基本信息
刘钢  男  博导  中国科学院微生物研究所
电子邮件: liug@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院
邮政编码: 100101

研究领域

1. 微生物次级代谢与调控;
2. 基因编辑。

招生信息

招生专业:
071007 遗传学

招生方向
真菌次级代谢与其调控
微生物基因编辑

教育背景

1995-09--1998-08   中国科学院微生物研究所   理学博士
1992-09--1995-07   南开大学   理学硕士
1988-09--1992-07   南开大学   理学学士
学历
-- 研究生
学位
-- 博士
出国学习工作
1998-2001, 作为博士后研究人员,曾先后在西班牙Leon大学J.F.Martin实验室从事青霉素以及头孢菌素等β-内酰胺类抗生素生物合成调控的研究,以及在美国Texas A&M大学植物病理及微生物系从事植物内生真菌Epichloe festucae的次生代谢物loline的生物合成及其调控研究。

工作经历

2001年至今,在中科院微生物研究所从事微生物次级代谢产物的生物合成及其调控机制研究。
工作简历
2007-05~现在, 中国科学院微生物研究所, 研究员
2001-10~2007-04,中国科学院微生物研究所, 副研究员
2000-05~2001-10,美国TEXAS A§M 大学, 博士后
1998-09~2000-05,西班牙LEON大学, 博士后
社会兼职
2019-05-01-2024-04-30,中国遗传学会微生物遗传专业委员会, 委员
2018-11-30-2023-12-01,国家卫生健康委员会抗生素生物工程重点实验室第三届学术委员会, 委员
2018-08-01-2023-07-31,《菌物研究》, 编委
2018-01-01-2021-12-31,菌物学报, 编委
2017-01-01-2019-12-31,《遗传》, 编委
2016-09-30-2021-09-30,中国微生物学会科学普及工作委员会, 委员
2015-05-01-2020-04-30,《化学与生物工程》, 编委
2011-12-29-2021-10-01,微生物学报, 编委
2011-09-28-2021-09-29,中国微生物学会分子生物学与生物工程专业委员会, 委员

教授课程

微生物遗传与分子生物学
真菌次级代谢与调控
抗生素的生物合成及其调控
尼可霉素生物合成的代谢调控
分子遗传学-微生物遗传

专利与奖励

   
奖励信息
(1) 研究生优秀课程, 研究所(学校), 2019
(2) 中国科学院大学生命科学学院精品课程, 院级, 2018
专利成果
[1] 刘钢, 刘佳佳. 一种生产头孢菌素C的重组菌及其应用. CN: CN107201318B, 2020-04-21.

[2] 刘钢, 刘佳佳. 一株不依赖于甲硫氨酸的头孢菌素高产基因工程菌株的构建及其应用. CN: CN105524849B, 2019-02-12.

[3] 刘钢, 李淑贤, 俞灵军. SCO6974基因缺失天蓝色链霉菌及其在提高抗生素产量的应用. 中国: CN103881951A, 2014.06.25.

[4] 刘钢, 龙良鲲, 刘莉. 一种顶头孢霉工程菌及其构建方法. 中国: CN102719473A, 2012-10-10.

[5] 刘钢, 安洋. 生产高纯度头孢菌素C的基因工程菌及其应用. 中国: CN102174420A, 2011-09-07.

[6] 谭华荣, 刘钢. 尼可霉素生物合成调控基因及其编码蛋白与表达工程菌. 中国: CN100347302, 2007-11-07.

出版信息

   
发表论文
[1] Li, Hong, Pan, Yuanyuan, Liu, Gang. Multiplying the heterologous production of spinosad through tandem amplification of its biosynthetic gene cluster in Streptomyces coelicolor. MICROBIAL BIOTECHNOLOGY[J]. 2021, [2] Li, Hong, Gao, Wenyan, Cui, Yifan, Pan, Yuanyuan, Liu, Gang. Remarkable enhancement of bleomycin production through precise amplification of its biosynthetic gene cluster in Streptomyces verticillus. SCIENCE CHINA-LIFE SCIENCES. 2021, [3] 钱瑶, 潘园园, 李二伟, 贾慧慧, 魏艳敏, 刘钢. 链霉菌IMS002的分类鉴定及其抗真菌活性物质解析. 微生物学报[J]. 2020, 60(1): 60-68, http://lib.cqvip.com/Qikan/Article/Detail?id=7100982663.
[4] 贾慧慧, 谢心悦, 潘园园, 任争光, 刘钢, 魏艳敏. 芽胞杆菌BJ-6的鉴定及对甜瓜细菌性果斑病的防治. 微生物学报[J]. 2020, 60(5): 982-991, http://lib.cqvip.com/Qikan/Article/Detail?id=7101867094.
[5] 刘钢. 头孢菌素C的生物合成及其调控. 四川师范大学学报. 2020, [6] 刘钢. 头孢菌素C的生物合成及其调控. 四川师范大学学报:自然科学版. 2020, 43(5): 569-579, http://lib.cqvip.com/Qikan/Article/Detail?id=7102794372.
[7] Chen, Chang, Liu, Jiajia, Duan, Chengbao, Pan, Yuanyuan, Liu, Gang. Improvement of the CRISPR-Cas9 mediated gene disruption and large DNA fragment deletion based on a chimeric promoter in Acremonium chrysogenum. FUNGAL GENETICS AND BIOLOGY[J]. 2020, 134: http://dx.doi.org/10.1016/j.fgb.2019.103279.
[8] Zhai, Yanan, Li, Yumei, Zhang, Jinyu, Zhang, Yang, Ren, Fengxia, Zhang, Xiaoling, Liu, Gang, Liu, Xingzhong, Che, Yongsheng. Identification of the gene cluster for bistropolone-humulene meroterpenoid biosynthesis in Phoma sp.. FUNGAL GENETICS AND BIOLOGY[J]. 2019, 129: 7-15, http://dx.doi.org/10.1016/j.fgb.2019.04.004.
[9] 刘钢, 向华. 继往开来的微生物遗传学研究. 微生物学通报[J]. 2019, 221-222, http://lib.cqvip.com/Qikan/Article/Detail?id=87838784504849574850484849.
[10] Zhu, Shuaiming, Ren, Fengxia, Guo, Zhe, Liu, Jianghua, Liu, Xingzhong, Liu, Gang, Che, Yongsheng. Rogersonins A and B, Imidazolone N-Oxide-Incorporating Indole Alkaloids from a verG Disruption Mutant of Clonostachys rogersoniana. JOURNAL OF NATURAL PRODUCTS[J]. 2019, 82(3): 462-468, [11] Wang, Ying, Ren, Jinwei, Li, Honghua, Pan, Yuanyuan, Liu, Xingzhong, Che, Yongsheng, Liu, Gang. The disruption of verM activates the production of gliocladiosin A and B in Clonostachys rogersoniana. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2019, 17(28): 6782-6785, [12] Chen, Chang, He, Jia, Gao, Wenyan, Wei, Yanmin, Liu, Gang. Identification and Characterization of an Autophagy-Related Gene Acatg12 in Acremonium chrysogenum. CURRENT MICROBIOLOGY[J]. 2019, 76(5): 545-551, [13] 段成宝, 刘钢. 利用黑曲霉高效表达外源蛋白策略. 菌物研究. 2019, 17(3): 147-154, http://lib.cqvip.com/Qikan/Article/Detail?id=7101033288.
[14] Pan, Yuanyuan, Liu, Ling, Guan, Feifei, Li, Erwei, Jin, Jin, Li, Jinyang, Che, Yongsheng, Liu, Gang. Characterization of a Prenyltransferase for Iso-A82775C Biosynthesis and Generation of New Congeners of Chloropestolides. ACS CHEMICAL BIOLOGY[J]. 2018, 13(3): 703-711, https://www.webofscience.com/wos/woscc/full-record/WOS:000428003000028.
[15] Liu, Jianghua, Zhai, Yanan, Zhang, Yang, Zhu, Shuaiming, Liu, Gang, Che, Yongsheng. Heterologous Biosynthesis of the Fungal Sesquiterpene Trichodermol in Saccharomyces cerevisiae. FRONTIERS IN MICROBIOLOGY[J]. 2018, 9: https://doaj.org/article/2bcd50ad10654b75b425909f620f3342.
[16] Li, Honghua, Hu, Pengjie, Wang, Ying, Pan, Yuanyuan, Liu, Gang. Enhancing the production of cephalosporin C through modulating the autophagic process of Acremonium chrysogenum. MICROBIAL CELL FACTORIES[J]. 2018, 17(1): https://doaj.org/article/56e1b8fcd2604408bc26e543d36b9aba.
[17] Wang, Ying, Hu, Pengjie, Li, Honghua, Wang, Yanling, Long, Liangkun, Li, Kuan, Zhang, Xiaoling, Pan, Yuanyuan, Liu, Gang. A Myb transcription factor represses conidiation and cephalosporin C production in Acremonium chrysogenum. FUNGAL GENETICS AND BIOLOGY[J]. 2018, 118: 1-9, http://dx.doi.org/10.1016/j.fgb.2018.05.006.
[18] 潘园园, 刘钢. 中国丝状真菌次级代谢分子调控研究进展. 遗传[J]. 2018, 40(10): 874-887, http://lib.cqvip.com/Qikan/Article/Detail?id=7000919287.
[19] He, Xihong, Li, Hong, Pan, Yuanyuan, Wang, Linqi, Tan, Huarong, Liu, Gang. SCO3129, a TetR family regulator, is responsible for osmotic stress in Streptomyces coelicolor. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2018, 3(4): 261-267, http://lib.cqvip.com/Qikan/Article/Detail?id=7103845360.
[20] Liu, Jiajia, Gao, Wenyan, Pan, Yuanyuan, Liu, Gang. Metabolic engineering of Acremonium chrysogenum for improving cephalosporin C production independent of methionine stimulation. MICROBIAL CELL FACTORIES[J]. 2018, 17(1): https://doaj.org/article/9672b3e4d34647fbb1466cb68878b45c.
[21] Zheng, Yanjing, Wang, Xiuna, Zhang, Xiaoling, Li, Wei, Liu, Gang, Wang, Shihua, Yan, Xiufeng, Zou, Huixi, Yin, WenBing. COP9 signalosome subunit PfCsnE regulates secondary metabolism and conidial formation in Pestalotiopsis fici. SCIENCE CHINA-LIFE SCIENCES[J]. 2017, 60(6): 656-664, https://www.webofscience.com/wos/woscc/full-record/WOS:000404775400009.
[22] Guan Feifei, Pan Yuanyuan, Li Jinyang, Liu Gang. A GATA-type transcription factor AcAREB for nitrogen metabolism is involved in regulation of cephalosporin biosynthesis in Acremonium chrysogenum. Science China Life Sciences[J]. 2017, [23] Gang Liu. VerZ, a Zn(II)2Cys6 DNA-binding protein, regulates the biosynthesis of verticillin in Clonostachys rogersoniana.. Microbiology-SGM. 2017, [24] Liu Jiajia, Hao Tianchao, Hu Pengjie, Pan Yuanyuan, Jiang Xuejun, Liu Gang. Functional analysis of the selective autophagy related gene Acatg11 in Acremonium chrysogenum. Fungal Genetics and Biology[J]. 2017, [25] 李红花, 刘钢. CRISPR/Cas9在丝状真菌基因组编辑中的应用. 遗传[J]. 2017, 39(5): 355-367, http://lib.cqvip.com/Qikan/Article/Detail?id=672046785.
[26] 苏豫, 陈依军, 车永胜, 刘钢. 顶头孢霉中己糖激酶编码基因Achka的功能研究. 菌物学报[J]. 2017, 36(3): 323-331, [27] Wang, Ying, Hu, Pengjie, Pan, Yuanyuan, Zhu, Yaxin, Liu, Xingzhong, Che, Yongsheng, Liu, Gang. Identification and characterization of the verticillin biosynthetic gene cluster in Clonostachys rogersoniana. FUNGAL GENETICS AND BIOLOGY[J]. 2017, 103: 25-33, http://dx.doi.org/10.1016/j.fgb.2017.03.007.
[28] Wang Ying, Hu Pengjie, Pan Yuanyuan, Zhu Yaxin, Liu Xingzhong, Che Yongsheng, Liu Gang. Identification and characterization of the verticillin biosynthetic gene cluster in Clonostachys rogersoniana. Fungal Genetics and Biology[J]. 2017, [29] Guo, Zhe, Hao, Tianchao, Wang, Ying, Pan, Yuanyuan, Ren, Fengxia, Liu, Xingzhong, Che, Yongsheng, Liu, Gang. VerZ, a Zn(ll)(2)Cys(6 )DNA-binding protein, regulates the biosynthesis of verticillin in &ITClonostachys rogersoniana&IT. MICROBIOLOGY-SGM[J]. 2017, 163(11): 1654-1663, http://dx.doi.org/10.1099/mic.0.000557.
[30] Guan, Feifei, Pan, Yuanyuan, Li, Jinyang, Liu, Gang. A GATA-type transcription factor AcAREB for nitrogen metabolism is involved in regulation of cephalosporin biosynthesis in Acremonium chrysogenum. SCIENCE CHINA-LIFE SCIENCES[J]. 2017, 60(9): 958-967, https://www.webofscience.com/wos/woscc/full-record/WOS:000409377100004.
[31] Liu, Jiajia, Hao, Tianchao, Hu, Pengjie, Pan, Yuanyuan, Jiang, Xuejun, Liu, Gang. Functional analysis of the selective autophagy related gene Acatg11 in Acremonium chrysogenum. FUNGAL GENETICS AND BIOLOGY[J]. 2017, 107: 67-76, http://dx.doi.org/10.1016/j.fgb.2017.08.006.
[32] 郑艳静, 王秀娜, 章小灵, 李伟, 刘钢, 汪世华, 阎秀峰, 邹慧熙, 尹文兵. COP9信号小体亚基CsnE对无花果拟盘多毛孢生长发育和次级代谢的影响. 中国科学. 生命科学[J]. 2017, 47(7): 750-758, [33] Yu, Lingjun, Gao, Wenyan, Li, Shuxian, Pan, Yuanyuan, Liu, Gang. GntR family regulator SCO6256 is involved in antibiotic production and conditionally regulates the transcription of myo-inositol catabolic genes in Streptomyces coelicolor A3(2). MICROBIOLOGY-SGM[J]. 2016, 162: 537-551, https://www.webofscience.com/wos/woscc/full-record/WOS:000375358500010.
[34] 谢建平, 韩玉波, 刘钢, 白林泉. 2015年中国微生物遗传学研究领域若干重要进展. 遗传[J]. 2016, 38(9): 765-790, http://lib.cqvip.com/Qikan/Article/Detail?id=670061301.
[35] Yu, Lingjun, Pan, Yuanyuan, Liu, Gang. A Regulatory Gene SCO2140 is Involved in Antibiotic Production and Morphological Differentiation of Streptomyces coelicolor A3(2). CURRENT MICROBIOLOGY[J]. 2016, 73(2): 196-201, https://www.webofscience.com/wos/woscc/full-record/WOS:000379181000007.
[36] 刘佳佳, 刘钢. 头孢菌素C生物合成调控研究进展. 微生物学报[J]. 2016, 56(3): 461-470, [37] 杨建霞, 徐欣欣, 潘园园, 郭良栋, 车永胜, 刘钢. 无花果拟盘多毛孢pestheic acid 生物合成中PtaE 参与的苯氧化偶联反应. 菌物学报[J]. 2016, 35(7): 848-856, [38] Yu Lingjun, Pan Yuanyuan, Liu Gang. A Regulatory Gene SCO2140 is Involved in Antibiotic Production and Morphological Differentiation of Streptomyces coelicolor A3(2). Current Microbiology[J]. 2016, [39] Wang, Xiuna, Zhang, Xiaoling, Liu, Ling, Xiang, Meichun, Wang, Wenzhao, Sun, Xiang, Che, Yongsheng, Guo, Liangdong, Liu, Gang, Guo, Liyun, Wang, Chengshu, Yin, WenBing, Stadler, Marc, Zhang, Xinyu, Liu, Xingzhong. Genomic and transcriptomic analysis of the endophytic fungus Pestalotiopsis fici reveals its lifestyle and high potential for synthesis of natural products. BMC GENOMICS[J]. 2015, 16(1): http://dx.doi.org/10.1186/s12864-014-1190-9.
[40] Guo, Zhe, Ren, Fengxia, Che, Yongsheng, Liu, Gang, Liu, Ling. New Bergamotane Sesquiterpenoids from the Plant Endophytic Fungus Paraconiothyrium brasiliense. MOLECULES[J]. 2015, 20(8): 14611-14620, https://doaj.org/article/b0b6d637c1d4410a8b14b85f9fe50873.
[41] Hu, Pengjie, Wang, Ying, Zhou, Jun, Pan, Yuanyuan, Liu, Gang. AcstuA, which encodes an APSES transcription regulator, is involved in conidiation, cephalosporin biosynthesis and cell wall integrity of Acremonium chrysogenum. FUNGAL GENETICS AND BIOLOGY[J]. 2015, 83: 26-40, http://dx.doi.org/10.1016/j.fgb.2015.08.003.
[42] Yu, Lingjun, Li, Shuxian, Gao, Wenyan, Pan, Yuanyuan, Tan, Huarong, Liu, Gang. Regulation of myo-inositol catabolism by a GntR-type repressor SCO6974 in Streptomyces coelicolor. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2015, 99(7): 3141-3153, https://www.webofscience.com/wos/woscc/full-record/WOS:000351547800018.
[43] 谢建平, 岑山, 刘钢. “病原微生物遗传学研究进展专刊”编者寄语. 遗传. 2015, 37(5): 409-411, http://lib.cqvip.com/Qikan/Article/Detail?id=664932142.
[44] 潘园园, 李二伟, 车永胜, 刘钢. 丝状真菌次级代谢产物的研究现状与发展趋势. 菌物学报[J]. 2015, 34(5): 890-899, [45] Xu, Xinxin, Liu, Ling, Zhang, Fan, Wang, Wenzhao, Li, Jinyang, Guo, Liangdong, Che, Yongsheng, Liu, Gang. Identification of the First Diphenyl Ether Gene Cluster for Pestheic Acid Biosynthesis in Plant Endophyte Pestalotiopsis fici. CHEMBIOCHEM[J]. 2014, 15(2): 284-292, https://www.webofscience.com/wos/woscc/full-record/WOS:000329877400014.
[46] Wang, Haoting, Pan, Yuanyuan, Hu, Pengjie, Zhu, Yaxin, Li, Jinyang, Jiang, Xuejun, Liu, Gang. The autophagy-related gene Acatg1 is involved in conidiation and cephalosporin production in Acremonium chrysogenum. FUNGAL GENETICS AND BIOLOGY[J]. 2014, 69: 65-74, http://dx.doi.org/10.1016/j.fgb.2014.06.004.
[47] Liu, Li, Long, LiangKun, An, Yang, Yang, Jing, Xu, Xinxin, Hu, Changhua, Liu, Gang. The thioredoxin reductase-encoding gene ActrxR1 is involved in the cephalosporin C production of Acremonium chrysogenum in methionine-supplemented medium. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2013, 97(6): 2551-2562, https://www.webofscience.com/wos/woscc/full-record/WOS:000315650100025.
[48] 王艳玲, 胡鹏杰, 李二伟, 刘杏忠, 车永胜, 刘钢. 农杆菌介导的粘帚菌遗传转化. 微生物学报[J]. 2013, 53(11): 1233-1239, [49] Liu, Ling, Li, Yan, Li, Li, Cao, Ya, Guo, Liangdong, Liu, Gang, Che, Yongsheng. Spiroketals of Pestalotiopsis fici Provide Evidence for a Biosynthetic Hypothesis Involving Diversified Diels-Alder Reaction Cascades. JOURNAL OF ORGANIC CHEMISTRY[J]. 2013, 78(7): 2992-3000, https://www.webofscience.com/wos/woscc/full-record/WOS:000317327800017.
[50] Long, Liangkun, Wang, Yanling, Yang, Jing, Xu, Xinxin, Liu, Gang. A septation related gene AcsepH in Acremonium chrysogenum is involved in the cellular differentiation and cephalosporin production. FUNGAL GENETICS AND BIOLOGY[J]. 2013, 50: 11-20, http://dx.doi.org/10.1016/j.fgb.2012.11.002.
[51] Ren, Wenkai, Yu, Rui, Liu, Gang, Li, Nengzhang, Peng, Yuanyi, Wu, Miaomiao, Yin, Yulong, Li, Yinghui, Fatufe, Andrew A, Li, Teijun. DNA vaccine encoding the major virulence factors of Shiga toxin type 2e (Stx2e)-expressing Escherichia coli induces protection in mice. VACCINE[J]. 2013, 31(2): 367-372, http://dx.doi.org/10.1016/j.vaccine.2012.10.107.
[52] Pan, Yuanyuan, Lu, Cheng, Dong, Hailing, Yu, Lingjun, Liu, Gang, Tan, Huarong. Disruption of rimP-SC, encoding a ribosome assembly cofactor, markedly enhances the production of several antibiotics in Streptomyces coelicolor. MICROBIAL CELL FACTORIES[J]. 2013, 12(1): 65-65, https://www.webofscience.com/wos/woscc/full-record/WOS:000321921700001.
[53] Li, Jinyang, Pan, Yuanyuan, Liu, Gang. Disruption of the nitrogen regulatory gene AcareA in Acremonium chrysogenum leads to reduction of cephalosporin production and repression of nitrogen metabolism. FUNGAL GENETICS AND BIOLOGY[J]. 2013, 61: 69-79, http://dx.doi.org/10.1016/j.fgb.2013.10.006.
[54] Gang Liu, Chater KF, Govind Chandra, Niu G, Tan H. Molecular Regualtion of antibiotic biosynthesis in Streptomyces.. Microbiology and Molecular Biology Review[J]. 2013, [55] Liu, Gang, Chater, Keith F, Chandra, Govind, Niu, Guoqing, Tan, Huarong. Molecular Regulation of Antibiotic Biosynthesis in Streptomyces. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWSnull. 2013, 77(1): 112-143, https://www.webofscience.com/wos/woscc/full-record/WOS:000319903400004.
[56] Li, Erwei, Zhang, Fan, Niu, Shubin, Liu, Xingzhong, Liu, Gang, Che, Yongsheng. A Spirochroman-3,7 '-isochromene-4,6 '(8 ' H)-dione from the Cordyceps-Colonizing Fungus Fimetariella sp.. ORGANIC LETTERS[J]. 2012, 14(13): 3320-3323, [57] Long, LiangKun, Yang, Jing, An, Yang, Liu, Gang. Disruption of a glutathione reductase encoding gene in Acremonium chrysogenum leads to reduction of its growth, cephalosporin production and antioxidative ability which is recovered by exogenous methionine. FUNGAL GENETICS AND BIOLOGY[J]. 2012, 49(2): 114-122, http://dx.doi.org/10.1016/j.fgb.2011.12.004.
[58] Yang, Jing, Xu, Xinxin, Liu, Gang. Amplification of an MFS Transporter Encoding Gene penT Significantly Stimulates Penicillin Production and Enhances the Sensitivity of Penicillium chrysogenum to Phenylacetic Acid. JOURNAL OF GENETICS AND GENOMICS[J]. 2012, 39(11): 593-602, http://dx.doi.org/10.1016/j.jgg.2012.08.004.
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[61] Xu, Xinxin, Yang, Jing, An, Yang, Pan, Yuanyuan, Liu, Gang. Over-expression of pcvA involved in vesicle-vacuolar fusion affects the conidiation and penicillin production in Penicillium chrysogenum. BIOTECHNOLOGY LETTERS[J]. 2012, 34(3): 519-526, https://www.webofscience.com/wos/woscc/full-record/WOS:000301296300016.
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[63] An, Yang, Dong, Hailing, Liu, Gang. Expression of cefF significantly decreased deacetoxycephalosporin C formation during cephalosporin C production in Acremonium chrysogenum. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY[J]. 2012, 39(2): 269-274, https://www.webofscience.com/wos/woscc/full-record/WOS:000300587300005.
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[65] Pan, Yuanyuan, Wang, Linqi, He, Xihong, Tian, Yuqing, Liu, Gang, Tan, Huarong. SabR enhances nikkomycin production via regulating the transcriptional level of sanG, a pathway-specific regulatory gene in Streptomyces ansochromogenes. BMC MICROBIOLOGY[J]. 2011, 11(1): 164-164, http://www.corc.org.cn/handle/1471x/2374307.
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[70] Yang, Haihua, An, Yang, Wang, Linqi, Zhang, Shuli, Zhang, Yue, Tian, Yuqing, Liu, Gang, Tan, Huarong. Autoregulation of hpdR and its effect on CDA biosynthesis in Streptomyces coelicolor. MICROBIOLOGY-SGM[J]. 2010, 156: 2641-2648, http://124.16.144.217/handle/311023/1804.
[71] Hu, Q, Yang, Lingyuan, Fang, J, Wang, S X, Shu, X G, Deng, Z Y, Liu, Gang, Fan, M Z, Ruan, Z. Estimating an optimal ratio of true digestible Ca:P in corn-rough-soybean meal-based diets for 20-50 kg growing pigs. JOURNAL OF FOOD AGRICULTURE & ENVIRONMENT[J]. 2010, 8(3-4): 556-562, http://www.corc.org.cn/handle/1471x/2415506.
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[73] He, Xihong, Li, Rui, Pan, Yuanyuan, Liu, Gang, Tan, Huarong. SanG, a transcriptional activator, controls nikkomycin biosynthesis through binding to the sanN-sanO intergenic region in Streptomyces ansochromogenes. MICROBIOLOGY-SGM[J]. 2010, 156: 828-837, https://www.webofscience.com/wos/woscc/full-record/WOS:000276189600020.
[74] 杨晶, 安洋, 徐欣欣, 刘钢. 灰黄青霉Pa-pex11基因对青霉素产生的影响. 微生物学报[J]. 2009, 1477-1482, http://lib.cqvip.com/Qikan/Article/Detail?id=32254640.
[75] Pan, Yuanyuan, Liu, Gang, Yang, Haihua, Tian, Yuqing, Tan, Huarong. The pleiotropic regulator AdpA-L directly controls the pathway-specific activator of nikkomycin biosynthesis in Streptomyces ansochromogenes. MOLECULAR MICROBIOLOGY[J]. 2009, 72(3): 710-723, https://www.webofscience.com/wos/woscc/full-record/WOS:000265410500012.
[76] Li, Rui, Xie, Zhouji, Tian, Yuqing, Yang, Haihua, Chen, Wenqing, You, Delin, Liu, Gang, Deng, Zixin, Tan, Huarong. polR, a pathway-specific transcriptional regulatory gene, positively controls polyoxin biosynthesis in Streptomyces cacaoi subsp asoensis. MICROBIOLOGY-SGM[J]. 2009, 155: 1819-1831, https://www.webofscience.com/wos/woscc/full-record/WOS:000267255200007.
[77] Liu, Gang, Zhong, Jin, Ni, Jianqiang, Chen, Meiling, Xiao, Haijie, Huan, Liandong. Characteristics of the bovicin HJ50 gene cluster in Streptococcus bovis HJ50. MICROBIOLOGY-SGM[J]. 2009, 155: 584-593, http://124.16.144.217/handle/311023/1802.
[78] 安洋, 杨晶, 徐欣欣, 刘钢. 一种用于构建红色红曲霉基因组cosmid文库的大片段DNA制备方法. 微生物学报[J]. 2009, 1385-1388, http://lib.cqvip.com/Qikan/Article/Detail?id=31923368.
[79] 梁亮, 盖玉玲, 胡坤, 刘钢. 苏云金芽孢杆菌gerA操纵子在芽孢萌发中的作用. 微生物学报[J]. 2008, 48(3): 281-286, http://lib.cqvip.com/Qikan/Article/Detail?id=26653911.
[80] Liang, Liang, He, Xihong, Liu, Gang, Tan, Huarong. The role of a purine-specific nucleoside hydrolase in spore germination of Bacillus thuringiensis. MICROBIOLOGY-SGM[J]. 2008, 154: 1333-1340, http://124.16.144.217/handle/311023/1784.
[81] Yang, Haihua, Wang, Linqi, Xie, Zhoujie, Tian, Yuqing, Liu, Gang, Tan, Huarong. The tyrosine degradation gene hppD is transcriptionally activated by HpdA and HpdR in Streptomyces coelicolor, while hpdA is negatively autoregulated and repressed repressed by HpdR. MOLECULAR MICROBIOLOGY[J]. 2007, 65(4): 1064-1077, http://www.corc.org.cn/handle/1471x/2380827.
[82] Hu, Kun, Yang, Haihua, Liu, Gang, Tan, Huarong. Cloning and identification of a gene encoding spore cortex-lytic enzyme in Bacillus thuringiensis. CURRENT MICROBIOLOGY[J]. 2007, 54(4): 292-295, http://124.16.144.217/handle/311023/2776.
[83] Ling, Hongbo, Wang, Guojun, Tian, Yuqing, Liu, Gang, Tan, Huarong. SanM catalyzes the formation of 4-pyridyl-2-oxo-4-hydroxyisovalerate in nikkomycin biosynthesis by interacting with SanN. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2007, 361(1): 196-201, http://124.16.144.217/handle/311023/2444.
[84] Xie, Zhoujie, Li, Wenli, Tian, Yuqing, Liu, Gang, Tan, Huarong. Identification and characterization of sawC, a whiA-like gene, essential for sporulation in Streptomyces ansochromogenes. ARCHIVES OF MICROBIOLOGY[J]. 2007, 188(6): 575-582, http://124.16.144.217/handle/311023/2760.
[85] Yan, Xiaohua, Gai, Yuling, Liang, Liang, Liu, Gang, Tan, Huarong. A gene encoding alanine racemase is involved in spore germination in Bacillus thuringiensis. ARCHIVES OF MICROBIOLOGY[J]. 2007, 187(5): 371-378, http://124.16.144.217/handle/311023/2756.
[86] 严晓华, 刘钢, 谭华荣. 苏云金芽孢杆菌芽孢萌发相关基因gerM的克隆及功能研究. 微生物学报[J]. 2007, 47(1): 17-21, http://lib.cqvip.com/Qikan/Article/Detail?id=23766144.
[87] Hu, Kun, Yang, Haihua, Liu, Gang, Tan, Huarong. Identification and characterization of a polysaccharide deacetylase gene from Bacillus thuringiensis. CANADIAN JOURNAL OF MICROBIOLOGY[J]. 2006, 52(10): 935-941, http://124.16.144.217/handle/311023/2478.
[88] Gai, Yuling, Liu, Gang, Tan, Huarong. Identification and characterization of a germination operon from Bacillus thuringiensis. ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY[J]. 2006, 89(2): 251-259, http://dx.doi.org/10.1007/s10482-005-9026-x.
[89] Niu, Guoqing, Liu, Gang, Tian, Yuqing, Tan, Huarong. SanJ, an ATP-dependent picolinate-CoA ligase, catalyzes the conversion of picolinate to picolinate-CoA during nikkomycin biosynthesis in Streptomyces ansochromogenes. METABOLIC ENGINEERING[J]. 2006, 8(3): 183-195, http://www.corc.org.cn/handle/1471x/2379921.
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发表著作
(1) 微生物遗传与分子生物学, 科学出版社, 2019-08, 第 3 作者

科研活动

   
科研项目
( 1 ) 依赖于AcPpm1的甲硫氨酸参与的头孢菌素生物合成的分子调控, 主持, 国家级, 2017-01--2020-12
( 2 ) 中科院合成生物学元件库的建设, 主持, 部委级, 2018-08--2020-07
( 3 ) 牛栏山白酒酿造过程中宏转录组学与代谢组学关联研究, 主持, 院级, 2019-03--2022-02
( 4 ) 28) 利用真菌表达重组人源溶菌酶的技术开发, 主持, 院级, 2019-10--2020-04
参与会议
(1)头孢菌素生物合成的分子调控   2015年中国微生物学会学术年会   2015-10-23
(2)头孢菌素生物合成中的自噬研究   2015中国遗传学大会   2015-08-14

指导学生

已指导学生

盖玉玲  硕士研究生  071007-遗传学  

梁亮  硕士研究生  071007-遗传学  

严晓华  硕士研究生  071007-遗传学  

安洋  硕士研究生  071007-遗传学  

杨晶  硕士研究生  071007-遗传学  

何希宏  博士研究生  071007-遗传学  

杨晶  博士研究生  071007-遗传学  

徐欣欣  博士研究生  071007-遗传学  

李金阳  硕士研究生  071007-遗传学  

王艳玲  硕士研究生  430139-生物工程  

王颢婷  硕士研究生  071007-遗传学  

李淑贤  硕士研究生  085238-生物工程  

俞灵军  博士研究生  071007-遗传学  

杨建霞  硕士研究生  071007-遗传学  

关菲菲  博士研究生  071007-遗传学  

郝田超  硕士研究生  071007-遗传学  

王瑛  博士研究生  071007-遗传学  

郭哲  博士研究生  071007-遗传学  

钱瑶  硕士研究生  071007-遗传学  

刘佳佳  博士研究生  071007-遗传学  

现指导学生

李红花  博士研究生  071007-遗传学  

段成宝  硕士研究生  085238-生物工程  

陈昶  博士研究生  071007-遗传学  

冯璐璐  硕士研究生  071007-遗传学  

李红  博士研究生  071007-遗传学  

武梦  硕士研究生  071007-遗传学  

窦凯琦  博士研究生  071007-遗传学