基本信息
李国红 男 博导 生物物理研究所
电子邮件:liguohong@sun5.ibp.ac.cn
通信地址:北京市朝阳区大屯路15号
邮政编码:100101

研究领域

染色质结构和表观遗传调控

招生信息

2012年计划招收2名硕博生
招生专业:生物化学和分子生物学


招生方向
染色质结构和基因表达调控的生物学研究

教育背景

   
学历
1991-1995:武汉大学病毒系,本科
1995-1998:北京医科大学基础医学院生物物理系,硕士研究生
1998-2003:德国马普细胞生物学研究所/海德堡大学,博士研究生
学位
1995:武汉大学病毒系,学士学位
1998:北京医科大学基础医学院生物物理系,硕士学位
2003:德国海德堡大学生物系, 博士学位

工作经历

2003-2006:美国新泽西医科大学生物化学系/霍华德.休斯医学研究院,Danny Reinberg实验室博士后
2006-2009:美国纽约大学医学院生物化学系/霍华德.休斯医学研究院,Danny Reinberg实验室博士后
2009-current:中国科学院生物物理研究所,“****”研究员,博士生导师

专利与奖励

   
专利成果
[1] 李国红, 俞洋, 包新华, 胡明丽, 王胜, 章清萍, 阮海荷. 特异性结合H1.4移码突变蛋白的单克隆抗体制备及其应用. CN113480646B, 2022-03-15.

出版信息

   
发表论文
[1] Wang, Kehui, Liu, Yuting, Yu, Zhouliang, Gu, Bo, Hu, Jie, Huang, Li, Ge, Xiao, Xu, Lingyi, Zhang, Mengyu, Zhao, Jicheng, Hu, Mingli, Le, Rongrong, Wu, Qiang, Ye, Sheng, Gao, Shaorong, Zhang, Xiaodong, Xu, RuiMing, Li, Guohong. Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle. CELL REPORTS[J]. 2021, 37(6): [2] Yu, Juan, Xiong, Chaoyang, Zhuo, Baowen, Wen, Zengqi, Shen, Jie, Liu, Cuifang, Chang, Luyuan, Wang, Kehui, Wang, Min, Wu, Chenyi, Wu, Xudong, Xu, Xueqin, Ruan, Haihe, Li, Guohong. Analysis of Local Chromatin States Reveals Gene Transcription Potential during Mouse Neural Progenitor Cell Differentiation. CELL REPORTS[J]. 2020, 32(4): http://dx.doi.org/10.1016/j.celrep.2020.107953.
[3] Xiao, Xue, Liu, Cuifang, Pei, Yingxin, Wang, YiZhou, Kong, Jingwei, Lu, Ke, Ma, Lu, Dou, ShuoXing, Wang, PengYe, Li, Guohong, Chen, Ping, Li, Wei. Histone H2A Ubiquitination Reinforces Mechanical Stability and Asymmetry at the Single-Nucleosome Level. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 142(7): 3340-3345, https://www.webofscience.com/wos/woscc/full-record/WOS:000515214000012.
[4] Zhao, Jicheng, Wang, Min, Chang, Luyuan, Yu, Juan, Song, Aoqun, Liu, Cuifang, Huang, Wenjun, Zhang, Tiantian, Wu, Xudong, Shen, Xiaohua, Zhu, Bing, Li, Guohong. RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division. NATURE CELL BIOLOGY[J]. 2020, 22(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000521529800004.
[5] 李国红. Structures and Functions of Chromatin Fibers.. Annu. Rev. Biophys. 2020, [6] Wen, Zengqi, Zhang, Liwei, Ruan, Haihe, Li, Guohong. Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(11): 5939-5952, http://dx.doi.org/10.1093/nar/gkaa360.
[7] Long, Haizhen, Zhang, Liwei, Lv, Mengjie, Wen, Zengqi, Zhang, Wenhao, Chen, Xiulan, Zhang, Peitao, Li, Tongqing, Chang, Luyuan, Jin, Caiwei, Wu, Guozhao, Wang, Xi, Yang, Fuquan, Pei, Jianfeng, Chen, Ping, Margueron, Raphael, Deng, Haiteng, Zhu, Mingzhao, Li, Guohong. H2A.Z facilitates licensing and activation of early replication origins. NATURE[J]. 2020, 577(7791): 576-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000507800800003.
[8] Wang, Liang, Hu, Mingli, Zuo, MeiQing, Zhao, Jicheng, Wu, Di, Huang, Li, Wen, Yongxin, Li, Yunfan, Chen, Ping, Bao, Xinhua, Dong, MengQiu, Li, Guohong, Li, Pilong. Rett syndrome-causing mutations compromise MeCP2-mediated liquid-liquid phase separation of chromatin. CELL RESEARCH[J]. 2020, 30(5): 393-407, http://lib.cqvip.com/Qikan/Article/Detail?id=7102094954.
[9] Xiao Xue, Dong Liping, Wang Yizhou, Wang Pengye, Li Ming, Li Guohong, Chen Ping, Li Wei. Dissection of structural dynamics of chromatin fibers by single-molecule magnetic tweezers. 生物物理学报:英文版[J]. 2018, 4(4): 222-232, http://lib.cqvip.com/Qikan/Article/Detail?id=676327040.
[10] Xiong, Chaoyang, Wen, Zengqi, Yu, Juan, Chen, Jun, Liu, ChaoPei, Zhang, Xiaodong, Chen, Ping, Xu, RuiMing, Li, Guohong. UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis- regulatory elements of genes in mouse ES cells. BMC BIOLOGY[J]. 2018, 16(1): https://doaj.org/article/db45361008fa495f92d8ffb558920954.
[11] Chen, Ping, Dong, Liping, Hu, Mingli, Wang, YiZhou, Xiao, Xue, Zhao, Zhongliang, Yan, Jie, Wang, PengYe, Reinberg, Danny, Li, Ming, Li, Wei, Li, Guohong. Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level. MOLECULAR CELL[J]. 2018, 71(2): 284-+, http://dx.doi.org/10.1016/j.molcel.2018.06.020.
[12] 李国红. H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition in mES cells.. BMC. 2018, [13] Li, Wei, Chen, Ping, Yu, Juan, Dong, Liping, Liang, Dan, Feng, Jianxun, Yan, Jie, Wang, PengYe, Li, Qing, Zhang, Zhiguo, Li, Ming, Li, Guohong. FACT Remodels the Tetranucleosomal Unit of Chromatin Fibers for Gene Transcription. MOLECULAR CELL[J]. 2016, 64(1): 120-133, http://dx.doi.org/10.1016/j.molcel.2016.08.024.
[14] 李国红. Dissecting the precise role of histone H3 K9 methylation in crosstalk with DNA maintenance methylation in mammalian cells.. Nature Communications. 2016, [15] Zhu, Ping, Li, Guohong. Structural insights of nucleosome and the 30-nm chromatin fiber. CURRENT OPINION IN STRUCTURAL BIOLOGY[J]. 2016, 36: 106-115, http://dx.doi.org/10.1016/j.sbi.2016.01.013.
[16] Xiong, Chaoyang, Wen, Zengqi, Li, Guohong. Histone Variant H3.3: A versatile H3 variant in health and in disease. SCIENCE CHINA-LIFE SCIENCESnull. 2016, 59(3): 245-256, https://www.webofscience.com/wos/woscc/full-record/WOS:000371799800004.
[17] Qianglin Fang. Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome. eLife Sciences Publications, Ltd. 2016, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201904022729925ZK.
[18] 李国红. Structural Transitions of Centromeric Chromatin Coordinate the Cell Cycle-dependent Recruitment of CENP-N.. Genes and Development. 2015, [19] Yu, Zhouliang, Zhou, Xiang, Wang, Wenjing, Deng, Wenqiang, Fang, Junnan, Hu, Hao, Wang, Zichen, Li, Shangze, Cui, Lei, Shen, Jing, Zhai, Linhui, Peng, Shengyi, Wong, Jiemin, Dong, Shuo, Yuan, Zengqiang, Ou, Guangshuo, Zhang, Xiaodong, Xu, Ping, Lou, Jizhong, Yang, Na, Chen, Ping, Xu, RuiMing, Li, Guohong. Dynamic Phosphorylation of CENP-A at Ser68 Orchestrates Its Cell-Cycle-Dependent Deposition at Centromeres. DEVELOPMENTAL CELL[J]. 2015, 32(1): 68-81, http://dx.doi.org/10.1016/j.devcel.2014.11.030.
[20] Zhao, Hongyu, Xing, Yongqiang, Liu, Guoqing, Chen, Ping, Zhao, Xiujuan, Li, Guohong, Cai, Lu. GAA triplet-repeats cause nucleosome depletion in the human genome. GENOMICS[J]. 2015, 106(2): 88-95, http://dx.doi.org/10.1016/j.ygeno.2015.06.010.
[21] Song, Feng, Chen, Ping, Sun, Dapeng, Wang, Mingzhu, Dong, Liping, Liang, Dan, Xu, RuiMing, Zhu, Ping, Li, Guohong. Cryo-EM Study of the Chromatin Fiber Reveals a Double Helix Twisted by Tetranucleosomal Units. SCIENCE[J]. 2014, 344(6182): 376-380, https://www.webofscience.com/wos/woscc/full-record/WOS:000334867800032.
[22] 李国红. Variant histone H3.3 functionally counteracts with H2A.Z to activate gene transcription.. Genes and Development. 2013, [23] Liu, ChaoPei, Xiong, Chaoyang, Wang, Mingzhu, Yu, Zhouliang, Yang, Na, Chen, Ping, Zhang, Zhiguo, Li, Guohong, Xu, RuiMing. Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2012, 19(12): 1287-+, http://www.irgrid.ac.cn/handle/1471x/756950.
[24] Li, Guohong, Reinberg, Danny. Chromatin higher-order structures and gene regulation. CURRENT OPINION IN GENETICS & DEVELOPMENTnull. 2011, 21(2): 175-186, http://dx.doi.org/10.1016/j.gde.2011.01.022.
[25] Hu, Hao, Liu, Yang, Wang, Mingzhu, Fang, Junnan, Huang, Hongda, Yang, Na, Li, Yanbo, Wang, Jianyu, Yao, Xuebiao, Shi, Yunyu, Li, Guohong, Xu, RuiMing. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. GENES & DEVELOPMENT[J]. 2011, 25(9): 901-906, http://www.irgrid.ac.cn/handle/1471x/757447.
[26] Chen, Ping, Li, Guohong. Dynamics of the higher-order structure of chromatin. PROTEIN & CELL[J]. 2010, 1(11): 967-971, https://www.webofscience.com/wos/woscc/full-record/WOS:000208511800002.
[27] Guohong Li, Raphael Margueron, Guobin Hu, David Stokes, YuhHwa Wang, Danny Reinberg. Highly Compacted Chromatin Formed in vitro Reflect the Dynamics of Transcription Activation in vivo. Molecular cell. 2010, 38(1): 41-53, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641559/.
[28] 李国红. The Program for Processing Replicative Histones H3.1 and H4: from the Cytoplasm to the Nucleus.. Nature Structural and Molecular Biology. 2010, [29] Schutte, B, Henfling, M E R, Verheyen, F K C P, Li, G, Tolstonog, G V, Ramaekers, F C S. The caspase-9 derived C-terminal fragment of cytokeratin 18 modulates topoisomerase action. INTERNATIONAL JOURNAL OF ONCOLOGY[J]. 2009, 35(3): 625-630, https://www.webofscience.com/wos/woscc/full-record/WOS:000268736400018.
[30] Margueron, Raphael, Li, Guohong, Sarma, Kavitha, Blais, Alexandre, Zavadil, Jiri, Woodcock, Christopher L, Dyniacht, Brian D, Reinberg, Danny. Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms. MOLECULAR CELL[J]. 2008, 32(4): 503-518, http://dx.doi.org/10.1016/j.molcel.2008.11.004.
[31] Trojer, Patrick, Li, Guohong, Sims, Robert J, III, Vaquero, Alejandro, Kalakonda, Nagesh, Boccuni, Piernicola, Lee, Donghoon, ErdjumentBromage, Hediye, Tempst, Paul, Nimer, Stephen D, Wang, YuhHwa, Reinberg, Danny. L3MBTL1, a histone-methylation-dependent chromatin lock. CELL[J]. 2007, 129(5): 915-928, http://dx.doi.org/10.1016/j.cell.2007.03.048.
[32] Pavri, Rushad, Zhu, Bing, Li, Guohong, Trojer, Patrick, Mandal, Subhrangsu, Shilatifard, Ali, Reinberg, Danny. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. CELL[J]. 2006, 125(4): 703-717, http://dx.doi.org/10.1016/j.cell.2006.04.029.
[33] Sims, Robert J, III, Trojer, Patrick, Li, Guohong, Reinberg, Danny. Methods to identify and functionally analyze factors that specifically recognize histone lysine methylation. METHODS[J]. 2006, 40(4): 331-338, http://dx.doi.org/10.1016/j.ymeth.2006.07.031.
[34] Tolstonog, GV, Li, GH, Shoeman, RL, Traub, P. Interaction in vitro of type III intermediate filament proteins with higher order structures of single-stranded DNA, particularly with G-quadruplex DNA. DNA AND CELL BIOLOGYnull. 2005, 24(2): 85-110, https://www.webofscience.com/wos/woscc/full-record/WOS:000226839600003.
[35] Li, GH, Tolstonog, GV, Sabasch, M, Traub, P. Type III intermediate filament proteins interact with four-way junction DNA and facilitate its cleavage by the junction-resolving enzyme T7 endonuclease I. DNA AND CELL BIOLOGYnull. 2003, 22(4): 261-291, https://www.webofscience.com/wos/woscc/full-record/WOS:000183354800006.
[36] Li, GH, Tolstonog, GV, Traub, P. Interaction in vitro of type III intermediate filament proteins with Z-DNA and B-Z-DNA junctions. DNA AND CELL BIOLOGYnull. 2003, 22(3): 141-169, https://www.webofscience.com/wos/woscc/full-record/WOS:000182803700001.
[37] Li, GH, Tolstonog, GV, Traub, P. Interaction in vitro of type III intermediate filament proteins with triplex DNA. DNA AND CELL BIOLOGYnull. 2002, 21(3): 163-188, [38] Li, GH, Tolstonog, GV, Sabasch, M, Traub, P. Interaction in vitro of type III intermediate filament proteins with supercoiled plasmid DNA and modulation of eukaryotic DNA topoisomerase I and II activities. DNA AND CELL BIOLOGYnull. 2002, 21(10): 743-769, 

指导学生

现指导学生

房俊男  硕士研究生  071009-细胞生物学  

邓文强  硕士研究生  071009-细胞生物学  

龙海珍  硕士研究生  071010-生物化学与分子生物学  

温增麒  硕士研究生  071010-生物化学与分子生物学  

王岩  博士研究生  071010-生物化学与分子生物学