梁璟  女  博导  中国科学院心理研究所
电子邮件: liangj@psych.ac.cn
通信地址: 北京朝阳区林萃路16号心理所
邮政编码: 100101

研究方向

情绪记忆的神经环路
认知灵活性的神经机制及临床转化

招生信息

招收博士研究生和硕士研究生。

招生专业
0402Z1-健康心理学
0402Z2-认知神经科学
071006-神经生物学
招生方向
情绪记忆的神经环路
认知灵活性的神经机制及临床转化

教育背景

2002-09--2007-06   北京大学   博士
1997-09--2002-06   山西医科大学   学士
学历
研究生学历

学位
博士学位

工作经历

获得博士学位后,一直从事科研工作。

工作简历
2022-08~现在, 中国科学院心理研究所, 研究员
2011-11~2013-11,美国斯坦福大学, 访问副教授
2011-04~2022-07,中国科学院心理研究所, 副研究员
2007-07~2011-03,中国科学院心理研究所, 助理研究员
社会兼职
2022-02-22-今,中国心理学会生理心理学专业学术委员会, 委员
2021-08-18-今,北京神经科学学会青年委员会, 委员兼秘书
2018-12-01-今,中国毒理学会药物依赖性毒理学专业委员会, 委员
2017-05-10-今,中国药物滥用防治协会青年委员会, 委员

教授课程

临床神经科学
功能神经解剖
入学教育与交流
神经传递、神经心理学、神经病学和神经药理学

专利与奖励

   
奖励信息
(1) 中华医学科技奖青年科技奖, 国家级, 2021
(2) 北京市科学技术奖, 三等奖, 市地级, 2016
(3) 中华医学科技奖, 三等奖, 国家级, 2013
(4) 北京大学科技创新奖, 一等奖, 研究所(学校), 2006
(5) 北京大学光华奖, 一等奖, 研究所(学校), 2004
(6) 北京大学神经科学研究所优秀奖, 一等奖, 专项, 2004

出版信息

   
发表论文
(1) The role of hippocampus in memory reactivation: an implication for a therapeutic target against opioid use disorder, Current Addiction Reports, 2022, 通讯作者
(2) Embryonic opioid exposure impairs inhibitory transmission of striatum in day-old chicks, Dev Psychobiol, 2022, 通讯作者
(3) Corticotropin-releasing factor receptor 1 in infralimbic cortex modulates social stress-altered decision-making, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2022, 通讯作者
(4) Endocannabinoids and addiction memory: Relevance to methamphetamine/morphine abuse, World J Biol Psychiatry ., 2022, 通讯作者
(5) 下丘脑黑皮质素及中脑多巴胺系统对奖赏行为的调控, 生物化学与生物物理进展, 2021, 通讯作者
(6) Hypothalamic Melanocortin and Mesencephalic Dopamine Systems Regulate Reward-related Behaviors in Food Intake and Drug Use, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2021, 第 6 作者
(7) Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor-mediated upregulation of Ca(v)1.2, ADDICTION BIOLOGY, 2021, 第 6 作者
(8) Double dissociation of inhibitory effects between the hippocampal TET1 and TET3 in the acquisition of morphine self-administration in rats, ADDICTION BIOLOGY, 2020, 第 6 作者
(9) DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats, ADDICTION BIOLOGY, 2020, 第 7 作者
(10) Parvalbumin interneuron in the ventral hippocampus functions as a discriminator in social memory, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 第 5 作者
(11) Medium spiny neurons of the anterior dorsomedial striatum mediate reversal learning in a cell-type-dependent manner, Brain Struct Funct, 2019, 通讯作者
(12) Alterations in brain activation in response to prolonged morphine withdrawal-induced behavioral inflexibility in rats, PSYCHOPHARMACOLOGY, 2017, 第 9 作者
(13) Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility, BEHAVIOURAL BRAIN RESEARCH, 2017, 第 6 作者
(14) Functional inactivation of dorsal medial striatum alters behavioral flexibility and recognition process in mice, Physiology & Behavior, 2017, 
(15) Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats, FRONTIERS IN MOLECULAR NEUROSCIENCE, 2017, 第11作者
(16) Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments, MOLECULAR PSYCHIATRY, 2015, 第 1 作者
(17) Post-training corticosterone inhibits the return of fear evoked by platform stress and a subthreshold conditioning procedure in Sprague–Dawley rats, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2015, 第 5 作者
(18) N-methyl-D-aspartate receptor-mediated glutamate transmission in nucleus accumbens plays a more important role than that in dorsal striatum in cognitive flexibility, FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2014, 第 6 作者
(19) Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine, EUROPEAN JOURNAL OF PHARMACOLOGY, 2013, 第 2 作者
(20) Dynamic changes of tyrosine hydroxylase and dopamine concentration in the VTA-NAc projection during the morphine-CPP expression in rats, Neurochemical Research, 2012, 第 1 作者
(21) Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats, NEUROCHEMICAL RESEARCH, 2012, 第 1 作者
(22) Differential patterns of neuronal activation in rostral versus caudal ventral tegmental area involved in behavioral sensitization induced by an escalating-dose morphine administration paradigm, EUROPEAN JOURNAL OF PHARMACOLOGY, 2012, 第 3 作者
(23) Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: role of enkephalin in the nucleus accumbens., Neuropharmacology, 2011, 第 1 作者
(24) The expression of morphine-induced behavioral sensitization depends more on treatment regimen and environmental novelty than on conditioned drug effects., Chin Sci Bull., 2011, 第 1 作者
(25) Gene expression of conditioned locomotion and context-specific locomotor sensitization controlled by morphine-associated environment, BEHAVIOURAL BRAIN RESEARCH, 2011, 第 1 作者
(26) Roles of BDNF, dopamine D 3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization, EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2011, 第 1 作者
(27) Coexistence of Anhedonia and anxiety-independent increased novelty-seeking behavior in the chronic mild stress model of depression, BEHAVIOURAL PROCESSES, 2010, 第 3 作者
(28) Effect of prolonged traumatic context exposure on conditioned fear response., Chin J Behav Med and Brain Sci., 2009, 第 1 作者
(29) Electroacupuncture of 2 Hz has a Rewarding Effect: Evidence from a Conditioned Place Preference Study in Rats., Evid Based Complement Alternat Med., 2008, 第 1 作者
(30) The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats., Peptides, 2007, 第 1 作者
(31) Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats, EXPERIMENTAL NEUROLOGY, 2005, 

科研活动

   
科研项目
( 1 ) 纹状体神经元树突嵴结构及功能重塑在成瘾性用药导致的认知弹性损伤中的作用, 负责人, 国家任务, 2013-01--2016-12
( 2 ) 精神活性物质成瘾记忆的形成和消除, 参与, 国家任务, 2015-01--2019-08
( 3 ) 自闭症症状相关的“皮层-基底神经节-丘脑-皮层”环路功能失常, 负责人, 国家任务, 2016-01--2019-12
( 4 ) 内侧前额叶皮层-伏隔核神经环路对于认知灵活性的调控作用, 负责人, 地方任务, 2016-01--2018-12
( 5 ) 海马参与孤独症社交认知障碍的病理机制及矫正方式探索, 负责人, 地方任务, 2020-01--2022-12
( 6 ) 应激对刺激-反应/习惯记忆的影响与干预措施研究, 负责人, 国家任务, 2017-07--2019-01
( 7 ) 伏隔核AMPA受体的突触可塑性在成瘾大鼠戒断后觅药动机行为中的作用, 负责人, 国家任务, 2010-01--2012-12
( 8 ) 蓝斑-齿状回神经通路在情景匹配程度依赖的阿片戒断记忆活化中的调 控作用, 负责人, 国家任务, 2021-01--2024-12
( 9 ) 注意的神经编码与调控机制(子课题), 负责人, 国家任务, 2021-12--2026-11
参与会议
(1)Parvalbumin Interneuron in the Ventral Hippocampus Functions as a Discriminator in Social Memory   2019-03-28
(2)调控行为策略转换的纹状体-苍白球环路机制   第十五届全国药物依赖性学术会议暨国际精神疾病研讨会   2018-11-29
(3)内侧前额叶皮层神经元的长期高活性状态与认知损伤的关系研究   第十四届全国药物依赖性学术会议暨国际精神疾病研讨会   2016-11-30
(4)The pattern of behavioral inflexibility during morphine withdrawal and its potential mechanisms   2016-02-19