主要研究逆转录病毒急性和持续性感染中与宿主细胞的相互作用。利用原代细胞、活体组织体外培养，及MLV（鼠淋巴细胞病毒）感染的小鼠模型，研究逆转录病毒的黏膜感染机制，分析病毒对免疫细胞功能调控作用，寻找病毒初始感染诊断或阻断策略；通过基因表达组学、新型蛋白修饰组学和细胞分子生物学手段，鉴定调控HIV-1复制的关键宿主因子，揭示HIV持续/潜伏感染的调控机制，探讨基于宿主因子表达或修饰的抗病毒感染治疗的新靶标和新手段。

   

071005-微生物学
085238-生物工程
071009-细胞生物学

病毒免疫学
艾滋病毒
宿主细胞对HIV-1复制调控及病毒潜伏/持续性感染分子机制

   

研究生

理学博士

2009. 1-今, 中科院上海巴斯德研究所

2009-03~现在, 上海巴斯德研究所, 研究员

   

（1） 云南省艾滋病合并深部真菌感染的系统临床特性和应用, 三等奖, 省级, 2014

   

[1] Front Cell Infect Microbiol. 2024, 第 6 作者  通讯作者  
[2] Virol Sin. 2024, 第 10 作者  通讯作者  
[3] Tianyang Li, Yang Yang, Yongqi Li, Zhengmin Wang, Faxiang Ma, Runqi Luo, Xiaoming Xu, Guo Zhou, Jianhua Wang, Junqi Niu, Guoyue Lv, Ian N Crispe, Zhengkun Tu. Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike protein. THE JOURNAL OF CLINICAL INVESTIGATION[J]. 2022, 第 9 作者132(4): https://doaj.org/article/0cdf5c96a832487e8531efbfa94475f4.
[4] Wu, MengLi, Liu, FengLiang, Sun, Jing, Li, Xin, Qin, JianRu, Yan, QiHong, Jin, Xia, Chen, XinWen, Zheng, YongTang, Zhao, JinCun, Wang, JianHua. Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in mice. ZOOLOGICAL RESEARCH[J]. 2022, 第 11 作者  通讯作者  43(3): 457-468, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7335121&detailType=1.
[5] MengLi Wu, FengLiang Liu, Jing Sun, Xin Li, XiaoYan He, HongYi Zheng, YanHeng Zhou, Qihong Yan, Ling Chen, GuoYing Yu, Junbiao Chang, Xia Jin, Jincun Zhao, XinWen Chen, YongTang Zheng, JianHua Wang. SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury. SIG TRANSDUCT TARGET THER[J]. 2022, 第 16 作者  通讯作者  7(1): 295-309, http://lib.cqvip.com/Qikan/Article/Detail?id=7106667506.
[6] 张向菲, 刘畅, 胡冰, 王瑞娟, 秦建如, 王建华. EV71抗病毒药物及疫苗研究进展. 微生物学报[J]. 2022, 第 6 作者62(4): 1216-1230, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20220404?st=article_issue.
[7] Han, Jingwan, Zhou, YanHeng, Ma, Yingying, Zhu, Guoxin, Zhang, Dong, Zhu, Bo, Cheng, Tong, Wang, Lanfeng, Wang, JianHua, Li, Lin, Zhang, Chiyu. A New HIV-1 K28E32-Reverse Transcriptase Variant Associated with the Rapid Expansion of CRF07_BC among Men Who Have Sex with Men. MICROBIOLOGY SPECTRUM[J]. 2022, 第 9 作者10(5): http://dx.doi.org/10.1128/spectrum.02545-22.
[8] Jing Wen, Caiqi Zhao, Jie Chen, Shuting Song, Zhekai Lin, Shitao Xie, Huaxin Qi, Jianhua Wang, Xiao Su. Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription. CELL INSIGHT[J]. 2022, 第 8 作者1(3): 100028, 
[9] Jing Wen, Xin Li, QingXia Zhao, XiaoFan Yang, MengLi Wu, Qihong Yan, Junbiao Chang, Haikun Wang, Xia Jin, Xiao Su, Kai Deng, Ling Chen, JianHua Wang. Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt + T cells. EMERGING MICROBES & INFECTIONS. 2022, 第 13 作者11(1): 391-405, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812804/.
[10] Song, ShuTing, Wu, MengLi, Zhang, HaiJiao, Su, Xiao, Wang, JianHua. Mast Cell Activation Triggered by Retrovirus Promotes Acute Viral Infection. FRONTIERS IN MICROBIOLOGY[J]. 2022, 第 5 作者  通讯作者  13: http://dx.doi.org/10.3389/fmicb.2022.798660.
[11] Yan, Qihong, Li, Pingchao, Ye, Xianmiao, Huang, Xiaohan, Feng, Bo, Ji, Tianxing, Chen, Zhilong, Li, Feng, Zhang, Yudi, Luo, Kun, Chen, Fengjuan, Mo, Xiaoneng, Wang, Jianhua, Feng, Liqiang, Hu, Fengyu, Lei, Chunliang, Qu, Linbing, Chen, Ling. Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients. JOURNAL OF IMMUNOLOGY[J]. 2021, 第 13 作者206(9): 2146-2159, http://dx.doi.org/10.4049/jimmunol.2001325.
[12] Zuo, Lulu, Liu, Kai, Liu, Honglian, Hu, Yihong, Zhang, Zhijie, Qin, Jianru, Xu, Qinggang, Peng, Ke, Jin, Xia, Wang, JianHua, Zhang, Chiyu. Trend of HIV-1 drug resistance in China: A systematic review and meta-analysis of data accumulated over 17 years (2001-2017). ECLINICALMEDICINE[J]. 2020, 第 10 作者18: https://doaj.org/article/17a809da50d14d58bb0e84f3f5931a2f.
[13] Tingxia Lyu, Yongsong Yue, Evelyn Hsieh, Yang Han, Ting Zhu, Xiaojing Song, Wei Cao, Wei Lyu, Jianhua Wang, Taisheng Li. HIV-1 CRF01_AE subtype and HIV-1 DNA level among patients with chronic HIV-1 infection: a correlation study. BMC INFECTIOUS DISEASES[J]. 2020, 第 9 作者20(1): 1-8, http://dx.doi.org/10.1186/s12879-020-4785-6.
[14] Li Ma, QingAn Jiang, Li Sun, Xianguang Yang, Hai Huang, Xia Jin, Chiyu Zhang, JianHua Wang. X-Linked RNA-Binding Motif Protein Modulates HIV-1 Infection of CD4+ T Cells by Maintaining the Trimethylation of Histone H3 Lysine 9 at the Downstream Region of the 5′ Long Terminal Repeat of HIV Proviral DNA. MBIO[J]. 2020, 第 8 作者  通讯作者  11(2): https://doaj.org/article/63683f2ea0b84f70b5ae2da42577f849.
[15] Sun, Li, Peng, Youmei, Yu, Wenquan, Zhang, Yan, Liang, Lan, Song, Chuanjun, Hou, Jiao, Qiao, Yan, Wang, Qingduan, Chen, Jingyu, Wu, Mengli, Zhang, Dongwei, Li, Ertong, Han, Zhifu, Zhao, Qingxia, Jin, Xia, Zhang, Bailing, Huang, Zhiwei, Chai, Jijie, Wang, JianHua, Chang, Junbiao. Mechanistic Insight into Antiretroviral Potency of 2 '-Deoxy-2 '-beta-fluoro-4 '-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 第 20 作者  通讯作者  63(15): 8554-8566, https://www.webofscience.com/wos/woscc/full-record/WOS:000562941200043.
[16] Qu, Di, Sun, WeiWei, Li, Li, Ma, Li, Sun, Li, Ji, Xia, Li, Taisheng, Hou, Wei, Wang, JianHua. Long noncoding RNA MALAT1 releases epigenetic silencing of HIV-1 replication by displacing the polycomb repressive complex 2 from binding to the LTR promoter. NUCLEIC ACIDS RESEARCH[J]. 2019, 第 9 作者  通讯作者  47(6): 3013-3027, https://www.webofscience.com/wos/woscc/full-record/WOS:000467964800028.
[17] Yanpeng Li, Xuemin Fu, Jinmin Ma, Jianhui Zhang, Yihong Hu, Wei Dong, Zhenzhou Wan, Qiongfang Li, YiQun Kuang, Ke Lan, Xia Jin, JianHua Wang, Chiyu Zhang. Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children. NATURE COMMUNICATIONS[J]. 2019, 第 12 作者  通讯作者  10(1): 1-12, https://doaj.org/article/a844a884678c47ab8be737931cdfe8ea.
[18] YanHeng Zhou, Li Sun, Jun Chen, WeiWei Sun, Li Ma, Yang Han, Xia Jin, QingXia Zhao, Taisheng Li, Hongzhou Lu, Xiu Qiu, JianHua Wang. Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation. MBIO[J]. 2019, 第 12 作者  通讯作者  10(6): https://doaj.org/article/09d1ba188e9944a2a55d2c3e0cc4807a.
[19] TianJiao Fan, Li Sun, XianGuang Yang, Xia Jin, WeiWei Sun, JianHua Wang. The Establishment of an In Vivo HIV-1 Infection Model in Humanized B-NSG Mice. VIROLOGICA SINICA. 2019, 第 6 作者  通讯作者  35(4): 417-425, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462958/.
[20] WeiWei Sun, Shi Jiao, Li Sun, Zhaocai Zhou, Xia Jin, JianHua Wang. SUN2 Modulates HIV-1 Infection and Latency through Association with Lamin A/C To Maintain the Repressive Chromatin. MBIO[J]. 2018, 第 6 作者  通讯作者  9(3): IR_Article.
[21] Wang Jianhua. Scaffold attachment factor B suppresses HIV-1 infection of CD4+ cells by preventing binding of RNA polymerase II to HIV-1’s long terminal repeat. J Bio Chem. 2018, 第 1 作者  通讯作者  
[22] Kuang, WenDong, Zhou, YanHeng, Zhong, Ping, Zhang, Chiyu, Wang, JianHua. Amino acids at positions 3, 168, and 169 are associated with the ability of Nef proteins from HIV-1 CRF01_AE to downmodulate CD4. JOURNAL OF MEDICAL VIROLOGY[J]. 2017, 第 5 作者  通讯作者  89(10): 1788-1795, 
[23] Ren, XiaoXin, Ma, Li, Sun, WeiWei, Kuang, WenDong, Li, TaiSheng, Jin, Xia, Wang, JianHua. Dendritic cells maturated by co-culturing with HIV-1 latently infected Jurkat T cells or stimulating with AIDS-associated pathogens secrete TNF-alpha to reactivate HIV-1 from latency. VIRULENCE[J]. 2017, 第 7 作者  通讯作者  8(8): 1732-1743, https://www.webofscience.com/wos/woscc/full-record/WOS:000419183300033.
[24] Wang Jianhua. Naf1 regulates HIV-1 latency by suppressing viral promoter-driven gene expression in primary CD4+ T cells.. J Virol.. 2016, 第 1 作者  通讯作者  
[25] YiWen Qian, Chuan Li, AiPing Jiang, Shengfang Ge, Ping Gu, Xianqun Fan, TaiSheng Li, Xia Jin, JianHua Wang, ZhiLiang Wang. HIV-1 gp120 Glycoprotein Interacting with Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN) Down-Regulates Tight Junction Proteins to Disrupt the Blood Retinal Barrier and Increase Its Permeability *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2016, 第 9 作者291(44): 22977-22987, http://dx.doi.org/10.1074/jbc.M116.744615.
[26] Yang, FuChun, Kuang, WenDong, Li, Chuan, Sun, WeiWei, Qu, Di, Wang, JianHua. Toll-Interacting Protein Suppresses HIV-1 Long-Terminal-Repeat-Driven Gene Expression and Silences the Post-Integrational Transcription of Viral Proviral DNA. PLOS ONE[J]. 2015, 第 6 作者  通讯作者  10(4): https://doaj.org/article/bcd85bc6233a4b0687ed0f03450dc7c9.
[27] Wang Jianhua. Human mucosal mast cells capture HIV-1 and mediate viral trans-infection of CD4+ T cells. J Virol.. 2015, 第 1 作者  通讯作者  
[28] Jiang, AiPing, Jiang, JinFeng, Guo, MingGao, Jin, YongMei, Li, YuYe, Wang, JianHua. Human Blood-Circulating Basophils Capture HIV-1 and Mediate Viral trans-Infection of CD4(+) T Cells. JOURNAL OF VIROLOGY[J]. 2015, 第 6 作者  通讯作者  89(15): 8050-8062, https://www.webofscience.com/wos/woscc/full-record/WOS:000358277800049.
[29] Ren, XiaoXin, Li, Chuan, Xiong, SiDong, Huang, Zhong, Wang, JianHua, Wang, HaiBo. Antibodies to P-selectin glycoprotein ligand-1 block dendritic cell-mediated enterovirus 71 transmission and prevent virus-induced cells death. VIRULENCE[J]. 2015, 第 5 作者  通讯作者  6(8): 802-808, https://www.webofscience.com/wos/woscc/full-record/WOS:000366587600010.
[30] Ma, Li, Shen, ChanJuan, Cohen, Eric A, Xiong, SiDong, Wang, JianHua. miRNA-1236 Inhibits HIV-1 Infection of Monocytes by Repressing Translation of Cellular Factor VprBP. PLOS ONE[J]. 2014, 第 5 作者  通讯作者  9(6): http://dx.doi.org/10.1371/journal.pone.0099535.
[31] Liu, Wan, Qin, Yan, Bai, Lei, Lan, Ke, Wang, JianHua. Kaposi's-sarcoma-associated-herpesvirus-activated dendritic cells promote HIV-1 trans-infection and suppress CD4(+) T cell proliferation. VIROLOGY[J]. 2013, 第 5 作者  通讯作者  440(2): 150-159, http://dx.doi.org/10.1016/j.virol.2013.02.018.
[32] RongRong Zhai, AiPing Jiang, HaiBo Wang, Li Ma, XiaoXin Ren, JinFeng Jiang, Li Wu, JiFu Wei, JianHua Wang. Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells. VIROLOGY. 2013, 第 9 作者163-172, http://dx.doi.org/10.1016/j.virol.2013.04.009.
[33] Qin, Yan, Li, YuYe, Jiang, Aiping, Jiang, JinFeng, Wang, JianHua. Stimulation of Cryptococcus neoformans isolated from skin lesion of AIDS patient matures dendritic cells and promotes HIV-1 trans-infection. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2012, 第 5 作者  通讯作者  423(4): 709-714, http://dx.doi.org/10.1016/j.bbrc.2012.06.020.
[34] Wang Jianhua. IFN-k inhibits HIV-1 integration and post-transcriptional events in vitro, but there is only limited in vivo repression of viral production. 2012, 第 1 作者  通讯作者  
[35] Wang Jianhua. Translation of Pur-α is targeted by cellular miRNAs to modulate the differentiation-dependent susceptibility of monocytes to HIV-1 infection. FASEB J. 2012, 第 1 作者  通讯作者  
[36] Qin, Yan, Li, Yuye, Liu, Wan, Tian, Renrong, Guo, Qianqian, Li, Shaoyou, Li, Hongbin, Zhang, Daojun, Zheng, Yongtang, Wu, Li, Lan, Ke, Wang, Jianhua. Penicillium marneffei-Stimulated Dendritic Cells Enhance HIV-1 Trans-Infection and Promote Viral Infection by Activating Primary CD4(+) T Cells. PLOS ONE[J]. 2011, 第 12 作者6(11): http://www.irgrid.ac.cn/handle/1471x/334666.
[37] Ren Xiao-Xin, Wang Hai-Bo, Li Chuan, Jiang Jin-Feng, Xiong Si-Dong, Jin Xia, Wu Li, Wang Jian-Hua. HIV-1 Nef-associated Factor 1 Enhances Viral Production by Interacting with CRM1 to Promote Nuclear Export of Unspliced HIV-1 gag mRNA *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 第 8 作者291(9): 4580-4588, http://dx.doi.org/10.1074/jbc.M115.706135.
[38] Shuting Song, Zhekai Lin, Caiqi Zhao, Jing Wen, Jie Chen, Shitao Xie, Huaxin Qi, Jianhua Wang, Xiao Su. Vagal-mAChR4 signaling promotes Friend virus complex (FV)-induced acute erythroleukemia. VIROLOGICA SINICA. 第 8 作者http://dx.doi.org/10.1016/j.virs.2023.05.005.

   

（ 1 ） 宿主因子Tollip抑制HIV-1转录及调控病毒潜伏感染的分子机制研究, 主持, 国家级, 2016-01--2019-12
（ 2 ） HIV-1 Nef蛋白与宿主蛋白Naf1相互作用调控病毒潜伏感染, 主持, 国家级, 2016-01--2018-12

已指导学生

杨福春  01  19178  

秦琰  01  19178  

刘婉  02  19606  

李川  01  19178  

江爱平  01  19178  

现指导学生

况文东  01  19182  

孙玮玮  01  19178  

曲迪  01  19178