081703-生物化工
071005-微生物学

生物化工
微生物代谢工程

2005-07--2010-07   山东大学微生物技术国家重点实验室   硕博士研究生
2000-09--2004-07   山东大学   学士

   

2020-08~现在, 中国科学院青岛生物能源与过程研究所, 系统微生物工程研究组组长
2017-07~2020-08,中国科学院青岛生物能源与过程研究所, 生物基材料组群-精细化学品研究组组长
2016-11~2017-07,中国科学院青岛生物能源与过程研究所, 创新组组长
2016-10~2016-11,美国麻省理工学院, 访问学者
2010-07~2016-10,中国科学院青岛生物能源与过程研究所, 助研/副研
2000-09~2004-07,山东大学国家糖工程中心, 研究助理

2021-03-01-今,Frionter in Microbiology客座编辑,
2014-06-18-2016-06-18,《微生物前沿》编委,

   

（1） 闵恩泽能源化工青年进步奖, 一等奖, 部委级, 2017

（ 1 ） 一株高地芽孢杆菌及其在产高稳定性碱性 果胶酶中的应用, 发明专利, 2022, 第 1 作者, 专利号: CN114317364A

（ 2 ） 一种基于开放式发酵的微生物耐盐多糖的制备工艺, 发明专利, 2022, 第 1 作者, 专利号: 202210276843.9

（ 3 ） 一种纳米银辅助开放式发酵生产细菌纤维素膜的方法, 发明专利, 2022, 第 1 作者, 专利号: 202210263860.9

（ 4 ） 一种异戊二烯合酶和其编码基因、表达载体、工程菌以及生产异戊二烯的方法及应用, 专利授权, 2021, 第 3 作者, 专利号: CN109097378B

（ 5 ） 一种烟叶生物质直接液态发酵生产生物基化学品的方法, 发明专利, 2021, 第 1 作者, 专利号: 202110845667.1

（ 6 ） 一种来源于肠杆菌的双向启动子及其应用, 发明专利, 2021, 第 1 作者, 专利号: 202110843870.5

（ 7 ） 一种同时生产生长素和2-苯乙醇的方法及其应用, 发明专利, 2021, 第 1 作者, 专利号: 202110840917.2

（ 8 ） 一种雪茄外包皮烟叶保湿的方法, 发明专利, 2021, 第 1 作者, 专利号: CN113040410A

（ 9 ） 一种具有γ-松油烯合成能力的基因工程菌及其构建方法与应用, 专利授权, 2020, 第 1 作者, 专利号: CN107354118B

（ 10 ） 一种细胞表面展示有豆壳过氧化物酶的重组酵母菌及其构建方法与应用, 专利授权, 2020, 第 3 作者, 专利号: CN108085332B

（ 11 ） 一种泰乐菌素降解菌及其筛选方法与应用, 发明专利, 2020, 第 1 作者, 专利号: CN111893059A

（ 12 ） 一种高产法尼烯的基因工程菌及其构建方法与应用, 发明专利, 2020, 第 1 作者, 专利号: CN111607546A

（ 13 ） 一种高产法尼烯的重组菌及其构建方法与应用, 发明专利, 2020, 第 1 作者, 专利号: CN111607545A

（ 14 ） 一种烟叶醇化过程中微生物群落演替的分析方法, 发明专利, 2020, 第 1 作者, 专利号: CN111187850A

（ 15 ） 一种烟草废弃物的处理方法及其应用, 发明专利, 2020, 第 1 作者, 专利号: CN111185458A

（ 16 ） 一种合成法尼烯的基因工程菌及其构建方法与应用, 发明专利, 2020, 第 3 作者, 专利号: CN110964678A

（ 17 ） 一种二硝基甲苯磺酸钠降解菌及其筛选方法与应用, 发明专利, 2020, 第 3 作者, 专利号: CN110964652A

（ 18 ） 一种功能性细菌纤维素的制备方法, 发明专利, 2020, 第 2 作者, 专利号: CN110951802A

（ 19 ） 一种雪茄茄芯烟叶的四段式发酵方法, 发明专利, 2020, 第 1 作者, 专利号: CN110693075A

（ 20 ） 一种降低雪茄烟叶堆垛过程中烧堆风险的两段式发酵方法, 发明专利, 2020, 第 2 作者, 专利号: CN110638087A

（ 21 ） 一种利用宏基因组测序辅助筛选烟草发酵过程中微生物的方法, 专利授权, 2019, 第 1 作者, 专利号: CN109112067B

（ 22 ） 一株特基拉芽孢杆菌CAS-MEI-2-33及其应用, 发明专利, 2019, 第 1 作者, 专利号: CN109957522A

（ 23 ） 一种微球菌及其在生产2,3-丁二醇中的应用, 发明专利, 2019, 第 3 作者, 专利号: CN109797114A

（ 24 ） 一种合成桧烯的基因工程菌及其构建方法与应用, 发明专利, 2019, 第 3 作者, 专利号: CN109777745A

（ 25 ） 一种产黑色素短梗霉在联产普鲁兰多糖和苯乙醇中的应用, 发明专利, 2019, 第 2 作者, 专利号: CN109321608A

（ 26 ） 一种适宜在碱性条件下生产高分子、无色素普鲁兰多糖的菌株及其应用, 发明专利, 2018, 第 2 作者, 专利号: CN107760609A

（ 27 ） 一种高效生产低分子普鲁兰多糖的诱变菌株及其应用, 发明专利, 2018, 第 1 作者, 专利号: CN107760608A

（ 28 ） 耐热β‑淀粉酶‑海藻糖合成酶融合酶、其表达基因以及分泌该融合酶的工程菌与应用, 发明专利, 2017, 第 1 作者, 专利号: CN107254459A

（ 29 ） 一种纳米级细菌纤维素膜的制备方法及应用, 发明专利, 2016, 第 4 作者, 专利号: CN105821094A

（ 30 ） 一种生物法合成α-或β-蒎烯的方法, 发明专利, 2014, 第 4 作者, 专利号: CN104120148A

（ 31 ） 一种高性能类蛛丝蛋白材料及其生物合成方法, 发明专利, 2014, 第 2 作者, 专利号: CN103833838A

（ 32 ） 一种采用细胞融合技术生产异戊二烯的方法及其构建的融合子, 发明专利, 2014, 第 3 作者, 专利号: CN103571820A

（ 33 ） 一种采用高纤维素水解液耐受性大肠杆菌生产生物基化学品的方法, 发明专利, 2014, 第 2 作者, 专利号: CN103571773A

（ 34 ） 一种利用纤维素水解液合成生物基化学品的恶臭假单胞菌及其应用, 发明专利, 2014, 第 2 作者, 专利号: CN103571774A

（ 35 ） 一株以葡萄糖为碳源合成2-苯乙醇的肠杆菌, 发明专利, 2013, 第 2 作者, 专利号: CN103131645A

（ 36 ） 一种提高工程大肠杆菌间苯三酚合成能力的方法, 发明专利, 2012, 第 4 作者, 专利号: CN102787135A

（ 37 ） 筛选生产底物广泛性的腈水解酶的菌株的方法, 发明专利, 2012, 第 2 作者, 专利号: CN102690766A

（ 38 ） 一种生物催化1,3-二噁烷转化制备1,3-丙二醇的方法, 发明专利, 2012, 第 7 作者, 专利号: CN102586341A

（ 39 ） 一种制备异戊二烯的重组细胞及其制备方法, 发明专利, 2012, 第 5 作者, 专利号: CN102559769A

（ 40 ） 一种可降解材料及制备方法和应用, 发明专利, 2012, 第 3 作者, 专利号: CN102336300A

   

[1] Wenzhi Bao, Xing Li, Jinfeng Liu, Rong Zheng, Lijuan Liu, Haibo Zhang. The Characterization of an Efficient Phenylpyruvate Decarboxylase KDC4427, Involved in 2-Phenylethanol and IAA Production from Bacterial Enterobacter sp. CGMCC 5087. Microbiology Spectrum[J]. 2022, https://journals.asm.org/doi/epub/10.1128/spectrum.02660-21.
[2] Lijuan Liu, Wenzhi Bao, Xiao Men, Haibo Zhang. Engineering for life in toxicity: key to industrializing microbial synthesis of high energy density fuels. Engineering Microbiology[J]. 2022, 2(2): [3] Shuaijun Deng, Ge Zhang, OluwaseunOlayemi Aluko, Zhijie Mo, Jingjing Mao, Haibo Zhang, Xiaohui Liu, Ming Ma, Qian Wang, Haobao Liu. Bitter and astringent substances in green tea: composition, human perception mechanisms, evaluation methods and factors influencing their formation. Food Research International[J]. 2022, https://www.sciencedirect.com/science/article/pii/S0963996922003192.
[4] Xiaoqi Zhao, Guoqiang Chen, Fan Wang, Han Zhao, Yuxi Wei, Lijuan Liu, Haibo Zhang. Extraction, characterization, antioxidant activity and rheological behavior of a polysaccharide produced by the extremely salt tolerant Bacillus subtilis LR-1. LWT- Food Science and Technology[J]. 2022, https://www.sciencedirect.com/science/article/pii/S0023643822003486.
[5] 李志豪, 张鸽, 貊志杰, 邓帅军, 李佳轶, 张海波, 刘晓晖, 刘好宝. 一株产木聚糖酶的蜡样芽孢杆菌对雪茄烟叶成分及发酵产物的影响. 生物技术通报[J]. 2022, 38(2): 105-112, http://lib.cqvip.com/Qikan/Article/Detail?id=7106696612.
[6] Han, Ju, Wang, Fan, Li, Zhihao, Liu, Lijuan, Zhang, Ge, Chen, Guoqiang, Liu, Jing, Zhang, Haibo. Isolation and identification of an osmotolerant Bacillus amyloliquefaciens strain T4 for 2, 3-butanediol production with tobacco waste. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY[J]. 2021, http://dx.doi.org/10.1080/10826068.2021.1925912.
[7] 张鸽, 张海波, 李志豪, 邓帅军, 李东亮, 张良, 蔡斌, 王娟, 王帆, 陈国强, 张海波, 刘好宝. 海南H382雪茄烟叶不同发酵周期细菌群落多样性表征及演替分析. 中国烟草学报[J]. 2021, [8] 包文智, 李兴, 张海波, 峥嵘, 刘丽娟. rpoS基因在肠杆菌CGMCC 5087响应环境胁迫中的功能. 微生物学通报[J]. 2021, 48(1): 104-112, http://lib.cqvip.com/Qikan/Article/Detail?id=7104294306.
[9] Wang, Jiming, Wang, Chaoming, Men, Xiao, Yue, Tongqin, Madzak, Catherine, Xiang, Xiaohua, Xiang, Haiying, Zhang, Haibo. Construction of arming Yarrowia lipolytica surface-displaying soybean seed coat peroxidase for use as whole-cell biocatalyst. ENZYME AND MICROBIAL TECHNOLOGY[J]. 2020, 135: http://dx.doi.org/10.1016/j.enzmictec.2019.109498.
[10] 徐镇祥, 李美洁, 门潇, 陈国强, 王纪明, 咸漠, 张海波. 甲羟戊酸途径的代谢支路调控策略的研究进展. 生物加工过程[J]. 2020, 18(1): 44-51, https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C44YLTlOAiTRKibYlV5Vjs7i8oRR1PAr7RxjuAJk4dHXos_Ux283gQgLh0v1wOSGO9PtNOgOeBkGljO_jHHs3jDG&uniplatform=NZKPT.
[11] Fan Wang, Dongxiang Shi, Ju Han, Ge Zhang, Xinglin Jiang, Mingjun Yang, Zhenying Wu, Chunxiang Fu, Zhihao Li, Mo Xian, Haibo Zhang. Comparative Study on Pretreatment Processes for Different Utilization Purposes of Switchgrass. ACS OMEGA[J]. 2020, 5(35): 21999-22007, https://www.webofscience.com/wos/woscc/full-record/WOS:000570009400003.
[12] Li, Meijie, Hou, Feifei, Wu, Tong, Jiang, Xinglin, Li, Fuli, Liu, Haobao, Xian, Mo, Zhang, Haibo. Recent advances of metabolic engineering strategies in natural isoprenoid production using cell factories. NATURAL PRODUCT REPORTSnull. 2020, 37(1): 80-99, http://dx.doi.org/10.1039/c9np00016j.
[13] Jiang, Xinglin, Palazzotto, Emilia, Wybraniec, Ewa, Munro, Lachlan Jake, Zhang, Haibo, Kell, Douglas B, Weber, Tilmann, Lee, Sang Yup. Automating Cloning by Natural Transformation. ACS SYNTHETIC BIOLOGY[J]. 2020, 9(12): 3228-3235, http://dx.doi.org/10.1021/acssynbio.0c00240.
[14] Wu, Tong, Liu, Jinfeng, Li, Meijie, Zhang, Ge, Liu, Lijuan, Li, Xing, Men, Xiao, Xian, Mo, Zhang, Haibo. Improvement of sabinene tolerance of Escherichia coli using adaptive laboratory evolution and omics technologies. BIOTECHNOLOGY FOR BIOFUELS[J]. 2020, 13(1): http://dx.doi.org/10.1186/s13068-020-01715-x.
[15] 霍明月, 张鸽, 苏玉龙, 李兴, 张海波, 峥嵘, 刘好宝. 一株耐受高浓度葡萄糖且产乙偶姻菌株的筛选及产物鉴定. 生物技术通报[J]. 2020, 36(8): 53-60, http://lib.cqvip.com/Qikan/Article/Detail?id=7102585427.
[16] 曹小贺, 张海波, 包文智, 刘丽娟, 夏海锋. 提高酿酒酵母异戊二烯产量的代谢途径的挖掘. 食品与发酵工业[J]. 2020, 46(12): 1-7, http://lib.cqvip.com/Qikan/Article/Detail?id=7102084068.
[17] Li, Meijie, Liu, Changqing, Yang, Jianming, Nian, Rui, Xian, Mo, Li, Fuli, Zhang, Haibo. Common problems associated with the microbial productions of aromatic compounds and corresponding metabolic engineering strategies. BIOTECHNOLOGY ADVANCESnull. 2020, 41: http://dx.doi.org/10.1016/j.biotechadv.2020.107548.
[18] Chen, Hailin, Li, Meijie, Liu, Changqing, Zhang, Haibo, Xian, Mo, Liu, Huizhou. Enhancement of the catalytic activity of Isopentenyl diphosphate isomerase (IDI) from Saccharomyces cerevisiae through random and site-directed mutagenesis (vol 17, 65, 2018). MICROBIAL CELL FACTORIESnull. 2020, 19(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000513891500002.
[19] Li, Meijie, Xia, Qingqing, Zhang, Haibo, Zhang, Rubing, Yang, Jianming. Metabolic Engineering of Different Microbial Hosts for Lycopene Production. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRYnull. 2020, 68(48): 14104-14122, https://www.webofscience.com/wos/woscc/full-record/WOS:000596914400002.
[20] Zhang, Ge, Li, Shugui, Xu, Yingbo, Wang, Juan, Wang, Fan, Xin, Yuhua, Shen, Zhong, Zhang, Haibo, Ma, Ming, Liu, Haobao. Production of alkaline pectinase: a case study investigating the use of tobacco stalk with the newly isolated strain Bacillus tequilensis CAS-MEI-2-33. BMC BIOTECHNOLOGY[J]. 2019, 19(1): http://dx.doi.org/10.1186/s12896-019-0526-6.
[21] Chen, Guoqiang, Zhu, Youshuang, Zhang, Ge, Liu, Haobao, Wei, Yuxi, Wang, Pinggui, Wang, Fan, Xian, Mo, Xiang, Haiying, Zhang, Haibo. Optimization and characterization of pullulan production by a newly isolated high-yielding strain Aureobasidium melanogenum. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY[J]. 2019, 49(6): 557-566, https://www.webofscience.com/wos/woscc/full-record/WOS:000465957400001.
[22] Li, Meijie, Chen, Hailin, Liu, Changqing, Guo, Jing, Xu, Xin, Zhang, Haibo, Nian, Rui, Xian, Mo. Improvement of isoprene production in Escherichia coli by rational optimization of RBSs and key enzymes screening. MICROBIAL CELL FACTORIES[J]. 2019, 18(1): https://doaj.org/article/4f969fc6f48c41c1bbf7471931db4726.
[23] Xu, Zhenxiang, Chen, Guoqiang, Xue, Le, Zhang, Haibo, Wang, Jiming, Xiang, Haiying, Li, Jinglong, Zheng, Kai. Isolation, structural characterizations and bioactivities of exopolysaccharides produced by Bacillus licheniformis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2019, 141: 298-306, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000506713000031.
[24] Chen, Hailin, Liu, Changqing, Li, Meijie, Zhang, Haibo, Xian, Mo, Liu, Huizhou. Directed evolution of mevalonate kinase in Escherichia coli by random mutagenesis for improved lycopene (vol 8, pg 15021, 2018). RSC ADVANCESnull. 2019, 9(16): 8934-8934, [25] 王娟, 王帆, 张鸽, 辛玉华, 张海波, 刘好宝. 烤烟烟叶淀粉含量5种测定方法的比较. 分子植物育种[J]. 2019, 1673-1678, http://lib.cqvip.com/Qikan/Article/Detail?id=70909087504849574853485157.
[26] Li, Meijie, Liu, Changqing, Chen, Hailin, Deng, Li, Zhang, Haibo, Nian, Rui, Xian, Mo. Biochemical characterization of isoprene synthase from Ipomoea batatas. JOURNAL OF BIOSCIENCE AND BIOENGINEERING[J]. 2019, 127(2): 138-144, http://dx.doi.org/10.1016/j.jbiosc.2018.07.022.
[27] Minghong Gao, Juan Li, Zixian Bao, Moudong Hu, Rui Nian, Dexin Feng, Dong An, Xing Li, Mo Xian, Haibo Zhang. A natural in situ fabrication method of functional bacterial cellulose using a microorganism. NATURE COMMUNICATIONS[J]. 2019, 10(1): 1-10, https://doaj.org/article/dbc7ea057c2c457da85dd2bdb225985e.
[28] Qi, Chang, Zhao, Hongwei, Li, Wenyang, Li, Xing, Xiang, Haiying, Zhang, Ge, Liu, Haobao, Wang, Qian, Wang, Yi, Xian, Mo, Zhang, Haibo. Production of gamma-terpinene by metabolically engineered Escherichia coli using glycerol as feedstock. RSC ADVANCES[J]. 2018, 8(54): 30851-30859, https://www.webofscience.com/wos/woscc/full-record/WOS:000444700500026.
[29] Li, Meijie, Nian, Rui, Xian, Mo, Zhang, Haibo. Metabolic engineering for the production of isoprene and isopentenol by Escherichia coli. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2018, 102(18): 7725-7738, http://ir.qibebt.ac.cn/handle/337004/11890.
[30] 张鸽, 梁开朝, 辛玉华, 王娟, 李书贵, 王帆, 张海波, 刘好宝. 四个国家雪茄外包皮烟叶表面细菌分离与活性测定. 中国烟草科学[J]. 2018, 39(2): 82-88, http://lib.cqvip.com/Qikan/Article/Detail?id=7000645625.
[31] Wang, Fan, Men, Xiao, Zhang, Ge, Liang, Kaichao, Xin, Yuhua, Wang, Juan, Li, Aijun, Zhang, Haibo, Liu, Haobao, Wu, Lijun. Assessment of 16S rRNA gene primers for studying bacterial community structure and function of aging flue-cured tobaccos. AMB EXPRESS[J]. 2018, 8(1): http://ir.qibebt.ac.cn/handle/337004/11013.
[32] Liu, Changqing, Zhang, Kai, Cao, Wenyan, Zhang, Ge, Chen, Guoqiang, Yang, Haiyan, Wang, Qian, Liu, Haobao, Xian, Mo, Zhang, Haibo. Genome mining of 2-phenylethanol biosynthetic genes from Enterobacter sp CGMCC 5087 and heterologous overproduction in Escherichia coli. BIOTECHNOLOGY FOR BIOFUELS[J]. 2018, 11(1): http://ir.qibebt.ac.cn/handle/337004/10998.
[33] Cao, Yujin, Zhang, Haibo, Liu, Hui, Liu, Wei, Zhang, Rubing, Xian, Mo, Liu, Huizhou. Biosynthesis and production of sabinene: current state and perspectives. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2018, 102(4): 1535-1544, [34] 吴丽君, 梁开朝, 王帆, 高锐, 王毅, 段如敏, 刘好宝, 张海波, 白晓莉. 增香细菌HD-7的鉴定及香气成分分析. 天然产物研究与开发[J]. 2018, 30(2): 246-250, http://lib.cqvip.com/Qikan/Article/Detail?id=7000474822.
[35] 张鸽, 梁开朝, 辛玉华, 王娟, 李书贵, 李爱军, 王帆, 张海波, 刘好宝. 基于高通量测序和传统分离研究雪茄外包皮表面细菌多样性及演替. 应用与环境生物学报[J]. 2018, 24(4): 783-788, http://lib.cqvip.com/Qikan/Article/Detail?id=676217420.
[36] Wang, Fan, Zhao, Hongwei, Xiang, Haiying, Wu, Lijun, Men, Xiao, Qi, Chang, Chen, Guoqiang, Zhang, Haibo, Wang, Yi, Xian, Mo. Species Diversity and Functional Prediction of Surface Bacterial Communities on Aging Flue-Cured Tobaccos. CURRENT MICROBIOLOGY[J]. 2018, 75(10): 1306-1315, http://ir.qibebt.ac.cn/handle/337004/12208.
[37] Chen, Hailin, Liu, Changqing, Li, Meijie, Zhang, Haibo, Xian, Mo, Liu, Huizhou. Directed evolution of mevalonate kinase in Escherichia coli by random mutagenesis for improved lycopene. RSC ADVANCES[J]. 2018, 8(27): 15021-15028, http://www.irgrid.ac.cn/handle/1471x/1782359.
[38] Xiao Men, Fan Wang, GuoQiang Chen, HaiBo Zhang, Mo Xian. Biosynthesis of Natural Rubber: Current State and Perspectives. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2018, 20(1): https://doaj.org/article/ca1489dc6ecd461da1b19c7de85001e1.
[39] Liu, Changqing, Men, Xiao, Chen, Hailin, Li, Meijie, Ding, Zhaorui, Chen, Guoqiang, Wang, Fan, Liu, Haobao, Wang, Qian, Zhu, Youshuang, Zhang, Haibo, Xian, Mo. A systematic optimization of styrene biosynthesis in Escherichia coli BL21(DE3). BIOTECHNOLOGY FOR BIOFUELS[J]. 2018, 11(1): https://doaj.org/article/7f539cc8ae6643f685ce446674b963ae.
[40] Chen, Hailin, Li, Meijie, Liu, Changqing, Zhang, Haibo, Xian, Mo, Liu, Huizhou. Enhancement of the catalytic activity of Isopentenyl diphosphate isomerase (IDI) from Saccharomyces cerevisiae through random and site-directed mutagenesis. MICROBIAL CELL FACTORIES[J]. 2018, 17(1): http://www.irgrid.ac.cn/handle/1471x/1782354.
[41] Zhao, Hongwei, Xia, Jian, Wang, Jiming, Yan, Xiaofei, Wang, Cong, Lei, Tingzhou, Xian, Mo, Zhang, Haibo. Production of bacterial cellulose using polysaccharide fermentation wastewater as inexpensive nutrient sources. BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT[J]. 2018, 32(2): 350-356, http://www.irgrid.ac.cn/handle/1471x/1755519.
[42] Liu, Hui, Cheng, Tao, Zou, Huibin, Zhang, Haibo, Xu, Xin, Sun, Chao, Aboulnaga, Elhussiny, Cheng, Zhongkai, Zhao, Guang, Xian, Mo. High titer mevalonate fermentation and its feeding as a building block for isoprenoids (isoprene and sabinene) production in engineered Escherichia coli. PROCESS BIOCHEMISTRY[J]. 2017, 62: 1-9, http://dx.doi.org/10.1016/j.procbio.2017.07.021.
[43] Chen, Guoqiang, Wang, Jiming, Su, Yulong, Zhu, Youshuang, Zhang, Ge, Zhao, Hongwei, Liu, Haobao, Yang, Ying, Nian, Rui, Zhang, Haibo, Wei, Yuxi, Xian, Mo. Pullulan production from synthetic medium by a new mutant of Aureobasidium pullulans. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY[J]. 2017, 47(10): 963-969, https://www.webofscience.com/wos/woscc/full-record/WOS:000418064000003.
[44] Zhao, Hongwei, Li, Jingyuan, Wang, Jiming, Xu, Xin, Xian, Mo, Liu, Huizhou, Zhang, Haibo. Calcium Supplementation Abates the Inhibition Effects of Acetic Acid on Saccharomyces cerevisiae. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY[J]. 2017, 181(4): 1573-1589, http://ir.qibebt.ac.cn/handle/337004/9290.
[45] Zhao Hongwei, Li Jingyuan, Wang Jiming, Xu Xin, Xian Mo, Liu Huizhou, Zhang Haibo. Calcium Supplementation Abates the Inhibition Effects of Acetic Acid on Saccharomyces cerevisiae. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY[J]. 2017, [46] Liu, Changqing, Zheng, Kai, Xu, Ying, Stephen, Lacmata Tamekou, Wang, Jiming, Zhao, Hongwei, Yue, Tongqing, Nian, Rui, Zhang, Haibo, Xian, Mo, Liu, Huizhou. Expression and characterization of soybean seed coat peroxidase in Escherichia coli BL21(DE3). PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY[J]. 2017, 47(8): 768-775, http://www.irgrid.ac.cn/handle/1471x/1755786.
[47] 陈泉, 卓燕玲, 许爱娜, 咸漠, 彭馨莹, 杨元生, 张海波, 年锐, 张巍. 蛋白A亲和层析法纯化单克隆抗体工艺的优化. 生物工程学报[J]. 2016, 32(6): 1−12-, http://ir.qibebt.ac.cn/handle/337004/8589.
[48] Li, QianZhu, Jiang, XingLin, Feng, XinJun, Wang, JiMing, Sun, Chao, Zhang, HaiBo, Xian, Mo, Liu, HuiZhou. Recovery Processes of Organic Acids from Fermentation Broths in the Biomass-Based Industry. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2016, 26(1): 1-8, http://dx.doi.org/10.4014/jmb.1505.05049.
[49] Chen, Quan, Toh, Phyllicia, Sun, Yue, Latiff, Sarah Maria Abdul, Hoi, Aina, Xian, Mo, Zhang, Haibo, Nian, Rui, Zhang, Wei, Gagnon, Pete. Histone-dependent IgG conservation in octanoic acid precipitation and its mechanism. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2016, 100(23): 9933-9941, http://dx.doi.org/10.1007/s00253-016-7719-x.
[50] Zheng, Yanning, Li, Lingling, Liu, Qiang, Zhang, Haibo, Cao, Yujin, Xian, Mo, Liu, Huizhou. High-specificity synthesis of novel monomers by remodeled alcohol hydroxylase. BMC BIOTECHNOLOGY[J]. 2016, 16(1): http://ir.qibebt.ac.cn/handle/337004/8498.
[51] Zhang, Haibo, Zhou, Fengli, Jiang, Xinglin, Cao, Mingle, Wang, Shilu, Zou, Huibin, Cao, Yujin, Xian, Mo, Liu, Huizhou. Microbial production of amino acid-modified spider dragline silk protein with intensively improved mechanical properties. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY[J]. 2016, 46(6): 552-558, http://www.irgrid.ac.cn/handle/1471x/1110004.
[52] Chen, Dawei, Liang, Fengbing, Feng, Dexin, Xian, Mo, Zhang, Haibo, Liu, Huizhou, Du, Fanglin. An efficient route from reproducible glucose to 5-hydroxymethylfurfural catalyzed by porous coordination polymer heterogeneous catalysts. CHEMICAL ENGINEERING JOURNAL[J]. 2016, 300: 177-184, http://dx.doi.org/10.1016/j.cej.2016.04.039.
[53] Chen, Quan, Latiff, Sarah Maria Abdul, Toh, Phyllicia, Peng, Xinying, Hoi, Aina, Xian, Mo, Zhang, Haibo, Nian, Rui, Zhang, Wei, Gagnon, Pete. A simple and efficient purification platform for monoclonal antibody production based on chromatin-directed cell culture clarification integrated with precipitation and void-exclusion anion exchange chromatography. JOURNAL OF BIOTECHNOLOGY[J]. 2016, 236: 128-140, http://dx.doi.org/10.1016/j.jbiotec.2016.08.014.
[54] Sun, Weizhi, Liu, Yaojie, Zhang, Haibo, Xian, Mo, Liu, Huizhou. Biomimetic Nitration of Phenols Using Metalloporphyrins/H2O2/NO2 (-). CATALYSIS LETTERS[J]. 2015, 145(11): 1991-1999, http://www.irgrid.ac.cn/handle/1471x/1001164.
[55] Feng, Xinjun, Xian, Mo, Liu, Wei, Xu, Chao, Zhang, Haibo, Zhao, Guang. Biosynthesis of poly(3-hydroxypropionate) from glycerol using engineered Klebsiella pneumoniae strain without vitamin B-12. BIOENGINEERED[J]. 2015, 6(2): 77-81, http://ir.qibebt.ac.cn/handle/337004/8603.
[56] Zhang, H., Liu, Q., Cao, Y., Feng, X., Zheng, Y., Zou, H., Xian, M.. Microbial production of sabinene--a new terpene-based precursor of advanced biofuel. MICROB CELL FACT[J]. 2014, 13(20): 1-, http://ir.qibebt.ac.cn/handle/337004/8754.
[57] Zhang, Haibo, Liu, Qiang, Cao, Yujin, Feng, Xinjun, Zheng, Yanning, Zou, Huibin, Liu, Hui, Yang, Jianming, Xian, Mo. Microbial production of sabinene-a new terpene-based precursor of advanced biofuel. MICROBIAL CELL FACTORIES[J]. 2014, 13(1): 20-20, http://ir.qibebt.ac.cn/handle/337004/12577.
[58] 张海波. Non-mediated oxidation of non-phenol dye methyl red with purified laccase from Trametes hirsuta lg-9. Journal of Pure and Applied Microbiology. 2014, [59] Zhang, Haibo, Cao, Mingle, Jiang, Xinglin, Zou, Huibin, Wang, Cong, Xu, Xin, Xian, Mo. De-novo synthesis of 2-phenylethanol by Enterobacter sp CGMCC 5087. BMC BIOTECHNOLOGY[J]. 2014, 14(1): http://ir.qibebt.ac.cn/handle/337004/12561.
[60] Cao, Yujin, Liu, Wei, Xu, Xin, Zhang, Haibo, Wang, Jiming, Xian, Mo. Production of free monounsaturated fatty acids by metabolically engineered Escherichia coli. BIOTECHNOLOGY FOR BIOFUELS[J]. 2014, 7(1): http://ir.qibebt.ac.cn/handle/337004/6298.
[61] 张海波. De-novo Synthesis of 2-Phenylethanol by Enterobacter s CGMCC 5087. BMC Biotechnology. 2014, [62] Li, Q., Jiang, X., Zou, H., Cao, Z., Zhang, H., Xian, M.. Extraction of short-chain organic acids using imidazolium-based ionic liquids from aqueous media. 查不到[J]. 2014, 6(5): 374-381, http://ir.qibebt.ac.cn/handle/337004/8714.
[63] Zheng, Yanning, Liu, Qiang, Li, Lingling, Qin, Wen, Yang, Jianming, Zhang, Haibo, Jiang, Xinglin, Cheng, Tao, Liu, Wei, Xu, Xin, Xian, Mo. Metabolic engineering of Escherichia coli for high-specificity production of isoprenol and prenol as next generation of biofuels. BIOTECHNOLOGY FOR BIOFUELS[J]. 2013, 6(1): 57-57, http://www.irgrid.ac.cn/handle/1471x/830136.
[64] Yang, Jianming, Nie, Qingjuan, Ren, Meng, Feng, Hongru, Jiang, Xinglin, Zheng, Yanning, Liu, Min, Zhang, Haibo, Xian, Mo. Metabolic engineering of Escherichia coli for the biosynthesis of alpha-pinene. BIOTECHNOLOGY FOR BIOFUELS[J]. 2013, 6(1): 60-60, http://www.irgrid.ac.cn/handle/1471x/830135.
[65] 王纪明, 刘炜, 徐鑫, 张海波, 咸漠. 工程大肠杆菌生产高附加值有机酸， 醇研究进展. CHINESE JOURNAL OF BIOTECHNOLOGY[J]. 2013, 29(1): 1-, http://ir.qibebt.ac.cn/handle/337004/8900.
[66] Wang, Qian, Song, Yufeng, Jin, Yirong, Liu, Haobao, Zhang, Haibo, Sun, Yuhe, Liu, Guanshan. Biosynthesis of 2-phenylethanol using tobacco waste as feedstock. BIOCATALYSIS AND BIOTRANSFORMATION[J]. 2013, 31(6): 292-298, http://dx.doi.org/10.3109/10242422.2013.857315.
[67] Cao, Yujin, Xian, Mo, Zou, Huibin, Zhang, Haibo. Metabolic Engineering of Escherichia coli for the Production of Xylonate. PLOS ONE[J]. 2013, 8(7): http://www.irgrid.ac.cn/handle/1471x/830128.
[68] 曹明乐, 姜兴林, 张海波, 咸漠, 徐鑫, 刘炜. 一株产腈水解酶的泛菌及其催化特征. 应用与环境生物学报[J]. 2013, 19(2): 346-350, http://www.irgrid.ac.cn/handle/1471x/830121.
[69] Jiang, Xinglin, Zhang, Haibo, Yang, Jianming, Zheng, Yanning, Feng, Dexin, Liu, Wei, Xu, Xin, Cao, Yujin, Zou, Huibin, Zhang, Rubin, Cheng, Tao, Jiao, Fengjiao, Xian, Mo. Biodegradation-inspired bioproduction of methylacetoin and 2-methyl-2,3-butanediol (vol 3, 2445, 2013). SCIENTIFIC REPORTS. 2013, 3(1): http://www.irgrid.ac.cn/handle/1471x/1001140.
[70] Jiang, Xinglin, Zhang, Haibo, Yang, Jianming, Liu, Min, Feng, Hongru, Liu, Xiaobin, Cao, Yujin, Feng, Dexin, Xian, Mo. Induction of gene expression in bacteria at optimal growth temperatures. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2013, 97(12): 5423-5431, http://www.irgrid.ac.cn/handle/1471x/830130.
[71] Jiang, Xinglin, Zhang, Haibo, Yang, Jianming, Zheng, Yanning, Feng, Dexin, Liu, Wei, Xu, Xin, Cao, Yujin, Zou, Huibin, Zhang, Rubin, Cheng, Tao, Jiao, Fengjiao, Xian, Mo. Biodegradation-inspired bioproduction of methylacetoin and 2-methyl-2,3-butanediol. SCIENTIFIC REPORTS[J]. 2013, 3(3): http://www.irgrid.ac.cn/handle/1471x/830138.
[72] 曹明乐, 姜兴林, 张海波, 咸漠, 黄峰. 生物催化法生产2-苯乙醇的研究现状. 生物过程[J]. 2012, 2(2): 89-97, http://lib.cqvip.com/Qikan/Article/Detail?id=HS724002012002007.
[73] 曹明乐, 张海波, 黄峰, 咸漠. 漆酶的研究进展. 山东林业科技[J]. 2012, 42(3): 106-115, http://lib.cqvip.com/Qikan/Article/Detail?id=42439179.
[74] 曹明乐, 姜兴林, 张海波, 咸漠, 徐鑫, 刘炜. 新型假单胞菌对羟基苯乙腈水解酶及其性质研究. 生物过程[J]. 2012, 2(2): 70-74, http://lib.cqvip.com/Qikan/Article/Detail?id=HS724002012002004.
[75] Jiang, Xinglin, Yang, Jianming, Zhang, Haibo, Zou, Huibin, Wang, Cong, Xian, Mo. In Vitro Assembly of Multiple DNA Fragments Using Successive Hybridization. PLOS ONE[J]. 2012, 7(1): http://www.irgrid.ac.cn/handle/1471x/515905.

   

（ 1 ） 中国科学院青年促进会会员, 主持, 部委级, 2017-01--2020-12
（ 2 ） 海南雪茄特色发酵, 主持, 省级, 2017-06--2020-12
（ 3 ） 泰山学者青年专家, 主持, 省级, 2020-01--2024-12
（ 4 ） 微生物合成技术, 主持, 省级, 2021-01--2023-12

已指导学生

韩雪萍  硕士研究生  085238-生物工程  

吴桐  硕士研究生  085238-生物工程  

刘长青  硕士研究生  085238-生物工程  

韩菊  硕士研究生  081703-生物化工  

王帆  博士研究生  081703-生物化工  

现指导学生

张鸽  博士研究生  081703-生物化工  

陈国强  博士研究生  081703-生物化工