071005-微生物学
071009-细胞生物学

病毒学，免疫学
抗病毒药物筛选

1997-08--2003-08   美国德克萨斯大学   博士
1994-09--1997-07   北京大学   硕士
1990-09--1994-07   四川大学   学士

-- 研究生

-- 博士

   

2016-01~现在, 中国科学院, 特聘研究员（特聘核心骨干）
2013-01~现在, 上海科技大学, 特聘教授
2007-01~现在, 中国科学院上海巴斯德研究所, 研究员，研究组长，所长助理
2003-09~2006-12,美国Scripps研究院, 博士后，研究助理

2011-01-01-今,中国微生物学学会病毒学专业委员会, 委员
2010-01-01-今,中华医学会医学病毒学分会, 委员
2007-01-01-今,上海微生物学会, 理事

病毒学

   

（1） 法国驻华使馆“2015 Emergences”奖, 其他, 2015
（2） 中科院“优秀研究生指导教师”奖, 部委级, 2014
（3） 国务院政府特殊津贴专家, , 国家级, 2013
（4） 中科院上海分院杰出青年科技创新人才提名奖, , 院级, 2012
（5） 中科院“朱李月华”优秀教师奖, , 院级, 2012
（6） 优秀青年人才, , 院级, 2010
（7） 法国人才创新奖, , 其他, 2009
（8） ****, , 院级, 2008

（ 1 ） 9,10-蒽醌类化合物的应用, 发明, 2012, 第 2 作者, 专利号: ZL 2008 1 0203112.1
（ 2 ） 黄酮类化合物或含其的植物提取物的应用, 发明, 2009, 第 2 作者, 专利号: 200910150374.0
（ 3 ） Use of 9,10-Anthraquinone Compounds, 发明, 2009, 第 2 作者, 专利号: PCT/CN2009/075075
（ 4 ） 一种感染能力增强的重组嵌合型丙型肝炎病毒株。, 发明, 2013, 第 1 作者, 专利号: 201310172776.7
（ 5 ） 构建基因2a型丙型肝炎病毒临床分离株细胞培养模型的方法。 , 发明, 2013, 第 1 作者, 专利号: 201310479702.8
（ 6 ） 一种丙型肝炎病毒重组蛋白的制备及其应用, 发明, 2014, 第 2 作者, 专利号: 201410367643X
（ 7 ） 可用于抗病毒药物筛选的埃博拉病毒复制子模型及其应用, 发明, 2015, 第 1 作者, 专利号: 201510390783.3
（ 8 ） 一种丙型肝炎病毒三价亚单位疫苗的制备及应用, 发明, 2016, 第 1 作者, 专利号: 201610595121.4
（ 9 ） 一种展示丙型肝炎病毒包膜蛋白E2 的纳米颗粒的制备及应用, 发明, 2016, 第 2 作者, 专利号: 201610595142.6

   

[1] hLife. 2024,   通讯作者  
[2] Emerging Microbes & Infections. 2024,   通讯作者  
[3] Emerging Microbes & Infections. 2024,   通讯作者  
[4] Journal of Medical Virology. 2023,   通讯作者  
[5] Yifan Xing, Ran Chen, Feng Li, Bin Xu, Lin Han, Chaolun Liu, Yimin Tong, Yaming Jiu, Jin Zhong, GuoChun Zhou. Discovery of a fused bicyclic derivative of 4-hydroxypyrrolidine and imidazolidinone as a new anti-HCV agent. VIROLOGY[J]. 2023, 第 9 作者  通讯作者  586: 91-104, http://dx.doi.org/10.1016/j.virol.2023.07.012.
[6] Chaolun Liu, Mingzhe Guo, Lin Han, Jie Lu, Xiaogang Xiang, Qing Xie, Janin Nouhin, Veasna Duong, Yimin Tong, Jin Zhong. Construction and characterization of a new hepatitis C virus genotype 6a subgenomic replicon that is prone to render the sofosbuvir resistance. Journal of medical virology[J]. 2023, 第 10 作者  通讯作者  https://onlinelibrary.wiley.com/doi/10.1002/jmv.29103.
[7] Leumi, Steve, Guo, Mingzhe, Lu, Jie, Wang, Zhaoning, Gan, Tianyu, Han, Lin, Ngari, Jackline, Tong, Yimin, Xiang, Xiaogang, Xie, Qing, Wang, Lanfeng, Zhong, Jin. Identification of a novel replication-competent hepatitis C virus variant that confers the sofosbuvir resistance. ANTIVIRAL RESEARCH[J]. 2022, 第 12 作者  通讯作者  197: http://dx.doi.org/10.1016/j.antiviral.2021.105224.
[8] Wei, Shukun, Hu, Xiaoyou, Du, Lingyu, Zhao, Linlin, Xue, Hongjuan, Liu, Chaolun, Chou, James J, Zhong, Jin, Tong, Yimin, Wang, Shuqing, OuYang, Bo. Inhibitor Development against p7 Channel in Hepatitis C Virus. MOLECULES[J]. 2021, 第 8 作者26(5): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961618/.
[9] Tong, Yimin, Shi, Gansheng, Hu, Gaowei, Hu, Xiaoyou, Han, Lin, Xie, Xiaofeng, Xu, Yongfen, Zhang, Rong, Sun, Jing, Zhong, Jin. Photo-catalyzed TiO2 inactivates pathogenic viruses by attacking viral genome. CHEMICAL ENGINEERING JOURNAL[J]. 2021, 第 10 作者  通讯作者  414: 128788-128788, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857067/.
[10] Yi, Chunyan, Xia, Jing, He, Lan, Ling, Zhiyang, Wang, Xuesong, Yan, Yu, Wang, Jiangjun, Zhao, Xinhao, Fan, Weiguo, Sun, Xiaoyu, Zhang, Ronghua, Ye, Sheng, Zhang, Rongguang, Xu, Yongfen, Ma, Liyan, Zhang, Yaguang, Zhou, Honglin, Huang, Zhong, Niu, Junqi, Long, Gang, Lu, Junxia, Zhong, Jin, Sun, Bing. Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2021, 第 22 作者  通讯作者  18(3): 675-685, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7116601&detailType=1.
[11] Liang, Yisha, Zhang, Guigen, Li, Qiheng, Han, Lin, Hu, Xiaoyou, Guo, Yu, Tao, Wanyin, Zhao, Xiaomin, Guo, Mingzhe, Gan, Tianyu, Tong, Yimin, Xu, Yongfen, Zhou, Zhuo, Ding, Qiang, Wei, Wensheng, Zhong, Jin. TRIM26 is a critical host factor for HCV replication and contributes to host tropism. SCIENCE ADVANCES[J]. 2021, 第 16 作者  通讯作者  7(2): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793585/.
[12] Tao Yu, Qiankun Yang, Fangling Tian, Haishuang Chang, Zhenzheng Hu, Bowen Yu, Lin Han, Yifan Xing, Yaming Jiu, Yongning He, Jin Zhong. Glycometabolism regulates hepatitis C virus release. PLOS PATHOGENS[J]. 2021, 第 11 作者  通讯作者  17(7): http://dx.doi.org/10.1371/journal.ppat.1009746.
[13] Xi Kang, Xi Chen, Ying He, Deyin Guo, Lin Guo, Jin Zhong, HongBing Shu. Corrigendum to "DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication" Virology 435 (2013) 385–394. VIROLOGY. 2021, 第 6 作者557: 101-102, http://dx.doi.org/10.1016/j.virol.2021.01.013.
[14] He, Zhenliang, Ye, Sichao, Xing, Yifan, Jiu, Yaming, Zhong, Jin. UNC93B1 curbs cytosolic DNA signaling by promoting STING degradation. EUROPEAN JOURNAL OF IMMUNOLOGY[J]. 2021, 第 5 作者  通讯作者  51(7): 1672-1685, http://dx.doi.org/10.1002/eji.202048901.
[15] Leumi, Steve, El Kassas, Mohamed, Zhong, Jin. Hepatitis C virus genotype 4: A poorly characterized endemic genotype. JOURNAL OF MEDICAL VIROLOGY. 2021, 第 3 作者  通讯作者  93(11): 6079-6088, http://dx.doi.org/10.1002/jmv.27165.
[16] Ju, Xiaohui, Zhu, Yunkai, Wang, Yuyan, Li, Jingrui, Zhang, Jiaxing, Gong, Mingli, Ren, Wenlin, Li, Sai, Zhong, Jin, Zhang, Linqi, Zhang, Qiangfeng Cliff, Zhang, Rong, Ding, Qiang. A novel cell culture system modeling the SARS-CoV-2 life cycle. PLOS PATHOGENS[J]. 2021, 第 9 作者17(3): https://doaj.org/article/df280045ebf4425eac4ddda8b2cee92f.
[17] Tianyu Gan, Dihan Zhou, Yi Huang, Shuqi Xiao, Ziyue Ma, Xiaoyou Hu, Yimin Tong, Huimin Yan, Jin Zhong. Development of a New Reverse Genetics System for Ebola Virus. MSPHERE[J]. 2021, 第 9 作者  通讯作者  6(3): http://dx.doi.org/10.1128/mSphere.00235-21.
[18] Xu, Xin, Peng, Ruchao, Peng, Qi, Wang, Min, Xu, Ying, Liu, Sheng, Tian, Xiaolin, Deng, Haiteng, Tong, Yimin, Hu, Xiaoyou, Zhong, Jin, Wang, Peiyi, Qi, Jianxun, Gao, George F, Shi, Yi. Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. NATURE MICROBIOLOGY[J]. 2021, 第 11 作者6(7): 921-+, http://dx.doi.org/10.1038/s41564-021-00916-w.
[19] Kang, Xi, Chen, Xi, He, Ying, Guo, Deyin, Guo, Lin, Zhong, Jin, Shu, HongBing. DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication (vol 435, pg 385, 2013). VIROLOGY. 2021, 第 6 作者  通讯作者  557: 101-102, http://dx.doi.org/10.1016/j.virol.2021.01.013.
[20] Qi, Yue, Han, Lin, Qi, Yanfei, Jin, Xia, Zhang, Bo, Niu, Junqi, Zhong, Jin, Xu, Yongfen. Anti-flavivirus activity of polyoxometalate. ANTIVIRAL RESEARCH[J]. 2020, 第 7 作者179: http://dx.doi.org/10.1016/j.antiviral.2020.104813.
[21] 张冬梅, 姜世勃, 石正丽, 谭文杰, 卢洪洲, 曹彬, 张文宏, 刘叔文, 钟劲, 肖庚富, 谢幼华, 邓凯, 赵金存, 杨子峰, 宋敬东, 陆路, 黄竞荷, 应天雷, 王乔, 施莽, 徐建青, 安静, 鲁凤民, 高福, 舒跃龙, 郭德银. 关于新型冠状病毒命名的思考与建议. 中国科技术语[J]. 2020, 第 9 作者22(2): 5-10, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=KJSY202002003&v=MDAwNDFyQ1VSN3FlWnVkdUZ5em5VNzdJTGlmWWQ3RzRITkhNclk5Rlo0UjhlWDFMdXhZUzdEaDFUM3FUcldNMUY=.
[22] Yang, Jingjing, Xu, Yongfen, Yan, Yunzheng, Li, Wei, Zhao, Lei, Dai, Qingsong, Li, Yuexiang, Li, Song, Zhong, Jin, Cao, Ruiyuan, Zhong, Wu. Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections. ACS INFECTIOUS DISEASES[J]. 2020, 第 9 作者  通讯作者  6(5): 832-843, http://dx.doi.org/10.1021/acsinfecdis.9b00376.
[23] Zhong Jing. IL-1β enhances anti-viral effect of IFN-α on HCV replication by negatively modulating ERK2 activation.. ACS Infect Dis.. 2020, 第 1 作者  通讯作者  
[24] 谢磊, 钟劲. 2020年度诺奖解读. 科学世界[J]. 2020, 第 2 作者6-7, http://lib.cqvip.com/Qikan/Article/Detail?id=7103172872.
[25] Yan, Yu, Wang, Xuesong, Lou, Peilan, Hu, Zhenzheng, Qu, Panke, Li, Dapeng, Li, Qingchao, Xu, Yongfen, Niu, Junqi, He, Yongning, Zhong, Jin, Zhong, Huang. A Nanoparticle-Based Hepatitis C Virus Vaccine With Enhanced Potency. JOURNAL OF INFECTIOUS DISEASES[J]. 2020, 第 11 作者221(8): 1304-1314, http://dx.doi.org/10.1093/infdis/jiz228.
[26] 李庆超, 钟劲. 分子生物学技术推进丙型肝炎病毒的发现和研究——2020年诺贝尔生理学或医学奖解读. 自然杂志[J]. 2020, 第 2 作者42(6): 7, http://lib.cqvip.com/Qikan/Article/Detail?id=7103621479.
[27] Xu, Ling, Yu, Dandan, Peng, Li, Wu, Yong, Fan, Yu, Gu, Tianle, Yao, YuLin, Zhong, Jin, Chen, Xinwen, Yao, YongGang. An Alternative Splicing of Tupaia STING Modulated Anti-RNA Virus Responses by Targeting MDA5-LGP2 and IRF3. JOURNAL OF IMMUNOLOGY[J]. 2020, 第 8 作者204(12): 3191-3204, https://www.webofscience.com/wos/woscc/full-record/WOS:000540261500014.
[28] Xu, Yongfen, Long, Gang, Zhong, Jin. Discovery and research of hepatitis C virus-Thoughts from the 2020 Nobel Prize in Physiology or Medicine. CHINESE SCIENCE BULLETIN-CHINESE[J]. 2020, 第 3 作者  通讯作者  65(36): 4177-4181, 
[29] Xu, Ling, Yu, Dandan, Yao, YuLin, Gu, Tianle, Zheng, Xiao, Wu, Yong, Luo, RongHua, Zheng, YongTang, Zhong, Jin, Yao, YongGang. Tupaia MAVS Is a Dual Target during Hepatitis C Virus Infection for Innate Immune Evasion and Viral Replication via NF-kappa B. JOURNAL OF IMMUNOLOGY[J]. 2020, 第 9 作者205(8): 2091-2099, https://www.webofscience.com/wos/woscc/full-record/WOS:000578996300012.
[30] Zhong Jing. A novel approach to display structural proteins of HCV quasispecies in patients reveals a key role of E2 HVR1 in viral evolution.. J. Virology. 2020, 第 1 作者  通讯作者  
[31] 徐咏芬, 龙钢, 钟劲. 丙型肝炎病毒的发现及研究——从2020年度诺贝尔生理学或医学奖谈起. 科学通报[J]. 2020, 第 3 作者65(36): 4177-4181, http://lib.cqvip.com/Qikan/Article/Detail?id=7104061890.
[32] Xing, Yifan, Wen, Zeyu, Gao, Wei, Lin, Zhekai, Zhong, Jin, Jiu, Yaming. Multifaceted Functions of Host Cell Caveolae/Caveolin-1 in Virus Infections. VIRUSES-BASEL. 2020, 第 5 作者12(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000565860200004.
[33] Zhong Jing. A nanoparticle-based HCV vaccine with enhanced potency.. Journal of Infectious Diseases. 2020, 第 1 作者  通讯作者  
[34] Zhong Jing. Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody.. Cell Mol Immunol.. 2020, 第 1 作者  通讯作者  
[35] Zhang, Weihong, Xu, Yongfen, Zhao, Fanfan, Tarbe, Marion, Zhou, Shuru, Wang, Weihong, Zhang, Shengyuan, Zhang, Wei, Xu, Qiuping, Shi, Lina, Yuan, Feng, Lin, Xinwen, Liu, Shuai, Sun, Jing, Zhao, Jincun, Yang, Yaling, Liang, Xiaozhen, Zhong, Jin, Long, Gang, Qin, Chengfeng, Leng, Qibin, Tang, Hong. The pre-existing cellular immunity to Japanese encephalitis virus heterotypically protects mice from Zika virus infection. SCIENCE BULLETIN[J]. 2020, 第 18 作者65(5): 402-409, http://dx.doi.org/10.1016/j.scib.2019.11.006.
[36] Guo, Mingzhe, Ye, Liqing, Yu, Tao, Han, Lin, Li, Qingchao, Lou, Peilan, Gan, Tianyu, Jin, Xia, Xiao, Hui, Meng, Guangxun, Zhong, Jin, Xu, Yongfen. IL-1 beta Enhances the Antiviral Effect of IFN-alpha on HCV Replication by Negatively Modulating ERK2 Activation. ACS INFECTIOUS DISEASES[J]. 2020, 第 11 作者  通讯作者  6(7): 1708-1718, http://dx.doi.org/10.1021/acsinfecdis.9b00506.
[37] Shin, EuiCheol, Han, Ji Won, Kang, Wonseok, Kato, Takanobu, Kim, SeongJun, Zhong, Jin, Kim, Seungtaek, Park, SuHyung, Sung, Pil Soo, Watashi, Koichi, Park, Jun Yong, Windisch, Marc P, Oh, JongWon, Wakita, Takaji, Han, KwangHyub, Jang, Sung Key. The Beginning of Ending Hepatitis C Virus: A Summary of the 26th International Symposium on Hepatitis C Virus and Related Viruses. VIRUSES-BASEL[J]. 2020, 第 6 作者12(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000525486800043.
[38] Longxing Cao, Bowen Yu, Dandan Kong, Qian Cong, Tao Yu, Zibo Chen, Zhenzheng Hu, Haishuang Chang, Jin Zhong, David Baker, Yongning He. Functional expression and characterization of the envelope glycoprotein E1E2 heterodimer of hepatitis C virus. PLOS PATHOGENS[J]. 2019, 第 9 作者15(5): https://doaj.org/article/32f54df5591f4e1db5a6c1c0ef660190.
[39] Shu, Ting, Gan, Tianyu, Bai, Peng, Wang, Xiaotong, Qian, Qi, Zhou, Hui, Cheng, Qi, Qiu, Yang, Yin, Lei, Zhong, Jin, Zhou, Xi. Ebola virus VP35 has novel NTPase and helicase-like activities. NUCLEIC ACIDS RESEARCH[J]. 2019, 第 10 作者47(11): 5837-5851, 
[40] Li, Zheng, Yao, Fujia, Xue, Guang, Xu, Yongfen, Niu, Junling, Cui, Mengmeng, Wang, Hongbin, Wu, Shuxian, Lu, Ailing, Zhong, Jin, Meng, Guangxun. Antiviral effects of simeprevir on multiple viruses. ANTIVIRAL RESEARCH[J]. 2019, 第 10 作者172: http://dx.doi.org/10.1016/j.antiviral.2019.104607.
[41] Guo, Mingzhe, Lu, Jie, Gan, Tianyu, Xiang, Xiaogang, Xu, Yongfen, Xie, Qing, Zhong, Jin. Construction and characterization of Genotype-3 hepatitis C virus replicon revealed critical genotype-3-specific polymorphism for drug resistance and viral fitness. ANTIVIRAL RESEARCH[J]. 2019, 第 7 作者  通讯作者  171: http://dx.doi.org/10.1016/j.antiviral.2019.104612.
[42] Wang, Xuesong, Yan, Yu, Gan, Tianyu, Yang, Xi, Li, Dapeng, Zhou, Dongming, Sun, Qiang, Huang, Zhong, Zhong, Jin. A trivalent HCV vaccine elicits broad and synergistic polyclonal antibody response in mice and rhesus monkey. GUT[J]. 2019, 第 9 作者  通讯作者  68(1): 140-149, 
[43] Huabin Liang, Jinyi Tang, Zhihua Liu, Yuanhua Liu, Yuanyuan Huang, Yongfen Xu, Pei Hao, Zhinan Yin, Jin Zhong, Lilin Ye, Xia Jin, Haikun Wang. ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice. NATURE COMMUNICATIONS[J]. 2019, 第 9 作者10(1): 1-16, http://dx.doi.org/10.1038/s41467-019-11754-0.
[44] Liang, Yisha, Cao, Xuezhi, Ding, Qiang, Zhao, Yanan, He, Zhenliang, Zhong, Jin. Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway. PLOS PATHOGENS[J]. 2018, 第 6 作者  通讯作者  14(5): https://doaj.org/article/ab6c8fac261f42f4800d9ba7b2805642.
[45] Zhong Jing. NEURL3 is an inducible antiviral effector to inhibit HCV assembly by targeting viral E1 glycoprotein.. J Virol.. 2018, 第 1 作者  通讯作者  
[46] 钟劲. 丙型肝炎病毒NS3蛋白酶抑制剂药物及其耐药信息数据库的建立和应用. 临床肝胆病杂志. 2018, 第 1 作者  通讯作者  
[47] Xuesong Sang, Yihui Cheni, Wei Chen, Jing Xie, Guangxun Meng, Jin Zhong, Taisheng Li, Ailing Lu. Celastrol specifically inhibits the activation of NLRP3 inflammasome. 中国科学：生命科学英文版[J]. 2018, 第 6 作者61(3): 355-357, http://lib.cqvip.com/Qikan/Article/Detail?id=674665937.
[48] Sang, Xuesong, Chen, Yihui, Chen, Wei, Xie, Jing, Meng, Guangxun, Zhong, Jin, Li, Taisheng, Lu, Ailing. Celastrol specifically inhibits the activation of NLRP3 inflammasome. SCIENCE CHINA-LIFE SCIENCES[J]. 2018, 第 6 作者61(3): 355-357, http://lib.cqvip.com/Qikan/Article/Detail?id=674665937.
[49] 颜雨, 王雪松, 黄忠, 钟劲. 丙型肝炎预防性疫苗开发的需求、挑战和进展. 中国细胞生物学学报[J]. 2018, 第 4 作者40(3): 303-308, http://lib.cqvip.com/Qikan/Article/Detail?id=675014387.
[50] Zhao, Fanfan, Xu, Yongfen, Lavillette, Dimitri, Zhong, Jin, Zou, Gang, Long, Gang. Negligible contribution of M2634V substitution to ZIKV pathogenesis in AG6 mice revealed by a bacterial promoter activity reduced infectious clone. SCIENTIFIC REPORTS[J]. 2018, 第 4 作者8(1): http://dx.doi.org/10.1038/s41598-018-28890-0.
[51] Zhao, Yanan, Cao, Xuezhi, Guo, Mingzhe, Wang, Xuesong, Yu, Tao, Ye, Liqing, Han, Lin, Hei, Lei, Tao, Wanyin, Tong, Yimin, Xu, Yongfen, Zhong, Jin. Neuralized E3 Ubiquitin Protein Ligase 3 Is an Inducible Antiviral Effector That Inhibits Hepatitis C Virus Assembly by Targeting Viral E1 Glycoprotein. JOURNAL OF VIROLOGY[J]. 2018, 第 12 作者  通讯作者  92(21): https://www.webofscience.com/wos/woscc/full-record/WOS:000447139100017.
[52] 颜雨, 王雪松, 钟劲. 三价HCV疫苗在小鼠和恒河猴诱导产生具有协同作用的广谱多克隆抗体反应. 临床肝胆病杂志[J]. 2018, 第 3 作者34(1): 79-79, https://lcgdbzz.org/article/id/LCGD201801022.
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（ 1 ） 丙型肝炎病毒感染及防治的基础研究, 主持, 国家级, 2009-01--2013-08
（ 2 ） Subversion of the IFN signaling pathway by HCV: ROLE OF THE VIRUS CORE PROTEIN AS IFN ANTAGONIST DUE TO ITS INTERACTION WITH MICROTUBULE NETWORK., 主持, 研究所（学校）, 2010-01--2011-12
（ 3 ） 基于反式互补的新型丙型肝炎病毒细胞感染模型的建立及其在丙肝研究中的应用, 主持, 国家级, 2012-01--2015-12
（ 4 ） 难治性丙肝转归预测预警的研究, 主持, 国家级, 2012-01--2015-12
（ 5 ） NS3蛋白N末端α螺旋结构参与HCV病毒颗粒组装的机制研究, 主持, 国家级, 2013-01--2016-12
（ 6 ） 丙型肝炎病毒诱导和逃逸宿主细胞干扰素信号通路的机制研究, 主持, 国家级, 2014-01--2018-12
（ 7 ） 慢性丙型病毒性肝炎免疫逃逸与免疫病理研究, 主持, 国家级, 2015-01--2019-08
（ 8 ） 难治性丙型肝炎生物学特性及其创新治疗方案的前期研究, 主持, 国家级, 2008-01--2011-12

（1）Development and application of a novel Ebola virus replicon model that stably replicates a viral mini-genome.   2016-04-13
（2）How hepatocytes sense HCV infection to induce innate immunity.   2016-01-22
（3）The old and new challenges in the translational and basic HCV research.   2016-01-08
（4）Hepatitis C Virus and Host Innate Immunity.   2015-10-19
（5）Hepatitis C virus and host interferon responses.   2015-05-13
（6）Hepatitis C virus and host interferon responses.   2015-05-13

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