基本信息
李国红 男 博导 生物物理研究所
电子邮件:liguohong@sun5.ibp.ac.cn
通信地址:北京市朝阳区大屯路15号
邮政编码:100101

研究领域

染色质结构和表观遗传调控

招生信息

2012年计划招收2名硕博生
招生专业:生物化学和分子生物学


招生方向
染色质结构和基因表达调控的生物学研究

教育背景

   
学历
1991-1995:武汉大学病毒系,本科
1995-1998:北京医科大学基础医学院生物物理系,硕士研究生
1998-2003:德国马普细胞生物学研究所/海德堡大学,博士研究生
学位
1995:武汉大学病毒系,学士学位
1998:北京医科大学基础医学院生物物理系,硕士学位
2003:德国海德堡大学生物系, 博士学位

工作经历

2003-2006:美国新泽西医科大学生物化学系/霍华德.休斯医学研究院,Danny Reinberg实验室博士后
2006-2009:美国纽约大学医学院生物化学系/霍华德.休斯医学研究院,Danny Reinberg实验室博士后
2009-current:中国科学院生物物理研究所,“****”研究员,博士生导师

专利与奖励

   
专利成果
[1] 李国红, 俞洋, 包新华, 胡明丽, 王胜, 章清萍, 阮海荷. 特异性结合H1.4移码突变蛋白的单克隆抗体制备及其应用. CN113480646B, 2022-03-15.

出版信息

   
发表论文
[1] Wang, YiZhou, Liu, Cuifang, Zhao, Jicheng, Yu, Juan, Luo, Anfeng, Xiao, Xue, Dou, ShuoXing, Ma, Lu, Wang, PengYe, Li, Ming, Li, Guohong, Yan, Jianbin, Chen, Ping, Li, Wei. H2A mono-ubiquitination differentiates FACT's functions in nucleosome assembly and disassembly. NUCLEIC ACIDS RESEARCH[J]. 2022, 50(2): 833-846, http://dx.doi.org/10.1093/nar/gkab1271.
[2] Liu, Yuting, Wang, Kehui, Huang, Li, Zhao, Jicheng, Chen, Xinpeng, Wu, Qiang, Yu, Zhouliang, Li, Guohong. Ser68 phosphoregulation is essential for CENP-A deposition, centromere function and viability in mice. SCIENCE CHINA-LIFE SCIENCES. 2022, 65: http://dx.doi.org/10.1007/s11427-021-2077-1.
[3] Huo, Dawei, Yu, Zhaowei, Li, Rui, Gong, Meihan, Sidoli, Simone, Lu, Xukun, Hou, Yuying, Dai, Zhongye, Kong, Yu, Liu, Guifen, Jensen, Ole N, Xie, Wei, Helin, Kristian, Xiong, Chaoyang, Li, Guohong, Zhang, Yong, Wu, Xudong. CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency. MOLECULAR CELL[J]. 2022, 82(6): 1169-+, http://dx.doi.org/10.1016/j.molcel.2022.01.027.
[4] Wang, Kehui, Liu, Yuting, Yu, Zhouliang, Gu, Bo, Hu, Jie, Huang, Li, Ge, Xiao, Xu, Lingyi, Zhang, Mengyu, Zhao, Jicheng, Hu, Mingli, Le, Rongrong, Wu, Qiang, Ye, Sheng, Gao, Shaorong, Zhang, Xiaodong, Xu, RuiMing, Li, Guohong. Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle. CELL REPORTS[J]. 2021, 37(6): http://dx.doi.org/10.1016/j.celrep.2021.109987.
[5] Yu, Juan, Xiong, Chaoyang, Zhuo, Baowen, Wen, Zengqi, Shen, Jie, Liu, Cuifang, Chang, Luyuan, Wang, Kehui, Wang, Min, Wu, Chenyi, Wu, Xudong, Xu, Xueqin, Ruan, Haihe, Li, Guohong. Analysis of Local Chromatin States Reveals Gene Transcription Potential during Mouse Neural Progenitor Cell Differentiation. CELL REPORTS[J]. 2020, 32(4): https://doaj.org/article/535649a3840e43bc8bcee137095351da.
[6] Zhao, Jicheng, Wang, Min, Chang, Luyuan, Yu, Juan, Song, Aoqun, Liu, Cuifang, Huang, Wenjun, Zhang, Tiantian, Wu, Xudong, Shen, Xiaohua, Zhu, Bing, Li, Guohong. RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division. NATURE CELL BIOLOGY[J]. 2020, 22(4): http://dx.doi.org/10.1038/s41556-020-0484-1.
[7] Xiao, Xue, Liu, Cuifang, Pei, Yingxin, Wang, YiZhou, Kong, Jingwei, Lu, Ke, Ma, Lu, Dou, ShuoXing, Wang, PengYe, Li, Guohong, Chen, Ping, Li, Wei. Histone H2A Ubiquitination Reinforces Mechanical Stability and Asymmetry at the Single-Nucleosome Level. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 142(7): 3340-3345, http://dx.doi.org/10.1021/jacs.9b12448.
[8] 李国红. Structures and Functions of Chromatin Fibers.. Annu. Rev. Biophys. 2020, [9] Wen, Zengqi, Zhang, Liwei, Ruan, Haihe, Li, Guohong. Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(11): 5939-5952, http://dx.doi.org/10.1093/nar/gkaa360.
[10] Long, Haizhen, Zhang, Liwei, Lv, Mengjie, Wen, Zengqi, Zhang, Wenhao, Chen, Xiulan, Zhang, Peitao, Li, Tongqing, Chang, Luyuan, Jin, Caiwei, Wu, Guozhao, Wang, Xi, Yang, Fuquan, Pei, Jianfeng, Chen, Ping, Margueron, Raphael, Deng, Haiteng, Zhu, Mingzhao, Li, Guohong. H2A.Z facilitates licensing and activation of early replication origins. NATURE[J]. 2020, 577(7791): 576-+, http://dx.doi.org/10.1038/s41586-019-1877-9.
[11] Wang, Liang, Hu, Mingli, Zuo, MeiQing, Zhao, Jicheng, Wu, Di, Huang, Li, Wen, Yongxin, Li, Yunfan, Chen, Ping, Bao, Xinhua, Dong, MengQiu, Li, Guohong, Li, Pilong. Rett syndrome-causing mutations compromise MeCP2-mediated liquid-liquid phase separation of chromatin. CELL RESEARCH[J]. 2020, 30(5): 393-407, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196128/.
[12] Xiong, Chaoyang, Wen, Zengqi, Yu, Juan, Chen, Jun, Liu, ChaoPei, Zhang, Xiaodong, Chen, Ping, Xu, RuiMing, Li, Guohong. UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis- regulatory elements of genes in mouse ES cells. BMC BIOLOGY[J]. 2018, 16(1): http://dx.doi.org/10.1186/s12915-018-0573-9.
[13] 李国红. H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition in mES cells.. BMC. 2018, [14] Chen, Ping, Dong, Liping, Hu, Mingli, Wang, YiZhou, Xiao, Xue, Zhao, Zhongliang, Yan, Jie, Wang, PengYe, Reinberg, Danny, Li, Ming, Li, Wei, Li, Guohong. Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level. MOLECULAR CELL[J]. 2018, 71(2): 284-+, http://dx.doi.org/10.1016/j.molcel.2018.06.020.
[15] Xiao Xue, Dong Liping, Wang Yizhou, Wang Pengye, Li Ming, Li Guohong, Chen Ping, Li Wei. Dissection of structural dynamics of chromatin fibers by single-molecule magnetic tweezers. 生物物理学报:英文版[J]. 2018, 4(4): 222-232, http://lib.cqvip.com/Qikan/Article/Detail?id=676327040.
[16] Li, Wei, Chen, Ping, Yu, Juan, Dong, Liping, Liang, Dan, Feng, Jianxun, Yan, Jie, Wang, PengYe, Li, Qing, Zhang, Zhiguo, Li, Ming, Li, Guohong. FACT Remodels the Tetranucleosomal Unit of Chromatin Fibers for Gene Transcription. MOLECULAR CELL[J]. 2016, 64(1): 120-133, http://dx.doi.org/10.1016/j.molcel.2016.08.024.
[17] 李国红. Dissecting the precise role of histone H3 K9 methylation in crosstalk with DNA maintenance methylation in mammalian cells.. Nature Communications. 2016, [18] Zhu, Ping, Li, Guohong. Structural insights of nucleosome and the 30-nm chromatin fiber. CURRENT OPINION IN STRUCTURAL BIOLOGY[J]. 2016, 36: 106-115, http://dx.doi.org/10.1016/j.sbi.2016.01.013.
[19] Xiong, Chaoyang, Wen, Zengqi, Li, Guohong. Histone Variant H3.3: A versatile H3 variant in health and in disease. SCIENCE CHINA-LIFE SCIENCES[J]. 2016, 59(3): 245-256, http://dx.doi.org/10.1007/s11427-016-5006-9.
[20] Qianglin Fang. Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome. eLife Sciences Publications, Ltd. 2016, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201904022729925ZK.
[21] 李国红. Structural Transitions of Centromeric Chromatin Coordinate the Cell Cycle-dependent Recruitment of CENP-N.. Genes and Development. 2015, [22] Yu, Zhouliang, Zhou, Xiang, Wang, Wenjing, Deng, Wenqiang, Fang, Junnan, Hu, Hao, Wang, Zichen, Li, Shangze, Cui, Lei, Shen, Jing, Zhai, Linhui, Peng, Shengyi, Wong, Jiemin, Dong, Shuo, Yuan, Zengqiang, Ou, Guangshuo, Zhang, Xiaodong, Xu, Ping, Lou, Jizhong, Yang, Na, Chen, Ping, Xu, RuiMing, Li, Guohong. Dynamic Phosphorylation of CENP-A at Ser68 Orchestrates Its Cell-Cycle-Dependent Deposition at Centromeres. DEVELOPMENTAL CELL[J]. 2015, 32(1): 68-81, http://dx.doi.org/10.1016/j.devcel.2014.11.030.
[23] Zhao, Hongyu, Xing, Yongqiang, Liu, Guoqing, Chen, Ping, Zhao, Xiujuan, Li, Guohong, Cai, Lu. GAA triplet-repeats cause nucleosome depletion in the human genome. GENOMICS[J]. 2015, 106(2): 88-95, http://dx.doi.org/10.1016/j.ygeno.2015.06.010.
[24] Song, Feng, Chen, Ping, Sun, Dapeng, Wang, Mingzhu, Dong, Liping, Liang, Dan, Xu, RuiMing, Zhu, Ping, Li, Guohong. Cryo-EM Study of the Chromatin Fiber Reveals a Double Helix Twisted by Tetranucleosomal Units. SCIENCE[J]. 2014, 344(6182): 376-380, https://www.webofscience.com/wos/woscc/full-record/WOS:000334867800032.
[25] 李国红. Variant histone H3.3 functionally counteracts with H2A.Z to activate gene transcription.. Genes and Development. 2013, [26] Liu, ChaoPei, Xiong, Chaoyang, Wang, Mingzhu, Yu, Zhouliang, Yang, Na, Chen, Ping, Zhang, Zhiguo, Li, Guohong, Xu, RuiMing. Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2012, 19(12): 1287-+, http://dx.doi.org/10.1038/nsmb.2439.
[27] Li, Guohong, Reinberg, Danny. Chromatin higher-order structures and gene regulation. CURRENT OPINION IN GENETICS & DEVELOPMENT[J]. 2011, 21(2): 175-186, http://dx.doi.org/10.1016/j.gde.2011.01.022.
[28] Hu, Hao, Liu, Yang, Wang, Mingzhu, Fang, Junnan, Huang, Hongda, Yang, Na, Li, Yanbo, Wang, Jianyu, Yao, Xuebiao, Shi, Yunyu, Li, Guohong, Xu, RuiMing. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. GENES & DEVELOPMENT[J]. 2011, 25(9): 901-906, http://www.irgrid.ac.cn/handle/1471x/757447.
[29] Chen, Ping, Li, Guohong. Dynamics of the higher-order structure of chromatin. PROTEIN & CELL[J]. 2010, 1(11): 967-971, https://www.webofscience.com/wos/woscc/full-record/WOS:000208511800002.
[30] Guohong Li, Raphael Margueron, Guobin Hu, David Stokes, YuhHwa Wang, Danny Reinberg. Highly Compacted Chromatin Formed in vitro Reflect the Dynamics of Transcription Activation in vivo. Molecular cell. 2010, 38(1): 41-53, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641559/.
[31] 李国红. The Program for Processing Replicative Histones H3.1 and H4: from the Cytoplasm to the Nucleus.. Nature Structural and Molecular Biology. 2010, [32] Schutte, B, Henfling, M E R, Verheyen, F K C P, Li, G, Tolstonog, G V, Ramaekers, F C S. The caspase-9 derived C-terminal fragment of cytokeratin 18 modulates topoisomerase action. INTERNATIONAL JOURNAL OF ONCOLOGY[J]. 2009, 35(3): 625-630, https://www.webofscience.com/wos/woscc/full-record/WOS:000268736400018.
[33] Margueron, Raphael, Li, Guohong, Sarma, Kavitha, Blais, Alexandre, Zavadil, Jiri, Woodcock, Christopher L, Dyniacht, Brian D, Reinberg, Danny. Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms. MOLECULAR CELL[J]. 2008, 32(4): 503-518, http://dx.doi.org/10.1016/j.molcel.2008.11.004.
[34] Trojer, Patrick, Li, Guohong, Sims, Robert J, III, Vaquero, Alejandro, Kalakonda, Nagesh, Boccuni, Piernicola, Lee, Donghoon, ErdjumentBromage, Hediye, Tempst, Paul, Nimer, Stephen D, Wang, YuhHwa, Reinberg, Danny. L3MBTL1, a histone-methylation-dependent chromatin lock. CELL[J]. 2007, 129(5): 915-928, http://dx.doi.org/10.1016/j.cell.2007.03.048.
[35] Pavri, Rushad, Zhu, Bing, Li, Guohong, Trojer, Patrick, Mandal, Subhrangsu, Shilatifard, Ali, Reinberg, Danny. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. CELL[J]. 2006, 125(4): 703-717, http://dx.doi.org/10.1016/j.cell.2006.04.029.
[36] Sims, Robert J, III, Trojer, Patrick, Li, Guohong, Reinberg, Danny. Methods to identify and functionally analyze factors that specifically recognize histone lysine methylation. METHODS[J]. 2006, 40(4): 331-338, http://dx.doi.org/10.1016/j.ymeth.2006.07.031.
[37] Tolstonog, GV, Li, GH, Shoeman, RL, Traub, P. Interaction in vitro of type III intermediate filament proteins with higher order structures of single-stranded DNA, particularly with G-quadruplex DNA. DNA AND CELL BIOLOGYnull. 2005, 24(2): 85-110, https://www.webofscience.com/wos/woscc/full-record/WOS:000226839600003.
[38] Li, GH, Tolstonog, GV, Sabasch, M, Traub, P. Type III intermediate filament proteins interact with four-way junction DNA and facilitate its cleavage by the junction-resolving enzyme T7 endonuclease I. DNA AND CELL BIOLOGYnull. 2003, 22(4): 261-291, https://www.webofscience.com/wos/woscc/full-record/WOS:000183354800006.
[39] Li, GH, Tolstonog, GV, Traub, P. Interaction in vitro of type III intermediate filament proteins with Z-DNA and B-Z-DNA junctions. DNA AND CELL BIOLOGYnull. 2003, 22(3): 141-169, https://www.webofscience.com/wos/woscc/full-record/WOS:000182803700001.
[40] Li, GH, Tolstonog, GV, Traub, P. Interaction in vitro of type III intermediate filament proteins with triplex DNA. DNA AND CELL BIOLOGYnull. 2002, 21(3): 163-188, [41] Li, GH, Tolstonog, GV, Sabasch, M, Traub, P. Interaction in vitro of type III intermediate filament proteins with supercoiled plasmid DNA and modulation of eukaryotic DNA topoisomerase I and II activities. DNA AND CELL BIOLOGYnull. 2002, 21(10): 743-769, 

指导学生

现指导学生

房俊男  硕士研究生  071009-细胞生物学  

邓文强  硕士研究生  071009-细胞生物学  

龙海珍  硕士研究生  071010-生物化学与分子生物学  

温增麒  硕士研究生  071010-生物化学与分子生物学  

王岩  博士研究生  071010-生物化学与分子生物学