基本信息
杨鹏远  男  博导  中国科学院生物物理研究所
电子邮件: Pyyang163@163.com
通信地址: 北京市朝阳区大屯路15号1号楼1411室
邮政编码:

招生信息

   
招生专业
071009-细胞生物学
100102-免疫学
100103-病原生物学
招生方向
乙肝病毒致癌机理
病毒宿主相互作用及相关肿瘤免疫应答
炎-癌转化分子机制

教育背景

1999-09--2004-07   第二军医大学   博士
1995-09--1999-07   第二军医大学   学士

工作经历

   
工作简历
2014-01~现在, 中国科学院生物物理研究所, 研究员
2009-01~2014-01,美国杜克大学医学院, 博士后/研究助理
2004-09~2008-09,第二军医大学, 教师/博士后
社会兼职
2021-04-10-2025-04-10,中国抗癌协会肿瘤分子医学专业委员会, 副主任委员
2019-12-31-2023-12-30,中国细胞生物学会细胞工程与转基因生物分会, 副会长
2019-08-01-2023-12-01,中国细胞生物学学会青年委员会, 委员
2016-10-10-2019-12-31,中国细胞生物学会细胞工程与转基因生物分会, 委员

教授课程

科研论文写作
学术道德与学术写作规范
学术道德与学术写作规范-分论-2班
医学免疫学
《感染与免疫前沿》

专利与奖励

   
奖励信息
(1) 中国科学院大学生命科学学院精品课程, 研究所(学校), 2019
专利成果
[1] 杨鹏远, 高雅楠, 游茂军. CCR4的N端重组蛋白及其用途. CN: CN108250290A, 2018-07-06.

[2] 杨鹏远, 高雅楠, 杜成志. 索拉菲尼联合CCR4拮抗剂在抑制癌生长及转移中的应用. CN: CN106421796A, 2017-02-22.

[3] 杨鹏远. CCR4拮抗剂在抑制癌生长及转移中的应用. CN: CN104622874A, 2015-05-20.

出版信息

   
发表论文
[1] Jiang, Shaodong, Wang, Xin, Chen, Kaili, Yang, Pengyuan. Establishment of an inducible cell line for Hepatitis B virus genotype C2 and its pharmacological responses to interferons. PHARMACOLOGICAL RESEARCH[J]. 2022, 178: http://dx.doi.org/10.1016/j.phrs.2022.106142.
[2] Yanan Gao, Maojun You, Junliang Fu, Meijie Tian, Xinyue Zhong, Chengzhi Du, Zhixian Hong, Zhenyu Zhu, Junliang Liu, Geoffrey J Markowitz, FuSheng Wang, Pengyuan Yang. Intratumoral stem-like CCR4+ regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B. Journal of Hepatology[J]. 2022, 76(1): 148-159, https://doi.org/10.1016/j.jhep.2021.08.029.
[3] Jiang, Shaodong, Wang, Xin, Chen, Kaili, Yang, Pengyuan. Establishment of an inducible cell line for Hepatitis B virus genotype C2 and its pharmacological responses to interferons. PHARMACOLOGICAL RESEARCH[J]. 2022, 178: http://dx.doi.org/10.1016/j.phrs.2022.106142.
[4] Yanan Gao, Maojun You, Junliang Fu, Meijie Tian, Xinyue Zhong, Chengzhi Du, Zhixian Hong, Zhenyu Zhu, Junliang Liu, Geoffrey J Markowitz, FuSheng Wang, Pengyuan Yang. Intratumoral stem-like CCR4+ regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B. Journal of Hepatology[J]. 2022, 76(1): 148-159, https://doi.org/10.1016/j.jhep.2021.08.029.
[5] You, Maojun, Chen, Liang, Zhang, Dawei, Zhao, Peng, Chen, Zhu, Qin, EnQiang, Gao, Yanan, Davis, Mark M, Yang, Pengyuan. Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19. NATURE CELL BIOLOGY[J]. 2021, 23(6): 620-+, http://dx.doi.org/10.1038/s41556-021-00690-1.
[6] Weinan Qiu, Qingyang Zhang, Rui Zhang, Yangxu Lu, Xin Wang, Huabin Tian, Ying Yang, Zijuan Gu, Yanan Gao, Xin Yang, Guanshen Cui, Baofa Sun, Yanan Peng, Hongyu Deng, Hua Peng, Angang Yang, YunGui Yang, Pengyuan Yang. N-6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA. NATURE COMMUNICATIONS[J]. 2021, 12(1): https://doaj.org/article/e3ca47ef6654412d86d5ab34d1d96bcf.
[7] Zhang, Changlu, Gao, Yanan, Du, Chengzhi, Markowitz, Geoffrey J, Fu, Jing, Zhang, Zhenxing, Liu, Chunliang, Qin, Wenhao, Wang, Hongyang, Wang, Fan, Yang, Pengyuan. Hepatitis B-Induced IL8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation. CANCER RESEARCH[J]. 2021, 81(9): 2386-2398, http://dx.doi.org/10.1158/0008-5472.CAN-20-3453.
[8] You, Maojun, Chen, Liang, Zhang, Dawei, Zhao, Peng, Chen, Zhu, Qin, EnQiang, Gao, Yanan, Davis, Mark M, Yang, Pengyuan. Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19. NATURE CELL BIOLOGY[J]. 2021, 23(6): 620-+, http://dx.doi.org/10.1038/s41556-021-00690-1.
[9] Weinan Qiu, Qingyang Zhang, Rui Zhang, Yangxu Lu, Xin Wang, Huabin Tian, Ying Yang, Zijuan Gu, Yanan Gao, Xin Yang, Guanshen Cui, Baofa Sun, Yanan Peng, Hongyu Deng, Hua Peng, Angang Yang, YunGui Yang, Pengyuan Yang. N-6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA. NATURE COMMUNICATIONS[J]. 2021, 12(1): https://doaj.org/article/e3ca47ef6654412d86d5ab34d1d96bcf.
[10] Zhang, Changlu, Gao, Yanan, Du, Chengzhi, Markowitz, Geoffrey J, Fu, Jing, Zhang, Zhenxing, Liu, Chunliang, Qin, Wenhao, Wang, Hongyang, Wang, Fan, Yang, Pengyuan. Hepatitis B-Induced IL8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation. CANCER RESEARCH[J]. 2021, 81(9): 2386-2398, http://dx.doi.org/10.1158/0008-5472.CAN-20-3453.
[11] Yang, Bo, Li, Boyuan, Jia, Liyang, Jiang, Yongpeng, Wang, Xin, Jiang, Shaodong, Du, Shunda, Ji, Xiong, Yang, Pengyuan. 3D landscape of Hepatitis B virus interactions with human chromatins. CELL DISCOVERY[J]. 2020, 6(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000603655400001.
[12] Qiu, Weinan, Wang, Bin, Gao, Yanan, Tian, Yuan, Tian, Meijie, Chen, Yuanying, Xu, Li, Yao, TsoPang, Li, Peng, Yang, Pengyuan. Targeting Histone Deacetylase 6 Reprograms Interleukin-17-Producing Helper T Cell Pathogenicity and Facilitates Immunotherapies for Hepatocellular Carcinoma. HEPATOLOGY[J]. 2020, 71(6): 1967-1987, https://www.webofscience.com/wos/woscc/full-record/WOS:000513200500001.
[13] Jia, Liyang, Gao, Yanan, He, Yaowu, Hooper, John D, Yang, Pengyuan. HBV induced hepatocellular carcinoma and related potential immunotherapy. PHARMACOLOGICAL RESEARCHnull. 2020, 159: http://dx.doi.org/10.1016/j.phrs.2020.104992.
[14] Gao, Yanan, Fan, Xing, Li, Nan, Du, Chengzhi, Yang, Bin, Qin, Wenhao, Fu, Jing, Markowitz, Geoffrey J, Wang, Hongyang, Ma, Jianli, Cheng, Shuqun, Yang, Pengyuan. CCL22 signaling contributes to sorafenib resistance in hepatitis B virus-associated hepatocellular carcinoma. PHARMACOLOGICAL RESEARCH[J]. 2020, 157: http://dx.doi.org/10.1016/j.phrs.2020.104800.
[15] Yang, Bo, Li, Boyuan, Jia, Liyang, Jiang, Yongpeng, Wang, Xin, Jiang, Shaodong, Du, Shunda, Ji, Xiong, Yang, Pengyuan. 3D landscape of Hepatitis B virus interactions with human chromatins. CELL DISCOVERY[J]. 2020, 6(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000603655400001.
[16] Qiu, Weinan, Wang, Bin, Gao, Yanan, Tian, Yuan, Tian, Meijie, Chen, Yuanying, Xu, Li, Yao, TsoPang, Li, Peng, Yang, Pengyuan. Targeting Histone Deacetylase 6 Reprograms Interleukin-17-Producing Helper T Cell Pathogenicity and Facilitates Immunotherapies for Hepatocellular Carcinoma. HEPATOLOGY[J]. 2020, 71(6): 1967-1987, https://www.webofscience.com/wos/woscc/full-record/WOS:000513200500001.
[17] Jia, Liyang, Gao, Yanan, He, Yaowu, Hooper, John D, Yang, Pengyuan. HBV induced hepatocellular carcinoma and related potential immunotherapy. PHARMACOLOGICAL RESEARCHnull. 2020, 159: http://dx.doi.org/10.1016/j.phrs.2020.104992.
[18] Gao, Yanan, Fan, Xing, Li, Nan, Du, Chengzhi, Yang, Bin, Qin, Wenhao, Fu, Jing, Markowitz, Geoffrey J, Wang, Hongyang, Ma, Jianli, Cheng, Shuqun, Yang, Pengyuan. CCL22 signaling contributes to sorafenib resistance in hepatitis B virus-associated hepatocellular carcinoma. PHARMACOLOGICAL RESEARCH[J]. 2020, 157: http://dx.doi.org/10.1016/j.phrs.2020.104800.
[19] Hanyong Sun, Weiqin Yang, Yuan Tian, Xuezhen Zeng, Jingying Zhou, Myth T S Mok, Wenshu Tang, Yu Feng, Liangliang Xu, Anthony W H Chan, Joanna H Tong, YueSun Cheung, Paul B S Lai, Hector K S Wang, ShunWa Tsang, KingLau Chow, Mengying Hu, Rihe Liu, Leaf Huang, Bing Yang, Pengyuan Yang, KaFai To, Joseph J Y Sung, Grace L H Wong, Vincent W S Wong, Alfred S L Cheng. An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/76c109e42ac94ff38c34806651e073fe.
[20] Hanyong Sun, Weiqin Yang, Yuan Tian, Xuezhen Zeng, Jingying Zhou, Myth T S Mok, Wenshu Tang, Yu Feng, Liangliang Xu, Anthony W H Chan, Joanna H Tong, YueSun Cheung, Paul B S Lai, Hector K S Wang, ShunWa Tsang, KingLau Chow, Mengying Hu, Rihe Liu, Leaf Huang, Bing Yang, Pengyuan Yang, KaFai To, Joseph J Y Sung, Grace L H Wong, Vincent W S Wong, Alfred S L Cheng. An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/76c109e42ac94ff38c34806651e073fe.
[21] Tian, Yuan, Mok, Myth T S, Yang, Pengyuan, Cheng, Alfred S L. Epigenetic Activation of Wnt/beta-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis. CANCERSnull. 2016, 8(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000396890300005.
[22] Liu, Ying, Jiang, Shu, Yang, PengYuan, Zhang, YueFan, Li, TieJun, Rui, YaoCheng. EF1A1/HSC70 Cooperatively Suppress Brain Endothelial Cell Apoptosis via Regulating JNK Activity. CNS NEUROSCIENCE & THERAPEUTICS[J]. 2016, 22(10): 836-844, https://www.webofscience.com/wos/woscc/full-record/WOS:000383628000004.
[23] Tian, Yuan, Mok, Myth T S, Yang, Pengyuan, Cheng, Alfred S L. Epigenetic Activation of Wnt/beta-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis. CANCERSnull. 2016, 8(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000396890300005.
[24] Liu, Ying, Jiang, Shu, Yang, PengYuan, Zhang, YueFan, Li, TieJun, Rui, YaoCheng. EF1A1/HSC70 Cooperatively Suppress Brain Endothelial Cell Apoptosis via Regulating JNK Activity. CNS NEUROSCIENCE & THERAPEUTICS[J]. 2016, 22(10): 836-844, https://www.webofscience.com/wos/woscc/full-record/WOS:000383628000004.
[25] Alexander, Peter B, Yuan, Lifeng, Yang, Pengyuan, Sun, Tao, Chen, Rui, Xiang, Handan, Chen, Jiekai, Wu, Haoyu, Radiloff, Daniel R, Wang, XiaoFan. EGF promotes mammalian cell growth by suppressing cellular senescence. CELL RESEARCH. 2015, 25(1): 135-138, http://ir.gibh.ac.cn/handle/344009/617.
[26] 曹雪涛, 安华章, 于益芝, 刘星光, 徐胜, 刘书逊, 韩超峰, 蒋应明, 杨鹏远, 侯晋. 天然免疫识别及其调控的分子机制研究. 中国科技奖励[J]. 2015, 66-66, http://lib.cqvip.com/Qikan/Article/Detail?id=664249925.
[27] Alexander, Peter B, Yuan, Lifeng, Yang, Pengyuan, Sun, Tao, Chen, Rui, Xiang, Handan, Chen, Jiekai, Wu, Haoyu, Radiloff, Daniel R, Wang, XiaoFan. EGF promotes mammalian cell growth by suppressing cellular senescence. CELL RESEARCH. 2015, 25(1): 135-138, http://ir.gibh.ac.cn/handle/344009/617.
[28] 曹雪涛, 安华章, 于益芝, 刘星光, 徐胜, 刘书逊, 韩超峰, 蒋应明, 杨鹏远, 侯晋. 天然免疫识别及其调控的分子机制研究. 中国科技奖励[J]. 2015, 66-66, http://lib.cqvip.com/Qikan/Article/Detail?id=664249925.
[29] Zhang, Yun, Yang, Pengyuan, Wang, XiaoFan. Microenvironmental regulation of cancer metastasis by miRNAs. TRENDS IN CELL BIOLOGYnull. 2014, 24(3): 153-160, http://dx.doi.org/10.1016/j.tcb.2013.09.007.
[30] Yang, Pengyuan, Markowitz, Geoffrey J, Wang, XiaoFan. The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma. NATIONAL SCIENCE REVIEW[J]. 2014, 1(3): 396-412, http://lib.cqvip.com/Qikan/Article/Detail?id=78658382504849524851484956.
[31] Zhang, Yun, Yang, Pengyuan, Wang, XiaoFan. Microenvironmental regulation of cancer metastasis by miRNAs. TRENDS IN CELL BIOLOGYnull. 2014, 24(3): 153-160, http://dx.doi.org/10.1016/j.tcb.2013.09.007.
[32] Yang, Pengyuan, Markowitz, Geoffrey J, Wang, XiaoFan. The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma. NATIONAL SCIENCE REVIEW[J]. 2014, 1(3): 396-412, http://lib.cqvip.com/Qikan/Article/Detail?id=78658382504849524851484956.
[33] Zhang, Yun, Yang, Pengyuan, Sun, Tao, Li, Dong, Xu, Xin, Rui, Yaocheng, Li, Chaoran, Chong, Mengyang, Ibrahim, Toni, Mercatali, Laura, Amadori, Dino, Lu, Xincheng, Xie, Dong, Li, QiJing, Wang, XiaoFan. miR-126 and miR-126*repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. NATURE CELL BIOLOGY[J]. 2013, 15(3): 284-294, https://www.webofscience.com/wos/woscc/full-record/WOS:000315844900009.
[34] Curtis, Valerie F, Wang, Hui, Yang, Pengyuan, McLendon, Roger E, Li, Xiaohan, Zhou, QunYong, Wang, XiaoFan. A PK2/Bv8/PROK2 Antagonist Suppresses Tumorigenic Processes by Inhibiting Angiogenesis in Glioma and Blocking Myeloid Cell Infiltration in Pancreatic Cancer. PLOS ONE[J]. 2013, 8(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000314021500143.
[35] Zhang, Yun, Yang, Pengyuan, Sun, Tao, Li, Dong, Xu, Xin, Rui, Yaocheng, Li, Chaoran, Chong, Mengyang, Ibrahim, Toni, Mercatali, Laura, Amadori, Dino, Lu, Xincheng, Xie, Dong, Li, QiJing, Wang, XiaoFan. miR-126 and miR-126*repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. NATURE CELL BIOLOGY[J]. 2013, 15(3): 284-294, https://www.webofscience.com/wos/woscc/full-record/WOS:000315844900009.
[36] Curtis, Valerie F, Wang, Hui, Yang, Pengyuan, McLendon, Roger E, Li, Xiaohan, Zhou, QunYong, Wang, XiaoFan. A PK2/Bv8/PROK2 Antagonist Suppresses Tumorigenic Processes by Inhibiting Angiogenesis in Glioma and Blocking Myeloid Cell Infiltration in Pancreatic Cancer. PLOS ONE[J]. 2013, 8(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000314021500143.
[37] Yang Pengyuan, Li Qi-Jing, Feng Yuxiong, Zhang Yun, Markowitz Geoffrey J., Ning Shanglei, Deng Yuezhen, Zhao Jiangsha, Jiang Shan, Yuan Yunfei, Wang Hong-Yang, Cheng Shu-Qun, Xie Dong, Wang Xiao-Fan. TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma. Cancer Cell. 2012, 22(3): 291-303, http://dx.doi.org/10.1016/j.ccr.2012.07.023.
[38] Yang Pengyuan, Li Qi-Jing, Feng Yuxiong, Zhang Yun, Markowitz Geoffrey J., Ning Shanglei, Deng Yuezhen, Zhao Jiangsha, Jiang Shan, Yuan Yunfei, Wang Hong-Yang, Cheng Shu-Qun, Xie Dong, Wang Xiao-Fan. TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma. Cancer Cell. 2012, 22(3): 291-303, http://dx.doi.org/10.1016/j.ccr.2012.07.023.

科研活动

   
科研项目
( 1 ) 肝癌肿瘤微环境, 主持, 国家级, 2016-06--2018-12
( 2 ) 脑血管稳态调节基因DCN分子机制研究, 主持, 国家级, 2015-01--2017-12
( 3 ) 天然免疫抗病毒效应机理与病毒逃逸机制研究, 主持, 部委级, 2014-01--2016-12
( 4 ) 间质细胞重编程癌微环境机制, 主持, 国家级, 2015-01--2019-12
( 5 ) HBV阳性肝癌中索拉菲尼耐药治疗的T细胞免疫调节新靶标CCR4受体拮抗剂的发现研究, 主持, 部委级, 2017-01--2018-12
( 6 ) 乙肝阳性肝癌活化CXCL8/CXCR1促使肿瘤血管转移的功能机制研究, 主持, 国家级, 2017-01--2020-12
参与会议
(1)The Hepatitis B initialed liver carcinogenesis and immune therapy strategy   第14届全国免疫学大会   2021-10-22
(2)The Hepatitis B initialed liver carcinogenesis    2020肿瘤免疫与生物治疗年会   2020-11-07
(3)内质网蛋白Nogo-B在肝脏炎-癌转化中功能研究   第十届北京市肿瘤学术沙龙会议   杨鹏远   2019-06-09
(4)肝癌铁死亡机制研究   中国抗癌协会肿瘤营养专业委员会肿瘤精准营养学年会   杨鹏远   2019-04-06
(5)HBV阳性肝癌微环境研究   中国肿瘤学大会   杨鹏远   2018-08-17
(6)The hepatitis B virus-associated tumor microenvironment and T cell-mediated targets   第一届全国肿瘤细胞生物学年会   杨鹏远   2018-08-01

指导学生

已指导学生

祝磊  博士研究生  071009-细胞生物学  

于沥博  硕士研究生  071009-细胞生物学  

张振兴  博士研究生  071009-细胞生物学  

杨博  博士研究生  071009-细胞生物学  

姜韶东  博士研究生  071009-细胞生物学  

马杰  硕士研究生  071010-生物化学与分子生物学  

杨彬  博士研究生  071009-细胞生物学  

邱伟楠  博士研究生  071009-细胞生物学  

游茂军  博士研究生  071009-细胞生物学  

杜成志  博士研究生  071011-生物物理学  

现指导学生

刘俊良  博士研究生  071010-生物化学与分子生物学  

黄学涛  博士研究生  071009-细胞生物学  

廖咨冰  博士研究生  071009-细胞生物学  

路杨旭  博士研究生  071009-细胞生物学  

张亦茗  硕士研究生  0710J3-生物信息学  

刘兰兰  博士研究生  071009-细胞生物学  

陈微  博士研究生  071009-细胞生物学  

贾力扬  博士研究生  071009-细胞生物学  

张锡友  硕士研究生  071009-细胞生物学  

谢润泽  硕士研究生  071009-细胞生物学  

马保丽  硕士研究生  071009-细胞生物学