基本信息
秦燕  女  博导  中国科学院生物物理研究所
电子邮件: qiny@ibp.ac.cn
通信地址: 北京市大屯路15号
邮政编码: 100101

研究领域

1、核糖体生物学:蛋白质在核糖体上的生物合成过程的机理 

2、癌症与核糖体的关系:癌症发生、恶化、转移过程中的疾病模型、诊断、治疗

招生信息

   
招生方向
蛋白质翻译过程与肿瘤发生
核糖体,翻译调控
干细胞的分化
招生专业
071010-生物化学与分子生物学
071008-发育生物学
071009-细胞生物学

教育背景

   
学习经历
 1995/09-1999/06,南开大学,生命科学院生物系,本科
 2001/10-2003/04,德国柏林自由大学,化学院,硕士
 2003/05-2006/02,德国马-普学会分子遗传研究所/柏林自由大学化学院,博士 
 2006/03- , 德国马-普学会分子遗传研究所,博士后
 

工作经历

   
工作经历
2006年-今 中国科学院生物物理研究所研究员,RNA平台首席技术专家
2007年-今 中国科学院生物物理研究所,创新课题组长,博士生导师,中国科学院研究生院教授 (教授课程:结构生物学导论)
2014年-今 中国科学院大学岗位教授 (教授课程:分子生物学)
主要学术兼职
中国生物物理学会会员,脂代谢与生物能学分会委员
中国细胞生物学会会员
国家自然科学基金评审专家
北京市科委评审专家
教育部学位中心评审专家

教授课程

发现生命奥秘
科研论文写作-2班
科研论文写作
生物化学与分子生物学实验
结构生物学导论
结构生物学
课程名称
 分子生物学
 膜生物学

专利与奖励

专利:
     EF4蛋白编码基因沉默在癌症治疗方面的应用
     线粒体蛋白质翻译因子Guf1在雄性不育研究中的应用
     Use of LepA for improving the accuracy of protein synthesis in vitro
奖励:
      线粒体中的蛋白质翻译调控 优秀青年

出版信息

   
发表论文
[1] Xu, Xueting, Ahmed, Tanveer, Wang, Lulu, Cao, Xintao, Zhang, Zeyu, Wang, Ming, Lv, Yuan, Kanwal, Shahzina, Tariq, Muqddas, Lin, Runxia, Zhang, Hui, Huang, Yinghua, Peng, Hao, Lin, Danni, Shi, Xue, Geng, Didi, Liu, Baohua, Zhang, Xiaofei, Yi, Wen, Qin, Yan, Esteban, Miguel A, Qin, Baoming. The mTORC1-eIF4F axis controls paused pluripotency. EMBO REPORTS. 2021, [2] Zhang, Kexin, Jiao, Xiangyu, Zhou, Liping, Wang, Jian, Wang, Cheng, Qin, Yan, Wen, Yongqiang. Nanofibrous composite aerogel with multi-bioactive and fluid gating characteristics for promoting diabetic wound healing. BIOMATERIALS[J]. 2021, 276: http://dx.doi.org/10.1016/j.biomaterials.2021.121040.
[3] Yin, Xiaozhe, Zeng, Wenfeng, Wu, Bowen, Wang, Luoyang, Wang, Zihao, Tian, Hongjian, Wang, Luyao, Jiang, Yunhan, Clay, Ryan, Wei, Xiuli, Qin, Yan, Zhang, Fayun, Zhang, Chunling, Jin, Lingtao, Liang, Wei. PPAR alpha Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction. CELL REPORTS[J]. 2020, 33(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000582719300008.
[4] Zhang, Meng, Lai, Yiwei, Krupalnik, Vladislav, Guo, Pengcheng, Guo, Xiangpeng, Zhou, Jianguo, Xu, Yan, Yu, Zhijun, Liu, Longqi, Jiang, Ao, Li, Wenjuan, Ma, Gang, Li, Na, Fu, Xiuling, Lv, Yuan, Jiang, Mengling, Tariq, Muqddas, Kanwal, Shahzina, Liu, Hao, Xu, Xueting, Zhang, Hui, Huang, Yinghua, Wang, Lulu, Chen, Shuhan, Babarinde, Isaac A, Luo, Zhiwei, Wang, Dongye, Zhou, Tiantian, Ward, Carl, He, Minghui, Ibanez, David P, Li, Yunpan, Zhou, Jiajian, Yuan, Jie, Feng, Yayan, Arumugam, Karthik, Di Vicino, Umberto, Bao, Xichen, Wu, Guangming, Schambach, Axel, Wang, Huating, Sun, Hao, Gao, Fei, Qin, Baoming, Hutchins, Andrew P, Doble, Bradley W, Hartmann, Christine, Cosma, Maria Pia, Qin, Yan, Xu, GuoLiang, Chen, Runsheng, Volpe, Giacomo, Chen, Liang, Hanna, Jacob H, Esteban, Miguel A. beta-Catenin safeguards the ground state of mouse pluripotency by strengthening the robustness of the transcriptional apparatus. SCIENCE ADVANCES[J]. 2020, 6(29): https://www.webofscience.com/wos/woscc/full-record/WOS:000552227800011.
[5] Zhang, Kexin, Bai, Xiufeng, Yuan, Zhipeng, Cao, Xintao, Jiao, Xiangyu, Qin, Yan, Wen, Yongqiang, Zhang, Xueji. Cellular Nanofiber Structure with Secretory Activity-Promoting Characteristics for Multicellular Spheroid Formation and Hair Follicle Regeneration. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 12(7): 7931-7941, https://www.webofscience.com/wos/woscc/full-record/WOS:000515214300008.
[6] Song, Guangtao, Xu, Benjin, Shi, Huigang, Zhang, Yong, Zhang, Dejiu, Cao, Xintao, Liu, Zengrui, Guo, Ran, Guan, YanZhong, Chu, Yanhui, Zhang, Xinzheng, Lou, Jizhong, Qin, Yan. Conformational activation of ribosome recycling by intra- and inter-molecular dynamics of RRF. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2020, 160: 1212-1219, http://dx.doi.org/10.1016/j.ijbiomac.2020.05.254.
[7] Wu, Hao, Wei, Huifang, Zhang, Di, Sehgal, Sheikh Arslan, Zhang, Dejiu, Wang, Xiaohui, Qin, Yan, Liu, Lei, Chen, Quan. Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy. REDOX BIOLOGY[J]. 2020, 36: http://dx.doi.org/10.1016/j.redox.2020.101661.
[8] Wang, Luoyang, Zeng, Wenfeng, Wang, Luyao, Wang, Zihao, Yin, Xiaozhe, Qin, Yan, Zhang, Fayun, Zhang, Chunling, Liang, Wei. Naringenin Enhances the Antitumor Effect of Therapeutic Vaccines by Promoting Antigen Cross-Presentation. JOURNAL OF IMMUNOLOGY[J]. 2020, 204(3): 622-631, https://www.webofscience.com/wos/woscc/full-record/WOS:000508649800014.
[9] Zhang, Kexin, Bai, Xiufeng, Yuan, Zhipeng, Cao, Xintao, Jiao, Xiangyu, Li, Yansheng, Qin, Yan, Wen, Yongqiang, Zhang, Xueji. Layered nanofiber sponge with an improved capacity for promoting blood coagulation and wound healing. BIOMATERIALS[J]. 2019, 204: 70-79, http://dx.doi.org/10.1016/j.biomaterials.2019.03.008.
[10] Yan Qin. A brief review: the mitochondrial translation factor EF4 regulated mitochondrial respiratory chain and induced the production of ROS. Free Radical Res.. 2019, [11] Jin, Xiaohuan, Lv, Zhengyi, Gao, Junbao, Zhang, Rui, Zheng, Ting, Yin, Ping, Li, Dongqin, Peng, Liangcai, Cao, Xintao, Qin, Yan, Persson, Staffan, Zheng, Bo, Chen, Peng. AtTrm5a catalyses 1-methylguanosine and 1-methylinosine formation on tRNAs and is important for vegetative and reproductive growth in Arabidopsis thaliana. NUCLEIC ACIDS RESEARCH[J]. 2019, 47(2): 883-898, https://www.webofscience.com/wos/woscc/full-record/WOS:000467959100032.
[12] Zhang, Kai, Zhang, Xiaorong, Cai, Zhiqiang, Zhou, Jie, Cao, Ran, Zhao, Ya, Chen, Zonggui, Wang, Dehe, Ruan, Wen, Zhao, Qian, Liu, Guangqiao, Xue, Yuanchao, Qin, Yan, Zhou, Bing, Wu, Ligang, Nilsen, Timothy, Zhou, Yu, Fu, XiangDong. A novel class of microRNA-recognition elements that function only within open reading frames. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2018, 25(11): 1019-+, http://202.127.25.143/handle/331003/3372.
[13] Li, Guichen, Qin, Yan. Mitochondrial translation factor EF4 regulates oxidative phosphorylation complexes and the production of ROS. FREE RADICAL RESEARCHnull. 2018, 52(11-12): 1250-1255, https://www.webofscience.com/wos/woscc/full-record/WOS:000457432500006.
[14] 徐本锦, 宋广涛, 秦燕. 单分子荧光共振能量转移技术在核糖体移位研究中的进展. 生物化学与生物物理进展[J]. 2018, 45(3): 314-324, http://lib.cqvip.com/Qikan/Article/Detail?id=674827205.
[15] Xu BenJin, Song GuangTao, Qin Yan. smFRET Study Progress in The Dynamics of Ribosome Translocation. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2018, 45(3): 314-324, https://www.webofscience.com/wos/woscc/full-record/WOS:000428323500004.
[16] Wang, Fang, Zhang, Lingyun, Bai, Xiufeng, Cao, Xintao, Jiao, Xiangyu, Huang, Yan, Li, Yansheng, Qin, Yan, Wen, Yongqiang. Stimuli-Responsive Nanocarrier for Co-delivery of MiR-31 and Doxorubicin To Suppress High MtEF4 Cancer. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 10(26): 22767-22775, https://www.webofscience.com/wos/woscc/full-record/WOS:000438179000108.
[17] Zhu, Ping, Liu, Yongzhang, Zhang, Fenglin, Bai, Xiufeng, Chen, Zilei, Shangguan, Fugen, Zhang, Bo, Zhang, Lingyun, Chen, Qianqian, Xie, Deyao, Lan, Linhua, Xue, Xiangdong, Liang, XingJie, Lu, Bin, Wei, Taotao, Qin, Yan. Human Elongation Factor 4 Regulates Cancer Bioenergetics by Acting as a Mitochondrial Translation Switch. CANCER RESEARCH[J]. 2018, 78(11): 2813-2824, http://dx.doi.org/10.1158/0008-5472.CAN-17-2059.
[18] Zhou, ZhongYin, Hu, Yue, Li, Aimin, Li, YingJu, Zhao, Hui, Wang, SiQi, Otecko, Newton O, Zhang, Dejiu, Wang, JinHuan, Liu, Yajun, Irwin, David M, Qin, Yan, Zhang, YaPing. Genome wide analyses uncover allele-specific RNA editing in human and mouse. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(17): 8888-8897, http://159.226.149.26:8080/handle/152453/12400.
[19] Hao, Yajing, Zhang, Lili, Niu, Yiwei, Cai, Tanxi, Luo, Jianjun, He, Shunmin, Zhang, Bao, Zhang, Dejiu, Qin, Yan, Yang, Fuquan, Chen, Runsheng. SmProt: a database of small proteins encoded by annotated coding and non-coding RNA loci. BRIEFINGS IN BIOINFORMATICS[J]. 2018, 19(4): 636-643, https://www.webofscience.com/wos/woscc/full-record/WOS:000441243300010.
[20] Han, Qiusen, Wang, Xinhuan, Jia, Xinghang, Cai, Shuangfei, Liang, Wei, Qin, Yan, Yang, Rong, Wang, Chen. CpG loaded MoS2 nanosheets as multifunctional agents for photothermal enhanced cancer immunotherapy. NANOSCALE[J]. 2017, 9(18): 5927-5934, https://www.webofscience.com/wos/woscc/full-record/WOS:000401146200022.
[21] Liu, Zhida, Zhou, Chang, Qin, Yan, Wang, Zihao, Wang, Luyao, Wei, Xiuli, Zhou, Yinjian, Li, Qicheng, Zhou, Hang, Wang, Wenjun, Fu, YangXin, Zhu, Mingzhao, Liang, Wei. Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine. CELL DISCOVERY[J]. 2017, 3: 17007-, https://www.webofscience.com/wos/woscc/full-record/WOS:000414904200001.
[22] Chen Runsheng. SmProt: a database of small proteins encoded by annotated coding and non-coding RNA loci.. Brief Bioinform.. 2017, [23] Song, Guangtao, Qin, Yan. EF4 reveals the energy barrier for tRNA back-translocation in the peptidyl transferase center. RNA BIOLOGYnull. 2016, 13(10): 934-939, http://www.corc.org.cn/handle/1471x/2374865.
[24] Cao, Xintao, Qin, Yan. Mitochondrial translation factors reflect coordination between organelles and cytoplasmic translation via mTOR signaling: Implication in disease. FREE RADICAL BIOLOGY AND MEDICINEnull. 2016, 100: 231-237, http://dx.doi.org/10.1016/j.freeradbiomed.2016.04.010.
[25] Gao, Yanyan, Bai, Xiufeng, Zhang, Dejiu, Han, Chunsheng, Yuan, Jing, Liu, Wenbin, Cao, Xintao, Chen, Zilei, Shangguan, Fugen, Zhu, Zhenyuan, Gao, Fei, Qin, Yan. Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2016, 23(5): 441-449, https://www.webofscience.com/wos/woscc/full-record/WOS:000375633100016.
[26] Zhang, Dejiu, Yan, Kaige, Liu, Guangqiao, Song, Guangtao, Luo, Jiejian, Shi, Yi, Cheng, Erchao, Wu, Shan, Jiang, Taijiao, Lou, Jizhong, Gao, Ning, Qin, Yan. EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2016, 23(2): 125-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000369220800008.
[27] Zhang, Dejiu, Yan, Kaige, Liu, Guangqiao, Song, Guangtao, Luo, Jiejian, Shi, Yi, Cheng, Erchao, Wu, Shan, Jiang, Taijiao, Lou, Jizhong, Gao, Ning, Qin, Yan. EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2016, 23(2): 125-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000369220800008.
[28] Zhang, Dejiu, Yan, Kaige, Zhang, Yiwei, Liu, Guangqiao, Cao, Xintao, Song, Guangtao, Xie, Qiang, Gao, Ning, Qin, Yan. New insights into the enzymatic role of EF-G in ribosome recycling. NUCLEIC ACIDS RESEARCH[J]. 2015, 43(21): 10525-10533, https://www.webofscience.com/wos/woscc/full-record/WOS:000366410900045.
[29] Zhang, Yanqing, Mandava, Chandra Sekhar, Cao, Wei, Li, Xiaojing, Zhang, Dejiu, Li, Ningning, Zhang, Yiudao, Zhang, Xiaoxiao, Qin, Yan, Mi, Kaixia, Lei, Jianlin, Sanyal, Suparna, Gao, Ning. HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2015, 22(11): 906-913, https://www.webofscience.com/wos/woscc/full-record/WOS:000364273800014.
[30] Yamamoto, Hiroshi, Qin, Yan, Achenbach, John, Li, Chengmin, Kijek, Jaroslaw, Spahn, Christian M T, Nierhaus, Knud H. EF-G and EF4: translocation and back-translocation on the bacterial ribosome. NATURE REVIEWS MICROBIOLOGYnull. 2014, 12(2): 89-100, https://www.webofscience.com/wos/woscc/full-record/WOS:000330502200009.
[31] 王大成, 秦文明, 李娜, 姚德强, 叶盛, 张荣光, 朱平, 施蕴渝, 施一公, 柳振峰, 张凯, 朱平, 杨娜, 许瑞明, 秦燕, 王艳丽, 江涛, 李雪梅, 王祥喜, 高福, 施一, 刘迎芳, 邵峰, 吴蓓丽. 结构生物学研究在中国. 生物化学与生物物理进展. 2014, 944-971, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFD2014&filename=SHSW201410006&v=Mjc4MDIxTHV4WVM3RGgxVDNxVHJXTTFGckNVUjdxZmIrWm1GeWpnVTd6SU5pWFllYkc0SDlYTnI0OUZZb1I4ZVg=.
[32] Yang, Fang, Li, Zhikai, Hao, Jia, Qin, Yan. EF4 knockout E-coli cells exhibit lower levels of cellular biosynthesis under acidic stress. PROTEIN & CELLnull. 2014, 5(7): 563-567, https://www.webofscience.com/wos/woscc/full-record/WOS:000339333400009.
[33] Yang, Fang, Gao, Yanyan, Li, Zhikai, Chen, Luming, Xia, Zhiping, Xu, Tao, Qin, Yan. Mitochondrial EF4 links respiratory dysfunction and cytoplasmic translation in Caenorhabditis elegans. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS[J]. 2014, 1837(10): 1674-1683, http://dx.doi.org/10.1016/j.bbabio.2014.05.353.
[34] 徐涛. Mitochondrial EF4 links respiratory dysfunction and cytoplasmic translation in Caenorhabditis elegans. Biochimica et Biophysica Acta. 2014, 1837(10): 1674-1683, [35] Liu, Guangqiao, Song, Guangtao, Zhang, Danyang, Zhang, Dejiu, Li, Zhikai, Lyu, Zhixin, Dong, Jianshu, Achenbach, John, Gong, Weimin, Zhao, Xin Sheng, Nierhaus, Knud H, Qin, Yan. EF-G catalyzes tRNA translocation by disrupting interactions between decoding center and codon-anticodon duplex. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2014, 21(9): 817-824, https://www.webofscience.com/wos/woscc/full-record/WOS:000341404200012.
[36] Liu, Guangqiao, Song, Guangtao, Zhang, Danyang, Zhang, Dejiu, Li, Zhikai, Lyu, Zhixin, Dong, Jianshu, Achenbach, John, Gong, Weimin, Zhao, Xin Sheng, Nierhaus, Knud H, Qin, Yan. EF-G catalyzes tRNA translocation by disrupting interactions between decoding center and codon-anticodon duplex. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2014, 21(9): 817-824, https://www.webofscience.com/wos/woscc/full-record/WOS:000341404200012.
[37] 李志凯, 刘光桥, 关洪斌, 秦燕. 保守GTP酶EF-G在蛋白质合成中的功能研究. 生物物理学报[J]. 2013, 29(2): 105-117, [38] Zhang, Dejiu, Qin, Yan. The paradox of elongation factor 4: highly conserved, yet of no physiological significance?. BIOCHEMICAL JOURNALnull. 2013, 452: 173-181, http://www.irgrid.ac.cn/handle/1471x/756688.
[39] 李志凯, 刘光桥, 关洪斌, 秦燕. 保守GTP酶EF-G在蛋白质合成中的功能研究. 生物物理学报[J]. 2013, 29(2): 105-117, [40] Zhang, Dejiu, Qin, Yan. The paradox of elongation factor 4: highly conserved, yet of no physiological significance?. BIOCHEMICAL JOURNALnull. 2013, 452: 173-181, http://www.irgrid.ac.cn/handle/1471x/756688.
[41] Yan Qin. Bioinformatics analysis reveals that LepA C-terminal domain is highly conserved in domain architectures and phylogenetic distribution. Science China Chemistry. 2012, [42] Zhang, Dandan, Liu, Guangqiao, Xue, Jiaying, Lou, Jizhong, Nierhaus, Knud H, Gong, Weimin, Qin, Yan. Common chaperone activity in the G-domain of trGTPase protects L11-L12 interaction on the ribosome. NUCLEIC ACIDS RESEARCH[J]. 2012, 40(21): 10851-10865, http://www.irgrid.ac.cn/handle/1471x/756741.
[43] Qiang Xie, Yanhui Wang, Jinzhong Lin, Yan Qin, Ying Wang, Wenjun Bu. Potential Key Bases of Ribosomal RNA to Kingdom-Specific Spectra of Antibiotic Susceptibility and the Possible Archaeal Origin of Eukaryotes. PLOS ONE[J]. 2012, 7(1): http://dx.doi.org/10.1371/journal.pone.0029468.
[44] 杨福愉. A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases. Nature Structural & Molecular Biology[J]. 2012, 19(4): 403-410, http://www.irgrid.ac.cn/handle/1471x/756694.
[45] 韩斌, 秦燕. LepA蛋白羧基末端结构域组成及物种分布的生物信息学分析. 中国科学:化学[J]. 2012, 42(1): 24-31, http://lib.cqvip.com/Qikan/Article/Detail?id=40791072.
[46] Wang, Xiang, Xue, Jiaying, Sun, Zhe, Qin, Yan, Gong, Weimin. Study on the chaperone properties of conserved GTPases. PROTEIN & CELL[J]. 2012, 3(1): 44-50, http://www.irgrid.ac.cn/handle/1471x/756952.
[47] Yan Qin. Bioinformatics analysis reveals that LepA C-terminal domain is highly conserved in domain architectures and phylogenetic distribution. Science China Chemistry. 2012, [48] Zhang, Dandan, Liu, Guangqiao, Xue, Jiaying, Lou, Jizhong, Nierhaus, Knud H, Gong, Weimin, Qin, Yan. Common chaperone activity in the G-domain of trGTPase protects L11-L12 interaction on the ribosome. NUCLEIC ACIDS RESEARCH[J]. 2012, 40(21): 10851-10865, http://www.irgrid.ac.cn/handle/1471x/756741.
[49] Qiang Xie, Yanhui Wang, Jinzhong Lin, Yan Qin, Ying Wang, Wenjun Bu. Potential Key Bases of Ribosomal RNA to Kingdom-Specific Spectra of Antibiotic Susceptibility and the Possible Archaeal Origin of Eukaryotes. PLOS ONE[J]. 2012, 7(1): http://dx.doi.org/10.1371/journal.pone.0029468.
[50] 杨福愉. A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases. Nature Structural & Molecular Biology[J]. 2012, 19(4): 403-410, http://www.irgrid.ac.cn/handle/1471x/756694.
[51] 韩斌, 秦燕. LepA蛋白羧基末端结构域组成及物种分布的生物信息学分析. 中国科学:化学[J]. 2012, 42(1): 24-31, http://lib.cqvip.com/Qikan/Article/Detail?id=40791072.
[52] Wang, Xiang, Xue, Jiaying, Sun, Zhe, Qin, Yan, Gong, Weimin. Study on the chaperone properties of conserved GTPases. PROTEIN & CELL[J]. 2012, 3(1): 44-50, http://www.irgrid.ac.cn/handle/1471x/756952.
[53] Yan Qin. Chaperone Activity of Conservative GTPase ObgE. Acta.Biophysica.Sinica. 2011, [54] 薛佳莹, 关洪斌, 秦燕. 保守GTP酶ObgE的分子伴侣活性研究. 生物物理学报[J]. 2011, 27(6): 500-506, http://lib.cqvip.com/Qikan/Article/Detail?id=38458378.
[55] Pech, Markus, Karim, Zhala, Yamamoto, Hiroshi, Kitakawa, Madoka, Qin, Yan, Nierhaus, Knud H. Elongation factor 4 (EF4/LepA) accelerates protein synthesis at increased Mg2+ concentrations. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2011, 108(8): 3199-3203, https://www.webofscience.com/wos/woscc/full-record/WOS:000287580400027.
[56] Xie, Qiang, Lin, Jinzhong, Qin, Yan, Zhou, Jianfu, Bu, Wenjun. Structural diversity of eukaryotic 18S rRNA and its impact on alignment and phylogenetic reconstruction. PROTEIN & CELL[J]. 2011, 2(2): 161-170, http://dx.doi.org/10.1007/s13238-011-1017-2.
[57] Yan Qin. Chaperone Activity of Conservative GTPase ObgE. Acta.Biophysica.Sinica. 2011, [58] 薛佳莹, 关洪斌, 秦燕. 保守GTP酶ObgE的分子伴侣活性研究. 生物物理学报[J]. 2011, 27(6): 500-506, http://lib.cqvip.com/Qikan/Article/Detail?id=38458378.
[59] Pech, Markus, Karim, Zhala, Yamamoto, Hiroshi, Kitakawa, Madoka, Qin, Yan, Nierhaus, Knud H. Elongation factor 4 (EF4/LepA) accelerates protein synthesis at increased Mg2+ concentrations. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2011, 108(8): 3199-3203, https://www.webofscience.com/wos/woscc/full-record/WOS:000287580400027.
[60] Xie, Qiang, Lin, Jinzhong, Qin, Yan, Zhou, Jianfu, Bu, Wenjun. Structural diversity of eukaryotic 18S rRNA and its impact on alignment and phylogenetic reconstruction. PROTEIN & CELL[J]. 2011, 2(2): 161-170, http://dx.doi.org/10.1007/s13238-011-1017-2.
[61] XIN Liang, REN Jie, XIANG JunFeng, YAN Qin, XIE Yi, WANG KongJiang, LAI PingAn, BAI YaDuo. 6-Membered ring intermediates in polymerization of N-carboxyanhydride-L-a-arginine in H_2O. Science in China. Series B: Chemistry[J]. 2009, 52(8): 1220-1226, [62] Xin Liang, Ren Jie, Xiang JunFeng, Yan Qin, Xie Yi, Wang KongJiang, Lai PingAn, Bai YaDuo. 6-Membered ring intermediates in polymerization of N-carboxyanhydride-L-alpha-arginine in H2O. SCIENCE IN CHINA SERIES B-CHEMISTRY[J]. 2009, 52(8): 1220-1226, http://www.irgrid.ac.cn/handle/1471x/757818.
[63] Xie, Qiang, Tian, Xiaoxuan, Qin, Yan, Bu, Wenjun. Phylogenetic comparison of local length plasticity of the small subunit of nuclear rDNAs among all Hexapoda orders and the impact of hyper-length-variation on alignment. MOLECULAR PHYLOGENETICS AND EVOLUTION[J]. 2009, 50(2): 310-316, http://dx.doi.org/10.1016/j.ympev.2008.10.025.
[64] XIN Liang, REN Jie, XIANG JunFeng, YAN Qin, XIE Yi, WANG KongJiang, LAI PingAn, BAI YaDuo. 6-Membered ring intermediates in polymerization of N-carboxyanhydride-L-a-arginine in H_2O. Science in China. Series B: Chemistry[J]. 2009, 52(8): 1220-1226, [65] Xin Liang, Ren Jie, Xiang JunFeng, Yan Qin, Xie Yi, Wang KongJiang, Lai PingAn, Bai YaDuo. 6-Membered ring intermediates in polymerization of N-carboxyanhydride-L-alpha-arginine in H2O. SCIENCE IN CHINA SERIES B-CHEMISTRY[J]. 2009, 52(8): 1220-1226, http://www.irgrid.ac.cn/handle/1471x/757818.
[66] Xie, Qiang, Tian, Xiaoxuan, Qin, Yan, Bu, Wenjun. Phylogenetic comparison of local length plasticity of the small subunit of nuclear rDNAs among all Hexapoda orders and the impact of hyper-length-variation on alignment. MOLECULAR PHYLOGENETICS AND EVOLUTION[J]. 2009, 50(2): 310-316, http://dx.doi.org/10.1016/j.ympev.2008.10.025.
[67] Qin Yan. Back-translocation in protein synthesis. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2008, 35(9): 973-979, http://www.irgrid.ac.cn/handle/1471x/757634.
[68] Qin Yan. Back-translocation in protein synthesis. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2008, 35(9): 973-979, http://www.irgrid.ac.cn/handle/1471x/757634.
[69] Connell, Sean R, Topf, Maya, Qin, Yan, Wilson, Daniel N, Mielke, Thorsten, Fucini, Paola, Nierhaus, Knud H, Spahn, Christian M T. A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2008, 15(9): 910-915, https://www.webofscience.com/wos/woscc/full-record/WOS:000258928400009.
[70] Di Giacco, Viviana, Warquez, Viter, Qin, Yan, Pech, Markus, TrianaAlonso, Francisco J, Wilson, Daniel N, Nierhaus, Knud H. Shine-Dalgarno interaction prevents incorporation of noncognate amino acids at the codon following the AUG. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2008, 105(31): 10715-10720, http://www.irgrid.ac.cn/handle/1471x/757648.
[71] Qin Yan. Back-translocation in protein synthesis. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2008, 35(9): 973-979, http://www.irgrid.ac.cn/handle/1471x/757634.
[72] Qin Yan. Back-translocation in protein synthesis. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2008, 35(9): 973-979, http://www.irgrid.ac.cn/handle/1471x/757634.
[73] Connell, Sean R, Topf, Maya, Qin, Yan, Wilson, Daniel N, Mielke, Thorsten, Fucini, Paola, Nierhaus, Knud H, Spahn, Christian M T. A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2008, 15(9): 910-915, https://www.webofscience.com/wos/woscc/full-record/WOS:000258928400009.
[74] Di Giacco, Viviana, Warquez, Viter, Qin, Yan, Pech, Markus, TrianaAlonso, Francisco J, Wilson, Daniel N, Nierhaus, Knud H. Shine-Dalgarno interaction prevents incorporation of noncognate amino acids at the codon following the AUG. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2008, 105(31): 10715-10720, http://www.irgrid.ac.cn/handle/1471x/757648.
[75] Yan Qin, Norbert Polacek, Oliver Vesper, Eike Staub, Edda Einfeldt, Daniel N. Wilson, Knud H. Nierhaus. The Highly Conserved LepA Isa Ribosomal Elongation Factor that Back-Translocates the Ribosome. Cell. 2006, 127(4): 721-733, http://dx.doi.org/10.1016/j.cell.2006.09.037.
[76] Qin, Yan, Liu YiNan, Wang, KongJiang Ser. Nacl enhanced oligomerization of O-phospho-L-serine. ORIGINS OF LIFE AND EVOLUTION OF THE BIOSPHEREnull. 2006, 36(3): 321-322, https://www.webofscience.com/wos/woscc/full-record/WOS:000239899400116.
[77] Yan Qin, Norbert Polacek, Oliver Vesper, Eike Staub, Edda Einfeldt, Daniel N. Wilson, Knud H. Nierhaus. The Highly Conserved LepA Isa Ribosomal Elongation Factor that Back-Translocates the Ribosome. Cell. 2006, 127(4): 721-733, http://dx.doi.org/10.1016/j.cell.2006.09.037.
[78] Qin, Yan, Liu YiNan, Wang, KongJiang Ser. Nacl enhanced oligomerization of O-phospho-L-serine. ORIGINS OF LIFE AND EVOLUTION OF THE BIOSPHEREnull. 2006, 36(3): 321-322, https://www.webofscience.com/wos/woscc/full-record/WOS:000239899400116.

科研活动

科研项目:
1. 膜蛋白与蛋白质复合体的功能与结构研究:蛋白质翻译、折叠与降解    973项目  
2. 蛋白质翻译过程中的重要因子LepA 功能研究    国家自然科学基金委  
3. 蛋白质翻译起始和延伸过程中关键蛋白质复合物研究    中国科学院知识创新工程重要方向项目 
4 .The function of the mitochondrial translation factor in the diabetes pathogenesis       中国科学院国际合作项目 
5 .翻译延长因子EF-G的转运功能与核糖体解聚功能研究     国家自然科学基金委 
6. 蛋白质的生成、修饰与质量控制     973项目 
7. EF4(LepA)蛋白的分子伴侣活性及其与翻译过程的内在关系     国家自然科学基金项目” 
8. 线粒体功能障碍致早期心衰机制及干预策略研究    973项目 
9. 线粒体中的蛋白质翻译调控     国家自然科学基金委 
10. 线粒体翻译因子EF4蛋白在癌症和代谢疾病中的分子诊断     浙江省卫生厅 

近期参与会议:
    2015/02/22-27 高登会议之第一届翻译调控与疾病大会,美国 文图拉,大会邀请报告(Feb. 22-27th, 2015, Ventura, USA “1st Gordon Research Conference of Translation Machinery in Health & Disease”)
    2014/08/3-7 第十八届国际生物物理大会,澳大利亚 布里斯班,大会邀请报告(Aug. 3-7th, 2014, Brisbane, Australia “18th International Biophysics Congress”)
    2013/06/16-21 第十届亚洲线粒体大会,韩国 首尔,大会邀请报告(Nov. 4-6th, 2013, Seoul, Korea “10th Conference of the Asian Society of Mitochondrial Research and Medicine”)
    2013/07/9-12国际核糖体大会,美国 加州 纳帕谷,大会邀请报告 (July 9-12th 2013, California, US “Ribosomes Conference 2013”)
    2013/06/16-21 国际核酸酶与人类疾病相关酶大会,中国 香港,大会邀请报告 (Jun 16-21st 2013, HongKong “International Conference on Nucleic Acid Enzymes and Enzymes in Human Diseases”)

现指导学生

刘光桥 博士研究生 071010-生物化学与分子生物学

张德玖 博士研究生 071010-生物化学与分子生物学 

曹鑫涛   博士研究生 071010-生物化学与分子生物学 

徐本锦  博士研究生 071010-生物化学与分子生物学