基本信息
王江云 男 博导 生物物理研究所
电子邮件:jwang@sun5.ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码: 100101

研究领域

        王江云研究员,国家杰出青年基金获得者,国家万人计划青年拔尖人才,于2007年获中国科学院****资助到中国科学院生物物理研究所工作,组建了以研究生物物理化学、合成生物学及化学生物学为主要方向的课题组。主要研究内容包括:1. 发展蛋白质及RNA标记的新方法,研究蛋白质及RNA的定位,结构,折叠,以及相互作用。2. 研究含有金属卟啉和铜离子的蛋白质的结构功能,并在此基础上设计新的金属酶。 
      

招生信息

招生专业:
生物物理学;生物化学与分子生物学;细胞生物学;合成生物学;化学生物学

教育背景

1998-09--2003-07 Univ. of Illinois at Urbana Champaign 化学博士
1994-09--1998-07 中国科技大学少年班零零班 化学物理学士

工作经历

   
工作简历
2007-09--今 生物物理所结构生物学与分子生物学研究中心 研究员
2003-07--2007-09 Scripps 研究所 博士后

教授课程

生物物理学系列讲座

专利与奖励

   
奖励信息
(1) 亚洲光化学学会青年科学家奖,其他级,2014
(2) 中国科学院****终期评估优秀,院级级,2013
(3) 第十三届中国青年科技奖,其他级,2013
(4) 国家杰出青年基金,专项级,2013
专利成果
[1] 王江云, 刘晓红, 康福英, 胡诚, 汪莉, 许震. 一种可基因编码的人工光合作用蛋白质及其应用. CN: CN110964088B, 2021-07-13.

[2] 王江云, 刘晓红, 姜丽, 江欢欢. 酪氨酸类似物翻译系统和基因编码的蛋白质光致电子转移荧光传感器蛋白家族. CN: CN109295025B, 2021-04-02.

[3] 王江云, 刘晓红, 李家松, 胡诚, 周庆, 张维, 胡美荣, 周娟作, 江欢欢. 8-羟基喹啉丙氨酸翻译系统及其应用. CN: CN106047846B, 2020-02-04.

[4] 王江云, 夏霖, 韩明杰, 杨朝雅. 使用新型电化学传感器的氨基酸特异实时检测方法. CN: CN110568039A, 2019-12-13.

[5] 王江云, 安晓景, 王天元, 韩明杰, 黄爱萍, 陈超, 江欢欢. 硒代酪氨酸翻译系统及其应用. CN: CN110117580A, 2019-08-13.

[6] 王江云, 李发慧. 一种细胞内位点特异性共价标记RNA的新方法. CN: CN105985944B, 2019-05-28.

[7] 王江云, 刘晓红, 姜丽, 江欢欢. 酪氨酸类似物翻译系统和基因编码的蛋白质光致电子转移荧光传感器蛋白家族. 中国: CN105420203A, 2016-03-23.

[8] 王江云, 刘晓红, 李家松, 胡诚, 周庆, 张维, 胡美荣, 周娟作, 江欢欢. 8-羟基喹啉丙氨酸翻译系统及其应用. 中国: CN104059891A, 2014-09-24.

[9] 王江云, 李发慧, 李家松, 龚为民, 江欢欢. 3,5-二氟代酪氨酸翻译系统及其应用. 中国: CN104004723A, 2014-08-27.

[10] 王江云, 周庆, 胡美荣, 张维, 姜丽, 柯莎, 周娟作, 江欢欢. 3-甲硫酪氨酸翻译系统及其应用. 中国: CN103820410A, 2014-05-28.

[11] 王江云, 潘延超, 江欢欢, 高峰. N ε -(1-甲基环丙-2-烯酰胺)-赖氨酸翻译系统及其应用. 中国: CN103667202A, 2014-03-26.

[12] 王江云, 刘晓红, 李家松, 董建树, 胡诚, 龚为民, 江欢欢. 3-吡唑基酪氨酸翻译系统及其应用. 中国: CN103571804A, 2014-02-12.

[13] 王江云, 李发慧, 孙云, 潘延超. 丙烯酰赖氨酸翻译系统及其应用. 中国: CN102925427A, 2013.02.13.

[14] 王江云, 刘晓红, 胡诚, 江欢欢. 3-咪唑基酪氨酸翻译系统及其应用. 中国: CN103215235A, 2013-07-24.

[15] 王江云, 张维, 江欢欢. 3-氯代酪氨酸翻译系统及其应用. 中国: CN102888387A, 2013-01-23.

出版信息

   
发表论文
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[5] Dandan Zheng, Min Tao, Longjiang Yu, Xiaohong Liu, Andong Xia, Jiangyun Wang. Ultrafast photo-induced electron transfer in a photosensitizer protein. CCS Chemistry[J]. 2021, 3: 1580-1586, [6] Cheng, Ronghai, Lai, Rui, Peng, Chao, Lopez, Juan, Li, Zhihong, Naowarojna, Nathchar, Li, Kelin, Wong, Christina, Lee, Norman, Whelan, Stephen A, Qiao, Lu, Grinstaff, Mark W, Wang, Jiangyun, Cui, Qiang, Liu, Pinghua. Implications for an Imidazole-2-yl Carbene Intermediate in the Rhodanase-Catalyzed C-S Bond Formation Reaction of Anaerobic Ergothioneine Biosynthesis. ACS CATALYSIS[J]. 2021, 11(6): 3319-3334, http://dx.doi.org/10.1021/acscatal.0c04886.
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[8] QingTao He, Peng Xiao, ShenMing Huang, YingLi Jia, ZhongLiang Zhu, JingYu Lin, Fan Yang, XiaoNa Tao, RuJia Zhao, FengYuan Gao, XiaoGang Niu, KunHong Xiao, Jiangyun Wang, Changwen Jin, JinPeng Sun, Xiao Yu. Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. NATURE COMMUNICATIONS[J]. 2021, 12(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062632/.
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[15] Zheng, Dandan, Zhang, Ying, Liu, Xiaohong, Wang, Jiangyun. Coupling natural systems with synthetic chemistry for light-driven enzymatic biocatalysis. PHOTOSYNTHESIS RESEARCH[J]. 2020, 143(2): 221-231, https://www.webofscience.com/wos/woscc/full-record/WOS:000512061800011.
[16] Qi Liu, Qingtao He, Xiaoxuan Lyu, Fan Yang, Zhongliang Zhu, Peng Xiao, Zhao Yang, Feng Zhang, Zhaoya Yang, Xiaoyan Wang, Peng Sun, Qianwen Wang, Changxiu Qu, Zheng Gong, Jingyu Lin, Zhen Xu, Shaole Song, Shenming Huang, Shengchao Guo, Mingjie Han, Kongkai Zhu, Xin Chen, Alem W Kahsai, KunHong Xiao, Wei Kong, Fahui Li, Ke Ruan, Zijian Li, Xiao Yu, Xiaogang Niu, Changwen Jin, Jiangyun Wang, Jinpeng Sun. DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe. Nature Communications[J]. 2020, 11(1): 1-17, http://dx.doi.org/10.1038/s41467-020-18433-5.
[17] Zheng, Zhaopeng, Guo, Xuzhen, Yu, Minling, Wang, Xiaoyan, Lu, Hongguang, Li, Fahui, Wang, Jiangyun. Identification of Human IDO1 Enzyme Activity by Using Genetically Encoded Nitrotyrosine. CHEMBIOCHEM[J]. 2020, 21(11): 1593-1596, https://www.webofscience.com/wos/woscc/full-record/WOS:000516656300001.
[18] Lin, Zhanglin, Zhao, Qing, Wang, Xu, Zhou, Bihong, Xing, Lei, Wang, Jiangyun, Pistolozzi, Marco, Zhao, Lei, Wang, Tingting. Engineered pH-inducible intein Mtu Delta I-CM variants with markedly reduced premature cleavage activity. AICHE JOURNAL[J]. 2020, 66(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000489145000001.
[19] Yu, Yang, Liu, Xiaohong, Wang, Jiangyun. Expansion of Redox Chemistry in Designer Metalloenzymes. ACCOUNTS OF CHEMICAL RESEARCHnull. 2019, 52(3): 557-565, https://www.webofscience.com/wos/woscc/full-record/WOS:000462098100005.
[20] Chen, Li, Naowarojna, Nathchar, Chen, Bin, Xu, Meiling, Quill, Melissa, Wang, Jiangyun, Deng, Zixin, Zhao, Changming, Liu, Pinghua. Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr). ACS CATALYSIS[J]. 2019, 9(1): 253-258, [21] Wang, Jiangyun. Genetically encoded photosensitizer protein facilitates the rational design of a miniature photocatalytic CO2 reducing enzyme. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETYnull. 2019, 258: [22] Li, Kangshuai, Hou, Xuben, Li, Ruirui, Bi, Wenxiang, Yang, Fan, Chen, Xu, Xiao, Peng, Liu, Tiantian, Lu, Tiange, Zhou, Yuan, Tian, Zhaomei, Shen, Yuemao, Zhang, Yingkai, Wang, Jiangyun, Fang, Hao, Sun, Jinpeng, Yu, Xiao. Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(21): 8653-8663, http://dx.doi.org/10.1074/jbc.RA118.007129.
[23] Xia, Lin, Han, MingJie, Zhou, Lu, Huang, Aiping, Yang, Zhaoya, Wang, Tianyuan, Li, Fahui, Yu, Lu, Tian, Changlin, Zang, Zhongsheng, Yang, QingZheng, Liu, Chenli, Hong, Wenxu, Lu, Yi, Alfonta, Lital, Wang, Jiangyun. S-Click Reaction for Isotropic Orientation of Oxidases on Electrodes to Promote Electron Transfer at Low Potentials. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(46): 16480-16484, [24] Huang, ShenMing, Yang, Fan, Cai, BaiYang, He, QngTao, Liu, Qi, Qu, ChangXiu, Han, MingJie, Kong, Wei, Jia, YingLi, Li, Fahui, Yu, Xiao, Sun, JinPeng, Wang, Jiangyun. Genetically Encoded Fluorescent Amino Acid for Monitoring Protein Interactions through FRET. ANALYTICAL CHEMISTRY[J]. 2019, 91(23): 14936-14942, https://www.webofscience.com/wos/woscc/full-record/WOS:000500838600025.
[25] Yu, Yang, Hu, Cheng, Xia, Lin, Wang, Jiangyun. Artificial Metalloenzyme Design with Unnatural Amino Acids and Non-Native Cofactors. ACS CATALYSISnull. 2018, 8(3): 1851-1863, http://ir.siat.ac.cn:8080/handle/172644/13420.
[26] Mu, Zepeng, Zou, Zhuoning, Yang, Ye, Wang, Wenbo, Xu, Yue, Huang, Jianyi, Cai, Ruiling, Liu, Ye, Mo, Yajin, Wang, Boyi, Dang, Yiqun, Li, Yongming, Liu, Yushan, Jiang, Yueren, Tan, Qingyang, Liu, Xiaohong, Hu, Cheng, Li, Hua, Wei, Sha, Lou, Chunbo, Yu, Yang, Wang, Jiangyun. A genetically engineered Escherichia coli that senses and degrades tetracycline antibiotic residue. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2018, 3(3): 196-203, http://lib.cqvip.com/Qikan/Article/Detail?id=7103844762.
[27] Zhang, Jia, Wang, Li, Zhang, Jin, Zhu, Jiangrui, Pan, Xin, Cui, Zhifeng, Wang, Jiangyun, Fang, Weihai, Li, Yunliang. Identifying and Modulating Accidental Fermi Resonance: 2D IR and DFT Study of 4-Azido-L-phenylalanine. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2018, 122(34): 8122-8133, https://www.webofscience.com/wos/woscc/full-record/WOS:000443922600002.
[28] Wang Li, Chen Xian, Guo Xuzhen, Li Jiasong, Liu Qi, Kang Fuying, Wang Xudong, Hu Cheng, Liu Haiping, Gong Weimin, Zhuang Wei, Liu Xiaohong, Wang Jiangyun. Significant expansion and red-shifting of fluorescent protein chromophore determined through computational design and genetic code expansion. Biophysics Reports[J]. 2018, 4(5): 273-285, [29] Liu, Xiaohong, Kang, Fuying, Hu, Cheng, Wang, Li, Xu, Zhen, Zheng, Dandan, Gong, Weimin, Lu, Yi, Ma, Yanhe, Wang, Jiangyun. A genetically encoded photosensitizer protein facilitates the rational design of a miniature photocatalytic CO2-reducing enzyme. NATURE CHEMISTRY[J]. 2018, 10(12): 1201-1206, https://www.webofscience.com/wos/woscc/full-record/WOS:000450790300008.
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[57] Bi, Kelei, Zheng, Yueting, Gao, Feng, Dong, Jianshu, Wang, Jiangyun, Wang, Yi, Gong, Weimin. Crystal structure of E-coli arginyl-tRNA synthetase and ligand binding studies revealed key residues in arginine recognition. PROTEIN & CELL[J]. 2014, 5(2): 151-159, https://www.webofscience.com/wos/woscc/full-record/WOS:000333172500007.
[58] Hu, Cheng, Chan, Sunney I, Sawyer, Elizabeth B, Yu, Yang, Wang, Jiangyun. Metalloprotein design using genetic code expansion. CHEMICAL SOCIETY REVIEWSnull. 2014, 43(18): 6498-6510, http://124.16.173.210/handle/834782/2269.
[59] Lin YingWu, Wang JiangYun, Lu Yi. Functional tuning and expanding of myoglobin by rational protein design. SCIENCE CHINA-CHEMISTRYnull. 2014, 57(3): 346-355, https://www.webofscience.com/wos/woscc/full-record/WOS:000331980000002.
[60] 林英武, 王江云, 陆艺. 蛋白质分子理性设计与肌红蛋白功能的调控及拓展. 中国科学. 化学[J]. 2014, 44(4): 654-654, [61] Pan, Yanchao, Jin, JingHua, Yu, Yang, Wang, Jiangyun. Significant Enhancement of hPrx1 Chaperone Activity through Lysine Acetylation. CHEMBIOCHEM[J]. 2014, 15(12): 1773-1776, http://124.16.173.210/handle/834782/2270.
[62] Zheng, Yueting, Lv, Xiaoxuan, Wang, Jiangyun. A genetically encoded sulfotyrosine for VHR function research. PROTEIN & CELLnull. 2013, 4(10): 731-734, https://www.webofscience.com/wos/woscc/full-record/WOS:000325432000003.
[63] Jiangyun Wang. A Genetically Encoded 19F NMR Sensor for Tyrosine Phosphorylation. Angew. Chem. Int. Ed. 2013, [64] Liu, Xiaohong, Li, Jiasong, Hu, Cheng, Zhou, Qing, Zhang, Wei, Hu, Meirong, Zhou, Juanzuo, Wang, Jiangyun. Significant Expansion of the Fluorescent Protein Chromophore through the Genetic Incorporation of a Metal-Chelating Unnatural Amino Acid. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2013, 52(18): 4805-4809, http://www.irgrid.ac.cn/handle/1471x/756537.
[65] Lin, YingWu, Sawyer, Elizabeth B, Wang, Jiangyun. Rational Heme Protein Design: All Roads Lead to Rome. CHEMISTRY-AN ASIAN JOURNALnull. 2013, 8(11): 2534-2544, https://www.webofscience.com/wos/woscc/full-record/WOS:000326292200006.
[66] Xu, Xinyi, Hu, Xiaosong, Wang, Jiangyun. A new synthetic protocol for coumarin amino acid. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY[J]. 2013, 9(1): 254-259, http://www.irgrid.ac.cn/handle/1471x/756522.
[67] Jiangyun Wang. Significant Expansion of the Fluorescent Protein Chromophore through the Genetic Incorporation of an Unnatural Amino Acid.. 2013, [68] Pan, Chang, Liu, HongDa, Gong, Zheng, Yu, Xiao, Hou, XuBen, Xie, DiDong, Zhu, XiBin, Li, HaoWen, Tang, JunYi, Xu, YunFei, Yu, JiaQi, Zhang, LianYing, Fang, Hao, Xiao, KunHong, Chen, YuGuo, Wang, JiangYun, Pang, Qi, Chen, Wei, Sun, JinPeng. Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site. SCIENTIFIC REPORTS[J]. 2013, 3: http://www.irgrid.ac.cn/handle/1471x/756580.
[69] Wang, Jiangyun. Metalloprotein design through the genetic incorporation of unnatural amino acids. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETYnull. 2013, 246: https://www.webofscience.com/wos/woscc/full-record/WOS:000329618404511.
[70] Zhou, Qing, Hu, Meirong, Zhang, Wei, Jiang, Li, Perrett, Sarah, Zhou, Juanzuo, Wang, Jiangyun. Probing the Function of the Tyr-Cys Cross-Link in Metalloenzymes by the Genetic Incorporation of 3-Methylthiotyrosine. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2013, 52(4): 1203-1207, http://www.irgrid.ac.cn/handle/1471x/756556.
[71] Jiangyun Wang. Probing the Function of the Tyr-Cys Crosslink in Metalloenzymes through the Genetic Incorporation of 3-Methylthiotyrosine. Angew. Chem. Intl. Ed. 2013, [72] 朱晓璐, 王江云. 地磁场与生物的磁感应现象. 自然杂志. 2013, 35(3): 200-206, http://lib.cqvip.com/Qikan/Article/Detail?id=46273745.
[73] 杨福愉. A Genetically Encoded F-19 NMR Probe for Tyrosine Phosphorylation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2013, 52(14): 3958-3962, http://www.irgrid.ac.cn/handle/1471x/756611.
[74] Li, Fahui, Zhang, Hua, Sun, Yun, Pan, Yanchao, Zhou, Juanzuo, Wang, Jiangyun. Expanding the Genetic Code for Photoclick Chemistry in E.coli, Mammalian Cells, and A.thaliana. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2013, 52(37): 9700-9704, https://www.webofscience.com/wos/woscc/full-record/WOS:000323829600021.
[75] Lin, YingWu, Wang, Jiangyun. Structure and function of heme proteins in non-native states: A mini-review. JOURNAL OF INORGANIC BIOCHEMISTRYnull. 2013, 129: 162-171, http://dx.doi.org/10.1016/j.jinorgbio.2013.07.023.
[76] Liu, Xiaohong, Yu, Yang, Hu, Cheng, Zhang, Wei, Lu, Yi, Wang, Jiangyun. Significant Increase of Oxidase Activity through the Genetic Incorporation of a Tyrosine-Histidine Cross-Link in a Myoglobin Model of Heme-Copper Oxidase. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2012, 51(18): 4312-4316, http://www.irgrid.ac.cn/handle/1471x/756920.
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科研活动

   
科研项目
(1) 表观遗传信息建立与解读的分子基础,参与,国家级,2015-01--2016-12
(2) 基因信息传递过程中非编码RNA的调控作用机制,主持,国家级,2015-01--2017-12
(3) 化学生物学,主持,国家级,2014-01--2017-12
(4) 基于化学小分子探针的信号转导过程研究,参与,国家级,2014-01--2015-12
(5) 非编码RNA的前沿研究,主持,院级级,2013-01--2015-12
(6) 基因编码的非天然氨基酸作为探针研究细胞骨架组装分子机制,参与,国家级,2010-01--2014-08
(7) 蛋白质特异标记技术的分子生物学方法,参与,国家级,2010-01--2014-08
(8) 表观遗传学的化学生物学研究,主持,国家级,2009-01--2013-08
参与会议
(1) Functional photoactive protein synthesis using genetic code expansion,第27届光化学国际会议,2015-06,Jiangyun Wang
(2) metalloprotein design using genetic code expansion ,第七届亚洲生物无机化学会议,2014-12,Jiangyun Wang
(3) Imaging the proteome through the genetic incorporation of unnatural amino acids,第六届亚洲-大洋洲光生物学会议,2013-11,Jiangyun Wang
(4) A synthetic biology approach for metalloprotein design,第六届合成生物学国际会议,2013-07,Jiangyun Wang
(5) Synthetic chemical biology,生物物理大会,2011-10,王江云

指导学生

已指导学生

张维  博士研究生  071010-生物化学与分子生物学  

潘延超  博士研究生  071010-生物化学与分子生物学  

徐欣怡  博士研究生  071010-生物化学与分子生物学  

郑悦亭  博士研究生  071011-生物物理学  

周庆  博士研究生  071010-生物化学与分子生物学  

吕晓璇  博士研究生  071010-生物化学与分子生物学  

朱晓璐  硕士研究生  085238-生物工程  

现指导学生

胡诚  硕士研究生  071010-生物化学与分子生物学  

康福英  硕士研究生  071009-细胞生物学  

隋龙臻  博士研究生  071010-生物化学与分子生物学  

郝亚洲  硕士研究生  071009-细胞生物学  

杜康  硕士研究生  071009-细胞生物学  

王晓燕  博士研究生  071010-生物化学与分子生物学  

祝嘉骏  博士研究生  071009-细胞生物学  

张成  硕士研究生  071009-细胞生物学  

许震  硕士研究生  071010-生物化学与分子生物学  

汪莉  博士研究生  071010-生物化学与分子生物学  

中国科学院生物物理研究所个人网页链接

http://www.ibp.cas.cn/ktzz/ktzz_W/201308/t20130829_3920425.html