基本信息
李栋  男  博导  中国科学院生物物理研究所
电子邮件: lidong@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码: 100101

招生信息

   
招生专业
071011-生物物理学
080300-光学工程
071009-细胞生物学
招生方向
研制光学显微活体成像技术,特别是超高分辨率技术,并探索其细胞生物学应用
探索先进显微镜技术的生物学应用
探索先进显微镜技术的生物学应用

教育背景

2006-08--2011-08   香港科技大学   博士,电子与计算机学系
2002-09--2006-06   浙江大学   学士,光电信息工程学系

工作经历

   
工作简历
2016-01~现在, 中国科学院生物物理研究所, 研究员,博导
2011-12~2015-12,霍华德休斯医学研究所,Janelia研究园, 博士后

专利与奖励

   
奖励信息
(1) PicoQuant青年研究员奖, 一等奖, 其他, 2015
(2) 香港青年科学家奖, 一等奖, 其他, 2011
(3) 浙江大学一等奖学金, 一等奖, 研究所(学校), 2005
(4) 浙江大学一等奖学金, 一等奖, 研究所(学校), 2004
专利成果
[1] 李栋, 乔畅, 李子薇, 张思微. 一种三维超分辨率光片显微成像方法和显微镜. CN: CN113917677A, 2022-01-11.

[2] 李栋, 乔畅, 王松岳. 超分辨率图像的处理方法及装置、电子设备、存储介质. CN: CN113781298A, 2021-12-10.

[3] 李栋, 王新禹. 一种邻近生物素连接酶及其应用. CN: CN113481173A, 2021-10-08.

[4] 李栋, 乔畅, 李迪, 戴琼海. 图像超分辨率处理方法. CN: CN112614056A, 2021-04-06.

[5] 李栋, 张思微, 李迪. 一种荧光显微成像的系统. CN: CN112268879A, 2021-01-26.

[6] 李栋, 郭玉婷, 刘勇. 一种生物制样装置. CN: CN211877547U, 2020-11-06.

[7] 李栋, 郭玉婷, 刘勇. 一种生物制样装置及其制样方法. CN: CN110907252A, 2020-03-24.

[8] 李栋, 李迪. 一种结构光照明多焦面三维超分辨率成像系统. CN: CN110823372A, 2020-02-21.

[9] 李栋, 李迪. 一种激发光偏振高速调控装置. CN: CN110031959A, 2019-07-19.

[10] Betzig, Robert E., Li, Dong. Non-linear structured illumination microscopy. US: US10247672(B2), 2019-04-02.

[11] 李栋, 李迪, 张思微, 刘勇. 高速多色多模态结构光照明超分辨显微成像系统及其方法. CN: CN107389631A, 2017-11-24.

[12] Betzig Robert E., Li Dong. NON-LINEAR STRUCTURED ILLUMINATION MICROSCOPY. US: US20160305883A1, 2016-10-20.

[13] Betzig, Robert E., Li, Dong. NON-LINEAR STRUCTURED ILLUMINATION MICROSCOPY. US: US20160305883(A1), 2016-10-20.

出版信息

   
发表论文
[1] Amin Jiang, Siwei Zhang, Xinyu Wang, Dong Li. RBM15 condensates modulate m6A modification of STYK1 to promote tumorigenesis. Computational and Structural Biotechnology Journal[J]. 2022, 20: 4825-4836, http://dx.doi.org/10.1016/j.csbj.2022.08.068.

[2] Chang Qiao, Di Li, Yuting Guo, Chong Liu, Tao Jiang, Professor Qionghai Dai, Dong Li. Evaluation and development of image super-resolution deep neural networks for fluorescence microscopy (co-first authors, highlighted by Nature Methods). Nature Methods[J]. 2021, 
[3] Yang, Yanrui, Chen, Jiang, Chen, Xue, Li, Di, He, Jianfeng, Wang, Shen, Zhao, Shun, Yang, Xiaoyu, Deng, Shikun, Tong, Chunfang, Wang, Dou, Guo, Zhenzhen, Li, Dong, Ma, Cong, Liang, Xin, Shi, Yun S, Liu, JiaJia. Endophilin A1 drives acute structural plasticity of dendritic spines in response to Ca2+/calmodulin. JOURNAL OF CELL BIOLOGY[J]. 2021, 220(6): http://dx.doi.org/10.1083/jcb.202007172.

[4] Yang, Yihong, Li, Dong, Chao, Xiaoting, Singh, Shashi P, Thomason, Peter, Yan, Yonghong, Dong, Mengqiu, Li, Lei, Insall, Robert H, Cai, Huaqing. Leep1 interacts with PIP3 and the Scar/WAVE complex to regulate cell migration and macropinocytosis. JOURNAL OF CELL BIOLOGY[J]. 2021, 220(7): http://dx.doi.org/10.1083/jcb.202010096.

[5] Dong Li. 3D Structured Illumination Microscopy via Channel Attention Generative Adversarial Network. IEEE J SEL TOP QUANT. 2021, 
[6] 李栋. 时空超分辨率三维力示踪显微镜. Nano Letters. 2019, 
[7] 毕文婷, 翟玉梅, 孙强, 胡海岚, 江颖, 罗俊, 朱照宇, 覃重军, 聂广军, 傅向东, 常进, 李栋. 望得星空坐得板凳--“2018年度中国科学十大进展”主要完成人与《前沿科学》的独家对话. 前沿科学[J]. 2019, 13(1): 6-9, http://lib.cqvip.com/Qikan/Article/Detail?id=7001829933.

[8] 郭玉婷, 李迪, Siwei, Zhang, Yanrui, Yang, JiaJia, Liu, Xinyu, Wang, Chong, Liu, Daniel, EMilkie, Regan, PMoore, USerdar, Tulu, Daniel, PKiehart, Junjie, Hu, Jennifer, LippincottSchwartz, Eric, Betzig, 李栋. 纳米空间分辨率和毫秒时间尺度下观察细胞内细胞器和细胞骨架的互作. 科学新闻[J]. 2019, 39-39, http://lib.cqvip.com/Qikan/Article/Detail?id=75888869504849574850484956.

[9] 李栋. 超分辨率光学显微成像:揭示细胞器动态微观世界. 前沿科学[J]. 2019, 13(1): 40-43, http://lib.cqvip.com/Qikan/Article/Detail?id=7001829948.

[10] 王宏达, 李栋, 纪伟, 张名姝, 周正洪, 白丽, 储开芹, 张隆华, 孙育杰. 超高时空分辨蛋白质机器动态成像. 中国基础科学[J]. 2018, 20(1): 25-29, http://lib.cqvip.com/Qikan/Article/Detail?id=675432590.

[11] Ma, Ying, Li, Di, Smith, Zachary J, Li, Dong, Chu, Kaiqin. Structured illumination microscopy with interleaved reconstruction (SIMILR). JOURNAL OF BIOPHOTONICS[J]. 2018, 11(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000424643600021.

[12] Dong Li. Structured illumination microscopy with inter-leaved reconstruction (SIMILR). Journal of Biophotonics. 2017, 
[13] Beach, Jordan R, Shao, Lin, Remmert, Kirsten, Li, Dong, Betzig, Eric, Hammer, John A, III. Nonmuscle Myosin II Isoforms Coassemble in Living Cells. CURRENT BIOLOGY[J]. 2014, 24(10): 1160-1166, http://dx.doi.org/10.1016/j.cub.2014.03.071.

[14] Dong Li. Time-resolved detection enables standard two-photon fluorescence microscope for in vivo label-free imaging of microvasculature in tissue. Optics Letters. 2011, 
[15] Zheng, Wei, Li, Dong, Zeng, Yan, Luo, Yi, Qu, Jianan Y. Two-photon excited hemoglobin fluorescence. BIOMEDICAL OPTICS EXPRESS[J]. 2011, 2(1): 71-79, https://www.webofscience.com/wos/woscc/full-record/WOS:000299872300007.

[16] Li, Dong, Zheng, Wei, Zeng, Yan, Luo, Yi, Qu, Jianan Y. Two-photon excited hemoglobin fluorescence provides contrast mechanism for label-free imaging of microvasculature in vivo. OPTICS LETTERS[J]. 2011, 36(6): 834-836, https://www.webofscience.com/wos/woscc/full-record/WOS:000288322800020.

[17] Dong Li. In vivo and simultaneous multimodal imaging: integrated multiplex CARS and two-photon microscopy. Applied Physics Letters. 2010, 
[18] Li, Dong, Zheng, Wei, Qu, Jianan Y. Two-photon autofluorescence microscopy of multicolor excitation. OPTICS LETTERS[J]. 2009, 34(2): 202-204, https://www.webofscience.com/wos/woscc/full-record/WOS:000263217600029.

[19] Li, Dong, Zheng, Wei, Qu, Jianan Y. Imaging of epithelial tissue in vivo based on excitation of multiple endogenous nonlinear optical signals. OPTICS LETTERS[J]. 2009, 34(18): 2853-2855, https://www.webofscience.com/wos/woscc/full-record/WOS:000270114800052.

[20] Li, Dong, Zheng, Wei, Qu, Jianan Y. Time-resolved spectroscopic imaging reveals the fundamentals of cellular NADH fluorescence. OPTICS LETTERS[J]. 2008, 33(20): 2365-2367, http://dx.doi.org/10.1364/OL.33.002365.

科研活动

   
科研项目
( 1 ) 细胞分泌和降解相关膜行为的蛋白质机器, 参与, 国家级, 2016-07--2021-06
参与会议
(1)Pushing the envelope of super-resolution live imaging   Dong Li   2015-05-12
(2)Introduction to structured illumination microscopy and comparison between super resolution techniques   Dong Li   2015-05-08
(3)Extended resolution structured illumination imaging of dynamic process in living cells   Dong Li, Eric Betzig   2015-01-20
(4)Live cell SIM imaging and comparison between super-resolution techniques   Dong Li   2014-11-06
(5)Live cell structured illumination microscopy with enhanced resolution   Dong Li, Eric Betzig   2014-10-10
(6)Integrated multiplex CARS and two-photon fluorescence microscopy for imaging biological systems   Dong Li, Wei Zheng, Jianan Qu   2011-01-20
(7)Multicolor excitation two-photon microscopy: In vivo imaging of cells and tissues   Dong Li, Wei Zheng, Jianan Qu   2010-01-20

指导学生

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