基本信息
金万洙 男 博导 动物研究所
电子邮件:jinw@ioz.ac.cn
通信地址:北京市朝阳区北辰西路1-5
邮政编码:100101
电子邮件:jinw@ioz.ac.cn
通信地址:北京市朝阳区北辰西路1-5
邮政编码:100101
招生信息
招生专业
071008-发育生物学
招生方向
能量代谢,发育生物学
专利与奖励
专利成果
[1] 金万洙, 叶荣财, 黄园园, 蒋瑞. 棕色脂肪细胞来源外泌体在治疗关节炎相关病症中的应用. CN: CN116602992A, 2023-08-18.[2] 金万洙, 叶荣财. 一种棕色脂肪细胞来源的外泌体及其制备方法和应用. CN: CN114517187A, 2022-05-20.[3] 金万洙, 蒋笑笑, 严春龙. 一种重组乳酸乳球菌、微胶囊及其应用. CN: CN114426942A, 2022-05-03.[4] 金万洙, 董孟, 张瀚林, 程子昱. 一种表达VEGFR3 D2多肽的细菌制剂及其构建方法和应用. CN: CN114262683A, 2022-04-01.[5] 金万洙. 一种表达VEGFR3 D2多肽的细菌制剂及其构建方法和应用. CN202210191147.8, 2022-03-01.[6] 金万洙, 林骏, 蒋笑笑. PZP的用途以及包括PZP的用于抵抗肥胖的药物组合物. CN: CN113876937A, 2022-01-04.[7] 金万洙. PPD制备预防或治疗TGFβ通路相关疾病的药物的用途. CN: CN113318117A, 2021-08-31.[8] 金万洙. 粪肠球菌的用途. CN: CN113164530A, 2021-07-23.[9] 郑爱华, 赵超越, 李虹悦, 张毓航, 金万洙, 赵建国. 基于水疱性口炎病毒载体的重组新型冠状病毒及其制备方法与应用. CN: CN112941038A, 2021-06-11.[10] 金万洙. 一种组成型乳酸菌启动子、重组载体及其重组菌和应用. CN: CN111518801B, 2021-05-28.[11] 金万洙, 张瀚林, 蒋笑笑, 郑爱华. 一种表达LL-37多肽的重组表达载体、重组乳酸乳球菌、抗病毒药物及构建方法和应用. CN: CN111500615B, 2021-05-14.[12] 金万洙. 肉豆蔻脑酸甲酯在制备预防或治疗代谢综合征或改善机体能量代谢的产品中的应用. CN: CN109999019A, 2019-07-12.[13] 赵建国, 郑千涛, 黄娇娇, 秦国嵩, 金万洙. 一种抗寒及瘦肉型转基因猪及其制备方法. CN: CN107182940A, 2017-09-22.[14] 金万洙, 袁晓雪, 黄园园. 芦丁在制备用于治疗肥胖及相关疾病的药物中的应用. CN: CN104958309A, 2015-10-07.[15] 金万洙, 刘晓萌, 黄园园. 血管紧张素转化酶抑制剂的应用. CN: CN104013962A, 2014-09-03.
出版信息
发表论文
[1] Jiang, Xiaoxiao, Yan, Chunlong, Zhang, Hanlin, Chen, Li, Jiang, Rui, Zheng, Kexin, Jin, Wanzhu, Ma, Huijuan, Liu, Xiaomeng, Dong, Meng. Oral Probiotic Expressing Human Ethanol Dehydrogenase Attenuates Damage Caused by Acute Alcohol Consumption in Mice. MICROBIOLOGY SPECTRUM[J]. 2023, 11(3): http://dx.doi.org/10.1128/spectrum.04294-22.[2] Shouli Yuan, Meng Dong, Hanlin Zhang, Xiaoxiao Jiang, Chunlong Yan, Rongcai Ye, Huiqiao Zhou, Li Chen, Huiru Lian, Wanzhu Jin. Ginsenoside PPD inhibit the activation of HSCs by directly targeting TGFβR1. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2022, 194: 556-562, [3] Ye, Rongcai, Yan, Chunlong, Zhou, Huiqiao, Zhang, Chuanhai, Huang, Yuanyuan, Dong, Meng, Zhang, Hanlin, Lin, Jun, Jiang, Xiaoxiao, Yuan, Shouli, Chen, Li, Jiang, Rui, Cheng, Ziyu, Zheng, Kexin, Yu, Anni, Zhang, Qiaoli, Quan, Linhu, Jin, Wanzhu. Brown adipose tissue activation with ginsenoside compound K ameliorates polycystic ovary syndrome. BRITISH JOURNAL OF PHARMACOLOGY[J]. 2022, 179(18): 4563-4574, http://dx.doi.org/10.1111/bph.15909.[4] Yan, ChunLong, Lin, Jun, Huang, YuanYuan, Gao, QingShan, Piao, ZhengYu, Yuan, ShouLi, Chen, Li, Ren, Xue, Ye, RongCai, Dong, Meng, Zhang, HanLin, Zhou, HuiQiao, Jiang, XiaoXiao, Jin, WanZhu, Zhou, XuMing, Yan, ChangGuo. Population genomics reveals that natural variation in PRDM16 contributes to cold tolerance in domestic cattle. ZOOLOGICAL RESEARCH[J]. 2022, 43(2): 275-284, http://dx.doi.org/10.24272/j.issn.2095-8137.2021.360.[5] zhou huiqiao, zhang hanlin, ye rongcai, Yan chunlong, Lin Jun, Huang, Yuanyuan, jiang xiaoxiao, 袁守丽, chen li, Jiang, Rui, zheng kexin, 程子昱, zhang zhi, Meng, Dong, 金万洙. Pantothenate protects against obesity via brown adipose tissue activation. Am J Physiol Endocrinol Metab.[J]. 2022, 323(1): E69-E79, [6] Lin, Jun, Jiang, Xiaoxiao, Dong, Meng, Liu, Xiaomeng, Shen, Qiwei, Huang, Yuanyuan, Zhang, Hanlin, Ye, Rongcai, Zhou, Huiqiao, Yan, Chunlong, Yuan, Shouli, Wu, Xiangnan, Chen, Li, Wang, Yanfang, He, Min, Tao, Yi, Zhang, Zhaoyun, Jin, Wanzhu. Hepatokine Pregnancy Zone Protein Governs the Diet-Induced Thermogenesis Through Activating Brown Adipose Tissue. ADVANCED SCIENCE[J]. 2021, 8(21): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000695146100001.[7] Yuan, Shouli, Dong, Meng, Zhang, Hanlin, Xu, Hongde, Wang, Qi, Yan, Chunlong, Ye, Rongcai, Jiang, Xiaoxiao, Zhou, Huiqiao, Chen, Li, Cheng, Jun, Xie, Wen, Jin, Wanzhu. Oral delivery of a Lactococcus lactis expressing extracellular TGF beta R2 alleviates hepatic fibrosis. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2021, 105(14-15): 6007-6018, http://dx.doi.org/10.1007/s00253-021-11485-7.[8] Ye, Rongcai, Yan, Chunlong, Zhou, Huiqiao, Huang, Yuanyuan, Dong, Meng, Zhang, Hanlin, Jiang, Xiaoxiao, Yuan, Shouli, Chen, Li, Jiang, Rui, Cheng, Ziyu, Zheng, Kexin, Zhang, Qiaoli, Jin, Wanzhu. Brown Adipose Tissue Activation by Cold Treatment Ameliorates Polycystic Ovary Syndrome in Rat. FRONTIERS IN ENDOCRINOLOGY[J]. 2021, 12: http://dx.doi.org/10.3389/fendo.2021.744628.[9] Zhang, Haolin, Liu, Hong, Kataoka, Sachi, Kinukawa, Masashi, Uchiyama, Kyoko, Kambe, Jun, Watanabe, Gen, Jin, Wanzhu, Nagaoka, Kentaro. L-amino acid oxidase 1 in sperm is associated with reproductive performance in male mice and bulls. BIOLOGY OF REPRODUCTION[J]. 2021, 104(5): 1154-1161, http://dx.doi.org/10.1093/biolre/ioab024.[10] Kambe, Jun, Sasaki, Yu, Inoue, Ryo, Tomonaga, Shozo, Kinjo, Teruo, Watanabe, Gen, Jin, Wanzhu, Nagaoka, Kentaro. Analysis of infant microbiota composition and the relationship with breast milk components in the Asian elephant (Elephas maximus) at the zoo. JOURNAL OF VETERINARY MEDICAL SCIENCE[J]. 2020, 82(7): 983-989, https://www.webofscience.com/wos/woscc/full-record/WOS:000589258000020.[11] 赵建国. Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis. protein cell. 2020, [12] Quan, LinHu, Zhang, Chuanhai, Dong, Meng, Jiang, Jun, Xu, Hongde, Yan, Chunlong, Liu, Xiaomeng, Zhou, Huiqiao, Zhang, Hanlin, Chen, Li, Zhong, FeiLiang, Luo, ZhaoBo, Lam, SinMan, Shui, Guanghou, Li, Donghao, Jin, Wanzhu. Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation. GUT[J]. 2020, 69(7): 1239-1247, https://www.webofscience.com/wos/woscc/full-record/WOS:000569655200014.[13] Huang, Yuanyuan, Zhang, Hanlin, Dong, Meng, Zhang, Lei, Lin, Jun, Ye, Rongcai, Zhou, Huiqiao, Liu, Xiaomeng, Jin, Wanzhu. miR17-92 cluster drives white adipose tissue browning. JOURNAL OF MOLECULAR ENDOCRINOLOGY[J]. 2020, 65(3): 97-107, https://www.webofscience.com/wos/woscc/full-record/WOS:000574794100006.[14] Li, Baoguo, Li, Li, Li, Min, Lam, Sin Man, Wang, Guanlin, Wu, Yingga, Zhang, Hanlin, Niu, Chaoqun, Zhang, Xueying, Liu, Xue, Hambly, Catherine, Jin, Wanzhu, Shui, Guanghou, Speakman, John R. Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue. CELL REPORTS[J]. 2019, 26(10): 2720-+, https://doaj.org/article/2916f897cb2d42f4b6f227f04af603ce.[15] Pan, RuiYuan, Ma, Jun, Kong, XiangXi, Wang, XiaoFeng, Li, ShuoShuo, Qi, XiaoLong, Yan, YuHan, Cheng, Jinbo, Liu, Qingsong, Jin, Wanzhu, Tan, ChangHeng, Yuan, Zengqiang. Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-beta clearance. SCIENCE ADVANCES[J]. 2019, 5(2): [16] Na Yin, Hanlin Zhang, Rongcai Ye, Meng Dong, Jun Lin, Huiqiao Zhou, Yuanyuan Huang, Li Chen, Xiaoxiao Jiang, Kentaro Nagaoka, Chuanhai Zhang, Wanzhu Jin. Fluvastatin Sodium Ameliorates Obesity through Brown Fat Activation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2019, 20(7): https://doaj.org/article/518aee4de62b44cfb2b344d44d8cf55a.[17] Shigeno, Yuko, Zhang, Haolin, Banno, Taihei, Usuda, Kento, Nochi, Tomonori, Inoue, Ryo, Watanabe, Gen, Jin, Wanzhu, Benno, Yoshimi, Nagaoka, Kentaro. Gut microbiota development in mice is affected by hydrogen peroxide produced from amino acid metabolism during lactation. FASEB JOURNAL[J]. 2019, 33(3): 3343-3352, [18] Na Yin, Hanlin Zhang, Rongcai Ye, Meng Dong, Jun Lin, Huiqiao Zhou, Yuanyuan Huang, Li Chen, Xiaoxiao Jiang, Kentaro Nagaoka, Chuanhai Zhang, Wanzhu Jin. Fluvastatin Sodium Ameliorates Obesity through Brown Fat Activation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2019, 20(7): https://doaj.org/article/518aee4de62b44cfb2b344d44d8cf55a.[19] Meng Dong, Jun Lin, Wonchung Lim, Wanzhu Jin, Hyuek Jong Lee. Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia. 医学前沿:英文版[J]. 2018, 12(2): 130-138, http://lib.cqvip.com/Qikan/Article/Detail?id=674999775.[20] Dong, Meng, Lin, Jun, Lim, Wonchung, Jin, Wanzhu, Lee, Hyuek Jong. Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia. FRONTIERS OF MEDICINEnull. 2018, 12(2): 130-138, http://lib.cqvip.com/Qikan/Article/Detail?id=674999775.[21] Zhang, Chuanhai, Wang, Jingjing, Zhang, Hanlin, Liu, Shunai, Lee, Hyuek Jong, Jin, Wanzhu, Cheng, Jun. Hepatitis C virus core protein induces hepatic steatosis via Sirt1-dependent pathway. LIVER INTERNATIONAL[J]. 2018, 38(5): 803-812, https://www.webofscience.com/wos/woscc/full-record/WOS:000435855300007.[22] Usuda, Kento, Kawase, Takahiro, Shigeno, Yuko, Fukuzawa, Susumu, Fujii, Kazuki, Zhang, Haolin, Tsukahara, Takamitsu, Tomonaga, Shozo, Watanabe, Gen, Jin, Wanzhu, Nagaoka, Kentaro. Hippocampal metabolism of amino acids by L-amino acid oxidase is involved in fear learning and memory. SCIENTIFIC REPORTS[J]. 2018, 8(1): https://doaj.org/article/f7ef365258f74111bd746a698204ff71.[23] Wang, LingFang, Miao, LianJie, Wang, XiaoNv, Huang, CongCong, Qian, YiSong, Huang, Xuan, Wang, XiaoLei, Jin, WanZhu, Ji, GuangJu, Fu, Mingui, Deng, KeYu, Xin, HongBo. CD38 deficiency suppresses adipogenesis and lipogenesis in adipose tissues through activating Sirt1/PPAR gamma signaling pathway. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE[J]. 2018, 22(1): 101-110, https://www.webofscience.com/wos/woscc/full-record/WOS:000418759200010.[24] Piao, Zhengyu, Zhai, Baiqiang, Jiang, Xiaoxiao, Dong, Meng, Yan, Changguo, Lin, Jun, Jin, Wanzhu. Reduced adiposity by compensatory WAT browning upon iBAT removal in mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2018, 501(3): 807-813, https://www.webofscience.com/wos/woscc/full-record/WOS:000436057500030.[25] Hu, Tao, Yuan, Xiaoxue, Wei, Gang, Luo, Haoshu, Lee, Hyuek Jong, Jin, Wanzhu. Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice. EUROPEAN JOURNAL OF NUTRITION[J]. 2018, 57(1): 391-403, http://dx.doi.org/10.1007/s00394-017-1433-z.[26] You, Yilin, Yuan, Xiaoxue, Liu, Xiaomeng, Liang, Chen, Meng, Minghui, Huang, Yuanyuan, Han, Xue, Guo, Jielong, Guo, Yu, Ren, Chenglong, Zhang, Qianwen, Sun, Xiangyu, Ma, Tingting, Liu, Guojie, Jin, Wanzhu, Huang, Weidong, Zhan, Jicheng. Cyanidin-3-glucoside increases whole body energy metabolism by upregulating brown adipose tissue mitochondrial function. MOLECULAR NUTRITION & FOOD RESEARCH[J]. 2017, 61(11): [27] Wu, Rong, Sun, Jianguang, Wang, Jiqiu, Li, Binhua, Liu, Qingsong, Ning, Guang, Jin, Wanzhu, Yuan, Zengqiang. c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice. DIABETOLOGIA[J]. 2017, 60(5): 900-910, http://dx.doi.org/10.1007/s00125-016-4202-2.[28] Hu Tao, Yuan Xiaoxue, Ye Rongcai, Zhou Huiqiao, Lin Jun, Zhang Chuanhai, Zhang Hanlin, Wei Gang, Dong Meng, Huang Yuanyuan, Lim Wonchung, Liu Qingsong, Lee Hyuek Jong, Jin Wanzhu. Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat. THE JOURNAL OF NUTRITIONAL BIOCHEMISTRY[J]. 2017, 47: 21-28, http://dx.doi.org/10.1016/j.jnutbio.2017.04.012.[29] Yuan, Xiaoxue, Wei, Gang, You, Yilin, Huang, Yuanyuan, Lee, Hyuek Jong, Dong, Meng, Lin, Jun, Hu, Tao, Zhang, Hanlin, Zhang, Chuanhai, Zhou, Huiqiao, Ye, Rongcai, Qi, Xiaolong, Zhai, Baiqiang, Huang, Weidong, Liu, Shunai, Xie, Wen, Liu, Qingsong, Liu, Xiaomeng, Cui, Chengbi, Li, Donghao, Zhan, Jicheng, Cheng, Jun, Yuan, Zengqiang, Jin, Wanzhu. Rutin ameliorates obesity through brown fat activation. FASEB JOURNAL[J]. 2017, 31(1): 333-+, http://dx.doi.org/10.1096/fj.201600459RR.[30] Yao, Lu, Cui, Xiaona, Chen, Qi, Yang, Xiaoying, Fang, Fude, Zhang, Jun, Liu, Guoqing, Jin, Wanzhu, Chang, Yongsheng. Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat. CELL REPORTS[J]. 2017, 20(3): 641-654, http://dx.doi.org/10.1016/j.celrep.2017.06.069.[31] Shen, Qiwei, Yang, Yeping, Liu, Wenjuan, Wang, Meng, Shao, Yikai, Xu, Bo, Zhao, Xiaolong, Zhu, Jingjing, Hua, Rong, Jin, Wanzhu, Hu, Zhiyu, Kim, Jae Bum, Wang, Qinghua, Li, Yiming, Zang, Mengwei, Yao, Qiyuan, Zhang, Zhaoyun. Organ-specific alterations in circadian genes by vertical sleeve gastrectomy in an obese diabetic mouse model. SCIENCE BULLETIN[J]. 2017, 62(7): 467-469, http://dx.doi.org/10.1016/j.scib.2017.03.014.[32] Lin, Jun, Cao, Chunwei, Tao, Cong, Ye, Rongcai, Dong, Meng, Zheng, Qiantao, Wang, Chao, Jiang, Xiaoxiao, Qin, Guosong, Yan, Changguo, Li, Kui, Speakman, John R, Wang, Yanfang, Jin, Wanzhu, Zhao, Jianguo. Cold adaptation in pigs depends on UCP3 in beige adipocytes. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2017, 9(5): 364-375, https://www.webofscience.com/wos/woscc/full-record/WOS:000417761200003.[33] 金万洙. Hepatitis C virus core protein induces hepatic steatosis via Sirt1‐dependent pathway. Liver International. 2017, [34] Zheng Qiantao, Lin Jun, Huang Jiaojiao, Zhang Hongyong, Zhang Rui, XueYing Zhang, Cao Chunwei, Catherine Hambly, Qin Guosong, Yao Jing, Song Ruigao, Jia Qitao, Wang Xiao, YongShun Li, Zhang Nan, ZhengYu Piao, Ye Rongcai, John RSpeakman, Wang Hongmei, Zhou Qi, Wang Yanfang, Jin Wanzhu, Zhao Jianguo. Reconstitution of UCP1 Using CRISPR/Cas9 in the White Adipose Tissue of Pigs Decreases Fat Deposition and Improves Thermogenic Capacity. PNAS[J]. 2017, 114(45): E9474-E9482, http://ir.ioz.ac.cn/handle/000000/13129.[35] Hu, Tao, Yuan, Xiaoxue, Ye, Rongcai, Zhou, Huiqiao, Lin, Jun, Zhang, Chuanhai, Zhang, Hanlin, Wei, Gang, Dong, Meng, Huang, Yuanyuan, Lim, Wonchung, Liu, Qingsong, Lee, Hyuek Jong, Jin, Wanzhu. Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat. JOURNAL OF NUTRITIONAL BIOCHEMISTRY[J]. 2017, 47: 21-28, http://dx.doi.org/10.1016/j.jnutbio.2017.04.012.[36] Wu, Rong, Liu, Xiaomeng, Sun, Jianguang, Chen, Hong, Ma, Jun, Dong, Meng, Peng, Shengyi, Wang, Jiqiu, Ding, Jianqing, Li, Donghao, Speakman, John R, Ning, Guang, Jin, Wanzhu, Yuan, Zengqiang. DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue. CELL DISCOVERY[J]. 2017, 3: 16054-, http://dx.doi.org/10.1038/celldisc.2016.54.[37] Zheng, Qiantao, Lin, Jun, Huang, Jiaojiao, Zhang, Hongyong, Zhang, Rui, Zhang, Xueying, Cao, Chunwei, Hambly, Catherine, Qin, Guosong, Yao, Jing, Song, Ruigao, Jia, Qitao, Wang, Xiao, Li, Yongshun, Zhang, Nan, Piao, Zhengyu, Ye, Rongcai, Speakman, John R, Wang, Hongmei, Zhou, Qi, Wang, Yanfang, Jin, Wanzhu, Zhao, Jianguo. Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 114(45): E9474-E9482, https://www.webofscience.com/wos/woscc/full-record/WOS:000414631200009.[38] Li, Li, Li, Baoguo, Li, Min, Niu, Chaoqun, Wang, Guanlin, Li, Ting, Krol, Elzbieta, Jin, Wanzhu, Speakman, John R. Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo. MOLECULAR METABOLISM[J]. 2017, 6(10): 1198-1211, http://dx.doi.org/10.1016/j.molmet.2017.07.015.[39] Wang Haibin, QingSong Liu, Hyuek Jong Lee, Chen Zijiang, Jin Wanzhu, Yuan Xiaoxue, Hu Tao, Zhao Han, Huang Yuanyuan, Ye Rongcai, Lin Jun, Zhang Chuanhai, Zhang Hanlin, Wei Gang, Zhou Huiqiao, Dong Meng, Jun Zhao. Brown Adipose Tissue Transplantation Ameliorates Polycystic Ovary Syndrome. PNAS[J]. 2016, 113(10): 2708-2713, http://ir.ioz.ac.cn/handle/000000/12285.[40] Zhang, Chuanhai, Weng, Yibing, Shi, Fangxiong, Jin, Wanzhu. The Engrailed-1 Gene Stimulates Brown Adipogenesis. STEM CELLS INTERNATIONAL[J]. 2016, 2016: https://doaj.org/article/17e82c7b756a42d6a30a0ede4cea7235.[41] Yuan, Xiaoxue, Hu, Tao, Zhao, Han, Huang, Yuanyuan, Ye, Rongcai, Lin, Jun, Zhang, Chuanhai, Zhang, Hanlin, Wei, Gang, Zhou, Huiqiao, Dong, Meng, Zhao, Jun, Wang, Haibin, Liu, Qingsong, Lee, Hyuek Jong, Jin, Wanzhu, Chen, ZiJiang. Brown adipose tissue transplantation ameliorates polycystic ovary syndrome. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2016, 113(10): 2708-2713, http://dx.doi.org/10.1073/pnas.1523236113.[42] Yuan, Xiaoxue, Dong, Meng, Lee, Hyuek Jong, Jin, Wanzhu. Brown adipose tissue and its therapeutic application. SCIENCE BULLETIN[J]. 2016, 61(19): 1498-1503, http://dx.doi.org/10.1007/s11434-016-1051-9.[43] Liu, Xiaomeng, Wang, Siping, You, Yilin, Meng, Minghui, Zheng, Zongji, Dong, Meng, Lin, Jun, Zhao, Qianwei, Zhang, Chuanhai, Yuan, Xiaoxue, Hu, Tao, Liu, Lieqin, Huang, Yuanyuan, Zhang, Lei, Wang, Dehua, Zhan, Jicheng, Lee, Hyuek Jong, Speakman, John R, Jin, Wanzhu. Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice. ENDOCRINOLOGY[J]. 2015, 156(7): 2461-2469, http://dx.doi.org/10.1210/en.2014-1598.[44] 汪玲芳, 邓柯玉, 辛洪波, 汪小女, 苗连杰, 邓立彬, 金万洙, 王小磊. CD38缺失通过Sirt1/PPARγ信号通路抑制脂肪细胞分化. 中国病理生理杂志[J]. 2015, 31(10): 1880-, http://ir.ioz.ac.cn/handle/000000/11243.[45] Zhang, Hanlin, Huang, Yuanyuan, Lee, Hyuek Jong, Jin, Wanzhu. Zic1 negatively regulates brown adipogenesis in C3H10T1/2 cells. SCIENCE BULLETIN[J]. 2015, 60(11): 1033-1035, http://www.corc.org.cn/handle/1471x/2157795.[46] You, Yilin, Yuan, Xiaoxue, Lee, Hyuek Jong, Huang, Weidong, Jin, Wanzhu, Zhan, Jicheng. 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