基本信息
李栋  男  博导  中国科学院生物物理研究所
电子邮件: lidong@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码: 100101

招生信息

   
招生专业
071011-生物物理学
080300-光学工程
071009-细胞生物学
招生方向
研制光学显微活体成像技术,特别是超高分辨率技术,并探索其细胞生物学应用
探索先进显微镜技术的生物学应用
探索先进显微镜技术的生物学应用

教育背景

2006-08--2011-08   香港科技大学   博士,电子与计算机学系
2002-09--2006-06   浙江大学   学士,光电信息工程学系

工作经历

   
工作简历
2016-01~现在, 中国科学院生物物理研究所, 研究员,博导
2011-12~2015-12,霍华德休斯医学研究所,Janelia研究园, 博士后

专利与奖励

   
奖励信息
(1) PicoQuant青年研究员奖, 一等奖, 其他, 2015
(2) 香港青年科学家奖, 一等奖, 其他, 2011
(3) 浙江大学一等奖学金, 一等奖, 研究所(学校), 2005
(4) 浙江大学一等奖学金, 一等奖, 研究所(学校), 2004
专利成果
( 1 ) A system and method for dispersion compensation in optical coherence tomography, 发明, 2008, 第 2 作者, 专利号: CN1887220
( 2 ) Patterned activation structured illumination microscopy, 发明, 2015, 第 2 作者, 专利号: 62057220

出版信息

   
发表论文
[1] Di Li, Huw ColinYork, Liliana Barbieri, Yousef Javanmardi, Yuting Guo, Kseniya Korobchevskaya, Emad Moeendarbary, Dong Li, Marco Fritzsche. Astigmatic traction force microscopy (aTFM). NATURE COMMUNICATIONS[J]. 2021, 12(1): https://doaj.org/article/cc4958160dce4580b716a2a465783980.
[2] Xu, Guangju, Liu, Chong, Zhou, Sheng, Li, Quanjin, Feng, Yun, Sun, Panpan, Feng, Han, Gao, Yina, Zhu, Jingpeng, Luo, Xiu, Zhan, Qi, Liu, Songqing, Zhu, Shu, Deng, Hongyu, Li, Dong, Gao, Pu. Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion. MOLECULAR CELL[J]. 2021, 81(13): 2823-+, http://dx.doi.org/10.1016/j.molcel.2021.05.002.
[3] Liliana Barbieri, Huw ColinYork, Kseniya Korobchevskaya, Di Li, Deanna L Wolfson, Narain Karedla, Falk Schneider, Balpreet S Ahluwalia, Tore Seternes, Roy A Dalmo, Michael L Dustin, Dong Li, Marco Fritzsche. Two-dimensional TIRF-SIM-traction force microscopy (2D TIRF-SIM-TFM). NATURE COMMUNICATIONS[J]. 2021, 12(1): https://doaj.org/article/2749e6a50094452587f5c8033adf28f0.
[4] Qiao, Chang, Li, Di, Guo, Yuting, Liu, Chong, Jiang, Tao, Dai, Qionghai, Li, Dong. Evaluation and development of deep neural networks for image super-resolution in optical microscopy. NATURE METHODS[J]. 2021, 18(2): 194-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000609345700001.
[5] Gong, Bo, Guo, Yuting, Ding, Shihui, Liu, Xiaohui, Meng, Anming, Li, Dong, Jia, Shunji. A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission. NATURE CELL BIOLOGY[J]. 2021, 23(7): 782-+, http://dx.doi.org/10.1038/s41556-021-00704-y.
[6] Wang, Xinyu, Liu, Chong, Zhang, Siwei, Yan, Huiwen, Zhang, Liwen, Jiang, Amin, Liu, Yong, Feng, Yun, Li, Di, Guo, Yuting, Hu, Xinyao, Lin, Yajing, Bu, Pengcheng, Li, Dong. N-6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles. DEVELOPMENTAL CELL[J]. 2021, 56(5): 702-+, http://dx.doi.org/10.1016/j.devcel.2021.01.015.
[7] Dong Li. 3D Structured Illumination Microscopy via Channel Attention Generative Adversarial Network. 2021, [8] Jinshan Qin, Yuting Guo, Boxin Xue, Peng Shi, Yang Chen, Qian Peter Su, Huiwen Hao, Shujuan Zhao, Congying Wu, Li Yu, Dong Li, Yujie Sun. ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-18202-4.
[9] 李栋. 时空超分辨率三维力示踪显微镜. 2019, [10] Li, Dongfang, Zhao, Yan G, Li, Di, Zhao, Hongyu, Huang, Jie, Miao, Guangyan, Feng, Du, Liu, Pingsheng, Li, Dong, Zhang, Hong. The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation. CELL REPORTS[J]. 2019, 27(2): 343-+, http://dx.doi.org/10.1016/j.celrep.2019.03.025.
[11] Guo, Yuting, Li, Di, Zhang, Siwei, Yang, Yanrui, Liu, JiaJia, Wang, Xinyu, Liu, Chong, Milkie, Daniel E, Moore, Regan P, Tulu, U Serdar, Kiehart, Daniel P, Hu, Junjie, LippincottSchwartz, Jennifer, Betzig, Eric, Li, Dong. Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales. CELL[J]. 2018, 175(5): 1430-+, http://dx.doi.org/10.1016/j.cell.2018.09.057.
[12] Dong Li. Structured illumination microscopy with inter-leaved reconstruction (SIMILR). 2017, [13] Xiaofan Han, Pin Li, Zhenghao Yang, Xiaoshuai Huang, Guoqin Wei, Yujie Sun, Xuya Kang, Xueting Hu, Qiuping Deng, Liangyi Chen, Aibin He, Yingqing Huo, Dong Li, Eric Betzig, Jincai Luo. Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/76945a8838754779baa5979b1b9c124a.
[14] NixonAbell, Jonathon, Obara, Christopher J, Weigel, Aubrey V, Li, Dong, Legant, Wesley R, Xu, C Shan, Pasolli, H Amalia, Harvey, Kirsten, Hess, Harald F, Betzig, Eric, Blackstone, Craig, LippincottSchwartz, Jennifer. Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER. SCIENCE[J]. 2016, 354(6311): 433-+, [15] Zhang, Xi, Zhang, Mingshu, Li, Dong, He, Wenting, Peng, Jianxin, Betzig, Eric, Xu, Pingyong. Highly photostable, reversibly photoswitchable fluorescent protein with high contrast ratio for live-cell superresolution microscopy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2016, 113(37): 10364-10369, http://www.corc.org.cn/handle/1471x/2376269.
[16] Li, Dong, Betzig, Eric. Response to Comment on "Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics". SCIENCEnull. 2016, 352(6285): https://www.webofscience.com/wos/woscc/full-record/WOS:000374998600029.
[17] Li, Dong, Shao, Lin, Chen, BiChang, Zhang, Xi, Zhang, Mingshu, Moses, Brian, Milkie, Daniel E, Beach, Jordan R, Hammer, John A, III, Pasham, Mithun, Kirchhausen, Tomas, Baird, Michelle A, Davidson, Michael W, Xu, Pingyong, Betzig, Eric. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics. SCIENCE[J]. 2015, 349(6251): https://www.webofscience.com/wos/woscc/full-record/WOS:000360646800044.
[18] Beach, Jordan R, Shao, Lin, Remmert, Kirsten, Li, Dong, Betzig, Eric, Hammer, John A, III. Nonmuscle Myosin II Isoforms Coassemble in Living Cells. CURRENT BIOLOGY[J]. 2014, 24(10): 1160-1166, http://dx.doi.org/10.1016/j.cub.2014.03.071.
[19] Dong Li. Time-resolved detection enables standard two-photon fluorescence microscope for in vivo label-free imaging of microvasculature in tissue. 2011, [20] Zheng, Wei, Li, Dong, Zeng, Yan, Luo, Yi, Qu, Jianan Y. Two-photon excited hemoglobin fluorescence. BIOMEDICAL OPTICS EXPRESS[J]. 2011, 2(1): 71-79, https://www.webofscience.com/wos/woscc/full-record/WOS:000299872300007.
[21] Li, Dong, Zheng, Wei, Zeng, Yan, Luo, Yi, Qu, Jianan Y. Two-photon excited hemoglobin fluorescence provides contrast mechanism for label-free imaging of microvasculature in vivo. OPTICS LETTERS[J]. 2011, 36(6): 834-836, https://www.webofscience.com/wos/woscc/full-record/WOS:000288322800020.
[22] Dong Li. In vivo and simultaneous multimodal imaging: integrated multiplex CARS and two-photon microscopy. 2010, [23] Li, Dong, Zheng, Wei, Qu, Jianan Y. Two-photon autofluorescence microscopy of multicolor excitation. OPTICS LETTERS[J]. 2009, 34(2): 202-204, https://www.webofscience.com/wos/woscc/full-record/WOS:000263217600029.
[24] Li, Dong, Zheng, Wei, Qu, Jianan Y. Imaging of epithelial tissue in vivo based on excitation of multiple endogenous nonlinear optical signals. OPTICS LETTERS[J]. 2009, 34(18): 2853-2855, https://www.webofscience.com/wos/woscc/full-record/WOS:000270114800052.
[25] Li, Dong, Zheng, Wei, Qu, Jianan Y. Time-resolved spectroscopic imaging reveals the fundamentals of cellular NADH fluorescence. OPTICS LETTERS[J]. 2008, 33(20): 2365-2367, http://dx.doi.org/10.1364/OL.33.002365.

科研活动

   
科研项目
( 1 ) 细胞分泌和降解相关膜行为的蛋白质机器, 参与, 国家级, 2016-07--2021-06
参与会议
(1)Pushing the envelope of super-resolution live imaging   Dong Li   2015-05-12
(2)Introduction to structured illumination microscopy and comparison between super resolution techniques   Dong Li   2015-05-08
(3)Extended resolution structured illumination imaging of dynamic process in living cells   Dong Li, Eric Betzig   2015-01-20
(4)Live cell SIM imaging and comparison between super-resolution techniques   Dong Li   2014-11-06
(5)Live cell structured illumination microscopy with enhanced resolution   Dong Li, Eric Betzig   2014-10-10
(6)Integrated multiplex CARS and two-photon fluorescence microscopy for imaging biological systems   Dong Li, Wei Zheng, Jianan Qu   2011-01-20
(7)Multicolor excitation two-photon microscopy: In vivo imaging of cells and tissues   Dong Li, Wei Zheng, Jianan Qu   2010-01-20

指导学生

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