基本信息

孙蕾  博士 中国科学院微生物研究所
电子邮件: sunlei362@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号
邮政编码: 100101

研究领域

流感病毒致病机理、抗病毒天然免疫及抗病毒、抗炎症制品研究。


招生信息

   
招生专业
100103-病原生物学
招生方向
流感病毒感染与免疫,抗病毒药物研究

教育背景

2000-07--2005-06   扬州大学   博士
1996-09--2000-06   山东农业大学   学士

工作经历

   
工作简历
2019-10~现在, 中国科学院微生物研究所, 项目研究员
2011-08~2012-11,美国康奈尔大学医学院, 访问助理教授
2009-06~现在, 中国科学院微生物研究所, 副研究员
2005-07~2009-06,中国科学院微生物研究所, 助理研究员

教授课程

医学病毒学

出版信息

   
发表论文
[1] Wenxian Yang, Xiaoyuan Bai, Xiaohan Luan, Jie Min, Xiaodong Tian, Heqiao Li, Huizi Li, Wenqiang Sun, Wei Liu, Wenhui Fan, Wenjun Liu, Lei Sun. Delicate regulation of IL-1β-mediated inflammation by cyclophilin A. Cell Reports[J]. 2022, 38(11): https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00249-2.
[2] Fan, Wenhui, Cao, Ying, Jiao, Pengtao, Yu, Ping, Zhang, He, Chen, Teng, Zhou, Xintao, Qi, Yu, Sun, Lei, Liu, Di, Zhu, Hongfei, Liu, Wenjun, Hu, Rongliang, Li, Jing. Synergistic effect of the responses of different tissues against African swine fever virus. TRANSBOUNDARY AND EMERGING DISEASES. 2021, [3] Sun, Wenqiang, He, Lihong, Zhang, He, Tian, Xiaodong, Bai, Zhihua, Sun, Lei, Yang, Limin, Jia, Xiaojuan, Bi, Yuhai, Luo, Tingrong, Cheng, Gong, Fan, Wenhui, Liu, Wenjun, Li, Jing. The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2021, 6(1): http://dx.doi.org/10.1038/s41392-021-00750-w.
[4] Luan, Xiaohan, Yang, Wenxian, Bai, Xiaoyuan, Li, Heqiao, Li, Huizi, Fan, Wenhui, Zhang, He, Liu, Wenjun, Sun, Lei. Cyclophilin A is a key positive and negative feedback regulator within interleukin-6 trans-signaling pathway. FASEB JOURNAL[J]. 2021, 35(11): [5] Bai, Xiaoyuan, Yang, Wenxian, Luan, Xiaohan, Li, Huizi, Li, Heqiao, Tian, Deyu, Fan, Wenhui, Li, Jing, Wang, Beinan, Liu, Wenjun, Sun, Lei. Induction of cyclophilin A by influenza A virus infection facilitates group A Streptococcus coinfection. CELL REPORTS[J]. 2021, 35(7): http://dx.doi.org/10.1016/j.celrep.2021.109159.
[6] 田璐, 刘文军, 孙蕾. 亲环素A对冠状病毒复制的影响及其抑制剂的抗病毒作用研究进展. 生物工程学报[J]. 2020, 36(4): 605-611, http://lib.cqvip.com/Qikan/Article/Detail?id=7101828508.
[7] 田璐, 焦鹏涛, 侯力丹, 李芸, 宋正宇, 刘文军, 范文辉, 孙蕾. RIG-I敲除293T细胞系的建立及其对B型流感病毒复制的影响. 生物工程学报. 2020, 36(1): 109-121, http://lib.cqvip.com/Qikan/Article/Detail?id=7100862750.
[8] 孙蕾. Nucleoprotein phosphorylation site (Y385) mutation confers temperature sensitivity to influenza Avirus due to impaired nucleoprotein oligomerization at a lower temperature. SCIENCE CHINA Life Sciences. 2020, [9] Zheng, Weinan, Fan, Wenhui, Zhang, Shuang, Jiao, Pengtao, Shang, Yingli, Cui, Liang, Mahesutihan, Madina, Li, Jing, Wang, Dayan, Gao, George Fu, Sun, Lei, Liu, Wenjun. Naproxen Exhibits Broad Anti-influenza Virus Activity in Mice by Impeding Viral Nucleoprotein Nuclear Export. CELL REPORTS[J]. 2019, 27(6): 1875-+, http://dx.doi.org/10.1016/j.celrep.2019.04.053.
[10] Cui, Liang, Zheng, Weinan, Li, Minghui, Bai, Xiaoyuan, Yang, Wenxian, Li, Jing, Fan, Wenhui, Gao, George Fu, Sun, Lei, Liu, Wenjun. Phosphorylation Status of Tyrosine 78 Residue Regulates the Nuclear Export and Ubiquitination of Influenza A Virus Nucleoprotein. FRONTIERS IN MICROBIOLOGY[J]. 2019, 10: https://doaj.org/article/a35b91df1ab941fba1c70438baea24f8.
[11] Cui, Liang, Mahesutihan, Madina, Zheng, Weinan, Meng, Lijun, Fan, Wenhui, Li, Jing, Ye, Xin, Liu, Wenjun, Sun, Lei. CDC25B promotes influenza A virus replication by regulating the phosphorylation of nucleoprotein. VIROLOGY[J]. 2018, 525: 40-47, http://dx.doi.org/10.1016/j.virol.2018.09.005.
[12] 刘文军, 刘薇, 陈璨, 范文辉, 张鹤, 刘文军, 孙蕾. 胞外亲环素A对炎症发生的影响及其抗体在抑制炎症反应中的作用. 生物工程学报[J]. 2018, 34(1): 90-101, http://lib.cqvip.com/Qikan/Article/Detail?id=674348273.
[13] Li, Yun, Sun, Lei, Zheng, Weinan, Mahesutihan, Madina, Li, Jing, Bi, Yuhai, Wang, Heran, Liu, Wenjun, Luo, Ting Rong. Phosphorylation and dephosphorylation of threonine 188 in nucleoprotein is crucial for the replication of influenza A virus. VIROLOGY[J]. 2018, 520: 30-38, http://dx.doi.org/10.1016/j.virol.2018.05.002.
[14] Chen, Can, Fan, Wenhui, Li, Jing, Zheng, Weinan, Zhang, Shuang, Yang, Limin, Liu, Di, Liu, Wenjun, Sun, Lei. A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY[J]. 2018, 8: http://202.127.146.157/handle/2RYDP1HH/5226.
[15] Mahesutihan, Madina, Zheng, Weinan, Cui, Liang, Li, Yun, Jiao, Pengtao, Yang, Wenxian, Liu, Wei, Li, Jing, Fan, Wenhui, Yang, Limin, Liu, Wenjun, Sun, Lei. CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus. VIROLOGICA SINICA[J]. 2018, 33(5): 440-448, http://lib.cqvip.com/Qikan/Article/Detail?id=6100074074.
[16] Li, Jing, Zheng, Weinan, Hou, Lidan, Chen, Can, Fan, Wenhui, Qu, Hongren, Jiang, Jingwen, Liu, Jinhua, Gao, George F, Zhou, Jiyong, Sun, Lei, Liu, Wenjun. Differential nucleocytoplasmic shuttling of the nucleoprotein of influenza a viruses and association with host tropism. CELLULAR MICROBIOLOGY[J]. 2017, 19(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000398678000004.
[17] Liu, Wei, Li, Jing, Zheng, Weinan, Shang, Yingli, Zhao, Zhendong, Wang, Shanshan, Bi, Yuhai, Zhang, Shuang, Xu, Chongfeng, Duan, Ziyuan, Zhang, Lianfeng, Wang, Yue L, Jiang, Zhengfan, Liu, Wenjun, Sun, Lei. Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses. ELIFE[J]. 2017, 6: https://doaj.org/article/6555b1c46ad8457eb97313f044b02231.
[18] 任丽倩, 刘薇, 李文博, 刘文军, 孙蕾. 脊椎动物Cyclophilin A肽基脯氨酰顺反异构酶活性及遗传变异分析. 遗传[J]. 2016, 38(8): 736-745, http://lib.cqvip.com/Qikan/Article/Detail?id=669770243.
[19] Wenjun Liu. Threonine 80 Phosphorylation of Non-Structural Protein NS1 Regulates the Replication of Influenza A Virus by Reducing the Binding Affinity with RIG-I. Cellular Microbiology. 2016,