肿瘤基因组学、药物遗传学

   

071022-基因组学
071010-生物化学与分子生物学
071007-遗传学

癌症基因表达调控，非编码RNA
癌症基因组学
药物遗传学，表观遗传学

1999-09--2005-07   北京大学   博士

-- 研究生

-- 博士

​2005年7月-2009年7月在美国芝加哥大学医学院 血液肿瘤学和药物遗传与基因组学进行博士后研究，

2008年8月-至今在中国科学院北京基因组研究所任研究员。

2009-08~现在, 中国科学院北京基因组研究所, 研究员
2005-08~2009-08,美国芝加哥大学, 博士后、研究助理

遗传咨询入门
分子生物学与基因组学
基因组学前沿
基因组学

   

（ 1 ） 天花粉蛋白突变体及其编码基因, 发明, 2014, 第 1 作者, 专利号: 200410074324.6
（ 2 ） Mutants of Trichosanthin With Anti-Tumor Activity and Lowered Side-Effects., 发明, 2006, 第 1 作者, 专利号: US2008261874/WO2006026906

   

[1] Lan Yu, Xiaolu Hu, Rongrong Xu, Yimeng Zhao, Lijuan Xiong, Jiaxuan Ai, Xing Wang, Xiaoqing Chen, Yinying Ba, Zhikai Xing, Chongye Guo, Shuangli Mi, Xia Wu. Piperine promotes PI3K/AKT/mTOR-mediated gut-brain autophagy to degrade α-Synuclein in Parkinson’s disease rats. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2024, 第 12 作者  通讯作者  322(null): http://dx.doi.org/10.1016/j.jep.2023.117628.
[2] Journal of ethnopharmacology. 2024,   通讯作者  
[3] Huaiyu Tong, Chongye Guo, Liang Liang, Hua Mi, Meng Li, Yiheng Yin, Lijun Shang, Shuangli Mi, Xinguang Yu. Implication of a de novo Variant in ciliary rootlet coiled- coil (CROCC) with assimilation of atlas (AOA). Genetics & Applications[J]. 2022, 第 8 作者  通讯作者  6(1): 11-26, https://genapp.ba/editions/index.php/journal/article/view/73.
[4] Xing, Zhikai, Li, Hui, Li, Meng, Gao, Ran, Guo, Chongye, Mi, Shuangli. Disequilibrium in chicken gut microflora with avian colibacillosis is related to microenvironment damaged by antibiotics. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2021, 第 6 作者  通讯作者  762: http://dx.doi.org/10.1016/j.scitotenv.2020.143058.
[5] Li, Yangyang, Zhang, Jian, Li, Sha, Guo, Chongye, Li, Qian, Zhang, Xin, Li, Meng, Mi, Shuangli. Heterogeneous Nuclear Ribonucleoprotein A1 Loads Batched Tumor-Promoting MicroRNAs Into Small Extracellular Vesicles With the Assist of Caveolin-1 in A549 Cells. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2021, 第 8 作者  通讯作者  9: http://dx.doi.org/10.3389/fcell.2021.687912.
[6] Liang, Liang, Gu, Wenbin, Li, Meng, Gao, Ran, Zhang, Xin, Guo, Chongye, Mi, Shuangli. The long noncoding RNA HOTAIRM1 controlled by AML1 enhances glucocorticoid resistance by activating RHOA/ROCK1 pathway through suppressing ARHGAP18. CELL DEATH & DISEASE[J]. 2021, 第 7 作者  通讯作者  12(7): http://dx.doi.org/10.1038/s41419-021-03982-4.
[7] Lan, Yongqing, Li, Meng, Mi, Shuangli. Identification of Potential Key lncRNAs in the Context of Mouse Myeloid Differentiation by Systematic Transcriptomics Analysis. GENES[J]. 2021, 第 3 作者  通讯作者  12(5): https://doaj.org/article/29204321a53245c3aabfbf2f037973a2.
[8] Shenli Wang, Chongye Guo, Zhikai Xing, Meng Li, Haiying Yang, Yunting Zhang, Fazheng Ren, Lishui Chen, Shuangli Mi. Dietary Intervention With α-Amylase Inhibitor in White Kidney Beans Added Yogurt Modulated Gut Microbiota to Adjust Blood Glucose in Mice. FRONTIERS IN NUTRITION[J]. 2021, 第 9 作者  通讯作者  8: https://doaj.org/article/519ac278595348c39e58efa1f5b562b0.
[9] Zhang, Jian, Fu, Bin, Li, Meng, Mi, Shuangli. Secretome of Activated Fibroblasts Induced by Exosomes for the Discovery of Biomarkers in Non-Small Cell Lung Cancer. SMALL[J]. 2021, 第 4 作者  通讯作者  17(4): http://dx.doi.org/10.1002/smll.202004750.
[10] Lu, SiYao, Fu, ChongLei, Liang, Liang, Yang, Bo, Shen, Wei, Wang, QiuWen, Chen, Yun, Chen, YanFen, Liu, YaoNan, Zhu, Lin, Zhao, Jieqing, Shi, Wei, Mi, Shuangli, Yao, Jun. miR-218-2 regulates cognitive functions in the hippocampus through complement component 3-dependent modulation of synaptic vesicle release. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2021, 第 13 作者118(14): http://dx.doi.org/10.1073/pnas.2021770118.
[11] Han, Zhijun, Li, Yangyang, Zhang, Jian, Guo, Chongye, Li, Qian, Zhang, Xin, Lan, Yongqing, Gu, Wenbin, Xing, Zhikai, Liang, Liang, Li, Meng, Mi, Shuangli. Tumor-derived circulating exosomal miR-342-5p and miR-574-5p as promising diagnostic biomarkers for early-stage Lung Adenocarcinoma. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES[J]. 2020, 第 12 作者  通讯作者  17(10): 1428-1438, http://dx.doi.org/10.7150/ijms.43500.
[12] Miao, Xuexia, Li, Yueying, Zheng, Caihong, Wang, Lifei, Jin, Chen, Chen, Lei, Mi, Shuangli, Zhai, Weiwei, Wang, QianFei, Cai, Jun. A promising iPS-based single-cell cloning strategy revealing signatures of somatic mutations in heterogeneous normal cells. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL[J]. 2020, 第 7 作者18: 2326-2335, http://dx.doi.org/10.1016/j.csbj.2020.08.026.
[13] Shen, Wei, Wang, QiuWen, Liu, YaoNan, Marchetto, Maria C, Linker, Sara, Lu, SiYao, Chen, Yun, Liu, Chuihong, Guo, Chongye, Xing, Zhikai, Shi, Wei, Kelsoe, John R, Alda, Martin, Wang, Hongwei, Zhong, Yi, Sui, SenFang, Zhao, Mei, Yang, Yiming, Mi, Shuangli, Cao, Liping, Gage, Fred H, Yao, Jun. Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 第 19 作者117(8): 4392-4399, https://www.webofscience.com/wos/woscc/full-record/WOS:000516771500066.
[14] Xing, Zhikai, Zhang, Yunting, Li, Meng, Guo, Chongye, Mi, Shuangli. RBUD: A New Functional Potential Analysis Approach for Whole Microbial Genome Shotgun Sequencing. MICROORGANISMS[J]. 2020, 第 5 作者  通讯作者  8(10): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650719/.
[15] 郭翀晔, 邢志凯, 李蒙, 胡晓璐, 吴霞, 陈历水, 米双利. 植物益生元对肠道菌群的调节及对机体糖代谢吸收的影响. 农产品加工[J]. 2019, 第 7 作者  通讯作者  null(6): 52-57, http://lib.cqvip.com/Qikan/Article/Detail?id=7101418182.
[16] 于岚, 邢志凯, 米双利, 吴霞. 中药对肠道菌群的调节作用. 中国中药杂志[J]. 2019, 第 3 作者  通讯作者  null(1): 34-39, http://lib.cqvip.com/Qikan/Article/Detail?id=90719089504849574849484853.
[17] Zheng, Yi, Shen, Wei, Zhang, Jian, Yang, Bo, Liu, YaoNan, Qi, Huihui, Yu, Xia, Lu, SiYao, Chen, Yun, Xu, YuZhou, Li, Yun, Gage, Fred H, Mi, Shuangli, Yao, Jun. CRISPR interference-based specific and efficient gene inactivation in the brain (vol 21, pg 447, 2018). NATURE NEUROSCIENCE[J]. 2018, 第 13 作者  通讯作者  21(6): 894-894, https://www.webofscience.com/wos/woscc/full-record/WOS:000433232600018.
[18] Zheng, Yi, Shen, Wei, Zhang, Jian, Yang, Bo, Liu, YaoNan, Qi, Huihui, Yu, Xia, Lul, SiYao, Chen, Yun, Xu, YuZhou, Lp, Yun, Gage, Fred H, Mi, Shuangli, Yao, Jun. CRISPR interference-based specific and efficient gene inactivation in the brain. NATURENEUROSCIENCE[J]. 2018, 第 13 作者  通讯作者  21(3): 447-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000427776400020.
[19] Mi Shuangli. Early different downstream target of glucocorticoid receptor contributing to Glucocorticoids sensitivity in Kasumi-1 cells. (ASH meeting). Blood. 2016, 第 1 作者  通讯作者  
[20] Mi, Shuangli, Klungland, Arne, Yang, YunGui. Base-excision repair and beyond -A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015. 中国科学:生命科学(英文版)[J]. 2016, 第 1 作者59(1): 89-92, https://www.webofscience.com/wos/woscc/full-record/WOS:000371281300013.
[21] Zhang, Jian, Li, Sha, Li, Lu, Li, Meng, Guo, Chongye, Yao, Jun, Mi, Shuangli. Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2015, 第 7 作者  通讯作者  13(1): 17-24, http://lib.cqvip.com/Qikan/Article/Detail?id=664451415.
[22] Shuangli Mi, Jian Zhang, Wei Zhang, R Stephanie Huang. Circulating MicroRNAs as Biomarkers for Inflammatory Diseases. MICRORNA. 2013, 第 1 作者2(1): 64-72, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092001/.
[23] 王琳, 米双利, 陈杰, 刘芳, 李迎春, 郭彩虹, 张勇, 范钦颖. 孕期暴露因素与新生儿血管瘤发生的关联性研究. 中国药物警戒[J]. 2012, 第 2 作者9(3): 140-143, http://lib.cqvip.com/Qikan/Article/Detail?id=41046578.
[24] Wen, Yujia, Gamazon, Eric R, Bleibel, Wasim K, Wing, Claudia, Mi, Shuangli, McIlwee, Bridget E, Delaney, Shannon M, Duan, Shiwei, Im, Hae Kyung, Dolan, M Eileen. An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers. HUMAN MOLECULAR GENETICS[J]. 2012, 第 5 作者21(7): 1470-1480, https://www.webofscience.com/wos/woscc/full-record/WOS:000301299700002.
[25] 米双利. 新生儿血管瘤发生的高危因素. 中华围产医学杂志. 2012, 第 1 作者
[26] Wang, Qianfei, Wu, George, Mi, Shuangli, He, Fuhong, Wu, Jun, Dong, Jingfang, Luo, Roger T, Mattison, Ryan, Kaberlein, Joseph J, Prabhakar, Shyam, Ji, Hongkai, Thirman, Michael J. MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome. BLOOD[J]. 2011, 第 3 作者117(25): 6895-6905, https://www.webofscience.com/wos/woscc/full-record/WOS:000291979800021.
[27] Mi, Shuangli, Li, Zejuan, Chen, Ping, He, Chunjiang, Cao, Donglin, Elkahloun, Abdel, Lu, Jun, Pelloso, Luis A, Wunderlich, Mark, Huang, Hao, Luo, Roger T, Sun, Miao, He, Miao, Neilly, Mary Beth, ZeleznikLe, Nancy J, Thirman, Michael J, Mulloy, James C, Liu, Paul P, Rowley, Janet D, Chen, Jianjun. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2010, 第 1 作者107(8): 3710-3715, https://www.webofscience.com/wos/woscc/full-record/WOS:000275130900078.
[28] Duan, Shiwei, Mi, Shuangli, Zhang, Wei, Dolan, M Eileen. Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes. RNA BIOLOGY[J]. 2009, 第 2 作者6(4): 412-425, https://www.webofscience.com/wos/woscc/full-record/WOS:000275572500012.
[29] Li, Zejuan, Luo, Roger T, Mi, Shuangli, Sun, Miao, Chen, Ping, Bao, Jingyue, Neilly, Mary Beth, Jayathilaka, Nimanthi, Johnson, Deborah S, Wang, Lili, Lavau, Catherine, Zhang, Yanming, Tseng, Charles, Zhang, Xiuqing, Wang, Jian, Yu, Jun, Yang, Huanming, Wang, San Ming, Rowley, Janet D, Chen, Jianjun, Thirman, Michael J. Consistent Deregulation of Gene Expression between Human and Murine MLL Rearrangement Leukemias. CANCER RESEARCH[J]. 2009, 第 3 作者69(3): 1109-1116, https://www.webofscience.com/wos/woscc/full-record/WOS:000263048700048.
[30] Hartford, Christine M, Duan, Shiwei, Delaney, Shannon M, Mi, Shuangli, Kistner, Emily O, Lamba, Jatinder K, Huang, R Stephanie, Dolan, M Eileen. Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity. BLOOD[J]. 2009, 第 4 作者113(10): 2145-2153, http://dx.doi.org/10.1182/blood-2008-05-154302.
[31] Mi Shuangli. Candidate genes pharmacogenetics of anti-cancer agents.. Pharmacogenomics. 2009, 第 1 作者
[32] Duan, Shiwei, Huang, R Stephanie, Zhang, Wei, Mi, Shuangli, Bleibel, Wasim K, Kistner, Emily O, Cox, Nancy J, Dolan, M Eileen. Expression and alternative splicing of folate pathway genes in HapMap lymphoblastoid cell lines. PHARMACOGENOMICS[J]. 2009, 第 4 作者10(4): 549-563, https://www.webofscience.com/wos/woscc/full-record/WOS:000265727300009.
[33] Li, Zejuan, Lu, Jun, Sun, Miao, Mi, Shuangli, Zhang, Hao, Luo, Roger T, Chen, Ping, Wang, Yungui, Yan, Ming, Qian, Zhijian, Neilly, Mary Beth, Jin, Jie, Zhang, Yanming, Bohlander, Stefan K, Zhang, DongEr, Larson, Richard A, Le Beau, Michelle M, Thirman, Michael J, Golub, Todd R, Rowley, Janet D, Chen, Jianjun. Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2008, 第 4 作者105(40): 15535-15540, https://www.webofscience.com/wos/woscc/full-record/WOS:000260360500058.
[34] Mi Shuangli. Recent patents on the identification and clinical application of microRNAs and target genes.. Recent Patents on DNA and Gene Sequences. 2007, 第 1 作者
[35] Shuangli Mi PhD, Jun Lu PhD, Miao Sun MS, Zejuan Li PhD, Hao Zhang MS, Mary Beth Neilly MS, Yungui Wang PhD, Zhijian Qian PhD, Jie Jin MD, Yanming Zhang MD, Stefan K Bohlander MD, Michelle M Le BA PhD, Richard Larson MD, Todd R Golub MD, Janet D Rowley MD, Jianjun Chen PhD. MicroRNA Expression Signatures Accurately Discriminate Acute Lymphoblastic Leukemia from Acute Myeloid Leukemia.. BLOOD. 2007, 110(11): 231-231, 
[36] Mi, SL, An, CC, Wang, Y, Chen, JY, Che, NY, Gao, Y, Chen, ZL. Trichomislin, a novel ribosome-inactivating protein, induces apoptosis that involves mitochondria and caspase-3. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS[J]. 2005, 434(2): 258-265, 
[37] Wang, Y, Mi, SL, Lou, MY, Gao, Y, Chen, ZL, An, CC. Enhanced Green Fluorescence Protein tracks trichosanthin in human choriocarcinoma cells as a feasible and stable reporter. FRONTIERS IN BIOSCIENCE-LANDMARK[J]. 2005, 10: 2279-2284, 
[38] Stark AL, Zhang W, Mi S, Duan S, O’Donnell PH, Huang RS, Dolan ME. Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines. THE PHARMACOGENOMICS JOURNAL. 10(6): 505-512, https://www.webofscience.com/wos/woscc/full-record/WOS:000284835600004.

   

（ 1 ） 白血病异常融合蛋白MLL-ENL对小鼠细胞全基因组microRNA的表达调控研究, 主持, 国家级, 2011-01--2013-12
（ 2 ） 表观遗传变异在肺癌发生发展中的作用和机制, 参与, 国家级, 2011-01--2015-12
（ 3 ） 利用开放科学数据云促进高通量肿瘤基因组研究, 主持, 国家级, 2012-01--2016-12
（ 4 ） 中国人群精准医学研究计划, 参与, 部委级, 2015-09--2018-12
（ 5 ） RNA表观遗传对DNA损伤修复调控机制, 参与, 国家级, 2015-01--2019-12

（1）Whole Genome Binding Location Analysis of MLL-ENL and the Impact to the Deregulation of microRNAs.   Shuangli Mi, Fuhong He, Jun Wu, Jing Zhou, George Wu, Michael J Thirman, Hongkai Ji, Qian-fei Wang   2010-12-03

   

清华大学，中国检验检疫科学研究院，首都师范大学，芝加哥大学

已指导学生

顾文彬  02  63228  

李莎  02  67917  

现指导学生

张健  01  19183  

兰永青  01  67917  

邢志凯  01  67917  

高然  02  67917  

顾文彬  01  67917  

梁良  01  19183  

李倩  02  67917  

李阳阳  01  67917