应用 

课题组聚焦衰老及其相关疾病的机制和干预研究,长期围绕衰老的关键科学问题开展基础和转化研究,致力于回答我们究竟有多老,我们为什么会衰老,如何让我们老的慢一些。目前主要集中于三大研究方向:整合多层次组学和单细胞图谱等多维度生命组学数据,从系统生物学角度深入挖掘衰老及其干预的核心机制,特别是衰老的表观遗传、免疫和代谢机制;通过大数据分析系统揭示器官和个体衰老的生物标志物,进而依托跨年龄人群队列,基于人工智能计算建立衡量生物学年龄的指标体系,建立增龄相关疾病风险预警方案,评估环境压力以及主动健康干预等因素对于衰老的影响;通过功能基因组学筛选,系统揭示衰老的可干预靶标,并综合利用化学生物学、基因编辑和数字建模等方法探索延缓衰老的新策略,积极推动其临床转化应用。

https://doi.org/10.1016/j.stem.2021.04.020


代表性论文

  1. Shuai Ma#, Si Wang#, Yanxia Ye#, Jie Ren#, Ruiqing Chen#, Wei Li, Jiaming Li, Liyun Zhao, Qian Zhao, Guoqiang Sun, Ying Jing, Yuesheng Zuo, Muzhao Xiong, Yuanhan Yang, Qiaoran Wang, Jinghui Lei, Shuhui Sun, Xiao Long, Moshi Song, Shuyang Yu, Piu Chan, Jianwei Wang, Qi Zhou, Juan Carlos Izpisua Belmonte, Jing Qu*, Weiqi Zhang*, Guang-Hui Liu*. (2022). Heterochronic Parabiosis Induces Stem Cell Revitalization and Systemic Rejuvenation Across Aged Tissues. Cell Stem Cell S1934-5909(22)00170-9.

  2. Zunpeng Liu#, Qianzhao Ji#, Jie Ren#, Pengze Yan#, Zeming Wu#, Si Wang, Liang Sun, Zehua Wang, Jiaming Li, Guoqiang Sun, Chuqian Liang, Run Sun, Xiaoyu Jiang, Jianli Hu, Yingjie Ding, Qiaoran Wang, Shijia Bi, Gang Wei, Gang Cao, Guoguang Zhao, Hongmei Wang, Qi Zhou, Juan Carlos Izpisua Belmonte, Jing Qu*, Weiqi Zhang*, Guang-Hui Liu*. (2022). Large-Scale Chromatin Reorganization Reactivates Placenta-Specific Genes that Drive Cellular Aging. Developmental Cell S1534-5807(22)00332-X.

  3. Sheng Zhang#, Zeming Wu#, Yue Shi#, Si Wang#, Jie Ren#, Zihui Yu, Daoyuan Huang, Kaowen Yan, Yifang He, Xiaoqian Liu, Qianzhao Ji, Beibei Liu, Zunpeng Liu, Jing Qu, Guang-Hui Liu*, Weimin Ci*, Xiaoqun Wang*, Weiqi Zhang*. (2022). FTO Stabilizes MIS12 and Counteracts Senescence. Protein & Cell doi: 10.1007/s13238-022-00914-6.

  4. Wei Li#, Zhiran Zou#, Yusheng Cai#, Kuan Yang#, Si Wang#, Zunpeng Liu, Lingling Geng, Qun Chu, Zhejun Ji, Piu Chan, Guang-Hui Liu*, Moshi Song*, Jing Qu*, Weiqi Zhang*. (2022). Low-Dose Chloroquine Treatment Externds the Lifespan of Aged Rats. Protein & Cell 13(6):454-461.

  5. Si Wang#, Fang Cheng#, Qianzhao Ji#, Moshi Song#, Zeming Wu, Yiyuan Zhang, Zhejun Ji, Huyi Feng, Juan Carlos Izpisua Belmonte, Qi Zhou, Jing Qu*, Wei Li*, Guang-Hui Liu*, Weiqi Zhang*. (2021). Hyperthermia Differentially Affects Specific Human Stem Cells and Their Differentiated Derivatives. Protein & Cell doi: 10.1007/s13238-021-00887-y.

  6. Weiqi Zhang. (2021). The Quest to Understand Aging during and after COVID-19. Cell Stem Cell 28(5):805-807.

  7. Aging Atlas Consortium. (2021). Aging Atlas: A Multi-Omics Database for Aging Biology. Nucleic Acids Research 49(D1): D825-D830. (Co-corresponding author)

  8. Wei Wang#, Yuxuan Zheng#, Shuhui Sun#, Wei Li#, Moshi Song, Qianzhao Ji, Zeming Wu, Zunpeng Liu, Yanling Fan, Feifei Liu, Jingyi Li, Concepcion Rodriguez Esteban, Si Wang, Qi Zhou, Juan Carlos Izpisua Belmonte, Weiqi Zhang*, Jing Qu*, Fuchou Tang* and Guang-Hui Liu*. (2021). A Genome-wide CRISPR-Based Screen Identifies KAT7 as a Senescence Driver. Science Translational Medicine 13(575): eabd2655. (Interviewed by Ruters news and Beijing TV; Reported by FOX news, CBS, U.S. News & World Report)

  9. Zhiran Zou #, Xiao Long#, Qian Zhao #, Yandong Zheng#, Moshi Song#, Shuai Ma#, Yaobin Jing, Si Wang, Yifang He, Concepcion Rodriguez Esteban, Nanze Yu, Jiuzuo Huang, Piu Chan, Ting Chen, Juan Carlos Izpisua Belmonte, Weiqi Zhang*, Jing Qu* and Guang-Hui Liu*. (2021). A Single-Cell Transcriptomic Atlas of Human Skin Aging. Developmental Cell 56(3): 383-397.e388. (Cover story; Highlighted by Developmental Cell)

  10. Shuai Ma#, Shuhui Sun#, Lingling Geng#, Moshi Song#, Wei Wang, Yanxia Ye, Qianzhao Ji, Zhiran Zou, Si Wang, Xiaojuan He, Wei Li, Concepcion Rodriguez Esteban, Xiao Long, Guoji Guo, Piu Chan, Qi Zhou, Juan Carlos Izpisua Belmonte*, Weiqi Zhang*, Jing Qu* and Guang-Hui Liu*. (2020a). Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell 180(5):984-1001.e22. (Highlighted by Nature; Highlighted by Science Translational Medicine)

  11. Si Wang#, Yuxuan Zheng#, Jingyi Li#, Yang Yu#, Weiqi Zhang#, Moshi Song, Zunpeng Liu, Zheying Min, Huifang Hu, Ying Jing, Xiaojuan He, Liang Sun, Lifang Ma, Concepcion Rodriguez Esteban, Piu Chan, Jie Qiao, Qi Zhou, Juan Carlos Izpisua Belmonte*, Jing Qu*, Fuchou Tang* and Guang-Hui Liu*. (2020b). Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell 180(3): 585-600.e519. (Cover story; Recommended by F1000)

  12. Weiqi Zhang, Jing Qu, Guang-Hui Liu* and Juan Carlos Izpisua Belmonte*. (2020). The Ageing Epigenome and Its rejuvenation. Nature Reviews Molecular Cell Biology 21(3): 137-150. (First author)

  13. Shuai Ma #, Shuhui Sun #, Jiaming Li #, Yanling Fan #, Jing Qu #, Liang Sun #, Si Wang, Yiyuan Zhang, Shanshan Yang, Zunpeng Liu, Zeming Wu, Sheng Zhang, Qiaoran Wang, Aihua Zheng, Shuguang Duo, Yang Yu, Juan Carlos Izpisua Belmonte, Piu Chan, Qi Zhou, Moshi Song*, Weiqi Zhang* and Guang-Hui Liu*. (2020). Single-Cell Transcriptomic Atlas of Primate Cardiopulmonary Aging. Cell Research 31(4): 415-432. (*Co-corresponding author)

  14. Weiqi Zhang#, Shu Zhang#, Pengze Yan#, Jie Ren#, Moshi Song, Jingyi Li, Jinghui Lei, Huize Pan, Si Wang, Xibo Ma, Shuai Ma, Hongyu Li, Fei Sun, Haifeng Wan, Wei Li, Piu Chan, Qi Zhou, Guang-Hui Liu*,Fuchou Tang* and Jing Qu*. (2020).A single-cell transcriptomic landscape of primate arterial aging. Nature Communications 11(1): 2202. (#Co-first author)

  15. Weiqi Zhang#, Haifeng Wan#, Guihai Feng#, Jing Qu#, Jiaqiang Wang, Yaobin Jing, Ruotong Ren, Zunpeng Liu, Linlin Zhang, Zhiguo Chen, Shuyan Wang, Yong Zhao, Zhaoxia Wang, Yun Yuan, Qi Zhou, Wei Li*, Guang-Hui Liu* and Baoyang Hu*. (2018). Sirt6 Deficiency Results in Developmental Retardation in Cynomolgus Monkeys. Nature 560(7720): 661-665. (Highlighted by Nature; Highlighted by China Daily, CCTV)

  16. Nard Kubben, Weiqi Zhang (Co-senior author), Lixia Wang, Ty C. Voss, Jiping Yang, Jing Qu#, Guang-Hui Liu* and Tom Misteli*. (2016). Repression of the Antioxidant Nrf2 Pathway in Premature Aging. Cell 165(6): 1361-1374. (Highlighted by Cell; Recommended by F1000)

  17. Weiqi Zhang#, Jingyi Li#, Keiichiro Suzuki#, Jing Qu#, Ping Wang, Junzhi Zhou, Xiaomeng Liu, Ruotong Ren, Xiuling Xu, Alejandro Ocampo, Tingting Yuan, Jiping Yang, Ying Li, Liang Shi, Dee Guan, Huize Pan, Shunlei Duan, Zhichao Ding, Mo Li, Fei Yi, Ruijun Bai, Yayu Wang, Chang Chen, Fuquan Yang, Xiaoyu Li, Zimei Wang, Emi Aizawa, April Goebl, Rupa Devi Soligalla, Pradeep Reddy, Concepcion Rodriguez Esteban, Fuchou Tang*, Guang-Hui Liu* and Juan Carlos Izpisua Belmonte*. (2015). A Werner Syndrome Stem Cell Model Unveils Heterochromatin Alterations as a Driver of Human Aging. Science 348(6239): 1160-1163. (Highlighted by Science; Highlighted by Nature Reviews Genetics; Highlighted by TIME, Washington Post, Science News, CCTV)

项目组简介

干细胞是机体组织器官再生的源泉,其自我更新与分化之间的动态平衡对于组织器官的生长发育和机能维持具有重要的作用。在人类的一生中,干细胞经历了蓬勃发育、维持和衰退的过程。这一过程受到严格的时空调控,而干细胞命运调控机制的失衡与人类疾病的发生息息相关。在衰老过程中,干细胞逐渐耗竭,是导致衰老和衰老相关疾病的发生的重要原因。

课题组主要围绕干细胞的命运决定和稳态维持,通过结合基因编辑技术、多谱系的干细胞分化技术、多层次组学手段、新型的动物模型等,系统研究再生与衰老的分子机制,特别是表观遗传因素在机体退化和病变中发生的作用。取得的主要研究成果包括:(1)围绕衰老机制和干预,揭示表观基因组失序驱动人类干细胞衰老(Science 2015, Cell 2016);(2)首次利用基因编辑产生长寿基因敲除猴模型(Nature 2018);(3)系统解析灵长类重要器官衰老的分子标记物和调控靶标(Cell 2020b 封面文章, Developmental Cell 2021封面文章, Nature Communications 2020, Cell Research 2020, 并阐明热量限制通过调节机体免疫炎症通路延缓衰老的新机制(Cell 2020a);(4)开创人类干细胞衰老研究体系,筛选获得延缓衰老的小分子和基因靶标(Cell 2016Science Translational Medicine 2021);(5)建立首个衰老多组学数据库Aging AtlasNucleic Acids Research 2021)。

项目组成员:

工作人员:范艳玲 助理研究员,陈静 助理工程师,刘蓓蓓 特别研究助理

研究生:胡健立 2019,王翠 2019,李豪 2019,丁英杰 2019,王俏然 2019,刘黎啸 2020,熊沐钊 2020,李嘉明 2020,孙晓燕 2020,平佳乐 2020

已毕业研究生:康望 2018



项目组研究成果

2020年中国科学十大进展

 

深度解析多器官衰老的标记物和干预靶标

In depth dissection of new biomarkers and therapeutic targets of mulf-organ aging

 

深入研究衰老、科学应对人口老龄化是新时代的国家重大需求。合作团队围绕衰老的机制和干预等核心科学问题,利用多学科交叉的方法,在系统水平上揭示了哺乳动物多器官衰老的新型生物学标记物和可调控靶标。发现氧化还原通路稳态失衡是灵长类卵巢衰老的主要分子特征,为评价卵巢衰老及女性生殖力下降提供了新型生物学标志物,;阐明热量限制(七分饱)可通过调节机体各组织的免疫炎症通路,延缓多器官衰老的新型分子机制。这些研究成果加深了人们对器官衰老异质性和复杂性的理解,为建立针对衰老及衰老相关疾病的早期预警和科学应对策略奠定了重要基础。

It is in China's national needs to conduct systematic investigation of and take active response to population aging. The research team collaborated to systematically reveal new biomarkers and therapeutic targets of multi-organ aging in mammals. We identified cell-type-specific inactivation of antioxidant genes as a hallmark of primate ovarian aging, providing new biomarkers for the assessment of ovarian aging and female progressive reproductive decline. The research team also clarified the molecular mechanism of calorie restriction that delays multi-organ aging by repressing pro-inflammatory pathways. These findings have deepened our understanding of the heterogeneity and complexity of organ aging and laid an important foundation for early prognosis and therapeutic interventions of aging and aging-related diseases.

卡路里限制延缓多器官衰老的系统生物学研究