071010-生物化学与分子生物学

细胞内物质运输调控相关分子马达的结构与功能
囊泡转运以及自噬体形成调控相关蛋白质复合物的结构与功能

2001-09--2005-11   香港科技大学生物化学系   生物化学博士
1997-09--2001-07   复旦大学化学系   化学学士

香港科技大学生物化学系 -- 研究生

香港科技大学生物化学系 -- 博士

   

2009-08~现在, 中国科学院生物物理研究所, 研究员
2007-08~2009-08,香港科技大学生物化学系, 研究助理教授
2005-11~2007-08,香港科技大学生物化学系, 博士后研究助理

结构生物学技术
细胞的物理生物学
高等生物物理学/细胞的生物物理学
高等生物物理学
生物物理学系列讲座
结构生物学导论

   

[1] Li, Wei, Xing, Ying, Wang, Yue, Xu, Tao, Song, Eli, Feng, Wei. A non-canonical target-binding site in Munc18-1 domain 3b for assembling the Mint1-Munc18-1-syntaxin-1 complex. STRUCTURE[J]. 2023, 31(1): 68-77, http://dx.doi.org/10.1016/j.str.2022.11.002.
[2] Chai, Yongping, Li, Dong, Gong, Weibin, Ke, Jingyi, Tian, Dianzhe, Chen, Zhe, Guo, Angel, Guo, Zhengyang, Li, Wei, Feng, Wei, Ou, Guangshuo. A Plant Flavonol and Genetic Suppressors Rescues a Pathogenic Mutation Associated with Kinesin in Neurons. Proc. Natl. Acad. Sci. USA[J]. 2023, in press-, [3] Ren, Jinqi, Li, Dong, Liu, Juyuan, Liu, Hao, Yan, Xiumin, Zhu, Xueliang, Feng, Wei. Intertwined Wdr47-NTD dimer recognizes a basic-helical motif in Camsap proteins for proper central-pair microtubule formation. Cell Reports[J]. 2022, 41(6): 111589-, [4] Hao, Yang, Guo, Tao, Ren, Jinqi, Wang, Yaxin, Wang, Lei, Shi, Yawei, Feng, Wei. Characterization of a thermostable, protease-tolerant inhibitor of α-glycosidase from carrot: A potential oral additive for treatment of diabetes. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2022, 209: 1271-1279, [5] Wang, Wenjuan, Ren, Jinqi, Song, Weiye, Zhang, Yong, Feng, Wei. The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for autoinhibition. NATURE COMMUNICATIONS[J]. 2022, 13(1): 4281-, https://doaj.org/article/4fdb859652504f3c902420b4b49714bf.
[6] Chen, Feilong, Liu, Beibei, Zeng, Jianwei, Guo, Lu, Ge, Xuan, Feng, Wei, Li, DeFeng, Zhou, Hao, Long, Jiafu. Crystal Structure of the Core Module of the Yeast Paf1 Complex. JOURNAL OF MOLECULAR BIOLOGY[J]. 2022, 434(2): 167369-, http://dx.doi.org/10.1016/j.jmb.2021.167369.
[7] Cong, Dezi, Ren, Jinqi, Zhou, Yurong, Wang, Shuang, Jingjing Liang, Ding, Mei, Feng, Wei. Motor domain-mediated autoinhibition dictates axonal transport by the kinesin UNC-104/KIF1A. PLOS GENETICS[J]. 2021, 17(11): e1009940-, [8] Zhao, Yinsuo, Song, Eli, Wang, Wenjuan, Hsieh, ChungHan, Wang, Xinnan, Feng, Wei, Wang, Xiangming, Shen, Kang. Metaxins are core components of mitochondrial transport adaptor complexes. NATURE COMMUNICATIONS[J]. 2021, 12(1): 83-, http://dx.doi.org/10.1038/s41467-020-20346-2.
[9] Chen, Feilong, Liu, Beibei, Guo, Lu, Ge, Xuan, Feng, Wei, Li, De-Feng, Zhou, Hao, Long, Jiafu. Biochemical insights into Paf1 complex-induced stimulation of Rad6/Bre1-mediated H2B monoubiquitination. Proc. Natl. Acad. Sci. USA[J]. 2021, 118(33): e2025291118-, [10] Zhang, Zhe, Li, Wei, Yang, Guang, Lu, Xuefeng, Qi, Xin, Wang, Shuting, Cao, Can, Zhang, Peng, Ren, Jinqi, Zhao, Jiaxu, Zhang, Junyi, Hong, Sheng, Tan, Yan, Burchfield, James, Yu, Yang, Xu, Tao, Yao, Xuebiao, James, David, Feng, Wei, Chen, Zhengjun. CASK modulates the assembly and function of the Mint1/Munc18-1 complex to regulate insulin secretion. CELL DISCOVERY[J]. 2020, 6(1): 92-, https://doaj.org/article/7bbce9236f564a33b68af091c64d076f.
[11] Ren, Jinqi, Liang, Ruobing, Wang, Wenjuan, Zhang, Dachuan, Yu, Li, Feng, Wei. Multi-site-mediated entwining of the linear WIR-motif around WIPI beta-propellers for autophagy. NATURE COMMUNICATIONS[J]. 2020, 11(1): 2702-, https://www.webofscience.com/wos/woscc/full-record/WOS:000542982400014.
[12] Liang, Ruobing, Ren, Jinqi, Zhang, Yong, Feng, Wei. Structural Conservation of the Two Phosphoinositide-Binding Sites in WIPI Proteins. JOURNAL OF MOLECULAR BIOLOGY[J]. 2019, 431(7): 1494-1505, http://dx.doi.org/10.1016/j.jmb.2019.02.019.
[13] Xu, Yang, Ren, Jinqi, He, Xiaolong, Chen, Han, Wei, Taotao, Feng, Wei. YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. AUTOPHAGY[J]. 2019, 15(6): 1017-1030, [14] Xu, Yang, Li, Wei, Ke, Huimin, Feng, Wei. Structural conservation of the autoinhibitory domain in SUN proteins. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2018, 496(4): 1337-1343, http://dx.doi.org/10.1016/j.bbrc.2018.02.015.
[15] Ren, Jinqi, Zhang, Yong, Wang, Shuang, Huo, Lin, Lou, Jizhong, Feng, Wei. Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement. JOURNAL OF MOLECULAR BIOLOGY[J]. 2018, 430(14): 2030-2041, http://dx.doi.org/10.1016/j.jmb.2018.05.010.
[16] Ren, Jinqi, Wang, Shuang, Chen, Han, Wang, Wenjuan, Huo, Lin, Feng, Wei. Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(51): E11933-E11942, https://www.webofscience.com/wos/woscc/full-record/WOS:000453529800009.
[17] Niwa Shinsuke, Tao Li, Lu Sharon Y., Liew Gerald M., Feng Wei, Nachury Maxence V., Shen Kang. BORC regulates the axonal transport of synaptic vesicle precursors by activating ARL-8. CURRENT BIOLOGY : CB[J]. 2017, 27(17): 2569-2578.e4, http://dx.doi.org/10.1016/j.cub.2017.07.013.
[18] Ren, Jinqi, Huo, Lin, Wang, Wenjuan, Zhang, Yong, Li, Wei, Lou, Jizhong, Xu, Tao, Feng, Wei. Structural Correlation of the Neck Coil with the Coiled-coil (CC1)-Forkhead-associated (FHA) Tandem for Active Kinesin-3 KIF13A. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2016, 291(7): 3581-3594, http://dx.doi.org/10.1074/jbc.M115.689091.
[19] Du, Wen, Zhou, Maoge, Zhao, Wei, Cheng, Dongwan, Wang, Lifen, Lu, Jingze, Song, Eli, Feng, Wei, Xue, Yanhong, Xu, Pingyong, Xu, Tao. HID-1 is required for homotypic fusion of immature secretory granules during maturation. ELIFE[J]. 2016, 5: 18134-18155, https://doaj.org/article/e6ece92f93ed466587d4b27667c15da4.
[20] Nie, Si, Ke, Huimin, Gao, Feng, Ren, Jinqi, Wang, Mingzhu, Huo, Lin, Gong, Weimin, Feng, Wei. Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators. STRUCTURE[J]. 2016, 24(1): 80-91, http://dx.doi.org/10.1016/j.str.2015.10.024.
[21] Yi, Fengshuang, Kong, Ruirui, Ren, Jinqi, Zhu, Li, Lou, Jizhong, Wu, Jane Y, Feng, Wei. Noncanonical Myo9b-RhoGAP Accelerates RhoA GTP Hydrolysis by a Dual-Arginine-Finger Mechanism. JOURNAL OF MOLECULAR BIOLOGY[J]. 2016, 428(15): 3043-3057, http://www.corc.org.cn/handle/1471x/2374370.
[22] Kong, Ruirui, Yi, Fengshuang, Wen, Pushuai, Liu, Jianghong, Chen, Xiaoping, Ren, Jinqi, Li, Xiaofei, Shang, Yulong, Nie, Yongzhan, Wu, Kaichun, Fan, Daiming, Zhu, Li, Feng, Wei, Wu, Jane Y. Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression. JOURNAL OF CLINICAL INVESTIGATION[J]. 2015, 125(12): 4407-4420, [23] Ren, Jinqi, Feng, Lei, Bai, Yujie, Pei, Haohong, Yuan, Zengqiang, Feng, Wei. Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule. BIOCHEMICAL JOURNAL[J]. 2015, 468: 133-144, https://www.webofscience.com/wos/woscc/full-record/WOS:000353895700012.
[24] Zhang, Yan, Wang, Wenjuan, Chen, Jia, Zhang, Kai, Gao, Feng, Gao, Bingquan, Zhang, Shuai, Dong, Mingdong, Besenbacher, Flemming, Gong, Weimin, Zhang, Mingjie, Sun, Fei, Feng, Wei. Structural Insights into the Intrinsic Self-Assembly of Par-3 N-Terminal Domain. STRUCTURE[J]. 2013, 21(6): 997-1006, http://dx.doi.org/10.1016/j.str.2013.04.004.
[25] Wang, Chao, Li, Wei, Ren, Jinqi, Fang, Jingqi, Ke, Huimin, Gong, Weimin, Feng, Wei, Wang, Chihchen. Structural Insights into the Redox-Regulated Dynamic Conformations of Human Protein Disulfide Isomerase. ANTIOXIDANTS & REDOX SIGNALING[J]. 2013, 19(1): 44-53, http://www.irgrid.ac.cn/handle/1471x/756684.
[26] Wu, Ye E, Huo, Lin, Maeder, Celine I, Feng, Wei, Shen, Kang. The Balance between Capture and Dissociation of Presynaptic Proteins Controls the Spatial Distribution of Synapses. NEURON[J]. 2013, 78(6): 994-1011, http://dx.doi.org/10.1016/j.neuron.2013.04.035.
[27] Cong Yu, Jizhong Lou, Jingjing Wu, Lifeng Pan, Wei Feng, Mingjie Zhang. Membrane-induced Lever Arm Expansion Allows Myosin VI to Walk with Large and Variable Step Sizes. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2012, 287(42): 35021-35035, [28] Huo, Lin, Yue, Yang, Ren, Jinqi, Yu, Jiang, Liu, Junlin, Yu, Yong, Ye, Fei, Xu, Tao, Zhang, Mingjie, Feng, Wei. The CC1-FHA tandem as a central hub for controlling the dimerization and activation of kinesin-3 KIF1A. STRUCTURE[J]. 2012, 20(9): 1550-1561, http://dx.doi.org/10.1016/j.str.2012.07.002.
[29] Wang, Chao, Yu, Jiang, Huo, Lin, Wang, Lei, Feng, Wei, Wang, Chihchen. Human Protein-disulfide Isomerase Is a Redox-regulated Chaperone Activated by Oxidation of Domain a '. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2012, 287(2): 1139-1149, http://dx.doi.org/10.1074/jbc.M111.303149.
[30] Huo, Lin, Wen, Wenyu, Wang, Rui, Kam, Chuen, Xia, Jun, Feng, Wei, Zhang, Mingjie. Cdc42-dependent formation of the ZO-1/MRCK beta complex at the leading edge controls cell migration. EMBO JOURNAL[J]. 2011, 30(4): 665-678, http://www.irgrid.ac.cn/handle/1471x/757443.
[31] Feng, Wei, Zhang, Mingjie. Organization and Dynamics of PDZ Domain-Related Supramodules in the Postsynaptic Density. NAT REV NEUROSCI[J]. 2009, 10(2): 87-99, [32] Yu, Cong, Feng, Wei, Miyanoiri, Yohei, Wen, Wenyu, Zhao, Yanxiang, Zhang, Mingjie. Myosin VI undergoes cargo-mediated dimerization. CELL[J]. 2009, 138(3): 537-548, http://dx.doi.org/10.1016/j.cell.2009.05.030.
[33] Feng, Wei, Wu, Hao, Chan, Ling-Nga, Zhang, Mingjie. The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localization. THE EMBO JOURNAL[J]. 2007, 26(11): 2786-2796, https://www.webofscience.com/wos/woscc/full-record/WOS:000247084100016.
[34] Wu, Hao, Feng, Wei, Chen, Jia, Chan, LingNga, Huang, Siyi, Zhang, Mingjie. PDZ domains of Par-3 as potential phosphoinositide signaling integrators. MOLECULAR CELL[J]. 2007, 28(5): 886-898, http://dx.doi.org/10.1016/j.molcel.2007.10.028.
[35] Feng, W, Long, JF, Zhang, MJ. A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2005, 102(19): 6861-6866, [36] Long, JF, Feng, W, Wang, R, Chan, LN, Ip, FCF, Xia, J, Ip, NY, Zhang, MJ. Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2005, 12(8): 722-728, https://www.webofscience.com/wos/woscc/full-record/WOS:000230956400023.
[37] Feng, W, Long, JF, Fan, JS, Suetake, T, Zhang, MJ. The tetrameric L27 domain complex as an organization platform for supramolecular assemblies. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2004, 11(5): 475-480, https://www.webofscience.com/wos/woscc/full-record/WOS:000221069100016.
[38] Feng, W, Shi, YW, Li, M, Zhang, MJ. Tandem PDZ repeats in glutamate receptor-interacting proteins have a novel mode of PDZ domain-mediated target binding. NATURE STRUCTURAL BIOLOGY[J]. 2003, 10(11): 972-978, https://www.webofscience.com/wos/woscc/full-record/WOS:000186229100019.