蔡新霞,女,研究员(二级),博导,岗位教授 

中国科学院空天信息创新研究院 传感技术国家重点实验室

专业:微电子学与固体电子学、生物电子学

电邮:xxcai@mail.ie.ac.cn;电话:010-58887193

地址:北京市中关村北一条9号科电大厦1109,100190

基金委创新研究群体学术带头人(微纳传感技术)(2022-2026)

获国家杰出青年科学基金资助(敏感电子学(2012-2016)

重大科学研究计划项目首席科学家(基于纳米技术的神经信息检测相关基础研究)(2011)

简历


蔡新霞,中国科学院空天信息创新研究院传感技术国家重点实验室二级研究员,国家杰出青年科学基金获得者,“微纳传感技术”创新研究群体学术带头人、国家重大科学研究计划项目首席科学家、生物交叉装备应用专家组成员,入选国家百千万人才和北京百名领军人才工程(电子信息类),任中国电子学会会士、中国仪器仪表学会传感器分会委员委员、“十四五”国家重点研发计划信息领域“微纳电子技术”专项总体专家组成员、2030脑科学“技术平台”管理专家组成员。

蔡新霞长期从事脑机接口神经微电极阵列等微纳生物传感器与系统基础技术研究工作,主持交叉重大项目“睡眠-觉醒脑神经电活动高分辨感测与电刺激方法”等国家重大科技任务5项。提出双模神经信号同步检测方法,攻克了神经微电极阵列制备工艺等关键技术,实现了脑机接口核心微器件技术自主研发与多领域应用。获国家技术发明二等奖1项(排名1)、全国创新争先奖状、中国电子学会技术发明一等奖1项(排名1),是国务院政府特殊津贴专家(自然科学)、中央和国家机关三八红旗手、中科院三八红旗手,多次获中国科学院优秀导师等荣誉称号。在Nature子刊和仪器仪表传感领域顶刊等上发表高水平学术论文280篇,引用4150次,合著中英文专著10部;重要学术会议邀请报告77篇,部分专利技术实现转化应用。



研究领域:脑机接口等微纳生物传感器与系统
1、高时空分辨神经微电极阵列
2、神经信息检测调控仪器
3、离体脑机接口与生物神经网络计算
教育简历
  • 1998-08--2001-11 英国格拉斯哥大学电子与电气工程系生物电子学博 士


  • 1988-09--1991-07 中国科学院半导体所 工学硕士


  • 1984-09--1988-07 北京理工大学电子工程系 工学学士
工作简历
  • 1991.08~1996.12 中国科学院电子学研究所 研实、助研


  • 1995.04~1995.07 日本东京工业大学访问学者


  • 1997.01~2002.03 中国科学院电子学研究所 副研


  • 2002.04~2011.06 中国科学院电子学研究所 研究员


  • 2011.07~至今 中国科学院空天信息创新研究院(原电子学研究所)专业技术岗位二级研究员


  • 2016.04~至今中国科学院空天信息创新研究院(原电子学研究所)特聘核心骨干研究员
奖励与荣誉

(1) 中国电子学会技术发明奖“高时空分辨双模神经微电极阵列关键技术与应用”, 一等奖, 其他, 2023

(2) 全国创新争先奖状, , 国家级, 2023

(3) 中央和国家机关三八红旗手, , 部委级, 2023

(4) “微纳传感技术”创新研究群体学术带头人, , 国家级, 2022

(5) 科技北京领军 人才工程(电子信息领域科技创新类), , 部委级, 2015

(6) 国家百千万人才工程“有突出贡献中青年专家”, 国家级, 2014

(7) 国家技术发明奖“基于生物敏感膜的便携式传感器及关键技术及应用”, 二等奖, 国家级, 2013

(8) 国务院颁发政府特殊津贴, 国家级, 2013

(9) 国家杰出青年科学基金“敏感电子学”, , 国家级, 2012

(10) 被科技部聘为纳米研究重大科学研究计划项目首席科学家, 国家级, 2011

教授课程

本科生毕业设计(电子信息工程)
前沿电子学研究
综合电子学研究
科技前沿系列讲座:脑机接口传感器与智能系统
科学前沿进展名家系列讲座IV第292讲:高时空分辨脑机接口
生物电子学
科学前沿进展名家系列讲座IV
科研实践Ⅱ
科研实践Ⅰ
生物芯片技术前沿

主持国家重大任务

重大任务名称

任务类型

岗位

备注

1、睡眠-觉醒脑神经电活动高分辨感测与电刺激方法研究

国家自然科学基金交叉重大项目

项目负责人

2023.012027.12

2、微纳传感技术创新研究群体

国家自然科学基金创新研究群体项目

项目负责人

2022.01—2026.12

3、高时空分辨微纳电极阵列与神经信息光电调控检测系统

国家重点研发计划项目

项目负责人

2017.072022.06

4、多层次调控与高通量神经信号同步检测仪器

国家重大科研仪器研制项目

项目负责人

2016.012020.12

5、基于纳米技术的神经信息检测相关基础研究

国家重大科学研究计划项目

首席科学家

2011.012015.08


发表论文

详见Researchgate:

https://www.researchgate.net/profile/Xinxia-Cai/publications

 

代表性论文 *通讯作者):


1) Shiya Lv, Fan Mo, Zhaojie Xu, Yu Wang, Yaoyao Liu, Meiqi Han, Yiming Duan, Luyi Jing, Fanli Kong, Qianli Jia. Ming Li, Wei Xu, Peiyao Jiao, Mixia Wang, Juntao Liu, Jinping Luo, Junbo Wang, Zhongwei Fan, Yilin Song*, Yirong Wu*,  Xinxia Cai*. Integrated dopamine sensing and 40 Hz hippocampal stimulation improves cognitive performance in Alzheimer’s mouse models, Nature Communications2025, 16:5948. https://doi.org/10.1038/s41467-025-60903-1(SCI, IF=15.72, TOP) 


2) Yu Wang, Meiqi Han, Zhao,jie Xu, Shiya Lv, Gucheng Yang, Fan Mo, Luyi Jing, Qianli Jia, Yiming Duan, Wei Xu, Peiyao Jiao, Yaoyao Liu, Jin Shan, Ming Li, Mixia Wang, Jinping Luo, Yilin Song, Juntao Liu*, Yirong Wu*, Xinxia Cai*. Chronic implantable flexible serpentine probe reveals impaired spatial coding of place cells in epilepsy. National Science Review.  202412(2):nwae402. doi:10.1093/nsr/nwae402. eCollection 2025 Feb. (SCI, IF=16.3, TOP) 

3Kui Zhang, Yu Deng, Yaoyao Liu, Jinping Luo, Andrew Glidle, Jonathan M. Cooper, Shihong Xu, Yan Yang, Shiya Lv, Zhaojie Xu, Yirong Wu, Longzhe Sha, Qi Xu*, Huabing Yin*, and Xinxia Cai*Investigating Communication Dynamics in Neuronal Network using 3D Gold Microelectrode Arrays. ACS Nano, 2024, 18 (26):17162-17174. (SCI, IF=15.1, TOP)

4Yu Wang, Meiqi Han, Luyi Jing, Qianli Jia, Shiya Lv, Zhaojie Xu*, Juntao Liu*, Xinxia Cai*. Enhanced neural activity detection with microelectrode arrays modified by drug-loaded calcium alginate/chitosan hydrogel. Biosensors & Bioelectronics, 2025, 267, 116837. (仪器仪表与传感领域顶刊SCI, IF=12.5, TOP 

5Chengling Wu, Jingyu Xie, Qingxin Yao, Yilin Song, Gucheng Yang, Jie Zhao, Ruijia Zhang, Ting Wang, Xingyu Jiang, Xinxia Cai*, Yuan Gao*, Intrahippocampal Supramolecular Assemblies Directed Bioorthogonal Liberation of Neurotransmitters to Suppress Seizures in Freely Moving Mice, Advanced Material, 2024, 23143102024 https://doi.org/10.1002/adma.202314310 (SCI, TOP, IF 29.4)

6Qianli Jia, Yiming Duan, Yaoyao Liu, Juntao Liu, Jinping Luo, Yilin Song, Zhaojie Xu, Kui Zhang, Jin Shan, Fan Mo, Mixia Wang*, Ying Wang*, Xinxia Cai*. PtNPs/IrOx nanocomposite-modified bidirectional microelectrode array used for deep brain stimulation and detection of electrophysiological signals in the DMH nucleus in situ under sevoflurane anesthesia. ACS Sensors. 2024, 9, 6: 2877-2887.(仪器仪表与传感领域顶刊SCI, IF=9.6, TOP 

7Yaoyao Liu, Yu Deng, Shihong Xu, Yan Yang, Kui Zhang, Junrao Liu, Zhaojie Xu, Shiya Lv, Yu Wang, Longze Sha, Ruilin Hu, Zhaojie Xu, Erwei Yin, Qi Xu*, Jinping Luo*, Xinxia Cai*. Neuromodulatory Compensation of Cortical Neural Activity on Electrodeposited Pt/Ir Modified Microelectrode Arrays for Temperature Transients. ACS Applied Materials & Interfaces. 2024, 16 (34), 44538-44548. (SCI, IF=8.3, TOP, 封面

8Jiahui Luo; Zhaojie Xu; Zhenhu Jin; Mixia Wang; Xinxia Cai*; Jiamin Chen*. Development and Comprehensive Evaluation of TMR Sensor-Based MagnetrodesACS Applied Materials Interfaces, 2024, 16(24): 31677-31. 686 (SCI, IF=8.3, TOP)

9Wei Xu, Mixia Wang, Gucheng Yang, Fan Mo, Yaoyao Liu, Jin Shan,Luyi Jing, Ming Li, Juntao Liu, Shiya Lv, Yiming Duan, Meiqi Han, Zhaojie Xu*, Yilin Song*, Xinxia Cai*. Neuronal activity in ventral tegmental area during goal-directed navigation recorded by low curvature microelectrode arrays. Microsystems & Nanoengineering. 2024, 10:145, DOI:10.1038/s41378-024-00778-2. (仪器仪表与传感领域顶刊SCI, IF=9.9, TOP 

10) Shiya Lv, Fan Mo, Zhaojie Xu, Yu Wang, Gucheng Yang, Meiqi Han, Luyi Jing, Wei Xu, Yiming Duan,Yaoyao Liu, Ming Li, Juntao Liu, Jinping Luo, Mixia Wang, Yilin Song*, Yirong Wu*, Xinxia Cai* ,Tentacle Microelectrode Arrays Uncover Soft Boundary Neurons in Hippocampal CA1,  Advanced Science 2024, 2401670. (SCI, TOP, IF= 15.1). https://doi.org/10.1002/advs.202401670

11) Shiya Lv, Enhui He, Jinping Luo, Yaoyao Liu, Wei Liang, Shihong Xu, Kui Zhang, Yan Yang, Mixia Wang, Yilin Song*, Yirong Wu*, Xinxia Cai*. Humaninduced pluripotent stem cell on micro-electrodearray facilitates neural disease modeling in vitro: a review. Advanced Science, 2023, 10, 2301828. https://doi.org/10.1002/advs.202301828. (SCI, TOP, IF 15.1)

12) Yaoyao Liu, Shihong Xu, Yan Yang, Kui Zhang, Enhui He, Wei Liang, Jinping Luo*, Yirong Wu*, Xinxia Cai*. Nanomaterial-based microelectrodes array for in-vitro bidirectional brain-computer interface: a review. Microsystems & Nanoengineering 2023, 9, 13. https://doi.org/10.1038/s41378-022-00479-8.( SCI, TOP, IF 8.0)

13) Z. Xu, F. Mo, G. Yang, P. Fan, B. Lu, W. Liang, F. Kong, L. Jing, W. Xu, J. Liu, M. Wang*, Y. Wu*, X. Cai*. Impaired spatial representations and electrophysiology in medial entorhinal cortex of the epileptic rat detected by microelectrode arrays. Research, 2023, 6, 0229. https://doi.org/10.34133/research.0229 (SCI, TOP, IF 11

14) M. Liu, J. Liu, W. Liang, B. Lu, P. Fan, Y. Song, M. Wang, Y. Wu*, X. Cai*. Recent Advances and Research Development on Microsystems and Bioeffects of Terahertz Neuromodulation. Microsystems & Nanoengineering, 20239, 143. https://doi.org/10.1038/s41378-023-00612-1 (仪器仪表与传感领域顶刊SCI, IF=8.006, TOP 

15) Fan Mo, Fanli Kong, Gucheng Yang, Zhaojie Xu, Wei Liang, Juntao Liu, Kui Zhang, Yaoyao Liu, Shiya Lv, Meiqi Han, Yu Wang, Yilin Song, Mixia Wang*, Yirong Wu*, Xinxia Cai*. Integrated threeelectrode dual-mode detection chip for place cell analysis: dopamine facilitates the role of place cells in encoding spatial locations of novel environments and rewards. ACS Sensors, 2023, 8, 12, 4765-4773. https://doi.org/10.1021/acssensors.3c01864 (仪器仪表与传感领域顶刊SCI, IF=9.6, TOP 

16) G. Yang, Y Wang, F. Mo, Xu Z, B. Lu, P. Fan, F. Kong, W. Xu, E. He, K. Zhang, J. Liu, X. Cai*. PEDOT-citrate/SIKVAV modified bioaffinity microelectrode arrays for detecting theta rhythm cells in the retrosplenial cortex of rats under sensory conflict Sensors and Actuators B: Chemical, 2024, 399, 134802. (仪器仪表与传感领域顶刊,SCI, IF=8.4,  TOP .

17) Y Liu, S Xu, Y Deng, J Luo, K Zhang, Y Yang, L Sha, R Hu, Z Xu, E Yin, Q Xu*, Y Wu*, X. Cai*,SWCNTs/PEDOT:PSS nanocomposites-modified microelectrode arrays for revealing locking relations between burst and local field potential in cultured cortical networks. Biosensors and Bioelectronics, 2024, 253: 116168. (仪器仪表与传感领域顶刊,SCI, IF=12.545,  TOP 

18) P Fan, R Zhang, G Xiao, Y Song, C Zhuang, L Yuan, F Mo, B Lu, Z Xu, Y Wang, J Luo, M Wang, W Mi, J Cao*, Q Dai*, X Cai*. Simultaneous recording of neuronal discharge and calcium activity reveals claustrum-cortex neurosynchrony under anesthesia, Fundamental Research, 2024, 2667-3258. (SCI, IF 6.2).

19) L Jing, Z Xu, P Fan, B Lu, F Mo, R Hu, W Xu, J Shan, Q Jia, Y Zhu, Y Duan, M Wang*, Y Wu*, X. Cai*. Deep brain implantable microelectrode arrays for detection and functional localization of the subthalamic nucleus in rats with Parkinson’s disease, Bio-design and Manufacturing. 2024, 1-14. (SCI, TOP, IF 7.3)

20) Jingyu Xie, Yuchuan Dai, Yu Xing, Yiding Wang, Gucheng Yang, Enhui He, Zhaojie Xu, Penghui Fan, Fan Mo, Yirong Wu, Yilin Song*, Xinxia Cai*. PtNPs/rGO-GluOx/mPD directionally electroplated dual-mode microelectrode arrays for detecting the synergistic relationship between the cortex and hippocampus of epileptic rats. ACS Sensors, 2023, 8, 1810-1818. https://pubs.acs.org/doi/10.1021/acssensors.3c00140. (仪器仪表与传感领域顶刊SCI, IF=9.6, TOP 

21) Penghui Fan, Yiding Wang, Yuchuan Dai, Luyi Jing, Wei Liang, Botao Lu, Gucheng Yang, Yilin Song*, Yirong Wu*, Xinxia Cai*. Flexible microelectrode array probe for simultaneous detection of neural discharge and dopamine in striatum of mice aversion system. Sensors and Actuators B: Chemical, 2023, 390, 133990. https://doi.org/10.1016/j.snb.2023.133990. (仪器仪表与传感领域顶刊SCI, IF=9.2, TOP 

22) Botao Lu, Penghui Fan, Ming Li, Yiding Wang, Wei Liang, Gucheng Yang, Fan Mo, Zhaojie Xu, Jin Shan, Yilin Song, Juntao Liu*, Yirong Wu*, Xinxia Cai*. Detection of neuronal defensive discharges information transmission and characteristics in the periaqueductal gray double-subregions using PtNPs/PEDOT:PSS-modified microelectrode arrays. Microsystems & Nanoengineering, 2023, 9, 70. https://doi.org/10.1038/s41378-023-00546-8.(仪器仪表与传感领域顶刊SCI, IF=8.006, TOP 

23) Yang Wang, Jinping Luo, Juntao Liu, Shuai Sun, Ying Xiong, Yuanyuan Ma, Shi Yan, Yue Yang, Huabing Yin, Xinxia Cai*Label-free microfluidic paper-based electrochemical aptasensor for ultrasensitive and simultaneous multiplexed detection of cancer biomarkersBiosensors and Bioelectronics136(2019)84~90 (仪器仪表与传感领域顶刊,SCI, IF=12.545,  TOP 

24) Yan Fan, Juntao Liu, Yang Wang, Jinping Luo, Huiren Xu, Shengwei Xu, Xinxia Cai*A wireless point-of-care testing system for the detection of neuron-specific enolase with microfluidic paper-basedanalytical devicesBiosensors & Bioelectronics95(2017)60~66 (仪器仪表与传感领域顶刊,SCI, IF=12.545,  TOP 

25) Wentao Shi, Chunxiu Liu, Yilin Song, Nansen Lin, Shuai Zhou, Xinxia Cai*An ascorbic acid amperometric sensor using over-oxidized polypyrrole and palladium nanoparticles compositesBiosensors and Bioelectronics38(2012)100~106 (仪器仪表与传感领域顶刊,SCI, IF=12.545,  TOP 

26) Song Zhang, Yilin Song, Mixia Wang, Guihua Xiao, Fei Gao, Ziyue Li, Guoxian Tao, Ping Zhuang, Feng Yue*, Piu Chan*, Xinxia Cai*Real-time simultaneous recording of electrophysiological activities and dopamine overflow in the deep brain nuclei of a nonhuman primate with Parkinson’s disease using nano-based microelectrode arraysMicrosystems & Nanoengineering, 4(2018), 170701~ 9 (仪器仪表与传感领域顶刊SCI, IF=8.006, TOP 

27) Wenjing Wei, Yilin Song, Li Wang, Song Zhang, Jinping Luo, Shengwei Xu, Xinxia Cai*An implantable microelectrode array for simultaneous L-glutamate and electrophysiological recordings in vivoMicrosystems and Nanoengineering1(2015), 1~6 (仪器仪表与传感领域顶刊SCI, IF=8.006, TOP