蒋岚  男  博导  中国科学院北京基因组研究所(国家生物信息中心)
电子邮件: jiangl@big.ac.cn
通信地址: 北辰西路1号院104号楼
邮政编码:

研究领域

基因组学;表观遗传学

招生信息

   
招生专业
0710Z1-基因组学
0710J3-生物信息学
招生方向
基因组学;表观遗传学

教育背景

2007-09--2013-07   中国科学院大学   博士学位
2001-09--2005-07   武汉大学   学士学位
学士

2001/09-2005/07, 武汉大学,学士

博士

2007/09-2013/07, 中国科学院大学,基因组学,博士

工作经历

1. 2018/11-至今,中国科学院北京基因组研究所,中国科学院基因组科学与信息重点实验室,研究员

2. 2013/11-2018/11, 波士顿儿童医院&哈佛医学院,遗传系,博士后,

3. 2005/07-2007/07, 华大基因股份有限公司, 生物信息分析部,工程师

教授课程

分子遗传学和表观遗传学
基因组技术与健康大数据

专利与奖励

   
奖励信息
(1) 吴瑞奖学金, 特等奖, 国家级, 2013
(2) 院长特别奖学金, 特等奖, 院级, 2013

出版信息

   
发表文章
[1] Gao, Xueliang, Wang, Yubao, Ribeiro, Caroline F, Manokaran, Cherubin, Chang, Hyeyoun, Von, Thanh, Rodrigues, Silvia, Cizmecioglu, Onur, Jia, Shidong, Korpal, Manav, Korn, Joshua M, Wang, Zhigang, Schmit, Fabienne, Jiang, Lan, Pagliarini, Raymond, Yang, Yi, Sethi, Isha, Signoretti, Sabina, Yuan, Guo-Cheng, Loda, Massimo, Zhao, Jean J, Roberts, Thomas M. Blocking PI3K p110β Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer. MOLECULAR CANCER RESEARCH[J]. 2022, 20(5): 673-685, https://aacrjournals.org/mcr/article-abstract/20/5/673/694646/Blocking-PI3K-p110-Attenuates-Development-of-PTEN?redirectedFrom=fulltext.
[2] Hang, Xinxin, He, Shiqi, Dong, Zaizai, Li, Yun, Huang, Zheng, Zhang, Yanruo, Sun, Hong, Lin, Long, Li, Hu, Wang, Yang, Liu, Bing, Wu, Nan, Ren, Tianling, Fan, Yubo, Lou, Jizhong, Yang, Ruiguo, Jiang, Lan, Chang, Lingqian. High-throughput DNA tensioner platform for interrogating mechanical heterogeneity of single living cell. Small[J]. 2022, 18(12): https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.202106196.
[3] Joyce, Cailin E, Saadatpour, Assieh, RuizGutierrez, Melisa, Bolukbasi, Ozge Vargel, Jiang, Lan, Thomas, Dolly D, Young, Sarah, Hofmann, Inga, Sieff, Colin A, Myers, Kasiani C, Whangbo, Jennifer, Libermann, Towia A, Nusbaum, Chad, Yuan, GuoCheng, Shimamura, Akiko, Novina, Carl D. TGF-beta signaling underlies hematopoietic dysfunction and bone marrow failure in Shwachman-Diamond syndrome. JOURNAL OF CLINICAL INVESTIGATION[J]. 2019, 129(9): 3821-3826, https://www.webofscience.com/wos/woscc/full-record/WOS:000484368600036.
[4] Li, Juan, Jiang, Lan, Wu, ChungI, Lu, Xuemei, Fang, Shu, Ting, ChauTi. Small Segmental Duplications in DrosophilaHigh Rate of Emergence and Elimination. GENOME BIOLOGY AND EVOLUTION[J]. 2019, 11(2): 486-496, https://www.webofscience.com/wos/woscc/full-record/WOS:000467953500012.
[5] Jiang, Lan, Tsoucas, Daphne, Yuan, GuoCheng. Assessing Inequality in Transcriptomic Data. CELL SYSTEMS[J]. 2018, 6(2): 149-150, http://dx.doi.org/10.1016/j.cels.2018.02.007.
[6] Matoba, Shogo, Wang, Huihan, Jiang, Lan, Lu, Falong, Iwabuchi, Kumiko A, Wu, Xiaoji, Inoue, Kimiko, Yang, Lin, Press, William, Lee, Jeannie T, Ogura, Atsuo, Shen, Li, Zhang, Yi. Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development. CELL STEM CELL[J]. 2018, 23(3): 343-+, http://dx.doi.org/10.1016/j.stem.2018.06.008.
[7] Djekidel, Mohamed Nadhir, Inoue, Azusa, Matoba, Shogo, Suzuki, Tsukasa, Zhang, Chunxia, Lu, Falong, Jiang, Lan, Zhang, Yi. Reprogramming of Chromatin Accessibility in Somatic Cell Nuclear Transfer Is DNA Replication Independent. CELL REPORTS[J]. 2018, 23(7): 1939-1947, http://dx.doi.org/10.1016/j.celrep.2018.04.036.
[8] Inoue, Azusa, Jiang, Lan, Lu, Falong, Suzuki, Tsukasa, Zhang, Yi. Maternal H3K27me3 controls DNA methylation-independent imprinting. NATURE[J]. 2017, 547(7664): 419-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000406358300028.
[9] Chen, Renchao, Wu, Xiaoji, Jiang, Lan, Zhang, Yi. Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity. CELL REPORTS[J]. 2017, 18(13): 3227-3241, http://dx.doi.org/10.1016/j.celrep.2017.03.004.
[10] Inoue, Azusa, Jiang, Lan, Lu, Falong, Zhang, Yi. Genomic imprinting of Xist by maternal H3K27me3. GENES & DEVELOPMENT[J]. 2017, 31(19): 1927-1932, https://www.webofscience.com/wos/woscc/full-record/WOS:000414054000001.
[11] Wang, Kaile, Ma, Qin, Jiang, Lan, Lai, Shujuan, Lu, Xuemei, Hou, Yali, Wu, ChungI, Ruan, Jue. Ultra-precise detection of mutations by droplet-based amplification of circularized DNA (vol 17, 214, 2016). BMC GENOMICS[J]. 2016, 17: https://www.webofscience.com/wos/woscc/full-record/WOS:000377562700001.
[12] Jiang, Lan, Chen, Huidong, Pinello, Luca, Yuan, GuoCheng. GiniClust: detecting rare cell types from single-cell gene expression data with Gini index. GENOME BIOLOGY[J]. 2016, 17: https://www.webofscience.com/wos/woscc/full-record/WOS:000378902100001.
[13] Cailin Joyce PhD, Assieh Saadatpour PhD, Lan Jiang PhD, Melisa RuizGutierrez MDPhD, Ozge Vargel Bolukbasi PhD, Inga Hofmann MD, Colin A Sieff MBBCh, Chad Nusbaum PhD, Akiko Shimamura MD PhD, GuoCheng Yuan PhD, Carl D Novina MDPhD. Single Cell Transcriptional Profiling Reveals Activation of TNF-Alpha Signaling in Hematopoietic Stem and Progenitor Cells from Shwachman-Diamond Syndrome Patients. Blood. 2016, 128(22): 335-335, [14] Kim, TaeHee, Saadatpour, Assieh, Guo, Guoji, Saxena, Madhurima, Cavazza, Alessia, Desai, Niyati, Jadhav, Unmesh, Jiang, Lan, Rivera, Miguel N, Orkin, Stuart H, Yuan, GuoCheng, Shivdasani, Ramesh A. Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. CELL REPORTS[J]. 2016, 16(8): 2053-2060, http://dx.doi.org/10.1016/j.celrep.2016.07.056.
[15] Lu, Falong, Liu, Yuting, Jiang, Lan, Yamaguchi, Shinpei, Zhang, Yi. Role of Tet proteins in enhancer activity and telomere elongation. GENES & DEVELOPMENT[J]. 2014, 28(19): 2103-2119, https://www.webofscience.com/wos/woscc/full-record/WOS:000342888200004.
[16] Chong, Zechen, Zhai, Weiwei, Li, Chunyan, Gao, Min, Gong, Qiang, Ruan, Jue, Li, Juan, Jiang, Lan, Lv, Xuemei, Hungate, Eric, Wu, ChungI. The Evolution of Small Insertions and Deletions in the Coding Genes of Drosophila melanogaster. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2013, 30(12): 2699-2708, https://www.webofscience.com/wos/woscc/full-record/WOS:000327793000015.
[17] Ruan, Jue, Jiang, Lan, Chong, Zechen, Gong, Qiang, Li, Heng, Li, Chunyan, Tao, Yong, Zheng, Caihong, Zhai, Weiwei, Turissini, David, Cannon, Charles H, Lu, Xuemei, Wu, ChungI. Pseudo-Sanger sequencing: massively parallel production of long and near error-free reads using NGS technology. BMC GENOMICS[J]. 2013, 14(711): http://ir.xtbg.org.cn/handle/353005/4786.
[18] Jiang, Lan, Zhang, Jing, Wang, JingJing, Wang, Lu, Zhang, Li, Li, Guoqiang, Yang, Xiaodan, Ma, Xin, Sun, Xin, Cai, Jun, Zhang, Jun, Huang, Xingxu, Yu, Miao, Wang, Xuegeng, Liu, Feng, Wu, ChungI, He, Chuan, Zhang, Bo, Ci, Weimin, Liu, Jiang. Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos. CELL[J]. 2013, 153(4): 773-784, http://dx.doi.org/10.1016/j.cell.2013.04.041.
[19] Tao, Yong, Ruan, Jue, Yeh, ShiouHwei, Lu, Xuemei, Wang, Yu, Zhai, Weiwei, Cai, Jun, Ling, Shaoping, Gong, Qiang, Chong, Zecheng, Qu, Zhengzhong, Li, Qianqian, Liu, Jiang, Yang, Jin, Zheng, Caihong, Zeng, Changqing, Wang, HurngYi, Zhang, Jing, Wang, ShengHan, Hao, Lingtong, Dong, Lili, Li, Wenjie, Sun, Min, Zou, Wei, Yu, Caixia, Li, Chaohua, Liu, Guojing, Jiang, Lan, Xu, Jin, Huang, Huanwei, Li, Chunyan, Mi, Shuangli, Zhang, Bing, Chen, Baoxian, Zhao, Wenming, Hu, Songnian, Zhuang, ShiMei, Shen, Yang, Shi, Suhua, Brown, Christopher, White, Kevin P, Chen, DingShinn, Chen, PeiJer, Wu, ChungI. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2011, 108(29): 12042-12047, http://dx.doi.org/10.1073/pnas.1108715108.
[20] Lei Wang, Lan Jiang, Songnian Hu, Yejun Wang. Characterization of Evolutionarily Conserved MicroRNAs in Amphioxus. 基因组蛋白质组与生物信息学报:英文版[J]. 2010, 10-21, http://lib.cqvip.com/Qikan/Article/Detail?id=33671406.
[21] Xia, Qingyou, Guo, Yiran, Zhang, Ze, Li, Dong, Xuan, Zhaoling, Li, Zhuo, Dai, Fangyin, Li, Yingrui, Cheng, Daojun, Li, Ruiqiang, Cheng, Tingcai, Jiang, Tao, Becquet, Celine, Xu, Xun, Liu, Chun, Zha, Xingfu, Fan, Wei, Lin, Ying, Shen, Yihong, Jiang, Lan, Jensen, Jeffrey, Hellmann, Ines, Tang, Si, Zhao, Ping, Xu, Hanfu, Yu, Chang, Zhang, Guojie, Li, Jun, Cao, Jianjun, Liu, Shiping, He, Ningjia, Zhou, Yan, Liu, Hui, Zhao, Jing, Ye, Chen, Du, Zhouhe, Pan, Guoqing, Zhao, Aichun, Shao, Haojing, Zeng, Wei, Wu, Ping, Li, Chunfeng, Pan, Minhui, Li, Jingjing, Yin, Xuyang, Li, Dawei, Wang, Juan, Zheng, Huisong, Wang, Wen, Zhang, Xiuqing, Li, Songgang, Yang, Huanming, Lu, Cheng, Nielsen, Rasmus, Zhou, Zeyang, Wang, Jian, Xiang, Zhonghuai, Wang, Jun. Complete Resequencing of 40 Genomes Reveals Domestication Events and Genes in Silkworm (Bombyx). SCIENCE[J]. 2009, 326(5951): 433-436, http://dx.doi.org/10.1126/science.1176620.
发表论著
(1) Computational methods for single-cell data analysis (Chapter 5: Rare Cell Type Detection), Humana Press, 2019-02, 第 1 作者

科研活动

科研项目:

( 1 ) 人才项目, 主持, 国家级, 2019-01--2021-12

参与会议
(1)母源组蛋白修饰介导的新型印记基因   首届“共铸新生命”论坛—胚胎反复着床失败   2019-12-28
(2)Maternal H3K27me3 controls DNA methylation independent   第二届 细胞生物信息学研讨会   2019-12-11
(3)印记基因:经典和新篇   第四届“红土”生命科学前沿青年论坛   2019-10-21
(4)Maternal H3K27me3 controls DNA methylation-independent imprinting   2019 吴瑞青年论坛   2019-07-18
(5)Detecting rare cell types from single-cell gene expression data   2017-02-20

指导学生

已指导学生

赵婷  硕士研究生  071010-生物化学与分子生物学  

现指导学生

李芸  博士研究生  0710Z1-基因组学  

虞程伟  博士研究生  0710Z1-基因组学  

孙少省  硕士研究生  0710J3-生物信息学  

李子仪  硕士研究生  0710J3-生物信息学  

高晓玥  硕士研究生  0710J3-生物信息学  

黄正  博士研究生  0710J3-生物信息学  

刘蒙蒙  博士研究生  071007-遗传学  

徐矗  博士研究生  0710Z1-基因组学  

元杨  硕士研究生  0710Z1-基因组学  

王弃非  硕士研究生  0710Z1-基因组学  

陈甚之  硕士研究生  0710J3-生物信息学  

艾娜  博士研究生  0710J3-生物信息学  

徐扬清  硕士研究生  0710J3-生物信息学