基本信息
汪海林  男  博导  中国科学院生态环境研究中心
电子邮件: HLWang@rcees.ac.cn
通信地址: 北京市海淀区双清路18号
邮政编码: 100085

招生信息

   
招生专业
070302-分析化学
0710Z1-基因组学
招生方向
高灵敏生物分析
DNA损伤与修复
表观遗传学

教育背景

1994-09--1997-06   中科院大连化学物理研究所   理学博士
1991-09--1994-08   中科院大连化学物理研究所   理学硕士
1987-09--1991-07   武汉大学化学系   理学学士

工作经历

   
工作简历
2005-12~现在, 中科院生态环境研究中心, 研究员、博士生导师
2000-07~2005-12,University of Alberta, postdoctoral fellow, research associate
1997-07~2000-07,中科院大连化物所, 助研、副研
社会兼职
2018-01-01-2020-12-31,Analytical Chemistry, 编委
2017-10-01-今,Journal of Environmental Sciences, 编委
2016-03-01-今,北京理化分析测试协会色谱分会, 副理事长
2016-01-01-今,Genomics, Proteomics & Bioinformatics, 编委
2013-08-01-今,J Sep Sci, 编委
2013-01-01-今,《中国科学化学》, 编委
2010-01-01-今,《环境化学》, 编委

教授课程

前沿讲座
环境与健康
环境健康前沿研究
环境与健康前沿研究

专利与奖励

   
奖励信息
(1) 中国分析测试协会科学技术奖, 特等奖, 其他, 2015
(2) 中科院优秀研究生导师奖, 院级, 2015
(3) 中国分析测试协会科学技术奖, 一等奖, 其他, 2013
(4) 中科院优秀研究生指导教师奖, 院级, 2013
(5) 中科院优秀研究生导师奖, 院级, 2012
(6) 中国分析测试协会科学技术奖, 一等奖, 其他, 2010
(7) 中国教育部自然科学奖, 一等奖, 部委级, 2007
(8) 中科院院长奖学金特别奖, 特等奖, 其他, 1997
专利成果
( 1 ) 脂蛋白毛细管涂层及其制备方法, 发明, 2008, 第 1 作者, 专利号: 200810240105.9
( 2 ) 荧光偏振增强免疫毛细管电泳分析, 发明, 2009, 第 1 作者, 专利号: 200910092316.7
( 3 ) 量子点增强的高灵敏DNA加合物分析方法, 发明, 2009, 第 1 作者, 专利号: 20091023697.2
( 4 ) 毛细管电泳-柱上激光诱导荧光偏振检测装置, 发明, 2009, 第 1 作者, 专利号: 200910088212.9
( 5 ) 一种用于DNA酶切为单核苷的级联酶反应器, 发明, 2016, 第 1 作者, 专利号: 201610544434.7

出版信息

   
发表论文
[1] Wang Xiuzhi, Wang Mengke, Dai Xinyuan, Han Xiao, Zhou Yu, Lai Weiyi, Zhang Liyuan, Yang Ying, Chen Yusheng, Wang Hailin, Zhao Yong-Liang, Shen Bin, Zhang Yuhan, Huang Ying, Yang Yun-Gui. RNA 5-methylcytosine regulates YBX2-dependent liquid-liquid phase separation. Fundamental Research[J]. 2022, 2: 48-55, [2] Huang, Xin, Bashkenova, Nazym, Hong, Yantao, Lyu, Cong, Guallar, Diana, Hu, Zhe, Malik, Vikas, Li, Dan, Wang, Hailin, Shen, Xiaohua, Zhou, Hongwei, Wang, Jianlong. A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency. CELL REPORTS[J]. 2022, 39(10): [3] Chen, Shaokun, Lai, Weiyi, Li, Xiangjun, Wang, Hailin. Necrosulfonamide Selectively Induces DNA Double-Strand Breaks in Acute Myeloid Leukemia Cells. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2022, 35(3): 387-391, http://dx.doi.org/10.1021/acs.chemrestox.2c00044.
[4] 汪海林. Rare and misincorporated DNA N6 -methyladenine. Cell Discovery[J]. 2022, 8: 39-, [5] Ren, Yun, Zheng, Jing, Wang, Hailin. Transiently gene-modulated cell reporter for ultrasensitive detection of estrogen-like compounds in tap water. CHEMOSPHERE[J]. 2022, 289: http://dx.doi.org/10.1016/j.chemosphere.2021.133161.
[6] Liu, Shuyu, Yang, Renjun, Chen, Yongjiu, Zhao, Xingchen, Chen, Shaokun, Yang, Xuezhi, Cheng, Zhanwen, Hu, Bowen, Liang, Xiaoxing, Yin, Nuoya, Liu, Qian, Wang, Hailin, Liu, Sijin, Faiola, Francesco. Development of Human Lung Induction Models for Air Pollutants' Toxicity Assessment. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2021, 55(4): 2440-2451, https://www.webofscience.com/wos/woscc/full-record/WOS:000620926800025.
[7] Ma, Yangde, Zhang, Ning, Chen, Shaokun, Sun, Jingwei, Liu, Yan, Li, Xiangjun, Wang, Hailin. One-pot intramolecular cyclization of 5-hydroxymethylcytosine for sequencing DNA hydroxymethylation at single-base resolution. ANALYST[J]. 2021, 146(3): 820-824, http://dx.doi.org/10.1039/d0an01981j.
[8] Liang, Ying, Lu, Qi, Li, Wei, Zhang, Dapeng, Zhang, Fanglin, Zou, Qingping, Chen, Lu, Tong, Ying, Liu, Mengxing, Wang, Shaoxuan, Li, Wenxuan, Ren, Xiaoguang, Xu, Peng, Yang, Zhicong, Dong, Shihua, Zhang, Baolong, Huang, Yanni, Li, Daqiang, Wang, Hailin, Yu, Wenqiang. Reactivation of tumour suppressor in breast cancer by enhancer switching through NamiRNA network. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(15): 8556-8572, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000697383500017.
[9] Hailin Wang. Profiling of the assembly of RecA nucleofilaments implies a potential target for environmental factors to disturb DNA damage repair. J. Environ. Sci. (China). 2021, [10] Liu, Xiaoling, Lai, Weiyi, Li, Yao, Chen, Shaokun, Liu, Baodong, Zhang, Ning, Mo, Jiezhen, Lyu, Cong, Zheng, Jing, Du, YaRui, Jiang, Guibin, Xu, GuoLiang, Wang, Hailin. N-6-methyladenine is incorporated into mammalian genome by DNA polymerase. CELL RESEARCH. 2021, 31(1): 94-97, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853133/.
[11] Yuan, Zheng, Zhang, Dapeng, Yu, Fangzhi, Ma, Yangde, Liu, Yan, Li, Xiangjun, Wang, Hailin. Precise sequencing of single protected-DNA fragment molecules for profiling of protein distribution and assembly on DNA. CHEMICAL SCIENCE[J]. 2021, 12(6): 2039-2049, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179319/.
[12] Ren, Yun, Liu, Yan, Wang, Hailin. Identification of epigenetic regulators in the estrogen signaling pathway via siRNA screening. MOLECULAR OMICS[J]. 2021, 17(4): 596-606, http://dx.doi.org/10.1039/d1mo00040c.
[13] Li, Zhe, Lyu, Cong, Ren, Yun, Wang, Hailin. Role of TET Dioxygenases and DNA Hydroxymethylation in Bisphenols-Stimulated Proliferation of Breast Cancer Cells. ENVIRONMENTAL HEALTH PERSPECTIVES[J]. 2020, 128(2): http://dx.doi.org/10.1289/EHP5862.
[14] Hailin Wang. Fluorescent imaging of cytoplasmic nucleolin in live cells by functionalized-engineered aptamer.. Chem Comm. 2020, [15] Tang, Yongyan, Gao, ChunChun, Gao, Ying, Yang, Ying, Shi, Boyang, Yu, JiaLi, Lyu, Cong, Sun, BaoFa, Wang, HaiLin, Xu, Yunyuan, Yang, YunGui, Chong, Kang. OsNSUN2-Mediated 5-Methylcytosine mRNA Modification Enhances Rice Adaptation to High Temperature. DEVELOPMENTAL CELL[J]. 2020, 53(3): 272-+, http://dx.doi.org/10.1016/j.devcel.2020.03.009.
[16] Yu, Fangzhi, Yuan, Zheng, Zhang, Dapeng, Liu, Yan, Zhao, Qiang, Wang, Hailin. High-affinity and undissociated capillary electrophoresis for DNA strand exchange analysis. CHEMICAL COMMUNICATIONS[J]. 2020, 56(54): 7403-7406, https://www.webofscience.com/wos/woscc/full-record/WOS:000545820900031.
[17] Hailin Wang. Protonation-suppressing free LC-MS/MS analysis for profiling of DNA cytosine modifications in adult Mice. Anal Chem. 2020, [18] Zhang, Ning, Deng, Wenchao, Li, Yao, Ma, Yangde, Liu, Yan, Li, Xiangjun, Wang, Hailin. Formic Acid of ppm Enhances LC-MS/MS Detection of UV Irradiation-Induced DNA Dimeric Photoproducts. ANALYTICAL CHEMISTRY[J]. 2020, 92(1): 1197-1204, http://dx.doi.org/10.1021/acs.analchem.9b04327.
[19] Hailin Wang. Quantitative assessment of adenosine triphosphatase hydrolytic activity by ultrafiltration-coupled ion-pair reversed-phase high-performance liquid chromatography. J. Sep. Sci.. 2020, [20] Zhang, Huifang, Gao, Qinqin, Tan, Shuo, You, Jia, Lyu, Cong, Zhang, Yunpeng, Han, Mengmeng, Chen, Zhaosu, Li, Jialun, Wang, Hailin, Liao, Lujian, Qin, Jun, Li, Jiwen, Wong, Jiemin. SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1. NUCLEIC ACIDS RESEARCH[J]. 2019, 47(17): 9053-9068, http://dx.doi.org/10.1093/nar/gkz626.
[21] Yu, Fangzhi, Zhao, Qiang, Zhang, Dapeng, Yuan, Zheng, Wang, Hailin. Affinity Interactions by Capillary Electrophoresis: Binding, Separation, and Detection. ANALYTICAL CHEMISTRY[J]. 2019, 91(1): 372-387, http://dx.doi.org/10.1021/acs.analchem.8b04741.
[22] Zhao, Chao, Tang, Zhi, Chung, Arthur Chi Kong, Wang, Hailin, Cai, Zongwei. Metabolic perturbation, proliferation and reactive oxygen species jointly contribute to cytotoxicity of human breast cancer cell induced by tetrabromo and tetrachloro bisphenol A. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2019, 170: 495-501, http://dx.doi.org/10.1016/j.ecoenv.2018.12.018.
[23] Wang, Fengbang, Chen, Ying, Wang, Yuanyuan, Yin, Yongguang, Qu, Guangbo, Song, Maoyong, Wang, Hailin. Ultra-long silver nanowires induced mitotic abnormalities and cytokinetic failure in A549 cells. NANOTOXICOLOGY[J]. 2019, 13(4): 543-557, [24] Peng, Shiming, Xiao, Wen, Ju, Dapeng, Sun, Baofa, Hou, Nannan, Liu, Qianlan, Wang, Yanli, Zhao, Haijiao, Gao, Chunchun, Zhang, Song, Cao, Ran, Li, Pengfei, Huang, Huanwei, Ma, Yongfen, Wang, Yankai, Lai, Weiyi, Ma, Zhixiong, Zhang, Wei, Huang, Song, Wang, Hailin, Zhang, Zhiyuan, Zhao, Liping, Cai, Tao, Zhao, YongLiang, Wang, Fengchao, Nie, Yongzhan, Zhi, Gang, Yang, YunGui, Zhang, Eric Erquan, Huang, Niu. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. SCIENCE TRANSLATIONAL MEDICINE[J]. 2019, 11(488): [25] Wu, Danni, Zhang, Ning, Kong, Bingjie, Hang, Haiying, Wang, Hailin. Synthesis and purification of biotinylated oligodeoxynucleotides containing single TpT dimeric pyrimidine (6-4) pyrimidone lesion. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2019, 411(18): 4123-4129, http://dx.doi.org/10.1007/s00216-018-01572-6.
[26] Yin, Junfa, Zhang, Ning, Wang, Hailin. Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure. TRAC-TRENDS IN ANALYTICAL CHEMISTRY[J]. 2019, 120: http://dx.doi.org/10.1016/j.trac.2019.115645.
[27] Zhang, Dapeng, Wang, Hailin. Fluorescence Anisotropy Reduction of An Allosteric G-Rich Oligonucleotide for Specific Silver Ion and Cysteine Detection Based on the G-Ag+-G Base Pair. ANALYTICAL CHEMISTRY[J]. 2019, 91(22): 14538-14544, https://www.webofscience.com/wos/woscc/full-record/WOS:000498280100051.
[28] Zhao, Zuodong, Lan, Mengying, Li, Jingjing, Dong, Qiang, Li, Xiang, Liu, Baodong, Li, Gang, Wang, Hailin, Zhang, Zhuqiang, Zhu, Bing. The proinflammatory cytokine TNF induces DNA demethylation-dependent and -independent activation of interleukin-32 expression. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(17): 6785-6795, http://dx.doi.org/10.1074/jbc.RA118.006255.
[29] Zhao, Chao, Zhu, Lin, Li, Ruijin, Wang, Hailin, Cai, Zongwei. Omics approach reveals metabolic disorders associated with the cytotoxicity of airborne particulate matter in human lung carcinoma cells. ENVIRONMENTAL POLLUTION[J]. 2019, 246: 45-52, http://dx.doi.org/10.1016/j.envpol.2018.11.108.
[30] Liu, Jiao, Jiang, Jinhua, Mo, Jiezhen, Liu, Dan, Cao, Dan, Wang, Hailin, He, Yufei, Wang, Hongyang. Global DNA 5-Hydroxymethylcytosine and 5-Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma. HEPATOLOGY[J]. 2019, 69(1): 196-208, https://www.webofscience.com/wos/woscc/full-record/WOS:000455054900017.
[31] Zhang, Ting, Guan, Xiaowen, Choi, Un Lam, Dong, Qiang, Lam, Melody M T, Zeng, Jianming, Xiong, Jun, Wang, Xianju, Poon, Terence C W, Zhang, Hongjie, Zhang, Xuanjun, Wang, Hailin, Xie, Ruiyu, Zhu, Bing, Li, Gang. Phosphorylation of TET2 by AMPK is indispensable in myogenic differentiation. EPIGENETICS & CHROMATIN[J]. 2019, 12(1): https://doaj.org/article/46ed7f8ac64e476986a9904db01fd009.
[32] Hailin Wang. darubicin Stimulates Cell Cycle- and TET2-Dependent Oxidation of DNA 5-Methylcytosine in Cancer Cells.. Chem Res Toxicol.. 2019, [33] Weiyi Lai, Jiezhen Mo, Junfa Yin, Cong Lyu, Hailin Wang. Profiling of epigenetic DNA modifications by advanced liquid chromatography-mass spectrometry technologies. Trends in Analytical Chemistry. 2019, 110: 173-182, http://dx.doi.org/10.1016/j.trac.2018.10.031.
[34] Du, Wenlong, Dong, Qiang, Zhang, Zhuqiang, Liu, Baodong, Zhou, Ting, Xu, Ruiming, Wang, Hailin, Zhu, Bing, Li, Yingfeng. Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(22): 8907-8917, http://dx.doi.org/10.1074/jbc.RA119.008008.
[35] Sun, Linlin, Li, Yapiao, Wang, Hailin, Zhao, Qiang. An aptamer assay for aflatoxin B1 detection using Mg2+ mediated free zone capillary electrophoresis coupled with laser induced fluorescence. TALANTA[J]. 2019, 204: 182-188, http://dx.doi.org/10.1016/j.talanta.2019.05.069.
[36] Zhang, Ning, Lu, Meiling, Duan, Xiaokun, Liu, Charles C, Wang, Hailin. In situ calibration of Direct Analysis in Real Time-mass spectrometry for direct quantification: Urine excretion rate index creatinine as an example. TALANTA[J]. 2019, 201: 134-142, http://dx.doi.org/10.1016/j.talanta.2019.03.092.
[37] Li, Xiang, Shang, Erchang, Dong, Qiang, Li, Yingfeng, Zhang, Jing, Xu, Shaohua, Zhao, Zuodong, Shao, Wei, Lv, Cong, Zheng, Yong, Wang, Hailin, Lei, Xiaoguang, Zhu, Bing, Zhang, Zhuqiang. Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2018, 293(19): 7423-7436, http://dx.doi.org/10.1074/jbc.RA117.000757.
[38] Yin, Ruichuan, Mo, Jiezhen, Dai, Jiayin, Wang, Hailin. Nickel(ii) inhibits the oxidation of DNA 5-methylcytosine in mammalian somatic cells and embryonic stem cells. METALLOMICS[J]. 2018, 10(3): 504-512, http://ir.rcees.ac.cn/handle/311016/40999.
[39] Xu, Tian, Yin, Junfa, Chen, Shaokun, Zhang, Dapeng, Wang, Hailin. Elevated 8-oxo-7,8-dihydro-2 '-deoxyguanosine in genome of T24 bladder cancer cells induced by halobenzoquinones. JOURNAL OF ENVIRONMENTAL SCIENCES[J]. 2018, 63: 133-139, http://dx.doi.org/10.1016/j.jes.2017.05.024.
[40] Kong, Bingjie, Cao, Yang, Wu, Danni, An, Lili, Ran, Fanlei, Lin, Yan, Ye, Chen, Wang, Hailin, Hang, Haiying. Affinity maturation of an antibody for the UV-induced DNA lesions 6,4 pyrimidine-pyrimidones. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2018, 102(15): 6409-6424, http://ir.rcees.ac.cn/handle/311016/40869.
[41] Liu, Xiaoling, Lai, Weiyi, Zhang, Ning, Wang, Hailin. Predominance of N-6-Methyladenine-Specific DNA Fragments Enriched by Multiple Immunoprecipitation. ANALYTICAL CHEMISTRY[J]. 2018, 90(9): 5546-5551, http://dx.doi.org/10.1021/acs.analchem.8b01087.
[42] Zhao, Chao, Xie, Peisi, Yong, Ting, Wang, Hailin, Chung, Arthur Chi Kong, Cai, Zongwei. MALDI-MS Imaging Reveals Asymmetric Spatial Distribution of Lipid Metabolites from Bisphenol S-Induced Nephrotoxicity. ANALYTICAL CHEMISTRY[J]. 2018, 90(5): 3196-3204, http://ir.rcees.ac.cn/handle/311016/40978.
[43] Yin, Junfa, Chen, Shaokun, Zhang, Ning, Wang, Hailin. Multienzyme Cascade Bioreactor for a 10 min Digestion of Genomic DNA into Single Nucleosides and Quantitative Detection of Structural DNA Modifications in Cellular Genomic DNA. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 10(26): 21883-21890, http://ir.rcees.ac.cn/handle/311016/40991.
[44] He, Wenteng, Zhang, Xiaobai, Zhang, Yalin, Zheng, Weisheng, Xiong, Zeyu, Hu, Xinjie, Wang, Mingzhu, Zhang, Linfeng, Zhao, Kun, Qiao, Zhibin, Lai, Weiyi, Lv, Cong, Kou, Xiaochen, Zhao, Yanhong, Yin, Jiqing, Liu, Wenqiang, Jiang, Yonghua, Chen, Mo, Xu, Ruimin, Le, Rongrong, Li, Chong, Wang, Hong, Wan, Xiaoping, Wang, Hailin, Han, Zhiming, Jiang, Cizhong, Gao, Shaorong, Chen, Jiayu. Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b. STEM CELL REPORTS[J]. 2018, 10(2): 477-493, http://dx.doi.org/10.1016/j.stemcr.2017.12.024.
[45] Li, Yingfeng, Zhang, Zhuqiang, Chen, Jiayu, Liu, Wenqiang, Lai, Weiyi, Liu, Baodong, Li, Xiang, Liu, Liping, Xu, Shaohua, Dong, Qiang, Wang, Mingzhu, Duan, Xiaoya, Tan, Jiajun, Zheng, Yong, Zhang, Pumin, Fan, Guoping, Wong, Jiemin, Xu, GuoLiang, Wang, Zhigao, Wang, Hailin, Gao, Shaorong, Zhu, Bing. Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1. NATURE[J]. 2018, 564(7734): 136-+, http://202.127.25.143/handle/331003/3472.
[46] Li, Cuiping, Lai, Weiyi, Wang, Hailin. An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS[J]. 2018, https://www.webofscience.com/wos/woscc/full-record/WOS:000444752100005.
[47] Dong, Qiang, Li, Xiang, Wang, ChengZhi, Xu, Shaohua, Yuan, Gang, Shao, Wei, Liu, Baodong, Zheng, Yong, Wang, Hailin, Lei, Xiaoguang, Zhang, Zhuqiang, Zhu, Bing. Roles of the CSE1L-mediated nuclear import pathway in epigenetic silencing. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(17): E4013-E4022, http://ir.rcees.ac.cn/handle/311016/41033.
[48] Lai, Weiyi, Lyu, Cong, Wang, Hailin. Vertical Ultrafiltration-Facilitated DNA Digestion for Rapid and Sensitive UHPLC-MS/MS Detection of DNA Modifications. ANALYTICAL CHEMISTRY[J]. 2018, 90(11): 6859-6866, http://ir.rcees.ac.cn/handle/311016/41081.
[49] Wang, ChenXin, Cui, GuanShen, Liu, XiuYing, Xu, Kai, Wang, Meng, Zhang, XinXin, Jiang, LiYuan, Li, Ang, Yan, Ying, Lai, WeiYi, Sun, BaoFa, Jiang, GuiBin, Wang, HaiLin, Tong, WeiMin, Li, Wei, Wang, XiuJie, Yang, YunGui, Zhou, Qi. METTL3-mediated m6A modification is required for cerebellar development. PLOS BIOLOGY[J]. 2018, 16(6): https://doaj.org/article/ac22537f22f14d259073b36f082d0530.
[50] Danni Wu, Weiyi Lai, Cong Lyu, Haiying Hang, Hailin Wang. UHPLC-Q-TOF/MS detection of UV-induced TpT dimeric lesions in genomic DNA. Journal of Chromatography B. 2018, 1096: 135-142, http://ir.rcees.ac.cn/handle/311016/41079.
[51] Wu, Danni, Lai, Weiyi, Lyu, Cong, Hang, Haiying, Wang, Hailin. UHPLC-Q-TOF/MS detection of UV-induced TpT dimeric lesions in genomic DNA. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2018, 1096: 135-142, http://ir.rcees.ac.cn/handle/311016/41079.
[52] Hailin Wang. 5-methylcytosine promotes mRNA export – NSUN2 as the methyltransferases and ALYREF as an m5C reader. Cell Research. 2017, [53] Yin, Ruichuan, Mo, Jiezhen, Dai, Jiayin, Wang, Hailin. Nickel(II) Inhibits Tet-Mediated 5-Methylcytosine Oxidation by High Affinity Displacement of the Cofactor Iron(II). ACS CHEMICAL BIOLOGY[J]. 2017, 12(6): 1494-1498, http://ir.rcees.ac.cn/handle/311016/39369.
[54] Wu Danni, Liu Baodong, Yin Junfa, Xu Tian, Zhao Shuli, Xu Qun, Chen Xi, Wang Hailin. Detection of 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of oxidative damage in peripheral leukocyte DNA by UHPLC–MS/MS. Journal of Chromatography B[J]. 2017, 1064: 1-6, http://dx.doi.org/10.1016/j.jchromb.2017.08.033.
[55] Zhao, Bailin, Zhang, Dapeng, Li, Chengmin, Yuan, Zheng, Yu, Fangzhi, Zhong, Shangwei, Jiang, Guibin, Yang, YunGui, Le, X Chris, Weinfeld, Michael, Zhu, Ping, Wang, Hailin. ATPase activity tightly regulates RecA nucleofilaments to promote homologous recombination. CELL DISCOVERY[J]. 2017, 3: 16053-, http://dx.doi.org/10.1038/celldisc.2016.53.
[56] Liu, Baodong, Liu, Xiaoling, Lai, Weiyi, Wang, Hailin. Metabolically Generated Stable Isotope-Labeled Deoxynucleoside Code for Tracing DNA N-6-Methyladenine in Human Cells. ANALYTICAL CHEMISTRY[J]. 2017, 89(11): 6203-6210, http://ir.rcees.ac.cn/handle/311016/39361.
[57] Zhong, Shangwei, Li, Zhe, Jiang, Ting, Li, Xiangjun, Wang, Hailin. Immunofluorescence Imaging Strategy for Evaluation of the Accessibility of DNA 5-Hydroxymethylcytosine in Chromatins. ANALYTICAL CHEMISTRY[J]. 2017, 89(11): 5703-5707, http://ir.rcees.ac.cn/handle/311016/39337.
[58] Li, Cuiping, Liu, Baodong, Zhong, Shangwei, Wang, Hailin. MEK inhibitor PD0325901 and vitamin C synergistically induce hypomethylation of mouse embryonic stem sells. ONCOTARGET[J]. 2016, 7(26): 39730-39739, http://ir.rcees.ac.cn/handle/311016/35890.
[59] Yin, Junfa, Xu, Tian, Zhang, Ning, Wang, Hailin. Three-Enzyme Cascade Bioreactor for Rapid Digestion of Genomic DNA into Single Nucleosides. ANALYTICAL CHEMISTRY[J]. 2016, 88(15): 7730-7737, http://dx.doi.org/10.1021/acs.analchem.6b01682.
[60] Zhang, Guoqiang, Huang, Hua, Liu, Di, Cheng, Ying, Liu, Xiaoling, Zhang, Wenxin, Yin, Ruichuan, Zhang, Dapeng, Zhang, Peng, Liu, Jianzhao, Li, Chaoyi, Liu, Baodong, Luo, Yuewan, Zhu, Yuanxiang, Zhang, Ning, He, Shunmin, He, Chuan, Wang, Hailin, Chen, Dahua. N-6-Methyladenine DNA Modification in Drosophila. CELL[J]. 2015, 161(4): 893-906, http://dx.doi.org/10.1016/j.cell.2015.04.018.
[61] Liu, Shengquan, Zhang, Dapeng, Wang, Hailin. Transient Isotachophoresis Focusing of DNA and DNA-Protein Complexes Is Essentially Enhanced by Spontaneously Dissolved Aerial Carbon Dioxide in Electrolytes. ANALYTICAL CHEMISTRY[J]. 2015, 87(1): 554-560, http://dx.doi.org/10.1021/ac504173b.
[62] Zhang, Dapeng, Fu, Rong, Zhao, Qiang, Rong, Haiqin, Wang, Hailin. Nanoparticles-Free Fluorescence Anisotropy Amplification Assay for Detection of RNA Nucleotide-Cleaving DNAzyme Activity. ANALYTICAL CHEMISTRY[J]. 2015, 87(9): 4903-4909, http://ir.rcees.ac.cn/handle/311016/32628.
[63] Yin, Ruichuan, Mo, Jiezhen, Lu, Meiling, Wang, Hailin. Detection of Human Urinary 5-Hydroxymethylcytosine by Stable Isotope Dilution HPLC-MS/MS Analysis. ANALYTICAL CHEMISTRY[J]. 2015, 87(3): 1846-1852, http://dx.doi.org/10.1021/ac5038895.
[64] Zhao, Bailin, Yang, Ying, Wang, Xiaoli, Chong, Zechen, Yin, Ruichuan, Song, ShuHui, Zhao, Chao, Li, Cuiping, Huang, Hua, Sun, BaoFa, Wu, Danni, Jin, KangXuan, Song, Maoyong, Zhu, BenZhan, Jiang, Guibin, Danielsen, Jannie M Rendtlew, Xu, GuoLiang, Yang, YunGui, Wang, Hailin. Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism. NUCLEIC ACIDS RESEARCH[J]. 2014, 42(3): 1593-1605, http://www.irgrid.ac.cn/handle/1471x/936521.
[65] Zhao, Chao, Wang, Hailin, Zhao, Bailin, Li, Cuiping, Yin, Ruichuan, Song, Maoyong, Liu, Baodong, Liu, Zhen, Jiang, Guibin. Boronic acid-mediated polymerase chain reaction for gene- and fragment-specific detection of 5-hydroxymethylcytosine. NUCLEIC ACIDS RESEARCH[J]. 2014, 42(9): http://www.irgrid.ac.cn/handle/1471x/936401.
[66] Zou, Dandan, Zhang, Dapeng, Liu, Shengquan, Zhao, Bailin, Wang, Hailin. Interplay of Binding Stoichiometry and Recognition Specificity for the Interaction of MBD2b Protein and Methylated DNA Revealed by Affinity Capillary Electrophoresis Coupled with Laser-Induced Fluorescence Analysis. ANALYTICAL CHEMISTRY[J]. 2014, 86(3): 1775-1782, http://www.irgrid.ac.cn/handle/1471x/936470.
[67] Yin, Ruichuan, Liu, Shengquan, Zhao, Chao, Lu, Meiling, Tang, Moonshong, Wang, Hailin. An Ammonium Bicarbonate-Enhanced Stable Isotope Dilution UHPLC-MS/MS Method for Sensitive and Accurate Quantification of Acrolein-DNA Adducts in Human Leukocytes. ANALYTICAL CHEMISTRY[J]. 2013, 85(6): 3190-3197, http://www.irgrid.ac.cn/handle/1471x/844429.
[68] Liu, Shengquan, Zhao, Bailin, Zhang, Dapeng, Li, Cuiping, Wang, Hailin. Imaging of Nonuniform Motion of Single DNA Molecules Reveals the Kinetics of Varying-Field Isotachophoresis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2013, 135(12): 4644-4647, https://www.webofscience.com/wos/woscc/full-record/WOS:000317032000018.
[69] Yin, Ruichuan, Mao, ShiQing, Zhao, Bailin, Chong, Zechen, Yang, Ying, Zhao, Chao, Zhang, Dapeng, Huang, Hua, Gao, Juan, Li, Zheng, Jiao, Yan, Li, Cuiping, Liu, Shengquan, Wu, Danni, Gu, Weikuan, Yang, YunGui, Xu, GuoLiang, Wang, Hailin. Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2013, 135(28): 10396-10403, http://dx.doi.org/10.1021/ja4028346.
[70] Song, Maoyong, Zeng, Luzhe, Hong, Xianjun, Meng, Zihui, Yin, Junfa, Wang, Hailin, Liang, Yong, Jiang, Guibin. Polyvinyl Pyrrolidone Promotes DNA Cleavage by a ROS-Independent and Depurination Mechanism. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2013, 47(6): 2886-2891, http://www.irgrid.ac.cn/handle/1471x/844430.
[71] Hailin Wang. Potent DNA damage by polyhalogenated quinones and H₂O₂ via a metal-independent and Intercalation-enhanced oxidation mechanism.. Scientific Reports. 2013, [72] Zhang, Dapeng, Zhao, Qiang, Zhao, Bailin, Wang, Hailin. Fluorescence Anisotropy Reduction of Allosteric Aptamer for Sensitive and Specific Protein Signaling. ANALYTICAL CHEMISTRY[J]. 2012, 84(7): 3070-3074, http://www.irgrid.ac.cn/handle/1471x/901126.
[73] Zhao, Chao, Yin, Ruichuan, Yin, Junfa, Zhang, Dapeng, Wang, Hailin. Capillary Monolithic Bioreactor of Immobilized Snake Venom Phosphodiesterase for Mass Spectrometry Based Oligodeoxynucleotide Sequencing. ANALYTICAL CHEMISTRY[J]. 2012, 84(2): 1157-1164, http://www.irgrid.ac.cn/handle/1471x/901142.
[74] Zhang, Dapeng, Shen, Hujun, Li, Guohui, Zhao, Bailin, Yu, Anchi, Zhao, Qiang, Wang, Hailin. Specific and Sensitive Fluorescence Anisotropy Sensing of Guanine-Quadruplex Structures via a Photoinduced Electron Transfer Mechanism. ANALYTICAL CHEMISTRY[J]. 2012, 84(18): 8088-8094, http://www.irgrid.ac.cn/handle/1471x/901101.
[75] Hailin Wang. Size-dependent toxicity of nano-C60 aggregates: More sensitive indication by apoptosis-related Bax translocation in cultured human cells.. Environm. Sci. & Technol.. 2012, [76] Chen, Zhilan, Lu, Meiling, Zhuang, Guoqiang, Wang, Hailin. Enhanced Bacterial Biosensor for Fast and Sensitive Detection of Oxidatively DNA Damaging Agents. ANALYTICAL CHEMISTRY[J]. 2011, 83(9): 3248-3251, http://dx.doi.org/10.1021/ac200426x.
[77] Zhang, Dapeng, Lu, Meiling, Wang, Hailin. Fluorescence Anisotropy Analysis for Mapping Aptamer-Protein Interaction at the Single Nucleotide Level. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2011, 133(24): 9188-9191, https://www.webofscience.com/wos/woscc/full-record/WOS:000291915100015.
[78] Li, Tao, Zhang, Dapeng, Luo, Wenru, Lu, Meiling, Wang, Zhixin, Song, Yuling, Wang, Hailin. Metal Cation Mediated-Capillary Electrophoresis of Nucleic Acids. ANALYTICAL CHEMISTRY[J]. 2010, 82(2): 487-490, http://www.irgrid.ac.cn/handle/1471x/964236.
[79] Song Maoyong, Jiang Guibin, Yin Junfa, Wang Hailin. Inhibition of polymerase activity by pristine fullerene nanoparticles can be mitigated by abundant proteins. CHEMICAL COMMUNICATIONS[J]. 2010, 46(9): 1404-1406, http://www.irgrid.ac.cn/handle/1471x/964224.
[80] Wang, Zhixin, Wang, Xiaoli, Liu, Shengquan, Yin, Junfa, Wang, Hailin. Fluorescently Imaged Particle Counting Immunoassay for Sensitive Detection of DNA Modifications. ANALYTICAL CHEMISTRY[J]. 2010, 82(23): 9901-9908, http://www.irgrid.ac.cn/handle/1471x/964213.
[81] Hailin Wang. Fluorescence polarization combined capillary electrophoresis immunoassay for rapid and sensitive detection of genomic DNA methylation. Anal. Chem.. 2009, [82] Wang, Zhixin, Lu, Meiling, Wang, Xiaoli, Yin, Ruichuan, Song, Yuling, Le, X Chris, Wang, Hailin. Quantum Dots Enhanced Ultrasensitive Detection of DNA Adducts. ANALYTICAL CHEMISTRY[J]. 2009, 81(24): 10285-10289, http://www.irgrid.ac.cn/handle/1471x/971935.
[83] Li, Tao, Wang, Hailin. Organic Osmolyte Mediated Kinetic Capillary Electrophoresis for Study of Protein-DNA Interactions. ANALYTICAL CHEMISTRY[J]. 2009, 81(5): 1988-1995, http://www.irgrid.ac.cn/handle/1471x/971919.
[84] Wang, Hailin, Lu, Meiling, Tang, MoonShong, Van Houten, Bennett, Ross, J B Alexander, Weinfeld, Michael, Le, X Chris. DNA wrapping is required for DNA damage recognition in the Escherichia coli DNA nucleotide excision repair pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2009, 106(31): 12849-12854, http://www.irgrid.ac.cn/handle/1471x/971862.
[85] Wang, Chao, Feng, Feng, Wang, Zhixin, Li, Tao, Le, X Chris, Wang, Hailin. Synthesis and Characterization of DNA Fluorescent Probes Containing a Single Site-Specific Stereoisomer of anti-Benzoapyrene Diol Epoxide-N-2-dG. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2009, 22(4): 676-682, http://www.irgrid.ac.cn/handle/1471x/971949.
[86] Hailin Wang. A microdialysis sampling method for evaluation of binding kinetics of small molecules to macromolecules. Anal. Chem.. 2008, 
发表著作
(1) 现代毒理学, A Textbook of Mordern Toxicology, 中国科学出版社, 2011-06, 第 2 作者

科研活动

   
科研项目
( 1 ) 国家杰出青年基金, 主持, 国家级, 2012-01--2015-12
( 2 ) 毛细管电泳-双光子荧光偏振单分子检测装置, 主持, 国家级, 2014-01--2017-12
( 3 ) DNA损伤分析方法与生物效应研究及专用仪器开发”, 主持, 国家级, 2012-01--2015-12
( 4 ) 针对蛋白质-核酸相互作用研究的单分子荧光偏振分析方法学与技术, 主持, 国家级, 2015-01--2019-12
( 5 ) 污染物与生物大分子的交互作用, 主持, 部委级, 2014-06--2018-12

指导学生

已指导学生

刘淑芳  博士研究生  083001-环境科学  

王智鑫  博士研究生  083001-环境科学  

冯峰  博士研究生  083001-环境科学  

李涛  博士研究生  083001-环境科学  

王超  硕士研究生  083001-环境科学  

陈芝兰  博士研究生  083001-环境科学  

宋玉玲  硕士研究生  083001-环境科学  

王晓利  博士研究生  083001-环境科学  

章大鹏  博士研究生  083001-环境科学  

刘胜权  博士研究生  083001-环境科学  

赵超  博士研究生  083001-环境科学  

尹瑞川  博士研究生  083001-环境科学  

李文静  硕士研究生  083001-环境科学  

邹丹丹  博士研究生  083001-环境科学  

李翠平  博士研究生  083001-环境科学  

赵柏林  博士研究生  070302-分析化学  

黄华  博士研究生  083001-环境科学  

刘保东  博士研究生  083001-环境科学  

刘晓玲  博士研究生  070302-分析化学  

刘迪  硕士研究生  077601-环境科学  

吴丹妮  博士研究生  083001-环境科学  

赖玮毅  博士研究生  083001-环境科学  

朱会宇  博士研究生  083001-环境科学  

现指导学生

袁征  博士研究生  070302-分析化学  

陈政  博士研究生  083001-环境科学  

任云  博士研究生  083001-环境科学  

莫杰珍  博士研究生  070302-分析化学  

李瑶  硕士研究生  071010-生物化学与分子生物学  

刘艳  博士研究生  071007-遗传学  

景昶衡  硕士研究生  077601-环境科学  

余方志  博士研究生  070302-分析化学  

孙境蔚  硕士研究生  071010-生物化学与分子生物学  

郑婧  硕士研究生  070302-分析化学  

吕聪  博士研究生  070302-分析化学