分子免疫学

   

071009-细胞生物学
071005-微生物学

分子免疫学
分子病毒学

1988-03--1991-01   上海第二医科大学   博士研究生

1988.03-1991.01 

免疫学博士研究生，免疫学基础，上海第二医科大学

1983.07-1986.09 

硕士研究生，新疆医学院药理学专业

1978.10-1983.07 

本科，新疆医学院医疗系

2005.12- 2016.12       

中科院上海巴斯德所中方所长、研究员、研究组长。主要研究呼吸道流感病毒和SARS病毒感染的致病机制和抗HCV丙肝感染的免疫保护的机制研究。

1998.05-至今 

中科院上海生科院生化与细胞所研究员、研究组长

重点研究树突状细胞成熟与分化和T辅助细胞亚群（Th1和Th2细胞）分化。 

1994.01-1999.01 

美国国立卫生研究院博士后和高级访问学者

1991.01-1994.01 

上海第一医科大学药学院讲师、副教授

1986.09-1988.03 

    新疆医学院药学系助教

实验生物学
高级免疫学与病毒学系列讲座
抗体工程
分子病毒学

   

（1） 国家自然科学二等奖, 二等奖, 国家级, 2013
（2） 2012年度上海市自然科学二等奖, 二等奖, 省级, 2012
（3） “优秀研究生导师”奖, , 部委级, 2008
（4） 上海市优秀学科带头人, , 省级, 2007
（5） 千百万人才工程奖, , 国家级, 2004
（6） 上海市科技系统先进工作者, , 省级, 2004

[1] 孙兵, 孙晓玉, 伊春艳, 凌志洋, 张亚光. 抗冠状病毒的全人广谱中和抗体76E1及其应用. CN: CN114716541B, 2023-07-21.
[2] 孙兵, 范卫国, 张亚光, 凌志洋. ECM1基因敲除小鼠在抗肝纤维化药物筛选中的应用. CN: CN111154802B, 2023-05-02.
[3] 孙兵, 伊春艳, 凌志洋. 中和呼吸道合胞病毒的全人抗体的设计及应用. CN: CN115960214A, 2023-04-14.
[4] 孙兵, 孙晓玉, 伊春艳, 凌志洋, 张亚光. 抗冠状病毒的全人广谱中和抗体76E1及其应用. CN: CN114716541A, 2022-07-08.
[5] 孙兵, 伊春艳, 孙晓玉, 凌志洋, 张亚光. 针对SARS-CoV-2和SARS-CoV的全人广谱交叉中和抗体及其应用. CN: CN114685652A, 2022-07-01.
[6] 孙兵, 伊春艳, 孙晓玉, 凌志洋, 张亚光. 抗新冠病毒受体结合区域表位中和抗体及其应用. CN: CN114685653A, 2022-07-01.
[7] 孙兵, 孙晓玉, 卢晓, 凌志洋. 广谱性中和流感病毒的全人抗体. CN: CN111423507A, 2020-07-17.

   

[1] 孙兵. Serum ECM1 is a promising biomarker for staging and monitoring fibrosis in patients with chronic hepatitis B. 中国科学:生命科学(英文版)[J]. 2024, 第 1 作者  通讯作者  null(null): 
[2] Su Wang, Shufen Zhong, Ying Huang, Songling Zhu, Shuangfeng Chen, Ran Wang, Sonam Wangmo, Bo Peng, Houkun Lv, Jichao Yang, Liyan Ma, Zhiyang Ling, Yaguang Zhang, Pengfei Sui, Bing Sun. MDM2 Is Essential to Maintain the Homeostasis of Epithelial Cells by Targeting p53. JOURNAL OF INNATE IMMUNITY[J]. 2024, 第 15 作者  通讯作者  16(1): 397-412, https://doaj.org/article/824f3d6dab2643d292de67f3612b2047.
[3] 孙兵. Children exhibit a robust B-cell response to Omicron BA.2 after breakthrough infection with limited influence from the original antigenic sin. 中国免疫学杂志（英文版）[J]. 2024, 第 1 作者  通讯作者  null(null): 
[4] Wang, Zhishuo, Yan, Chenghua, Du, Qizhen, Huang, Yuying, Li, Xuezhen, Zeng, Dan, Mao, Ruizhi, Gurram, Rama Krishna, Cheng, Shipeng, Gu, Wangpeng, Zhu, Lin, Fan, Weiguo, Ma, Liyan, Ling, Zhiyang, Qiu, Ju, Li, Dangsheng, Liu, Enmei, Zhang, Yaguang, Fang, Yiru, Zhu, Jinfang, Sun, Bing. HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2023, 第 21 作者  通讯作者  http://dx.doi.org/10.1038/s41423-023-00982-6.
[5] Yuying Huang, Lin Zhu, Shipeng Cheng, Ranran Dai, Chunrong Huang, Yanyan Song, Bo Peng, Xuezhen Li, Jing Wen, Yi Gong, Yunqian Hu, Ling Qian, Linyun Zhu, Fengying Zhang, Li Yu, Chunyan Yi, Wangpeng Gu, Zhiyang Ling, Liyan Ma, Wei Tang, Li Peng, Guochao Shi, Yaguang Zhang, Bing Sun. Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis. NATURE COMMUNICATIONS[J]. 2023, 第 24 作者  通讯作者  14(1): 1-16, http://dx.doi.org/10.1038/s41467-023-41319-1.
[6] Yi, Chunyan, Su, Caixia, Sun, Xiaoyu, Lu, Xiao, Si, Chuanya, Liu, Caixuan, Yang, Zhuo, Yuan, Hong, Huang, Yuying, Wen, Jing, He, Yonghui, Zhang, Yaguang, Ma, Liyan, Cong, Yao, Zhao, Gan, Ling, Zhiyang, Wang, Bin, Sun, Bing. A human antibody potently neutralizes RSV by targeting the conserved hydrophobic region of prefusion F. SCIENCE CHINA-LIFE SCIENCES[J]. 2023, 第 18 作者  通讯作者  66(4): 1-14, http://dx.doi.org/10.1007/s11427-022-2250-0.
[7] Wangpeng Gu, Jia Zhang, Qing Li, Yaguang Zhang, Xuan Lin, Bingbing Wu, Qi Yin, Jinqiao Sun, Yulan Lu, Xiaoyu Sun, Caiwei Jia, Chuanyin Li, Yu Zhang, Meng Wang, Xidi Yin, Su Wang, Jiefang Xu, Ran Wang, Songling Zhu, Shipeng Cheng, Shuangfeng Chen, Lian Liu, Lin Zhu, Chenghua Yan, Chunyan Yi, Xuezhen Li, Qiaoshi Lian, Guomei Lin, Zhiyang Ling, Liyan Ma, Min Zhou, Kuanlin Xiao, Haiming Wei, Ronggui Hu, Wenhao Zhou, Lilin Ye, Haikun Wang, Jinsong Li, Bing Sun. The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation. CELL DISCOVERY[J]. 2023, 第 39 作者  通讯作者  9(1): 1-18, http://dx.doi.org/10.1038/s41421-023-00561-z.
[8] Wen, Jing, Cheng, Shipeng, Wang, Ran, Huang, Yuying, Xu, Long, Ma, Liyan, Ling, Zhiyang, Xu, Jinfu, Zhao, Deping, Zhang, Yaguang, Sun, Bing. Group 2 innate lymphoid cells boost CD8(+) T-cell activation in anti-tumor immune responses. ONCOIMMUNOLOGY[J]. 2023, 第 11 作者  通讯作者  12(1): http://dx.doi.org/10.1080/2162402X.2023.2243112.
[9] Zhu, Songling, Zhong, Shufen, Cheng, Kebin, Zhang, LiSha, Bai, Jiuwu, Cao, Zu, Wang, Su, Chen, Wen, Cheng, Shipeng, Ma, Liyan, Ling, Zhiyang, Huang, Yuying, Gu, Wangpeng, Sun, Xiaoyu, Yi, Chunyan, Zhao, Meng, Liang, Shuo, Xu, JinFu, Sun, Bing, Zhang, Yaguang. Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2023, 第 19 作者  通讯作者  20(7): 794-807, http://dx.doi.org/10.1038/s41423-023-01029-6.
[10] 凌志洋, 伊春艳, 孙晓玉, 杨卓, 孙兵. Broad strategies for neutralizing SARS-CoV-2 and other human coronaviruses with monoclonal antibodies. Science China Life Sciences[J]. 2022, 第 5 作者  通讯作者  
[11] Sun, Xiaoyu, Ling, Zhiyang, Yang, Zhuo, Sun, Bing. Broad neutralizing antibody-based strategies to tackle influenza. CURRENT OPINION IN VIROLOGY[J]. 2022, 第 4 作者  通讯作者  53: http://dx.doi.org/10.1016/j.coviro.2022.101207.
[12] Yi, Chunyan, Sun, Xiaoyu, Ling, Zhiyang, Sun, Bing. Jigsaw puzzle of SARS-CoV-2 RBD evolution and immune escape. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2022, 第 4 作者  通讯作者  19(7): 848-851, http://lib.cqvip.com/Qikan/Article/Detail?id=7108705430.
[13] Yi, Chunyan, Ling, Zhiyang, Lu, Xiao, Fu, Yadong, Yang, Zhuo, Wangmo, Sonam, Chen, Shuangfeng, Zhang, Yaguang, Ma, Liyan, Gu, Wangpeng, Lu, Hongzhou, Sun, Xiaoyu, Sun, Bing. A SARS-CoV-2 antibody retains potent neutralization against Omicron by targeting conserved RBM residues. CELLULAR & MOLECULAR IMMUNOLOGY. 2022, 第 13 作者  通讯作者  19(5): 647-649, http://lib.cqvip.com/Qikan/Article/Detail?id=7109300979.
[14] Chen, Wen, Chen, Shuangfeng, Yan, Chenghua, Zhang, Yaguang, Zhang, Ronghua, Chen, Min, Zhong, Shufen, Fan, Weiguo, Zhu, Songling, Zhang, Danyan, Lu, Xiao, Zhang, Jia, Huang, Yuying, Zhu, Lin, Li, Xuezhen, Lv, Dawei, Fu, Yadong, Houkun, Ling, Zhiyang, Ma, Liyan, Jiang, Hai, Long, Gang, Zhu, Jinfang, Wu, Dong, Wu, Bin, Sun, Bing. Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion. NATURE IMMUNOLOGY[J]. 2022, 第 26 作者  通讯作者  23(7): 1021-+, http://dx.doi.org/10.1038/s41590-022-01255-6.
[15] Sun, Xiaoyu, Liu, Caixuan, Lu, Xiao, Ling, Zhiyang, Yi, Chunyan, Zhang, Zhen, Li, Zi, Jin, Mingliang, Wang, Wenshuai, Tang, Shubing, Wang, Fangfang, Wang, Fang, Wangmo, Sonam, Chen, Shuangfeng, Li, Li, Ma, Liyan, Zhang, Yaguang, Yang, Zhuo, Dong, Xiaoping, Qian, Zhikang, Ding, Jianping, Wang, Dayan, Cong, Yao, Sun, Bing. Unique binding pattern for a lineage of human antibodies with broad reactivity against influenza A virus. NATURE COMMUNICATIONS[J]. 2022, 第 24 作者  通讯作者  13(1): http://dx.doi.org/10.1038/s41467-022-29950-w.
[16] Sun, Xiaoyu, Yi, Chunyan, Zhu, Yuanfei, Ding, Longfei, Xia, Shuai, Chen, Xingchen, Liu, Mu, Gu, Chenjian, Lu, Xiao, Fu, Yadong, Chen, Shuangfeng, Zhang, Tianlong, Zhang, Yaguang, Yang, Zhuo, Ma, Liyan, Gu, Wangpeng, Hu, Gaowei, Du, Shujuan, Yan, Renhong, Fu, Weihui, Yuan, Songhua, Qiu, Chenli, Zhao, Chen, Zhang, Xiaoyan, He, Yonghui, Qu, Aidong, Zhou, Xu, Li, Xiuling, Wong, Gary, Deng, Qiang, Zhou, Qiang, Lu, Hongzhou, Ling, Zhiyang, Ding, Jianping, Lu, Lu, Xu, Jianqing, Xie, Youhua, Sun, Bing. Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2. NATURE MICROBIOLOGY[J]. 2022, 第 38 作者  通讯作者  7(7): 1063-+, http://dx.doi.org/10.1038/s41564-022-01155-3.
[17] Qiaoshi Lian, Shanshan Yan, Qi Yin, Chenghua Yan, Wanwei Zheng, Wangpeng Gu, Xinhao Zhao, Weiguo Fan, Xuezhen Li, Liyan Ma, Zhiyang Ling, Yaguang Zhang, Jie Liu, Jinsong Li, Bing Sun. TRIM34 attenuates colon inflammation and tumorigenesis by sustaining barrier integrity. 中国免疫学杂志:英文版[J]. 2021, 第 15 作者18(2): 350-362, http://lib.cqvip.com/Qikan/Article/Detail?id=7104696550.
[18] Yi, Chunyan, Sun, Xiaoyu, Lin, Yixiao, Gu, Chenjian, Ding, Longfei, Lu, Xiao, Yang, Zhuo, Zhang, Yaguang, Ma, Liyan, Gu, Wangpeng, Qu, Aidong, Zhou, Xu, Li, Xiuling, Xu, Jianqing, Ling, Zhiyang, Xie, Youhua, Lu, Hongzhou, Sun, Bing. Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants. GENOME MEDICINE[J]. 2021, 第 18 作者  通讯作者  13(1): https://doaj.org/article/abd6694f3c9440cb879d9d5eacd4c115.
[19] Zhang, Yaguang, Li, Xuezhen, Luo, Zhongguang, Ma, Liyan, Zhu, Songling, Wang, Zhishuo, Wen, Jing, Cheng, Shipeng, Gu, Wangpeng, Lian, Qiaoshi, Zhao, Xinhao, Fan, Weiguo, Ling, Zhiyang, Ye, Jing, Zheng, Songguo, Li, Dangsheng, Wang, Hongyan, Liu, Jie, Sun, Bing. ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 第 19 作者  通讯作者  117(6): 3083-3092, http://dx.doi.org/10.1073/pnas.1912774117.
[20] Zhang, Yaguang, Xu, Jin, Jia, Ran, Yi, Chunyan, Gu, Wangpeng, Liu, Pengcheng, Dong, Xinran, Zhou, Hao, Shang, Bo, Cheng, Shipeng, Sun, Xiaoyu, Ye, Jing, Li, Xuezhen, Zhang, Jia, Ling, Zhiyang, Ma, Liyan, Wu, Bingbing, Zeng, Mei, Zhou, Wenhao, Sun, Bing. Protective humoral immunity in SARS-CoV-2 infected pediatric patients. CELLULAR & MOLECULAR IMMUNOLOGY. 2020, 第 20 作者  通讯作者  17(7): 768-770, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6905874&detailType=1.
[21] Zhong Jing. Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody.. Cell Mol Immunol.. 2020, 
[22] Fan, Weiguo, Liu, Tianhui, Chen, Wen, Hammad, Seddik, Longerich, Thomas, Hausser, Ingrid, Fu, Yadong, Li, Nan, He, Yajing, Liu, Cui, Zhang, Yaguang, Lian, Qiaoshi, Zhao, Xinhao, Yan, Chenghua, Li, Li, Yi, Chunyan, Ling, Zhiyang, Ma, Liyan, Zhao, Xinyan, Xu, Hufeng, Wang, Ping, Cong, Min, You, Hong, Liu, Zhihong, Wang, Yan, Chen, Jianfeng, Li, Dangsheng, Hui, Lijian, Dooley, Steven, Hou, Jinlin, Jia, Jidong, Sun, Bing. ECM1 Prevents Activation of Transforming Growth Factor beta, Hepatic Stellate Cells, and Fibrogenesis in Mice. GASTROENTEROLOGY[J]. 2019, 第 32 作者  通讯作者  157(5): 1352-+, http://dx.doi.org/10.1053/j.gastro.2019.07.036.
[23] He, Lan, Gu, Wangpeng, Wang, Meng, Chang, Xiaoyan, Sun, Xiaoyu, Zhang, Yuan, Lin, Xuan, Yan, Chenghua, Fan, Weiguo, Su, Pan, Wang, Yanming, Yi, Chunyan, Lin, Guomei, Li, Li, Jiang, Yu, Lu, Junxia, Dong, Chen, Wang, Haikun, Sun, Bing. Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 第 19 作者  通讯作者  115(34): 8621-8626, http://202.127.25.143/handle/331003/3403.
[24] Sun Bing. Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation. Cell Research. 2017, 第 1 作者  通讯作者  
[25] Lian, Qiaoshi, Sun, Bing. Interferons command Trim22 to fight against viruses. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2017, 第 2 作者  通讯作者  14(9): 794-796, 
[26] Yang, Chen, Zhao, Xinhao, Sun, Dakang, Yang, Leilei, Chong, Chang, Pan, Yu, Chi, Xiumei, Gao, Yanhang, Wang, Moli, Shi, Xiaodong, Sun, Haibo, Lv, Juan, Gao, Yuanda, Zhong, Jin, Niu, Junqi, Sun, Bing. Interferon alpha (IFN alpha)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2016, 第 16 作者  通讯作者  13(1): 94-102, https://www.webofscience.com/wos/woscc/full-record/WOS:000371996300010.
[27] Wenshuai Wang, Xiaoyu Sun, Yanbing Li, Jinpeng Su, Zhiyang Ling, Tianlong Zhang, Fang Wang, Hong Zhang, Hualan Chen, Jianping Ding, Bing Sun. Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses. NATURE COMMUNICATIONS[J]. 2016, 第 11 作者  通讯作者  7(1): https://doaj.org/article/133592a173724d4893bab2f4f11b4436.
[28] Su, Pan, Chen, Sheng, Zheng, Yu Han, Zhou, Hai Yan, Yan, Cheng Hua, Yu, Fang, Zhang, Ya Guang, He, Lan, Zhang, Yuan, Wang, Yanming, Wu, Lei, Wu, Xiaoai, Yu, Bingke, Ma, Li Yan, Yang, Zhiru, Wang, Jianhua, Zhao, Guixian, Zhu, Jinfang, Wu, ZhiYing, Sun, Bing. Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis. JOURNAL OF IMMUNOLOGY[J]. 2016, 第 20 作者  通讯作者  197(4): 1054-1064, https://www.webofscience.com/wos/woscc/full-record/WOS:000384999100007.
[29] Sun Bing. IFN-l4 desensitizes the response to IFN-a treatment in chronic hepatitis C through long-term induction of USP18. JOURNALOFGENERALVIROLOGY. 2016, 第 1 作者  通讯作者  
[30] Wang, Yanming, Lian, Qiaoshi, Yang, Bo, Yan, Shanshan, Zhou, Haiyan, He, Lan, Lin, Guomei, Lian, Zhexiong, Jiang, Zhengfan, Sun, Bing. TRIM30 alpha Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING. PLOS PATHOGENS[J]. 2015, 第 10 作者11(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000357400900064.
[31] Zhang, Ronghua, Wang, Kai, Ping, Xianqiang, Yu, Wenjing, Qian, Zhikang, Xiong, Sidong, Sun, Bing. The ns12.9 Accessory Protein of Human Coronavirus OC43 Is a Viroporin Involved in Virion Morphogenesis and Pathogenesis. JOURNAL OF VIROLOGY[J]. 2015, 第 7 作者89(22): 11383-11395, 
[32] Mao, Kairui, Chen, Shuzhen, Wang, Yan, Zeng, Yan, Ma, Yonglei, Hu, Yu, Zhang, Hong, Sun, Shuhui, Wu, Xiaodong, Meng, Guangxun, Pei, Gang, Sun, Bing. beta-arrestin1 Is Critical for the Full Activation of NLRP3 and NLRC4 Inflammasomes. JOURNAL OF IMMUNOLOGY[J]. 2015, 第 12 作者  通讯作者  194(4): 1867-1873, 
[33] Zhang, Hong, Han, Qinglin, Ping, Xianqiang, Li, Li, Chang, Chong, Chen, Ze, Shu, Yuelong, Xu, Ke, Sun, Bing. A single NS2 mutation of K86R promotes PR8 vaccine donor virus growth in Vero cells. VIROLOGY[J]. 2015, 第 9 作者  通讯作者  482(1): 32-40, http://dx.doi.org/10.1016/j.virol.2015.03.004.
[34] Hu, Weibin, Zhang, Hong, Han, Qinglin, Li, Li, Chen, Yixin, Xia, Ningshao, Chen, Ze, Shu, Yuelong, Xu, Ke, Sun, Bing. A Vero-cell-adapted vaccine donor strain of influenza A virus generated by serial passages. VACCINE[J]. 2015, 第 10 作者33(2): 374-381, http://dx.doi.org/10.1016/j.vaccine.2014.11.007.
[35] Wang, Yanming, Yan, Shanshan, Yang, Bo, Wang, Yan, Zhou, Haiyan, Lian, Qiaoshi, Sun, Bing. TRIM35 negatively regulates TLR7-and TLR9-mediated type I interferon production by targeting IRF7. FEBS LETTERS[J]. 2015, 第 7 作者  通讯作者  589(12): 1322-1330, http://dx.doi.org/10.1016/j.febslet.2015.04.019.
[36] Sun Bing. 2. Zhou HY, Wang YM, Lian QS, Yang B, Ma YL, Wu XD, Sun SH, Liu YJ, Sun B. Differential IL-10 production by DCs determines the distinct adjuvant effects of LPS and PTX in EAE induction.. 2014, 第 1 作者  通讯作者  
[37] Han, Qinglin, Chang, Chong, Li, Li, Klenk, Christoph, Cheng, Jinke, Chen, Yixin, Xia, Ningshao, Shu, Yuelong, Chen, Ze, Gabriel, Guelsah, Sun, Bing, Xu, Ke. Sumoylation of Influenza A Virus Nucleoprotein Is Essential for Intracellular Trafficking and Virus Growth. JOURNAL OF VIROLOGY[J]. 2014, 第 11 作者88(16): 9379-9390, http://dx.doi.org/10.1128/JVI.00509-14.
[38] Sha, Wenwen, Mitoma, Hiroki, Hanabuchi, Shino, Bao, Musheng, Weng, Leiyun, Sugimoto, Naoshi, Liu, Ying, Zhang, Zhiqiang, Zhong, Jin, Sun, Bing, Liu, YongJun. Human NLRP3 inflammasome senses multiple types of bacterial RNAs. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 第 10 作者  通讯作者  111(45): 16059-16064, https://www.webofscience.com/wos/woscc/full-record/WOS:000344526800054.
[39] Zhang, Hong, Li, Xuyong, Guo, Jing, Li, Li, Chang, Chong, Li, Yuanyuan, Bian, Chao, Xu, Ke, Chen, Hualan, Sun, Bing. The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virus. JOURNAL OF GENERAL VIROLOGY[J]. 2014, 第 10 作者  通讯作者  95: 779-786, http://dx.doi.org/10.1099/vir.0.061721-0.
[40] Sun Bing. 3. Zhang RH, Wang K, Lv W, Yu WJ, Xie SQ, Xu K, Schwarz W, Xiong SD, Sun B. The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production. Biochimica Et. 2014, 第 1 作者  通讯作者  
[41] Zhigang Tian, Jie Wang, Haiyan Zhou, Bo Yang, Xiaodong Wu, Bing Sun, Yanming Wang. Novel Function of Trim44 Promotes an Antiviral Response by Stabilizing VISA. AMERICAN ASSOCIATION OF IMMUNOLOGISTS. 2013, 第 6 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902027753308ZK.
[42] OuYang, Bo, Xie, Shiqi, Berardi, Marcelo J, Zhao, Xinhao, Dev, Jyoti, Yu, Wenjing, Sun, Bing, Chou, James J. Unusual architecture of the p7 channel from hepatitis C virus. NATURE[J]. 2013, 第 7 作者498(7455): 521-+, http://www.irgrid.ac.cn/handle/1471x/968497.
[43] Sun Bing. The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production.. Biochim Biophys Acta. 2013, 第 1 作者  通讯作者  
[44] Mao, Kairui, Chen, Shuzhen, Chen, Mingkuan, Ma, Yonglei, Wang, Yan, Huang, Bo, He, Zhengyu, Zeng, Yan, Hu, Yu, Sun, Shuhui, Li, Jing, Wu, Xiaodong, Wang, Xiangrui, Strober, Warren, Chen, Chang, Meng, Guangxun, Sun, Bing. Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. CELL RESEARCH[J]. 2013, 第 17 作者  通讯作者  23(2): 201-212, http://www.irgrid.ac.cn/handle/1471x/756526.
[45] Hu, Weibin, Chen, Aizhong, Miao, Yi, Xia, Shengli, Ling, Zhiyang, Xu, Ke, Wang, Tongyan, Xu, Ying, Cui, Jun, Wu, Hongqiang, Hu, Guiyu, Tian, Lin, Wang, Lingling, Shu, Yuelong, Ma, Xiaowei, Xu, Bianli, Zhang, Jin, Lin, Xiaojun, Bian, Chao, Sun, Bing. Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient. VIROLOGY[J]. 2013, 第 20 作者435(2): 320-328, http://dx.doi.org/10.1016/j.virol.2012.09.034.
[46] Bo Yang, Yanming Wang, Kairui Mao, Guomei Lin, Yuhan Zheng, Xiaodong Wu, Bing Sun, Yu Hu, Yongyong Ji, Yonglei Ma, Jie Wang, Haiyan Zhou, Leilei Yang. Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7. AMERICAN ASSOCIATION OF IMMUNOLOGISTS. 2013, 第 7 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902021366733ZK.
[47] Wang, Yan, Yang, Chen, Mao, Kairui, Chen, Shuzhen, Meng, Guangxun, Sun, Bing. Cellular localization of NLRP3 inflammasome. PROTEIN & CELL[J]. 2013, 第 6 作者4(6): 425-431, https://www.webofscience.com/wos/woscc/full-record/WOS:000320329700003.
[48] Wang, Kai, Lu, Wei, Chen, Jianfei, Xie, Shiqi, Shi, Hongyan, Hsu, Haojen, Yu, Wenjing, Xu, Ke, Bian, Chao, Fischer, Wolfgang B, Schwarz, Wolfgang, Feng, Li, Sun, Bing. PEDV ORF3 encodes an ion channel protein and regulates virus production. FEBS LETTERS[J]. 2012, 第 13 作者586(4): 384-391, http://dx.doi.org/10.1016/j.febslet.2012.01.005.
[49] Xu, Chen, Hu, WeiBin, Xu, Ke, He, YunXia, Wang, TongYan, Chen, Ze, Li, TianXian, Liu, JinHua, Buchy, Philippe, Sun, Bing. Amino acids 473V and 598P of PB1 from an avian-origin influenza A virus contribute to polymerase activity, especially in mammalian cells. JOURNAL OF GENERAL VIROLOGY[J]. 2012, 第 10 作者  通讯作者  93: 531-540, https://www.webofscience.com/wos/woscc/full-record/WOS:000301033600008.
[50] Sun Bing. Amino acids 473V and 598P of PB1 from an avian origin influenza A virus contribute to polymerase activity especially in mammalian cells.. 2011, 第 1 作者  通讯作者  
[51] Sun Bing. Extra-Cellular Matrix protein 1 controls Th2 cell egress from lymph nodes through re-expression of sphingosine 1-phosphate receptor 1. Nature Immunology. 2011, 第 1 作者  通讯作者  
[52] Xie, Shiqi, Wang, Kai, Yu, Wenjing, Lu, Wei, Xu, Ke, Wang, Jianwei, Ye, Bin, Schwarz, Wolfgang, Jin, Qi, Sun, Bing. DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71. CELL RESEARCH[J]. 2011, 第 10 作者  通讯作者  21(8): 1271-1275, http://lib.cqvip.com/Qikan/Article/Detail?id=38953173.
[53] Sun Bing. SUMO1 modification of the non-structural protein 1 of influenza A virus.. Journal of Virology. 2011, 第 1 作者  通讯作者  
[54] Shuzhen Chen, Xiaodong Wu, Shuhui Sun, Guangxun Meng, Zhiyun Tao, Chen Yang, Yu Hu, Kairui Mao, Bing Sun, Yan Zeng. Tripartite-Motif Protein 30 Negatively Regulates NLRP3 Inflammasome Activation by Modulating Reactive Oxygen Species Production. AMERICAN ASSOCIATION OF IMMUNOLOGISTS. 2010, 第 9 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902021667125ZK.
[55] He, Yuan, Xu, Ke, Keiner, Bjoern, Zhou, Jianfang, Czudai, Volker, Li, Tianxian, Chen, Ze, Liu, Jinhua, Klenk, HansDieter, Shu, Yue Long, Sun, Bing. Influenza A Virus Replication Induces Cell Cycle Arrest in G(0)/G(1) Phase. JOURNAL OF VIROLOGY[J]. 2010, 第 11 作者84(24): 12832-12840, http://dx.doi.org/10.1128/JVI.01216-10.
[56] Sun Bing. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment.. Nature Immunology. 2009, 第 1 作者  通讯作者  
[57] []. Dec2 Promotes Th2 Cell Differentiation by Enhancing IL-2R Signaling. AMERICAN ASSOCIATION OF IMMUNOLOGISTS. 2009, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902022166928ZK.
[58] Sun Bing. TRIM30a?negatively regulates TLR-mediated NF-kB activation by targeting TAB2 and TAB3 for degradation.. Nature Immunology. 2008, 第 1 作者  通讯作者  

（1） T辅助细胞的分化及其功能, T Helper Cell Differentiation and Their Function, springer, 2014-12, 第 1 作者

Execution period	Source	Name	Amount(RMB)
2009-2012	MOST	The pathogenicity of RNA polymerase and NS1 suppression   on IFN-α/ß production in different strains of avian flu viruses	2,600,000
2011-2015	MOHC	Detection technology of major infectious disease   emergency	1,910,000
2011-2015	MOHC	Prediction of hepatitis research	2,430,000
2011-2014	NSFC	ECM1 regulation of helper T cell subsets and   pathogenicity of migration	2,000,000
2012-2015	MOST（863）	Development of high-throughput immune cell chip   technology with single cell surface specific protein markers detection   instrument	720,000
2012-2015	MOST（863）	Mumps reduced key technology of attenuated vaccine and   product development	393,000
2013-2015	NSFC	New research NLRP3 inflammasome activation and   regulation mechanisms	2,810,000
2013-2014	CAS	Scientific research on human infection with avian   influenza H7N9 virus	700,000
2014-2015	CAS	Ebola virus disease emergency technology research	500,000
2014-2016	NSFC	Molecular mechanisms of T helper cell differentiation   and migration regulated by transcription factors of T-bet and GATA3 in immune   related diseases	1,800,000
2015-2016	NN-CAS	Treatment of EAE with Extracellular matrix protein 1(ECM1)   by inhibiting Th17 cell differentiation	500,000
2013-2017	MOST（973）	Study of functional T cell subsets and their associated   mechanisms of immune regulation	5,540,000
2015-2019	MOST（973）	Study on immune escape and immune pathology in Chronic   hepatitis C	820,000
2016-2021	MOST	Functional mechanism of protein machine during specific   immune response	2,000,000
2016-2021	MOST	Functional mechanism of protein machine during specific   immune response	1,419,500
2016	CAS	Establishment of screening platform for therapeutic   antibody targets and functional research of antibody	1,500,000
2017	CAS	Maturation of dendritic cells and differentiation mechanism   of Th2 cells in immune diseases	565,000
2017	CAS	Maturation of dendritic cells and differentiation   mechanism of Th2 cells in immune diseases	576,000
2017-2021	NSFC	The protective mechanism study for ECM1 to regulate the   function of macrophage in inflammatory bowel disease	3,442,000
2017-2021	NSFC	Novel long intergenic non-coding RNAs and transcription   factors inregulating the functions ofTh2 cells and type 2 innate lymphoid   cells in mouse models of asthma	1,700,000
2016-2019	SMSTC	Screeningculture and characterization research of   broad-spectrum human anti-influenza antibody	1,000,000

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