基本信息
孙兵  男  博导  中国科学院分子细胞科学卓越创新中心(生物化学与细胞生物学研究所)
电子邮件: bsun@sibs.ac.cn
通信地址: 岳阳路320号
邮政编码: 200031

研究领域

分子免疫学

招生信息

   
招生专业
071009-细胞生物学
071005-微生物学
招生方向
分子免疫学
分子病毒学

简历

1988-03--1991-01   上海第二医科大学   博士研究生
教育背景

1988.03-1991.01 

免疫学博士研究生,免疫学基础,上海第二医科大学

1983.07-1986.09 

硕士研究生,新疆医学院药理学专业

1978.10-1983.07 

本科,新疆医学院医疗系


工作经历

2005.12- 2016.12       

中科院上海巴斯德所中方所长、研究员、研究组长。主要研究呼吸道流感病毒和SARS病毒感染的致病机制和抗HCV丙肝感染的免疫保护的机制研究。

1998.05-至今 

中科院上海生科院生化与细胞所研究员、研究组长

重点研究树突状细胞成熟与分化和T辅助细胞亚群(Th1Th2细胞)分化。 

1994.01-1999.01 

美国国立卫生研究院博士后和高级访问学者

1991.01-1994.01 

上海第一医科大学药学院讲师、副教授

1986.09-1988.03 

    新疆医学院药学系助教


教授课程

实验生物学
高级免疫学与病毒学系列讲座
抗体工程
分子病毒学

专利与奖励

   
奖励信息
(1) 国家自然科学二等奖, 二等奖, 国家级, 2013
(2) 2012年度上海市自然科学二等奖, 二等奖, 省级, 2012
(3) “优秀研究生导师”奖, , 部委级, 2008
(4) 上海市优秀学科带头人, , 省级, 2007
(5) 千百万人才工程奖, , 国家级, 2004
(6) 上海市科技系统先进工作者, , 省级, 2004
专利成果
[1] 孙兵, 孙晓玉, 伊春艳, 凌志洋, 张亚光. 抗冠状病毒的全人广谱中和抗体76E1及其应用. CN: CN114716541B, 2023-07-21.
[2] 孙兵, 范卫国, 张亚光, 凌志洋. ECM1基因敲除小鼠在抗肝纤维化药物筛选中的应用. CN: CN111154802B, 2023-05-02.
[3] 孙兵, 伊春艳, 凌志洋. 中和呼吸道合胞病毒的全人抗体的设计及应用. CN: CN115960214A, 2023-04-14.
[4] 孙兵, 孙晓玉, 伊春艳, 凌志洋, 张亚光. 抗冠状病毒的全人广谱中和抗体76E1及其应用. CN: CN114716541A, 2022-07-08.
[5] 孙兵, 伊春艳, 孙晓玉, 凌志洋, 张亚光. 针对SARS-CoV-2和SARS-CoV的全人广谱交叉中和抗体及其应用. CN: CN114685652A, 2022-07-01.
[6] 孙兵, 伊春艳, 孙晓玉, 凌志洋, 张亚光. 抗新冠病毒受体结合区域表位中和抗体及其应用. CN: CN114685653A, 2022-07-01.
[7] 孙兵, 孙晓玉, 卢晓, 凌志洋. 广谱性中和流感病毒的全人抗体. CN: CN111423507A, 2020-07-17.

出版信息

   
发表论文
[1] Wang, Zhishuo, Yan, Chenghua, Du, Qizhen, Huang, Yuying, Li, Xuezhen, Zeng, Dan, Mao, Ruizhi, Gurram, Rama Krishna, Cheng, Shipeng, Gu, Wangpeng, Zhu, Lin, Fan, Weiguo, Ma, Liyan, Ling, Zhiyang, Qiu, Ju, Li, Dangsheng, Liu, Enmei, Zhang, Yaguang, Fang, Yiru, Zhu, Jinfang, Sun, Bing. HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2023, http://dx.doi.org/10.1038/s41423-023-00982-6.
[2] Yuying Huang, Lin Zhu, Shipeng Cheng, Ranran Dai, Chunrong Huang, Yanyan Song, Bo Peng, Xuezhen Li, Jing Wen, Yi Gong, Yunqian Hu, Ling Qian, Linyun Zhu, Fengying Zhang, Li Yu, Chunyan Yi, Wangpeng Gu, Zhiyang Ling, Liyan Ma, Wei Tang, Li Peng, Guochao Shi, Yaguang Zhang, Bing Sun. Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis. NATURE COMMUNICATIONS[J]. 2023, 14(1): 1-16, http://dx.doi.org/10.1038/s41467-023-41319-1.
[3] Yi, Chunyan, Su, Caixia, Sun, Xiaoyu, Lu, Xiao, Si, Chuanya, Liu, Caixuan, Yang, Zhuo, Yuan, Hong, Huang, Yuying, Wen, Jing, He, Yonghui, Zhang, Yaguang, Ma, Liyan, Cong, Yao, Zhao, Gan, Ling, Zhiyang, Wang, Bin, Sun, Bing. A human antibody potently neutralizes RSV by targeting the conserved hydrophobic region of prefusion F. SCIENCE CHINA-LIFE SCIENCES[J]. 2023, 66(4): 1-14, http://dx.doi.org/10.1007/s11427-022-2250-0.
[4] Wangpeng Gu, Jia Zhang, Qing Li, Yaguang Zhang, Xuan Lin, Bingbing Wu, Qi Yin, Jinqiao Sun, Yulan Lu, Xiaoyu Sun, Caiwei Jia, Chuanyin Li, Yu Zhang, Meng Wang, Xidi Yin, Su Wang, Jiefang Xu, Ran Wang, Songling Zhu, Shipeng Cheng, Shuangfeng Chen, Lian Liu, Lin Zhu, Chenghua Yan, Chunyan Yi, Xuezhen Li, Qiaoshi Lian, Guomei Lin, Zhiyang Ling, Liyan Ma, Min Zhou, Kuanlin Xiao, Haiming Wei, Ronggui Hu, Wenhao Zhou, Lilin Ye, Haikun Wang, Jinsong Li, Bing Sun. The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation. CELL DISCOVERY[J]. 2023, 9(1): 1-18, http://dx.doi.org/10.1038/s41421-023-00561-z.
[5] Wen, Jing, Cheng, Shipeng, Wang, Ran, Huang, Yuying, Xu, Long, Ma, Liyan, Ling, Zhiyang, Xu, Jinfu, Zhao, Deping, Zhang, Yaguang, Sun, Bing. Group 2 innate lymphoid cells boost CD8(+) T-cell activation in anti-tumor immune responses. ONCOIMMUNOLOGY[J]. 2023, 12(1): http://dx.doi.org/10.1080/2162402X.2023.2243112.
[6] Zhu, Songling, Zhong, Shufen, Cheng, Kebin, Zhang, LiSha, Bai, Jiuwu, Cao, Zu, Wang, Su, Chen, Wen, Cheng, Shipeng, Ma, Liyan, Ling, Zhiyang, Huang, Yuying, Gu, Wangpeng, Sun, Xiaoyu, Yi, Chunyan, Zhao, Meng, Liang, Shuo, Xu, JinFu, Sun, Bing, Zhang, Yaguang. Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2023, 20(7): 794-807, http://dx.doi.org/10.1038/s41423-023-01029-6.
[7] 凌志洋, 伊春艳, 孙晓玉, 杨卓, 孙兵. Broad strategies for neutralizing SARS-CoV-2 and other human coronaviruses with monoclonal antibodies. Science China Life Sciences[J]. 2022, [8] Sun, Xiaoyu, Ling, Zhiyang, Yang, Zhuo, Sun, Bing. Broad neutralizing antibody-based strategies to tackle influenza. CURRENT OPINION IN VIROLOGY[J]. 2022, 53: http://dx.doi.org/10.1016/j.coviro.2022.101207.
[9] Yi, Chunyan, Sun, Xiaoyu, Ling, Zhiyang, Sun, Bing. Jigsaw puzzle of SARS-CoV-2 RBD evolution and immune escape. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2022, 19(7): 848-851, http://dx.doi.org/10.1038/s41423-022-00884-z.
[10] Yi, Chunyan, Ling, Zhiyang, Lu, Xiao, Fu, Yadong, Yang, Zhuo, Wangmo, Sonam, Chen, Shuangfeng, Zhang, Yaguang, Ma, Liyan, Gu, Wangpeng, Lu, Hongzhou, Sun, Xiaoyu, Sun, Bing. A SARS-CoV-2 antibody retains potent neutralization against Omicron by targeting conserved RBM residues. CELLULAR & MOLECULAR IMMUNOLOGYnull. 2022, 19(5): 647-649, http://lib.cqvip.com/Qikan/Article/Detail?id=7109300979.
[11] Chen, Wen, Chen, Shuangfeng, Yan, Chenghua, Zhang, Yaguang, Zhang, Ronghua, Chen, Min, Zhong, Shufen, Fan, Weiguo, Zhu, Songling, Zhang, Danyan, Lu, Xiao, Zhang, Jia, Huang, Yuying, Zhu, Lin, Li, Xuezhen, Lv, Dawei, Fu, Yadong, Iv, Houkun, Ling, Zhiyang, Ma, Liyan, Jiang, Hai, Long, Gang, Zhu, Jinfang, Wu, Dong, Wu, Bin, Sun, Bing. Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion. NATURE IMMUNOLOGY[J]. 2022, 23(7): 1021-+, http://dx.doi.org/10.1038/s41590-022-01255-6.
[12] Sun, Xiaoyu, Liu, Caixuan, Lu, Xiao, Ling, Zhiyang, Yi, Chunyan, Zhang, Zhen, Li, Zi, Jin, Mingliang, Wang, Wenshuai, Tang, Shubing, Wang, Fangfang, Wang, Fang, Wangmo, Sonam, Chen, Shuangfeng, Li, Li, Ma, Liyan, Zhang, Yaguang, Yang, Zhuo, Dong, Xiaoping, Qian, Zhikang, Ding, Jianping, Wang, Dayan, Cong, Yao, Sun, Bing. Unique binding pattern for a lineage of human antibodies with broad reactivity against influenza A virus. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-29950-w.
[13] Sun, Xiaoyu, Yi, Chunyan, Zhu, Yuanfei, Ding, Longfei, Xia, Shuai, Chen, Xingchen, Liu, Mu, Gu, Chenjian, Lu, Xiao, Fu, Yadong, Chen, Shuangfeng, Zhang, Tianlong, Zhang, Yaguang, Yang, Zhuo, Ma, Liyan, Gu, Wangpeng, Hu, Gaowei, Du, Shujuan, Yan, Renhong, Fu, Weihui, Yuan, Songhua, Qiu, Chenli, Zhao, Chen, Zhang, Xiaoyan, He, Yonghui, Qu, Aidong, Zhou, Xu, Li, Xiuling, Wong, Gary, Deng, Qiang, Zhou, Qiang, Lu, Hongzhou, Ling, Zhiyang, Ding, Jianping, Lu, Lu, Xu, Jianqing, Xie, Youhua, Sun, Bing. Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2. NATURE MICROBIOLOGY[J]. 2022, 7(7): 1063-+, http://dx.doi.org/10.1038/s41564-022-01155-3.
[14] Qiaoshi Lian, Shanshan Yan, Qi Yin, Chenghua Yan, Wanwei Zheng, Wangpeng Gu, Xinhao Zhao, Weiguo Fan, Xuezhen Li, Liyan Ma, Zhiyang Ling, Yaguang Zhang, Jie Liu, Jinsong Li, Bing Sun. TRIM34 attenuates colon inflammation and tumorigenesis by sustaining barrier integrity. 中国免疫学杂志:英文版[J]. 2021, 18(2): 350-362, http://lib.cqvip.com/Qikan/Article/Detail?id=7104696550.
[15] Yi, Chunyan, Sun, Xiaoyu, Lin, Yixiao, Gu, Chenjian, Ding, Longfei, Lu, Xiao, Yang, Zhuo, Zhang, Yaguang, Ma, Liyan, Gu, Wangpeng, Qu, Aidong, Zhou, Xu, Li, Xiuling, Xu, Jianqing, Ling, Zhiyang, Xie, Youhua, Lu, Hongzhou, Sun, Bing. Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants. GENOME MEDICINE[J]. 2021, 13(1): http://dx.doi.org/10.1186/s13073-021-00985-w.
[16] Zhang, Yaguang, Li, Xuezhen, Luo, Zhongguang, Ma, Liyan, Zhu, Songling, Wang, Zhishuo, Wen, Jing, Cheng, Shipeng, Gu, Wangpeng, Lian, Qiaoshi, Zhao, Xinhao, Fan, Weiguo, Ling, Zhiyang, Ye, Jing, Zheng, Songguo, Li, Dangsheng, Wang, Hongyan, Liu, Jie, Sun, Bing. ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(6): 3083-3092, http://dx.doi.org/10.1073/pnas.1912774117.
[17] Zhang, Yaguang, Xu, Jin, Jia, Ran, Yi, Chunyan, Gu, Wangpeng, Liu, Pengcheng, Dong, Xinran, Zhou, Hao, Shang, Bo, Cheng, Shipeng, Sun, Xiaoyu, Ye, Jing, Li, Xuezhen, Zhang, Jia, Ling, Zhiyang, Ma, Liyan, Wu, Bingbing, Zeng, Mei, Zhou, Wenhao, Sun, Bing. Protective humoral immunity in SARS-CoV-2 infected pediatric patients. CELLULAR & MOLECULAR IMMUNOLOGYnull. 2020, 17(7): 768-770, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6905874&detailType=1.
[18] Zhong Jing. Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody.. Cell Mol Immunol.. 2020, [19] Fan, Weiguo, Liu, Tianhui, Chen, Wen, Hammad, Seddik, Longerich, Thomas, Hausser, Ingrid, Fu, Yadong, Li, Nan, He, Yajing, Liu, Cui, Zhang, Yaguang, Lian, Qiaoshi, Zhao, Xinhao, Yan, Chenghua, Li, Li, Yi, Chunyan, Ling, Zhiyang, Ma, Liyan, Zhao, Xinyan, Xu, Hufeng, Wang, Ping, Cong, Min, You, Hong, Liu, Zhihong, Wang, Yan, Chen, Jianfeng, Li, Dangsheng, Hui, Lijian, Dooley, Steven, Hou, Jinlin, Jia, Jidong, Sun, Bing. ECM1 Prevents Activation of Transforming Growth Factor beta, Hepatic Stellate Cells, and Fibrogenesis in Mice. GASTROENTEROLOGY[J]. 2019, 157(5): 1352-+, http://dx.doi.org/10.1053/j.gastro.2019.07.036.
[20] He, Lan, Gu, Wangpeng, Wang, Meng, Chang, Xiaoyan, Sun, Xiaoyu, Zhang, Yuan, Lin, Xuan, Yan, Chenghua, Fan, Weiguo, Su, Pan, Wang, Yanming, Yi, Chunyan, Lin, Guomei, Li, Li, Jiang, Yu, Lu, Junxia, Dong, Chen, Wang, Haikun, Sun, Bing. Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(34): 8621-8626, http://202.127.25.143/handle/331003/3403.
[21] Sun Bing. Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation. Cell Research. 2017, [22] Lian, Qiaoshi, Sun, Bing. Interferons command Trim22 to fight against viruses. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2017, 14(9): 794-796, [23] Yang, Chen, Zhao, Xinhao, Sun, Dakang, Yang, Leilei, Chong, Chang, Pan, Yu, Chi, Xiumei, Gao, Yanhang, Wang, Moli, Shi, Xiaodong, Sun, Haibo, Lv, Juan, Gao, Yuanda, Zhong, Jin, Niu, Junqi, Sun, Bing. Interferon alpha (IFN alpha)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2016, 13(1): 94-102, https://www.webofscience.com/wos/woscc/full-record/WOS:000371996300010.
[24] Wenshuai Wang, Xiaoyu Sun, Yanbing Li, Jinpeng Su, Zhiyang Ling, Tianlong Zhang, Fang Wang, Hong Zhang, Hualan Chen, Jianping Ding, Bing Sun. Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses. NATURE COMMUNICATIONS[J]. 2016, 7(1): https://doaj.org/article/133592a173724d4893bab2f4f11b4436.
[25] Su, Pan, Chen, Sheng, Zheng, Yu Han, Zhou, Hai Yan, Yan, Cheng Hua, Yu, Fang, Zhang, Ya Guang, He, Lan, Zhang, Yuan, Wang, Yanming, Wu, Lei, Wu, Xiaoai, Yu, Bingke, Ma, Li Yan, Yang, Zhiru, Wang, Jianhua, Zhao, Guixian, Zhu, Jinfang, Wu, ZhiYing, Sun, Bing. Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis. JOURNAL OF IMMUNOLOGY[J]. 2016, 197(4): 1054-1064, https://www.webofscience.com/wos/woscc/full-record/WOS:000384999100007.
[26] Sun Bing. IFN-l4 desensitizes the response to IFN-a treatment in chronic hepatitis C through long-term induction of USP18. JOURNALOFGENERALVIROLOGY. 2016, [27] Wang, Yanming, Lian, Qiaoshi, Yang, Bo, Yan, Shanshan, Zhou, Haiyan, He, Lan, Lin, Guomei, Lian, Zhexiong, Jiang, Zhengfan, Sun, Bing. TRIM30 alpha Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING. PLOS PATHOGENS[J]. 2015, 11(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000357400900064.
[28] Zhang, Ronghua, Wang, Kai, Ping, Xianqiang, Yu, Wenjing, Qian, Zhikang, Xiong, Sidong, Sun, Bing. The ns12.9 Accessory Protein of Human Coronavirus OC43 Is a Viroporin Involved in Virion Morphogenesis and Pathogenesis. JOURNAL OF VIROLOGY[J]. 2015, 89(22): 11383-11395, [29] Mao, Kairui, Chen, Shuzhen, Wang, Yan, Zeng, Yan, Ma, Yonglei, Hu, Yu, Zhang, Hong, Sun, Shuhui, Wu, Xiaodong, Meng, Guangxun, Pei, Gang, Sun, Bing. beta-arrestin1 Is Critical for the Full Activation of NLRP3 and NLRC4 Inflammasomes. JOURNAL OF IMMUNOLOGY[J]. 2015, 194(4): 1867-1873, [30] Zhang, Hong, Han, Qinglin, Ping, Xianqiang, Li, Li, Chang, Chong, Chen, Ze, Shu, Yuelong, Xu, Ke, Sun, Bing. A single NS2 mutation of K86R promotes PR8 vaccine donor virus growth in Vero cells. VIROLOGY[J]. 2015, 482(1): 32-40, http://dx.doi.org/10.1016/j.virol.2015.03.004.
[31] Hu, Weibin, Zhang, Hong, Han, Qinglin, Li, Li, Chen, Yixin, Xia, Ningshao, Chen, Ze, Shu, Yuelong, Xu, Ke, Sun, Bing. A Vero-cell-adapted vaccine donor strain of influenza A virus generated by serial passages. VACCINE[J]. 2015, 33(2): 374-381, http://dx.doi.org/10.1016/j.vaccine.2014.11.007.
[32] Wang, Yanming, Yan, Shanshan, Yang, Bo, Wang, Yan, Zhou, Haiyan, Lian, Qiaoshi, Sun, Bing. TRIM35 negatively regulates TLR7-and TLR9-mediated type I interferon production by targeting IRF7. FEBS LETTERS[J]. 2015, 589(12): 1322-1330, http://dx.doi.org/10.1016/j.febslet.2015.04.019.
[33] Sun Bing. 2. Zhou HY, Wang YM, Lian QS, Yang B, Ma YL, Wu XD, Sun SH, Liu YJ, Sun B. Differential IL-10 production by DCs determines the distinct adjuvant effects of LPS and PTX in EAE induction.. 2014, [34] Han, Qinglin, Chang, Chong, Li, Li, Klenk, Christoph, Cheng, Jinke, Chen, Yixin, Xia, Ningshao, Shu, Yuelong, Chen, Ze, Gabriel, Guelsah, Sun, Bing, Xu, Ke. Sumoylation of Influenza A Virus Nucleoprotein Is Essential for Intracellular Trafficking and Virus Growth. JOURNAL OF VIROLOGY[J]. 2014, 88(16): 9379-9390, http://dx.doi.org/10.1128/JVI.00509-14.
[35] Sha, Wenwen, Mitoma, Hiroki, Hanabuchi, Shino, Bao, Musheng, Weng, Leiyun, Sugimoto, Naoshi, Liu, Ying, Zhang, Zhiqiang, Zhong, Jin, Sun, Bing, Liu, YongJun. Human NLRP3 inflammasome senses multiple types of bacterial RNAs. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 111(45): 16059-16064, https://www.webofscience.com/wos/woscc/full-record/WOS:000344526800054.
[36] Zhang, Hong, Li, Xuyong, Guo, Jing, Li, Li, Chang, Chong, Li, Yuanyuan, Bian, Chao, Xu, Ke, Chen, Hualan, Sun, Bing. The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virus. JOURNAL OF GENERAL VIROLOGY[J]. 2014, 95: 779-786, http://dx.doi.org/10.1099/vir.0.061721-0.
[37] Sun Bing. 3. Zhang RH, Wang K, Lv W, Yu WJ, Xie SQ, Xu K, Schwarz W, Xiong SD, Sun B. The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production. Biochimica Et. 2014, [38] Zhigang Tian, Jie Wang, Haiyan Zhou, Bo Yang, Xiaodong Wu, Bing Sun, Yanming Wang. Novel Function of Trim44 Promotes an Antiviral Response by Stabilizing VISA. AMERICAN ASSOCIATION OF IMMUNOLOGISTS. 2013, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902027753308ZK.
[39] OuYang, Bo, Xie, Shiqi, Berardi, Marcelo J, Zhao, Xinhao, Dev, Jyoti, Yu, Wenjing, Sun, Bing, Chou, James J. Unusual architecture of the p7 channel from hepatitis C virus. NATURE[J]. 2013, 498(7455): 521-+, http://www.irgrid.ac.cn/handle/1471x/968497.
[40] Sun Bing. The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production.. Biochim Biophys Acta. 2013, [41] Hu, Weibin, Chen, Aizhong, Miao, Yi, Xia, Shengli, Ling, Zhiyang, Xu, Ke, Wang, Tongyan, Xu, Ying, Cui, Jun, Wu, Hongqiang, Hu, Guiyu, Tian, Lin, Wang, Lingling, Shu, Yuelong, Ma, Xiaowei, Xu, Bianli, Zhang, Jin, Lin, Xiaojun, Bian, Chao, Sun, Bing. Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient. VIROLOGY[J]. 2013, 435(2): 320-328, http://dx.doi.org/10.1016/j.virol.2012.09.034.
[42] Mao, Kairui, Chen, Shuzhen, Chen, Mingkuan, Ma, Yonglei, Wang, Yan, Huang, Bo, He, Zhengyu, Zeng, Yan, Hu, Yu, Sun, Shuhui, Li, Jing, Wu, Xiaodong, Wang, Xiangrui, Strober, Warren, Chen, Chang, Meng, Guangxun, Sun, Bing. Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. CELL RESEARCH[J]. 2013, 23(2): 201-212, http://www.irgrid.ac.cn/handle/1471x/756526.
[43] Bo Yang, Yanming Wang, Kairui Mao, Guomei Lin, Yuhan Zheng, Xiaodong Wu, Bing Sun, Yu Hu, Yongyong Ji, Yonglei Ma, Jie Wang, Haiyan Zhou, Leilei Yang. Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7. AMERICAN ASSOCIATION OF IMMUNOLOGISTS. 2013, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902021366733ZK.
[44] Wang, Yan, Yang, Chen, Mao, Kairui, Chen, Shuzhen, Meng, Guangxun, Sun, Bing. Cellular localization of NLRP3 inflammasome. PROTEIN & CELL[J]. 2013, 4(6): 425-431, https://www.webofscience.com/wos/woscc/full-record/WOS:000320329700003.
[45] Xu, Chen, Hu, WeiBin, Xu, Ke, He, YunXia, Wang, TongYan, Chen, Ze, Li, TianXian, Liu, JinHua, Buchy, Philippe, Sun, Bing. Amino acids 473V and 598P of PB1 from an avian-origin influenza A virus contribute to polymerase activity, especially in mammalian cells. JOURNAL OF GENERAL VIROLOGY[J]. 2012, 93: 531-540, https://www.webofscience.com/wos/woscc/full-record/WOS:000301033600008.
[46] Wang, Kai, Lu, Wei, Chen, Jianfei, Xie, Shiqi, Shi, Hongyan, Hsu, Haojen, Yu, Wenjing, Xu, Ke, Bian, Chao, Fischer, Wolfgang B, Schwarz, Wolfgang, Feng, Li, Sun, Bing. PEDV ORF3 encodes an ion channel protein and regulates virus production. FEBS LETTERS[J]. 2012, 586(4): 384-391, http://dx.doi.org/10.1016/j.febslet.2012.01.005.
[47] Sun Bing. Amino acids 473V and 598P of PB1 from an avian origin influenza A virus contribute to polymerase activity especially in mammalian cells.. 2011, [48] Sun Bing. Extra-Cellular Matrix protein 1 controls Th2 cell egress from lymph nodes through re-expression of sphingosine 1-phosphate receptor 1. Nature Immunology. 2011, [49] Xie, Shiqi, Wang, Kai, Yu, Wenjing, Lu, Wei, Xu, Ke, Wang, Jianwei, Ye, Bin, Schwarz, Wolfgang, Jin, Qi, Sun, Bing. DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71. CELL RESEARCH[J]. 2011, 21(8): 1271-1275, http://lib.cqvip.com/Qikan/Article/Detail?id=38953173.
[50] Sun Bing. SUMO1 modification of the non-structural protein 1 of influenza A virus.. Journal of Virology. 2011, [51] Shuzhen Chen, Xiaodong Wu, Shuhui Sun, Guangxun Meng, Zhiyun Tao, Chen Yang, Yu Hu, Kairui Mao, Bing Sun, Yan Zeng. Tripartite-Motif Protein 30 Negatively Regulates NLRP3 Inflammasome Activation by Modulating Reactive Oxygen Species Production. AMERICAN ASSOCIATION OF IMMUNOLOGISTS. 2010, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902021667125ZK.
[52] He, Yuan, Xu, Ke, Keiner, Bjoern, Zhou, Jianfang, Czudai, Volker, Li, Tianxian, Chen, Ze, Liu, Jinhua, Klenk, HansDieter, Shu, Yue Long, Sun, Bing. Influenza A Virus Replication Induces Cell Cycle Arrest in G(0)/G(1) Phase. JOURNAL OF VIROLOGY[J]. 2010, 84(24): 12832-12840, http://dx.doi.org/10.1128/JVI.01216-10.
[53] Sun Bing. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment.. Nature Immunology. 2009, [54] []. Dec2 Promotes Th2 Cell Differentiation by Enhancing IL-2R Signaling. AMERICAN ASSOCIATION OF IMMUNOLOGISTS. 2009, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902022166928ZK.
[55] Sun Bing. TRIM30a?negatively regulates TLR-mediated NF-kB activation by targeting TAB2 and TAB3 for degradation.. Nature Immunology. 2008, 
发表著作
(1) T辅助细胞的分化及其功能, T Helper Cell Differentiation and Their Function, springer, 2014-12, 第 1 作者

项目承担情况

Execution period

Source

Name

Amount(RMB)

2009-2012

MOST

The pathogenicity of RNA polymerase and NS1 suppression   on IFN-α/ß production in different strains of avian flu viruses

2,600,000

2011-2015

MOHC

Detection technology of major infectious disease   emergency

1,910,000

2011-2015

MOHC

Prediction of hepatitis research

2,430,000

2011-2014

NSFC

ECM1 regulation of helper T cell subsets and   pathogenicity of migration

2,000,000

  2012-2015

MOST863

Development of high-throughput immune cell chip   technology with single cell surface specific protein markers detection   instrument

720,000

2012-2015

MOST863

Mumps reduced key technology of attenuated vaccine and   product development

393,000

2013-2015

NSFC

New research NLRP3 inflammasome activation and   regulation mechanisms

2,810,000

2013-2014

CAS

Scientific research on human infection with avian   influenza H7N9 virus

700,000

2014-2015

CAS

Ebola virus disease emergency technology research

500,000

2014-2016

NSFC

Molecular mechanisms of T helper cell differentiation   and migration regulated by transcription factors of T-bet and GATA3 in immune   related diseases

1,800,000

2015-2016

NN-CAS

Treatment of EAE with Extracellular matrix protein 1(ECM1)   by inhibiting Th17 cell differentiation

500,000

2013-2017

MOST973

Study of functional T cell subsets and their associated   mechanisms of immune regulation

5,540,000

2015-2019

MOST973

Study on immune escape and immune pathology in Chronic   hepatitis C

820,000

2016-2021

MOST

Functional mechanism of protein machine during specific   immune response

2,000,000

2016-2021

MOST

Functional mechanism of protein machine during specific   immune response

1,419,500

2016

CAS

Establishment of screening platform for therapeutic   antibody targets and functional research of antibody

1,500,000

2017

CAS

Maturation of dendritic cells and differentiation mechanism   of Th2 cells in immune diseases

565,000

2017

CAS

Maturation of dendritic cells and differentiation   mechanism of Th2 cells in immune diseases

576,000

2017-2021

NSFC

The protective mechanism study for ECM1 to regulate the   function of macrophage in inflammatory bowel disease

3,442,000

2017-2021

NSFC

Novel long intergenic non-coding RNAs and transcription   factors inregulating the functions ofTh2 cells and type 2 innate lymphoid   cells in mouse models of asthma

1,700,000

2016-2019

SMSTC

Screeningculture and characterization research of   broad-spectrum human anti-influenza antibody

1,000,000


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