流感等病毒的感染机制及病毒与宿主相互作用的机制；病毒感染与炎症治疗；新型抗感染药物及疫苗的研发。

   

1991.05-1996.05，美国佛罗里达大学，博士

1982.08-1985.08，北京农业大学，硕士

1978.03-1982.08，北京农业大学，学士

1988.08-1989.08美国国立动物病研究中心，访问学者

1996.05-1998.03美国Oklahoma大学医学中心，博士后 

1998.03-2000.12美国哈佛休斯医学研究所，Research Associate

2000.01-2004.08美国GENZYME 公司，高级科学家

2004.10-至今 中国科学院微生物研究所，二级研究员，中国科学院大学博士生导师。中国科学院病原微生物与免疫学重点实验室副主任、生物安全三级实验室主任（2011-2021年）、分子病毒中心主任。

医学病毒学
生物安全概论
抗感染分子病毒学
抗感免疫学
分子病毒学

   

（1） 获中国科学院大学“李佩优秀教师奖”, 其他, 2021
（2） 《医学病毒学》课程获中国科学院大学校级“研究生优秀课程”, 其他, 2020
（3） 获享受国务院政府特殊津贴专家, 国家级, 2020
（4） 辽宁省畜牧兽医科技贡献奖, 一等奖, 市地级, 2016
（5） 山东省科学技术奖, 一等奖, 省级, 2015
（6） 中国科学院教学成果奖, 二等奖, 院级, 2008
（7） Thomson Scientific论文卓越奖，THOMSOM RERTERS, 三等奖, 其他, 2007
（8） 中国科学院“****”获得者, , 院级, 2004

   

[1] Jiao, Pengtao, Fan, Wenhui, Ma, Xiaoya, Lin, Runshan, Zhao, Yuna, Li, Yabo, Zhang, He, Jia, Xiaojuan, Bi, Yuhai, Feng, Xiaoli, Li, Minghua, Liu, Wenjun, Zhang, Ke, Sun, Lei. SARS-CoV-2 nonstructural protein 6 triggers endoplasmic reticulum stress-induced autophagy to degrade STING1. AUTOPHAGY[J]. 2023, 19(12): 3113-3131, http://dx.doi.org/10.1080/15548627.2023.2238579.
[2] Jiao, Pengtao, Wang, Shuchao, Fan, Wenhui, Zhang, He, Yin, Hongyan, Shang, Yingli, Zhu, Hongfei, Liu, Wenjun, Hu, Rongliang, Sun, Lei. Recombinant porcine interferon cocktail delays the onset and lessens the severity of African swine fever. ANTIVIRAL RESEARCH[J]. 2023, 215: http://dx.doi.org/10.1016/j.antiviral.2023.105644.
[3] Heqiao Li, Wenxian Yang, Huizi Li, Xiaoyuan Bai, He Zhang, Wenhui Fan, Wenjun Liu, Lei Sun. PROTAC targeting cyclophilin A controls virus-induced cytokine storm. ISCIENCE[J]. 2023, 26(9): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448112/.
[4] Jie Min, Yucen Li, Xinda Li, Mingge Wang, Huizi Li, Yuhai Bi, Ping Xu, Wenjun Liu, Xin Ye, Jing Li. The circRNA circVAMP3 restricts influenza A virus replication by interfering with NP and NS1 proteins. PLOS PATHOGENS[J]. 2023, 19(8): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441791/.
[5] Fan, Wenhui, Sun, Shanshan, Zhang, Ning, Zhang, Yuan, Jiao, Pengtao, Wang, Jian, Gao, George F, Liu, Wenjun, Bi, Yuhai, Yang, Limin. Nasal delivery of thermostable and broadly neutralizing antibodies protects mice against SARS-CoV-2 infection. SIGNAL TRANSDUCTION AND TARGETED THERAPYnull. 2022, 7(1): 628-631, http://dx.doi.org/10.1038/s41392-022-00911-5.
[6] Lihong He, Wenqiang Sun, Limin Yang, Wenjun Liu, Jing Li. A multiple-target mRNA-LNP vaccine induces protective immunity against experimental multi-serotype DENV in mice. VIROLOGICA SINICA[J]. 2022, 37(5): 746-757, http://dx.doi.org/10.1016/j.virs.2022.07.003.
[7] Bai, Xiaoyuan, Yang, Wenxian, Li, Heqiao, Zhao, Yuna, Fan, Wenhui, Zhang, He, Liu, Wenjun, Sun, Lei. Cyclosporine A Regulates Influenza A Virus-induced Macrophages Polarization and Inflammatory Responses by Targeting Cyclophilin A. FRONTIERS IN IMMUNOLOGY[J]. 2022, 13: http://dx.doi.org/10.3389/fimmu.2022.861292.
[8] Wenxian Yang, Xiaoyuan Bai, Heqiao Li, Huizi Li, Wenhui Fan, He Zhang, Wenjun Liu, Lei Sun. Influenza A and B Virus-Triggered Epithelial–Mesenchymal Transition Is Relevant to the Binding Ability of NA to Latent TGF-β. FRONTIERS IN MICROBIOLOGY[J]. 2022, 13: https://doaj.org/article/d69e281ce87047f0a0de890393e7c8fb.
[9] Jie Min, Ying Cao, Haizhou Liu, Di Liu, Wenjun Liu, Jing Li. RNA Sequencing Demonstrates That Circular RNA Regulates Avian Influenza Virus Replication in Human Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2022, 23(17): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9456167/.
[10] Sun, Wenqiang, He, Lihong, Lou, Huicong, Fan, Wenhui, Yang, Limin, Cheng, Gong, Liu, Wenjun, Sun, Lei. The Cross-Protective Immunity Landscape Among Different SARS-CoV-2 Variant RBDs. FRONTIERS IN IMMUNOLOGY[J]. 2022, 13: http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000815671000001.
[11] Wenxian Yang, Xiaoyuan Bai, Xiaohan Luan, Jie Min, Xiaodong Tian, Heqiao Li, Huizi Li, Wenqiang Sun, Wei Liu, Wenhui Fan, Wenjun Liu, Lei Sun. Delicate regulation of IL-1β-mediated inflammation by cyclophilin A. CELL REPORTS. 2022, 38(11): http://dx.doi.org/10.1016/j.celrep.2022.110513.
[12] Sun, Wenqiang, He, Lihong, Zhang, He, Tian, Xiaodong, Bai, Zhihua, Sun, Lei, Yang, Limin, Jia, Xiaojuan, Bi, Yuhai, Luo, Tingrong, Cheng, Gong, Fan, Wenhui, Liu, Wenjun, Li, Jing. The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2021, 6(1): 3074-3084, http://dx.doi.org/10.1038/s41392-021-00750-w.
[13] Tian, Xiaodong, Liu, Ling, Jiang, Wenguo, Zhang, He, Liu, Wenjun, Li, Jing. Potent and Persistent Antibody Response in COVID-19 Recovered Patients. FRONTIERS IN IMMUNOLOGY[J]. 2021, 12: https://doaj.org/article/c3fb02d33c0d4578958d10e4cb29865c.
[14] Bai, Xiaoyuan, Yang, Wenxian, Luan, Xiaohan, Li, Huizi, Li, Heqiao, Tian, Deyu, Fan, Wenhui, Li, Jing, Wang, Beinan, Liu, Wenjun, Sun, Lei. Induction of cyclophilin A by influenza A virus infection facilitates group A Streptococcus coinfection. CELL REPORTS[J]. 2021, 35(7): http://dx.doi.org/10.1016/j.celrep.2021.109159.
[15] Limin Yang, Deyu Tian, Jianbao Han, Wenhui Fan, Yuan Zhang, Yunlong Li, Wenqiang Sun, Yanqiu Wei, Xiaodong Tian, Dandan Yu, Xiaoli Feng, Gong Cheng, Yuhai Bi, Yongtang Zheng, Wenjun Liu. A recombinant receptor-binding domain in trimeric form generates protective immunity against SARSCoV-2 infection in nonhuman primates. THE INNOVATION[J]. 2021, 2(3): 94-102, http://lib.cqvip.com/Qikan/Article/Detail?id=7105571736.
[16] Li, Jing, Liu, Wenjun. Puzzle of highly pathogenic human coronaviruses (2019-nCoV). PROTEIN & CELL[J]. 2020, 11(4): 235-238, http://lib.cqvip.com/Qikan/Article/Detail?id=7101637423.
[17] Pengtao Jiao, Wenhui Fan, Ying Cao, He Zhang, Lu Tian, Lei Sun, Tingrong Luo, Wenjun Liu, Jing Li. Robust induction of interferon and interferon-stimulated gene expression by influenza B/Yamagata lineage virus infection of A549 cells. PLOS ONE[J]. 2020, 15(4): https://doaj.org/article/4043dadf44554aecade6d1a559e2db75.
[18] Zheng, Weinan, Fan, Wenhui, Zhang, Shuang, Jiao, Pengtao, Shang, Yingli, Cui, Liang, Mahesutihan, Madina, Li, Jing, Wang, Dayan, Gao, George Fu, Sun, Lei, Liu, Wenjun. Naproxen Exhibits Broad Anti-influenza Virus Activity in Mice by Impeding Viral Nucleoprotein Nuclear Export. CELL REPORTS[J]. 2019, 27(6): 1875-+, http://dx.doi.org/10.1016/j.celrep.2019.04.053.
[19] Li, Jing, Zhang, Kun, Fan, Wenhui, Zhang, Shuang, Li, Yun, Gu, Jinyan, Zhou, Jiyong, Liu, Wenjun. Transcriptome Profiling Reveals Differential Effect of Interleukin-17A Upon Influenza Virus Infection in Human Cells. FRONTIERS IN MICROBIOLOGY[J]. 2019, 10: https://doaj.org/article/4f8ab37b0c0d407eb189534cac5ca398.
[20] Liu, Lirong, Fan, Wenhui, Zhang, He, Zhang, Shuang, Cui, Liang, Wang, Meng, Bai, Xiaoyuan, Yang, Wenxian, Sun, Lei, Yang, Limin, Liu, Wenjun, Li, Jing. Interferon as a Mucosal Adjuvant for an Influenza Vaccine in Pigs. VIROLOGICA SINICA[J]. 2019, 34(3): 324-333, [21] Cui, Liang, Mahesutihan, Madina, Zheng, Weinan, Meng, Lijun, Fan, Wenhui, Li, Jing, Ye, Xin, Liu, Wenjun, Sun, Lei. CDC25B promotes influenza A virus replication by regulating the phosphorylation of nucleoprotein. VIROLOGY[J]. 2018, 525: 40-47, http://dx.doi.org/10.1016/j.virol.2018.09.005.
[22] 李文博, 刘薇, 陈璨, 范文辉, 张鹤, 刘文军, 孙蕾. 胞外亲环素A对炎症发生的影响及其抗体在抑制炎症反应中的作用. 生物工程学报[J]. 2018, 34(1): 90-101, http://lib.cqvip.com/Qikan/Article/Detail?id=674348273.
[23] Sun, Yeping, Jiang, Jingwen, Tien, Po, Liu, Wenjun, Li, Jing. IFN-: A new spotlight in innate immunity against influenza virus infection. PROTEIN & CELL[J]. 2018, 9(10): 832-837, https://doaj.org/article/a011b908e6024c628aa686c739675315.
[24] Chen, Can, Fan, Wenhui, Li, Jing, Zheng, Weinan, Zhang, Shuang, Yang, Limin, Liu, Di, Liu, Wenjun, Sun, Lei. A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY[J]. 2018, 8: http://202.127.146.157/handle/2RYDP1HH/5226.
[25] Mahesutihan, Madina, Zheng, Weinan, Cui, Liang, Li, Yun, Jiao, Pengtao, Yang, Wenxian, Liu, Wei, Li, Jing, Fan, Wenhui, Yang, Limin, Liu, Wenjun, Sun, Lei. CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus. VIROLOGICA SINICA[J]. 2018, 33(5): 440-448, http://lib.cqvip.com/Qikan/Article/Detail?id=6100074074.
[26] Li, Jing, Zheng, Weinan, Hou, Lidan, Chen, Can, Fan, Wenhui, Qu, Hongren, Jiang, Jingwen, Liu, Jinhua, Gao, George F, Zhou, Jiyong, Sun, Lei, Liu, Wenjun. Differential nucleocytoplasmic shuttling of the nucleoprotein of influenza a viruses and association with host tropism. CELLULAR MICROBIOLOGY[J]. 2017, 19(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000398678000004.
[27] Liu, Wei, Li, Jing, Zheng, Weinan, Shang, Yingli, Zhao, Zhendong, Wang, Shanshan, Bi, Yuhai, Zhang, Shuang, Xu, Chongfeng, Duan, Ziyuan, Zhang, Lianfeng, Wang, Yue L, Jiang, Zhengfan, Liu, Wenjun, Sun, Lei. Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses. ELIFE[J]. 2017, 6: https://doaj.org/article/6555b1c46ad8457eb97313f044b02231.
[28] Zheng, Weinan, Cao, Shuaishuai, Chen, Can, Li, Jing, Zhang, Shuang, Jiang, Jingwen, Niu, Yange, Fan, Wenhui, Li, Yun, Bi, Yuhai, Gao, George F, Sun, Lei, Liu, Wenjun. Threonine 80 phosphorylation of non-structural protein 1 regulates the replication of influenza A virus by reducing the binding affinity with RIG-I. CELLULAR MICROBIOLOGY[J]. 2017, 19(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000393306000001.
[29] Li, Jing, Chen, Can, Wong, Gary, Dong, Wei, Zheng, Weinan, Li, Yun, Sun, Lei, Zhang, Lianfeng, Gao, George F, Bi, Yuhai, Liu, Wenjun. Cyclophilin A protects mice against infection by influenza A virus. SCIENTIFIC REPORTS[J]. 2016, 6: [30] Jiang, Jingwen, Li, Jing, Fan, Wenhui, Zheng, Weinan, Yu, Meng, Chen, Can, Sun, Lei, Bi, Yuhai, Ding, Chan, Gao, George F, Liu, Wenjun. Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection. JOURNAL OF VIROLOGY[J]. 2016, 90(14): 6263-6275, https://www.webofscience.com/wos/woscc/full-record/WOS:000378658800009.
[31] Zheng, Weinan, Li, Jing, Wang, Shanshan, Cao, Shuaishuai, Jiang, Jingwen, Chen, Can, Ding, Chan, Qin, Chuan, Ye, Xin, Gao, George F, Liu, Wenjun. Phosphorylation Controls the Nuclear-Cytoplasmic Shuttling of Influenza A Virus Nucleoprotein. JOURNAL OF VIROLOGY[J]. 2015, 89(11): 5822-5834, http://www.corc.org.cn/handle/1471x/2159710.
[32] Bi, Yuhai, Xie, Qing, Zhang, Shuang, Li, Yun, Xiao, Haixia, Jin, Tao, Zheng, Weinan, Li, Jing, Jia, Xiaojuan, Sun, Lei, Liu, Jinhua, Qin, Chuan, Gao, George F, Liu, Wenjun. Assessment of the Internal Genes of Influenza A (H7N9) Virus Contributing to High Pathogenicity in Mice. JOURNAL OF VIROLOGY[J]. 2015, 89(1): 2-13, [33] Cao, Shuai, Jiang, Jingwen, Li, Jing, Li, Yan, Yang, Limin, Wang, Shanshan, Yan, Jinghua, Gao, George F, Liu, Wenjun. Characterization of the Nucleocytoplasmic Shuttle of the Matrix Protein of Influenza B Virus. JOURNAL OF VIROLOGY[J]. 2014, 88(13): 7464-7473, https://www.webofscience.com/wos/woscc/full-record/WOS:000337240700031.
[34] Gao, Shengyan, Wang, Shanshan, Cao, Shuai, Sun, Lei, Li, Jing, Bi, Yuhai, Gao, George F, Liu, Wenjun. Characteristics of Nucleocytoplasmic Transport of H1N1 Influenza A Virus Nuclear Export Protein. JOURNAL OF VIROLOGY[J]. 2014, 88(13): 7455-7463, https://www.webofscience.com/wos/woscc/full-record/WOS:000337240700030.
[35] Chen, Caiwei, Li, Jing, Bi, Yuhai, Yang, Limin, Meng, Shanshan, Zhou, Yuancheng, Jia, Xiaojuan, Meng, Songdong, Sun, Lei, Liu, Wenjun. Synthetic B- and T-cell epitope peptides of porcine reproductive and respiratory syndrome virus with Gp96 as adjuvant induced humoral and cell-mediated immunity. VACCINE[J]. 2013, 31(14): 1838-1847, http://dx.doi.org/10.1016/j.vaccine.2013.01.049.
[36] Xiaoling Liu, Zhendong Zhao, Wenjun Liu. Insights into the Roles of Cyclophilin A During Influenza Virus Infection. VIRUSES[J]. 2013, 5(1): 182-191, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564116/.
[37] Hongren Qu, Limin Yang, Shanshan Meng, Lei Xu, Yuhai Bi, Xiaojuan Jia, Jing Li, Lei Sun, Wenjun Liu. The differential antiviral activities of chicken interferon α (ChIFN-α) and ChIFN-β are related to distinct interferon-stimulated gene expression.. PLOS ONE[J]. 2013, 8(3): https://doaj.org/article/e0448942715a47a9b2a35447afb4d593.
[38] Wang, Shanshan, Zhao, Zhendong, Bi, Yuhai, Sun, Lei, Liu, Xiaoling, Liu, Wenjun. Tyrosine 132 Phosphorylation of Influenza A Virus M1 Protein Is Crucial for Virus Replication by Controlling the Nuclear Import of M1. JOURNAL OF VIROLOGY[J]. 2013, 87(11): 6182-6191, https://www.webofscience.com/wos/woscc/full-record/WOS:000318907500012.
[39] Cao, Shuai, Liu, Xiaoling, Yu, Maorong, Li, Jing, Jia, Xiaojuan, Bi, Yuhai, Sun, Lei, Gao, George F, Liu, Wenjun. A Nuclear Export Signal in the Matrix Protein of Influenza A Virus Is Required for Efficient Virus Replication. JOURNAL OF VIROLOGY[J]. 2012, 86(9): 4883-4891, https://www.webofscience.com/wos/woscc/full-record/WOS:000302777800015.
[40] Liu, Xiaoling, Zhao, Zhendong, Li, Zheng, Xu, Chongfeng, Sun, Lei, Chen, Jilong, Liu, Wenjun. Cyclosporin A Inhibits the Influenza Virus Replication through Cyclophilin A-Dependent and -Independent Pathways. PLOS ONE[J]. 2012, 7(5): https://doaj.org/article/bd492e7179a143f08bb0476e97a69f86.
[41] Yu, Maorong, Liu, Xiaoling, Cao, Shuai, Zhao, Zhendong, Zhang, Ke, Xie, Qing, Chen, Caiwei, Gao, Shengyan, Bi, Yuhai, Sun, Lei, Ye, Xin, Gao, George F, Liu, Wenjun. Identification and Characterization of Three Novel Nuclear Export Signals in the Influenza A Virus Nucleoprotein. JOURNAL OF VIROLOGY[J]. 2012, 86(9): 4970-4980, https://www.webofscience.com/wos/woscc/full-record/WOS:000302777800022.
[42] Cao, Shuai, Shi, Yi, Tan, Shuguang, Song, Hao, Gao, George F, Liu, Wenjun. Reply to "Nuclear Export Signal and Immunodominant CD8(+) T Cell Epitope in Influenza A Virus Matrix Protein 1". JOURNAL OF VIROLOGYnull. 2012, 86(18): 10259-10260, https://www.webofscience.com/wos/woscc/full-record/WOS:000308337500088.
[43] Liu, Xiaoling, Zhao, Zhendong, Xu, Chongfeng, Sun, Lei, Chen, Jilong, Zhang, Lianfeng, Liu, Wenjun. Cyclophilin A Restricts Influenza A Virus Replication through Degradation of the M1 Protein. PLOS ONE[J]. 2012, 7(2): https://doaj.org/article/9cb9177f734e4f3d8574d2ff71a96a5b.
[44] Xu, Chongfeng, Meng, Shanshan, Liu, Xiaoling, Sun, Lei, Liu, Wenjun. Chicken cyclophilin A is an inhibitory factor to influenza virus replication. VIROLOGY JOURNAL[J]. 2010, 7(1): http://124.16.144.217/handle/311023/2338.
[45] Liu, Xiaoling, Sun, Lei, Yu, Maorong, Wang, Zengfu, Xu, Chongfeng, Xue, Qinghua, Zhang, Ke, Ye, Xin, Kitamura, Yoshihiro, Liu, Wenjun. Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication. CELLULAR MICROBIOLOGY[J]. 2009, 11(5): 730-741, http://124.16.144.217/handle/311023/1844.

（1） 病毒学原理, Principles of Virology, 化学工业出版社, 2014-02, 第 1 作者
（2） 医学病毒学原理, 化学工业出版社, 2020-12, 第 1 作者

   

（ 1 ） 重要病毒跨种间感染与传播致病的分子机制研究, 负责人, 国家任务, 2010-07--2014-07
（ 2 ） 宿主因子CypA抑制A型流感病毒感染的动物模型建立, 负责人, 国家任务, 2010-07--2012-07
（ 3 ） 禽流感病毒跨种间传播机制与感染致病的分子机理, 负责人, 中国科学院计划, 2010-07--2012-07
（ 4 ） 新发和突发传染病病原快速诊断和高通量检测技术平台建设, 负责人, 国家任务, 2010-07--2012-07
（ 5 ） 重要家养动物疫病免疫调控机制与功能基因发掘, 负责人, 中国科学院计划, 2013-01--2015-12
（ 6 ） CypA调节流感病毒感染引发细胞因子风暴的分子机制研究, 负责人, 国家任务, 2013-01--2016-12
（ 7 ） 突破二：动物源性流感病毒跨种感染人的分子机制, 负责人, 中国科学院计划, 2013-01--2015-12
（ 8 ） NP磷酸化对A型流感病毒复制的调控机理, 负责人, 国家任务, 2016-01--2019-12
（ 9 ） 动物流感病毒与宿主RNA互作机制研究, 负责人, 国家任务, 2016-07--2020-12
（ 10 ） A型流感病毒的核质穿梭及其对病毒复制的影响, 负责人, 国家任务, 2017-01--2021-12
（ 11 ） 烈性病原抗体类生物制剂研制, 负责人, 中国科学院计划, 2016-01--2018-12
（ 12 ） 突发生物危害事件评估, 参与, 国家任务, 2016-07--2018-12
（ 13 ） 病原微生物与宿主互作的分子机制, 负责人, 国家任务, 2017-01--2019-12
（ 14 ） 诱导黏膜免疫的畜禽疫病新型口服疫苗技术研究, 负责人, 国家任务, 2017-07--2020-12
（ 15 ） 重要动物源病毒病的检测技术及标准研究, 参与, 国家任务, 2016-01--2020-12
（ 16 ） EEID:US-UK-China: 新发禽流感病毒的演进与生态传播动力学的前瞻性研究, 负责人, 国家任务, 2021-01--2025-12