发表论文
[1] Bo Tang, Li Tang, Wei He, Xingyu Jiang, Changjiang Hu, Yicheng Li, Yang Zhang, Kun Pang, Yuanyuan Lei, Shengpeng Li, Shuang Liu, Sumin Wang, Min Yang, Zhongjun Li, Fangqing Zhao, Shiming Yang. Correlation of gut microbiota and metabolic functions with the antibody response to the BBIBP-CorV vaccine. Cell Reports Medicine[J]. 2022, 3(10): http://dx.doi.org/10.1016/j.xcrm.2022.100752.[2] Zhao, Yuanyuan, Zhang, Bing, Ma, Yiming, Zhao, Fuqiang, Chen, Jianan, Wang, Bingzhi, Jin, Hua, Zhou, Fulai, Guan, Jiawei, Zhao, Qian, Wang, Hongying, Liu, Qian, Zhao, Fangqing, Wang, Xia. Colorectal Cancer Patient-Derived 2D and 3D Models Efficiently Recapitulate Inter- and Intratumoral Heterogeneity. ADVANCED SCIENCE[J]. 2022, 9(22): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000804684600001.[3] Wu, Wanying, Zhang, Jinyang, Cao, Xiaofei, Cai, Zhengyi, Zhao, Fangqing. Exploring the cellular landscape of circular RNAs using full-length single-cell RNA sequencing. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000810123400005.[4] Zhang, Bing, Hou, Lina, Qi, Hongli, Hou, Lingling, Zhang, Tiancheng, Zhao, Fangqing, Miao, Miao. An Extremely Streamlined Macronuclear Genome in the Free-Living Protozoan Fabrea salina. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2022, 39(4): http://dx.doi.org/10.1093/molbev/msac062.[5] Li, Zhanzhan, Zhang, Bing, Wang, Ning, Zuo, Zhenqiang, Wei, Hong, Zhao, Fangqing. A novel peptide protects against diet-induced obesity by suppressing appetite and modulating the gut microbiota. GUT. 2022, [6] Chen, Shuai, Cao, Xiaofei, Zhang, Jinyang, Wu, Wanying, Zhang, Bing, Zhao, Fangqing. circVAMP3 Drives CAPRIN1 Phase Separation and Inhibits Hepatocellular Carcinoma by Suppressing c-Myc Translation. ADVANCED SCIENCE[J]. 2022, 9(8): http://dx.doi.org/10.1002/advs.202103817.[7] Xiao, Liwen, Zhang, Fengyi, Zhao, Fangqing. Large-scale microbiome data integration enables robust biomarker identification. Nature Computational Science[J]. 2022, [8] Xiaobing Wang, Kun Pang, Jinfeng Wang, Bing Zhang, Zhenwei Liu, Saisai Lu, Xin Xu, Lingxiao Zhu, Zihao Zhou, Miaomiao Niu, Jianxia Gao, Jianmin Li, Fangqing Zhao, Jinyu Wu. Microbiota dysbiosis in primary Sjögren’s syndrome and the ameliorative effect of hydroxychloroquine. Cell Reports[J]. 2022, 40(11): http://dx.doi.org/10.1016/j.celrep.2022.111352.[9] Yang, Jing, Hou, Lingling, Wang, Jinfeng, Xiao, Liwen, Zhang, Jinyang, Yin, Nanlin, Yao, Su, Cheng, Kun, Zhang, Wen, Shi, Zhonghua, Wang, Jing, Jiang, Hai, Huang, Nana, You, Yanxia, Lin, Mingmei, Shang, Ruiyan, Wei, Yuan, Zhao, Yangyu, Zhao, Fangqing. Unfavourable intrauterine environment contributes to abnormal gut microbiome and metabolome in twins. GUT. 2022, http://dx.doi.org/10.1136/gutjnl-2021-326482.[10] He, Ruiqiao, Li, Pan, Wang, Jinfeng, Cui, Bota, Zhang, Faming, Zhao, Fangqing. The interplay of gut microbiota between donors and recipients determines the efficacy of fecal microbiota transplantation. GUT MICROBES[J]. 2022, 14(1): [11] Yu, You, Zhang, Bing, Ji, Peifeng, Zuo, Zhenqiang, Huang, Yongxi, Wang, Ning, Liu, Chang, Liu, ShuangJiang, Zhao, Fangqing. Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8(+/-) mouse model of ASD-like behavior. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-28746-2.[12] Chen, Shuai, Zhang,Jinyang, Zhao, Fangqing. Screening Linear and Circular RNA Transcripts from Stress Granules. Genomics, Proteomics & Bioinformatics[J]. 2022, [13] Xiaoai Zhang, Qingzhi Zhai, Jinfeng Wang, Xiuling Ma, Bo Xing, Hang Fan, Zhiying Gao, Fangqing Zhao, Wei Liu. Variation of the Vaginal Microbiome During and after Pregnancy in Chinese Women. Genomics, Proteomics & Bioinformatics[J]. 2022, http://dx.doi.org/10.1016/j.gpb.2021.08.013.[14] You Yu, Fangqing Zhao. Microbiota-gut-brain axis in autism spectrum disorder. 遗传学报:英文版[J]. 2021, 48(9): 755-762, http://lib.cqvip.com/Qikan/Article/Detail?id=7106039601.[15] Zhang, Jinyang, Zhao, Fangqing. Characterizing Circular RNAs Using Nanopore Sequencing. TRENDS IN BIOCHEMICAL SCIENCES. 2021, 46(9): 785-786, http://dx.doi.org/10.1016/j.tibs.2021.06.002.[16] Zhang, Jinyang, Hou, Lingling, Zuo, Zhenqiang, Ji, Peifeng, Zhang, Xiaorong, Xue, Yuanchao, Zhao, Fangqing. Comprehensive profiling of circular RNAs with nanopore sequencing and CIRI-long. NATURE BIOTECHNOLOGY[J]. 2021, 39(7): 836-845, http://dx.doi.org/10.1038/s41587-021-00842-6.[17] Jinfeng Wang, Zhanzhan Li, Xiuling Ma, Lifeng Du, Zhen Jia, Xue Cui, Liqun Yu, Jing Yang, Liwen Xiao, Bing Zhang, Huimin Fan, Fangqing Zhao. Translocation of vaginal microbiota is involved in impairment and protection of uterine health. NATURE COMMUNICATIONS[J]. 2021, 12(1): http://dx.doi.org/10.1038/s41467-021-24516-8.[18] Zhang, Jinyang, Zhao, Fangqing. Reconstruction of circular RNAs using Illumina and Nanopore RNA-seq datasets. METHODS[J]. 2021, 196: 17-22, http://dx.doi.org/10.1016/j.ymeth.2021.03.017.[19] Yao Meng, Liwen Xiao, Wenbing Chen, Fangqing Zhao, Xiang Zhao. An efficient metatranscriptomic approach for capturing RNA virome and its application to SARS-CoV-2. 遗传学报:英文版[J]. 2021, 48(9): 860-862, http://lib.cqvip.com/Qikan/Article/Detail?id=7106039612.[20] Xiao, Liwen, Wang, Jinfeng, Zheng, Jiayong, Li, Xiaoqing, Zhao, Fangqing. Deterministic transition of enterotypes shapes the infant gut microbiome at an early age. GENOME BIOLOGY[J]. 2021, 22(1): http://dx.doi.org/10.1186/s13059-021-02463-3.[21] Zheng, Yi, Zhao, Fangqing. Visualization of circular RNAs and their internal splicing events from transcriptomic data. BIOINFORMATICS[J]. 2020, 36(9): 2934-2935, https://www.webofscience.com/wos/woscc/full-record/WOS:000537450900046.[22] 赵方庆. CircAltas: an integrated resource of one million highly confident circular RNAs from 1070 vertebrate transcriptomes.. Genome Biology. 2020, [23] Wu, Wanying, Ji, Peifeng, Zhao, Fangqing. CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes. GENOME BIOLOGY[J]. 2020, 21(1): http://dx.doi.org/10.1186/s13059-020-02018-y.[24] Jia, Na, Wang, Jinfeng, Shi, Wenqiang, Du, Lifeng, Sun, Yi, Zhan, Wei, Jiang, JiaFu, Wang, Qian, Zhang, Bing, Ji, Peifeng, BellSakyi, Lesley, Cui, XiaoMing, Yuan, TingTing, Jiang, BaoGui, Yang, WeiFei, Lam, Tommy TsanYuk, Chang, QiaoCheng, Ding, ShuJun, Wang, XianJun, Zhu, JinGuo, Ruan, XiangDong, Zhao, Lin, Wei, JiaTe, Ye, RunZe, Que, Teng Cheng, Du, ChunHong, Zhou, YuHao, Cheng, Jing Xia, Dai, PeiFang, Guo, WenBin, Han, XiaoHu, Huang, EnJiong, Li, LianFeng, Wei, Wei, Gao, YuChi, Liu, JingZe, Shao, HongZe, Wang, Xin, Wang, ChongCai, Yang, TianCi, Huo, QiuBo, Li, Wei, Chen, HaiYing, Chen, ShenEn, Zhou, LingGuo, Ni, XueBing, Tian, JunHua, Sheng, Yue, Liu, Tao, Pan, YuSheng, Xia, LuoYuan, Li, Jie, Zhao, Fangqing, Cao, WuChun, Tick Genome Microbiome Consortium. Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities. CELL[J]. 2020, 182(5): 1328-+, http://dx.doi.org/10.1016/j.cell.2020.07.023.[25] Jinyang Zhang, Shuai Chen, Jingwen Yang, Fangqing Zhao. Accurate quantification of circular RNAs identifies extensive circular isoform switching events. Nature Communications[J]. 2020, 11(1): 1-14, http://dx.doi.org/10.1038/s41467-019-13840-9.[26] Wang, Jinfeng, Jia, Zhen, Zhang, Bing, Peng, Lei, Zhao, Fangqing. Tracing the accumulation of in vivo human oral microbiota elucidates microbial community dynamics at the gateway to the GI tract. GUTnull. 2020, 69(7): 1355-1356, https://www.webofscience.com/wos/woscc/full-record/WOS:000569655200025.[27] Zheng, Yi, Ji, Peifeng, Chen, Shuai, Hou, Lingling, Zhao, Fangqing. Reconstruction of full-length circular RNAs enables isoform-level quantification. GENOME MEDICINE[J]. 2019, 11(1): https://doaj.org/article/19379e7aaebd4476b9d9ba07aa48ca28.[28] Ji, Peifeng, Wu, Wanying, Chen, Shuai, Zheng, Yi, Zhou, Lin, Zhang, Jinyang, Cheng, Hao, Yan, Jin, Zhang, Shaogeng, Yang, Penghui, Zhao, Fangqing. Expanded Expression Landscape and Prioritization of Circular RNAs in Mammals. CELL REPORTS[J]. 2019, 26(12): 3444-+, http://dx.doi.org/10.1016/j.celrep.2019.02.078.[29] 赵方庆. Tracing the accumulation of in vivo human oral microbiota elucidates microbial community dynamics at the gateway to the gastrointestinal tract. Gut. 2019, [30] He, Ming, Wang, Jinfeng, Fan, Xinpeng, Liu, Xiaohui, Shi, Wenyu, Huang, Ning, Zhao, Fangqing, Miao, Miao. Genetic basis for the establishment of endosymbiosis in Paramecium. ISME JOURNAL[J]. 2019, 13(5): 1360-1369, [31] Cao, Yuanwei, Sun, Wen, Wang, Jinfeng, Sheng, Gang, Xiang, Guanghai, Zhang, Tongtong, Shi, Wenyu, Li, Chun, Wang, Yanli, Zhao, Fangqing, Wang, Haoyi. Argonaute proteins from human gastrointestinal bacteria catalyze DNA-guided cleavage of single- and double-stranded DNA at 37 degrees C. CELL DISCOVERYnull. 2019, 5: https://www.webofscience.com/wos/woscc/full-record/WOS:000478100600001.[32] Xu, Yuan, Zhao, Fangqing. Single-cell metagenomics: challenges and applications. PROTEIN & CELL[J]. 2018, 9(5): 501-510, http://lib.cqvip.com/Qikan/Article/Detail?id=675367376.[33] Yuan Xu, Fangqing Zhao. Single-cell metagenomics: challenges and applications. 蛋白质与细胞:英文版[J]. 2018, 9(5): 501-510, http://lib.cqvip.com/Qikan/Article/Detail?id=675367376.[34] Gao, Yuan, Zhao, Fangqing. Computational Strategies for Exploring Circular RNAs. TRENDS IN GENETICSnull. 2018, 34(5): 389-400, http://dx.doi.org/10.1016/j.tig.2017.12.016.[35] Gao, Yuan, Zhang, Jinyang, Zhao, Fangqing. Circular RNA identification based on multiple seed matching. BRIEFINGS IN BIOINFORMATICS[J]. 2018, 19(5): 803-810, https://www.webofscience.com/wos/woscc/full-record/WOS:000453743200008.[36] Zhou, Lin, Zhao, Fangqing. Prioritization and functional assessment of noncoding variants associated with complex diseases. GENOME MEDICINE[J]. 2018, 10(1): https://doaj.org/article/888ef501469e48e89b0ba8eef3bb8774.[37] Fangqing Zhao. Mining the hidden treasures from canid genomes. National Science Review. 2018, 6(1): 124-124, [38] Wang, Jinfeng, Zheng, Jiayong, Shi, Wenyu, Du, Nan, Xu, Xiaomin, Zhang, Yanming, Ji, Peifeng, Zhang, Fengyi, Jia, Zhen, Wang, Yeping, Zheng, Zhi, Zhang, Hongping, Zhao, Fangqing. Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus. GUT[J]. 2018, 67(9): 1614-1625, [39] Peifeng Ji, Yanming Zhang, Jinfeng Wang, Fangqing Zhao. MetaSort untangles metagenome assembly by reducing microbial community complexity. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/848e7faf7be0413696f7c8d9de4c4b4c.[40] Teng, Huajing, Zhang, Yaohua, Shi, Chengmin, Mao, Fengbiao, Cai, Wanshi, Lu, Liang, Zhao, Fangqing, Sun, Zhongsheng, Zhang, Jianxu. Population Genomics Reveals Speciation and Introgression between Brown Norway Rats and Their Sibling Species. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2017, 34(9): 2214-2228, https://www.webofscience.com/wos/woscc/full-record/WOS:000408307400008.[41] 赵方庆. The combination of direct and paired link graphs boosts repetitive genome assembly. Nucleic Acids Research. 2017, [42] Zhang, Yanming, Ji, Peifeng, Wang, Jinfeng, Zhao, Fangqing. RiboFR-Seq: a novel approach to linking 16S rRNA amplicon profiles to metagenomes. NUCLEIC ACIDS RESEARCH[J]. 2016, 44(10): e99-e99, https://www.webofscience.com/wos/woscc/full-record/WOS:000379754600009.[43] Nie, Yong, Zhao, JieYu, Tang, YueQin, Guo, Peng, Yang, Yunfeng, Wu, XiaoLei, Zhao, Fangqing. Species Divergence vs. Functional Convergence Characterizes Crude Oil Microbial Community Assembly. FRONTIERS IN MICROBIOLOGY[J]. 2016, 7: https://doaj.org/article/178f9aa151334ca7ade735cb58a14269.[44] Peng, Gongxin, Ji, Peifeng, Zhao, Fangqing. A novel codon-based de Bruijn graph algorithm for gene construction from unassembled transcriptomes. GENOME BIOLOGY[J]. 2016, 17: http://dx.doi.org/10.1186/s13059-016-1094-x.[45] Zhang, Zhigang, Xu, Dongming, Wang, Li, Hao, Junjun, Wang, Jinfeng, Zhou, Xin, Wang, Weiwei, Qiu, Qiang, Huang, Xiaodan, Zhou, Jianwei, Long, Ruijun, Zhao, Fangqing, Shi, Peng. Convergent Evolution of Rumen Microbiomes in High-Altitude Mammals. CURRENT BIOLOGY[J]. 2016, 26(14): 1873-1879, http://dx.doi.org/10.1016/j.cub.2016.05.012.[46] Wang, Jinfeng, Gao, Yuan, Zhao, Fangqing. Phage-bacteria interaction network in human oral microbiome. ENVIRONMENTAL MICROBIOLOGY[J]. 2016, 18(7): 2143-2158, http://dx.doi.org/10.1111/1462-2920.12923.[47] Yuan Gao, Jinfeng Wang, Yi Zheng, Jinyang Zhang, Shuai Chen, Fangqing Zhao. Comprehensive identification of internal structure and alternative splicing events in circular RNAs. NATURE COMMUNICATIONS[J]. 2016, 7(1): https://doaj.org/article/93096215f89a432a93d7cb77e31c1101.[48] Gao, Yuan, Wang, Jinfeng, Zhao, Fangqing. CIRI: an efficient and unbiased algorithm for de novo circular RNA identification. GENOME BIOLOGY[J]. 2015, 16(1): http://www.corc.org.cn/handle/1471x/2374326.[49] Chen, Xiao, Zhao, Xiaolu, Liu, Xiaohui, Warren, Alan, Zhao, Fangqing, Miao, Miao. Phylogenomics of non-model ciliates based on transcriptomic analyses. PROTEIN & CELL[J]. 2015, 6(5): 373-385, http://lib.cqvip.com/Qikan/Article/Detail?id=664784215.[50] Zhao, Hui, Zhao, Fangqing. BreakSeek: a breakpoint-based algorithm for full spectral range INDEL detection. NUCLEIC ACIDS RESEARCH[J]. 2015, 43(14): 6701-6713, https://www.webofscience.com/wos/woscc/full-record/WOS:000360588200012.[51] Ye, Naihao, Zhang, Xiaowen, Miao, Miao, Fan, Xiao, Zheng, Yi, Xu, Dong, Wang, Jinfeng, Zhou, Lin, Wang, Dongsheng, Gao, Yuan, Wang, Yitao, Shi, Wenyu, Ji, Peifeng, Li, Demao, Guan, Zheng, Shao, Changwei, Zhuang, Zhimeng, Gao, Zhengquan, Qi, Ji, Zhao, Fangqing. Saccharina genomes provide novel insight into kelp biology. NATURE COMMUNICATIONS[J]. 2015, 6: http://dx.doi.org/10.1038/ncomms7986.[52] Liu, Jiemeng, Wang, Haifeng, Yang, Hongxing, Zhang, Yizhe, Wang, Jinfeng, Zhao, Fangqing, Qi, Ji. Composition-based classification of short metagenomic sequences elucidates the landscapes of taxonomic and functional enrichment of microorganisms. NUCLEIC ACIDS RESEARCH[J]. 2013, 41(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000312889900003.[53] Guan, Xiangyu, Wang, Jinfeng, Zhao, Hui, Wang, Jianjun, Luo, Ximing, Liu, Fei, Zhao, Fangqing. Soil bacterial communities shaped by geochemical factors and land use in a less-explored area, Tibetan Plateau. BMC GENOMICS[J]. 2013, 14: http://dx.doi.org/10.1186/1471-2164-14-820.[54] Wang, Jinfeng, Qi, Ji, Zhao, Hui, He, Shu, Zhang, Yifei, Wei, Shicheng, Zhao, Fangqing. Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease. SCIENTIFIC REPORTS[J]. 2013, 3: https://www.webofscience.com/wos/woscc/full-record/WOS:000318893700001.[55] Shen, Xin, Tian, Mei, Meng, Xueping, Liu, Huilian, Cheng, Hanliang, Zhu, Changbao, Zhao, Fangqing. Complete mitochondrial genome of Membranipora grandicella (Bryozoa: Cheilostomatida) determined with next-generation sequencing: The first representative of the suborder Malacostegina. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS[J]. 2012, 7(3): 248-253, http://dx.doi.org/10.1016/j.cbd.2012.03.003.[56] Zhou, Linglin, Li, Xueying, Liu, Qi, Zhao, Fangqing, Wu, Jinyu. Small RNA transcriptome investigation based on next-generation sequencing technology. JOURNAL OF GENETICS AND GENOMICS[J]. 2011, 38(11): 505-513, http://lib.cqvip.com/Qikan/Article/Detail?id=40193140.[57] 赵方庆. A new scheme to identify and visualize structural variations from paired-end mapping data. Nucleic Acids Res. 2011, [58] Zhu, Erle, Zhao, Fangqing, Xu, Gang, Hou, Huabin, Zhou, LingLin, Li, Xiaokun, Wu, Jinyu, 孙中生, Xiaokun Li, Jinyu Wu. mirTools: microRNA profiling and discovery based on high-throughput sequencing. NUCLEIC ACIDS RESEARCH[J]. 2010, 38(1): W392-W397, http://dx.doi.org/10.1093/nar/gkq393.[59] Hou HB, Zhao FQ, Zhou LL, Zhu EL, Teng HJ, Li XK, Bao QY, Wu JY, 孙中生, Jinyu Wu. MagicViewer: integrated solution for next-generation sequencing data visualization and genetic variation detection and annotation. NUCLEIC ACIDS RESEARCH[J]. 2010, 38(5): W732-W736, http://dx.doi.org/10.1093/nar/gkq302.[60] Zhao, Fangqing, Hou, Huabin, Bao, Qiyu, Wu, Jinyu. PGA4genomics for comparative genome assembly based on genetic algorithm optimization. GENOMICS[J]. 2009, 94(4): 284-286, http://dx.doi.org/10.1016/j.ygeno.2009.06.006.[61] Zhao, Fangqing, Qi, Ji, Schuster, Stephan C. Tracking the past: Interspersed repeats in an extinct Afrotherian mammal, Mammuthus primigenius. GENOME RESEARCH[J]. 2009, 19(8): 1384-1392, https://www.webofscience.com/wos/woscc/full-record/WOS:000268597600006.[62] Chi, Xiaoyuan, Yang, Qingli, Zhao, Fangqing, Qin, Song, Yang, Yu, Shen, Junjun, Lin, Hanzhi. Comparative Analysis of Fatty Acid Desaturases in Cyanobacterial Genomes. COMPARATIVE AND FUNCTIONAL GENOMICS[J]. 2008, http://ir.qdio.ac.cn/handle/337002/1586.[63] 赵方庆. A novel pheromone trail-based genetic algorithm for comparative genome assembly. Nucleic Acids Res. 2008, [64] Liang ChengWei, Zhao FangQing, Qin Song, Tan CongPing, Wei Wei, Meng ChunXiao. Molecular cloning and characterization of phytoene synthase gene from a unicellular green alga Haematococcus pluvialis. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2006, 33(9): 854-860, http://www.corc.org.cn/handle/1471x/2378913.[65] Liang ChengWei, Zhao FangQing, Qin Song, Tan CongPing, Wei Wei, Meng ChunXiao. Molecular cloning and characterization of phytoene synthase gene from a unicellular green alga Haematococcus pluvialis. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2006, 33(9): 854-860, http://www.corc.org.cn/handle/1471x/2378913.[66] Bo Tang, Li Tang, Wei He, Xingyu Jiang, Changjiang Hu, Yicheng Li, Yang Zhang, Kun Pang, Yuanyuan Lei, Shengpeng Li, Shuang Liu, Sumin Wang, Min Yang, Zhongjun Li, Fangqing Zhao, Shiming Yang. Correlation of gut microbiota and metabolic functions with the antibody response to the BBIBP-CorV vaccine. Cell Reports Medicine. http://dx.doi.org/10.1016/j.xcrm.2022.100752.