基本信息
钟劲  男  博导  中国科学院上海巴斯德研究所
电子邮件: jzhong@sibs.ac.cn
通信地址: 上海市岳阳路生命科学大楼B-611
邮政编码: 200031

研究领域

丙型肝炎病毒(HCV)能导致急性和慢性肝炎以及肝癌,并且已成为一个世界性的人类健康问题。目前在全世界有超过1.7亿人感染了丙型肝炎病毒,在中国则达到了3800万。现在还没有预防HCV感染的疫苗,而干扰素治疗作为目前唯一被批准的治疗手段有效率不高并且有强烈的副作用。由于缺乏一个合适的细胞培养模型,HCV的研究长期以来受到很大的阻碍。最近在HCV感染的细胞培养模型方面的突破性进展为研究HCV的整个生命周期提供了一个极为有效的工具和手段。我们实验室的主要研究方向是利用这个新建立的细胞培养模型在分子水平上研究HCV感染的生物学机制以及病毒-宿主之间的相互作用。我们希望通过进一步了解病毒感染宿主细胞的机制以及宿主是如何限制病毒的感染,我们将能够找到更好的途径和手段来预防和治疗HCV的感染。

招生信息

   
招生专业
071005-微生物学
071009-细胞生物学
招生方向
病毒学,免疫学
抗病毒药物筛选

教育背景

1997-08--2003-08   美国德克萨斯大学   博士
1994-09--1997-07   北京大学   硕士
1990-09--1994-07   四川大学   学士
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
2016-01~现在, 中国科学院, 特聘研究员(特聘核心骨干)
2013-01~现在, 上海科技大学, 特聘教授
2007-01~现在, 中国科学院上海巴斯德研究所, 研究员,研究组长,所长助理
2003-09~2006-12,美国Scripps研究院, 博士后,研究助理
社会兼职
2011-01-01-今,中国微生物学学会病毒学专业委员会, 委员
2010-01-01-今,中华医学会医学病毒学分会, 委员
2007-01-01-今,上海微生物学会, 理事

教授课程

病毒学

专利与奖励

   
奖励信息
(1) 法国驻华使馆“2015 Emergences”奖, 其他, 2015
(2) 中科院“优秀研究生指导教师”奖, 部委级, 2014
(3) 国务院政府特殊津贴专家, , 国家级, 2013
(4) 中科院上海分院杰出青年科技创新人才提名奖, , 院级, 2012
(5) 中科院“朱李月华”优秀教师奖, , 院级, 2012
(6) 优秀青年人才, , 院级, 2010
(7) 法国人才创新奖, , 其他, 2009
(8) ****, , 院级, 2008
专利成果
( 1 ) 9,10-蒽醌类化合物的应用, 发明, 2012, 第 2 作者, 专利号: ZL 2008 1 0203112.1
( 2 ) 黄酮类化合物或含其的植物提取物的应用, 发明, 2009, 第 2 作者, 专利号: 200910150374.0
( 3 ) Use of 9,10-Anthraquinone Compounds, 发明, 2009, 第 2 作者, 专利号: PCT/CN2009/075075
( 4 ) 一种感染能力增强的重组嵌合型丙型肝炎病毒株。, 发明, 2013, 第 1 作者, 专利号: 201310172776.7
( 5 ) 构建基因2a型丙型肝炎病毒临床分离株细胞培养模型的方法。 , 发明, 2013, 第 1 作者, 专利号: 201310479702.8
( 6 ) 一种丙型肝炎病毒重组蛋白的制备及其应用, 发明, 2014, 第 2 作者, 专利号: 201410367643X
( 7 ) 可用于抗病毒药物筛选的埃博拉病毒复制子模型及其应用, 发明, 2015, 第 1 作者, 专利号: 201510390783.3
( 8 ) 一种丙型肝炎病毒三价亚单位疫苗的制备及应用, 发明, 2016, 第 1 作者, 专利号: 201610595121.4
( 9 ) 一种展示丙型肝炎病毒包膜蛋白E2 的纳米颗粒的制备及应用, 发明, 2016, 第 2 作者, 专利号: 201610595142.6

出版信息

   
发表论文
[1] Leumi, Steve, Guo, Mingzhe, Lu, Jie, Wang, Zhaoning, Gan, Tianyu, Han, Lin, Ngari, Jackline, Tong, Yimin, Xiang, Xiaogang, Xie, Qing, Wang, Lanfeng, Zhong, Jin. Identification of a novel replication-competent hepatitis C virus variant that confers the sofosbuvir resistance. ANTIVIRAL RESEARCH[J]. 2022, 197: http://dx.doi.org/10.1016/j.antiviral.2021.105224.
[2] Tong, Yimin, Shi, Gansheng, Hu, Gaowei, Hu, Xiaoyou, Han, Lin, Xie, Xiaofeng, Xu, Yongfen, Zhang, Rong, Sun, Jing, Zhong, Jin. Photo-catalyzed TiO2 inactivates pathogenic viruses by attacking viral genome. CHEMICAL ENGINEERING JOURNAL[J]. 2021, 414: 128788-128788, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857067/.
[3] Wei, Shukun, Hu, Xiaoyou, Du, Lingyu, Zhao, Linlin, Xue, Hongjuan, Liu, Chaolun, Chou, James J, Zhong, Jin, Tong, Yimin, Wang, Shuqing, OuYang, Bo. Inhibitor Development against p7 Channel in Hepatitis C Virus. MOLECULES[J]. 2021, 26(5): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961618/.
[4] Chunyan Yi, Jing Xia, Lan He, Zhiyang Ling, Xuesong Wang, Yu Yan, Jiangjun Wang, Xinhao Zhao, Weiguo Fan, Xiaoyu Sun, Ronghua Zhang, Sheng Ye, Rongguang Zhang, Yongfen Xu, Liyan Ma, Yaguang Zhang, Honglin Zhou, Zhong Huang, Junqi Niu, Gang Long, Junxia Lu, Jin Zhong, Bing Sun. Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2021, 18(3): 675-685, https://www.webofscience.com/wos/woscc/full-record/WOS:000522605400001.
[5] Liang, Yisha, Zhang, Guigen, Li, Qiheng, Han, Lin, Hu, Xiaoyou, Guo, Yu, Tao, Wanyin, Zhao, Xiaomin, Guo, Mingzhe, Gan, Tianyu, Tong, Yimin, Xu, Yongfen, Zhou, Zhuo, Ding, Qiang, Wei, Wensheng, Zhong, Jin. TRIM26 is a critical host factor for HCV replication and contributes to host tropism. SCIENCE ADVANCES[J]. 2021, 7(2): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793585/.
[6] Tao Yu, Qiankun Yang, Fangling Tian, Haishuang Chang, Zhenzheng Hu, Bowen Yu, Lin Han, Yifan Xing, Yaming Jiu, Yongning He, Jin Zhong. Glycometabolism regulates hepatitis C virus release. PLOS PATHOGENS[J]. 2021, 17(7): http://dx.doi.org/10.1371/journal.ppat.1009746.
[7] Xi Kang, Xi Chen, Ying He, Deyin Guo, Lin Guo, Jin Zhong, HongBing Shu. Corrigendum to "DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication" Virology 435 (2013) 385–394. Virology. 2021, 557: 101-102, http://dx.doi.org/10.1016/j.virol.2021.01.013.
[8] He, Zhenliang, Ye, Sichao, Xing, Yifan, Jiu, Yaming, Zhong, Jin. UNC93B1 curbs cytosolic DNA signaling by promoting STING degradation. EUROPEAN JOURNAL OF IMMUNOLOGY[J]. 2021, 51(7): 1672-1685, http://dx.doi.org/10.1002/eji.202048901.
[9] Leumi, Steve, El Kassas, Mohamed, Zhong, Jin. Hepatitis C virus genotype 4: A poorly characterized endemic genotype. JOURNAL OF MEDICAL VIROLOGYnull. 2021, 93(11): 6079-6088, http://dx.doi.org/10.1002/jmv.27165.
[10] Tianyu Gan, Dihan Zhou, Yi Huang, Shuqi Xiao, Ziyue Ma, Xiaoyou Hu, Yimin Tong, Huimin Yan, Jin Zhong. Development of a New Reverse Genetics System for Ebola Virus. MSPHERE[J]. 2021, 6(3): http://dx.doi.org/10.1128/mSphere.00235-21.
[11] Ju, Xiaohui, Zhu, Yunkai, Wang, Yuyan, Li, Jingrui, Zhang, Jiaxing, Gong, Mingli, Ren, Wenlin, Li, Sai, Zhong, Jin, Zhang, Linqi, Zhang, Qiangfeng Cliff, Zhang, Rong, Ding, Qiang. A novel cell culture system modeling the SARS-CoV-2 life cycle. PLOS PATHOGENS[J]. 2021, 17(3): https://doaj.org/article/df280045ebf4425eac4ddda8b2cee92f.
[12] Xu, Xin, Peng, Ruchao, Peng, Qi, Wang, Min, Xu, Ying, Liu, Sheng, Tian, Xiaolin, Deng, Haiteng, Tong, Yimin, Hu, Xiaoyou, Zhong, Jin, Wang, Peiyi, Qi, Jianxun, Gao, George F, Shi, Yi. Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. NATURE MICROBIOLOGY[J]. 2021, 6(7): 921-+, http://dx.doi.org/10.1038/s41564-021-00916-w.
[13] Kang, Xi, Chen, Xi, He, Ying, Guo, Deyin, Guo, Lin, Zhong, Jin, Shu, HongBing. DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication (vol 435, pg 385, 2013). VIROLOGYnull. 2021, 557: 101-102, http://dx.doi.org/10.1016/j.virol.2021.01.013.
[14] Qi, Yue, Han, Lin, Qi, Yanfei, Jin, Xia, Zhang, Bo, Niu, Junqi, Zhong, Jin, Xu, Yongfen. Anti-flavivirus activity of polyoxometalate. ANTIVIRAL RESEARCH[J]. 2020, 179: http://dx.doi.org/10.1016/j.antiviral.2020.104813.
[15] 张冬梅, 姜世勃, 石正丽, 谭文杰, 卢洪洲, 曹彬, 张文宏, 刘叔文, 钟劲, 肖庚富, 谢幼华, 邓凯, 赵金存, 杨子峰, 宋敬东, 陆路, 黄竞荷, 应天雷, 王乔, 施莽, 徐建青, 安静, 鲁凤民, 高福, 舒跃龙, 郭德银. 关于新型冠状病毒命名的思考与建议. 中国科技术语[J]. 2020, 22(2): 5-10, http://lib.cqvip.com/Qikan/Article/Detail?id=7101464350.
[16] Yang, Jingjing, Xu, Yongfen, Yan, Yunzheng, Li, Wei, Zhao, Lei, Dai, Qingsong, Li, Yuexiang, Li, Song, Zhong, Jin, Cao, Ruiyuan, Zhong, Wu. Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections. ACS INFECTIOUS DISEASES[J]. 2020, 6(5): 832-843, http://dx.doi.org/10.1021/acsinfecdis.9b00376.
[17] Zhong Jing. IL-1β enhances anti-viral effect of IFN-α on HCV replication by negatively modulating ERK2 activation.. ACS Infect Dis.. 2020, [18] 谢磊, 钟劲. 2020年度诺奖解读. 科学世界[J]. 2020, 6-7, http://lib.cqvip.com/Qikan/Article/Detail?id=7103172872.
[19] Yan, Yu, Wang, Xuesong, Lou, Peilan, Hu, Zhenzheng, Qu, Panke, Li, Dapeng, Li, Qingchao, Xu, Yongfen, Niu, Junqi, He, Yongning, Zhong, Jin, Zhong, Huang. A Nanoparticle-Based Hepatitis C Virus Vaccine With Enhanced Potency. JOURNAL OF INFECTIOUS DISEASES[J]. 2020, 221(8): 1304-1314, https://www.webofscience.com/wos/woscc/full-record/WOS:000562359700020.
[20] Xu, Ling, Yu, Dandan, Peng, Li, Wu, Yong, Fan, Yu, Gu, Tianle, Yao, YuLin, Zhong, Jin, Chen, Xinwen, Yao, YongGang. An Alternative Splicing of Tupaia STING Modulated Anti-RNA Virus Responses by Targeting MDA5-LGP2 and IRF3. JOURNAL OF IMMUNOLOGY[J]. 2020, 204(12): 3191-3204, https://www.webofscience.com/wos/woscc/full-record/WOS:000540261500014.
[21] 李庆超, 钟劲. 分子生物学技术推进丙型肝炎病毒的发现和研究——2020年诺贝尔生理学或医学奖解读. 自然杂志[J]. 2020, 42(6): 7-, http://lib.cqvip.com/Qikan/Article/Detail?id=7103621479.
[22] Xu, Yongfen, Long, Gang, Zhong, Jin. Discovery and research of hepatitis C virus-Thoughts from the 2020 Nobel Prize in Physiology or Medicine. CHINESE SCIENCE BULLETIN-CHINESE[J]. 2020, 65(36): 4177-4181, [23] Xu, Ling, Yu, Dandan, Yao, YuLin, Gu, Tianle, Zheng, Xiao, Wu, Yong, Luo, RongHua, Zheng, YongTang, Zhong, Jin, Yao, YongGang. Tupaia MAVS Is a Dual Target during Hepatitis C Virus Infection for Innate Immune Evasion and Viral Replication via NF-kappa B. JOURNAL OF IMMUNOLOGY[J]. 2020, 205(8): 2091-2099, https://www.webofscience.com/wos/woscc/full-record/WOS:000578996300012.
[24] Zhong Jing. A novel approach to display structural proteins of HCV quasispecies in patients reveals a key role of E2 HVR1 in viral evolution.. J. Virology. 2020, [25] 徐咏芬, 龙钢, 钟劲. 丙型肝炎病毒的发现及研究——从2020年度诺贝尔生理学或医学奖谈起. 科学通报[J]. 2020, 65(36): 4177-4181, http://lib.cqvip.com/Qikan/Article/Detail?id=7104061890.
[26] Xing, Yifan, Wen, Zeyu, Gao, Wei, Lin, Zhekai, Zhong, Jin, Jiu, Yaming. Multifaceted Functions of Host Cell Caveolae/Caveolin-1 in Virus Infections. VIRUSES-BASELnull. 2020, 12(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000565860200004.
[27] Zhong Jing. Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody.. Cell Mol Immunol.. 2020, [28] Zhong Jing. A nanoparticle-based HCV vaccine with enhanced potency.. Journal of Infectious Diseases. 2020, [29] Guo, Mingzhe, Ye, Liqing, Yu, Tao, Han, Lin, Li, Qingchao, Lou, Peilan, Gan, Tianyu, Jin, Xia, Xiao, Hui, Meng, Guangxun, Zhong, Jin, Xu, Yongfen. IL-1 beta Enhances the Antiviral Effect of IFN-alpha on HCV Replication by Negatively Modulating ERK2 Activation. ACS INFECTIOUS DISEASES[J]. 2020, 6(7): 1708-1718, http://dx.doi.org/10.1021/acsinfecdis.9b00506.
[30] Zhang, Weihong, Xu, Yongfen, Zhao, Fanfan, Tarbe, Marion, Zhou, Shuru, Wang, Weihong, Zhang, Shengyuan, Zhang, Wei, Xu, Qiuping, Shi, Lina, Yuan, Feng, Lin, Xinwen, Liu, Shuai, Sun, Jing, Zhao, Jincun, Yang, Yaling, Liang, Xiaozhen, Zhong, Jin, Long, Gang, Qin, Chengfeng, Leng, Qibin, Tang, Hong. The pre-existing cellular immunity to Japanese encephalitis virus heterotypically protects mice from Zika virus infection. SCIENCE BULLETIN[J]. 2020, 65(5): 402-409, http://dx.doi.org/10.1016/j.scib.2019.11.006.
[31] Shin, EuiCheol, Han, Ji Won, Kang, Wonseok, Kato, Takanobu, Kim, SeongJun, Zhong, Jin, Kim, Seungtaek, Park, SuHyung, Sung, Pil Soo, Watashi, Koichi, Park, Jun Yong, Windisch, Marc P, Oh, JongWon, Wakita, Takaji, Han, KwangHyub, Jang, Sung Key. The Beginning of Ending Hepatitis C Virus: A Summary of the 26th International Symposium on Hepatitis C Virus and Related Viruses. VIRUSES-BASEL[J]. 2020, 12(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000525486800043.
[32] Longxing Cao, Bowen Yu, Dandan Kong, Qian Cong, Tao Yu, Zibo Chen, Zhenzheng Hu, Haishuang Chang, Jin Zhong, David Baker, Yongning He. Functional expression and characterization of the envelope glycoprotein E1E2 heterodimer of hepatitis C virus. PLOS PATHOGENS[J]. 2019, 15(5): https://doaj.org/article/32f54df5591f4e1db5a6c1c0ef660190.
[33] Shu, Ting, Gan, Tianyu, Bai, Peng, Wang, Xiaotong, Qian, Qi, Zhou, Hui, Cheng, Qi, Qiu, Yang, Yin, Lei, Zhong, Jin, Zhou, Xi. Ebola virus VP35 has novel NTPase and helicase-like activities. NUCLEIC ACIDS RESEARCH[J]. 2019, 47(11): 5837-5851, [34] Li, Zheng, Yao, Fujia, Xue, Guang, Xu, Yongfen, Niu, Junling, Cui, Mengmeng, Wang, Hongbin, Wu, Shuxian, Lu, Ailing, Zhong, Jin, Meng, Guangxun. Antiviral effects of simeprevir on multiple viruses. ANTIVIRAL RESEARCH[J]. 2019, 172: http://dx.doi.org/10.1016/j.antiviral.2019.104607.
[35] Guo, Mingzhe, Lu, Jie, Gan, Tianyu, Xiang, Xiaogang, Xu, Yongfen, Xie, Qing, Zhong, Jin. Construction and characterization of Genotype-3 hepatitis C virus replicon revealed critical genotype-3-specific polymorphism for drug resistance and viral fitness. ANTIVIRAL RESEARCH[J]. 2019, 171: http://dx.doi.org/10.1016/j.antiviral.2019.104612.
[36] Wang, Xuesong, Yan, Yu, Gan, Tianyu, Yang, Xi, Li, Dapeng, Zhou, Dongming, Sun, Qiang, Huang, Zhong, Zhong, Jin. A trivalent HCV vaccine elicits broad and synergistic polyclonal antibody response in mice and rhesus monkey. GUT[J]. 2019, 68(1): 140-149, [37] Huabin Liang, Jinyi Tang, Zhihua Liu, Yuanhua Liu, Yuanyuan Huang, Yongfen Xu, Pei Hao, Zhinan Yin, Jin Zhong, Lilin Ye, Xia Jin, Haikun Wang. ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice. Nature Communications[J]. 2019, 10(1): 1-16, http://dx.doi.org/10.1038/s41467-019-11754-0.
[38] 钟劲. 丙型肝炎病毒NS3蛋白酶抑制剂药物及其耐药信息数据库的建立和应用. 临床肝胆病杂志. 2018, [39] Zhong Jing. NEURL3 is an inducible antiviral effector to inhibit HCV assembly by targeting viral E1 glycoprotein.. J Virol.. 2018, [40] Liang, Yisha, Cao, Xuezhi, Ding, Qiang, Zhao, Yanan, He, Zhenliang, Zhong, Jin. Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway. PLOS PATHOGENS[J]. 2018, 14(5): https://doaj.org/article/ab6c8fac261f42f4800d9ba7b2805642.
[41] Xuesong Sang, Yihui Cheni, Wei Chen, Jing Xie, Guangxun Meng, Jin Zhong, Taisheng Li, Ailing Lu. Celastrol specifically inhibits the activation of NLRP3 inflammasome. 中国科学:生命科学英文版[J]. 2018, 61(3): 355-357, http://lib.cqvip.com/Qikan/Article/Detail?id=674665937.
[42] Sang, Xuesong, Chen, Yihui, Chen, Wei, Xie, Jing, Meng, Guangxun, Zhong, Jin, Li, Taisheng, Lu, Ailing. Celastrol specifically inhibits the activation of NLRP3 inflammasome. SCIENCE CHINA-LIFE SCIENCES. 2018, 61(3): 355-357, http://lib.cqvip.com/Qikan/Article/Detail?id=674665937.
[43] 颜雨, 王雪松, 黄忠, 钟劲. 丙型肝炎预防性疫苗开发的需求、挑战和进展. 中国细胞生物学学报[J]. 2018, 40(3): 303-308, http://lib.cqvip.com/Qikan/Article/Detail?id=675014387.
[44] Zhao, Fanfan, Xu, Yongfen, Lavillette, Dimitri, Zhong, Jin, Zou, Gang, Long, Gang. Negligible contribution of M2634V substitution to ZIKV pathogenesis in AG6 mice revealed by a bacterial promoter activity reduced infectious clone. SCIENTIFIC REPORTS[J]. 2018, 8(1): http://dx.doi.org/10.1038/s41598-018-28890-0.
[45] Zhao, Yanan, Cao, Xuezhi, Guo, Mingzhe, Wang, Xuesong, Yu, Tao, Ye, Liqing, Han, Lin, Hei, Lei, Tao, Wanyin, Tong, Yimin, Xu, Yongfen, Zhong, Jin. Neuralized E3 Ubiquitin Protein Ligase 3 Is an Inducible Antiviral Effector That Inhibits Hepatitis C Virus Assembly by Targeting Viral E1 Glycoprotein. JOURNAL OF VIROLOGY[J]. 2018, 92(21): https://www.webofscience.com/wos/woscc/full-record/WOS:000447139100017.
[46] 颜雨, 王雪松, 钟劲. 三价HCV疫苗在小鼠和恒河猴诱导产生具有协同作用的广谱多克隆抗体反应. 临床肝胆病杂志[J]. 2018, 34(1): 79-79, http://lib.cqvip.com/Qikan/Article/Detail?id=76677168504849564849485050.
[47] Li, Jinqian, Feng, Shengjun, Liu, Xi, Guo, Mingzhe, Chen, Mingxiao, Chen, Yiyi, Rong, Liang, Xia, Jinyu, Zhou, Yuanping, Zhong, Jin, Li, YiPing. Identification of nucleotides in the 5 ' UTR and amino acids substitutions that are essential for the infectivity of 5 ' UTR-NS5A recombinant of hepatitis C virus genotype 1b (strain Con1). VIROLOGY[J]. 2018, 518: 253-263, http://dx.doi.org/10.1016/j.virol.2018.03.001.
[48] Wang, Hongbin, Li, Zheng, Niu, Junling, Xu, Yongfen, Ma, Li, Lu, Ailing, Wang, Xun, Qian, Zhikang, Huang, Zhong, Jin, Xia, Leng, Qibin, Wang, Jianhua, Zhong, Jin, Sun, Bing, Meng, Guangxun. Antiviral effects of ferric ammonium citrate. CELL DISCOVERY[J]. 2018, 4(1): https://doaj.org/article/0551ffba54c549f68bf2f35954839be5.
[49] Tong, Yimin, Lavillette, Dimitri, Li, Qingchao, Zhong, Jin. Role of Hepatitis C Virus Envelope Glycoprotein E1 in Virus Entry and Assembly. FRONTIERS IN IMMUNOLOGY[J]. 2018, 9: https://doaj.org/article/9e40d802ee914504ae4d573656be0b81.
[50] 谢磊, 李庆超, 钟劲. 丙型肝炎病毒直接抗病毒药物的耐药性研究进展. 中华传染病杂志[J]. 2018, 36(4): 254-256, http://lib.cqvip.com/Qikan/Article/Detail?id=675679471.
[51] Yisha Liang, Xuezhi Cao, Qiang Ding, Yanan Zhao, Zhenliang He, Jin Zhong. Correction: Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway.. PLoS Pathogens[J]. 2018, 14(11): https://doaj.org/article/dd45d81aa0384e43ab656fd33f2ef214.
[52] Li, Qingchao, Tong, Yimin, Xu, Yongfen, Niu, Junqi, Zhong, Jin. Genetic Analysis of Serum-Derived Defective Hepatitis C Virus Genomes Revealed Novel Viral cis Elements for Virus Replication and Assembly. JOURNAL OF VIROLOGY[J]. 2018, 92(7): https://www.webofscience.com/wos/woscc/full-record/WOS:000428409800040.
[53] Li, Dapeng, Wang, Xuesong, von Schaewen, Markus, Tao, Wanyin, Zhang, Yunfang, Heller, Brigitte, Hrebikova, Gabriela, Deng, Qiang, Sun, Qiang, Ploss, Alexander, Zhong, Jin, Huang, Zhong. Immunization With a Subunit Hepatitis C Virus Vaccine Elicits Pan-Genotypic Neutralizing Antibodies and Intrahepatic T-Cell Responses in Nonhuman Primates. JOURNAL OF INFECTIOUS DISEASES[J]. 2017, 215(12): 1824-1831, [54] Zhang, Chao, Hua, Rui, Cui, Yuanyuan, Wang, Shasha, Yan, Hongqing, Li, Dongmei, Zhang, Yonghong, Tu, Zhengkun, Hao, Pei, Chen, Xinyue, Zhong, Jin, Niu, Junqi, Jin, Xia. Comprehensive mapping of antigen specific T cell responses in hepatitis C virus infected patients with or without spontaneous viral clearance. PLOS ONE[J]. 2017, 12(2): https://doaj.org/article/1325cf04b06046f28ec605b0c0f30240.
[55] Cao, RuiYuan, Xu, Yongfen, Zhang, TianHong, Yang, JingJing, Yuan, Ye, Hao, Pei, Shi, Yi, Zhong, Jin, Zhong, Wu. Pediatric Drug Nitazoxanide: A Potential Choice for Control of Zika. OPEN FORUM INFECTIOUS DISEASES[J]. 2017, 4(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000405678200063.
[56] Tao, Wanyin, Gan, Tianyu, Lu, Jie, Zhong, Jin. A profiling study of a newly developed HCVcc strain PR63cc's sensitivity to direct-acting antivirals. ANTIVIRAL RESEARCH[J]. 2017, 139: 18-24, http://dx.doi.org/10.1016/j.antiviral.2016.12.009.
[57] 钟劲. 2016年度“微生物学前沿”信息——丙型肝炎病毒疫苗研究进展. 工业微生物[J]. 2017, 47(1): 65-65, http://lib.cqvip.com/Qikan/Article/Detail?id=671291350.
[58] Zhong Jing. Functional analysis of HCV envelope protein E1 using a trans-complementation system reveals a dual role of a putative fusion peptide of E1 in both HCV entry and morphogenesis.. J. Virology. 2017, [59] Zhong Jing. LGP2 plays an essential role in HCV infection-induced interferon responses.. Hepatology,. 2017, [60] Tong, Yimin, Chi, Xiaojing, Yang, Wei, Zhong, Jin. Functional Analysis of Hepatitis C Virus (HCV) Envelope Protein E1 Using a trans-Complementation System Reveals a Dual Role of a Putative Fusion Peptide of E1 in both HCV Entry and Morphogenesis. JOURNAL OF VIROLOGY[J]. 2017, 91(7): https://www.webofscience.com/wos/woscc/full-record/WOS:000398833200028.
[61] Tao, Wanyin, Gan, Tianyu, Guo, Mingzhe, Xu, Yongfen, Zhong, Jin. Novel Stable Ebola Virus Minigenome Replicon Reveals Remarkable Stability of the Viral Genome. JOURNAL OF VIROLOGY[J]. 2017, 91(22): https://www.webofscience.com/wos/woscc/full-record/WOS:000414005400027.
[62] Yan, Yu, He, Ying, Boson, Bertrand, Wang, Xuesong, Cosset, FrancoisLoic, Zhong, Jin. A Point Mutation in the N-Terminal Amphipathic Helix alpha(0) in NS3 Promotes Hepatitis C Virus Assembly by Altering Core Localization to the Endoplasmic Reticulum and Facilitating Virus Budding. JOURNAL OF VIROLOGY[J]. 2017, 91(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000398098300033.
[63] Yang, Zaili, Wang, Xiaoning, Chi, Xiumei, Zhao, Fanfan, Guo, Jinxu, Ma, Pengjuan, Zhong, Jin, Niu, Junqi, Pan, Xiaoyu, Long, Gang. Neglected but Important Role of Apolipoprotein E Exchange in Hepatitis C Virus Infection (vol 90, pg 9632, 2016). JOURNAL OF VIROLOGY. 2017, 91(24): http://www.corc.org.cn/handle/1471x/2182808.
[64] Hei, Lei, Zhong, Jin. Laboratory of Genetics and Physiology 2 (LGP2) Plays an Essential Role in Hepatitis C Virus Infection-Induced Interferon Responses. HEPATOLOGY[J]. 2017, 65(5): 1478-1491, https://www.webofscience.com/wos/woscc/full-record/WOS:000399459800006.
[65] Zhong Jing. A point mutation in the N-terminal amphiphathic helix α0 in NS3 promotes HCV assembly by altering core localization to ER and facilitating virus budding.. J. Virology. 2017, [66] 黑蕾, 钟劲. LGP2在HCV感染诱导的干扰素应答中的关键作用. 临床肝胆病杂志[J]. 2017, 33(7): 1348-1348, http://lib.cqvip.com/Qikan/Article/Detail?id=672730924.
[67] Chi, Xiaojing, Niu, Yuqiang, Cheng, Min, Liu, Xiuying, Feng, Yetong, Zheng, Fuxiang, Fan, Jingjing, Li, Xiang, Jin, Qi, Zhong, Jin, Li, Ping, Yang, Wei. Identification of a Potent and Broad-Spectrum Hepatitis C Virus Fusion Inhibitory Peptide from the E2 Stem Domain. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000374947200002.
[68] Yang, Zaili, Wang, Xiaoning, Chi, Xiumei, Zhao, Fanfan, Guo, Jinxu, Ma, Pengjuan, Zhong, Jin, Niu, Junqi, Pan, Xiaoyu, Long, Gang. Neglected but Important Role of Apolipoprotein E Exchange in Hepatitis C Virus Infection. JOURNAL OF VIROLOGY[J]. 2016, 90(21): 9632-9643, http://www.corc.org.cn/handle/1471x/2232997.
[69] Yang, Chen, Zhao, Xinhao, Sun, Dakang, Yang, Leilei, Chong, Chang, Pan, Yu, Chi, Xiumei, Gao, Yanhang, Wang, Moli, Shi, Xiaodong, Sun, Haibo, Lv, Juan, Gao, Yuanda, Zhong, Jin, Niu, Junqi, Sun, Bing. Interferon alpha (IFN alpha)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2016, 13(1): 94-102, https://www.webofscience.com/wos/woscc/full-record/WOS:000371996300010.
[70] Zhong Jing. Altered glycosylation patterns increase immunogenicity of a subunit HCV vaccine inducing neutralizing antibodies which confer protection in mice.. J Virol.. 2016, [71] Wu, Ruihong, Chi, Xiumei, Wang, Xiaomei, Sun, Haibo, Lv, Juan, Gao, Xiuzhu, Yu, Ge, Kong, Fei, Xu, Hongqin, Hua, Rui, Jiang, Jing, Sun, Bing, Zhong, Jin, Pan, Yu, Niu, Junqi. IFNL4 ss469415590 polymorphism contributes to treatment decisions in patients with chronic hepatitis C virus genotype 1b, but not 2a, infection. INFECTION GENETICS AND EVOLUTION[J]. 2016, 39: 132-140, http://dx.doi.org/10.1016/j.meegid.2016.01.020.
[72] Zhong Jing. A Profiling Study of a Newly Developed HCVcc Strain PR63cc’s Sensitivity to Direct-acting Antivirals.. Antiviral Research. 2016, [73] Sun Bing, Yang Chen, Zhao Xinhao, Sun Dakang, Yang Leilei, Chong Chang, Pan Yu, Chi Xiumei, Gao Yanhang, Wang Moli, Shi Xiaodong, Sun Haibo, Lv Juan, Gao Yuanda, Zhong Jin, Niu Junqi. Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A. Cellular & Molecular Immunology[J]. 2016, 13(1): 94-102, [74] Xu, Yongfen, Zhong, Jin. Innate immunity against hepatitis C virus. CURRENT OPINION IN IMMUNOLOGYnull. 2016, 42: 98-104, http://dx.doi.org/10.1016/j.coi.2016.06.009.
[75] Chen Yang, Xinhao Zhao, Dakang Sun, Leilei Yang, Chang Chong, Yu Pan, Xiumei Chi, Yanhang Gao, Moli Wang, Xiaodong Shi, Haibo Sun, Juan Lv, Yuanda Gao, Jin Zhong, Junqi Niu, Bing Sun. nterferon alpha (IFNα)-induced TRIM22 interrupts HCV 'eplication by ubiquitinating NS5A. 中国免疫学杂志:英文版[J]. 2016, 13(1): 94-102, http://lib.cqvip.com/Qikan/Article/Detail?id=667670156.
[76] Zhong Jing. IFN-λ4 desensitizes the response to IFN-α treatment in chronic hepatitis C through long-term induction of USP18.. J Gen Virol.. 2016, [77] Li, Dapeng, von Schaewen, Markus, Wang, Xuesong, Tao, Wanyin, Zhang, Yunfang, Li, Li, Heller, Brigitte, Hrebikova, Gabriela, Deng, Qiang, Ploss, Alexander, Zhong, Jin, Huang, Zhong. Altered Glycosylation Patterns Increase Immunogenicity of a Subunit Hepatitis C Virus Vaccine, Inducing Neutralizing Antibodies Which Confer Protection in Mice. JOURNAL OF VIROLOGY[J]. 2016, 90(23): 10486-10498, https://www.webofscience.com/wos/woscc/full-record/WOS:000389904500005.
[78] Mei, Ruqi, Chi, Xiumei, Wu, Ruihong, Xu, Hongqin, Wang, Xiaomei, Gao, Xiuzhu, Sun, Haibo, Lv, Juan, Yu, Ge, Kong, Fei, Jiang, Jing, Sun, Bing, Zhong, Jin, Pan, Yu, Niu, Junqi. Sustained viral response and treatment-induced cytopenia correlate with SLCs and KLF12 genotypes in interferon/ribavirin-treated Chinese chronic hepatitis C patients. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY[J]. 2016, 31(8): 1489-1497, http://dx.doi.org/10.1111/jgh.13290.
[79] Li, D, Huang, Z, Zhong, J. Hepatitis C virus vaccine development: old challenges and new opportunities. 国家科学评论:英文版[J]. 2015, 285-295, http://lib.cqvip.com/Qikan/Article/Detail?id=78658382504849534851484952.
[80] Chen, Yongzhi, He, Liang, Peng, Yanan, Shi, Xiaodong, Chen, Jizheng, Zhong, Jin, Chen, Xinwen, Cheng, Genhong, Deng, Hongyu. The hepatitis C virus protein NS3 suppresses TNF-alpha-stimulated activation of NF-kappa B by targeting LUBAC. SCIENCE SIGNALING[J]. 2015, 8(403): https://www.webofscience.com/wos/woscc/full-record/WOS:000365867000003.
[81] Meng, Zhanchao, Yu, Haixin, Li, Li, Tao, Wanyin, Chen, Hao, Wan, Ming, Yang, Peng, Edmonds, David J, Zhong, Jin, Li, Ang. Total synthesis and antiviral activity of indolosesquiterpenoids from the xiamycin and oridamycin families. NATURE COMMUNICATIONS[J]. 2015, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000350196900002.
[82] Xiang, Y, Tang, JJ, Tao, W, Cao, X, Song, BL, Zhong, J. Identification of cholesterol-25-hydroxylase as a novel host restriction factor as a part of primary innate immune responses against HCV infection.. 2015, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201804160009650LZ.
[83] Bai, Yadan, Xuan, Baoqin, Liu, Haiyan, Zhong, Jin, Yu, Dong, Qian, Zhikang. Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38. JOURNAL OF VIROLOGY[J]. 2015, 89(15): 7625-7635, https://www.webofscience.com/wos/woscc/full-record/WOS:000358277800016.
[84] Liu, Xiuying, Chi, Xiumei, Gong, Qiaoling, Gao, Lei, Niu, Yuqiang, Chi, Xiaojing, Cheng, Min, Si, Youhui, Wang, Maorong, Zhong, Jin, Niu, Junqi, Yang, Wei. Association of Serum Level of Growth Differentiation Factor 15 with Liver Cirrhosis and Hepatocellular Carcinoma. PLOS ONE[J]. 2015, 10(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000356444000072.
[85] Sun, Haibo, Pan, Yu, Wu, Ruihong, Lv, Juan, Chi, Xiumei, Wang, Xiaomei, Tu, ZhengKun, Zhong, Jin, Sun, Bing, Liu, Yang, Jiang, Jing, Niu, Junqi. CD24 Ala57Val polymorphism is associated with spontaneous viral clearance in the HCV-infected Chinese population. LIVER INTERNATIONAL[J]. 2015, 35(3): 786-794, https://www.webofscience.com/wos/woscc/full-record/WOS:000349781900011.
[86] Du, Min, Liu, Jinghua, Chen, Xia, Xie, Yadong, Yuan, Chuanping, Xiang, Yu, Sun, Bing, Lan, Ke, Chen, Mingzhou, James, Sharmy J, Zhang, Yongliang, Zhong, Jin, Xiao, Hui. Casein Kinase II Controls TBK1/IRF3 Activation in IFN Response against Viral Infection. JOURNAL OF IMMUNOLOGY[J]. 2015, 194(9): 4477-4488, https://www.webofscience.com/wos/woscc/full-record/WOS:000353727400046.
[87] Li, Dapeng, Huang, Zhong, Zhong, Jin. Hepatitis C virus vaccine development: old challenges and new opportunities. NATIONAL SCIENCE REVIEW[J]. 2015, 2(3): 285-295, http://lib.cqvip.com/Qikan/Article/Detail?id=78658382504849534851484952.
[88] Shi, Xiaodong, Chi, Xiumei, Pan, Yu, Gao, Yanhang, Li, Wanyu, Yang, Chen, Zhong, Jin, Xu, Damo, Zhang, Manna, Minuk, Gerald, Jiang, Jing, Niu, Junqi. IL28B Is Associated with Outcomes of Chronic HBV Infection. YONSEI MEDICAL JOURNAL[J]. 2015, 56(3): 625-633, http://dx.doi.org/10.3349/ymj.2015.56.3.625.
[89] Wu, Ruihong, Chi, Xiumei, Sun, Haibo, Lv, Juan, Wang, Xiaomei, Gao, Xiuzhu, Yu, Ge, Kong, Fei, Zhang, Peng, Wang, MoLi, Wang, Dongsheng, Jiang, Tao, Xu, Hongqin, Hua, Rui, Minuk, Gerald Y, Jiang, Jing, Sun, Bing, Zhong, Jin, Pan, Yu, Niu, Junqi. IFNL4 ss469415590 Polymorphism Contributes to Treatment Decisions in Patients with Chronic Hepatitis C virus Genotype 1b but not 2a Infection. HEPATOLOGYnull. 2015, 62: 776A-776A, https://www.webofscience.com/wos/woscc/full-record/WOS:000368375402471.
[90] Xu, Hongqin, Yu, Ge, Sun, Haibo, Lv, Juan, Wang, Moli, Kong, Fei, Zhang, Mingyuan, Chi, Xiumei, Wang, Xiaomei, Wu, Ruihong, Gao, Xiuzhu, Zhong, Jin, Sun, Bing, Jiang, Jing, Pan, Yu, Niu, Junqi. Use of parenteral caffeinum natrio-benzoicum: an underestimated risk factor for HCV transmission in China. BMC PUBLIC HEALTH[J]. 2015, 15: https://www.webofscience.com/wos/woscc/full-record/WOS:000361442800009.
[91] Yu, Ge, Chi, Xiumei, Wu, Ruihong, Wang, Xiaomei, Gao, Xiuzhu, Kong, Fei, Feng, Xiangwei, Gao, Yuanda, Huang, Xinxing, Jin, Jinglan, Qi, Yue, Tu, Zhengkun, Sun, Bing, Zhong, Jin, Pan, Yu, Niu, Junqi. Replication Inhibition of Hepatitis B Virus and Hepatitis C Virus in Co-Infected Patients in Chinese Population. PLOS ONE[J]. 2015, 10(9): https://www.webofscience.com/wos/woscc/full-record/WOS:000362175700061.
[92] Xiang, Yu, Tang, JingJie, Tao, Wanyin, Cao, Xuezhi, Song, BaoLiang, Zhong, Jin. Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection. JOURNAL OF VIROLOGY[J]. 2015, 89(13): 6805-6816, https://www.webofscience.com/wos/woscc/full-record/WOS:000355593000024.
[93] Cao, Xuezhi, Ding, Qiang, Lu, Jie, Tao, Wanyin, Huang, Bing, Zhao, Yanan, Niu, Junqi, Liu, YongJun, Zhong, Jin. MDA5 plays a critical role in interferon response during hepatitis C virus infection. JOURNAL OF HEPATOLOGY[J]. 2015, 62(4): 771-778, http://dx.doi.org/10.1016/j.jhep.2014.11.007.
[94] 钟劲, 陶万银. 直接抗病毒药物时代下丙型肝炎研究面临的挑战. 临床肝胆病杂志[J]. 2014, 30(6): 481-484, http://lib.cqvip.com/Qikan/Article/Detail?id=50238214.
[95] Xiao, Hui, Du, Min, Liu, Jinhua, Chen, Xia, Zhong, Jin, Xiang, Yu. Casine kinase II is a novel regulator of TBK1/IRF3 and type I interferon induction by various innate receptors. CYTOKINEnull. 2014, 70(1): 76-77, https://www.webofscience.com/wos/woscc/full-record/WOS:000343021700231.
[96] Zhong Jing. A novel strategy to develop robust infectious hepatitis C virus cell culture system directly from a clinical isolate.. J. Virology. 2014, [97] Hui Xiao, Min Du, Jinhua Liu, Xia Chen, Jin Zhong, Yu Xiang. 201: Casine kinase II is a novel regulator of TBK1/IRF3 and type I interferon induction by various innate receptors. Cytokine. 2014, 70(1): 76-77, http://dx.doi.org/10.1016/j.cyto.2014.07.208.
[98] Chen, Wei, Xu, Yongfen, Li, Hua, Tao, Wanyin, Xiang, Yu, Huang, Bing, Niu, Junqi, Zhong, Jin, Meng, Guangxun. HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells. PLOS ONE[J]. 2014, 9(1): https://doaj.org/article/4d263f5c99854e5999c11cfdcc85f5b0.
[99] Sha, Wenwen, Mitoma, Hiroki, Hanabuchi, Shino, Bao, Musheng, Weng, Leiyun, Sugimoto, Naoshi, Liu, Ying, Zhang, Zhiqiang, Zhong, Jin, Sun, Bing, Liu, YongJun. Human NLRP3 inflammasome senses multiple types of bacterial RNAs. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 111(45): 16059-16064, https://www.webofscience.com/wos/woscc/full-record/WOS:000344526800054.
[100] Zhong Jing. MDA5 Plays a Critical Role in Interferon Response during Hepatitis C Virus Infection.. J. Hepatology.. 2014, [101] Zhao, Yinglan, Ren, Yushan, Zhang, Xuping, Zhao, Ping, Tao, Wanyin, Zhong, Jin, Li, Qiao, Zhang, XiaoLian. Ficolin-2 Inhibits Hepatitis C Virus Infection, whereas Apolipoprotein E3 Mediates Viral Immune Escape. JOURNAL OF IMMUNOLOGY[J]. 2014, 193(2): 783-796, https://www.webofscience.com/wos/woscc/full-record/WOS:000338958300035.
[102] Hu, Xiaoli, Jiang, Yanfang, Li, Xiurong, Gao, Yanhang, Guo, Xiaoli, Chi, Xiumei, Yan, Hongqing, Feng, Junyan, Zhong, Jin, Sun, Bing, Shao, Xue, Xiao, Weihua, Pan, Yu, Niu, Junqi. Long-Term Effect on Natural Killer Cells by Interferon-alpha Therapy on the Outcomes of HCV Infection. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH[J]. 2014, 34(5): 366-375, https://www.webofscience.com/wos/woscc/full-record/WOS:000336504000007.
[103] Zhong Jing. DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus.. Virology. 2013, [104] Kang, Xi, Chen, Xi, He, Ying, Guo, Deyin, Guo, Lin, Zhong, Jin, Shu, HongBing. DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication. VIROLOGY[J]. 2013, 435(2): 385-394, http://dx.doi.org/10.1016/j.virol.2012.10.025.
[105] Qi, Yue, Xiang, Yu, Wang, Juan, Qi, Yanfei, Li, Juan, Niu, Junqi, Zhong, Jin. Inhibition of hepatitis C virus infection by polyoxometalates. ANTIVIRAL RESEARCH[J]. 2013, 100(2): 392-398, http://dx.doi.org/10.1016/j.antiviral.2013.08.025.
[106] Ding, Qiang, Cao, Xuezhi, Lu, Jie, Huang, Bing, Liu, YongJun, Kato, Nobuyuki, Shu, HongBing, Zhong, Jin. Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity. JOURNAL OF HEPATOLOGY[J]. 2013, 59(1): 52-58, http://dx.doi.org/10.1016/j.jhep.2013.03.019.
[107] Shan, Zhao, Han, Qinglin, Nie, Jia, Cao, Xuezhi, Chen, Zuojia, Yin, Shuying, Gao, Yayi, Lin, Fang, Zhou, Xiaohui, Xu, Ke, Fan, Huimin, Qian, Zhikang, Sun, Bing, Zhong, Jin, Li, Bin, Tsun, Andy. Negative Regulation of Interferon-induced Transmembrane Protein 3 by SET7-mediated Lysine Monomethylation. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2013, 288(49): 35093-35103, http://dx.doi.org/10.1074/jbc.M113.511949.
[108] Lu, Jie, Tao, Wanyin, Li, Rui, Xiang, Yu, Zhang, Nan, Xiang, Xiaogang, Xie, Qing, Zhong, Jin. Construction and characterization of infectious hepatitis C virus chimera containing structural proteins directly from genotype 1b clinical isolates. VIROLOGY[J]. 2013, 443(1): 80-88, http://dx.doi.org/10.1016/j.virol.2013.04.030.
[109] Meng Guangxun. HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells.. PLOS ONE. 2013, [110] Xu, Yongfen, Li, Hua, Chen, Wei, Yao, Xiaomin, Xing, Yue, Wang, Xun, Zhong, Jin, Meng, Guangxun. Mycoplasma hyorhinis Activates the NLRP3 Inflammasome and Promotes Migration and Invasion of Gastric Cancer Cells. PLOS ONE[J]. 2013, 8(11): https://doaj.org/article/ef11198478194558ad78a4bd5d884fe0.
[111] Ying He, Leiyun Weng, Rui Li, Li Li, Tetsuya Toyoda, Jin Zhong. The N-terminal helix α0 of hepatitis C virus NS3 protein dictates the subcellular localization and stability of NS3/NS4A complex. Virology. 2012, 422(2): 214-223, http://dx.doi.org/10.1016/j.virol.2011.10.021.
[112] Shi, Xiaodong, Pan, Yu, Wang, Moli, Wang, Dongsheng, Li, Wanyu, Jiang, Tao, Zhang, Peng, Chi, Xiumei, Jiang, Yanfang, Gao, Yanhang, Zhong, Jin, Sun, Bing, Xu, Damo, Jiang, Jing, Niu, Junqi. IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population. PLOS ONE[J]. 2012, 7(5): http://dx.doi.org/10.1371/journal.pone.0037054.
[113] He, Ying, Weng, Leiyun, Li, Rui, Li, Li, Toyoda, Tetsuya, Zhong, Jin. The N-terminal helix alpha(0) of hepatitis C virus NS3 protein dictates the subcellular localization and stability of NS3/NS4A complex. VIROLOGY[J]. 2012, 422(2): 214-223, https://www.webofscience.com/wos/woscc/full-record/WOS:000299755900007.
[114] Ding, Qiang, Huang, Bing, Lu, Jie, Liu, YongJun, Zhong, Jin. Hepatitis C virus NS3/4A protease blocks IL-28 production. EUROPEAN JOURNAL OF IMMUNOLOGY[J]. 2012, 42(9): 2374-2382, https://www.webofscience.com/wos/woscc/full-record/WOS:000308404800020.
[115] 陶万银, 张岩, 钟劲. HCV实验动物模型研究进展. 传染病信息[J]. 2012, 25(2): 71-74, http://lib.cqvip.com/Qikan/Article/Detail?id=41823628.
[116] Xiang, Xiaogang, Lu, Jie, Dong, Zhixia, Zhou, Huijuan, Tao, Wanyin, Guo, Qing, Zhou, Xiaqiu, Bao, Shisan, Xie, Qing, Zhong, Jin. Viral sequence evolution in Chinese genotype 1b chronic hepatitis C patients experiencing unsuccessful interferon treatment. INFECTION GENETICS AND EVOLUTION[J]. 2011, 11(2): 382-390, http://dx.doi.org/10.1016/j.meegid.2010.11.011.
[117] Li, Rui, Qin, Yan, He, Ying, Tao, Wanyin, Zhang, Nan, Tsai, Cheguo, Zhou, Paul, Zhong, Jin. Production of Hepatitis C Virus Lacking the Envelope-Encoding Genes for Single-Cycle Infection by Providing Homologous Envelope Proteins or Vesicular Stomatitis Virus Glycoproteins in trans. JOURNAL OF VIROLOGY[J]. 2011, 85(5): 2138-2147, https://www.webofscience.com/wos/woscc/full-record/WOS:000286974900020.
[118] Chen, Fang, Zhao, Yinglan, Liu, Min, Li, Dongqing, Wu, Hongyan, Chen, Haidan, Zhu, Yongzhe, Luo, Fengling, Zhong, Jin, Zhou, Yidan, Qi, Zhongtian, Zhang, XiaoLian. Functional Selection of Hepatitis C Virus Envelope E2-Binding Peptide Ligands by Using Ribosome Display. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY[J]. 2010, 54(8): 3355-3364, http://dx.doi.org/10.1128/AAC.01357-09.
[119] Weng, Leiyun, Hirata, Yuichi, Arai, Masaaki, Kohara, Michinori, Wakita, Takaji, Watashi, Koichi, Shimotohno, Kunitada, He, Ying, Zhong, Jin, Toyoda, Tetsuya. Sphingomyelin Activates Hepatitis C Virus RNA Polymerase in a Genotype-Specific Manner. JOURNAL OF VIROLOGY[J]. 2010, 84(22): 11761-11770, https://www.webofscience.com/wos/woscc/full-record/WOS:000283420500015.
[120] Tao, Wanyin, Xu, Chunliang, Ding, Qiang, Li, Rui, Xiang, Yu, Chung, Josan, Zhong, Jin. A single point mutation in E2 enhances hepatitis C virus infectivity and alters lipoprotein association of viral particles. VIROLOGY[J]. 2009, 395(1): 67-76, http://dx.doi.org/10.1016/j.virol.2009.09.006.
[121] 钟劲. 丙型肝炎病毒实验模型和分子病毒学的研究进展. 中华肝脏病杂志[J]. 2009, 17(7): 494-496, http://lib.cqvip.com/Qikan/Article/Detail?id=30970161.
[122] Deng, Weiwen, Shi, Mude, Han, Meifang, Zhong, Jin, Li, Zhenhu, Li, Weina, Hu, Yu, Yan, Lingchen, Wang, Jie, He, Ying, Tang, Hong, Deubel, Vincent, Luo, Xiaoping, Ning, Qin, Sun, Bing. Negative Regulation of Virus-triggered IFN-beta Signaling Pathway by Alternative Splicing of TBK1. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2008, 283(51): 35590-35597, http://www.irgrid.ac.cn/handle/1471x/757651.
[123] Oem, JaeKu, JackelCram, Candice, Li, YiPing, Zhou, Yan, Zhong, Jin, Shimano, Hitoshi, Babiuk, Lorne A, Liu, Qiang. Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2. JOURNAL OF GENERAL VIROLOGY[J]. 2008, 89: 1225-1230, https://www.webofscience.com/wos/woscc/full-record/WOS:000255698900016.
[124] Weiwen Deng, Mude Shi, Meifang Han, Jin Zhong, Zhenhu Li, Weina Li, Yu Hu, Lingchen Yan, Jie Wang, Ying He, Hong Tang, Vincent Deubel, Xiaoping Luo, Qin Ning, Bing Sun. Negative Regulation of Virus-triggered IFN-β Signaling Pathway by Alternative Splicing of TBK1. Journal of Biological Chemistry. 2008, 283(51): 35590-35597, http://dx.doi.org/10.1074/jbc.M805775200.
[125] Grove, Joe, Nielsen, Soren, Zhong, Jin, Bassendine, Margaret F, Drummer, Heidi E, Balfe, Peter, McKeating, Jane A. Identification of a Residue in Hepatitis C Virus E2 Glycoprotein That Determines Scavenger Receptor BI and CD81 Receptor Dependency and Sensitivity to Neutralizing Antibodies. JOURNAL OF VIROLOGY[J]. 2008, 82(24): 12020-12029, https://www.webofscience.com/wos/woscc/full-record/WOS:000261164000004.
[126] Cheng, Guofeng, Zhong, Jin, Chung, Josan, Chisari, Francis V. Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2007, 104(21): 9035-9040, https://www.webofscience.com/wos/woscc/full-record/WOS:000246853700064.
[127] Zhong Jing. The Recent Progress on Experimental Models and Molecular Virology of Hepatitis C Virus.. Chin. J. Hepatol.. 2007, [128] Zhong Jing. Persistent HCV infection in vitro: co-evolution of virus and host.. J.Virol.. 2006, [129] Zhong Jing. Inhibition of Double-Stranded RNA- Induced Signaling in Hepatitis C Virus-Infected Cells by NS3 Protease-Dependent and -Independent Mechanisms.. Proc. Natl. Acad. Sci. U. S. A.. 2006, [130] Zhong, J, Gastaminza, P, Cheng, GF, Kapadia, S, Kato, T, Burton, DR, Wieland, SF, Uprichard, SL, Wakita, T, Chisari, FV. Robust hepatitis C virus infection in vitro. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2005, 102(26): 9294-9299, https://www.webofscience.com/wos/woscc/full-record/WOS:000230191400038.

科研活动

   
科研项目
( 1 ) 丙型肝炎病毒感染及防治的基础研究, 主持, 国家级, 2009-01--2013-08
( 2 ) Subversion of the IFN signaling pathway by HCV: ROLE OF THE VIRUS CORE PROTEIN AS IFN ANTAGONIST DUE TO ITS INTERACTION WITH MICROTUBULE NETWORK., 主持, 研究所(学校), 2010-01--2011-12
( 3 ) 基于反式互补的新型丙型肝炎病毒细胞感染模型的建立及其在丙肝研究中的应用, 主持, 国家级, 2012-01--2015-12
( 4 ) 难治性丙肝转归预测预警的研究, 主持, 国家级, 2012-01--2015-12
( 5 ) NS3蛋白N末端α螺旋结构参与HCV病毒颗粒组装的机制研究, 主持, 国家级, 2013-01--2016-12
( 6 ) 丙型肝炎病毒诱导和逃逸宿主细胞干扰素信号通路的机制研究, 主持, 国家级, 2014-01--2018-12
( 7 ) 慢性丙型病毒性肝炎免疫逃逸与免疫病理研究, 主持, 国家级, 2015-01--2019-08
( 8 ) 难治性丙型肝炎生物学特性及其创新治疗方案的前期研究, 主持, 国家级, 2008-01--2011-12
参与会议
(1)Development and application of a novel Ebola virus replicon model that stably replicates a viral mini-genome.   2016-04-13
(2)How hepatocytes sense HCV infection to induce innate immunity.   2016-01-22
(3)The old and new challenges in the translational and basic HCV research.   2016-01-08
(4)Hepatitis C Virus and Host Innate Immunity.   2015-10-19
(5)Hepatitis C virus and host interferon responses.   2015-05-13
(6)Hepatitis C virus and host interferon responses.   2015-05-13

指导学生

已指导学生

何莹  01  19178  

陶万银  01  19178  

李瑞  01  19178  

卢捷  01  19178  

丁强  01  19178  

曹学智  01  19178  

向禹  01  19178  

现指导学生

于涛  01  19178  

颜雨  01  19178  

黑蕾  01  19178  

梁轶莎  02  19178  

叶丽清  02  19178  

李庆超  01  19178  

何振亮  01  19178  

王雪松  01  19178  

韩林  02  19182  

郭明哲  01  19178  

赵亚楠  01  19178  

杨乾坤  01  19178  

甘天喻  01  19178