研究内容涵盖分析化学、生物化学、环境毒理等多学科，聚焦前沿的环境与健康科学问题，发展生命体内分子鉴定、检测、成像和调控的先进手段，突破复杂环境和生物体系中关键分子毒性和功能研究的技术瓶颈，并通过细胞和动物实验深入地研究环境污染物健康效应的分子机制。

欢迎对分析化学、环境科学、化学生物学、合成生物学、纳米材料等相关研究工作感兴趣的同学，一起来探索污染物的生命旅程，解析生命体内化学生物学过程，共同创造污染物与环境健康新知识。

2008. 09 - 2014.12，武汉大学化学与分子科学学院分析化学专业，博士
2011. 10 - 2013. 09，阿尔伯塔大学临床医学和病理学院环境分析与毒理系，联培博士生
2004. 09 – 2008. 07，武汉大学化学与分子科学学院化学基地班，学士

2021. 01 -至今，中国科学院生态环境研究中心，环境化学与生态毒理学国家重点实验室，研究员
2015. 01 -2020.12，阿尔伯塔大学临床医学和病理学院环境分析与毒理系，博士后

1. Le, X. C., Zhang, H. Q., Peng, H. Y., Li, X.-F. A microRNA-initiated DNAzyme motor operating in living cells. United States. PAT 86441-2, 2016/11/15.

2. Peng, H. Y., Zhang, H. Q., Li, X.-F., Le, X. C. Near-infrared photothermally activated CRISPR/Cas9 genome editing machine. United States. US 62/899,927. 2019/07/25

1. Peng, H. Y., Le, C., Wu, J. J., Li, X. -F., Zhang, H. Q., Le, X. C. A genome editing nanomachine constructed with a clustered regularly interspaced short palindromic repeats system and activated by near-Infrared illumination. ACS Nano 2020, 14, 2817–2826.

2. Wu, J. J.# , Peng, H. Y#. , Lu, X. F., Lai, M., Zhang, H. Q., Le, X. C. Binding-mediated formation of ribonucleoprotein corona for efficient delivery and control of CRISPR-Cas9. Angewandte Chemie International Edition 2020, doi.org/10.1002/anie.202014162. (Co-first authors)

3. Pang, B., Xu, J. Y., Liu, Y. M., Peng, H. Y., Feng, W., Cao, Y. R., Wu, J. J., Xiao, H. Y., Pabbaraju, K., Tipples, G., Joyce, M. A., Saffran, H. A., Tyrrell, D. L., Zhang, H. Q. and Le, X. C. Isothermal Amplification and Ambient Visualization in a Single Tube for the Detection of SARS-CoV-2 Using Loop-Mediated Amplification and CRISPR Technology, Analytical Chemistry 2020, 92, 16204–16212.

4. Feng, W.#, Newbigging, A. M.#, Le, C.#, Pang, B.#, Peng, H. Y.#, Cao, Y. Wu, J. J., Abbas, G., Song, J., Wang, D. -B. Cui, M., Tao, J., Tyrrell, D. L., Zhang, X. -E., Zhang, H. Q., Le, X. C. Molecular diagnosis of COVID-19: Challenges and research needs. Analytical Chemistry 2020, 92, 10196–10209. (Co-first authors, Cover feature)

5. Peng, H. Y., Newbigging, A., Reid, M. S., Uppal, J. S., Xu, J., Zhang, H., Le, X. C. Signal amplification in living cells: A review of microRNA detection and imaging. Analytical Chemistry 2020, 92, 292-308.

6. Huang, K., Peng, H. Y., Gao, F., Liu, Q. Q., Lu, X. -F., Shen, Q. R., Le, X. C., Zhao, F. J. Biotransformation of arsenic-containing Roxarsone by an aerobic soil bacterium Enterobacter sp. CZ-1. Environmental Pollution 2019, 247, 482-487.

7. Peng, H. Y., Newbigging, A., Wang, Z., Tao, J., Deng, W., Le, X. C., Zhang, H. Q. DNAzyme-mediated assays for amplified detection of nucleic acids and proteins. Analytical Chemistry 2018, 90, 190-207.

8. Peng, H. Y., Hu, B., Liu, Q. Q., Li, X. -F., Zhang, H. Q., Le, X. C. Methylated phenylarsenical metabolites discovered in chicken liver. Angewandte Chemie International Edition 2017, 56, 6773–6777. (Cover feature)

9. Peng, H. Y., Zhang, H., Li, X. -F., Le, X. C. A microRNA-initiated DNAzyme motor operating in living cells. Nature Communications 2017, 8, 14378. (Highly cited)

10. Yang, Z. L., Peng, H. Y., Lu, X. F., Liu, Q. Q. Huang, R. F., Hu, B., Kachanoski, G., Zuidhof, M. J., Le, X. C. Arsenic metabolites, including N-acetyl-4-hydroxy-m-arsanilic acid, in chicken litter from a roxarsone-feeding study involving 1600 chickens. Environmental Science & Technology 2016, 50, 6737-6743.

11. Liu, Q. Q., Peng, H. Y., Lu, X. F., Zuidhof, M. J., Li, X. -F., Le, X. C. Arsenic species in chicken breast: temporal variations of metabolites, elimination kinetics, and residual Concentrations. Environmental Health Perspectives 2016, 124, 1174-1181.

12. Peng, H. Y., Zhang, N., He, M., Chen, B. B., Hu, B. Multi-wall carbon nanotubes chemically modified silica microcolumn preconcentration/separation combined with inductively coupled plasma optical emission spectrometry for the determination of trace elements in environmental waters. International Journal of Environmental Analytical Chemistry 2016, 96, 212-224.

13. Yan, X. W., Li, J. H., Liu, Q. Q., Peng, H. Y. Popowich, A., Wang, Z. X., Li, X. -F., Le, X. C. p-Azidophenylarsenoxide: A novel arsenical “bait” for the in-situ capture and identification of cellular arsenic-binding proteins. Angewandte Chemie-International Edition 2016, 55, 14051-14057.

14. Zhang, H., Zuehlke, A., Peng, H. Y., Lai, M., Li, X. -F., Le, X. C. Binding-induced DNA nanomachines triggered by proteins and nucleic acids. Angewandte Chemie International Edition 2015, 54, 14326-14330.

15.Peng, H. Y., Reid, M. S., Le, X. C. Consumption of rice and fish in an electronic waste recycling area contributes significantly to tot al daily intake of mercury. Journal of Environmental Sciences 2015, 38, 83-86.

16. Peng, H. Y., Zhang, N., He, M., Chen, B. B., Hu, B. Simultaneous speciation analysis of inorganic arsenic, chromium and selenium in environmental waters by 3-(2-aminoethylamino) propyltrimethoxysilane modified multi-wall carbon nanotubes packed microcolumn solid phase extraction and ICP-MS. Talanta 2015, 131, 266–272. (Highly cited)

17. Peng, H. Y., Hu, B., Liu, Q. Q., Yang, Z. L., Lu, X., Huang, R. F., Li, X. -F., Le X. C. Liquid chromatography combined with atomic and molecular mass spectrometry for speciation of arsenic in chicken liver. Journal of Chromatography A 2014, 1370, 40–49.

18. Peng, H. Y., Jiao, Y., Xiao, X., Chen, B. B., He, M., Liu, Z. R., Zhang, X., Hu, B. Magnetic quantitative analysis for multiplex glycoprotein with polymer-based elemental tags. Journal of Analytical Atomic Spectrometry 2014, 29, 1112-1119.

19. Peng, H. Y., Chen, B. B., He, M., Zhang, Y., Hu, B. Magnetic quantitative immunoanalysis of carcinoembryonic antigen by ICP-MS with mercury labels. Journal of Analytical Atomic Spectrometry 2011, 26, 1217-1223.

20. Chen, B. B.#, Peng, H. Y.#, Zheng, F., Hu, B., He, M., Zhao, W., Pang, D. W. Immunoaffinity monolithic capillary microextraction coupled with ICP-MS for immunoassay with quantum dot labels. Journal of Analytical Atomic Spectrometry 2010, 25, 1674-1681. (Co-first authors, Cover feature)

21. Liu, Q. Q., Peng, H. Y. Popowich, A., Tao, J., Uppal, J. S., Yan, X., Beo, D., Le, X. C. Speciation of arsenic–a review of phenylarsenicals and related arsenic metabolites. TrAC Trends in Analytical Chemistry 2018, 104, 171-182.

22. Chen, J., Zuehlke, A., Deng, B., Peng, H. Y., Hou, X., Zhang, H. A target-triggered DNAzyme motor enabling homogeneous, amplified detection of proteins. Analytical Chemistry 2017, 89, 12888-12895.

23. Moe, B., Peng, H.Y., Lu, X. F., Chen, B.W., Chen, L.W.L., Gabos, S., Li, X. -F., Le, X. C. Comparative cytotoxicity of fourteen trivalent and pentavalent arsenic species determined using real-time cell sensing. Journal of Environmental Sciences 2016, 49, 113-124.

24. Liu, Q.Q., Peng, H. Y., Lu X., Le, X. C. Enzyme-assisted extraction and liquid chromatography mass spectrometry for the determination of arsenic species in chicken meat. Analytica Chimica Acta 2015, 888, 1-9. (Cover feature)

担任AC、J. Environ. Sci.、E&H、环境化学、高等学校化学学报、Biosensors、IJERPH等期刊青年编委

环境分析化学与健康，国家高层次人才海外项目，主持，2022-2024

面上项目，主持，2023-2026

企业技术开发项目，主持，2022-2027

科技部重点研发项目，专题负责人，2023-2026