流感等病毒的适应性进化与免疫逃逸机制、病毒重症感染及炎症疾病的调控机制、抗病毒/抗炎症制剂研究

   

100103-病原生物学

流感病毒感染与免疫，抗病毒药物研究

2000-07--2005-06   扬州大学   博士
1996-09--2000-06   山东农业大学   学士

   

2019-10~现在, 中国科学院微生物研究所, 项目研究员
2011-08~2012-11,美国康奈尔大学医学院, 访问助理教授
2009-06~现在, 中国科学院微生物研究所, 副研究员
2005-07~2009-06,中国科学院微生物研究所, 助理研究员

医学病毒学

   

（1） The binding of extracellular cyclophilin A to ACE2 and CD147 triggers psoriasis-like inflammation, Journal of Autoimmunity, 2024, 
（2） The nuclear localization signal of monkeypox virus protein P2 orthologue is critical for inhibition of IRF3-mediated innate immunity, Emerging Microbes & Infections, 2024, 
（3） The extracellular cyclophilin A-integrin ��2 complex as a therapeutic target of viral pneumonia, Molecular Therapy, 2024, 
（4） PROTAC targeting cyclophilin A controls virus-induced cytokine storm, ISCIENCE, 2023, 第 8 作者  通讯作者
（5） SARS-CoV-2 nonstructural protein 6 triggers endoplasmic reticulum stress-induced autophagy to degrade STING1, AUTOPHAGY, 2023, 第 14 作者  通讯作者
（6） Recombinant porcine interferon cocktail delays the onset and lessens the severity of African swine fever, ANTIVIRAL RESEARCH, 2023, 第 10 作者  通讯作者
（7） Delicate regulation of IL-1 beta-mediated inflammation by cyclophilin A, CELL REPORTS, 2022, 第 12 作者  通讯作者
（8） Cyclosporine A Regulates Influenza A Virus-induced Macrophages Polarization and Inflammatory Responses by Targeting Cyclophilin A, FRONTIERS IN IMMUNOLOGY, 2022, 第 8 作者  通讯作者
（9） Influenza A and B Virus-Triggered Epithelial���Mesenchymal Transition Is Relevant to the Binding Ability of NA to Latent TGF-��, FRONTIERS IN MICROBIOLOGY, 2022, 第 8 作者  通讯作者
（10） The Cross-Protective Immunity Landscape Among Different SARS-CoV-2 Variant RBDs, FRONTIERS IN IMMUNOLOGY, 2022, 第 8 作者  通讯作者
（11） Nucleoprotein phosphorylation site(Y385)mutation confers temperature sensitivity to influenza A virus due to impaired nucleoprotein oligomerization at a lower temperature, Nucleoprotein phosphorylation site (Y385) mutation confers temperature sensitivity to influenza A virus due to impaired nucleoprotein oligomerization at a lower temperature, SCIENCE CHINA-LIFE SCIENCES, 2021, 第 8 作者  通讯作者
（12） Synergistic effect of the responses of different tissues against African swine fever virus, TRANSBOUNDARY AND EMERGING DISEASES, 2021, 第 9 作者
（13） The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice, The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 6 作者
（14） Cyclophilin A is a key positive and negative feedback regulator within interleukin-6 trans-signaling pathway, FASEB JOURNAL, 2021, 第 9 作者  通讯作者
（15） Induction of cyclophilin A by influenza A virus infection facilitates group A Streptococcus coinfection, CELL REPORTS, 2021, 第 11 作者  通讯作者
（16） 亲环素A对冠状病毒复制的影响及其抑制剂的抗病毒作用研究进展, Role of cyclophilin A during coronavirus replication and the antiviral activities of its inhibitors, 生物工程学报, 2020, 第 3 作者
（17） RIG-I敲除293T细胞系的建立及其对B型流感病毒复制的影响, Establishment of RIG-I knockout 293T cell line and its effect on the replication of influenza B virus, 生物工程学报, 2020, 第 8 作者
（18） Naproxen Exhibits Broad Anti-influenza Virus Activity in Mice by Impeding Viral Nucleoprotein Nuclear Export, CELL REPORTS, 2019, 第 11 作者  通讯作者
（19） Phosphorylation Status of Tyrosine 78 Residue Regulates the Nuclear Export and Ubiquitination of Influenza A Virus Nucleoprotein, FRONTIERS IN MICROBIOLOGY, 2019, 第 9 作者  通讯作者
（20） CDC25B promotes influenza A virus replication by regulating the phosphorylation of nucleoprotein, VIROLOGY, 2018, 第 9 作者  通讯作者
（21） 胞外亲环素A对炎症发生的影响及其抗体在抑制炎症反应中的作用, Effect of extracellular cyclophilin A on inflammatory response and anti-inflammatory activity of antibody against cyclophilin A, 生物工程学报, 2018, 第 7 作者  通讯作者
（22） Phosphorylation and dephosphorylation of threonine 188 in nucleoprotein is crucial for the replication of influenza A virus, VIROLOGY, 2018, 第 2 作者  通讯作者
（23） A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus, FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2018, 第 9 作者  通讯作者
（24） CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus, CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus, Virologica Sinica, 2018, 第 12 作者  通讯作者
（25） Differential nucleocytoplasmic shuttling of the nucleoprotein of influenza a viruses and association with host tropism., CELLULAR MICROBIOLOGY, 2017, 第 11 作者  通讯作者
（26） Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses, ELIFE, 2017, 第 15 作者  通讯作者
（27） Threonine 80 Phosphorylation of Non-Structural Protein NS1 Regulates the Replication of Influenza A Virus by Reducing the Binding Affinity with RIG-I, Cellular Microbiology, 2016, 
（28） 脊椎动物Cyclophilin A肽基脯氨酰顺反异构酶活性及遗传变异分析, Peptidylprolyl cis/trans isomerase activity and molecular evolution of vertebrate Cyclophilin A, 遗传, 2016, 第 5 作者
（29） Novel genetic reassortants in H9N2 influenza A viruses and their diverse pathogenicity to mice, VIROLOGYJOURNAL, 2011, 第 10 作者  通讯作者