基因组信息及其表达调控是生命多样性和复杂性的重要基础，也是疾病治疗和健康干预的重要靶标和手段。我们特别感兴趣结合基因工程、细胞工程和合成生物学等手段建立新的基因工程技术和细胞/动物模型，用于（1）揭示生殖与再生相关性状及其种间进化差异的调控机制；（2）设计和制造功能定制化的细胞；（3）重大疾病的基因治疗。

   

1001J6-再生医学

干细胞，基因工程

2006-09--2013-01   中国科学院大学/中国科学院动物研究所   理学博士
2002-09--2006-06   武汉大学   学士

研究生

博士

   

2017-09~现在, 中国科学院动物研究所干细胞与生殖生物学国家重点实验室, 副主任
2016-01~现在, 中国科学院动物研究所, 研究员
2013-02~2015-12,中国科学院动物研究所, 星辰研究员

2020-01-01-今,发展中国家科学院（TWAS）, 青年会士
2019-10-10-今,中国医药生物技术协会基因编辑技术分会, 常务委员
2019-10-01-今,中国动物学会生殖生物学分会, 副主任委员
2019-05-01-今,中国实验动物学会灵长类实验动物专业委员会, 常务委员
2018-05-01-今,中国细胞生物学学会衰老细胞生物学分会, 委员
2014-01-01-今,中国科学院青年创新促进会, 会员
2013-09-01-今,中国遗传学会青年委员会, 委员

干细胞生物学
现代生殖医学之生理基础
胚胎工程
干细胞前沿技术
生殖生理学
干细胞研究进展系列讲座

   

（1） 中国细胞生物学学会干细胞生物学分会干细胞研究创新奖, 其他, 2020
（2） 中国科学院杰出科技成就奖, , 院级, 2020
（3） 中国科学院青年科学家奖, , 院级, 2018
（4） 第十二届中国科学院杰出青年, , 院级, 2017
（5） 中源协和生命医学创新突破奖, , 其他, 2016
（6） 卢嘉锡青年人才奖, 院级, 2015
（7） 中国科学院杰出科技成就奖, , 院级, 2013
（8） 日本实验动物学会国际奖, , 其他, 2013

   

[1] Yangcan Chen, Shengqiu Luo, Yanping Hu, Bangwei Mao, Xinge Wang, Zongbao Lu, Qingtong Shan, Jin Zhang, Siqi Wang, Guihai Feng, Chenxin Wang, Chen Liang, Na Tang, Rui Niu, Jiaqiang Wang, Jiabao Han, Ning Yang, Haoyi Wang, Qi Zhou, Wei Li. All-RNA-mediated targeted gene integration in mammalian cells with rationally engineered R2 retrotransposons. Cell[J]. 2024, 第 20 作者  通讯作者  187(17): 4674-4689.e18, 
[2] Jiaqiang Wang, Yiwei Zhang, Jiaze Gao, Guihai Feng, Chao Liu, Xueke Li, Pengcheng Li, Zhonghua Liu, Falong Lu, Leyun Wang, Wei Li, Qi Zhou, Yusheng Liu. Alternative splicing of CARM1 regulated by LincGET -guided paraspeckles biases the first cell fate in mammalian early embryos. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2024, 第 11 作者  通讯作者  31(9): 1341-1354, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11402786/.
[3] Jing Xu, Jilong Ren, Kai Xu, Minghui Fang, Meina Ka, Fei Xu, Xin Wang, Jing Wang, Zhiqiang Han, Guihai Feng, Ying Zhang, Tang Hai, Wei Li, Zheng Hu. Elimination of GGTA1 , CMAH , β4GalNT2 and CIITA genes in pigs compromises human versus pig xenogeneic immune reactions. ANIMAL MODELS AND EXPERIMENTAL MEDICINE[J]. 2024, 第 13 作者  通讯作者  7(4): 584-590, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11369026/.
[4] Mao Yihuan, Wang Siqi, Yu Jiazhen, Li Wei. Engineering pluripotent stem cells with synthetic biology for regenerative medicine. MEDICAL REVIEW[J]. 2024, 第 4 作者  通讯作者  4(2): 90-109, https://doaj.org/article/4c06cb50463d478280ecf17da1027d7a.
[5] Jilong Ren, Tang Hai, Yangcan Chen, Ke Sun, Zhiqiang Han, Jing Wang, Chongyang Li, Qingwei Wang, Leyun Wang, Huabing Zhu, Dawei Yu, Wei Li, Shanjiang Zhao. Improve meat production and virus resistance by simultaneously editing multiple genes in livestock using Cas12i^(Max). SCIENCE CHINA(LIFE SCIENCES)[J]. 2024, 第 12 作者  通讯作者  67(3): 555-564, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7728147&detailType=1.
[6] Li, Fan, Karimi, Najmeh, Wang, Siqi, Pan, Tianshi, Dong, Jingxi, Wang, Xin, Ma, Sinan, Shan, Qingtong, Liu, Chao, Zhang, Ying, Li, Wei, Feng, Guihai. mRNA isoform switches during mouse zygotic genome activation. CELL PROLIFERATION[J]. 2024, 第 11 作者  通讯作者  57(7): http://dx.doi.org/10.1111/cpr.13655.
[7] Cheng Huang, Haiping Jiang, Jingxi Dong, Liyuan Jiang, Jie Li, Jing Xu, Tongtong Cui, Leyun Wang, Xin Li, Guihai Feng, Ying Zhang, Tianda Li, Wei Li, Qi Zhou. Functional mouse hepatocytes derived from interspecies chimeric livers effectively mitigate chronic liver fibrosis. STEM CELL REPORTS[J]. 2024, 第 13 作者  通讯作者  19(6): 877-889, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11390683/.
[8] Cui, Tongtong, Cai, Bingyu, Tian, Yao, Liu, Xin, Liang, Chen, Gao, Qingqin, Li, Bojin, Ding, Yali, Li, Rongqi, Zhou, Qi, Li, Wei, Teng, Fei. Therapeutic In Vivo Gene Editing Achieved by a Hypercompact CRISPR-Cas12f1 System Delivered with All-in-One Adeno-Associated Virus. ADVANCED SCIENCE[J]. 2024, 第 11 作者  通讯作者  11(19): http://dx.doi.org/10.1002/advs.202308095.
[9] Xuehan Sun, Chen Liang, Yangcan Chen, Tongtong Cui, Jiabao Han, Moyu Dai, Ying Zhang, Qi Zhou, Wei Li. Knockout and replacement gene surgery to treat rhodopsin-mediated autosomal dominant retinitis pigmentosa. Human Gene Therapy[J]. 2024, 第 9 作者  通讯作者  35(5-6): 151-162, 
[10] Dai, Moyu, Yang, Ning, Xu, Kai, Zhang, Jingwen, Li, Xueke, Zhang, Ying, Li, Wei. Discovering human cell-compatible gene therapy virus variants via optimized screening in mouse models. CELL PROLIFERATION[J]. 2024, 第 7 作者  通讯作者  57(3): e13565, http://dx.doi.org/10.1111/cpr.13565.
[11] Fei Teng, Tongtong Cui, Li Zhou, Qingqin Gao, Qi Zhou, Wei Li. Programmable synthetic receptors: the next-generation of cell and gene therapies. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2024, 第 6 作者  通讯作者  9(1): 1-25, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761793/.
[12] Dainan Yu, Haifeng Wan, Chao Tong, Lu Guang, Gang Chen, Jiali Su, Lan Zhang, Yue Wang, Zhenyu Xiao, Jinglei Zhai, Long Yan, Wenwu Ma, Kun Liang, Taoyan Liu, Yuefan Wang, Zehang Peng, Lanfang Luo, Ruoxuan Yu, Wei Li, Hongbo Qi, Hongmei Wang, Ng ShyhChang. A multi-tissue metabolome atlas of primate pregnancy. CELL[J]. 2024, 第 19 作者  通讯作者  187(3): 764-781.e14, http://dx.doi.org/10.1016/j.cell.2023.11.043.
[13] Jinglei Zhai, Yanhong Xu, Haifeng Wan, Rui Yan, Jing Guo, Robin Skory, Long Yan, Xulun Wu, Fengyuan Sun, Gang Chen, Wentao Zhao, Kunyuan Yu, Wei Li, Fan Guo, Nicolas Plachta, Hongmei Wang. Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture. CELL[J]. 2023, 第 13 作者  通讯作者  186(10): 2078-2091.e18, http://dx.doi.org/10.1016/j.cell.2023.04.019.
[14] Wenliang Zhu, Mengqi Li, Jun Zou, Da Zhang, Minghui Fang, Yun Sun, Can Li, Mingming Tang, Yukai Wang, Qi Zhou, Tongbiao Zhao, Wei Li, Zheng Hu, Baoyang Hu. Induction of local immunosuppression in allogeneic cell transplantation by cell-type-specific expression of PD-L1 and CTLA4Ig. STEM CELL REPORTS[J]. 2023, 第 12 作者  通讯作者  18(12): 2344-2355, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10724073/.
[15] Juan Yu, Nianye Yu, Yao Tian, Yifan Fang, Bin An, Guihai Feng, Jun Wu, Liu Wang, Jie Hao, Liqiang Wang, Qi Zhou, Wei Li, Yukai Wang, Baoyang Hu. Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction. CELL & BIOSCIENCE[J]. 2023, 第 12 作者  通讯作者  13(1): 201, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629087/.
[16] Wang, Chenxin, Liu, Jingjing, Li, Wei. 'Off the shelf' immunotherapies: Generation and application of pluripotent stem cell-derived immune cells. CELL PROLIFERATION[J]. 2023, 第 3 作者  通讯作者  56(4): e13425, http://dx.doi.org/10.1111/cpr.13425.
[17] Wen-Lan Yang, Weinan Qiu, Ting Zhang, Kai Xu, Zi-Juan Gu, Yu Zhou, Heng-Ji Xu, Zhong-Zhou Yang, Bin Shen, Yong-Liang Zhao, Qi Zhou, Ying Yang, Wei Li, Peng-Yuan Yang, Yun-Gui Yang. Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis. Nature Communications[J]. 2023, 第 13 作者  通讯作者  14(1): 1-16, http://dx.doi.org/10.1038/s41467-023-36595-w.
[18] Wang, Xinge, Chen, Yangcan, Cheng, Xuejia, Wang, SiQi, Hu, Yanping, Feng, Yingmei, Jin, Ronghua, Zhou, Kangping, Liu, Ti, Wang, Jianxing, Pan, Kai, Liu, Bing, Xiang, Jie, Wang, Yanping, Zhou, Qi, Zhang, Ying, Pan, Weiye, Li, Wei. CDetection.v2: One-pot assay for the detection of SARS-CoV-2. FRONTIERS IN MICROBIOLOGY[J]. 2023, 第 18 作者  通讯作者  14:1158163: http://dx.doi.org/10.3389/fmicb.2023.1158163.
[19] Ji, TianTian, Niu, ShuaiShuai, Fang, MingHui, Xu, LingXue, Wang, Xin, Wu, Jun, Xu, Fei, Zhang, Meng, Niu, Rui, Wu, Jun, Wang, Lei, Li, ZhiKun, Yang, YongGuang, Hao, Jie, Li, Wei, Hu, Zheng, Zhou, Qi. Genome editing HLA alleles for a pilot immunocompatible hESC line in a Chinese hESC bank for cell therapies. CELL PROLIFERATION[J]. 2023, 第 15 作者  通讯作者  56(5): e13471, https://www.doi.org/10.1111/cpr.13471.
[20] Wang, Chenxin, Fang, Sen, Chen, Yangcan, Tang, Na, Jiao, Guanyi, Hu, Yanping, Li, Jing, Shan, Qingtong, Wang, Xin, Feng, Guihai, Zhou, Qi, Li, Wei. High-efficiency targeted transgene integration via primed micro-homologues. CELL DISCOVERY[J]. 2023, 第 12 作者  通讯作者  9(1): 69, http://dx.doi.org/10.1038/s41421-023-00552-0.
[21] Yangcan Chen, Yanping Hu, Shengqiu Luo, Xinge Wang, Bangwei Mao, Yi Chen, Jing Xu, Zhikun Li, Qi Zhou, Wei Li. Computer-aided engineering of CRISPR-Cas proteins for enhanced human genome editing. 中国科学:生命科学英文版[J]. 2023, 第 10 作者  通讯作者  66(4): 883-886, http://lib.cqvip.com/Qikan/Article/Detail?id=7109454744.
[22] Liu, Chao, Li, Wei. Advances in haploid embryonic stem cell research(dagger). BIOLOGY OF REPRODUCTION[J]. 2022, 第 2 作者  通讯作者  107(1): 250-260, http://dx.doi.org/10.1093/biolre/ioac110.
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[24] Li, Guanglei, Li, Xiangyang, Zhuang, Songkuan, Wang, Liren, Zhu, Yifan, Chen, Yangcan, Sun, Wen, Wu, Zeguang, Zhou, Zhuo, Chen, Jia, Huang, Xingxu, Wang, Jin, Li, Dali, Li, Wei, Wang, Haoyi, Wei, Wensheng. Gene editing and its applications in biomedicine. SCIENCE CHINA-LIFE SCIENCES[J]. 2022, 第 14 作者  通讯作者  65(4): 660-700, http://dx.doi.org/10.1007/s11427-021-2057-0.
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[27] Yanping Hu, Yangcan Chen, Jing Xu, Xinge Wang, Shengqiu Luo, Bangwei Mao, Qi Zhou, Wei Li. Metagenomic discovery of novel CRISPR-Cas13 systems. CELLDISCOVERY[J]. 2022, 第 8 作者  通讯作者  8(1): 1-4, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554183/.
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[29] Jiabao Han, Liyu Zhu, Jingwen Zhang, Lu Guo, Xuehan Sun, Cheng Huang, Kai Xu, Ying Zhang, Wei Li, Qi Zhou. Rational engineering of adeno-associated virus capsid enhances human hepatocyte tropism and reduces immunogenicity. Cell Proliferation[J]. 2022, 第 9 作者  通讯作者  55(12): e13339-0, 
[30] ZhengQuan He, XueWei Yuan, ZongBao Lu, YuHuan Li, YuFei Li, Xin Liu, Liu Wang, Ying Zhang, Qi Zhou, Wei Li. Pharmacological regulation of tissue fibrosis by targeting the mechanical contraction of myofibroblasts. FUNDAMENTAL RESEARCH[J]. 2022, 第 10 作者  通讯作者  2(1): 37-47, 
[31] Lu Guo, Zhikun Li, Yuhuan Li, Bin Qu, Guanyi Jiao, Chen Liang, Zongbao Lu, XinGe Wang, Cheng Huang, Hongwei Du, Jianmin Liang, Qi Zhou, Wei Li. Treatment of Glutaric Aciduria Type I (GA-I) via Intracerebroventricular Delivery of GCDH. FUNDAMENTAL RESEARCH[J]. 2022, 第 13 作者  通讯作者  http://dx.doi.org/10.1016/j.fmre.2022.08.013.
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