基本信息
陈纪军  男  博导  中国科学院昆明植物研究所
办公电话: 0871-65223265
电子邮件: chenjj@mail.kib.ac.cn
通信地址: 云南省昆明市蓝黑路132号(黑龙潭)

邮政编码: 650201

招生信息

   
招生专业
100701-药物化学
100800-中药学
070303-有机化学
招生方向
抗病毒与天然药物研发
天然药物化学
中药药效物质

教育背景

1996-10--1998-07   日本京都大学化学研究所   博士后
1992-09--1995-06   中国科学院昆明植物研究所   理学博士
1986-09--1989-07   中国科学院昆明植物研究所   理学硕士
1982-09--1986-07   西安医科大学   理学学士
学历
昆明植物研究所 19920901--19950731 研究生
学位
昆明植物研究所 19920901--19950731 理学博士学位

工作经历

   
工作简历
2003-03~现在, 中国科学院昆明植物研究所, 研究员
1998-07~2003-03,中国科学院昆明植物研究所, 副研究员
1992-03~1996-10,中国科学院昆明植物研究所, 助理研究员
1989-08~1992-03,中国科学院昆明植物研究所, 研究实习员
社会兼职
2013-06-13-今,农工党第十五届中央生物技术与药学工作委员会, 副主任
2012-07-18-今,农工民主党云南省第六届委员会, 常务委员

教授课程

天然药物化学

专利与奖励

   
奖励信息
(1) 天然抗乙型病毒性肝炎活性化合物发现与结构优化, 二等奖, 省级, 2018
(2) 百千万人才工程入选者并获国家有突出贡献中青年专家, , 国家级, 2014
(3) 中国科学院朱李月华优秀教师, , 院级, 2012
(4) 中国科学院王宽诚西部学者突出贡献奖, , 院级, 2010
(5) 国务院政府特殊津贴, , 国家级, 2010
专利成果
[1] 陈纪军, 李天泽, 杨晓烔, 马云保, 黄晓燕, 耿长安, 张雪梅, 胡敬. 多花蒿内酯H衍生物及其药物组合物和其制备方法与应用. CN116082284A, 2023-05-09.
[2] 陈纪军, 商冲, 李天泽, 耿长安, 张雪梅, 黄晓燕. 蒙古蒿内酯A-F及其药物组合物和其制备方法与应用. CN115894418A, 2023-04-04.
[3] 马云保, 陈纪军, 王远, 李天泽, 耿长安, 张雪梅, 黄晓燕, 胡敬. 白叶蒿内酯A-L及其药物组合物和其制备方法与应用. CN115785041A, 2023-03-14.
[4] 陈纪军, 高振, 李天泽, 马云保, 耿长安, 黄晓燕, 胡敬, 张雪梅. 牛尾蒿倍半萜内酯A-N及其药物组合物和其制备方法与应用. CN115745933A, 2023-03-07.
[5] 陈纪军, 何小凤, 李天泽, 耿长安, 马云保, 张雪梅, 黄晓燕, 胡敬. 南牡蒿内酯A-D及其药物组合物和其应用. CN115490660A, 2022-12-20.
[6] 陈纪军, 董伟, 耿长安, 黄晓燕, 马云保, 李天泽, 张雪梅. 中甸艾中倍半萜二聚体及其药物组合物与其制备方法和应用. CN115010720A, 2022-09-06.
[7] 陈纪军, 李天泽, 马云保, 耿长安, 黄晓燕, 胡敬, 张雪梅. 一种愈创木烷倍半萜二聚体及其衍生物和其在制药中的应用. CN115010719A, 2022-09-06.
[8] 陈纪军, 何小凤, 李天泽, 耿长安, 马云保, 张雪梅, 黄晓燕, 胡敬. 南牡蒿素及其药物组合物和其制备方法与应用. CN114957190A, 2022-08-20.
[9] 马云保, 张鑫, 陈纪军, 李天泽, 耿长安. 多花蒿内酯A-J及其药物组合物与其制备方法和应用. CN114874170A, 2022-08-09.
[10] 陈纪军, 李天泽, 孙金金, 王金平, 马云保, 黄晓燕, 耿长安, 胡敬, 张雪梅. Ludartin衍生物和其药物组合物及其制备方法和应用. CN114539195A, 2022-05-27.
[11] 陈纪军, 高振, 李天泽, 马云保, 马文静, 耿长安, 何小凤, 黄晓燕, 胡敬, 张雪梅. 牛尾蒿内酯A-T及其药物组合物和其制备方法与应用. CN114524825A, 2022-05-24.
[12] 耿长安, 陈纪军, 丁敏, 李天泽, 张雪梅, 黄晓燕, 马云保, 胡敬. 砂仁素A~D及其药物组合物与其制备方法和应用. CN114560842A, 2022-05-11.
[13] 耿长安, 陈纪军, 何小凤, 李天泽, 张雪梅, 黄晓燕, 马云保, 胡敬. 二芳基庚烷二聚体及其药物组合物与其制备方法和应用. CN: CN113929698A, 2022-01-14.
[14] 陈纪军, 李天泽, 马云保, 耿长安, 张雪梅. 愈创木烷倍半萜多聚体与其药物及其制备方法和应用. CN: CN113788840A, 2021-12-14.
[15] 陈纪军, 杨晓烔, 李天泽, 耿长安. 20S,24R-环氧-达玛烷-3β,12β,25-三醇衍生物与其药物组合物. CN: CN113730419A, 2021-12-03.
[16] 陈纪军, 李天泽, 耿长安, 张雪梅. 愈创木烷倍半萜二聚体的制备方法. CN: CN113735875A, 2021-12-03.
[17] 耿长安, 陈纪军, 何小凤, 胡敬, 李天泽, 张雪梅, 黄晓燕, 马云保. 一类新颖二芳基庚烷-黄烷酮杂合体及其药物组合物和应用. CN: CN113582981A, 2021-11-02.
[18] 陈纪军, 苏丽花, 李天泽, 耿长安, 马云保, 黄晓燕, 胡敬, 张雪梅. 暗绿蒿烯内酯A-L及其药物组合物和其应用. CN: CN113527324A, 2021-10-22.
[19] 陈纪军, 苏丽花, 马云保, 耿长安, 李天泽, 黄晓燕, 胡敬, 张雪梅. 暗绿蒿素A-P及其药物组合物与其制备方法和应用. CN: CN113185562A, 2021-07-30.
[20] 陈纪军, 高振, 黄晓燕, 耿长安, 李天泽, 马云保, 胡敬, 张雪梅. 茵陈蒿中香豆酸及其药物组合物与其制备方法和应用. CN: CN113173905A, 2021-07-27.
[21] 耿长安, 何小凤, 陈纪军, 张雪梅, 黄晓燕, 马云保, 李天泽, 胡敬. 一种2,6-环氧二苯基庚烷类化合物及其制备方法和应用、药物组合物及其应用. CN: CN110903270B, 2021-07-09.
[22] 陈纪军, 王金平, 李天泽, 黄晓燕, 耿长安, 马云保, 张雪梅, 胡敬. 珊塔玛内酯衍生物及其药物组合物和其制备方法与应用. CN: CN112939910A, 2021-06-11.
[23] 耿长安, 何小凤, 陈纪军, 张雪梅, 胡敬, 李天泽, 黄晓燕, 马云保. 草豆蔻中二芳基庚烷-查尔酮聚合物及其药物组合物与应用. CN: CN112592328A, 2021-04-02.
[24] 陈纪军, 苏丽花, 耿长安, 张心湉, 马云保, 黄晓燕, 李天泽, 胡敬, 张雪梅. 暗绿蒿内酯A-R及其药物组合物和应用. CN: CN112225746A, 2021-01-15.
[25] 耿长安, 何小凤, 陈纪军, 张雪梅, 黄晓燕, 马云保, 李天泽, 胡敬. 一种二苯基庚烷类化合物及其制备方法和应用、药物组合物及其应用. CN: CN110964027B, 2020-12-18.
[26] 陈纪军, 苏丽花, 耿长安, 马云保, 黄晓燕, 张心湉, 李天泽, 张雪梅. 暗绿蒿醇A-B及其药物组合物和其制备方法与应用. CN: CN112062738A, 2020-12-11.
[27] 耿长安, 何小凤, 陈纪军, 胡敬, 李天泽, 黄晓燕, 马云保, 张雪梅. 黄烷醇-脂肪醇杂合体及其药物组合物与其制备方法和应用. CN: CN111978330A, 2020-11-24.
[28] 陈纪军, 唐爽, 耿长安, 张心湉, 马云保, 黄晓燕, 李天泽, 张雪梅. 多花蒿烯内酯A-S和多花蒿素A-G及其药物组合物和应用. CN: CN111704594A, 2020-09-25.
[29] 耿长安, 何小凤, 陈纪军, 胡敬, 李天泽, 黄晓燕, 马云保, 张雪梅. 黄烷醇-薄荷烷杂合体及其药物组合物与其制备方法和应用. CN: CN111704622A, 2020-09-25.
[30] 陈纪军, 申程, 耿长安, 黄晓燕, 马云保, 李天泽, 张雪梅. 野艾蒿中倍半萜及其药物组合物与其制备方法和应用. CN: CN111635380A, 2020-09-08.
[31] 陈纪军, 李天泽, 张雪梅, 耿长安. 苔黑酚葡萄糖苷的制备方法. CN: CN111233951A, 2020-06-05.
[32] 耿长安, 陈纪军, 杨晓烔, 李天泽, 黄晓燕, 胡敬. 先花铃子香素A衍生物与其药物组合物及其制备方法和应用. CN: CN111233702A, 2020-06-05.
[33] 耿长安, 高振, 陈纪军, 张雪梅, 马云保, 黄晓燕, 李天泽, 胡敬. 香豆酸类化合物的应用、药物组合物及其应用. CN: CN110917184A, 2020-03-27.
[34] 陈纪军, 耿长安, 陈思月, 黄晓燕, 马云保, 李天泽, 杨通华, 张雪梅. 双酚F在制备治疗中枢神经系统疾病的药物中的应用. CN: CN109820840A, 2019-05-31.
[35] 陈纪军, 陈思月, 耿长安, 马云保, 黄晓燕, 张雪梅. 多聚苄衍生物及其药物组合物与其制备方法和其应用. CN: CN109809971A, 2019-05-28.
[36] 耿长安, 陈纪军, 张晨晨, 黄晓燕, 马云保, 张雪梅. Paeonilactiflorol及其药物组合物与其制备方法和应用. CN: CN109810084A, 2019-05-28.
[37] 耿长安, 陈纪军, 张晨晨, 黄晓燕, 马云保, 张雪梅. 芍药籽中寡聚芪类化合物在制药中的应用. CN: CN109700796A, 2019-05-03.
[38] 耿长安, 陈纪军, 张晨晨, 黄晓燕, 张雪梅, 马云保. 芍药籽提取物在制药中的应用. CN: CN109692209A, 2019-04-30.
[39] 耿长安, 陈纪军, 闫孟红, 马云保, 黄晓燕, 张雪梅. 构树中黄酮类成分在制备抗口腔菌疾病的药物中的应用. CN: CN109172640A, 2019-01-11.
[40] 耿长安, 陈纪军, 闫孟红, 马云保, 黄晓燕, 张雪梅. 构树醇化合物及其组合物与其用途. CN: CN109180660A, 2019-01-11.
[41] 耿长安, 陈纪军, 闫孟红, 马云保, 黄晓燕, 张雪梅. 构树提取物在制备抗口腔疾病的产品中的应用. CN: CN108904594A, 2018-11-30.
[42] 陈纪军, 耿长安, 马云保, 黄晓燕, 张雪梅, 杨静. 8S-癸-9-烯-4,6-二炔-1,8-二醇及其药物组合物和应用. CN: CN108821947A, 2018-11-16.
[43] 陈纪军, 耿长安, 黄晓燕, 马云保, 张雪梅. 茵陈三炔醇类化合物及其药物组合物和其用途. CN: CN108569953A, 2018-09-25.
[44] 陈纪军, 耿长安, 黄晓燕, 马云保, 张雪梅. 茵陈三炔酸类化合物及其药物组合物和其用途. CN: CN108530292A, 2018-09-14.
[45] 陈纪军, 颜得秀, 耿长安, 杨通华, 黄晓燕, 李天泽, 高振, 马云保, 张雪梅. 异序乌桕素A-H及其药物组合物和其应用. CN: CN108440292A, 2018-08-24.
[46] 陈纪军, 颜得秀, 耿长安, 杨通华, 黄晓燕, 高振, 李天泽, 马云保, 张雪梅. 异序乌桕素I和J及其药物组合物和其应用. CN: CN108314620A, 2018-07-24.
[47] 陈纪军, 杨通华, 耿长安, 马云保, 颜得秀, 黄晓燕, 张雪梅. 厚朴酚糖苷在制备治疗中枢神经系统疾病药物中的应用. CN: CN108143741A, 2018-06-12.
[48] 陈纪军, 耿长安, 梁文娟, 黄晓燕, 马云保, 李天泽, 杨通华, 张雪梅. Paeonivayin在制备治疗中枢神经系统疾病的药物中的应用. CN: CN107898799A, 2018-04-13.
[49] 耿长安, 陈纪军, 张建钢, 黄晓燕, 马云保, 李天泽, 杨通华, 张雪梅. 钩藤酰胺A及其药物组合物和应用. CN: CN107827940A, 2018-03-23.
[50] 陈纪军, 杨通华, 李天泽, 耿长安, 张雪梅. (20S,24R)‑20,24‑环氧达玛烷‑3β,12β,25‑三醇及其应用. CN: CN107778340A, 2018-03-09.
[51] 陈纪军, 尹秀娟, 马云保, 黄晓燕, 耿长安, 张雪梅. 以芦竹碱衍生物为活性成分的药物组合物及其应用. CN: CN107174586A, 2017-09-19.
[52] 陈纪军, 耿长安, 黄晓燕, 马云保, 李天泽, 张雪梅. (±)UncarilinsA和B及其药物组合物和应用. CN: CN107056790A, 2017-08-18.
[53] 陈纪军, 尹秀娟, 耿长安, 马云保, 黄晓燕, 张雪梅. 芦竹碱衍生物及其药物组合物和其在制药中的应用. CN: CN106905300A, 2017-06-30.
[54] 陈纪军, 尹秀娟, 耿长安, 张雪梅. 托品酮衍生物及其药物组合物和其制备方法与应用. CN: CN105924436A, 2016-09-07.
[55] 陈纪军, 杨通华, 黄晓燕, 马云保, 张雪梅, 沈勇, 耿长安, 卢承杰. Graveobioside A在制备抗高尿酸血症和抗痛风的药物或保健食品中的应用. CN: CN105560262A, 2016-05-11.
[56] 陈纪军, 杨通华, 黄晓燕, 马云保, 张雪梅, 沈勇, 耿长安, 卢承杰. 芹菜籽提取物在制备抗高尿酸血症和抗痛风的药物或保健食品中的应用. CN: CN105535048A, 2016-05-04.
[57] 陈纪军, 耿长安, 马云保, 赵勇, 黄晓燕, 张雪梅. 4-6-乙基-4-(1H)-吡啶酮-2-基-3R-O-β-D-吡喃葡萄糖基丁酸及其药物组合物和应用. CN: CN105111259A, 2015-12-02.
[58] 陈纪军, 耿长安, 黄晓燕, 马云保, 赵勇, 张雪梅. 烯炔糖苷酯类化合物及其药物组合物和应用. CN: CN105111252A, 2015-12-02.
[59] 陈纪军, 孙长利, 耿长安, 黄晓燕, 马云保, 张雪梅. 柴胡总皂苷及其单体皂苷在制药中的应用. CN: CN105055471A, 2015-11-18.
[60] 陈纪军, 赵勇, 马云保, 黄晓燕, 耿长安, 张雪梅. 含桉烷型倍半萜的药物组合物及其在制药中的应用. CN: CN103784427A, 2014-05-14.
[61] 陈纪军, 赵勇, 耿长安, 马云保, 黄晓燕, 张雪梅. 1-O-乙基-6-O-咖啡酰基-β-D-葡萄糖吡喃苷及其药物组合物和应用. CN: CN103788143A, 2014-05-14.
[62] 陈纪军, 陈浩, 耿长安, 马云保, 黄晓燕, 张雪梅. 14-脱氧-14,15-二脱氢穿心莲内酯衍生物及其药物组合物和用途. CN: CN103739597A, 2014-04-23.
[63] 陈纪军, 陈浩, 耿长安, 马云保, 黄晓燕, 张雪梅. 14-脱氧-11,12-二脱氢穿心莲内酯衍生物及其药物组合物和应用. CN: CN103739575A, 2014-04-23.
[64] 陈纪军, 王立军, 张雪梅, 马云保, 罗杰, 黄晓燕. 告达亭衍生物,其药物组合物及其用途. CN: CN102796157A, 2012-11-28.
[65] 陈纪军, 耿长安, 马云保, 张雪梅, 罗杰, 黄晓燕. 獐牙菜内酯H-K,其药物组合物及其用途. CN: CN102532156A, 2012-07-04.
[66] 陈纪军, 郭锐华, 马云保, 江志勇, 黄晓燕, 罗杰, 周俊, 张雪梅. 喹啉衍生物,其药物组合物及其用途. CN: CN102050780A, 2011-05-11.
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出版信息

   
发表论文
[1] YongCui Wang, TianZe Li, JiJun Chen. Compound-protein interaction prediction based on heterogeneous network reveals potential antihepatoma agents. ISCIENCE[J]. 2024, 第 3 作者  通讯作者  27(8): 110418, https://doaj.org/article/38615144ec464bd4b88d0fe124f3e5ed.
[2] Yang, KeXin, Li, TianZe, Ma, YunBao, Wang, YongCui, Li, FengJiao, Chen, JiJun. Three Types of Isocoumarins with Unusual Carbon Skeletons from Artemisia dubia var. subdigitata and Their Antihepatoma Activity. CHINESE JOURNAL OF CHEMISTRY. 2024, 第 6 作者  通讯作者  http://dx.doi.org/10.1002/cjoc.202400172.
[3] XiaoFeng He, YunBao Ma, TianZe Li, JiJun Chen. Highly oxygenated guaiane-type sesquiterpene lactones from Artemisia sacrorum and their antihepatoma activity. PHYTOCHEMISTRY[J]. 2024, 第 4 作者  通讯作者  217(null): http://dx.doi.org/10.1016/j.phytochem.2023.113930.
[4] Wang, Xing, Li, TianZe, Ma, YunBao, Ma, WenJing, Xue, Dong, Chen, JiJun. Synthesis and antihepatoma activity of guaianolide dimers derived from lavandiolide I. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2024, 第 6 作者  通讯作者  104: http://dx.doi.org/10.1016/j.bmcl.2024.129708.
[5] Yang, KeXin, Ma, YunBao, Li, TianZe, Wang, Meng Fei, Li, FengJiao, Chen, JiJun. Artemdubosides A-G, seven unusual polyacetylenes from Artemisia dubia var. subdigitata and their antihepatoma activity. FITOTERAPIA[J]. 2024, 第 6 作者  通讯作者  175: http://dx.doi.org/10.1016/j.fitote.2024.105909.
[6] 董伟, 黄晓燕, 李天泽, 翁俨玫, 耿长安, 陈纪军. Artemsieverolactones A—H, eight guaiane-type sesquiterpenoid trimers from Artemisia sieversiana. Chinese Journal of Chemistry[J]. 2024, 第 6 作者  通讯作者  null(null): 
[7] 何小凤, 李天泽, 马云保, 王梦飞, 陈纪军. Unusual cadinane-involved sesquiterpenoid dimers from Artemisia annua and their antihepatoma effect. Phytochemistry[J]. 2024, 第 5 作者  通讯作者  null(null): 
[8] Wang, Yuan, Li, TianZe, Ma, YunBao, Geng, ChangAn, Wang, YongCui, Chen, JiJun. Artemordins A-S, Cadinane-Type Sesquiterpenoid Dimers from Artemisia ordosica and Their Antihepatoma Activities. CHINESE JOURNAL OF CHEMISTRY. 2024, 第 6 作者  通讯作者  http://dx.doi.org/10.1002/cjoc.202400032.
[9] 王梦飞, 李天泽, 马云保, 马文静, 王永翠, 李启豪, 陈纪军. Artemyriantholides A – K, guaiane-type sesquiterpenoid dimers from Artemisia myriantha var. pleiocephala and their antihepatoma activity. Chinese Journal of Chemistry[J]. 2024, 第 7 作者  通讯作者  null(null): 
[10] He, XiaoFeng, Li, QiHao, Li, TianZe, Ma, YunBao, Dong, Wei, Yang, KeXin, Geng, ChangAn, Zhang, HaoWei, Wang, Yuan, Chen, JiJun. Artemeriopolides A-D, two types of sesquiterpenoid dimers with rare carbon skeletons from Artemisia eriopoda and their antihepatoma cytotoxicity. ORGANIC CHEMISTRY FRONTIERS[J]. 2023, 第 10 作者  通讯作者  10(11): 2635-2641, http://dx.doi.org/10.1039/d3qo00223c.
[11] Su, LiHua, Ma, WenJing, Ma, YunBao, Li, TianZe, Geng, ChangAn, Dong, Wei, He, XiaoFeng, Zhang, XueMei, Chen, JiJun. Artemiprincepsolides A-F, Novel Germacrane-guaiane and Eudesmane-guaiane Sesquiterpenoid Dimers from Artemisia princeps and Their Antihepatoma Activity. CHINESE JOURNAL OF CHEMISTRY[J]. 2023, 第 9 作者  通讯作者  41(20): 2648-2656, http://dx.doi.org/10.1002/cjoc.202300242.
[12] Dong, Wei, Yang, KeXin, He, XiaoFeng, Li, TianZe, Chen, JiJun. New eudesmanolides from Artemisia verlotorum and their potential targets of hepatocellular carcinoma by network pharmacology. FITOTERAPIA[J]. 2023, 第 5 作者  通讯作者  167: http://dx.doi.org/10.1016/j.fitote.2023.105491.
[13] Wang, Yuan, Ma, YunBao, Huang, XiaoYan, Li, TianZe, He, XiaoFeng, Zhang, XueMei, Chen, JiJun. Artemleucolides A-L, eudesmane-type sesquiterpenoids from Artemisia leucophylla and their antihepatoma cytotoxicity. FITOTERAPIA[J]. 2023, 第 7 作者  通讯作者  165: http://dx.doi.org/10.1016/j.fitote.2022.105399.
[14] Yan, JiaXin, Li, QiHao, Li, TianZe, Huang, ZhiYan, Ma, YunBao, Chen, JiJun. Design and synthesis of guaianolide-germacranolide heterodimers as novel anticancer agents against hepatocellular carcinoma. DRUG DEVELOPMENT RESEARCH. 2023, 第 6 作者  通讯作者  http://dx.doi.org/10.1002/ddr.22087.
[15] Shang, Chong, Huang, XiaoYan, Wang, Yuan, Dong, Wei, He, XiaoFeng, Li, TianZe, Chen, JiJun. Artemongolides A-F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2023, 第 7 作者  通讯作者  21(4): 823-831, http://dx.doi.org/10.1039/d2ob02182j.
[16] TianZe Li, XiaoTong Yang, WenJing Ma, YunBao Ma, FengJiao Li, YongCui Wang, JiJun Chen. Design, Synthesis, and Biological Evaluation of Artemyrianolide H Derivatives as Potential Antihepatoma Agents. BIOORGANIC CHEMISTRY[J]. 2023, 第 7 作者  通讯作者  137: 106617, http://dx.doi.org/10.1016/j.bioorg.2023.106617.
[17] Wang, Tian, Wu, ShengLi, Liu, Pei, Chen, JiJun, Zhang, XueMei, Geng, ChangAn. Diarylheptanoids with hypoglycemic potency from the rhizomes of Kaempferia galanga. FITOTERAPIA[J]. 2023, 第 4 作者167: http://dx.doi.org/10.1016/j.fitote.2023.105502.
[18] He, Xiaofeng, Ma, Wenjing, Hu, Jing, Li, Tianze, Geng, Changan, Ma, Yunbao, Wang, Mengfei, Yang, Kexin, Zhang, Xuemei, Chen, JiJun. Diverse structures and antihepatoma effect of sesquiterpenoid dimers from Artemisia eriopoda by AKT/STAT signaling pathway. SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2023, 第 10 作者  通讯作者  8(1): 898-900, http://dx.doi.org/10.1038/s41392-022-01267-6.
[19] Geng, ChangAn, Chen, FengYang, Zheng, JingBin, Liao, Ping, Li, TianZe, Zhang, XueMei, Chen, Xin, Chen, JiJun. Rubiginosin B selectively inhibits Treg cell differentiation and enhances anti-tumor immune responses by targeting calcineurin-NFAT signaling pathway. PHYTOMEDICINE[J]. 2023, 第 8 作者  通讯作者  116: http://dx.doi.org/10.1016/j.phymed.2023.154898.
[20] Dong, Wei, Ma, WenJing, Ma, YunBao, Li, FengJiao, Li, TianZe, Wang, YongCui, He, XiaoFeng, Geng, ChangAn, Zhang, XueMei, Chen, JiJun. Guaiane-type Sesquiterpenoid Dimers from Artemisia zhongdianensis and Antihepatoma Carcinoma Activity via the p38MAPK Pathway. CHINESE JOURNAL OF CHEMISTRY[J]. 2023, 第 10 作者  通讯作者  41(19): 2453-2468, http://dx.doi.org/10.1002/cjoc.202300166.
[21] Su, LiHua, Ma, WenJing, Ma, YunBao, Li, TianZe, Geng, ChangAn, Dong, Wei, He, XiaoFeng, Chen, JiJun. Artemiprinolides A-M, thirteen undescribed sesquiterpenoid dimers from Artemisia princeps and their antihepatoma activity. PHYTOCHEMISTRY[J]. 2023, 第 8 作者  通讯作者  211: http://dx.doi.org/10.1016/j.phytochem.2023.113714.
[22] Shang, Chong, Ma, YunBao, Wang, Yuan, He, XiaoFeng, Li, TianZe, Chen, JiJun. Artemongolins A-K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities. ARCHIVES OF PHARMACAL RESEARCH[J]. 2023, 第 6 作者  通讯作者  46(9-10): 782-794, http://dx.doi.org/10.1007/s12272-023-01466-x.
[23] XiaoFeng He, MengFei Wang, YunBao Ma, TianZe Li, JiJun Chen. Artemeriosides A–F, the first examples of natural sesquiterpenoids substituted by a 6′-O-crontonyl β-glucopyranoside from Artemisia annua. FITOTERAPIA. 2023, 第 5 作者  通讯作者  169: http://dx.doi.org/10.1016/j.fitote.2023.105619.
[24] Sun, JinJin, Wang, JinPing, Li, TianZe, Ma, YunBao, Xue, Dong, Chen, JiJun. Design and synthesis of ludartin derivatives as potential anticancer agents against hepatocellular carcinoma. MEDICINAL CHEMISTRY RESEARCH[J]. 2022, 第 6 作者  通讯作者  31(7): 1224-1239, http://dx.doi.org/10.1007/s00044-022-02890-2.
[25] Su, LiHua, Li, TianZe, Ma, YunBao, Geng, ChangAn, Huang, XiaoYan, Zhang, Xin, Gao, Zhen, Chen, JiJun. Artematrovirenolides A-D and Artematrolides S-Z, Sesquiterpenoid Dimers with Cytotoxicity against Three Hepatoma Cell Lines from Artemisia atrovirens. CHINESEJOURNALOFCHEMISTRY[J]. 2022, 第 8 作者  通讯作者  40(1): 104-114, http://dx.doi.org/10.1002/cjoc.202100528.
[26] Yang, XiaoTong, Li, TianZe, Geng, ChangAn, Liu, Pei, Chen, JiJun. Synthesis and biological evaluation of (20S,24R)-epoxy-dammarane-3 beta,12 beta,25-triol derivatives as alpha-glucosidase and PTP1B inhibitors. MEDICINAL CHEMISTRY RESEARCH[J]. 2022, 第 5 作者  通讯作者  31(2): 350-367, http://dx.doi.org/10.1007/s00044-021-02836-0.
[27] Wu, ShengLi, Zhang, ChenChen, Chen, JiJun, Zhang, XueMei, Guan, Min, Geng, ChangAn. Oligostilbenes from the seeds of Paeonia lactiflora as potent GLP-1 secretagogues targeting TGR5 receptor. FITOTERAPIA[J]. 2022, 第 3 作者163: http://dx.doi.org/10.1016/j.fitote.2022.105336.
[28] Zhen Gao, WenJing Ma, TianZe Li, YunBao Ma, Jing Hu, XiaoYan Huang, ChangAn Geng, XiaoFeng He, XueMei Zhang, JiJun Chen. Artemidubolides A−T, cytotoxic unreported guaiane-type sesquiterpenoid dimers against three hepatoma cell lines from Artemisia dubia. PHYTOCHEMISTRY[J]. 2022, 第 10 作者  通讯作者  202: http://dx.doi.org/10.1016/j.phytochem.2022.113299.
[29] He, XiaoFeng, Wu, ShengLi, Chen, JiJun, Hu, Jing, Huang, XiaoYan, Li, TianZe, Zhang, XueMei, Guo, YuanQiang, Geng, ChangAn. New diarylheptanoid dimers as GLP-1 secretagogues and multiple-enzyme inhibitors from Alpinia katsumadai. BIOORGANIC CHEMISTRY[J]. 2022, 第 3 作者120: http://dx.doi.org/10.1016/j.bioorg.2022.105653.
[30] Li, TianZe, Hu, Jing, Sun, JinJin, Huang, XiaoYan, Geng, ChangAn, Liu, ShuBai, Zhang, XueMei, Chen, JiJun. Synthesis and biological evaluation of paeoveitol D derivatives as new melatonin receptor agonists with antidepressant activities. RSC MEDICINAL CHEMISTRY[J]. 2022, 第 8 作者  通讯作者  13(10): 1212-1224, http://dx.doi.org/10.1039/d2md00156j.
[31] Li, Tian-Ze, Huang,Xiao-Yan, Sun, Jin-Jin, Geng,Chang-An, Zhang,Xue-Mei, Chen,Ji-Jun. Synthesis and biological evaluation of (+)-paeoveitol derivatives as novel antidepressants. Medicinal Chemistry Research[J]. 2022, 第 6 作者  通讯作者  31: 2045-2057, https://doi.org/10.1007/s00044-022-02973-0.
[32] Chen, FengYang, Geng, ChangAn, Chou, ChonKit, Zheng, JingBin, Yang, Yang, Wang, YiFei, Li, TianZe, Li, Ping, Chen, JiJun, Chen, Xin. Distepharinamide, a novel dimeric proaporphine alkaloid from Diploclisia glaucescens, inhibits the differentiation and proliferative expansion of CD4(+)Foxp3(+) regulatory T cells. PHYTOMEDICINE[J]. 2022, 第 9 作者  通讯作者  107: http://dx.doi.org/10.1016/j.phymed.2022.154482.
[33] Dong, Wei, Li, TianZe, Huang, XiaoYan, He, XiaoFeng, Geng, ChangAn, Zhang, XueMei, Chen, JiJun. Artemzhongdianolides A1-A21, antihepatic fibrosis guaiane-type sesquiterpenoid dimers from Artemisia zhongdianensis. BIOORGANIC CHEMISTRY[J]. 2022, 第 7 作者  通讯作者  128: http://dx.doi.org/10.1016/j.bioorg.2022.106056.
[34] Xin Zhang, YunBao Ma, XiaoFeng He, TianZe Li, ChangAn Geng, LiHua Su, Shuang Tang, Zhen Gao, JiJun Chen. Artemyrianosins A–J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha. NATURALPRODUCTSANDBIOPROSPECTING[J]. 2022, 第 9 作者  通讯作者  12(1): 1-12, http://dx.doi.org/10.1007/s13659-022-00340-5.
[35] He, XiaoFeng, Chen, JiJun, Huang, XiaoYan, Hu, Jing, Zhang, XuKe, Guo, YuanQiang, Zhang, XueMei, Geng, ChangAn. The antidiabetic potency of Amomum tsao-ko and its active flavanols, as PTP1B selective and alpha-glucosidase dual inhibitors. INDUSTRIAL CROPS AND PRODUCTS[J]. 2021, 第 2 作者160: http://dx.doi.org/10.1016/j.indcrop.2020.112908.
[36] XiaoFeng He, JiJun Chen, TianZe Li, Jing Hu, XuKe Zhang, YuanQiang Guo, XueMei Zhang, ChangAn Geng. Tsaokols A and B,unusual flavanol-monoterpenoid hybrids asα-glucosidase inhibitors from Amomum tsao-ko. 中国化学快报:英文版[J]. 2021, 第 2 作者32(3): 1202-1205, http://lib.cqvip.com/Qikan/Article/Detail?id=7104944896.
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[268] 来国防, 陈纪军, 王易芬, 曹建新, 王慧英, 罗士德. 杜茎山属植物的研究进展. 中草药[J]. 2002, 第 2 作者33(6): 562-563, http://lib.cqvip.com/Qikan/Article/Detail?id=6424536.
[269] 来国防, 陈纪军, 罗士德. 紫菀属化学成分及药理活性研究进展. 天然产物研究与开发[J]. 2002, 第 2 作者65-70, http://lib.cqvip.com/Qikan/Article/Detail?id=1001074043.
[270] 来国防, 陈纪军. 黄酮类化合物抗HIV活性研究进展. 商丘师范学院学报[J]. 2002, 第 2 作者18(5): 83-87, http://lib.cqvip.com/Qikan/Article/Detail?id=6953255.
[271] 李云森, 罗士德, 陈纪军, 廖心荣, 王惠英. 雪山芪的化学成分研究. 中草药[J]. 2001, 第 3 作者32(6): 489-490, http://lib.cqvip.com/Qikan/Article/Detail?id=12375167.
[272] 王惠英, 许建初, 许敏, 罗士德, 陈纪军. 滇南红厚壳的化学成分. 云南植物研究[J]. 2001, 第 5 作者23(4): 521-526, http://lib.cqvip.com/Qikan/Article/Detail?id=5736557.
[273] 罗士德, 陈纪军, 张勉, 李云森, 王峥涛. 棉毛橐吾的化学成分. 中国中药杂志[J]. 2001, 第 2 作者26(12): 835-837, http://lib.cqvip.com/Qikan/Article/Detail?id=5809848.
[274] 王峥涛, 罗士德, 陈纪军, 张勉, 李云森. 干崖子橐吾的化学成分研究. 中国药科大学学报[J]. 2001, 第 3 作者32(5): 342, http://lib.cqvip.com/Qikan/Article/Detail?id=5584435.
[275] 陈纪军, 朱祯禄. 慈溪麦冬甙A和B的结构. 云南植物研究[J]. 2000, 第 1 作者22(1): 97-102, http://lib.cqvip.com/Qikan/Article/Detail?id=4607115.
[276] 朱祯禄, 陈纪军, 罗士德. 慈溪麦冬甙A和B的结构(英文). 云南植物研究[J]. 2000, 第 2 作者22(1): 97, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=820485&detailType=1.
[277] 钟海军, 陈纪军, 王惠英, 罗士德. 翻白叶的化学成分. 中草药[J]. 2000, 第 2 作者31(7): 488-490, http://lib.cqvip.com/Qikan/Article/Detail?id=4594556.
[278] 陈纪军, 张壮鑫. 通光藤甙F,G,H和I结构. 云南植物研究[J]. 1999, 第 1 作者21(3): 369-377, http://lib.cqvip.com/Qikan/Article/Detail?id=3698083.
[279] 陈金素, 陈纪军, 陈泗英, 周俊. 德钦红景天的化学成分. 云南植物研究[J]. 1999, 第 2 作者21(4): 525-530, http://lib.cqvip.com/Qikan/Article/Detail?id=3818617.
[280] 张壮鑫, 陈纪军, 周俊. 通光藤甙F,G ,H和I结构(英文). 云南植物研究. 1999, 第 2 作者21(3): 369, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=820443&detailType=1.
[281] 钟海军, 李雪琼, 王惠英, 罗士德, 陈纪军. 万丈深的化学成分. 云南植物研究[J]. 1999, 第 5 作者21(4): 531-534, http://lib.cqvip.com/Qikan/Article/Detail?id=3818618.
[282] 陈纪军, 李秉滔. 裂冠藤属--萝--科一新种. 华南农业大学学报. 自然科学版[J]. 1997, 第 1 作者18(1): 39, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=377072&detailType=1.
[283] 周俊, 吕扬, 郑启泰, 吴楠, 卢多, 陈纪军. 晶态下氯化氨甲酰胆碱结构研究. 天然产物研究与开发[J]. 1997, 第 6 作者9(4): 25, http://lib.cqvip.com/Qikan/Article/Detail?id=2721226.
[284] 何敏, 陈纪军, 周俊. 大白药的新三萜化合物. 云南植物研究[J]. 1992, 第 2 作者14(3): 323-327, http://lib.cqvip.com/Qikan/Article/Detail?id=930112.
[285] 陈纪军, 周俊, 周琳, 陶国达, 张壮鑫, 王德祖. ANovelC↓(12) Steroidal Glycoside From Marsdenia Incisa. 云南植物研究[J]. 1991, 第 1 作者13(2): 231, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=159939&detailType=1.
[286] 陈纪军, 周俊, 张壮鑫. 云南匙羹藤甙A和B的结构. 云南植物研究[J]. 1991, 第 1 作者13(1): 75, http://lib.cqvip.com/Qikan/Article/Detail?id=653347.
[287] 周俊, 陈纪军, 张壮鑫. 白首乌甙A、B、和C的结构. 云南植物研究[J]. 1990, 第 2 作者12(2): 197, http://www.irgrid.ac.cn/handle/1471x/432231.
[288] 张润珍, 陈纪军, 张壮鑫, 周俊. 裂冠牛奶菜的化学成分. 云南植物研究[J]. 1990, 第 2 作者12(1): 93, http://www.irgrid.ac.cn/handle/1471x/432729.
[289] 张壮鑫, 周俊, 陈纪军. 白首乌的化学成分. 云南植物研究[J]. 1989, 第 3 作者11(3): 358, http://www.irgrid.ac.cn/handle/1471x/432232.
[290] 陈纪军, 张壮鑫, 周俊. 大理白前的化学成分. 云南植物研究[J]. 1989, 第 1 作者11(4): 471, http://www.irgrid.ac.cn/handle/1471x/432319.
[291] 陈纪军, 周俊, 张壮鑫, 邱声祥. 云南匙羹藤的化学成分. 云南植物研究[J]. 1989, 第 1 作者11(2): 203, http://www.irgrid.ac.cn/handle/1471x/433276.
[292] 陈纪军, 张壮鑫, 周俊. 著名中药白首乌中的新c21甾体甙. 云南植物研究[J]. 1988, 第 1 作者10(4): 444, http://www.irgrid.ac.cn/handle/1471x/448400.
[293] ShengLi Wu, ChenChen Zhang, JiJun Chen, XueMei Zhang, Min Guan, ChangAn Geng. Oligostilbenes from the seeds of Paeonia lactiflora as potent GLP-1 secretagogues targeting TGR5 receptor. FITOTERAPIA. 第 3 作者http://dx.doi.org/10.1016/j.fitote.2022.105336.
[294] Wei Dong, KeXin Yang, XiaoFeng He, TianZe Li, JiJun Chen. New eudesmanolides from Artemisia verlotorum and their potential targets of hepatocellular carcinoma by network pharmacology. FITOTERAPIA. 第 5 作者  通讯作者  http://dx.doi.org/10.1016/j.fitote.2023.105491.
[295] ChangAn Geng, FengYang Chen, JingBin Zheng, Ping Liao, TianZe Li, XueMei Zhang, Xin Chen, JiJun Chen. Rubiginosin B selectively inhibits Treg cell differentiation and enhances anti-tumor immune responses by targeting calcineurin-NFAT signaling pathway. PHYTOMEDICINE. 第 8 作者  通讯作者  http://dx.doi.org/10.1016/j.phymed.2023.154898.
[296] Tian Wang, ShengLi Wu, Pei Liu, JiJun Chen, XueMei Zhang, ChangAn Geng. Diarylheptanoids with hypoglycemic potency from the rhizomes of Kaempferia galanga. FITOTERAPIA. 第 4 作者http://dx.doi.org/10.1016/j.fitote.2023.105502.
发表著作
(1) 抗艾滋病毒活性化合物, The Collection of Avtive Compounds of anti-HIV/AIDS, 云南科技出版社, 2002-05, 第 1 作者
(2) 中药资源化学, 科学出版社, 2015-10, 第 3 作者
(3) 三七临床研究, 科学出版社, 2016-03, 第 3 作者
(4) 三七植物化学, 科学出版社, 2017-03, 第 1 作者

科研活动

   
科研项目
( 1 ) 中药药效物质, 主持, 部委级, 2015-01--2017-12
( 2 ) 治疗抑郁症中药、天然药物1类新药奥生乐赛特胶囊的临床研究, 主持, 国家级, 2012-01--2015-12
( 3 ) 奥生乐赛特临床个性化研究, 主持, 部委级, 2015-10--2016-12
( 4 ) 抗精神疾病活性研究, 主持, 省级, 2016-01--2020-12
( 5 ) 中国科学院特聘研究员计划核心, 主持, 部委级, 2016-11--2019-12
( 6 ) 奥生乐赛特临床个性化研究(2017年度), 主持, 部委级, 2016-11--2017-12
( 7 ) 抗抑郁I类新药“奥生乐赛特”有关物质研究, 主持, 部委级, 2016-11--2020-12
( 8 ) 降血糖活性成分J306衍生物合成、构效关系及作用机制研究, 主持, 国家级, 2018-01--2021-12
( 9 ) “奥生乐赛特”原料药的有关物质研究, 主持, 市地级, 2017-11--2019-11
( 10 ) 抗抑郁症天然药物I类新药“奥生乐赛特”临床研究, 主持, 国家级, 2018-01--2020-12
( 11 ) 基于结构多样化天然化合物库的TNFR2小分子拮抗剂的发现和新型抗肿瘤免疫药物研发, 主持, 国家级, 2020-01--2022-12
( 12 ) 抗精神疾病和抗肝病药效物质与新药研发, 主持, 省级, 2020-01--2024-12
参与会议
(1)Naturally derived melatonin receptors agonists and their anti-depressant effects   第十三届天然化合物化学国际研讨会   2019-10-16
(2)天然抗抑郁活性先导分子的发现和药效评价   2019中国药物化学学术会议暨中欧药物化学研讨会   2019-08-15
(3)于褪黑素受体的抗抑郁活性化合物的发现   天然有机(药物)化学高峰论坛   2019-07-27
(4)基于褪黑素受体靶标的天然抗抑郁症先导化合物的发现   首届华西药学研讨会暨四川大学华西药学院100周年   2018-09-27
(5)Anti-HBV Constituents from Traditional Chinese Herbs   陈纪军   2017-10-26
(6)中药药效物质与药物开发   第三届中医科学大会   陈纪军   2016-09-05

指导学生

已指导学生

闫孟红  博士研究生  071001-植物学  

姚淑英  硕士研究生  100701-药物化学  

柳继锋  硕士研究生  071001-植物学  

常新亮  硕士研究生  071001-植物学  

程辟  博士研究生  071001-植物学  

王恩军  硕士研究生  100701-药物化学  

柳继锋  博士研究生  071001-植物学  

张泉  博士研究生  071001-植物学  

刘文峰  硕士研究生  100701-药物化学  

沈勇  博士研究生  100701-药物化学  

左爱学  博士研究生  100701-药物化学  

耿长安  博士研究生  100701-药物化学  

蒋富强  硕士研究生  077901-药物化学  

王立军  博士研究生  100701-药物化学  

何康  博士研究生  100701-药物化学  

王洪玲  博士研究生  100701-药物化学  

陈慧鑫  硕士研究生  077901-药物化学  

荣光庆  硕士研究生  077901-药物化学  

赵勇  硕士研究生  077901-药物化学  

梁文娟  博士研究生  100701-药物化学  

杨彩艳  博士研究生  100701-药物化学  

陈浩  博士研究生  100701-药物化学  

曹团武  博士研究生  100701-药物化学  

王豪  博士研究生  100701-药物化学  

许洪波  博士研究生  100701-药物化学  

杨通华  硕士研究生  078001-药物化学  

孙长利  博士研究生  100701-药物化学  

尹秀娟  博士研究生  100701-药物化学  

张建钢  硕士研究生  105500-药学  

陈兴龙  博士研究生  100701-药物化学  

张秀琼  硕士研究生  078001-药物化学  

颜得秀  硕士研究生  078001-药物化学  

邓振涛  博士研究生  100701-药物化学  

陈思月  硕士研究生  078001-药物化学  

张晨晨  硕士研究生  078001-药物化学  

何小凤  博士研究生  100701-药物化学  

苏丽花  博士研究生  100701-药物化学  

申程  硕士研究生  078001-药物化学  

唐爽  硕士研究生  078001-药物化学  

现指导学生

杨晓烔  博士研究生  100701-药物化学  

张心湉  硕士研究生  100706-药理学  

高振  博士研究生  100701-药物化学  

蔡英  博士研究生  100706-药理学  

张鑫  硕士研究生  078001-药物化学  

王远  博士研究生  100701-药物化学  

董伟  博士研究生  100701-药物化学  

卓悦  博士研究生  100701-药物化学  

商冲  硕士研究生  078001-药物化学  

王梦飞  博士研究生  100701-药物化学