李少杰  男  博导  中国科学院微生物研究所
电子邮件: lisj@im.ac.cn
通信地址: 北京北辰西路一号院3号中科院微生物所
邮政编码: 100101

研究领域

本研究组以实现真菌病害的绿色防控为目标,设立两个方向,一是通过筛选,寻找可用于真菌病害绿色防控的微生物资源,研究这些微生物的生物学特性并实现产业化;二是通过研究真菌对抗真菌药物等逆境胁迫的响应及耐受形成机制,寻找高效防控真菌病害的新靶标、新物质、新方案。

教育经历

2001-09--2005-08   University of Nebraska-Lincoln   博士学位
1994-09--1997-07   扬州大学   硕士学位
1990-09--1994-07   山西农业大学   学士学位
工作经历
1997.7 -2000.9,实习研究员 助理研究员 中国农业科学院生物防治研究所
2006.5 - 2007.5, 博士后, 美国UT-Southwestern Medical Center 生理系 
2007.6 - 2009.8, 博士后, 美国Texas A&M University 生物系 
2009.8 至今, 研究员,中国科学院微生物研究所

学术兼职
中国菌物学会菌物遗传及分子生物学专业委员会委员;菌物学报编委
学位

University of Nebraska-Lincoln -- 博士

教授课程

医学微生物学及进展
医学微生物及进展

招生信息

已指导学生

张瑜  硕士研究生  071005-微生物学  

朱菊芬  硕士研究生  071005-微生物学  

李赛飞  博士研究生  071005-微生物学  

兰楠  博士研究生  071005-微生物学  

陈曦  博士研究生  071005-微生物学  

古晓奎  博士研究生  071005-微生物学  

胡成成  博士研究生  071005-微生物学  

吴塔菊  博士研究生  071005-微生物学  

阴雅静  博士研究生  071005-微生物学  

姚雪燕  博士研究生  071005-微生物学  

现指导学生

周密  博士研究生  071007-遗传学  

曹先贺  博士研究生  071007-遗传学  

张振颖  博士研究生  071007-遗传学  

余鹏举  博士研究生  071007-遗传学  

赵彬涵  博士研究生  071007-遗传学  

研究团队

   
固定人员

孙宪昀,博士,副研究员
张振颖,硕士,高级工程师
胡成成,博士,助理研究员

合作研究伙伴
合作人1: Professor Oded Yarden, Department of Plant Pathology and Microbiology, The Hebrew University of Jerusalem,  Israel 

合作人2. Professor Steven D. Harris, Department of Plant Pathology, University of Nebraska-Lincoln, USA 

招生信息

   
招生专业
071007-遗传学
071005-微生物学
招生方向
真菌耐药机制、真菌病害绿色防控、真菌形态发育
拟招人数
2016年拟招博士、硕士研究生各一名

招生信息

   
招生专业
071007-遗传学
071005-微生物学
招生方向
真菌耐药机制
真菌病害生物防治

工作经历

   
工作简历
2009-08~现在, 中国科学院微生物研究所, 研究员
2007-06~2009-07,Texas A&M University, 博士后
2006-05~2007-05,UT-Southwestern Medical Center, 博士后
2005-09~2006-05,Norhtern Illinois University, 博士后
1997-07~2000-08,中国农业科学院生物防治研究所, 助理研究员

专利与奖励

   
专利成果
[1] 张振颖, 李少杰, 孙宪昀, 胡成成, 王旌吉. 引物组及其鉴别微白黄链霉菌W68的方法. CN: CN113444823A, 2021-09-28.
[2] 李少杰, 曹先贺, 孙宪昀, 张振颖, 胡成成. 水生产碱杆菌AS1及其在污水处理中的应用. CN: CN113215027A, 2021-08-06.
[3] 李少杰, 余鹏举, 孙宪昀, 胡成成, 张振颖. 芽生葡萄孢酵母TN29及其在污水处理中的应用. CN: CN113215008A, 2021-08-06.
[4] 李少杰, 余鹏举, 孙宪昀, 胡成成, 张振颖. 一株地霉TN42及其在污水处理中的应用. CN: CN113214999A, 2021-08-06.
[5] 李少杰, 曹先贺, 孙宪昀, 张振颖, 胡成成. 弗氏柠檬酸杆菌AS11及其在污水处理中的应用. CN: CN113151063A, 2021-07-23.
[6] 李少杰, 曹先贺, 孙宪昀, 张振颖, 胡成成. 食多种树脂假单胞菌GY13及其在污水处理中的应用. CN: CN113005063A, 2021-06-22.
[7] 黄俊, 李少杰, 姚雪燕, 张振颖, 张龙, 孙宪昀, 胡成成. 一种编码蛋白序列及其应用. CN: CN112898389A, 2021-06-04.
[8] 李少杰, 胡成成, 曹先贺, 孙宪昀, 张振颖. 一种液体发酵培养基及其应用. CN: CN112779180A, 2021-05-11.
[9] 李少杰, 胡成成, 曹先贺, 孙宪昀, 张振颖. 一株布氏乳杆菌BL4及其制备青贮饲料的方法. CN: CN112715758A, 2021-04-30.
[10] 王文昭, 白逢彦, 李少杰, 曹先贺, 任晋玮, 李二伟. 一种固相微萃取双重控温装置及方法. CN: CN112316489A, 2021-02-05.
[11] 黄俊, 李少杰, 段洪中. 一种滚筒式好氧发酵设备. CN: CN211056979U, 2020-07-21.
[12] 黄俊, 李少杰, 段洪中, 张龙, 张振颖, 杨晓燕. 一种畜禽粪污固体发酵设备及方法. CN: CN110922012A, 2020-03-27.
[13] 孙宪昀, 赵彬涵, 李少杰, 张振颖. 一株莫海威芽孢杆菌B282及其应用. CN: CN110484463A, 2019-11-22.
[14] 李少杰, 曹先贺, 孙宪昀, 张振颖. 一株副球菌B54及其应用. CN: CN110452858A, 2019-11-15.
[15] 孙宪昀, 赵彬涵, 李少杰, 张振颖. 一株解淀粉芽孢杆菌B4216及其应用. CN: CN110452859A, 2019-11-15.
[16] 孙宪昀, 李少杰, 张振颖. 一株耐酸性解淀粉芽孢杆菌Kc-5及其应用. CN: CN110452832A, 2019-11-15.
[17] 李少杰, 吴塔菊, 孙宪昀, 张振颖. 转录因子LFC1对金针菇子实体发育的调控以及应用. CN: CN110437325A, 2019-11-12.
[18] 李少杰, 曹先贺, 孙宪昀, 张振颖. 一株中间苍白杆菌B522及其应用. CN: CN110387339A, 2019-10-29.
[19] 张振颖, 张龙, 李少杰, 黄俊, 孙宪昀. 一种高通量筛选用于防治植物土传真菌病害微生物的方法. CN: CN110055303A, 2019-07-26.
[20] 李少杰, 吴塔菊, 孙宪昀, 张振颖. FvCPC2蛋白及其编码基因在调控多种食用菌菌丝生长和子实体发育中的应用. CN: CN108640983A, 2018-10-12.
[21] 李少杰, 吴塔菊, 孙宪昀, 张振颖. 调控金针菇子实体发育的转录因子PDD1及其编码基因与应用. CN: CN108558992A, 2018-09-21.
[22] 李少杰, 张振颖, 孙宪昀. 一种微白黄链霉菌菌株及其在农药中的应用. CN: CN107287130A, 2017-10-24.
[23] 刘宏伟, 李少杰, 钱韦, 张立新. 一种镰孢菌菌剂、含脂肽类化合物的农药及用途. CN: CN105981745A, 2016-10-05.
[24] 李少杰, 张振颖, 孙宪昀. 一株微白黄链霉菌及其在微生物肥料中的应用. CN: CN105886428A, 2016-08-24.
[25] 李少杰, 孙宪昀, 张振颖, 张晗星. 一种筛选以神经酰胺糖脂为作用靶标的抗真菌物质的方法. CN: CN102586394A, 2012-07-18.

出版信息

发表论文
[1] Chengcheng Hu, Mi Zhou, Xianhe Cao, Wei Xue, Zhenying Zhang, Shaojie Li, Xianyun Sun. Coordinated Regulation of Membrane Homeostasis and Drug Accumulation by Novel Kinase STK-17 in Response to Antifungal Azole Treatment. Microbiology Spectrum[J]. 2022, 10(1): e00127-22, [2] Xianhe Cao, Binhan Zhao, Yongming Wu, Jun Huang, Hongzhi Wang, Xianyun Sun, Shaojie Li. Characterization of Alcaligenes aquatilis as a novel member of heterotrophic nitrifier-aerobic denitrifier and its performance in treating piggery wastewater. Bioresource Technology[J]. 2022, 354: 127176-., [3] Yin, Yajing, Zhang, Hanxing, Zhang, Yu, Hu, Chengcheng, Sun, Xianyun, Liu, Wei, Li, Shaojie. Fungal Zn(II)(2)Cys(6) Transcription Factor ADS-1 Regulates Drug Efflux and Ergosterol Metabolism under Antifungal Azole Stress. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY[J]. 2021, 65(2): e01316-20-., https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848988/.
[4] Zhang, Kang, Zhao, Zaixu, Zhang, Ziding, Li, Yuejiao, Li, Shaojie, Yao, Nan, Hsiang, Tom, Sun, Wenxian. Insights into genomic evolution from the chromosomal and mitochondrial genomes of Ustilaginoidea virens. PHYTOPATHOLOGY RESEARCH[J]. 2021, 3(1): http://dx.doi.org/10.1186/s42483-021-00086-x.
[5] Xueyan Yao, Zhenying Zhang, Jun Huang, Shiping Wei, Xianyun Sun, Yihua Chen, Hongwei Liu, Shaojie Li. Candicidin Isomer Production Is Essential for Biocontrol of Cucumber Rhizoctonia Rot by Streptomyces albidoflavus W68. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2021, 87(9): e03078-20-., http://dx.doi.org/10.1128/AEM.03078-20.
[6] Wu, Taju, Zhang, Zhenying, Hu, Chengcheng, Zhang, Long, Wei, Shenglong, Li, Shaojie. A WD40 Protein Encoding Gene Fvcpc2 Positively Regulates Mushroom Development and Yield in Flammulina velutipes. FRONTIERS IN MICROBIOLOGY[J]. 2020, 11: https://doaj.org/article/ea345e45b1ad4297afa7dd5012a41ea9.
[7] 赵彬涵, 孙宪昀, 黄俊, 李少杰. 微生物在有机固废堆肥中的作用与应用. 微生物学通报[J]. 2020, 48(1): 223-240, http://lib.cqvip.com/Qikan/Article/Detail?id=7104294316.
[8] 余鹏举, 曹先贺, 王宏志, 李少杰. 微生物在恶臭污染治理中的研究及应用. 微生物学通报[J]. 2020, 48(1): 165-179, http://lib.cqvip.com/Qikan/Article/Detail?id=7104294312.
[9] Xu, Yueqiang, Zhou, Hui, Zhao, Guangya, Yang, Jinghua, Luo, Yuanming, Sun, Shutao, Wang, Zhongfu, Li, Shaojie, Jin, Cheng. Genetical and O-glycoproteomic analyses reveal the roles of three protein O-mannosyltransferases in phytopathogen Fusarium oxysporum f.sp. cucumerinum. FUNGAL GENETICS AND BIOLOGY[J]. 2020, 134: [10] Wu, Taju, Hu, Chengcheng, Xie, Baogui, Wei, Shenglong, Zhang, Long, Zhu, Zixiong, Zhang, Zhenying, Li, Shaojie. A putative transcription factor LFC1 negatively regulates development and yield of winter mushroom. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2020, 104(13): 5827-5844, https://www.webofscience.com/wos/woscc/full-record/WOS:000529733900001.
[11] Sun, Xianyun, Wang, Fei, Lano, Nan, Liu, Bo, Hu, Chengcheng, Xue, Wei, Zhang, Zhenying, Li, Shaojie. The Zn(II)2Cys6-Type Transcription Factor ADA-6 Regulates Conidiation, Sexual Development, and Oxidative Stress Response in Neurospora crassa. FRONTIERS IN MICROBIOLOGY[J]. 2019, 10: e750-., https://doaj.org/article/90aeb2fd67f5400381ac094eb0b74bd8.
[12] Xue, Wei, Yin, Yajing, Ismail, Fatima, Hu, Chengcheng, Zhou, Mi, Cao, Xianhe, Li, Shaojie, Sun, Xianyun. Transcription factor CCG-8 plays a pivotal role in azole adaptive responses of Neurospora crassa by regulating intracellular azole accumulation. CURRENT GENETICS[J]. 2019, 65(3): 735-745, [13] 胡成成, 余鹏举, 李少杰. 真菌中麦角甾醇合成的调控机制. 菌物研究[J]. 2019, 17(3): 138-146, http://lib.cqvip.com/Qikan/Article/Detail?id=7101033287.
[14] Wu, Taju, Hu, Chengcheng, Xie, Baogui, Zhang, Long, Yan, Shujie, Wang, Wei, Tao, Yongxin, Li, Shaojie. A Single Transcription Factor (PDD1) Determines Development and Yield of Winter Mushroom (Flammulina velutipes). APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2019, 85(24): http://dx.doi.org/10.1128/AEM.01735-19.
[15] Hu, Chengcheng, Zhou, Mi, Wang, Wenzhao, Sun, Xianyun, Yarden, Oded, Li, Shaojie. Abnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles. FRONTIERS IN MICROBIOLOGY[J]. 2018, 9: e9-, https://doaj.org/article/b68ed8c8dff04a8da8304b5ff93deea7.
[16] 刘雁霞, 李少杰, 樊振川. 粗糙脉孢菌ERG-11蛋白抗原的原核表达、纯化及其多克隆抗体制备. 生物技术通报[J]. 2017, 33(9): 216-222, [17] 王飞, 胡成成, 刘波, 李少杰, 孙宪昀. 粗糙脉孢菌无性产孢过程中增量表达基因的功能分析. 菌物学报[J]. 2017, 36(3): 311-322, [18] Chen, Xi, Xue, Wei, Zhou, Jun, Zhang, Zhenying, Wei, Shiping, Liu, Xingyu, Sun, Xianyun, Wang, Wenzhao, Li, Shaojie. De-repression of CSP-1 activates adaptive responses to antifungal azoles. SCIENTIFIC REPORTS[J]. 2016, 6: e19447-, http://dx.doi.org/10.1038/srep19447.
[19] Xiaokui Gu, Wei Xue, Yajing Yin, Hongwei Liu, Shaojie Li, Xianyun Sun. The Hsp90 co-chaperones Sti1, Aha1, and P23 regulate adaptive responses to antifungal azoles. Frontiers in Microbiology[J]. 2016, 7: e1571-, https://doaj.org/article/26b94b06a8ba4a77992bcc5ae00300ff.
[20] Gu, Xiaokui, Xue, Wei, Yin, Yajing, Liu, Hongwei, Li, Shaojie, Sun, Xianyun. The Hsp90 Co-chaperones Stil, Aha1, and P23 Regulate Adaptive Responses to Antifungal Azoles. FRONTIERS IN MICROBIOLOGY[J]. 2016, 7: e1571-, http://dx.doi.org/10.3389/fmicb.2016.01571.
[21] Chen, Bingzhi, van Peer, Arend F, Yan, Junjie, Li, Xiao, Xie, Bin, Miao, Juan, Huang, Qianhui, Zhang, Lei, Wang, Wei, Fu, Junsheng, Zhang, Xiang, Zhang, Xiaoyin, Hu, Fengli, Kong, Qingfang, Sun, Xianyun, Zou, Feng, Zhang, Hanxing, Li, Shaojie, Xie, Baogui. Fruiting Body Formation in Volvariella volvacea Can Occur Independently of Its MAT-A-Controlled Bipolar Mating System, Enabling Homothallic and Heterothallic Life Cycles. G3-GENES GENOMES GENETICS[J]. 2016, 6(7): 2135-2146, https://doaj.org/article/9cf8e7d5634540dc8ad884d5ef9e58a5.
[22] Tong, Yaojun, Liu, Mei, Zhang, Yu, Liu, Xueting, Huang, Ren, Song, Fuhang, Dai, Huanqin, Ren, Biao, Sun, Nuo, Pei, Gang, Bian, Jiang, Jia, XinMing, Huang, Guanghua, Zhou, Xuyu, Li, Shaojie, Zhang, Buchang, Fukuda, Takashi, Tomoda, Hiroshi, Omura, Satoshi, Cannon, Richard D, Calderone, Richard, Zhang, Lixin. Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2016, 1(3): 158-168, http://lib.cqvip.com/Qikan/Article/Detail?id=7103844692.
[23] Yan, JunJie, Xie, Bin, Zhang, Lei, Li, ShaoJie, van Peer, Arend F, Wu, TaJu, Chen, BingZhi, Xie, BaoGui. Small GTPases and Stress Responses of vvran1 in the Straw Mushroom Volvariella volvacea. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2016, 17(9): https://doaj.org/article/0955b841d7a74f3a84f76408bf3688d8.
[24] Wang, Wei, Chen, Bingzhi, Zhang, Lei, Yan, Junjie, Lu, Yuanping, Zhang, Xiaoyin, Jiang, Yuji, Wu, Taju, van Peer, Arend Frans, Li, Shaojie, Xie, Baogui. Structural Variation (SV) Markers in the Basidiomycete Volvariella volvacea and Their Application in the Construction of a Genetic Map. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2015, 16(7): 16669-16682, https://doaj.org/article/64aa707dc5ca4081ba18bfa3ca6eaa1d.
[25] 连玲丹, 吴小婷, 卢园萍, 张磊, 谢斌, 陈仁良, 吴塔菊, 李少杰, 谢宝贵. 与草菇原基形成相关的过氧化物酶基因VvDyP的结构与表达分析. 菌物学报[J]. 2015, 34(4): 734-741, [26] 陈仁良, 严俊杰, 陶永新, 谢斌, 张磊, 吴塔菊, 李少杰, 谢宝贵. 草菇翻译起始因子Vv-IF4E及与其共表达转录因子的研究. 菌物学报[J]. 2015, 34(4): 703-711, [27] 胡成成, 孙宪昀, 陈曦, 李少杰. 真菌对唑类抗真菌药物的耐受机制. 菌物学报[J]. 2015, 34(5): 927-941, [28] Yue, Qun, Chen, Li, Li, Yan, Bills, Gerald F, Zhang, Xinyu, Xiang, Meichun, Li, Shaojie, Che, Yongsheng, Wang, Chengshu, Niu, Xuemei, An, Zhiqiang, Liu, Xingzhong. Functional Operons in Secondary Metabolic Gene Clusters in Glarea lozoyensis (Fungi, Ascomycota, Leotiomycetes). MBIO[J]. 2015, 6(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000357867400071.
[29] Wang, Kangji, Zhang, Zhenying, Chen, Xi, Sun, Xianyun, Jin, Cheng, Liu, Hongwei, Li, Shaojie. Transcription Factor ADS-4 Regulates Adaptive Responses and Resistance to Antifungal Azole Stress. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY[J]. 2015, 59(9): 5396-5404, http://dx.doi.org/10.1128/AAC.00542-15.
[30] Lu, Yuanping, Lian, Lingdan, Guo, Lixian, Xie, Bin, Wang, Wei, Chen, Bingzhi, van Peer, Arend Frans, Li, Shaojie, Wu, Taju, Xie, Baogui. The Accordant Trend of Both Parameters (rgs Expression and cAMP Content) Follows the Pattern of Development of Fruiting Body in Volvariella volvacea. CURRENT MICROBIOLOGY[J]. 2015, 71(5): 579-584, https://www.webofscience.com/wos/woscc/full-record/WOS:000361800500008.
[31] 王威, 丑天胜, 刘芳, 严俊杰, 吴塔菊, 李少杰, 谢宝贵. 金针菇单、双核菌丝差异表达基因分析. 菌物学报[J]. 2015, 34(4): 683-693, [32] Sun, Xianyun, Wang, Kangji, Yu, Xinxu, Liu, Jie, Zhang, Hanxing, Zhou, Fucai, Xie, Baogui, Li, Shaojie. Transcription Factor CCG-8 as a New Regulator in the Adaptation to Antifungal Azole Stress. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY[J]. 2014, 58(3): 1434-1442, http://dx.doi.org/10.1128/AAC.02244-13.
[33] Zhang, Yong, Zhang, Kang, Fang, Anfei, Han, Yanqing, Yang, Jun, Xue, Minfeng, Bao, Jiandong, Hu, Dongwei, Zhou, Bo, Sun, Xianyun, Li, Shaojie, Wen, Ming, Yao, Nan, Ma, LiJun, Liu, Yongfeng, Zhang, Min, Huang, Fu, Luo, Chaoxi, Zhou, Ligang, Li, Jianqiang, Chen, Zhiyi, Miao, Jiankun, Wang, Shu, Lai, Jinsheng, Xu, JinRong, Hsiang, Tom, Peng, YouLiang, Sun, Wenxian. Specific adaptation of Ustilaginoidea virens in occupying host florets revealed by comparative and functional genomics. NATURE COMMUNICATIONS[J]. 2014, 5: https://www.webofscience.com/wos/woscc/full-record/WOS:000337373800001.
[34] Tao, Yongxin, van Peer, Arend F, Chen, Bingzhi, Chen, Zhihong, Zhu, Jian, Deng, Youjin, Jiang, Yuji, Li, Shaojie, Wu, Taju, Xie, Baogui. Gene Expression Profiling Reveals Large Regulatory Switches between Succeeding Stipe Stages in Volvariella volvacea. PLOS ONE[J]. 2014, 9(5): https://doaj.org/article/1c98c2662c5a4c459bc20aa116a97a48.
[35] Zhang, Zhenyu, Yang, Qiuying, Sun, Guangyan, Chen, She, He, Qun, Li, Shaojie, Liu, Yi. Histone H3K56 Acetylation Is Required for Quelling-induced Small RNA Production through Its Role in Homologous Recombination. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2014, 289(13): 9365-9371, http://dx.doi.org/10.1074/jbc.M113.528521.
[36] Li, SaiFei, Xi, YaLi, Qi, CaiXia, Liang, QianQian, Wei, ShengLong, Li, GuoJie, Zhao, Dong, Li, ShaoJie, Wen, HuaAn. Agaricus taeniatus sp nov., a new member of Agaricus sect. Bivelares from northwest China. MYCOTAXON[J]. 2014, 129(1): 187-196, https://www.webofscience.com/wos/woscc/full-record/WOS:000348496800022.
[37] Lan, Nan, Zhang, Hanxing, Hu, Chengcheng, Wang, Wenzhao, Calvo, Ana M, Harris, Steven D, Chen, She, Li, Shaojie. Coordinated and Distinct Functions of Velvet Proteins in Fusarium verticillioides. EUKARYOTIC CELL[J]. 2014, 13(7): 909-918, https://www.webofscience.com/wos/woscc/full-record/WOS:000338767900007.
[38] Zhang, Zhenyu, Chang, ShwuShin, Zhang, Zhenying, Xue, Zhihong, Zhang, Hanxing, Li, Shaojie, Liu, Yi. Homologous recombination as a mechanism to recognize repetitive DNA sequences in an RNAi pathway. GENES & DEVELOPMENT[J]. 2013, 27(2): 145-150, https://www.webofscience.com/wos/woscc/full-record/WOS:000314044800003.
[39] Chen, Li, Yue, Qun, Zhang, Xinyu, Xiang, Meichun, Wang, Chengshu, Li, Shaojie, Che, Yongsheng, OrtizLopez, Francisco Javier, Bills, Gerald F, Liu, Xingzhong, An, Zhiqiang. Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis. BMC GENOMICS[J]. 2013, 14(1): 339-339, http://dx.doi.org/10.1186/1471-2164-14-339.
[40] Yang, Qiuying, Li, Liande, Xue, Zhihong, Ye, Qiaohong, Zhang, Lin, Li, Shaojie, Liu, Yi. Transcription of the Major Neurospora crassa microRNA-Like Small RNAs Relies on RNA Polymerase III. PLOS GENETICS[J]. 2013, 9(1): https://doaj.org/article/14568b8716354fbbb3dfbe6f093062ce.
[41] Chen, Bingzhi, Gui, Fu, Xie, Baogui, Deng, Youjin, Sun, Xianyun, Lin, Mengying, Tao, Yongxin, Li, Shaojie. Composition and Expression of Genes Encoding Carbohydrate-Active Enzymes in the Straw-Degrading Mushroom Volvariella volvacea. PLOS ONE[J]. 2013, 8(3): https://doaj.org/article/95617928aad44d23b244a448aeef8330.
[42] Wang, Shaojuan, Bao, Li, Han, Junjie, Wang, Quanxin, Yang, Xiaoli, Wen, Huaan, Guo, Liangdong, Li, Shaojie, Zhao, Feng, Liu, Hongwei. Pleurospiroketals A-E, Perhydrobenzannulated 5,5-Spiroketal Sesquiterpenes from the Edible Mushroom Pleurotus cornucopiae. JOURNAL OF NATURAL PRODUCTS[J]. 2013, 76(1): 45-50, http://dx.doi.org/10.1021/np3006524.
[43] 孙宪昀, 朱菊芬, 宝丽, 胡成成, 金城, Harris Steven D, 刘宏伟, 李少杰. 过量尿嘧啶胁迫下pyrG对维持构巢曲霉胞内尿嘧啶稳定及正常产孢起关键作用. 中国科学. 生命科学[J]. 2013, 43(5): 387-396, [44] Wang, Shaojuan, Bao, Li, Zhao, Feng, Wang, Quanxin, Li, Shaojie, Ren, Jinwei, Li, Li, Wen, Huaan, Guo, Liangdong, Liu, Hongwei. Isolation, Identification, and Bioactivity of Monoterpenoids and Sesquiterpenoids from the Mycelia of Edible Mushroom Pleurotus cornucopiae. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2013, 61(21): 5122-5129, http://dx.doi.org/10.1021/jf401612t.
[45] Han, JunJie, Bao, Li, He, LuWei, Zhang, XiaoQing, Yang, XiaoLi, Li, ShaoJie, Yao, YiJian, Liu, Hongwei. Phaeolschidins A-E, Five Hispidin Derivatives with Antioxidant Activity from the Fruiting Body of Phaeolus schweinitzii Collected in the Tibetan Plateau. JOURNAL OF NATURAL PRODUCTS[J]. 2013, 76(8): 1448-1453, http://dx.doi.org/10.1021/np400234u.
[46] Bingzhi Chen, Fu Gui, Baogui Xie, Youjin Deng, Xianyun Sun, Mengying Lin, Yongxin Tao, Shaojie Li. Correction: Composition and Expression of Genes Encoding Carbohydrate-Active Enzymes in the Straw-Degrading Mushroom Volvariella volvacea. PLoS ONE[J]. 2013, 8(9): https://doaj.org/article/fb48c108d0e348edb681cb889b039d26.
[47] Sun, Xianyun, Wang, Wenzhao, Wang, Kangji, Yu, Xinxu, Liu, Jie, Zhou, Fucai, Xie, Baogui, Li, Shaojie, 孙宪昀. Sterol C-22 desaturase ERG5 mediates the sensitivity to antifungal azoles in Neurospora crassa and Fusarium verticillioides. FRONTIERS IN MICROBIOLOGY[J]. 2013, 4: e127-., http://dx.doi.org/10.3389/fmicb.2013.00127.
[48] Sun, Xianyun, Kang, Shu, Zhang, Yongjie, Tan, Xinqiu, Yu, Yufei, He, Haiyong, Zhang, Xinyu, Liu, Yongfeng, Wang, Shu, Sun, Wenxian, Cai, Lei, Li, Shaojie, 孙宪昀. Genetic Diversity and Population Structure of Rice Pathogen Ustilaginoidea virens in China. PLOS ONE[J]. 2013, 8(9): e76879-., http://dx.doi.org/10.1371/journal.pone.0076879.
[49] Sun XianYun, Zhu JuFen, Bao Li, Hu ChengCheng, Jin Cheng, Harris, Steven D, Liu HongWei, Li ShaoJie. pyrG is required for maintaining stable cellular uracil level and normal sporulation pattern under excess uracil stress in Aspergillus nidulans. SCIENCE CHINA-LIFE SCIENCES[J]. 2013, 56(5): 467-475, https://www.webofscience.com/wos/woscc/full-record/WOS:000318308100011.
[50] Wang, QuanXin, Bao, Li, Yang, XiaoLi, Liu, DaiLin, Guo, Hui, Dai, HuanQin, Song, FuHang, Zhang, LiXin, Guo, LiangDong, Li, ShaoJie, Liu, HongWei. Ophiobolins P-T, five new cytotoxic and antibacterial sesterterpenes from the endolichenic fungus Ulocladium sp.. FITOTERAPIA[J]. 2013, 90: 220-227, https://www.webofscience.com/wos/woscc/full-record/WOS:000326427600027.
[51] Zhu, Jufen, Yu, Xinxu, Xie, Baogui, Gu, Xiaokui, Zhang, Zhenying, Li, Shaojie. Transcriptomic profiling-based mutant screen reveals three new transcription factors mediating menadione resistance in Neurospora crassa. FUNGAL BIOLOGY[J]. 2013, 117(6): 422-430, http://dx.doi.org/10.1016/j.funbio.2013.04.006.
[52] Han, JunJie, Chen, YuHui, Bao, Li, Yang, XiaoLi, Liu, Dailin, Li, ShaoJie, Zhao, Feng, Liu, Hongwei. Anti-inflammatory and cytotoxic cyathane diterpenoids from the medicinal fungus Cyathus africanus. FITOTERAPIA[J]. 2013, 84: 22-31, http://dx.doi.org/10.1016/j.fitote.2012.10.001.
[53] Xianyun Sun, Shu Kang, Yongjie Zhang, Xinqiu Tan, Yufei Yu, Haiyong He, Xinyu Zhang, Yongfeng Liu, Shu Wang, Wenxian Sun, Lei Cai, Shaojie Li. Correction: Genetic Diversity and Population Structure of Rice Pathogen Ustilaginoidea virens in China. PLoS ONE[J]. 2013, 8(12): https://doaj.org/article/84a72f3c45304472a8e955443704787f.
[54] Sun, Xianyun, Yu, Luning, Lan, Nan, Wei, Shiping, Yu, Yufei, Zhang, Hanxing, Zhang, Xinyu, Li, Shaojie. Analysis of the role of transcription factor VAD-5 in conidiation of Neurospora crassa. FUNGAL GENETICS AND BIOLOGY[J]. 2012, 49(5): 379-387, http://dx.doi.org/10.1016/j.fgb.2012.03.003.
[55] Wang, Shaojuan, Li, Yongxia, Bao, Li, Han, Junjie, Yang, Xiaoji, Li, Heran, Wang, Yaqi, Li, Shaojie, Liu, Hongwei. Eryngiolide A, a Cytotoxic Macrocyclic Diterpenoid with an Unusual Cyclododecane Core Skeleton Produced by the Edible Mushroom Pleurotus eryngii. ORGANIC LETTERS[J]. 2012, 14(14): 3672-3675, http://dx.doi.org/10.1021/ol301519m.
[56] Zhang, Yu, Zhang, Zhenying, Zhang, Xinyu, Zhang, Hanxing, Sun, Xianyun, Hu, Chengcheng, Li, Shaojie. CDR4 is the major contributor to azole resistance among four Pdr5p-like ABC transporters in Neurospora crassa. FUNGAL BIOLOGY[J]. 2012, 116(7): 848-854, http://dx.doi.org/10.1016/j.funbio.2012.05.002.
[57] Sun, Xianyun, Zhang, Hanxing, Zhang, Zhenying, Wang, Yong, Li, Shaojie. Involvement of a helix-loop-helix transcription factor CHC-1 in CO2-mediated conidiation suppression in Neurospora crassa. FUNGAL GENETICS AND BIOLOGY[J]. 2011, 48(12): 1077-1086, http://dx.doi.org/10.1016/j.fgb.2011.09.003.
[58] Wang, Jiyong, Hu, Qiwen, Chen, Huijie, Zhou, Zhipeng, Li, Weihua, Wang, Ying, Li, Shaojie, He, Qun. Role of Individual Subunits of the Neurospora crassa CSN Complex in Regulation of Deneddylation and Stability of Cullin Proteins. PLOS GENETICS[J]. 2010, 6(12): http://124.16.144.217/handle/311023/2263.
[59] Tang, ChiTai, Li, Shaojie, Long, Chengzu, Cha, Joonseok, Huang, Guocun, Li, Lily, Chen, She, Liu, Yi. Setting the pace of the Neurospora circadian clock by multiple independent FRQ phosphorylation events. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2009, 106(26): 10722-10727, http://124.16.144.217/handle/311023/1425.
[60] Li Shaojie, Calvo Ana M, Yuen Gary Y, Du Liangcheng, Harris Steven D. Induction of cell wall thickening by the antifungal compound dihydromaltophilin disrupts fungal growth and is mediated by sphingolipid biosynthesis.. The Journal of eukaryotic microbiology. 2009, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPD12102101809365&DbName=SJPD_02&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[61] 李少杰. An antifbiotic complex from Lysobacter enzymogenes strain C3: antimicrobial activity and role in plant disease control. Phytopathology. 2008, [62] Li, Shaojie, Bao, Dapeng, Yuen, Gary, Harris, Steve D, Calvo, Ana M. basA regulates cell wall organization and asexual/sexual sporulation ratio in Aspergillus nidulans. GENETICS[J]. 2007, 176(1): 243-253, https://www.webofscience.com/wos/woscc/full-record/WOS:000246960900021.
[63] Li, SJ, Du, LC, Yuen, G, Harris, SD. Distinct ceramide synthases regulate polarized growth in the filamentous fungus Aspergillus nidulans. MOLECULAR BIOLOGY OF THE CELL[J]. 2006, 17(3): 1218-1227, https://www.webofscience.com/wos/woscc/full-record/WOS:000235790100016.
[64] Li, Shaojie, Myung, Kyung, Guse, Diana, Donkin, Brett, Proctor, Robert H, Grayburn, W Scott, Calvo, Ana M. FvVE1 regulates filamentous growth, the ratio of microconidia to macroconidia and cell wall formation in Fusarium verticillioides. MOLECULAR MICROBIOLOGY[J]. 2006, 62(5): 1418-1432, https://www.webofscience.com/wos/woscc/full-record/WOS:000241832000016.

科研活动

   
科研项目
( 1 ) 转录因子ADS-1介导的对唑类抗真菌药物的适应性响应机制, 主持, 国家级, 2017-01--2020-12
( 2 ) 畜禽养殖废弃物二次发酵过程中功能物质形成及调控机制, 主持, 国家级, 2018-06--2020-12
( 3 ) 一种促生防病微生物肥的研发, 主持, 院级, 2016-07--2021-06
( 4 ) 一种饲料添加用微生物制剂的研发, 主持, 院级, 2016-07--2021-06
( 5 ) 杂交构树全株青储发酵工艺研制及全日粮饲料生产, 主持, 部委级, 2019-01--2020-12
( 6 ) 农业有机废弃物资源化产品的研发, 主持, 院级, 2019-06--2024-05
( 7 ) 粗糙脉胞菌NDR激酶COT1对膜组分麦角甾醇和鞘磷脂合成调控机制研究, 主持, 国家级, 2014-10--2017-10
( 8 ) 食用菌子实体形成发育的调控机理, 主持, 国家级, 2014-01--2018-12
( 9 ) 放线菌Hb-2中植物防御素RsAFP2机制类物的鉴定及合成调控机理分析, 主持, 国家级, 2014-01--2017-12
( 10 ) 粗糙脉胞菌转录因子ADA-1调控有性发育的机制研究, 主持, 国家级, 2012-01--2015-12
( 11 ) 粗糙脉孢菌中含WD40重复序列蛋白CPC-2对原子囊果发育的调控机制, 主持, 国家级, 2020-01--2023-12
( 12 ) 一种复合微生物菌剂的改进与综合应用技术开发, 主持, 院级, 2019-11--2021-11
( 13 ) 芽孢杆菌Kc-5发酵技术与菌剂研发, 主持, 省级, 2021-04--2024-03
( 14 ) 微白黄链霉菌W68发酵技术与菌剂研发, 主持, 省级, 2019-09--2021-12
( 15 ) 农牧、食品及污水处理用系列微生物产品的研发, 主持, 院级, 2021-07--2031-06
参与会议
(1)Regulation of fruiting body development in Winter mushroom   亚洲真菌学大会   2019-10-01
(2)真菌对唑类抗菌药物的应答机制   海峡两岸真菌学学术研讨会   2015-11-07
(3)A novel fungal transcription factor ADS-1 regulates azole resistance and virulence   亚洲菌物学大会   2013-08-24