基本信息
薛愿超 男 博导 生物物理研究所
电话:15652394680 ,010-64888447
电子邮件:xueyuanchao@hotmail.com
单位名称:中国科学院生物物理所,中国科学院核酸生物学重点实验室
通信地址:北京市朝阳区大屯路15号
邮政编码:100101

研究领域

RNA结合蛋白,非编码RNA,细胞转分化

招生信息

生物化学与分子生物学、生物信息学、细胞生物学

招生专业
071010-生物化学与分子生物学
招生方向
RNA结合蛋白和非编码RNA与细胞命运决定

教育背景

   
学历
2000-2004  信阳师范学院, 获理学学士学位

2004-2009  武汉大学, 获理学博士学位

2010-2015  美国加州大学圣地亚哥分校博士后
学位

博士

专利与奖励

2015年度中组部“青年****”、2015年度“国家优秀青年科学基金

出版信息

   
发表论文
[1] Gu, Zhongru, Pan, Shengkai, Lin, Zhenzhen, Hu, Li, Dai, Xiaoyang, Chang, Jiang, Xue, Yuanchao, Su, Han, Long, Juan, Sun, Mengru, Ganusevich, Sergey, Sokolov, Vasiliy, Sokolov, Aleksandr, Pokrovsky, Ivan, Ji, Fen, Bruford, Michael W, Dixon, Andrew, Zhan, Xiangjiang. Climate-driven flyway changes and memory-based long-distance migration. NATURE[J]. 2021, 591(7849): 259-+, http://dx.doi.org/10.1038/s41586-021-03265-0.
[2] Zhang, Jinyang, Hou, Lingling, Zuo, Zhenqiang, Ji, Peifeng, Zhang, Xiaorong, Xue, Yuanchao, Zhao, Fangqing. Comprehensive profiling of circular RNAs with nanopore sequencing and CIRI-long. NATURE BIOTECHNOLOGY[J]. 2021, 39(7): 836-845, http://dx.doi.org/10.1038/s41587-021-00842-6.
[3] Cao, Changchang, Cai, Zhaokui, Xiao, Xia, Rao, Jian, Chen, Juan, Hu, Naijing, Yang, Minnan, Xing, Xiaorui, Wang, Yongle, Li, Manman, Zhou, Bing, Wang, Xiangxi, Wang, Jianwei, Xue, Yuanchao. The architecture of the SARS-CoV-2 RNA genome inside virion. NATURE COMMUNICATIONS[J]. 2021, 12(1): http://dx.doi.org/10.1038/s41467-021-22785-x.
[4] Cao, Changchang, Cai, Zhaokui, Ye, Rong, Su, Ruibao, Hu, Naijing, Zhao, Hailian, Xue, Yuanchao. Global in situ profiling of RNA-RNA spatial interactions with RIC-seq. NATURE PROTOCOLS[J]. 2021, 16(6): 2916-2946, http://dx.doi.org/10.1038/s41596-021-00524-2.
[5] Su, Ruibao, Fan, LiHua, Cao, Changchang, Wang, Lei, Du, Zongchang, Cai, Zhaokui, Ouyang, YingChun, Wang, Yue, Zhou, Qian, Wu, Ligang, Zhang, Nan, Zhu, Xiaoxiao, Lei, WenLong, Zhao, Hailian, Tian, Yong, He, Shunmin, Wong, Catherine C L, Sun, QingYuan, Xue, Yuanchao. Global profiling of RNA-binding protein target sites by LACE-seq. NATURE CELL BIOLOGY[J]. 2021, 23(6): 664-+, [6] Liu, Jingjing, You, Menghao, Yao, Yingpeng, Ji, Ce, Wang, Zhao, Wang, Fang, Wang, Di, Qi, Zhihong, Yu, Guotao, Sun, Zhen, Guo, Wenhui, Liu, Juanjuan, Li, Shumin, Jin, Yipeng, Zhao, Tianyan, Xue, HaiHui, Xue, Yuanchao, Yu, Shuyang. SRSF1 plays a critical role in invariant natural killer T cell development and function. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2021, 18(11): 2502-2515, http://dx.doi.org/10.1038/s41423-021-00766-w.
[7] Qian, Hao, Kang, Xinjiang, Hu, Jing, Zhang, Dongyang, Liang, Zhengyu, Meng, Fan, Zhang, Xuan, Xue, Yuanchao, Maimon, Roy, Dowdy, Steven F, Devaraj, Neal K, Zhou, Zhuan, Mobley, William C, Cleveland, Don W, Fu, XiangDong. Reversing a model of Parkinson's disease with in situ converted nigral neurons. NATURE[J]. 2020, 582(7813): 550-+, http://dx.doi.org/10.1038/s41586-020-2388-4.
[8] Li, Yaoyi, Song, Yawei, Xu, Wei, Li, Qin, Wang, Xinxiu, Li, Kuan, Wang, Juehan, Liu, Zicong, Velychko, Sergiy, Ye, Rong, Xia, Qing, Wang, Lei, Guo, Rong, Dong, Xiaotao, Zheng, Zhikai, Dai, Yushuang, Li, Haojie, Yao, Mingze, Xue, Yuanchao, Schoeler, Hans R, Sun, Qianwen, Yao, Hongjie. R-loops coordinate with SOX2 in regulating reprogramming to pluripotency. SCIENCE ADVANCES[J]. 2020, 6(24): http://dx.doi.org/10.1126/sciadv.aba0777.
[9] Xue, Yuanchao, Chen, Runsheng, Qu, Lianghu, Cao, Xiaofeng. Noncoding RNA: from dark matter to bright star. SCIENCE CHINA-LIFE SCIENCES. 2020, 63(4): 463-468, http://lib.cqvip.com/Qikan/Article/Detail?id=7101497800.
[10] Cai, Zhaokui, Cao, Changchang, Ji, Lei, Ye, Rong, Wang, Di, Xia, Cong, Wang, Sui, Du, Zongchang, Hu, Naijing, Yu, Xiaohua, Chen, Juan, Wang, Lei, Yang, Xianguang, He, Shunmin, Xue, Yuanchao. RIC-seq for global in situ profiling of RNA-RNA spatial interactions. NATURE[J]. 2020, 582(7812): 432-+, http://dx.doi.org/10.1038/s41586-020-2249-1.
[11] Ye, Rong, Cao, Changchang, Xue, Yuanchao, Du, X. Enhancer RNA: biogenesis, function, and regulation. SPOTLIGHT ON CHINA: RNAnull. 2020, 64(6): 883-894, http://dx.doi.org/10.1042/EBC20200014.
[12] Hu, Jing, Gao, Chen, Wei, Chaoliang, Xue, Yuanchao, Shao, Changwei, Hao, Yajing, Gou, LanTao, Zhou, Yu, Zhang, Jianlin, Ren, Shuxun, Chen, Ju, Wang, Yibin, Fu, XiangDong. RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 116(13): 6172-6180, [13] Li, Zonghong, Zhou, Maoge, Cai, Zhaokui, Liu, Hongyang, Zhong, Wen, Hao, Qiang, Cheng, Dongwan, Hu, Xihao, Hou, Junjie, Xu, Pingyong, Xue, Yuanchao, Zhou, Yifa, Xu, Tao. RNA-binding protein DDX1 is responsible for fatty acid-mediated repression of insulin translation. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(22): 12052-12066, https://www.webofscience.com/wos/woscc/full-record/WOS:000456714000035.
[14] Juan Chen, Zhaokui Cai, Meizhu Bai, Xiaohua Yu, Chao Zhang, Changchang Cao, Xihao Hu, Lei Wang, Ruibao Su, Di Wang, Yingpeng Yao, Rong Ye, Baidong Hou, Yang Yu, Shuyang Yu, Jinsong Li, Yuanchao xue. The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes. 细胞研究:英文版[J]. 2018, 28(10): 981-995, http://lib.cqvip.com/Qikan/Article/Detail?id=676732340.
[15] Hu Jing, Qian Hao, Xue Yuanchao, Fu Xiangdong. PTB/nPTB: master regulators of neuronal fate in mammals. 生物物理学报:英文版[J]. 2018, 4(4): 204-214, http://lib.cqvip.com/Qikan/Article/Detail?id=676327038.
[16] Zhang, Kai, Zhang, Xiaorong, Cai, Zhiqiang, Zhou, Jie, Cao, Ran, Zhao, Ya, Chen, Zonggui, Wang, Dehe, Ruan, Wen, Zhao, Qian, Liu, Guangqiao, Xue, Yuanchao, Qin, Yan, Zhou, Bing, Wu, Ligang, Nilsen, Timothy, Zhou, Yu, Fu, XiangDong. A novel class of microRNA-recognition elements that function only within open reading frames. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2018, 25(11): 1019-+, http://202.127.25.143/handle/331003/3372.
[17] Jing Hu, Hao Qian, Yuanchao Xue, Xiang-Dong Fu. PTB/nPTB: master regulators of neuronal fate in mammals. 生物物理学报:英文版[J]. 2018, 4(4): 204-214, http://lib.cqvip.com/Qikan/Article/Detail?id=676327038.
[18] Chen, Juan, Cai, Zhaokui, Bai, Meizhu, Yu, Xiaohua, Zhang, Chao, Cao, Changchang, Hu, Xihao, Wang, Lei, Su, Ruibao, Wang, Di, Yao, Yingpeng, Ye, Rong, Hou, Baidong, Yu, Yang, Yu, Shuyang, Li, Jinsong, Xue, Yuanchao. The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes. CELL RESEARCH[J]. 2018, 28(10): 981-995, http://202.127.25.143/handle/331003/3502.
[19] Burkholder, Nathaniel Tate, Mayfield, Joshua E, Yu, Xiaohua, Irani, Seema, Arce, Daniel K, Jiang, Faqin, Matthews, Wendy L, Xue, Yuanchao, Zhang, Yan Jessie. Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST). JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2018, 293(43): 16851-16861, http://dx.doi.org/10.1074/jbc.RA118.004722.
[20] Liu, Chang, Xin, Ying, Xu, Le, Cai, Zhaokui, Xue, Yuanchao, Liu, Yong, Xie, Daoxin, Liu, Yule, Qi, Yijun. Arabidopsis ARGONAUTE 1 Binds Chromatin to Promote Gene Transcription in Response to Hormones and Stresses. DEVELOPMENTAL CELL[J]. 2018, 44(3): 348-+, http://dx.doi.org/10.1016/j.devcel.2017.12.002.
[21] 赵爽, 陈月琴, 薛愿超, 周宇, 刘默芳. RNA-蛋白质机器在哺乳动物遗传信息表达中的调控功能与机制. 中国基础科学[J]. 2018, 20(3): 8-12, http://lib.cqvip.com/Qikan/Article/Detail?id=676330462.
[22] Xue, Yuanchao, Qian, Hao, Hu, Jing, Zhou, Bing, Zhou, Yu, Hu, Xihao, Karakhanyan, Aziz, Pang, Zhiping, Fu, XiangDong. Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells. NATURE NEUROSCIENCE[J]. 2016, 19(6): 807-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000376744600011.
[23] Lim, Su Min, Choi, Won Jun, Oh, KiWook, Xue, Yuanchao, Choi, Ji Young, Kim, Sung Hoon, Nahm, Minyeop, Kim, YoungEun, Lee, Jinhyuk, Noh, MinYoung, Lee, Seungbok, Hwang, Sejin, Ki, ChangSeok, Fu, XiangDong, Kim, Seung Hyun. Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis. MOLECULAR NEURODEGENERATION[J]. 2016, 11(1): http://dx.doi.org/10.1186/s13024-016-0075-6.
[24] Chen, Juan, Xue, Yuanchao. Emerging roles of non-coding RNAs in epigenetic regulation. SCIENCE CHINA-LIFE SCIENCES[J]. 2016, 59(3): 227-235, https://www.webofscience.com/wos/woscc/full-record/WOS:000371799800002.
[25] Lim, Su Min, Choi, ByungOk, Oh, SeongIl, Choi, Won Jun, Oh, KiWook, Nahm, Minyeop, Xue, Yuanchao, Choi, Jae Hyeok, Choi, Ji Young, Kim, YoungEun, Chung, Ki Wha, Fu, XiangDong, Ki, ChangSeok, Kim, Seung Hyun. Patient fibroblasts-derived induced neurons demonstrate autonomous neuronal defects in adult-onset Krabbe disease. ONCOTARGET[J]. 2016, 7(46): 74496-74509, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000389632800008.
[26] Wei, Chaoliang, Xiao, Rui, Chen, Liang, Cui, Hanwei, Zhou, Yu, Xue, Yuanchao, Hu, Jing, Zhou, Bing, Tsutsui, Taiki, Qiu, Jinsong, Li, Hairi, Tang, Liling, Fu, XiangDong. RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes. MOLECULAR CELL[J]. 2016, 62(6): 875-889, http://dx.doi.org/10.1016/j.molcel.2016.06.003.
[27] 陈润生. MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes. CELL RESEARCH[J]. 2015, 25(2): 193-207, http://dx.doi.org/10.1038/cr.2015.4.
[28] Ouyang, Hong, Xue, Yuanchao, Lin, Ying, Zhang, Xiaohui, Xi, Lei, Patel, Sherrina, Cai, Huimin, Luo, Jing, Zhang, Meixia, Zhang, Ming, Yang, Yang, Li, Gen, Li, Hairi, Jiang, Wei, Yeh, Emily, Lin, Jonathan, Pei, Michelle, Zhu, Jin, Cao, Guiqun, Zhang, Liangfang, Yu, Benjamin, Chen, Shaochen, Fu, XiangDong, Liu, Yizhi, Zhang, Kang. WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis. NATURE[J]. 2014, 511(7509): 358-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000338992200038.
[29] Gou, LanTao, Dai, Peng, Yang, JianHua, Xue, Yuanchao, Hu, YunPing, Zhou, Yu, Kang, JunYan, Wang, Xin, Li, Hairi, Hua, MinMin, Zhao, Shuang, Hu, SiDa, Wu, LiGang, Shi, HuiJuan, Li, Yong, Fu, XiangDong, Qu, LiangHu, Wang, EnDuo, Liu, MoFang. Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis. CELL RESEARCH[J]. 2014, 24(6): 680-700, http://dx.doi.org/10.1038/cr.2014.41.
[30] Xue, Yuanchao, Ouyang, Kunfu, Huang, Jie, Zhou, Yu, Ouyang, Hong, Li, Hairi, Wang, Gang, Wu, Qijia, Wei, Chaoliang, Bi, Yanzhen, Jiang, Li, Cai, Zhiqiang, Sun, Hui, Zhang, Kang, Zhang, Yi, Chen, Ju, Fu, XiangDong. Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits. CELL[J]. 2013, 152(1-2): 82-96, http://dx.doi.org/10.1016/j.cell.2012.11.045.
[31] Xue, Yuanchao, Zhou, Yu, Wu, Tongbin, Zhu, Tuo, Ji, Xiong, Kwon, YoungSoo, Zhang, Chao, Yeo, Gene, Black, Douglas L, Sun, Hui, Fu, XiangDong, Zhang, Yi. Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping. MOLECULAR CELL[J]. 2009, 36(6): 996-1006, http://dx.doi.org/10.1016/j.molcel.2009.12.003.

指导学生

现指导学生

蔡兆奎  博士研究生  071010-生物化学与分子生物学