071021-生物信息学

系统生物学，阿尔茨海默症，干细胞，大数据

1998-08--2003-05   Kansas State University   生物化学博士
1987-09--1991-06   华中理工大学   工学学士

   

2003-08~2008-06,美国德拉华大学/加州大学戴维斯分校, 博士后/研究组主管
1991-07~1998-06,军事医学科学院, 助理研究员

基因组学前沿
神经系统疾病和网络分析
人类基因组学研究-进展与应用

   

[1] 雷红星. 一种预判重症新冠肺炎（COVID-19）的标志物及其产品和用途. CN: CN112795646A, 2021-05-14.

   

[1] Hongxing Lei, Bumsuk Hahm. Hypoxia and Activation of Neutrophil Degranulation-Related Genes in the Peripheral Blood of COVID-19 Patients. VIRUSES. 2024, 第 1 作者16(2): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10891603/.
[2] Lei, Hongxing. Quantitative and Longitudinal Assessment of Systemic Innate Immunity in Health and Disease Using a 2D Gene Model. BIOMEDICINES[J]. 2024, 第 1 作者  通讯作者  12(5): http://dx.doi.org/10.3390/biomedicines12050969.
[3] Hongxing Lei. A two-gene marker for the two-tiered innate immune response in COVID-19 patients. PLOS ONE[J]. 2022, 第 1 作者
[4] Hongxing Lei. A two-gene marker for the two-tiered innate immune response in COVID-19 patients. PLoS ONE[J]. 2022, 第 1 作者
[5] Lei, Hongxing, Wang, Chi, Wang, Yunlai, Wang, Chengbin. Single-cell RNA-Seq revealed profound immune alteration in the peripheral blood of patients with bacterial infection. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES[J]. 2021, 第 1 作者  通讯作者  103: 527-535, https://doaj.org/article/017bfaf40f234d99874a7d26e880786e.
[6] Lei, Hongxing, Xu, Xiaoyue, Wang, Chi, Xue, Dandan, Wang, Chengbin, Chen, Jiankui. A host-based two-gene model for the identification of bacterial infection in general clinical settings. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES[J]. 2021, 第 1 作者  通讯作者  105: 662-667, https://doaj.org/article/2455f26fbb76418ca5c8be192043b06d.
[7] Lei, Hongxing. A single transcript for the prognosis of disease severity in COVID-19 patients. SCIENTIFIC REPORTS[J]. 2021, 第 1 作者  通讯作者  11(1): http://dx.doi.org/10.1038/s41598-021-91754-7.
[8] Lei, Hongxing, Wang, Chi, Wang, Yunlai, Wang, Chengbin. Single-cell RNA-Seq revealed profound immune alteration in the peripheral blood of patients with bacterial infection. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES[J]. 2021, 第 11 作者103: 527-535, http://dx.doi.org/10.1016/j.ijid.2020.11.205.
[9] Lei, Hongxing, Xu, Xiaoyue, Wang, Chi, Xue, Dandan, Wang, Chengbin, Chen, Jiankui. A host-based two-gene model for the identification of bacterial infection in general clinical settings. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES[J]. 2021, 第 11 作者105: 662-667, http://dx.doi.org/10.1016/j.ijid.2021.02.112.
[10] Hongxing Lei. A single transcript for the prognosis of disease severity in COVID-19 patients. SCIENTIFIC REPORTS[J]. 2021, 第 11 作者11(1): http://dx.doi.org/10.1038/s41598-021-91754-7.
[11] Hongzhu Qu, Hongxing Lei, Xiangdong Fang. Big Data and the Brain: Peeking at the Future. 基因组蛋白质组与生物信息学报:英文版[J]. 2019, 第 2 作者  通讯作者  17(4): 333-336, http://dx.doi.org/10.1016/j.gpb.2019.11.003.
[12] Peng, Xing, Zhang, Zhengshan, Ye, Dongqing, Xing, Peiqi, Zou, Zhengxing, Lei, Hongxing, Duan, Lian. Gene dysregulation in peripheral blood of moyamoya disease and comparison with other vascular disorders. PLOS ONE[J]. 2019, 第 6 作者  通讯作者  14(9): https://doaj.org/article/b19d04c07da449c29997c13de3f8f3ce.
[13] Guo, Zongjun, Peng, Xing, Li, HuiYun, Wang, Yunlai, Qian, Ying, Wang, Zhihong, Ye, Dongqing, Ji, Xiaoyun, Wang, Zhixin, Wang, Yanjiang, Chen, Dongwan, Lei, Hongxing. Evaluation of Peripheral Immune Dysregulation in Alzheimer's Disease and Vascular Dementia. JOURNAL OF ALZHEIMERS DISEASE[J]. 2019, 第 12 作者  通讯作者  71(4): 1175-1186, http://dx.doi.org/10.3233/JAD-190666.
[14] Hongzhu Qu, Hongxing Lei, Xiangdong Fang. Big Data and the Brain: Peeking at the Future. Genomics, Proteomics & Bioinformatics[J]. 2019, 第 11 作者17(4): 333-336, http://lib.cqvip.com/Qikan/Article/Detail?id=7101029389.
[15] Xing Peng, Zhengshan Zhang, Dongqing Ye, Peiqi Xing, Zhengxing Zou, Hongxing Lei, Lian Duan. Gene dysregulation in peripheral blood of moyamoya disease and comparison with other vascular disorders.. PLoS ONE[J]. 2019, 第 11 作者14(9): https://doaj.org/article/b19d04c07da449c29997c13de3f8f3ce.
[16] Guo, Zongjun, Peng, Xing, Li, HuiYun, Wang, Yunlai, Qian, Ying, Wang, Zhihong, Ye, Dongqing, Ji, Xiaoyun, Wang, Zhixin, Wang, Yanjiang, Chen, Dongwan, Lei, Hongxing. Evaluation of Peripheral Immune Dysregulation in Alzheimer's Disease and Vascular Dementia. JOURNAL OF ALZHEIMERS DISEASE[J]. 2019, 第 11 作者71(4): 1175-1186, 
[17] Wang, Yanqing, Song, Fuhai, Zhu, Junwei, Zhang, Sisi, Yang, Yadong, Chen, Tingting, Tang, Bixia, Dong, Lili, Ding, Nan, Zhang, Qian, Bai, Zhouxian, Dong, Xunong, Chen, Huanxin, Sun, Mingyuan, Zhai, Shuang, Sun, Yubin, Yu, Lei, Lan, Li, Xiao, Jingfa, Fang, Xiangdong, Lei, Hongxing, Zhang, Zhang, Zhao, Wenming. GSA: Genome Sequence Archive. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2017, 第 21 作者  通讯作者  15(1): 14-18, http://lib.cqvip.com/Qikan/Article/Detail?id=671499521.
[18] Song, Fuhai, Qian, Ying, Peng, Xing, Li, Xiuhui, Xing, Peiqi, Ye, Dongqing, Lei, Hongxing. The frontline of immune response in peripheral blood. PLOS ONE[J]. 2017, 第 7 作者  通讯作者  12(8): https://doaj.org/article/1ec1e3ded4c94223945e243b85cd2b88.
[19] Wang, Yanqing, Song, Fuhai, Zhu, Junwei, Zhang, Sisi, Yang, Yadong, Chen, Tingting, Tang, Bixia, Dong, Lili, Ding, Nan, Zhang, Qian, Bai, Zhouxian, Dong, Xunong, Chen, Huanxin, Sun, Mingyuan, Zhai, Shuang, Sun, Yubin, Yu, Lei, Lan, Li, Xiao, Jingfa, Fang, Xiangdong, Lei, Hongxing, Zhang, Zhang, Zhao, Wenming. GSA: Genome Sequence Archive. GENOMICS PROTEOMICS & BIOINFORMATICS. 2017, 第 11 作者15(1): 14-18, http://lib.cqvip.com/Qikan/Article/Detail?id=671499521.
[20] Song, Fuhai, Qian, Ying, Peng, Xing, Li, Xiuhui, Xing, Peiqi, Ye, Dongqing, Lei, Hongxing. The frontline of immune response in peripheral blood. PLOS ONE[J]. 2017, 第 11 作者12(8): https://doaj.org/article/1ec1e3ded4c94223945e243b85cd2b88.
[21] Song, Fuhai, Qian, Ying, Peng, Xing, Han, Guangchun, Wang, Jiajia, Bai, Zhouxian, Crack, Peter J, Lei, Hongxing. Perturbation of the transcriptome: implications of the innate immune system in Alzheimer's disease. CURRENTOPINIONINPHARMACOLOGY[J]. 2016, 第 8 作者  通讯作者  26: 47-53, http://dx.doi.org/10.1016/j.coph.2015.09.015.
[22] Bai, Zhouxian, Han, Guangchun, Xie, Bin, Wang, Jiajia, Song, Fuhai, Peng, Xing, Lei, Hongxing. AlzBase: an Integrative Database for Gene Dysregulation in Alzheimer's Disease. MOLECULAR NEUROBIOLOGY[J]. 2016, 第 7 作者  通讯作者  53(1): 310-319, http://dx.doi.org/10.1007/s12035-014-9011-3.
[23] Song, Fuhai, Qian, Ying, Peng, Xing, Han, Guangchun, Wang, Jiajia, Bai, Zhouxian, Crack, Peter J, Lei, Hongxing. Perturbation of the transcriptome: implications of the innate immune system in Alzheimer's disease. CURRENT OPINION IN PHARMACOLOGY[J]. 2016, 第 11 作者26: 47-53, http://dx.doi.org/10.1016/j.coph.2015.09.015.
[24] Bai, Zhouxian, Han, Guangchun, Xie, Bin, Wang, Jiajia, Song, Fuhai, Peng, Xing, Lei, Hongxing. AlzBase: an Integrative Database for Gene Dysregulation in Alzheimer's Disease. MOLECULAR NEUROBIOLOGY[J]. 2016, 第 11 作者53(1): 310-319, http://dx.doi.org/10.1007/s12035-014-9011-3.
[25] Song, Fuhai, Han, Guangchun, Bai, Zhouxian, Peng, Xing, Wang, Jiajia, Lei, Hongxing, Hurley, MJ. Alzheimer's Disease: Genomics and Beyond. OMIC STUDIES OF NEURODEGENERATIVE DISEASE, PT A. 2015, 第 6 作者  通讯作者  121: 1-24, https://www.webofscience.com/wos/woscc/full-record/WOS:000405619300002.
[26] Song, Fuhai, Han, Guangchun, Bai, Zhouxian, Peng, Xing, Wang, Jiajia, Lei, Hongxing, Hurley, MJ. Alzheimer's Disease: Genomics and Beyond. OMIC STUDIES OF NEURODEGENERATIVE DISEASE, PT A. 2015, 第 11 作者121: 1-24, https://www.webofscience.com/wos/woscc/full-record/WOS:000405619300002.
[27] Wang, Jiajia, Feng, Xuemei, Bai, Zhouxian, Jin, LeeWay, Duan, Yong, Lei, Hongxing. Chromosome 19p in Alzheimer's Disease: When Genome Meets Transcriptome. JOURNAL OF ALZHEIMERS DISEASE[J]. 2014, 第 6 作者  通讯作者  38(2): 245-250, https://www.webofscience.com/wos/woscc/full-record/WOS:000327182800002.
[28] Lei, Hongxing, Sun, Jiya, Baldwin, Enoch P, Segal, David J, Duan, Yong, Donev, R. Conformational Elasticity can Facilitate TALE DNA Recognition. ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY, VOL 94. 2014, 第 1 作者  通讯作者  94: 347-364, https://www.webofscience.com/wos/woscc/full-record/WOS:000334129200009.
[29] Sun, Jiya, Song, Fuhai, Wang, Jiajia, Han, Guangchun, Bai, Zhouxian, Xie, Bin, Feng, Xuemei, Jia, Jianping, Duan, Yong, Lei, Hongxing. Hidden Risk Genes with High-Order Intragenic Epistasis in Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE[J]. 2014, 第 10 作者  通讯作者  41(4): 1039-1056, http://dx.doi.org/10.3233/JAD-140054.
[30] Wang, Jiajia, Feng, Xuemei, Bai, Zhouxian, Jin, LeeWay, Duan, Yong, Lei, Hongxing. Chromosome 19p in Alzheimer's Disease: When Genome Meets Transcriptome. JOURNAL OF ALZHEIMERS DISEASE[J]. 2014, 第 11 作者38(2): 245-250, https://www.webofscience.com/wos/woscc/full-record/WOS:000327182800002.
[31] Lei, Hongxing, Sun, Jiya, Baldwin, Enoch P, Segal, David J, Duan, Yong, Donev, R. Conformational Elasticity can Facilitate TALE DNA Recognition. ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY, VOL 94. 2014, 第 11 作者94: 347-364, https://www.webofscience.com/wos/woscc/full-record/WOS:000334129200009.
[32] Sun, Jiya, Song, Fuhai, Wang, Jiajia, Han, Guangchun, Bai, Zhouxian, Xie, Bin, Feng, Xuemei, Jia, Jianping, Duan, Yong, Lei, Hongxing. Hidden Risk Genes with High-Order Intragenic Epistasis in Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE[J]. 2014, 第 11 作者41(4): 1039-1056, http://dx.doi.org/10.3233/JAD-140054.
[33] Han, Guangchun, Wang, Jiajia, Zeng, Fan, Feng, Xuemei, Yu, Jun, Cao, HongYuan, Yi, Xu, Zhou, Huadong, Jin, LeeWay, Duan, Yong, Wang, YanJiang, Lei, Hongxing. Characteristic Transformation of Blood Transcriptome in Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE[J]. 2013, 第 12 作者  通讯作者  35(2): 373-386, https://www.webofscience.com/wos/woscc/full-record/WOS:000317914100015.
[34] Lei Hongxing. The functional network of human divergently paired genes (DPGs). PLoS One. 2013, 第 1 作者  通讯作者  
[35] Sun Jiya, Pan Yuyun, Feng Xuemei, Zhang Huijuan, Duan Yong, Lei Hongxing. iBIG: An Integrative Network Tool for Supporting Human Disease Mechanism Studies. GENOMICS, PROTEOMICS & BIOINFORMATICS[J]. 2013, 第 6 作者11(3): 166-171, http://dx.doi.org/10.1016/j.gpb.2012.08.007.
[36] Han, Guangchun, Wang, Jiajia, Zeng, Fan, Feng, Xuemei, Yu, Jun, Cao, HongYuan, Yi, Xu, Zhou, Huadong, Jin, LeeWay, Duan, Yong, Wang, YanJiang, Lei, Hongxing. Characteristic Transformation of Blood Transcriptome in Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE[J]. 2013, 第 11 作者35(2): 373-386, https://www.webofscience.com/wos/woscc/full-record/WOS:000317914100015.
[37] Lei Hongxing. The functional network of human divergently paired genes (DPGs). PLoS One. 2013, 第 11 作者
[38] Sun Jiya, Pan Yuyun, Feng Xuemei, Zhang Huijuan, Duan Yong, Lei Hongxing. iBIG: An Integrative Network Tool for Supporting Human Disease Mechanism Studies. Genomics, Proteomics & Bioinformatics[J]. 2013, 第 6 作者11(3): 166-171, http://dx.doi.org/10.1016/j.gpb.2012.08.007.
[39] Liang, Dapeng, Han, Guangchun, Feng, Xuemei, Sun, Jiya, Duan, Yong, Lei, Hongxing. Concerted Perturbation Observed in a Hub Network in Alzheimer's Disease. PLOS ONE[J]. 2012, 第 6 作者7(7): https://www.webofscience.com/wos/woscc/full-record/WOS:000306466100037.
[40] Sun, Jiya, Feng, Xuemei, Liang, Dapeng, Duan, Yong, Lei, Hongxing. Down-Regulation of Energy Metabolism in Alzheimer's Disease is a Protective Response of Neurons to the Microenvironment. JOURNAL OF ALZHEIMERS DISEASE[J]. 2012, 第 5 作者  通讯作者  28(2): 389-402, https://www.webofscience.com/wos/woscc/full-record/WOS:000300008800013.
[41] Liang, Dapeng, Han, Guangchun, Feng, Xuemei, Sun, Jiya, Duan, Yong, Lei, Hongxing. Concerted Perturbation Observed in a Hub Network in Alzheimer's Disease. PLOS ONE[J]. 2012, 第 6 作者7(7): https://www.webofscience.com/wos/woscc/full-record/WOS:000306466100037.
[42] Sun, Jiya, Feng, Xuemei, Liang, Dapeng, Duan, Yong, Lei, Hongxing. Down-Regulation of Energy Metabolism in Alzheimer's Disease is a Protective Response of Neurons to the Microenvironment. JOURNAL OF ALZHEIMERS DISEASE[J]. 2012, 第 11 作者28(2): 389-402, https://www.webofscience.com/wos/woscc/full-record/WOS:000300008800013.

   

（ 1 ） 细胞命运维持与转化的表观遗传调控作用与机制研究, 参与, 国家级, 2014-01--2018-12
（ 2 ） 组学大数据中心和知识库构建与服务技术, 参与, 国家级, 2015-01--2017-12

已指导学生

孙继亚  02  19183  

裴玉超  02  19187  

潘玉云  02  19187  

苏尧  01  19187  

梁大鹏  01  19187  

孙继亚  01  19187  

谢彬  01  19187  

韩光春  01  19187  

汪嘉葭  01  19187  

白周现  01  67687  

现指导学生

宋福海  01  67687  

李秀辉  02  63228  

邢培琪  02  67687  

彭星  01  67687  

陈传远   02  67687  

钱颖  01  67687