基本信息
饶子和  男  博导  中国科学院生物物理研究所
电子邮件: raozh@nankai.edu.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码:

招生信息

   
招生专业
071010-生物化学与分子生物学
招生方向
人类感染相关或具有重要生理功能的蛋白质与病毒的三维结构研究,以及创新药物治疗的开发
蛋白质结构、功能与创新药物

教育背景

1985-07--1989-07   澳大利亚墨尔本大学   博士
1979-07--1982-07   中国科学院生物物理研究所   硕士
1973-06--1977-06   中国科技大学   本科

工作经历

   
工作简历
2006-05~2011-01,南开大学, 校长
2003-03~2007-03,中国科学院生物物理研究所, 所长
1996-07~现在, 清华大学, 教授
1992-07~1996-07,牛津大学, 高级研究员
1989-07~1992-07,英国牛津大学, 博士后
1982-07~1985-07,中国科学院生物物理研究所, 助理研究员
1977-07~1979-07,中国科学院生物物理研究所, 助理研究员
社会兼职
2013-12-31-2017-12-30,国际纯粹与应用生物物理联合会(IUPAB ), 主席
2010-01-01-今,Protein & Cell, 主编
2006-01-01-今,中国生物物理学会, 理事长

专利与奖励

   
奖励信息
(1) 杰出学术领袖奖, 特等奖, 国家级, 2009
(2) 谈家桢生命科学成就奖, 特等奖, 国家级, 2008
(3) 第三世界科学院最高奖-第里雅斯特科学奖, 特等奖, 其他, 2006
(4) 何梁何利奖, 一等奖, 国家级, 2003
(5) 长江学者特聘教授, 特等奖, 部委级, 2000
(6) 求是杰出青年学者奖, 一等奖, 国家级, 1999

出版信息

   
发表论文
[1] Tang, Yanting, Mu, An, Zhang, Yuying, Zhou, Shan, Wang, Weiwei, Lai, Yuezheng, Zhou, Xiaoting, Liu, Fengjiang, Yang, Xiuna, Gong, Hongri, Wang, Quan, Rao, Zihe. Cryo-EM structure of Mycobacterium smegmatis DyP-loaded encapsulin. Proceedings of the National Academy of Sciences of the United States of America[J]. 2021, 118(16): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072242/.
[2] Weiwei Wang, Yan Gao, Yanting Tang, Xiaoting Zhou, Yuezheng Lai, Shan Zhou, Yuying Zhang, Xiuna Yang, Fengjiang Liu, Luke W Guddat, Quan Wang, Zihe Rao, Hongri Gong. Cryo-EM structure of mycobacterial cytochrome bd reveals two oxygen access channels. Nature Communications[J]. 2021, 12(1): http://dx.doi.org/10.1038/s41467-021-24924-w.
[3] Huiling Kang, Jingyuan Cong, Chenlong Wang, Wenxin Ji, Yuhui Xin, Ying Qian, Xuemei Li, Yutao Chen, Zihe Rao. Structural basis for recognition and regulation of arenavirus polymerase L by Z protein. Nature Communications[J]. 2021, 12(1): http://dx.doi.org/10.1038/s41467-021-24458-1.
[4] Linhua Tai, Guoliang Zhu, Minnan Yang, Lei Cao, Xiaorui Xing, Guoliang Yin, Chun Chan, Chengfeng Qin, Zihe Rao, Xiangxi Wang, Fei Sun, Yun Zhu. Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein. Proceedings of the National Academy of Sciences of the United States of America[J]. 2021, 118(48): [5] Zhou, Xiaoting, Gao, Yan, Wang, Weiwei, Yang, Xiaolin, Yang, Xiuna, Liu, Fengjiang, Tang, Yanting, Lam, Sin Man, Shui, Guanghou, Yu, Lu, Tian, Changlin, Guddat, Luke W, Wang, Quan, Rao, Zihe, Gong, Hongri. Architecture of the mycobacterial succinate dehydrogenase with a membrane-embedded Rieske FeS cluster. Proceedings of the National Academy of Sciences of the United States of America[J]. 2021, 118(15): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8054011/.
[6] Yang, Haitao, Rao, Zihe. Structural biology of SARS-CoV-2 and implications for therapeutic development. NATURE REVIEWS MICROBIOLOGYnull. 2021, 19(11): 685-700, http://dx.doi.org/10.1038/s41579-021-00630-8.
[7] Shan Zhou, Weiwei Wang, Xiaoting Zhou, Yuying Zhang, Yuezheng Lai, Yanting Tang, Jinxu Xu, Dongmei Li, Jianping Lin, Xiaolin Yang, Ting Ran, Hongming Chen, Luke W Guddat, Quan Wang, Yan Gao, Zihe Rao, Hongri Gong, David Drew, Volker Dtsch. Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. eLife[J]. 2021, 10: http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA202112115573314ZK.
[8] Zhu, Ling, Deng, YongQiang, Zhang, RongRong, Cui, Zhen, Sun, ChunYun, Fan, ChangFa, Xing, Xiaorui, Huang, Weijin, Chen, Qi, Zhang, NaNa, Ye, Qing, Cao, TianShu, Wang, Nan, Wang, Lei, Cao, Lei, Wang, Huiyu, Kong, Desheng, Ma, Juan, Luo, Chunxia, Zhang, Yanjing, Nie, Jianhui, Sun, Yao, Lv, Zhe, Shaw, Neil, Li, Qianqian, Li, XiaoFeng, Hu, Junjie, Xie, Liangzhi, Rao, Zihe, Wang, Youchun, Wang, Xiangxi, Qin, ChengFeng. Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2. NATIONAL SCIENCE REVIEW[J]. 2021, 8(3): http://dx.doi.org/10.1093/nsr/nwaa297.
[9] Yan, Liming, Yang, Yunxiang, Li, Mingyu, Zhang, Ying, Zheng, Litao, Ge, Ji, Huang, Yucen C, Liu, Zhenyu, Wang, Tao, Gao, Shan, Zhang, Ran, Huang, Yuanyun Y, Guddat, Luke W, Gao, Yan, Rao, Zihe, Lou, Zhiyong. Coupling of N7-methyltransferase and 3 '-5 ' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. CELL[J]. 2021, 184(13): 3474-+, http://dx.doi.org/10.1016/j.cell.2021.05.033.
[10] Wu, Jiqin, Wang, Haofeng, Liu, Qiaojie, Li, Rui, Gao, Yan, Fang, Xiang, Zhong, Yao, Wang, Meihua, Wang, Quan, Rao, Zihe, Gong, Peng. Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex. CELL REPORTS[J]. 2021, 37(4): 109882-109882, http://dx.doi.org/10.1016/j.celrep.2021.109882.
[11] Wang, Nan, Chen, Wenyuan, Zhu, Ling, Zhu, Dongjie, Feng, Rui, Wang, Jialing, Zhu, Bin, Zhang, Xinzheng, Chen, Xiaoqing, Liu, Xianjie, Yan, Runbin, Ni, Dongyao, Zhou, Grace Guoying, Liu, Hongrong, Rao, Zihe, Wang, Xiangxi. Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation. PROTEIN & CELLnull. 2020, 11(5): 366-373, http://lib.cqvip.com/Qikan/Article/Detail?id=7102116302.
[12] Wang, Lin, Wu, Juehui, Li, Jun, Yang, Hua, Tang, Tianqi, Liang, Haijiao, Zuo, Mianyong, Wang, Jie, Liu, Haipeng, Liu, Feng, Chen, Jianxia, Liu, Zhonghua, Wang, Yang, Peng, Cheng, Wu, Xiangyang, Zheng, Ruijuan, Huang, Xiaochen, Ran, Yajun, Rao, Zihe, Ge, Baoxue. Host-mediated ubiquitination of a mycobacterial protein suppresses immunity. NATURE[J]. 2020, 577(7792): 682-+, http://dx.doi.org/10.1038/s41586-019-1915-7.
[13] Gao, Yan, Yan, Liming, Huang, Yucen, Liu, Fengjiang, Zhao, Yao, Cao, Lin, Wang, Tao, Sun, Qianqian, Ming, Zhenhua, Zhang, Lianqi, Ge, Ji, Zheng, Litao, Zhang, Ying, Wang, Haofeng, Zhu, Yan, Zhu, Chen, Hu, Tianyu, Hua, Tian, Zhang, Bing, Yang, Xiuna, Li, Jun, Yang, Haitao, Liu, Zhijie, Xu, Wenqing, Guddat, Luke W, Wang, Quan, Lou, Zhiyong, Rao, Zihe. Structure of the RNA-dependent RNA polymerase from COVID-19 virus. SCIENCE[J]. 2020, 368(6492): 779-+, http://dx.doi.org/10.1126/science.abb7498.
[14] Kang Wang, Binyang Zheng, Li Zhang, Lunbiao Cui, Xuan Su, Qian Zhang, Zhenxi Guo, Yu Guo, Wei Zhang, Ling Zhu, Fengcai Zhu, Zihe Rao, Xiangxi Wang. Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-18250-w.
[15] Lu, Zuokun, Wang, Han, Zhang, Aili, Liu, Xiang, Zhou, Weihong, Yang, Cheng, Guddat, Luke, Yang, Haitao, Schofield, Christopher J, Rao, Zihe. Structures of Mycobacterium tuberculosis Penicillin-Binding Protein 3 in Complex with Five beta-Lactam Antibiotics Reveal Mechanism of Inactivation. MOLECULAR PHARMACOLOGY[J]. 2020, 97(4): 287-294, https://www.webofscience.com/wos/woscc/full-record/WOS:000517815400006.
[16] Lonhienne, Thierry, Low, Yu Shang, Garcia, Mario D, Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M, Fraser, James A, McGeary, Ross P, West, Nicholas P, Landsberg, Michael J, Rao, Zihe, Schenk, Gerhard, Guddat, Luke W. Structures of fungal and plant acetohydroxyacid synthases. NATURE[J]. 2020, 586(7828): 317-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000567779800001.
[17] Wang, Panpan, Liu, Lu, Liu, Aijun, Yan, Liming, He, Yong, Shen, Shu, Hu, Mingxu, Guo, Yu, Liu, Haiguang, Liu, Chuang, Lu, Yinying, Wang, Peiyi, Deng, Fei, Rao, Zihe, Lou, Zhiyong. Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation. NATURE MICROBIOLOGY[J]. 2020, 5(6): 864-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000528980200002.
[18] Jin, Zhenming, Du, Xiaoyu, Xu, Yechun, Deng, Yongqiang, Liu, Meiqin, Zhao, Yao, Zhang, Bing, Li, Xiaofeng, Zhang, Leike, Peng, Chao, Duan, Yinkai, Yu, Jing, Wang, Lin, Yang, Kailin, Liu, Fengjiang, Jiang, Rendi, Yang, Xinglou, You, Tian, Liu, Xiaoce, Yang, Xiuna, Bai, Fang, Liu, Hong, Liu, Xiang, Guddat, Luke W, Xu, Wenqing, Xiao, Gengfu, Qin, Chengfeng, Shi, Zhengli, Jiang, Hualiang, Rao, Zihe, Yang, Haitao. Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors. NATURE[J]. 2020, 582(7811): 289-+, http://dx.doi.org/10.1038/s41586-020-2223-y.
[19] Liu, Fengjiang, Liang, Jingxi, Zhang, Bing, Gao, Yan, Yang, Xiuna, Hu, Tianyu, Yang, Haitao, Xu, Wenqing, Guddat, Luke W, Rao, Zihe. Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC. SCIENCE ADVANCES[J]. 2020, 6(44): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608808/.
[20] Yang, Xiaolin, Hu, Tianyu, Yang, Xiuna, Xu, Wenqing, Yang, Haitao, Guddat, Luke W, Zhang, Bing, Rao, Zihe. Structural Basis for the Inhibition of Mycobacterial MmpL3 by NITD-349 and SPIRO. JOURNAL OF MOLECULAR BIOLOGY[J]. 2020, 432(16): 4426-4434, http://dx.doi.org/10.1016/j.jmb.2020.05.019.
[21] Yu, Caiting, Zhao, Jinghua, Yan, Liming, Qi, Yuanbo, Guo, Xiangyang, Lou, Zhiyong, Hu, Junjie, Rao, Zihe. Structural insights into G domain dimerization and pathogenic mutation of OPA1. JOURNAL OF CELL BIOLOGY[J]. 2020, 219(7): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337494/.
[22] Zhang, Min, Wang, Ying, He, Wanli, Sun, Yao, Guo, Yan, Zhong, Weilong, Gao, Qiang, Liao, Mingyang, Wang, Xiangxi, Cai, Yan, Guo, Yu, Rao, Zihe. Design, Synthesis, and Evaluation of Novel Enterovirus 71 Inhibitors as Therapeutic Drug Leads for the Treatment of Human Hand, Foot, and Mouth Disease. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 63(3): 1233-1244, https://www.webofscience.com/wos/woscc/full-record/WOS:000514221700021.
[23] Chen, Xiaobo, Chen, Jiayue, Yan, Bing, Zhang, Wei, Guddat, Luke W, Liu, Xiang, Rao, Zihe. Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(28): 16324-16332, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368279/.
[24] Zhang, Lu, Zhao, Yao, Gao, Yan, Wu, Lijie, Gao, Ruogu, Zhang, Qi, Wang, Yinan, Wu, Chengyao, Wu, Fangyu, Gurcha, Sudagar S, Veerapen, Natacha, Batt, Sarah M, Zhao, Wei, Qin, Ling, Yang, Xiuna, Wang, Manfu, Zhu, Yan, Zhang, Bing, Bi, Lijun, Zhang, Xianen, Yang, Haitao, Guddat, Luke W, Xu, Wenqing, Wang, Quan, Li, Jun, Besra, Gurdyal S, Rao, Zihe. Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol. SCIENCE[J]. 2020, 368(6496): 1211-+, http://dx.doi.org/10.1126/science.aba9102.
[25] Hongri Gong, Yan Gao, Xiaoting Zhou, Yu Xiao, Weiwei Wang, Yanting Tang, Shan Zhou, Yuying Zhang, Wenxin Ji, Lu Yu, Changlin Tian, Sin Man Lam, Guanghou Shui, Luke W Guddat, LuetLok Wong, Quan Wang, Zihe Rao. Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-18011-9.
[26] Yang, Yunxiang, Yang, Pan, Wang, Nan, Chen, Zhonghao, Su, Dan, Zhou, Z Hong, Rao, Zihe, Wang, Xiangxi. Architecture of the herpesvirus genome-packaging complex and implications for DNA translocation. PROTEIN & CELL[J]. 2020, 11(5): 339-351, http://lib.cqvip.com/Qikan/Article/Detail?id=7102116300.
[27] Zhang, Bing, Li, Jun, Yang, Xiaolin, Wu, Lijie, Zhang, Jia, Yang, Yang, Zhao, Yao, Zhang, Lu, Yang, Xiuna, Yang, Xiaobao, Cheng, Xi, Liu, Zhijie, Jiang, Biao, Jiang, Hualiang, Guddat, Luke W, Yang, Haitao, Rao, Zihe. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. CELL[J]. 2019, 176(3): 636-+, http://dx.doi.org/10.1016/j.cell.2019.01.003.
[28] Cao, Lin, Chen, Jizheng, Wang, Yaxin, Yang, Yuting, Qing, Jie, Rao, Zihe, Chen, Xinwen, Lou, Zhiyong. Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy. PROTEIN & CELL[J]. 2019, 10(3): 178-195, http://lib.cqvip.com/Qikan/Article/Detail?id=7001589015.
[29] Ran Zhang, Guangxue Xu, Lin Cao, Zixian Sun, Yong He, Mengtian Cui, Yuna Sun, Shentao Li, Huapeng Li, Lan Qin, Mingxu Hu, Zhengjia Yuan, Zipei Rao, Wei Ding, Zihe Rao, Zhiyong Lou. Divergent engagements between adeno-associated viruses with their cellular receptor AAVR. Nature Communications[J]. 2019, 10(1): 1-11, http://dx.doi.org/10.1038/s41467-019-11668-x.
[30] Zhang, Ran, Cao, Lin, Cui, Mengtian, Sung, Zixian, Hu, Mingxu, Zhang, Rouxuan, Stuarts, William, Zhao, Xiaochu, Yang, Zirui, Li, Xueming, Sun, Yuna, Li, Shentao, Ding, Wei, Lou, Zhiyong, Rao, Zihe. Adeno-associated virus 2 bound to its cellular receptor AAVR. NATURE MICROBIOLOGY[J]. 2019, 4(4): 675-682, https://www.webofscience.com/wos/woscc/full-record/WOS:000461999200020.
[31] Wang, Nan, Zhao, Dongming, Wang, Jialing, Zhang, Yangling, Wang, Ming, Gao, Yan, Li, Fang, Wang, Jingfei, Bu, Zhigao, Rao, Zihe, Wang, Xiangxi. Architecture of African swine fever virus and implications for viral assembly. SCIENCE[J]. 2019, 366(6465): 640-+, [32] Manfu Wang, Xiangyang Guo, Xiuna Yang, Bing Zhang, Jie Ren, Aijun Liu, Yajun Ran, Bing Yan, Fang Chen, Luke W Guddat, Junjie Hu, Jun Li, Zihe Rao. Mycobacterial dynamin-like protein IniA mediates membrane fission. Nature Communications[J]. 2019, 10(1): 1-13, http://dx.doi.org/10.1038/s41467-019-11860-z.
[33] Ma, Dan, Wang, Zhizhi, Merrikh, Christopher N, Lang, Kevin S, Lu, Peilong, Li, Xin, Merrikh, Houra, Rao, Zihe, Xu, Wenqing. Crystal structure of a membrane-bound O-acyltransferase. NATURE[J]. 2018, 562(7726): 286-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000446920400057.
[34] Qiu, Xiaodi, Lei, Yingfeng, Yang, Pan, Gao, Qiang, Wang, Nan, Cao, Lei, Yuan, Shuai, Huang, Xiaofang, Deng, Yongqiang, Ma, Wenyu, Ding, Tianbing, Zhang, Fanglin, Wu, Xingan, Hu, Junjie, Liu, ShanLu, Qin, Chengfeng, Wang, Xiangxi, Xu, Zhikai, Rao, Zihe. Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies. NATURE MICROBIOLOGY[J]. 2018, 3(3): 287-294, https://www.webofscience.com/wos/woscc/full-record/WOS:000425846200009.
[35] Jialing Wang, Shuai Yuan, Dongjie Zhu, Hao Tang, Nan Wang, Wenyuan Chen, Qiang Gao, Yuhua Li, Junzhi Wang, Hongrong Liu, Xinzheng Zhang, Zihe Rao, Xiangxi Wang. Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/e0d44ce22fca47ef9b1e63e0558a8d9f.
[36] Cao, Lin, Zhang, Ran, Liu, Tingting, Sun, Zixian, Hu, Mingxu, Sun, Yuna, Cheng, Lingpeng, Guo, Yu, Fu, Sheng, Hu, Junjie, Li, Xiangmin, Yu, Chengqi, Wang, Hanyang, Chen, Huanchun, Li, Xueming, Fry, Elizabeth E, Stuart, David I, Qian, Ping, Lou, Zhiyong, Rao, Zihe. Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(51): 13087-13092, https://www.webofscience.com/wos/woscc/full-record/WOS:000453529800073.
[37] Qingqing Zhang, Huijuan Liu, Xiang Liu, Dunquan Jiang, Bingjie Zhang, Hongliang Tian, Cheng Yang, Luke W Guddat, Haitao Yang, Kaixia Mi, Zihe Rao. Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target. 蛋白质与细胞:英文版. 2018, 9(11): 971-975, http://lib.cqvip.com/Qikan/Article/Detail?id=676820275.
[38] Zhang, Qingqing, Liu, Huijuan, Liu, Xiang, Jiang, Dunquan, Zhang, Bingjie, Tian, Hongliang, Yang, Cheng, Guddat, Luke W, Yang, Haitao, Mi, Kaixia, Rao, Zihe. Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target. PROTEIN & CELLnull. 2018, 9(11): 971-975, http://lib.cqvip.com/Qikan/Article/Detail?id=676820275.
[39] 郝博威, 张永艳, 韩旭, 李鑫, 王宁宁, 饶子和. 小立碗藓ACL1的晶体制备. 南开大学学报:自然科学版[J]. 2018, 51(6): 48-53, http://lib.cqvip.com/Qikan/Article/Detail?id=6100122887.
[40] Zhang, Lianqi, Li, Lei, Yan, Liming, Ming, Zhenhua, Jia, Zhihui, Lou, Zhiyong, Rao, Zihe. Structural and Biochemical Characterization of Endoribonuclease Nsp15 Encoded by Middle East Respiratory Syndrome Coronavirus. JOURNAL OF VIROLOGY[J]. 2018, 92(22): https://www.webofscience.com/wos/woscc/full-record/WOS:000448576900010.
[41] Yuan, Shuai, Wang, Jialing, Zhu, Dongjie, Wang, Nan, Gao, Qiang, Chen, Wenyuan, Tang, Hao, Wang, Junzhi, Zhang, Xinzheng, Liu, Hongrong, Rao, Zihe, Wang, Xiangxi. Cryo-EM structure of a herpesvirus capsid at 3.1 angstrom. SCIENCE[J]. 2018, 360(6384): 48-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000429263100042.
[42] Gong, Hongri, Li, Jun, Xu, Ao, Tang, Yanting, Ji, Wenxin, Gao, Ruogu, Wang, Shuhui, Yu, Lu, Tian, Changlin, Li, Jingwen, Yen, HsinYung, Lam, Sin Man, Shui, Guanghou, Yang, Xiuna, Sun, Yuna, Li, Xuemei, Jia, Minze, Yang, Cheng, Jiang, Biao, Lou, Zhiyong, Robinson, Carol V, Wong, LuetLok, Guddat, Luke W, Sun, Fei, Wang, Quan, Rao, Zihe. An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. SCIENCE[J]. 2018, 362(6418): 1020-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000451609000036.
[43] Wang, Jiao, Okkeri, Juha, Pavic, Karolina, Wang, Zhizhi, Kauko, Otto, Halonen, Tuuli, Sarek, Grzegorz, Ojala, Paivi M, Rao, Zihe, Xu, Wenqing, Westermarck, Jukka. Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56. EMBO REPORTS[J]. 2017, 18(3): 437-450, https://www.webofscience.com/wos/woscc/full-record/WOS:000395061000013.
[44] Wang, Xiangxi, Zhu, Ling, Dang, Minghao, Hu, Zhongyu, Gao, Qiang, Yuan, Shuai, Sun, Yao, Zhang, Bo, Ren, Jingshan, Kotecha, Abhay, Walter, Thomas S, Wang, Junzhi, Fry, Elizabeth E, Stuart, David I, Rao, Zihe. Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 114(4): 770-775, https://www.webofscience.com/wos/woscc/full-record/WOS:000392597000055.
[45] Kotecha, Abhay, Wang, Quan, Dong, Xianchi, Ilca, Serban L, Ondiviela, Marina, Zihe, Rao, Seago, Julian, Charleston, Bryan, Fry, Elizabeth E, Abrescia, Nicola G A, Springer, Timothy A, Huiskonen, Juha T, Stuart, David I. Rules of engagement between alpha v beta 6 integrin and foot-and-mouth disease virus. NATURE COMMUNICATIONS[J]. 2017, 8: https://www.webofscience.com/wos/woscc/full-record/WOS:000401834600001.
[46] Xiangxi Wang, ShiHua Li, Ling Zhu, QingGong Nian, Shuai Yuan, Qiang Gao, Zhongyu Hu, Qing Ye, XiaoFeng Li, DongYang Xie, Neil Shaw, Junzhi Wang, Thomas S Walter, Juha T Huiskonen, Elizabeth E Fry, ChengFeng Qin, David I Stuart, Zihe Rao. Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/ed5e43459e464ee6a6602a849e5c6e81.
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[113] Xu Yueyang, Li Xin, Li Ruiqing, Li Shanshan, Ni Hongqian, Wang Hui, Xu Haijin, Zhou Weihong, Saris Per E J, Yang Wen, Qiao Mingqiang, Rao Zihe. Structure of the nisin leader peptidase NisP revealing a C-terminal autocleavage activity. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY[J]. 2014, 70: 1499-1505, [114] Minghao Dang, Xiangxi Wang, Quan Wang, Yaxin Wang, Jianping Lin, Yuna Sun, Xuemei Li, Liguo Zhang, Zhiyong Lou, Junzhi Wang, Zihe Rao. Molecular mechanism of SCARB2-mediatec attachment and uncoating of EV71. 蛋白质与细胞:英文版. 2014, 692-703, http://lib.cqvip.com/Qikan/Article/Detail?id=662830435.
[115] Zhang, Liang, Duan, Xiaolu, Zhou, Daming, Dong, Zhe, Ji, Kaihua, Meng, Wuyi, Li, Guoqiang, Li, Xin, Yang, Haitao, Ma, Ting, Rao, Zihe. Structural insights into the stabilization of active, tetrameric DszC by its C-terminus. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS[J]. 2014, 82(10): 2733-2743, https://www.webofscience.com/wos/woscc/full-record/WOS:000342849400037.
[116] Ren, Zhilin, Yan, Liming, Zhang, Ning, Guo, Yu, Yang, Cheng, Lou, Zhiyong, Rao, Zihe. The newly emerged SARS-Like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease. PROTEIN & CELL[J]. 2013, 4(4): 248-250, http://www.irgrid.ac.cn/handle/1471x/756653.
[117] Chen, Cheng, Wang, Yaxin, Shan, Chao, Sun, Yuna, Xu, Peng, Zhou, Honggang, Yang, Cheng, Shi, PeiYong, Rao, Zihe, Zhang, Bo, Lou, Zhiyong. Crystal Structure of Enterovirus 71 RNA-Dependent RNA Polymerase Complexed with Its Protein Primer VPg: Implication for a trans Mechanism of VPg Uridylylation. JOURNAL OF VIROLOGY[J]. 2013, 87(10): 5755-5768, http://www.irgrid.ac.cn/handle/1471x/756538.
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[119] Sun, Fei, Zhou, Qiangjun, Pang, Xiaoyun, Xu, Yingzhi, Rao, Zihe. Revealing various coupling of electron transfer and proton pumping in mitochondrial respiratory chain. CURRENT OPINION IN STRUCTURAL BIOLOGY[J]. 2013, 23(4): 526-538, http://dx.doi.org/10.1016/j.sbi.2013.06.013.
[120] Zhang, Yinjie, Li, Le, Liu, Xiang, Dong, Shishang, Wang, Wenming, Huo, Tong, Guo, Yu, Rao, Zihe, Yang, Cheng. Crystal structure of Junin virus nucleoprotein. JOURNAL OF GENERAL VIROLOGY[J]. 2013, 94: 2175-2183, https://www.webofscience.com/wos/woscc/full-record/WOS:000326215000003.
[121] Rao Zihe. Structural analysis of Mycobacterium tuberculosis ATP-binding cassette transporter subunit UgpB reveals specificity for glycerophosphocholine.. 2013, [122] Wang, Lu, Li, Jun, Wang, Xiangxi, Liu, Wu, Zhang, Xuejun C, Li, Xuemei, Rao, Zihe. Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c. PROTEIN & CELL[J]. 2013, 4(8): 628-640, http://www.irgrid.ac.cn/handle/1471x/756650.
[123] Li, Jun, Dong, Yu, Lu, Xingru, Wang, Lu, Peng, Wei, Zhang, Xuejun C, Rao, Zihe. Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6. PROTEIN & CELL[J]. 2013, 4(7): 548-561, http://www.irgrid.ac.cn/handle/1471x/756660.
[124] Ren, Zhilin, Yan, Liming, Zhang, Ning, Guo, Yu, Yang, Cheng, Lou, Zhiyong, Rao, Zihe. The newly emerged SARS-Like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease. PROTEIN & CELL[J]. 2013, 4(4): 248-250, http://www.irgrid.ac.cn/handle/1471x/756653.
[125] Chen, Cheng, Wang, Yaxin, Shan, Chao, Sun, Yuna, Xu, Peng, Zhou, Honggang, Yang, Cheng, Shi, PeiYong, Rao, Zihe, Zhang, Bo, Lou, Zhiyong. Crystal Structure of Enterovirus 71 RNA-Dependent RNA Polymerase Complexed with Its Protein Primer VPg: Implication for a trans Mechanism of VPg Uridylylation. JOURNAL OF VIROLOGY[J]. 2013, 87(10): 5755-5768, http://www.irgrid.ac.cn/handle/1471x/756538.
[126] Ren, Jingshan, Wang, Xiangxi, Hu, Zhongyu, Gao, Qiang, Sun, Yao, Li, Xuemei, Porta, Claudine, Walter, Thomas S, Gilbert, Robert J, Zhao, Yuguang, Axford, Danny, Williams, Mark, McAuley, Katherine, Rowlands, David J, Yin, Weidong, Wang, Junzhi, Stuart, David I, Rao, Zihe, Fry, Elizabeth E. Picornavirus uncoating intermediate captured in atomic detail. NATURE COMMUNICATIONS[J]. 2013, 4: https://www.webofscience.com/wos/woscc/full-record/WOS:000323623600002.
[127] Sun, Fei, Zhou, Qiangjun, Pang, Xiaoyun, Xu, Yingzhi, Rao, Zihe. Revealing various coupling of electron transfer and proton pumping in mitochondrial respiratory chain. CURRENT OPINION IN STRUCTURAL BIOLOGY[J]. 2013, 23(4): 526-538, http://dx.doi.org/10.1016/j.sbi.2013.06.013.
[128] Zhang, Yinjie, Li, Le, Liu, Xiang, Dong, Shishang, Wang, Wenming, Huo, Tong, Guo, Yu, Rao, Zihe, Yang, Cheng. Crystal structure of Junin virus nucleoprotein. JOURNAL OF GENERAL VIROLOGY[J]. 2013, 94: 2175-2183, https://www.webofscience.com/wos/woscc/full-record/WOS:000326215000003.
[129] Rao Zihe. Structural analysis of Mycobacterium tuberculosis ATP-binding cassette transporter subunit UgpB reveals specificity for glycerophosphocholine.. 2013, [130] Wang, Lu, Li, Jun, Wang, Xiangxi, Liu, Wu, Zhang, Xuejun C, Li, Xuemei, Rao, Zihe. Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c. PROTEIN & CELL[J]. 2013, 4(8): 628-640, http://www.irgrid.ac.cn/handle/1471x/756650.
[131] Li, Jun, Dong, Yu, Lu, Xingru, Wang, Lu, Peng, Wei, Zhang, Xuejun C, Rao, Zihe. Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6. PROTEIN & CELL[J]. 2013, 4(7): 548-561, http://www.irgrid.ac.cn/handle/1471x/756660.
[132] Xu, Jiwei, Peng, Wei, Sun, Yao, Wang, Xiangxi, Xu, Yihui, Li, Xuemei, Gao, Guangxia, Rao, Zihe. Structural study of MCPIP1 N-terminal conserved domain reveals a PIN-like RNase. NUCLEIC ACIDS RESEARCH[J]. 2012, 40(14): 6957-6965, http://www.irgrid.ac.cn/handle/1471x/756945.
[133] Guo, Yu, Wang, Wenming, Ji, Wei, Deng, Maping, Sun, Yuna, Zhou, Honggang, Yang, Cheng, Deng, Fei, Wang, Hualin, Hu, Zhihong, Lou, Zhiyong, Rao, Zihe. Crimean-Congo hemorrhagic fever virus nucleoprotein reveals endonuclease activity in bunyaviruses. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 109(13): 5046-5051, http://www.irgrid.ac.cn/handle/1471x/756745.
[134] 冯长根, 程津培, 刘德培, 袁驷, 彭先觉, 钟南山, 许智宏, 姒健敏, 饶子和, 龚克, 杨卫. 建立博士毕业生临时研究岗位制度,缓解承担国家重大科研项目人才紧缺问题. 科技导报. 2012, 30(7): 15-17, http://lib.cqvip.com/Qikan/Article/Detail?id=41337404.
[135] Wang, Xiangxi, Peng, Wei, Ren, Jingshan, Hu, Zhongyu, Xu, Jiwei, Lou, Zhiyong, Li, Xumei, Yin, Weidong, Shen, Xinliang, Porta, Claudine, Walter, Thomas S, Evans, Gwyndaf, Axford, Danny, Owens, Robin, Rowlands, David J, Wang, Junzhi, Stuart, David I, Fry, Elizabeth E, Rao, Zihe. A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2012, 19(4): 424-429, http://www.irgrid.ac.cn/handle/1471x/756710.
[136] Zhang, Wenzheng, Fu, Sheng, Liu, Xuefeng, Zhao, Xuelian, Zhang, Wenchi, Peng, Wei, Wu, Congying, Li, Yuanyuan, Li, Xuemei, Bartlam, Mark, Zeng, ZongHao, Zhan, Qimin, Rao, Zihe. Crystal structure of human Gadd45 gamma reveals an active dimer (vol 2, pg 814, 2011). PROTEIN & CELLnull. 2012, 3(3): 239-239, http://www.irgrid.ac.cn/handle/1471x/756990.
[137] Rao Zihe. Crimean-Congo hemorrhagic fever virus nucleoprotein reveals an endonuclease activity in the Bunyaviruses.. Proc. Natl. Acad. Sci. USA. 2012, [138] 冯长根, 程津培, 刘德培, 袁驷, 彭先觉, 钟南山, 许智宏, 姒健敏, 饶子和, 龚克, 杨卫. 建立博士毕业生临时研究岗位制度,缓解承担国家重大科研项目人才紧缺问题. 科技导报[J]. 2012, 30(7): 15-17, http://lib.cqvip.com/Qikan/Article/Detail?id=41337404.
[139] Xu, Jiwei, Peng, Wei, Sun, Yao, Wang, Xiangxi, Xu, Yihui, Li, Xuemei, Gao, Guangxia, Rao, Zihe. Structural study of MCPIP1 N-terminal conserved domain reveals a PIN-like RNase. NUCLEIC ACIDS RESEARCH[J]. 2012, 40(14): 6957-6965, http://www.irgrid.ac.cn/handle/1471x/756945.
[140] Guo, Yu, Wang, Wenming, Ji, Wei, Deng, Maping, Sun, Yuna, Zhou, Honggang, Yang, Cheng, Deng, Fei, Wang, Hualin, Hu, Zhihong, Lou, Zhiyong, Rao, Zihe. Crimean-Congo hemorrhagic fever virus nucleoprotein reveals endonuclease activity in bunyaviruses. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 109(13): 5046-5051, http://www.irgrid.ac.cn/handle/1471x/756745.
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[142] Wang, Xiangxi, Peng, Wei, Ren, Jingshan, Hu, Zhongyu, Xu, Jiwei, Lou, Zhiyong, Li, Xumei, Yin, Weidong, Shen, Xinliang, Porta, Claudine, Walter, Thomas S, Evans, Gwyndaf, Axford, Danny, Owens, Robin, Rowlands, David J, Wang, Junzhi, Stuart, David I, Fry, Elizabeth E, Rao, Zihe. A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2012, 19(4): 424-429, http://www.irgrid.ac.cn/handle/1471x/756710.
[143] Zhang, Wenzheng, Fu, Sheng, Liu, Xuefeng, Zhao, Xuelian, Zhang, Wenchi, Peng, Wei, Wu, Congying, Li, Yuanyuan, Li, Xuemei, Bartlam, Mark, Zeng, ZongHao, Zhan, Qimin, Rao, Zihe. Crystal structure of human Gadd45 gamma reveals an active dimer (vol 2, pg 814, 2011). PROTEIN & CELLnull. 2012, 3(3): 239-239, http://www.irgrid.ac.cn/handle/1471x/756990.
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科研活动

   
科研项目
( 1 ) 小RNA病毒感染与致病机制的结构基础, 主持, 国家级, 2014-01--2018-12
( 2 ) 生物治疗协同创新中心, 主持, 研究所(学校), 2014-01--2018-12
( 3 ) 生物超大分子复合体的结构、功能与调控, 主持, 部委级, 2014-01--2018-12
参与会议
(1)Structural genomics of Picornavirus   国际化学生物学大会   2015-08-28
(2)Molecular Mechanism of entry of hand-foot and mouth disease (HFMD) virus   第一届世界医学峰会   2015-07-07
(3)Structural insights into the agents of hand, foot and mouth disease   亚洲生物物理大会   2015-05-08
(4)Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71   2015免疫学国际研讨会   2015-04-24
(5)Structural insights into the agents of hand, foot and mouth disease   2015-04-09
(6)Molecular Mechanism of entry of hand-foot and mouth disease (HFMD) virus   2015亚太地区肿瘤生物学和医学学术会议大会   2015-03-20
(7)我国结构生物学发展现状对同步辐射蛋白质线站建设的思考   上海光源用户年会   饶子和   2009-11-29

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