基本信息

王晓晨  女  博导  中国科学院生物物理研究所
电子邮件: wangxiaochen@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码: 100101

研究领域

凋亡细胞的吞噬及降解过程是整个细胞凋亡程序中不可缺少的一环,它在组织重塑,炎症抑制和免疫应答调控中起着重要的作用。对死细胞清除的障碍会引起诸如哮喘、类风湿性关节炎和狼疮等炎症疾病和自身免疫紊乱。

利用秀丽隐杆线虫作为模式动物,我们实验室运用遗传学,细胞生物学和生化的方法来研究凋亡细胞清除的分子机制。我们运用特异的正向遗传学及反向遗传学筛选手段寻找参与凋亡细胞清除过程的新基因,并对所鉴定的相关基因展开凋亡细胞吞噬,降解过程调节机制的研究,包括凋亡细胞信号的展示,识别,凋亡细胞的吞噬和降解,溶酶体动态变化及调控机制

招生信息

   
招生专业
071009-细胞生物学
071009-细胞生物学
招生方向
以秀丽线虫为模式研究凋亡细胞的清除机制及溶酶体动态变化在发育和胁迫应答中的作用
溶酶体功能及动态变化的调控机制

教育背景

1998-05--1999-05   比利时根特大学/佛兰德斯生物科技研究所   访问学生
1994-09--1999-07   北京大学   博士
1988-09--1992-07   山东大学   学士
学历
研究生学历
学位
博士学位

工作经历

   
工作简历
2015-01~现在, 中科院生物物理研究所, 研究员 实验室主任
2011-07~2014-12,北京生命科学研究所, 高级研究员 实验室主任
2006-05~2011-06,北京生命科学研究所, 研究员 实验室主任
1999-09~2015-04,科罗拉多大学, 博士后
社会兼职
2020-08-01-今,Cell death and disease, 编委
2020-01-01-今,Journal of genetics and genomics, 副主编
2018-01-01-今,eLife Jan. 2018-至今, 编委会成员
2017-01-01-今,Journal of Cell Biology, 编委
2015-10-01-今,中国生物物理学会膜生物分会, 理事
2015-07-01-今,TRAFFIC, 编委
2014-10-01-今,北京市生物工程学会, 理事
2013-12-31-今,北京细胞生物学会, 理事
2012-09-30-今,PLOS ONE Editorial Board, 编委
2006-04-30-今,实验室主任, 主任 博士生导师

教授课程

细胞生物学实验
生命科技经典文献深度研读
细胞凋亡及自噬的生物学研究
遗传学
线虫遗传及发育生物学
授课信息

2011年秋季- 硕士学位课程 线虫遗传及发育生物学 8学时 PTN 

2013年春季- 博士学位课程 线虫遗传及发育生物学 8学时 PTN  
2014
年春季- 博士学位课程 遗传学 8学时 PTN

2016年春季- 本科生课程 细胞凋亡与自噬的生物学研究 20学时

2017年春季- 本科生课程 生命科技经典文献深度研读 18学时

2018年秋季- 本科生课程  细胞生物学实验  20学时

2019年秋季- 本科生课程  细胞生物学实验  24学时

2020年秋季- 本科生课程  细胞生物学实验  24学时

专利与奖励

   
奖励信息
(1) 2018年国务院政府特殊津贴”人员, 一等奖, 国家级, 2019
(2) 国家“万人计划”获得者, 一等奖, 国家级, 2016
(3) 中科院“****”获得者, 一等奖, 院级, 2015
(4) 中青年科技创新领军人才, 一等奖, 部委级, 2014
(5) “国家百千万人才工程”获得者, 一等奖, 部委级, 2014
(6) 第十届中国青年女科学家, 一等奖, 国家级, 2013
(7) 国家杰出青年科学基金获得者, 一等奖, 国家级, 2013
(8) 药明康德生命化学研究奖学者奖, , 其他, 2012
(9) 霍华德.休斯(HHMI)国际青年科学家奖, 一等奖, 专项, 2012

出版信息

   
发表论文
[1] Shi L,, Jian Y, Li M, Yang C, Hao T, Wang X. Filamin FLN-2 promotes MVB biogenesis by mediating vesicle docking on the actin cytoskeleton. J Cell Biol[J]. 2022, 221(7): [2] Li, Yuan, Wang, Xin, Li, Meijiao, Yang, Chonglin, Wang, Xiaochen. M05B5.4 (lysosomal phospholipase A2) promotes disintegration of autophagic vesicles to maintain C. elegans development. Autophagy[J]. 2021, doi:10.1080/15548627.2021.1943178: [3] Yang, C, Wang X. Lysosome biogenesis: Regulation and functions.. J Cell Biol[J]. 2021, 220(6): e202102001-, [4] Xin Li, Yanan Sun, Xiaochen Wang. Probing lysosomal activity in vivo. 生物物理学报:英文版[J]. 2021, 7(1): 1-7, [5] Sun, Yanan, Li, Meijiao, Zhao, Dongfeng, Li, Xin, Yang, Chonglin, Wang, Xiaochen. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. ELIFE[J]. 2020, 9: https://doaj.org/article/5e0bbc27b9234ee683bfcb96322653dd.
[6] Junyan Hu, Shiya Cheng, Haibin Wang, Xin Li, Sun Liu, Mengmeng Wu, Yubing Liu, Xiaochen Wang. Distinct roles of two myosins in C. elegans spermatid differentiation.. PLoS Biology[J]. 2019, 17(4): https://doaj.org/article/7c60f06e0b444312aa5dcdbd595fa17f.
[7] 王晓晨. An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Development.. Dev Cell. 2019, [8] Zhang, Junbing, Liu, Jinchao, Norris, Anne, Grant, Barth D, Wang, Xiaochen. A novel requirement for ubiquitin-conjugating enzyme UBC-13 in retrograde recycling of MIG-14/Wntless and Wnt signaling. MOLECULAR BIOLOGY OF THE CELL[J]. 2018, 29(17): 2098-2112, https://www.webofscience.com/wos/woscc/full-record/WOS:000446092200006.
[9] Liu, Yubing, Zou, Wei, Yang, Peiguo, Wang, Li, Ma, Yan, Zhang, Hong, Wang, Xiaochen. Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotide homeostasis during C. elegans development. ELIFE[J]. 2018, 7: https://doaj.org/article/70abfc792d104018821d3a329c64739c.
[10] Liu Jinchao, Li Meijiao, Li Lin, Chen She, Wang Xiaochen. Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation.. The Journal of cell biology. 2018, 217(1): [11] Cheng Shiya, Liu Kai, Yang Chonglin, Wang Xiaochen. Dissecting Phagocytic Removal of Apoptotic Cells in Caenorhabditis elegans.. Methods in molecular biology (Clifton, N.J.). 2017, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPD9F8896C2A01A0A6FE7B0398530FCC9FD&DbName=SJPD_06&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[12] Yin Jianhua, Huang Yaling, Guo Pengfei, Hu Siqi, Yoshina Sawako, Xuan Nan, Gan Qiwen, Mitani Shohei, Yang Chonglin, Wang Xiaochen. GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans .. The Journal of cell biology. 2017, 216(6): 1775-1794, [13] Yang, Chonglin, Wang, Xiaochen. Cell biology in China: Focusing on the lysosome. TRAFFICnull. 2017, 18(6): 348-357, https://www.webofscience.com/wos/woscc/full-record/WOS:000401521600003.
[14] Su Yaning, Li Li, Wang Haibin, Wang Xiaochen, Zhang Zhiyuan. All-in-One azides: empowered click reaction for in vivo labeling and imaging of biomolecules.. Chemical communications (Cambridge, England). 2016, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPD1366D5F54E158FF6D59DE37FE52EF160&DbName=SJPD_05&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[15] Xiaochen Wang, Chonglin Yang. Programmed cell death and clearance of cell corpses in Caenorhabditis elegans. Cellular and Molecular Life Sciences,. 2016, 73: https://www.webofscience.com/wos/woscc/full-record/WOS:000377775800010.
[16] Li Yuan, Chen Baohui, Zou Wei, Wang Xin, Wu Yanwei, Zhao Dongfeng, Sun Yanan, Liu Yubing, Chen Lianwan, Miao Long, Yang Chonglin, Wang Xiaochen. The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity.. The Journal of cell biology. 2016, 167-185, [17] Shiya Cheng, Kun Wang, Wei Zou, Rui Miao, Yaling Huang, Haibin Wang, Xiaochen Wang. PtdIns(4,5)P2 and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance. The Journal of Cell Biology. 2015, 210(3): [18] Wu, Yanwei, Cheng, Shiya, Zhao, Hongyu, Zou, Wei, Yoshina, Sawako, Mitani, Shohei, Zhang, Hong, Wang, Xiaochen. PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation. EMBO REPORTS[J]. 2014, 15(9): 973-981, https://www.webofscience.com/wos/woscc/full-record/WOS:000341711600011.
[19] 王晓晨. Inactivation of C. elegans aminopeptidase DNPP-1 restores endocytic sorting and recycling in tat-1 mutants.. Mol Biol Cell. 2013, [20] Wang, Haibin, Lu, Qun, Cheng, Shiya, Wang, Xiaochen, Zhang, Hong. Autophagy activity contributes to programmed cell death in Caenorhabditis elegans. AUTOPHAGY[J]. 2013, 9(12): 1975-1982, https://www.webofscience.com/wos/woscc/full-record/WOS:000328299800005.
[21] 王晓晨. Autophagy genes coordinate with the class II PI3 kinase PIKI-1 to regulate apoptotic cell clearance in C. elegans.. Autophagy. 2013, [22] Zou, Wei, Wang, Xiaochen, Vale, Ronald D, Ou, Guangshuo. Autophagy genes promote apoptotic cell corpse clearance. AUTOPHAGYnull. 2012, 8(8): 1267-1268, http://www.irgrid.ac.cn/handle/1471x/756992.
[23] Zhang Yan, Wang Haibin, KageNakadai Eriko, Mitani Shohei, Wang Xiaochen. C. elegans secreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpse engulfment.. Current biology : CB. 2012, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPD120727548324&DbName=SJPD_01&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[24] Kang, Yanyong, Zhao, Dongfeng, Liang, Huanhuan, Liu, Bin, Zhang, Yan, Liu, Qinwen, Wang, Xiaochen, Liu, Yingfang. Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment. GENES & DEVELOPMENT[J]. 2012, 26(12): 1339-1350, http://www.irgrid.ac.cn/handle/1471x/756946.
[25] Liu, Bin, Du, Hongwei, Rutkowski, Rachael, Gartner, Anton, Wang, Xiaochen. LAAT-1 Is the Lysosomal Lysine/Arginine Transporter That Maintains Amino Acid Homeostasis. SCIENCE[J]. 2012, 337(6092): 351-354, https://www.webofscience.com/wos/woscc/full-record/WOS:000306542600054.
[26] Pengfei Guo, Xiaochen Wang. Rab GTPases act in sequential steps to regulate phagolysosome formation. Small GTPases. 2010, 1(3): 170-173, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116604/.
[27] Guo, Pengfei, Hu, Tianjing, Zhang, Juan, Jiang, Shanya, Wang, Xiaochen. Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2010, 107(42): 18016-18021, https://www.webofscience.com/wos/woscc/full-record/WOS:000283184800033.
[28] Chen, Baohui, Jiang, Yue, Zeng, Sheng, Yan, Jiacong, Li, Xin, Zhang, Yan, Zou, Wei, Wang, Xiaochen. Endocytic Sorting and Recycling Require Membrane Phosphatidylserine Asymmetry Maintained by TAT-1/CHAT-1. PLOS GENETICS[J]. 2010, 6(12): https://doaj.org/article/a17144629db04a4ab8e4f9ce71c14ceb.
[29] Wang, Xiaochen, Li, Weida, Zhao, Dongfeng, Liu, Bin, Shi, Yong, Chen, Baohui, Yang, Hengwen, Guo, Pengfei, Geng, Xin, Shang, Zhihong, Peden, Erin, KageNakadai, Eriko, Mitani, Shohei, Xue, Ding. Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. NATURE CELL BIOLOGY[J]. 2010, 12(7): 655-U69, https://www.webofscience.com/wos/woscc/full-record/WOS:000279374400009.
[30] Zou, Wei, Lu, Qun, Zhao, Dongfeng, Li, Weida, Mapes, James, Xie, Yuting, Wang, Xiaochen. Caenorhabditis elegans Myotubularin MTM-1 Negatively Regulates the Engulfment of Apoptotic Cells. PLOS GENETICS[J]. 2009, 5(10): https://doaj.org/article/b9c846e63ad441a889251b08891159fc.
[31] Li, Weida, Zou, Wei, Zhao, Dongfeng, Yan, Jiacong, Zhu, Zuoyan, Lu, Jing, Wang, Xiaochen. C-elegans Rab GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5. DEVELOPMENT[J]. 2009, 136(14): 2445-2455, https://www.webofscience.com/wos/woscc/full-record/WOS:000267218500014.
[32] Lu, Qun, Zhang, Yan, Hu, Tianjing, Guo, Pengfei, Li, Weida, Wang, Xiaochen. C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells. DEVELOPMENT[J]. 2008, 135(6): 1069-1080, https://www.webofscience.com/wos/woscc/full-record/WOS:000253426300008.
[33] DarlandRansom, Monica, Wang, Xiaochen, Sun, ChunLing, Mapes, James, GengyoAndo, Keiko, Mitani, Shohei, Xue, Ding. Role of C-elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. SCIENCE[J]. 2008, 320(5875): 528-531, https://www.webofscience.com/wos/woscc/full-record/WOS:000255249300050.
[34] 王晓晨. C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid cramblase SCRM-1.. 2007, [35] Yang Chonglin, Yan Nieng, Parish Jay, Wang Xiaochen, Shi Yigong, Xue Ding. RNA aptamers targeting the cell death inhibitor CED-9 induce cell killing in Caenorhabditis elegans.. The Journal of biological chemistry. 2006, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPD12102300099506&DbName=SJPD_02&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[36] Wang, XC, Wu, YC, Fadok, VA, Lee, MC, GengyoAndo, K, Cheng, LC, Ledwich, D, Hsu, PK, Chen, JY, Chou, BK, Henson, P, Mitani, S, Xue, D. Cell corpse engulfment mediated by C-elegans phosphatidylserine receptor through CED-5 and CED-12. SCIENCE[J]. 2003, 302(5650): 1563-1566, https://www.webofscience.com/wos/woscc/full-record/WOS:000186802200043.
[37] 王晓晨. Mechanisms of AIF-apoptotic DNA degradation in Caenorhabditis elegans.. 2002, [38] Wang X, Bauw G, Van Damme E J, Peumans W J, Chen Z L, Van Montagu M, Angenon G, Dillen W. Gastrodianin-like mannose-binding proteins: a novel class of plant proteins with antifungal properties.. The Plant journal : for cell and molecular biology. 2001, [39] Huang Jie, Wang Haibin, Chen Yingyu, Wang Xiaochen, Zhang Hong. Residual body removal during spermatogenesis in C. elegans requires genes that mediate cell corpse clearance. Development (Cambridge, England). 139(24): 4613-4622, http://www.irgrid.ac.cn/handle/1471x/756914.
发表著作
(1) 细胞生物学方法, Methods for Studying Programmed Cell Death in C. elegans,Methods in Cell Biology, Institutes of Molecular and Cellular Biology, National Taiwan University, 2012-01, 第 2 作者

科研活动

已完成科研项目
(1). 国家重大科学研究计划项目(863),2007AA02Z1A0、 线虫凋亡细胞清除机制的研究、 2007.06.01-2010.11.30、 696万元、已结题、主持。
(2). 国家重大科学研究计划项目(973), 2010CB835202、 秀丽线虫凋亡细胞清除机制的研究、 2010.05.01-2012.12.31、750万、已结题、主持。
在研项目
( 1 ) 胁迫环境中自噬-溶酶体通路与细胞代谢调控机制, 参与, 国家级, 2013-01--2017-12
( 2 ) 细胞生物学, 主持, 国家级, 2014-01--2017-12
( 3 ) 凋亡细胞识别、吞噬与降解的分子机制, 参与, 部委级, 2017-01--2021-12
( 4 ) 以秀丽线虫为模式解析溶酶体, 主持, 国家级, 2017-01--2021-12
( 5 ) 细胞分泌和降解相关膜行为的蛋白质机器, 主持, 国家级, 2016-07--2021-06
( 6 ) 生物膜相关蛋白质机器的动态变化、结构与功能, 主持, 国家级, 2018-01--2021-12
参与会议
(1)Regulation of lysosome activity during C. elegans development   2018-03-29
(2)To eat and digest: Essential Role of PI3Ks in Clearance of Apoptotic Cells   2017-06-24
(3)凋亡细胞的吞噬及降解机制   2016-10-20
(4)Chair   2016-06-25
(5)Regulation of Rab GTPase 2 during Phagosome and Endosome Maturation in C. elegans   2016-05-21
(6)LMA-1/SCAV-3 Maintains Lysosome Integrity and Normal Adult Lifespan in C. elegans   2015-12-15
(7)To eat correctly:Phospholipid signaling in apoptotic cell recognition and internalization   2015-11-13
(8)Coordinated Actions of Phosphoinositides Regulates Phagocytosis of Apoptotic Cells in C. elegans   2015-07-15
(9)SCAV-3 Maintains Lysosome (LMA-1Maintains Lysosome integrity for normal larval developement and adult life span)   2015-03-20
(10)To eat correctly:Phospholipid signaling in apoptotic cell recognition and internalization   Xiaochen Wang   2014-07-18
(11)Lysosome Function and Dynamics: learning from worms   Xiaochen Wang   2013-09-11
(12)Lysosome Function and Dynamics: learning from worms    Xiaochen Wang   2013-09-10
(13)Secreted lipid-binding proteins mediate cell corpse recognition in C. elegans   Xiaochen Wang   2013-06-24
(14)Lysosome Function and Dynamics: learning from worms   Xiaochen Wang   2013-05-09
(15)Rab GTPases function coordinately to regulate phagosome maturation in C. elegans    Xiaochen Wang   2012-09-05

指导学生

已指导学生

杜红伟  博士研究生  071009-细胞生物学  

现指导学生

郝田超  博士研究生  071009-细胞生物学  

刘希璐  硕士研究生  071010-生物化学与分子生物学  

胡俊岩  博士研究生  071009-细胞生物学  

陈力榕  硕士研究生  071009-细胞生物学  

廖咨冰  硕士研究生  071010-生物化学与分子生物学  

张倩倩  博士研究生  071009-细胞生物学  

王莉  硕士研究生  071009-细胞生物学  

胡斯琪  博士研究生  071009-细胞生物学  

陆治江  博士研究生  071009-细胞生物学