基本信息
卫涛涛  男  博导  中国科学院生物物理研究所
电子邮件: weitt@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号生物物理所3505室
邮政编码: 100101

研究领域

线粒体是细胞的能量代谢中心,也是细胞命运决定的调控中枢之一。在正常生理条件下,线粒体网络不断发生动态变化、实现稳态维持,通过进行能量代谢与物质代谢维持细胞生命活动;在特定病理条件下,线粒体稳态被破坏,直接影响线粒体的功能,对生命过程造成显著影响。本课题组长期聚焦膜与细胞生物学的研究,结合结构生物学、单分子生物物理学、蛋白组学及修饰组学等技术手段发现了多种维持线粒体稳态的蛋白质机器,解析了它们影响细胞命运决定的分子机制,并揭示了它们参与代谢性疾病及恶性肿瘤发生发展的重要作用;还构建了一系列靶向线粒体、调控细胞能量代谢并有效阻遏肿瘤的纳米生物材料。作为通讯作者及第一作者发表SCI论文50余篇。论文总引用4000余次,H因子32。在中国科学院大学主讲的《细胞生物学》课程被认定为首批国家级一流本科课程、北京市高校课程思政示范课程。

招生信息

研究组重视综合培养研究生的科研能力及人文素养,学术氛围严谨求真,团队文化宽松和谐,研究生多次获得奖励

2011年,赵凯,中国科学院三好学生标兵

2013年,周合江,国家奖学金

2014年,周合江,保罗生物科技奖学金

2016年,杜康,国家奖学金

2018年,贺小龙,所长奖学金

2018年,胡昊,所长奖学金

2020年,赵军程,唐立新奖学金

2020年,张叶,中国科学院大学大学生奖学金

2020年,张佳龄,所长奖学金

2020年,李洪宇,所长奖学金

2021年,肖敏,所长奖学金

招生专业
071010-生物化学与分子生物学
招生方向
生物膜动态变化、稳态维持与重大疾病

教育背景

1996-09--1999-06   中国科学院生物物理研究所   博士
1993-09--1996-07   湖北省化学研究所   硕士
1989-09--1993-06   华中理工大学(现华中科技大学)   学士
学历

博士研究生毕业

学位
理学博士

工作经历

   
工作简历
2008-03~现在, 中国科学院生物物理研究所, 研究员
2001-02~2008-03,中国科学院生物物理研究所, 副研究员
1999-07~2001-02,中国科学院生物物理研究所, 助理研究员
社会兼职
2017-12-31-今,生物化学与生物物理进展, 常务编委
2017-11-01-今,中国生物物理学会, 理事
2015-12-31-今,中国生物物理学会膜生物学分会, 理事、秘书长
2015-01-01-今,中国抗癌协会纳米肿瘤学专业委员会, 委员
2012-10-30-今,中国生物物理学会自由基生物学分会, 理事
2004-12-01-今,中华预防医学会自由基预防医学专业委员会, 常务委员

教授课程

科研论文写作-2班
细胞生物学

专利与奖励

国家发明专利:一种用于检测丙二酰辅酶A的分子探针,ZL201810641532.1

国家发明专利:提高肝脏SIRT5蛋白活性和/或表达量的物质在治疗急性心肌梗死中的应用,ZL202110175793.0

奖励信息
(1) 北京市课程思政教学名师, 省级, 2022
(2) 中国科学院大学领雁金奖-引航奖, , 研究所(学校), 2021
(3) 国家级一流本科课程, , 国家级, 2020
(4) 江西省自然科学奖, 二等奖, 省级, 2020
(5) 中国科学院大学本科生优秀课程, 研究所(学校), 2020
(6) 中国科学院大学生命科学学院精品课程, 研究所(学校), 2019

出版信息

   
发表论文
[1] 卫涛涛, 陈佺, 徐涛, 陈晔光. 中国细胞器互作研究的进展和趋势. 中国科学:生命科学[J]. 2022, 1-4, [2] Wang, Yongwei, Xiao, Min, Zhang, Yu, Huo, Yanwu, Wei, Taotao. Chloroquine inhibits deferoxamine-induced ferritinophagy and potentiates the cytotoxicity of chemotherapy drugs in lung cancer cells.. 生物化学与生物物理进展[J]. 2022, 48(2): 370-380, [3] Zhou, Boda, Xiao, Min, Hu, Hao, Pei, Xiaoxia, Xue, Yajun, Miao, Guobin, Wang, Jifeng, Li, Wanqi, Du, Yipeng, Zhang, Ping, Wei, Taotao. Cardioprotective Role of SIRT5 in Response to Acute Ischemia Through a Novel Liver-Cardiac Crosstalk Mechanism. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2021, 9: 687559-, [4] Hua, Chaoju, Dai, Fei, Deng, Yao, Lu, Junwan, Zhou, Ningning, Li, Wanqi, Zhang, Ye, Huang, Kate, Liu, Yongzhang, Lu, Bin, Wei, Taotao. Aberrantly Upregulated EF4 Is Crucial for The Proliferation and Migration of Bladder Urothelial Carcinoma Cells via Orchestration of Mitochondrial Oxidative Phosphorylation. 生物化学与生物物理进展[J]. 2021, 48(3): 317-327, [5] Zhang, Jialing, Yan, Liang, Wei, Peng, Zhou, Ruyi, Hua, Chaoju, Xiao, Min, Tu, Yaping, Gu, Zhanjun, Wei, Taotao. PEG-GO@XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to-mesenchymal transition. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2021, 895: [6] Wang, Sheng, Xie, Yan, Huo, Yanwu, Li, Yan, Abel, Peter W, Jiang, Haihong, Zou, Xiaohan, Jiao, Haizhan, Kuang, Xiaolin, Wolff, Dennis W., Huang, Youguo, Casale, Thomas B., Panettieri, Reynold A., Jr., Wei, Taotao, Cao, Zhengyu, Tu, Yaping. Airway relaxation mechanisms and structural basis of osthole to improve lung function in asthma. SCIENCE SIGNALING[J]. 2020, 13(659): eaax0273-, [7] Dong, Yaqiong, Stewart, Tessandra, Bai, Lidan, Li, Xue, Xu, Ting, Iliff, Jeffrey, Shi, Min, Zheng, Danfeng, Yuan, Lan, Wei, Taotao, Yang, Xiaoda, Zhang, Jing. Coniferaldehyde attenuates Alzheimer's pathology via activation of Nrf2 and its targets. THERANOSTICS[J]. 2020, 10(1): 179-200, [8] Zhang, Jialing, Hua, Chaoju, Zhang, Yu, Wei, Peng, Tu, Yaping, Wei, Taotao. KAP1-associated transcriptional inhibitory complex regulates C2C12 myoblasts differentiation and mitochondrial biogenesis via miR-133a repression. CELL DEATH & DISEASE[J]. 2020, 11(9): 732-, [9] Zhou, Boda, Du, Yipeng, Xue, Yajun, Miao, Guobin, Wei, Taotao, Zhang, Ping. Identification of Malonylation, Succinylation, and Glutarylation in Serum Proteins of Acute Myocardial Infarction Patients. PROTEOMICS CLINICAL APPLICATIONS[J]. 2020, 14(1): 1900103-, [10] Du, Yipeng, Hu, Hao, Pei, Xiaoxia, Du, Kang, Wei, Taotao. Genetically Encoded FapR-NLuc as a Biosensor to Determine Malonyl-CoA in Situ at Subcellular Scales. BIOCONJUGATE CHEMISTRY[J]. 2019, 30(3): 826-832, [11] Ma, Li, Hu, Shuxin, He, Xiaolong, Yang, Na, Chen, Licui, Yang, Chenguang, Ye, Fangfu, Wei, Taotao, Li, Ming. Detection of tBid Oligomerization and Membrane Permeabilization by Graphene-Based Single-Molecule Surface-Induced Fluorescence Attenuation. NANO LETTERS[J]. 2019, 19(10): 6937-6944, [12] Zhang, Yini, Li, Tao, Zhang, Lihui, Shangguan, Fugen, Shi, Guizhi, Wu, Xun, Cui, Ya, Wang, Xie, Wang, Xi, Liu, Yongzhang, Lu, Bin, Wei, Taotao, Wang, Chihchen, Wang, Lei. Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1 alpha and protein disulfide isomerase suppresses the progression of cervical cancer. EBIOMEDICINE[J]. 2019, 41: 408-419, [13] Xu, Yang, Ren, Jinqi, He, Xiaolong, Chen, Han, Wei, Taotao, Feng, Wei. YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. AUTOPHAGY[J]. 2019, 15(6): 1017-1030, [14] Wei, Peng, Xie, Yan, Abel, Peter W, Huang, Yapei, Ma, Qin, Li, Linghai, Hao, Junfeng, Wolff, Dennis W, Wei, Taotao, Tu, Yaping. Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis. Cell Death & Disease[J]. 2019, 10(9): 1-17, [15] Zhang, Yinlong, Wei, Jingyan, Xu, Jiaqi, Leong, Wei Sun, Liu, Guangna, Ji, Tianjiao, Cheng, Zhiqiang, Wang, Jing, Lang, Jiayan, Zhao, Ying, You, Linhao, Zha, Xiao, Wei, Taotao, Anderson, Greg J, Qi, Sheng, Kong, Jing, Nie, Guangjun, Li, Suping. Suppression of Tumor Energy Supply by Liposomal Nanoparticle-Mediated Inhibition of Aerobic Glycolysis. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 10(3): 2347-2353, [16] Du, Yipeng, Hu, Hao, Hua, Chaoju, Du, Kang, Wei, Taotao. Tissue distribution, subcellular localization, and enzymatic activity analysis of human SIRT5 isoforms. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2018, 503(2): 763-769, [17] Li, Feng, Li, Yiye, Yang, Xiao, Han, Xuexiang, Jiao, Yang, Wei, Taotao, Yang, Dayong, Xu, Huaping, Nie, Guangjun. Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine: Affecting Cellular Energy Metabolism. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(9): 2377-2382, [18] Du, Yipeng, Hu, Hao, Qu, Saisi, Wang, Jifeng, Hua, Chaoju, Zhang, Jialing, We, Peng, He, Xiaolong, Hao, Junfeng, Liu, Pingsheng, Yang, Fuquan, Li, Tingting, Wei, Taotao. SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice. EBIOMEDICINE[J]. 2018, 36: 347-357, [19] Zhu, Ping, Liu, Yongzhang, Zhang, Fenglin, Bai, Xiufeng, Chen, Zilei, Shangguan, Fugen, Zhang, Bo, Zhang, Lingyun, Chen, Qianqian, Xie, Deyao, Lan, Linhua, Xue, Xiangdong, Liang, XingJie, Lu, Bin, Wei, Taotao, Qin, Yan. Human Elongation Factor 4 Regulates Cancer Bioenergetics by Acting as a Mitochondrial Translation Switch. CANCER RESEARCH[J]. 2018, 78(11): 2813-2824, [20] Du, Yipeng, Zhai, Zichao, Li, Ying, Lu, Ming, Cai, Tanxi, Zhou, Bo, Huang, Lei, Wei, Taotao, Li, Tingting. Prediction of Protein Lysine Acylation by Integrating Primary Sequence Information with Multiple Functional Features. JOURNAL OF PROTEOME RESEARCH[J]. 2016, 15(12): 4234-4244, [21] Yang, Na, Chen, Qianqian, He, Xiaolong, Zhao, Xingyu, Wei, Taotao. ESeroS-GS Protects Neuronal Cells from Oxidative Stress by Stabilizing Lysosomes. MOLECULES[J]. 2016, 21(6): [22] Zhang, Bo, Wei, Peng, Zhou, Zhixiang, Wei, Taotao. Interactions of graphene with mammalian cells: Molecular mechanisms and biomedical insights. ADVANCED DRUG DELIVERY REVIEWS[J]. 2016, 105: 145-162, [23] Wong, ChuuYun A, Jiang, Haihong, Abel, Peter W, Scofield, Margaret A, Xie, Yan, Wei, Taotao, Tu, Yaping. Phorbol myristate acetate suppresses breast cancer cell growth via down-regulation of P-Rex1 expression. PROTEIN & CELL[J]. 2016, 7(6): 445-449, [24] Zhang, Bo, Wang, Jing, Huang, Zhen, Wei, Peng, Liu, Ying, Hao, Junfeng, Zhao, Lijing, Zhang, Fenglin, Tu, Yaping, Wei, Taotao. Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer. ONCOTARGET[J]. 2015, 6(42): 44495-44508, [25] Zhao, Qian, Chen, Deliang, Liu, Pingsheng, Wei, Taotao, Zhang, Fang, Ding, Wenjun. Oxidovanadium(IV) sulfate-induced glucose uptake in HepG2 cells through IR/Akt pathway and hydroxyl radicals. JOURNAL OF INORGANIC BIOCHEMISTRY[J]. 2015, 149: 39-44, [26] Du, Yipeng, Cai, Tanxi, Li, Tingting, Xue, Peng, Zhou, Bo, He, Xiaolong, Wei, Peng, Liu, Pingsheng, Yang, Fuquan, Wei, Taotao. Lysine Malonylation Is Elevated in Type 2 Diabetic Mouse Models and Enriched in Metabolic Associated Proteins. MOLECULAR & CELLULAR PROTEOMICS[J]. 2015, 14(1): 227-236, [27] Zhang, Bo, Chu, Wei, Wei, Peng, Liu, Ying, Wei, Taotao. Xanthohumol induces generation of reactive oxygen species and triggers apoptosis through inhibition of mitochondrial electron transfer chain complex I. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2015, 89: 486-497, [28] Zhou, Teng, Yu, Meifang, Zhang, Bo, Wang, Liming, Wu, Xiaochun, Zhou, Hejiang, Du, Yipeng, Hao, Junfeng, Tu, Yaping, Chen, Chunying, Wei, Taotao. Inhibition of Cancer Cell Migration by Gold Nanorods: Molecular Mechanisms and Implications for Cancer Therapy. ADVANCED FUNCTIONAL MATERIALS[J]. 2014, 24(44): 6922-6932, [29] Zhao, Lijing, Zhao, Xingyu, Zhao, Kai, Wei, Peng, Fang, Yi, Zhang, Fenglin, Zhang, Bo, Ogata, Kazumi, Mori, Akitane, Wei, Taotao. The α-tocopherol derivative ESeroS-GS induces cell death and inhibits cell motility of breast cancer cells through the regulation of energy metabolism. European Journal of Pharmacology[J]. 2014, 745: 98-107, [30] Zhou, Hejiang, Zhang, Bo, Zheng, Jiajia, Yu, Meifang, Zhou, Teng, Zhao, Kai, Jia, Yanxia, Gao, Xingfa, Chen, Chunying, Wei, Taotao. The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respiration. BIOMATERIALS[J]. 2014, 35(5): 1597-1607, [31] Zhou, Teng, Zhang, Bo, Wei, Peng, Du, Yipeng, Zhou, Hejiang, Yu, Meifang, Yan, Liang, Zhang, Wendi, Nie, Guangjun, Chen, Chunying, Tu, Yaping, Wei, Taotao. Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets. BIOMATERIALS[J]. 2014, 35(37): 9833-9843, [32] Du, Yipeng, Wei, Taotao. Inputs and outputs of insulin receptor. PROTEIN & CELL[J]. 2014, 5(3): 203-213, [33] Chen, Qianqian, Zhang, Juan, Zhao, Kai, Li, Wei, Miao, Qi, Sun, Yang, Zhao, Xingyu, Wei, Taotao, Yang, Fuyu. Lysosomal chymotrypsin induces mitochondrial fission in apoptotic cells by proteolytic activation of calcineurin. PROTEIN & CELL[J]. 2014, 5(8): 643-647, [34] Jiang, Pengtao, Huang, Zhen, Zhao, Hong, Wei, Taotao. Hydrogen peroxide impairs autophagic flux in a cell model of nonalcoholic fatty liver disease. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2013, 433(4): 408-414, [35] Duan, Wenjuan, Zhou, Juefei, Li, Wei, Zhou, Teng, Chen, Qianqian, Yang, Fuyu, Wei, Taotao. Plasma membrane calcium ATPase 4b inhibits nitric oxide generation through calcium-induced dynamic interaction with neuronal nitric oxide synthase. Protein & Cell[J]. 2013, 4(4): 286-298, [36] Barrera, Lawrence N, Cassidy, Aedin, Wang, Wei, Wei, Taotao, Belshaw, Nigel J, Johnson, Ian T, BrigeliusFlohe, Regina, Bao, Yongping. TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH[J]. 2012, 1823(10): 1914-1924, [37] Li, Yang, Liu, Ying, Fu, Yujian, Wei, Taotao, Le Guyader, Laurent, Gao, Ge, Liu, RuShi, Chang, YanZhong, Chen, Chunying. The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways. BIOMATERIALS[J]. 2012, 33(2): 402-411, http://dx.doi.org/10.1016/j.biomaterials.2011.09.091.
[38] Zhao, Kai, Zhou, Hejiang, Zhao, Xingyu, Wolff, Dennis W., Tu, Yaping, Liu, Huili, Wei, Taotao, Yang, Fuyu. Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis. Journal of Lipid Research[J]. 2012, 53(10): 2102-2114, [39] Zhou, Hejiang, Zhao, Kai, Li, Wei, Yang, Na, Liu, Ying, Chen, Chunying, Wei, Taotao. The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-κB-related signaling pathways. Biomaterials[J]. 2012, 33(29): 6933-6942, [40] 卫涛涛. 质膜钙离子ATP酶. 生物物理学报[J]. 2012, 28(7): 549-564, [41] 段文娟, 卫涛涛. 神经型一氧化氮合酶的活性调控. 生物物理学报[J]. 2012, 28(4): 278-286, [42] Wang, Liming, Liu, Ying, Li, Wei, Jiang, Xiumei, Ji, Yinglu, Wu, Xiaochun, Xu, Ligeng, Qiu, Yang, Zhao, Kai, Wei, Taotao, Li, Yufeng, Zhao, Yuliang, Chen, Chunying. Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy. NANO LETTERS[J]. 2011, 11(2): 772-780, [43] Duan, Wenjuan, Zhou, Juefei, Zhang, Shen, Zhao, Kai, Zhao, Lijing, Ogata, Kazumi, Sakaue, Takahiro, Mori, Akitane, Wei, Taotao. ESeroS-GS modulates lipopolysaccharide-induced macrophage activation by impairing the assembly of TLR-4 complexes in lipid rafts. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH[J]. 2011, 1813(5): 772-783, [44] Li, Wei, Zhao, Lina, Wei, Taotao, Zhao, Yuliang, Chen, Chunying. The inhibition of death receptor mediated apoptosis through lysosome stabilization following internalization of carboxyfullerene nanoparticles. Biomaterials[J]. 2011, 32(16): 4030-4041, [45] 赵凯, 卫涛涛. 溶酶体与细胞凋亡. 生命科学[J]. 2011, 23(11): 1063-1068, [46] Zhao, Kai, Zhao, Xingyu, Tu, Yaping, Miao, Qi, Cao, Dongxu, Duan, Wenjuan, Sun, Yang, Wang, Jincheng, Wei, Taotao, Yang, Fuyu. Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid. Cellular and Molecular Life Sciences[J]. 2010, 67(15): 2665-2678, [47] Zhao, Kai, Huang, Zhen, Lu, Hongling, Zhou, Juefei, Wei, Taotao. Induction of inducible nitric oxide synthase increases the production of reactive oxygen species in RAW264.7 macrophages. BIOSCIENCE REPORTS[J]. 2010, 30(4): 233-241, [48] Xie, Yan, Wolff, Dennis W, Wei, Taotao, Wang, Bo, Deng, Caishu, Kirui, Joseph K, Jiang, Haihong, Qin, Jianbing, Abel, Peter W, Tu, Yaping. Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4. CANCER RESEARCH[J]. 2009, 69(14): 5743-5751, [49] Miao, Qi, Sun, Yang, Wei, Taotao, Zhao, Xingyu, Zhao, Kai, Yan, Ling, Zhang, Xujia, Shu, Hongjun, Yang, Fuyu. Chymotrypsin B cached in rat liver lysosomes and involved in apoptotic regulation through a mitochondrial pathway. Journal of Biological Chemistry[J]. 2008, 283(13): 8218-8228, [50] Zhou, Juefei, Zhang, Shen, Zhao, Xingyu, Wei, Taotao. Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-beta(1-42). JOURNAL OF PINEAL RESEARCH[J]. 2008, 45(2): 157-165, 
发表著作
(1) 纳米酶学, Nanozymology, Springer Nature, 2020-01, 第 3 作者

指导学生

已指导学生

赵兴宇  博士研究生  071010-生物化学与分子生物学  

段文娟  博士研究生  071011-生物物理学  

戴斐  博士研究生  071010-生物化学与分子生物学  

张佳龄  博士研究生  071010-生物化学与分子生物学  

王永伟  博士研究生  071010-生物化学与分子生物学  

现指导学生

张瑀  硕士研究生  085238-生物工程  

肖敏  博士研究生  071010-生物化学与分子生物学  

张叶  硕士研究生  071010-生物化学与分子生物学  

赵军程  硕士研究生  071010-生物化学与分子生物学  

张凯  博士研究生  071010-生物化学与分子生物学  

任凤蕊  博士研究生  071010-生物化学与分子生物学  

李洪宇  博士研究生  071010-生物化学与分子生物学  

邓其夫  硕士研究生  071010-生物化学与分子生物学  

李佳运  硕士研究生  071010-生物化学与分子生物学