1. 精原干细胞（SSCs）增殖、分化（减数分裂）以及去分化（重编程）研究。我们已经建立了精原干细胞的体外培养扩增以及多能性干细胞诱导形成生殖细胞的平台，为发展基于人工诱导生殖细胞的不育治疗技术奠定了基础。未来将面向男性不育治疗的应用目标，快速推进在体外获得“人造”精子的工作。 

　　2. 精子发生的表观遗传调控机理。我们已经利用分离纯化的多种生精细胞结合组学技术，在DNA、RNA、蛋白质三个水平绘制哺乳动物精子发生基因调控的全局视图，利用基因敲除和分子生物学技术重点研究关键转录因子在精子发生中的功能，为男性不育的诊断提供了候选基因。未来我们将继续利用组学技术研究在生殖细胞形成和发育过程中基因表观遗传修饰的变化以及RNA和蛋白质的表达变化，发现对分化起关键作用的基因，并针对其作用机理设计出更加有效的体外分化诱导方案，为临床转化奠定基础。

   

071008-发育生物学
071009-细胞生物学
071010-生物化学与分子生物学

精原干细胞，多能干细胞
基因组学及蛋白质组学

1993-09--2000-05 密苏里大学生物化学系 博士
1990-09--1993-05 中国科学院动物研究所生殖生物学国家重点实验室生殖生理学专业 硕士
1986-09--1990-05 复旦大学生物工程系遗传专业 学士

-- 研究生

-- 博士

   

2003-12--今 中国科学院动物研究所生殖生物学国家重点实验室 研究员
2000-09--2013-11 美国Lexicon制药公司 高级生物信息学科学家

2018-11-14-2019-10-31,Biology of Reproduction Board of Reviewing Editors, Board Member

生殖生物学、 生物信息学应用、 生物信息学

   

[1] 韩春生, 王杨, 刘元, 宋雪. Stra8基因定点敲入报告基因的精原干细胞构建方法及其应用. CN: CN116536273A, 2023-08-04.

   

[1] Han, Chunsheng. Gene expression programs in mammalian spermatogenesis. DEVELOPMENT. 2024, 第 1 作者  通讯作者  151(8): http://dx.doi.org/10.1242/dev.202033.
[2] Ning, Yan, Duo, Shuguang, Lin, Xiwen, Zhang, Hongbo, Fei, Jifeng, Zhang, Bao, Zeng, Yanyun, Xie, Dan, Chen, Jian, Liu, Xiaowei, Han, Chunsheng. Transcription factor PBX4 regulates limb development and haematopoiesis in mice. CELL PROLIFERATION[J]. 2024, 第 11 作者  通讯作者  57(5): http://dx.doi.org/10.1111/cpr.13580.
[3] Chen, Jian, Han, Chunsheng. In vivo functions of miRNAs in mammalian spermatogenesis. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2023, 第 2 作者  通讯作者  11: http://dx.doi.org/10.3389/fcell.2023.1154938.
[4] Liu, PeiPei, Lu, ShiPing, Li, Xiao, Tang, GangBin, Liu, Xiao, Dai, ShangKun, Jiao, LinFei, Lin, XiWen, Li, XingGuo, Hu, Baoyang, Jiao, Jianwei, Teng, ZhaoQian, Han, ChunSheng, 刘长梅. Abnormal chromatin remodeling caused by ARID1A deletion leads to malformation of the dentate gyrus. CELL DEATH AND DIFFERENTIATION[J]. 2023, 第 13 作者  通讯作者  http://dx.doi.org/10.1038/s41418-023-01199-w.
[5] 李佳宇, 韩春生. A CRISPR/Cas9-based kinome screen identifies ErbB signaling as a new regulator of human naïve pluripotency and totipotency. Life Medicine[J]. 2023, 第 2 作者  通讯作者  
[6] 闫琳, 陈建, 宁岩, 韩春生. RBFOX2 缺失抑制雄性小鼠的减数分裂起始. 生物工程学报[J]. 2023, 第 4 作者  通讯作者  
[7] Lu, Cuiling, Qin, Caimeng, Fu, Zheng, Wang, Lina, Yi, Yanxiao, Xin, Mingwei, Zhen, Xiumei, Han, Chunsheng. Metabolic dysregulation in patients with premature ovarian insufficiency revealed by integrated transcriptomic, methylomic and metabolomic analyses. CLINICAL AND TRANSLATIONAL MEDICINE[J]. 2022, 第 8 作者  通讯作者  12(10): https://www.doi.org/10.1002/ctm2.1006.
[8] Chen, Jian, Gao, Chenxu, Luo, Mengcheng, Zheng, Chunwei, Lin, Xiwen, Ning, Yan, Ma, Longfei, He, Wei, Xie, Dan, Liu, Kui, Hong, Kai, Han, Chunsheng. MicroRNA-202 safeguards meiotic progression by preventing premature SEPARASE-mediated REC8 cleavage. EMBO REPORTS[J]. 2022, 第 12 作者  通讯作者  23(8): https://www.doi.org/10.15252/embr.202154298.
[9] Ma, Longfei, Xie, Dan, Luo, Mengcheng, Lin, Xiwen, Nie, Hengyu, Chen, Jian, Gao, Chenxu, Duo, Shuguang, Han, Chunsheng. Identification and characterization of BEND2 as a key regulator of meiosis during mouse spermatogenesis. SCIENCE ADVANCES[J]. 2022, 第 9 作者  通讯作者  8(21): http://dx.doi.org/10.1126/sciadv.abn1606.
[10] Li, Miao, Zheng, Jiahuan, Li, Gaopeng, Lin, Zexiong, Li, Dongliang, Liu, Dongteng, Feng, Haiwei, Cao, Dandan, Ng, Ernest H Y, Li, Raymond H W, Han, Chunsheng, Yeung, William S B, Chow, Louise T, Wang, Hengbin, Liu, Kui. The male germline-specific protein MAPS is indispensable for pachynema progression and fertility. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2021, 第 11 作者118(8): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923350/.
[11] Dong, Fangfang, Chen, Min, Chen, Min, Jiang, Lin, Shen, Zhiming, Ma, Longfei, Han, Chunsheng, Guo, Xudong, Gao, Fei. PRMT5 Is Involved in Spermatogonial Stem Cells Maintenance by Regulating Plzf Expression via Modulation of Lysine Histone Modifications. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2021, 第 7 作者  通讯作者  9: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185031/.
[12] Chen, Jian, Gao, Chenxu, Lin, Xiwen, Ning, Yan, He, Wei, Zheng, Chunwei, Zhang, Daoqin, Yan, Lin, Jiang, Binjie, Zhao, Yuting, Hossen, Md Alim, Han, Chunsheng. The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis. DEVELOPMENT[J]. 2021, 第 12 作者  通讯作者  148(24): http://dx.doi.org/10.1242/dev.199799.
[13] Luo, Zhengyu, Wang, Xiaorong, Jiang, Hong, Wang, Ruoyu, Chen, Jian, Chen, Yusheng, Xu, Qianlan, Cao, Jun, Gong, Xiaowen, Wu, Ji, Yang, Yungui, Li, Wenbo, Han, Chunsheng, Cheng, C Yan, Rosenfeld, Michael G, Sun, Fei, Song, Xiaoyuan. Reorganized 3D Genome Structures Support Transcriptional Regulation in Mouse Spermatogenesis. ISCIENCE[J]. 2020, 第 13 作者23(4): https://doaj.org/article/72a3812777ad4f4483c16dabaca76593.
[14] Gao, Hongying, Zheng, Chunwei, Du, Jian, Wu, Yue, Sun, Yonghui, Han, Chunsheng, Kee, Kehkooi, Rao, Yu. FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice. PROTEIN & CELL[J]. 2020, 第 6 作者  通讯作者  11(7): 534-539, http://lib.cqvip.com/Qikan/Article/Detail?id=7102619529.
[15] Zheng, Chunwei, Ouyang, YingChun, Jiang, Binjie, Lin, Xiwen, Chen, Jian, Dong, MingZhe, Zhuang, Xinjie, Yuan, Shuiqiao, Sun, QingYuan, Han, Chunsheng. Non-canonical RNA polyadenylation polymerase FAM46C is essential for fastening sperm head and flagellum in mice. BIOLOGY OF REPRODUCTION[J]. 2019, 第 10 作者  通讯作者  100(6): 1673-1685, http://dx.doi.org/10.1093/biolre/ioz083.
[16] Li, Miao, Huang, Tao, Li, MengJing, Zhang, ChuanXin, Yu, XiaoChen, Yin, YingYing, Liu, Chao, Wang, Xin, Feng, HaiWei, Zhang, Tuo, Liu, MoFang, Han, ChunSheng, Lu, Gang, Li, Wei, Ma, JinLong, Chen, ZiJiang, Liu, HongBin, Liu, Kui. The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice. SCIENCE ADVANCES[J]. 2019, 第 12 作者5(8): http://dx.doi.org/10.1126/sciadv.aax1101.
[17] Feng, Yanmin, Ning, Yan, Lin, Xiwen, Zhang, Daoqin, Liao, Shangying, Zheng, Chunwei, Chen, Jian, Wang, Yang, Ma, Longfei, Xie, Dan, Han, Chunsheng. Reprogramming p53-Deficient Germline Stem Cells Into Pluripotent State by Nanog. STEM CELLS AND DEVELOPMENT[J]. 2018, 第 11 作者  通讯作者  27(10): 692-703, http://dx.doi.org/10.1089/scd.2018.0047.
[18] Zhang, Daoqin, Xie, Dan, Lin, Xiwen, Ma, Longfei, Chen, Jian, Zhang, Daoqi, Wang, Yang, Duo, Shuguang, Feng, Yanmin, Zheng, Chunwei, Jiang, Binjie, Ning, Yan, Han, Chunsheng. The transcription factor SOX30 is a key regulator of mouse spermiogenesis. DEVELOPMENT[J]. 2018, 第 13 作者  通讯作者  145(11): http://dx.doi.org/10.1242/dev.164723.
[19] Chen, Min, Zhang, Lianjun, Cui, Xiuhong, Lin, Xiwen, Li, Yaqiong, Wang, Yaqing, Wang, Yanbo, Qin, Yan, Chen, Dahua, Han, Chunsheng, Zhou, Bin, Huff, Vicki, Gao, Fei. Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression. DEVELOPMENT[J]. 2017, 第 10 作者144(1): 44-53, https://www.webofscience.com/wos/woscc/full-record/WOS:000393454900008.
[20] Liu, Pinglei, Liu, Kun, Gu, Haifeng, Wang, Weixu, Gong, Jiaqi, Zhu, Yingjie, Zhao, Qian, Cao, Jiani, Han, Chunseng, Gao, Fei, Chen, Quan, Li, Wei, Jiao, Jianwei, Hu, Baoyang, Zhou, Qi, Zhao, Tongbiao. High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1. CELL DEATH AND DIFFERENTIATION[J]. 2017, 24(10): 1672-1680, http://dx.doi.org/10.1038/cdd.2017.90.
[21] Chen, Jian, Cai, Tanxi, Zheng, Chunwei, Lin, Xiwen, Wang, Guojun, Liao, Shangying, Wang, Xiuxia, Gan, Haiyun, Zhang, Daoqin, Hu, Xiangjing, Wang, Si, Li, Zhen, Feng, Yanmin, Yang, Fuquan, Han, Chunsheng. MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins. NUCLEIC ACIDS RESEARCH[J]. 2017, 第 15 作者  通讯作者  45(7): 4142-4157, http://dx.doi.org/10.1093/nar/gkw1287.
[22] Tu, Zhaowei, Bayazit, Mustafa Bilal, Liu, Hongbin, Zhang, Jingjing, Busayavalasa, Kiran, Risal, Sanjiv, Shao, Jingchen, Satyanarayana, Ande, Coppola, Vincenzo, Tessarollo, Lino, Singh, Meenakshi, Zheng, Chunwei, Han, Chunsheng, Chen, Zijiang, Kaldis, Philipp, Gustafsson, JanAke, Liu, Kui. Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 第 13 作者114(3): 592-597, http://dx.doi.org/10.1073/pnas.1618465114.
[23] ZhaoWei Tu, Mustafa Bilal Bayazit, HongBin Liu, JingJing Zhang, Kiran Busayavalasa, Sanjiv Risal, JingChen Shao, Ande Satyanarayana, Vincenzo Coppola, Lino Tessarollo, Meenakshi Singh, 郑春伟, 韩春生, ZiJiang Chen, Philipp Kaldis, Janke Gustafsson, 刘奎. Speedy A-Cdk2 Binding Mediates Initial Telomere-Nuclear Envelope Attachment During Meiotic Prophase I Independent of Cdk2 Activation. PNAS[J]. 2017, 第 13 作者114(3): 592-597, http://ir.ioz.ac.cn/handle/000000/12823.
[24] Hu, Xiangjing, Shen, Bin, Liao, Shangying, Ning, Yan, Ma, Longfei, Chen, Jian, Lin, Xiwen, Zhang, Daoqin, Li, Zhen, Zheng, Chunwei, Feng, Yanmin, Huang, Xingxu, Han, Chunsheng. Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint. CELL DEATH & DISEASE[J]. 2017, 第 13 作者  通讯作者  8(6): e2910, http://dx.doi.org/10.1038/cddis.2017.228.
[25] 尚永丰. Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis. MOLECULAR CELL[J]. 2017, 67(5): 853-+, http://dx.doi.org/10.1016/j.molcel.2017.07.011.
[26] Yang, Yongguang, Feng, Yanmin, Feng, Xue, Liao, Shangying, Wang, Xiuxia, Gan, Haiyun, Wang, Lixian, Lin, Xiwen, Han, Chunsheng. BMP4 Cooperates with Retinoic Acid to Induce the Expression of Differentiation Markers in Cultured Mouse Spermatogonia. STEM CELLS INTERNATIONAL[J]. 2016, 第 9 作者  通讯作者  2016: https://doaj.org/article/d63018c1aae748daba5d8de9326fc569.
[27] Yu Xue, Eric-Wubbo Lameijer, Kai Ye, Kunlin Zhang, Suhua Chang, Xiaoyue Wang, Jianmin Wu, Ge Gao, Fangqing Zhao, Jian Li, Chunsheng Han, Shuhua Xu, Jingfa Xiao, Xuerui Yang, Xiaomin Ying, Xuegong Zhang, Wei-Hua Chen, Yun Liu, Zhang Zhang, Kun Huang, Jun Yu. Precision Medicine: What Challenges Are We Facing?. 基因组蛋白质组与生物信息学报：英文版[J]. 2016, 第 11 作者14(5): 253-261, http://lib.cqvip.com/Qikan/Article/Detail?id=670500851.
[28] Wu, Yujian, Hu, Xiangjing, Li, Zhen, Wang, Min, Li, Sisi, Wang, Xiuxia, Lin, Xiwen, Liao, Shangying, Zhang, Zhuqiang, Feng, Xue, Wang, Si, Cui, Xiuhong, Wang, Yanling, Gao, Fei, Hess, Rex A, Han, Chunsheng. Transcription Factor RFX2 Is a Key Regulator of Mouse Spermiogenesis. SCIENTIFIC REPORTS[J]. 2016, 第 16 作者  通讯作者  6: http://dx.doi.org/10.1038/srep20435.
[29] Lin, Xiwen, Han, Miao, Cheng, Lu, Chen, Jian, Zhang, Zhuqiang, Shen, Ting, Wang, Min, Wen, Bo, Ni, Ting, Han, Chunsheng. Expression dynamics, relationships, and transcriptional regulations of diverse transcripts in mouse spermatogenic cells. RNA BIOLOGY[J]. 2016, 第 10 作者  通讯作者  13(10): 1011-1024, http://dx.doi.org/10.1080/15476286.2016.1218588.
[30] Wang, Si, Wang, Xiuxia, Ma, Longfei, Lin, Xiwen, Zhang, Daoqin, Li, Zhen, Wu, Yujian, Zheng, Chunwei, Feng, Xue, Liao, Shangying, Feng, Yanmin, Chen, Jian, Hu, Xiangjing, Wang, Min, Han, Chunsheng. Retinoic Acid Is Sufficient for the In Vitro Induction of Mouse Spermatocytes. STEM CELL REPORTS[J]. 2016, 第 15 作者  通讯作者  7(1): 80-94, https://doaj.org/article/5694953446cc4e4b9d23e6faccb93e12.
[31] Gao, Yanyan, Bai, Xiufeng, Zhang, Dejiu, Han, Chunsheng, Yuan, Jing, Liu, Wenbin, Cao, Xintao, Chen, Zilei, Shangguan, Fugen, Zhu, Zhenyuan, Gao, Fei, Qin, Yan. Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2016, 第 4 作者23(5): 441-449, https://www.webofscience.com/wos/woscc/full-record/WOS:000375633100016.
[32] Wang, Si, Wang, Xiuxia, Wu, Yujian, Han, Chunsheng. IGF-1R Signaling Is Essential for the Proliferation of Cultured Mouse Spermatogonial Stem Cells by Promoting the G(2)/M Progression of the Cell Cycle. STEM CELLS AND DEVELOPMENT[J]. 2015, 第 4 作者  通讯作者  24(4): 471-483, http://dx.doi.org/10.1089/scd.2014.0376.
[33] Zhu, Liang, Han, ChunSheng, Cao, ZeLei, Wang, ZhenBo, Han, RuiGang, Wang, Bing, Sun, QingYuan. Confocal Microscopic Analysis of the Spindle and Chromosome Configurations of in vitro-Matured Oocytes from Different Types of Polycystic Ovary Syndrome Patients. GYNECOLOGIC AND OBSTETRIC INVESTIGATION[J]. 2015, 第 2 作者80(3): 179-186, https://www.webofscience.com/wos/woscc/full-record/WOS:000363830900006.
[34] Li, Yangfang, Wang, Xiuxia, Feng, Xue, Liao, Shangying, Zhang, Daoqin, Cui, Xiuhong, Gao, Fei, Han, Chunsheng. Generation of male germ cells from mouse induced pluripotent stem cells in vitro. STEM CELL RESEARCH[J]. 2014, 第 8 作者  通讯作者  12(2): 517-530, https://doaj.org/article/4684ec2d617a462489ff001ad9c67471.
[35] Li, Sisi, Wang, Yongqing, Cao, Bin, Wu, Yujian, Ji, Lei, Li, Yuxia, Liu, Ming, Zhao, Yangyu, Qiao, Jie, Wang, Haibing, Wang, Hongmei, Han, Chunsheng, Wang, Yanling. Maturation of Growth Differentiation Factor 15 in Human Placental Trophoblast Cells Depends on the Interaction With Matrix Metalloproteinase-26. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM[J]. 2014, 第 12 作者99(11): E2277-E2287, https://www.webofscience.com/wos/woscc/full-record/WOS:000346743100070.
[36] Han, Chunsheng. Which one is the real matchmaker for the pair?. ASIAN JOURNAL OF ANDROLOGY[J]. 2014, 第 1 作者  通讯作者  16(5): 667-668, http://lib.cqvip.com/Qikan/Article/Detail?id=663374902.
[37] Wu, Yujian, Liao, Shangying, Wang, Xiuxia, Wang, Si, Wang, Min, Han, Chunsheng. HSF2BP represses BNC1 transcriptional activity by sequestering BNC1 to the cytoplasm. FEBS LETTERS[J]. 2013, 第 6 作者  通讯作者  587(14): 2099-2104, http://dx.doi.org/10.1016/j.febslet.2013.04.049.
[38] Wang Fengli, Yang Yeran, Lin Xiwen, Wang JiuQiang, Wu YongSheng, Xie Wenjuan, Wang Dandan, Zhu Shu, Liao YouQi, Sun Qinmiao, Yang YunGui, Luo HuaiRong, Guo Caixia, Han Chunsheng, Tang TieShan. Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington’s disease.. HUMAN MOLECULAR GENETICS. 2013, 第 14 作者http://www.irgrid.ac.cn/handle/1471x/730359.
[39] Gan, Haiyun, Cai, Tanxi, Lin, Xiwen, Wu, Yujian, Wang, Xiuxia, Yang, Fuquan, Han, Chunsheng. Integrative Proteomic and Transcriptomic Analyses Reveal Multiple Post-transcriptional Regulatory Mechanisms of Mouse Spermatogenesis. MOLECULAR & CELLULAR PROTEOMICS[J]. 2013, 第 7 作者  通讯作者  12(5): 1144-1157, http://dx.doi.org/10.1074/mcp.M112.020123.
[40] Wang, Fengli, Yang, Yeran, Lin, Xiwen, Wang, JiuQiang, Wu, YongSheng, Xie, Wenjuan, Wang, Dandan, Zhu, Shu, Liao, YouQi, Sun, Qinmiao, Yang, YunGui, Luo, HuaiRong, Guo, Caixia, Han, Chunsheng, Tang, TieShan. Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntingtons disease. HUMANMOLECULARGENETICS[J]. 2013, 第 14 作者22(18): 3641-3653, http://www.irgrid.ac.cn/handle/1471x/730359.
[41] Ji, ShaoYang, Hao, JianXiu, Li, Lei, Zhang, Jun, Zheng, QiaoSong, Li, XiXia, Wang, XiaoNa, Han, ChunSheng, Gao, Fei, Liu, YiXun. Expression of Inhibin-Alpha Is Regulated Synergistically by Wilms' Tumor Gene 1 (Wt1) and Steroidogenic Factor-1 (Sf1) in Sertoli Cells. PLOS ONE[J]. 2013, 第 8 作者8(1): https://doaj.org/article/c63190a431774775a18beec9207bd046.
[42] Yang Yungui. Whole Genome-wide Loss of 5-hmC is a Novel Epigenetic Feature of Huntington’s Disease. Hum Mol Genet. 2013, 
[43] Gan, Haiyun, Wen, Lu, Liao, Shangying, Lin, Xiwen, Ma, Tingting, Liu, Jun, Song, Chunxiao, Wang, Min, He, Chuan, Han, Chunsheng, Tang, Fuchou. Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis. NATURE COMMUNICATIONS[J]. 2013, 第 10 作者  通讯作者  4: http://dx.doi.org/10.1038/ncomms2995.
[44] Yu, Bing, He, ZhiYing, You, Pu, Han, QingWang, Xiang, Dao, Chen, Fei, Wang, MinJun, Liu, ChangCheng, Lin, XiWen, Borjigin, Uyunbilig, Zi, XiaoYuan, Li, JianXiu, Zhu, HaiYing, Li, WenLin, Han, ChunSheng, Wangensteen, Kirk J, Shi, Yufang, Hui, LiJian, Wang, Xin, Hu, YiPing. Reprogramming Fibroblasts into Bipotential Hepatic Stem Cells by Defined Factors. CELL STEM CELL[J]. 2013, 第 15 作者13(3): 328-340, http://dx.doi.org/10.1016/j.stem.2013.06.017.
[45] Shi, YuQiang, Zhuang, XinJie, Xu, Bo, Hua, Juan, Liao, ShangYing, Shi, Qinghua, Cooke, Howard J, Han, Chunsheng. SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60. GENE[J]. 2013, 第 8 作者527(1): 352-359, http://dx.doi.org/10.1016/j.gene.2013.06.033.
[46] Peng, Hongying, Shi, Junchao, Zhang, Ying, Zhang, He, Liao, Shangying, Li, Wei, Lei, Li, Han, Chunsheng, Ning, Lina, Cao, Yujing, Zhou, Qi, Chen, Qi, Duan, Enkui. A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm. CELL RESEARCH[J]. 2012, 第 8 作者22(11): 1609-1612, https://www.webofscience.com/wos/woscc/full-record/WOS:000310789500014.
[47] Hou, Xiaojun, Zhang, Wei, Xiao, Zhenyu, Gan, Haiyun, Lin, Xiwen, Liao, Shangying, Han, Chunsheng. Mining and characterization of ubiquitin E3 ligases expressed in the mouse testis. BMC GENOMICS[J]. 2012, 第 7 作者  通讯作者  13(1): 495-495, http://dx.doi.org/10.1186/1471-2164-13-495.
[48] Zhang, Yan, Wang, Si, Wang, Xiuxia, Liao, Shangying, Wu, Yujian, Han, Chunsheng. Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells. CELL RESEARCH[J]. 2012, 第 6 作者  通讯作者  22(4): 773-776, http://lib.cqvip.com/Qikan/Article/Detail?id=41470966.
[49] Yan Zhang, Si Wang, Xiuxia Wang, Shangying Liao, Yujian Wu, Chunsheng Han. Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells. 细胞研究：英文版[J]. 2012, 第 6 作者22(4): 773-776, http://lib.cqvip.com/Qikan/Article/Detail?id=41470966.
[50] Liu, Zhaoting, Lin, Xiwen, Cai, Zhaoping, Zhang, Zhuqiang, Han, Chunsheng, Jia, Shunji, Meng, Anming, Wang, Qiang. Global Identification of SMAD2 Target Genes Reveals a Role for Multiple Co-regulatory Factors in Zebrafish Early Gastrulas. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2011, 第 5 作者286(32): 28520-28532, http://dx.doi.org/10.1074/jbc.M111.236307.
[51] Zhuang, Xinjie, Hou, Xiaojun, Liao, ShangYing, Wang, XiuXia, Cooke, Howard J, Zhang, Ming, Han, Chunsheng. SLXL1, a Novel Acrosomal Protein, Interacts with DKKL1 and Is Involved in Fertilization in Mice. PLOS ONE[J]. 2011, 第 7 作者6(6): https://doaj.org/article/3b5d5c3aca8d4e3baefafdd3e52c8df2.
[52] Liu, Hong, Wang, Bo, Han, Chunsheng. Meta-Analysis of Genome-Wide and Replication Association Studies on Prostate Cancer. PROSTATE[J]. 2011, 第 3 作者  通讯作者  71(2): 209-224, https://www.webofscience.com/wos/woscc/full-record/WOS:000286857500009.
[53] Gan, Haiyun, Lin, Xiwen, Zhang, Zhuqiang, Zhang, Wei, Liao, Shangying, Wang, Lixian, Han, Chunsheng. piRNA profiling during specific stages of mouse spermatogenesis. RNA[J]. 2011, 第 7 作者  通讯作者  17(7): 1191-1203, https://www.webofscience.com/wos/woscc/full-record/WOS:000291683500001.
[54] Shi, YuQiang, Liao, ShangYing, Zhuang, XinJie, Han, ChunSheng. Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37. GENE[J]. 2011, 第 4 作者  通讯作者  485(2): 153-159, http://dx.doi.org/10.1016/j.gene.2011.06.025.
[55] Jinsong Zhang, Qiang Liu, Wei Zhang, Jianyuan Li, Zheng Li, Zhongyi Tang, Yixue Li, Chunsheng Han, Susan H. Hall, Yonglian Zhang. Comparative profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides. 生物化学与生物物理学报：英文版[J]. 2010, 第 8 作者145-153, http://lib.cqvip.com/Qikan/Article/Detail?id=33232764.
[56] Yang, Yongguang, Han, Chunsheng. GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway. BMC CELL BIOLOGY[J]. 2010, 第 2 作者  通讯作者  11(1): https://doaj.org/article/4682d17074ff40139fcdef5cae24045d.
[57] Jinsong Zhang, Qiang Liu, Wei Zhang, Jianyuan Li, Zheng Li, Zhongyi Tang, Yixue Li, Chunsheng Han, Susan H Hall, Yonglian Zhang. Comparative profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides. Acta Biochimica et Biophysica Sinica[J]. 2010, 第 8 作者42(2): 145-153, https://www.sciengine.com/doi/10.1093/abbs/gmp116.
[58] Shi, YuQiang, Li, YinChuan, Hu, XiaoQian, Liu, Tao, Liao, ShangYing, Guo, Jian, Huang, Lin, Hu, ZhaoYuan, Tang, Alan Y B, Lee, KaiFai, Yeung, William S B, Han, ChunSheng, Liu, YiXun. Male germ cell-specific protein Trs4 binds to multiple proteins. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2009, 第 12 作者  通讯作者  388(3): 583-588, https://www.webofscience.com/wos/woscc/full-record/WOS:000275061900022.
[59] Hong Nian, Wei Zhang, Hexin Shi, Qingzhen Zhao, Qi Xie, Shangying Liao, Yan Zhang, Zhuqiang Zhang, Chen Wang, Chunsheng Han. Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase. 细胞研究：英文版[J]. 2008, 第 10 作者18(7): 800-802, http://lib.cqvip.com/Qikan/Article/Detail?id=27833381.
[60] Nian, Hong, Zhang, Wei, Shi, Hexin, Zhao, Qingzhen, Xie, Qi, Liao, Shangying, Zhang, Yan, Zhang, Zhuqiang, Wang, Chen, Han, Chunsheng. Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase. CELL RESEARCH[J]. 2008, 第 10 作者18(7): 800-802, http://lib.cqvip.com/Qikan/Article/Detail?id=27833381.
[61] 王庆忠, 韩春生. KnockoutTM SR无血清培养基支持小鼠精原干细胞的短期存活. 分子细胞生物学报[J]. 2008, 第 2 作者41(2): 162-166, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=3244983&detailType=1.
[62] 王庆忠, 韩春生. Knockout^TM SR无血清培养基支持小鼠精原干细胞的短期存活（简报）. 分子细胞生物学报[J]. 2008, 第 2 作者41(2): 162-166, http://lib.cqvip.com/Qikan/Article/Detail?id=27254034.
[63] Nian, Hong, Fan, Cuihong, Liao, Shangying, Shi, Yuqiang, Zhang, Keying, Liu, Yixun, Han, Chunsheng. RNF151, a testis-specific RING finger protein, interacts with dysbindin. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS[J]. 2007, 第 7 作者  通讯作者  465(1): 157-163, https://www.webofscience.com/wos/woscc/full-record/WOS:000249176400018.
[64] Zhang, Keying, Shang, Yingli, Liao, Shangying, Zhang, Wei, Nian, Hong, Liu, Yixun, Chen, Quan, Han, Chunsheng. Uncoupling protein 2 protects testicular germ cells from hyperthermia-induced apoptosis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2007, 第 8 作者  通讯作者  360(2): 327-332, https://www.webofscience.com/wos/woscc/full-record/WOS:000248159000005.
[65] 韩春生. DNA芯片与蛋白质质谱技术在生殖内分泌研究中的应用. 中华妇产科杂志[J]. 2006, 第 1 作者41(6): 361-363, http://lib.cqvip.com/Qikan/Article/Detail?id=22330258.
[66] Li, YinChuan, Hu, XiaoQian, Zhang, KeYing, Guo, Han, Hu, ZhaoYuan, Tao, ShiXin, Xiao, LiJuan, Wang, QingZhong, Han, ChunSheng, Liu, YiXun. Afaf, a novel vesicle membrane protein, is related to acrosome formation in murine testis. FEBS LETTERS[J]. 2006, 第 9 作者580(17): 4266-4273, http://dx.doi.org/10.1016/j.febslet.2006.06.010.
[67] WANG Qingzhong, LIU Yixun, HAN Chunsheng. The molecular mechanism of embryonic stem cell pluripotency maintenance. 中国科学通报：英文版[J]. 2005, 第 3 作者50(19): 2121-2131, http://lib.cqvip.com/Qikan/Article/Detail?id=20534511.
[68] 王庆忠, 刘以训, 韩春生. 胚胎干细胞多潜能性维持的分子机制. 科学通报[J]. 2005, 第 3 作者50(15): 1556-1566, http://lib.cqvip.com/Qikan/Article/Detail?id=20102519.
[69] 韩春生, 张志文, 杨新林, 庄临之. 妊娠早期人滋养层组织中抑制素α和β亚基mRNA的表达. 科学通报[J]. 1995, 第 1 作者40(20): 1917, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=275446&detailType=1.

   

（ 1 ） 多能干细胞向生殖细胞分化模型及调控机制, 主持, 国家级, 2012-01--2016-12
（ 2 ） 原始生殖细胞特化和定向迁移, 主持, 国家级, 2013-01--2017-12
（ 3 ） 小鼠中来源于mRNA的piRNA的生成机理研究, 主持, 国家级, 2013-01--2016-12
（ 4 ） 转录因子RFX2调控小鼠精子细胞发育基因转录及表观遗传状态的机理, 主持, 国家级, 2015-01--2018-12

已指导学生

粘红  博士研究生  071003-生理学  

张可莹  博士研究生  071003-生理学  

张珠强  博士研究生  071003-生理学  

姚少远  硕士研究生  071003-生理学  

张妍  博士研究生  071003-生理学  

杨用光  博士研究生  071008-发育生物学  

廖尚英  博士研究生  071003-生理学  

甘海云  博士研究生  071008-发育生物学  

张伟  博士研究生  071008-发育生物学  

王丽贤  硕士研究生  071008-发育生物学  

侯小君  博士研究生  071008-发育生物学  

冯雪  博士研究生  071008-发育生物学  

王国军  硕士研究生  071008-发育生物学  

肖振宇  硕士研究生  071008-发育生物学  

吴玉剑  博士研究生  071008-发育生物学  

马婷婷  硕士研究生  071008-发育生物学  

王思  博士研究生  071008-发育生物学  

李振  硕士研究生  071008-发育生物学  

现指导学生

陈建  博士研究生  071008-发育生物学  

胡香静  博士研究生  071008-发育生物学  

冯艳敏  博士研究生  071008-发育生物学  

张道琴  博士研究生  071008-发育生物学  

马龙飞  硕士研究生  071008-发育生物学  

郑春伟  博士研究生  071008-发育生物学  

宁岩  硕士研究生  071008-发育生物学  

谢丹  硕士研究生  071008-发育生物学  

王杨  博士研究生  071008-发育生物学