情绪记忆的神经环路
认知灵活性的神经机制及临床转化

招收博士研究生和硕士研究生。

0402Z1-健康心理学
0402Z2-认知神经科学
071006-神经生物学

情绪记忆的神经环路
认知灵活性的神经机制及临床转化

2002-09--2007-06   北京大学   博士
1997-09--2002-06   山西医科大学   学士

研究生学历

博士学位

获得博士学位后，一直从事科研工作。

2022-08~现在, 中国科学院心理研究所, 研究员
2011-11~2013-11,美国斯坦福大学, 访问副教授
2011-04~2022-07,中国科学院心理研究所, 副研究员
2007-07~2011-03,中国科学院心理研究所, 助理研究员

2022-02-22-今,中国心理学会生理心理学专业学术委员会, 委员
2021-08-18-今,北京神经科学学会青年委员会, 委员兼秘书
2018-12-01-今,中国毒理学会药物依赖性毒理学专业委员会, 委员
2017-05-10-今,中国药物滥用防治协会青年委员会, 委员

临床神经科学
功能神经解剖
入学教育与交流
神经传递、神经心理学、神经病学和神经药理学

   

（1） 中华医学科技奖青年科技奖, 国家级, 2021
（2） 北京市科学技术奖, 三等奖, 市地级, 2016
（3） 中华医学科技奖, 三等奖, 国家级, 2013
（4） 北京大学科技创新奖, 一等奖, 研究所（学校）, 2006
（5） 北京大学光华奖, 一等奖, 研究所（学校）, 2004
（6） 北京大学神经科学研究所优秀奖, 一等奖, 专项, 2004

[1] 徐星, 梁璟, 张琨, 沈芳, 黄景新. 一种啮齿类动物多模态注意测试系统. CN: CN116392124A, 2023-07-07.
[2] 张建军, 薛冰, 马寅燕, 梁璟. 一种啮齿动物饲养与行为学实验装置. CN: CN217407375U, 2022-09-13.
[3] 张建军, 马寅燕, 薛冰, 梁璟. 一种可拼装组合式小动物行为实验箱. CN: CN217407376U, 2022-09-13.
[4] 张建军, 薛冰, 马寅燕, 梁璟. 一种啮齿动物饲养与行为学实验装置及建立慢性社会比较应激模型的方法. CN: CN114902967A, 2022-08-16.

   

[1] Progress in Neurobiology. 2024,   通讯作者  
[2] Neuropsychopharmacology. 2023,   通讯作者  
[3] Xue, Bing, Ma, YinYan, Zhu, JieYing, Mu, Yan, Li, YongHui, Shen, Fang, Liang, Jing, Zhang, JianJun. Chronic social comparison elicits depression- and anxiety-like behaviors and alterations in brain-derived neurotrophic factor expression in male rats. ANIMAL COGNITION[J]. 2023, 第 7 作者26(5): 1505-1519, http://dx.doi.org/10.1007/s10071-023-01798-7.
[4] Ying Duan, Lingtong Jin, Wenjie Du, Yiming Meng, Jing Liang, Jianjun Zhang, Nan Sui, Fang Shen. Distinctive roles of L-type calcium channels subtypes within the dorsal hippocampus in formation of morphine withdrawal-induced aversion in rats. PROGRESS IN NEUROPSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2023, 第 5 作者127: http://dx.doi.org/10.1016/j.pnpbp.2023.110818.
[5] Dai, Zhonghua, Liu, Ying, Nie, Lina, Chen, Weiqi, Xu, Xing, Li, Yonghui, Zhang, Jianjun, Shen, Fang, Sui, Nan, Liang, Jing. Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction. NEUROPSYCHOPHARMACOLOGY[J]. 2023, 第 10 作者  通讯作者  48(2): 327-340, 
[6] Alizamini, Mirmohammadali Mirramezani, Fattahi, Mojdeh, Sayehmiri, Fatemeh, Haghparast, Abbas, Liang, Jing. Regulatory Role of PFC Corticotropin-Releasing Factor System in Stress-Associated Depression Disorders: A Systematic Review. CELLULAR AND MOLECULAR NEUROBIOLOGY. 2023, 第 5 作者  通讯作者  43(5): 1785-1797, http://dx.doi.org/10.1007/s10571-022-01289-2.
[7] 代中华, 徐星, 陈卫奇, 聂莉娜, 刘颖, 隋南, 梁璟. The role of hippocampus in memory reactivation: an implication for a therapeutic target against opioid use disorder. Current Addiction Reports[J]. 2022, 第 7 作者  通讯作者  
[8] Ying Duan, Lingtong Jin, Wenjie Du, Shubo Jin, Yiming Meng, Yonghui Li, Jianjun Zhang, Jing Liang, Nan Sui, Fang Shen. Alterations of Dopamine Receptors and the Adaptive Changes of L-Type Calcium Channel Subtypes Regulate Cocaine-Seeking Habit in Tree Shrew. LIFE[J]. 2022, 第 8 作者12(984): https://doaj.org/article/7eae3a67adb14226a5814255b99ca4dc.
[9] Alizamini, Mirmohammadali Mirramezani, Li, Yonghui, Zhang, JianJun, Liang, Jing, Haghparast, Abbas. Endocannabinoids and addiction memory: Relevance to methamphetamine/morphine abuse. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY. 2022, 第 4 作者  通讯作者  23(10): 743-763, http://dx.doi.org/10.1080/15622975.2022.2039408.
[10] 薛冰, 马寅燕, 梁璟, 李勇辉, 张建军. 甘丙肽对抑郁症状的调控作用及其机制的研究进展. 生物化学与生物物理进展[J]. 2022, 第 3 作者49(1): 113-125, http://www.pibb.ac.cn/pibbcn/ch/reader/create_pdf.aspx?file_no=20210335&flag=1&journal_id=pibbcn.
[11] Mirmohammadali Mirramezani Alizamini, Li, Yonghui, Jian-Jun Zhang, 梁璟, Abbas Haghparast. Endocannabinoids and addiction memory: Relevance to methamphetamine/morphine abuse. World J Biol Psychiatry .[J]. 2022, 第 4 作者  通讯作者  
[12] Mirmohammadali Mirramezani Alizamini, 陈星, 聂莉娜, 代中华, 刘颖, Abbas Haghparast, 张建军, 沈芳, 隋南, 梁璟. Corticotropin-releasing factor receptor 1 in infralimbic cortex modulates social stress-altered decision-making. Progress in Neuro-Psychopharmacology & Biological Psychiatry[J]. 2022, 第 10 作者  通讯作者  
[13] Chao Wu, Wei Zheng, Xiaohua Jia, Yonghui Li, Fang Shen, Abbas Haghparast, Jing Liang, Nan Sui, 张建军. Adolescent chronic unpredictable stress causes a bias in goal-directed behavior and distinctively changes the expression of NMDA and dopamine receptors in the dorsomedial and dorsolateral striatum in male rats. Developmental Psychobiology[J]. 2022, 第 7 作者
[14] Shang, Wen, Dai, Zhonghua, Zhang, Jianjun, Shen, Fang, Sui, Nan, Liang, Jing. Embryonic opioid exposure impairs inhibitory transmission of striatum in day-old chicks. DEVELOPMENTAL PSYCHOBIOLOGY[J]. 2022, 第 6 作者  通讯作者  64(4): http://dx.doi.org/10.1002/dev.22273.
[15] Du, Wenjie, Liu, Ying, Meng, Yiming, Yan, Yimin, Jin, Lingtong, Zhang, Jianjun, Liang, Jing, Li, Yonghui, Shen, Fang. A Translation from Goal-Directed to Habitual Control: the Striatum in Drug Addiction. CURRENT ADDICTION REPORTS[J]. 2021, 第 7 作者8(4): 530-537, http://dx.doi.org/10.1007/s40429-021-00392-6.
[16] 薛冰, 马寅燕, 梁璟, 李勇辉, 张建军. 甘丙肽对抑郁症状的调控作用及其机制的研究进展. 生物化学与生物物理进展[J]. 2021, 第 3 作者15, 
[17] Liu Ying, Liu Chao, Lin QingHua, Zhang JianJun, Du WenJie, Liang Jing, Sui Nan. Hypothalamic Melanocortin and Mesencephalic Dopamine Systems Regulate Reward-related Behaviors in Food Intake and Drug Use. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2021, 第 6 作者48(5): 541-549, http://dx.doi.org/10.16476/j.pibb.2020.0281.
[18] Jiang, FengZe, Zheng, Wei, Wu, Chao, Li, Yonghui, Shen, Fang, Liang, Jing, Li, Ming, Zhang, JianJun, Sui, Nan. Double dissociation of inhibitory effects between the hippocampal TET1 and TET3 in the acquisition of morphine self-administration in rats. ADDICTION BIOLOGY[J]. 2021, 第 6 作者26(1): http://dx.doi.org/10.1111/adb.12875.
[19] Duan, Ying, Meng, Yiming, Du, Wenjie, Li, Ming, Zhang, Jianjun, Liang, Jing, Li, Yonghui, Sui, Nan, Shen, Fang. Increased cocaine motivation in tree shrews is modulated by striatal dopamine D1 receptor-mediated upregulation of Ca(v)1.2. ADDICTION BIOLOGY[J]. 2021, 第 6 作者26(6): http://dx.doi.org/10.1111/adb.13053.
[20] Zhang, JianJun, Jiang, FengZe, Zheng, Wei, Duan, Ying, Jin, ShuBo, Shen, Fang, Liang, Jing, Li, Ming, Sui, Nan. DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats. ADDICTION BIOLOGY[J]. 2020, 第 7 作者25(2): 12, 
[21] Proc Natl Acad Sci U S A.. 2019,   通讯作者  
[22] Deng, Xiaofei, Gu, Lijia, Sui, Nan, Guo, Jianyou, Liang, Jing. Parvalbumin interneuron in the ventral hippocampus functions as a discriminator in social memory. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 第 5 作者116(33): 16583-16592, http://dx.doi.org/10.1073/pnas.1819133116.
[23] Wang, Xingyue, Qiao, Yanhua, Dai, Zhonghua, Sui, Nan, Shen, Fang, Zhang, Jianjun, Liang, Jing. Medium spiny neurons of the anterior dorsomedial striatum mediate reversal learning in a cell-type-dependent manner. BRAIN STRUCT FUNCT[J]. 2019, 第 7 作者  通讯作者  224(1): 419-434, http://dx.doi.org/10.1007/s00429-018-1780-4.
[24] Piao, Chengji, Liu, Tiane, Ma, Lian, Ding, Xuekun, Wang, Xingyue, Chen, Xing, Duan, Ying, Sui, Nan, Liang, Jing. Alterations in brain activation in response to prolonged morphine withdrawal-induced behavioral inflexibility in rats. PSYCHOPHARMACOLOGY[J]. 2017, 第 9 作者234(19): 2941-2953, http://dx.doi.org/10.1007/s00213-017-4689-3.
[25] Qiao, Yanhua, Wang, Xingyue, Ma, Lian, Li, Shengguang, Liang, Jing. Functional inactivation of dorsal medial striatum afters behavioral flexibility and recognition process in mice. PHYSIOLOGY & BEHAVIOR[J]. 2017, 第 5 作者179: 467-477, http://dx.doi.org/10.1016/j.physbeh.2017.07.026.
[26] Piao, Chengji, Deng, Xiaofei, Wang, Xingyue, Yuan, Yiran, Liu, Zhengkui, Liang, Jing. Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility. BEHAVIOURAL BRAIN RESEARCH[J]. 2017, 第 6 作者317: 16-26, http://dx.doi.org/10.1016/j.bbr.2016.09.017.
[27] Qiao Yanhua, Wang Xingyue, Ma Lian, Li Shengguang, Liang Jing. Functional inactivation of dorsal medial striatum alters behavioral flexibility and recognition process in mice. PHYSIOLOGY & BEHAVIOR[J]. 2017, 第 5 作者179: 467-477, http://dx.doi.org/10.1016/j.physbeh.2017.07.026.
[28] Tian, Yonglu, Yang, Chaojuan, Shang, Shujiang, Cai, Yijun, Deng, Xiaofei, Zhang, Jian, Shao, Feng, Zhu, Desheng, Liu, Yunbo, Chen, Guiquan, Liang, Jing, Sun, Qiang, Qiu, Zilong, Zhang, Chen. Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats. FRONTIERSINMOLECULARNEUROSCIENCE[J]. 2017, 第 11 作者10: http://dx.doi.org/10.3389/fnmol.2017.00269.
[29] Liang, Jing, Xu, Wei, Hsu, Yutien, Yee, X Ada, Chen, Lu, Suedhof, C Thomas. Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments. MOLECULAR PSYCHIATRY[J]. 2015, 第 1 作者20(7): 850-859, http://dx.doi.org/10.1038/mp.2015.31.
[30] Xing, Xiaoli, Wang, Hongbo, Zhang, Lili, Bai, Yunjing, Liang, Jing, Liu, Zhengkui, Zheng, Xigeng. Post-training corticosterone inhibits the return of fear evoked by platform stress and a subthreshold conditioning procedure in Sprague-Dawley rats. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR[J]. 2015, 第 5 作者133: 43-50, http://dx.doi.org/10.1016/j.pbb.2015.03.013.
[31] Wang, Hongbo, Xing, Xiaoli, Liang, Jing, Bai, Yunjing, Lui, Zhengkui, Zheng, Xigeng. High-dose corticosterone after fear conditioning selectively suppresses fear renewal by reducing anxiety-like response. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR[J]. 2014, 第 3 作者124: 188-195, http://dx.doi.org/10.1016/j.pbb.2014.06.003.
[32] Ding, Xuekun, Qiao, Yanhua, Piao, Chengji, Zheng, Xigeng, Liu, Zhengkui, Liang, Jing. N-methyl-D-aspartate receptor-mediated glutamate transmission in nucleus accumbens plays a more important role than that in dorsal striatum in cognitive flexibility. FRONTIERS IN BEHAVIORAL NEUROSCIENCE[J]. 2014, 第 6 作者8: http://dx.doi.org/10.3389/fnbeh.2014.00304.
[33] Ding, Xuekun, Liang, Jing, Zheng, Xigeng, Bai, Yunjing, Liu, Zhengkui, Li, Yingying, Xing, Xiaoli. Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2013, 第 2 作者702(1-3): 294-301, http://dx.doi.org/10.1016/j.ejphar.2013.01.051.
[34] 梁璟. Dynamic changes of tyrosine hydroxylase and dopamine concentration in the VTA-NAc projection during the morphine-CPP expression in rats. Neurochemical Research. 2012, 第 1 作者
[35] 白云静, 彭永华, 梁璟, 郑希耕. VTA喙部神经元激活与递增大剂量吗啡诱导的行为敏感化有关. 首届心理健康学术年会. 2012, 第 3 作者http://www.chinair.org.cn/handle/1471x/1667267.
[36] Liang, Jing, Ma, Sisi, Li, Yijing, Ping, Xingjie, Hu, Ling, Cui, Cailian. Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats. NEUROCHEMICAL RESEARCH[J]. 2012, 第 1 作者37(7): 1482-1489, http://www.irgrid.ac.cn/handle/1471x/951953.
[37] Bai, Yunjing, Peng, Yonghua, Liang, Jing, Zheng, Xigeng. Differential patterns of neuronal activation in rostral versus caudal ventral tegmental area involved in behavioral sensitization induced by an escalating-dose morphine administration paradigm. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2012, 第 3 作者689(1-3): 118-124, http://dx.doi.org/10.1016/j.ejphar.2012.05.011.
[38] 梁璟. Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: role of enkephalin in the nucleus accumbens.. Neuropharmacology. 2011, 第 1 作者
[39] 梁璟. The expression of morphine-induced behavioral sensitization depends more on treatment regimen and environmental novelty than on conditioned drug effects.. Chin Sci Bull.. 2011, 第 1 作者
[40] 彭永华, 梁璟, 白云静, 郑希耕. 强迫性觅药用药行为动物模型及其神经机制. 中国药物依赖性杂志[J]. 2011, 第 2 作者20(3): 161-164, http://lib.cqvip.com/Qikan/Article/Detail?id=38186070.
[41] 郑希耕, 白云静, 彭永华, 梁璟. 吗啡诱发的大鼠强迫性觅药动机及中脑神经元活动性改变. 中华行为医学与脑科学杂志[J]. 2011, 第 4 作者20(8): 677-680, http://lib.cqvip.com/Qikan/Article/Detail?id=39069764.
[42] Liang, Jing, Chen, JiHuan, Chen, XiaoHong, Peng, YongHua, Zheng, Xigeng. Gene expression of conditioned locomotion and context-specific locomotor sensitization controlled by morphine-associated environment. BEHAVIOURAL BRAIN RESEARCH[J]. 2011, 第 1 作者216(1): 321-331, http://dx.doi.org/10.1016/j.bbr.2010.08.012.
[43] Liang, Jing, Zheng, Xigeng, Chen, Jihuan, Li, Yingying, Xing, Xiaoli, Bai, Yunjing, Li, Yingcong. Roles of BDNF, dopamine D-3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization. EUROPEAN NEUROPSYCHOPHARMACOLOGY[J]. 2011, 第 1 作者21(11): 825-834, http://dx.doi.org/10.1016/j.euroneuro.2010.12.006.
[44] LIANG Jing, PENG YongHua, GE XiaoXiang, ZHENG XiGeng. The expression of morphine-induced behavioral sensitization depends more on treatment regimen and environmental novelty than on conditioned drug effects. 中国科学通报：英文版[J]. 2010, 第 1 作者2016-2020, http://lib.cqvip.com/Qikan/Article/Detail?id=34527383.
[45] Liang Jing, Peng YongHua, Ge XiaoXiang, Zheng XiGeng. The expression of morphine-induced behavioral sensitization depends more on treatment regimen and environmental novelty than on conditioned drug effects. CHINESE SCIENCE BULLETIN[J]. 2010, 第 1 作者55(19): 2016-2020, http://dx.doi.org/10.1007/s11434-010-3206-4.
[46] Li, Youhong, Zheng, Xigeng, Liang, Jing, Peng, Yuonghua. Coexistence of Anhedonia and anxiety-independent increased novelty-seeking behavior in the chronic mild stress model of depression. BEHAVIOURAL PROCESSES[J]. 2010, 第 3 作者83(3): 331-339, http://dx.doi.org/10.1016/j.beproc.2010.01.020.
[47] 安献丽, 梁璟, 郑伦, 李幼虹, 王文忠, 郑希耕. 延长创伤环境暴露时间对条件性恐惧表达的影响. 中华行为医学与脑科学杂志[J]. 2009, 第 2 作者775-778, http://lib.cqvip.com/Qikan/Article/Detail?id=31593560.
[48] 梁璟. Effect of prolonged traumatic context exposure on conditioned fear response.. Chin J Behav Med and Brain Sci.. 2009, 第 1 作者
[49] 梁璟. Electroacupuncture of 2 Hz has a Rewarding Effect: Evidence from a Conditioned Place Preference Study in Rats.. Evid Based Complement Alternat Med.. 2008, 第 1 作者
[50] 梁璟. The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats.. Peptides. 2007, 第 1 作者
[51] Chen, JH, Liang, J, Wang, GB, Han, JS, Cui, CL. Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats. EXPERIMENTAL NEUROLOGY[J]. 2005, 194(2): 550-556, http://dx.doi.org/10.1016/j.expneurol.2005.04.001.

   

（ 1 ） 纹状体神经元树突嵴结构及功能重塑在成瘾性用药导致的认知弹性损伤中的作用, 负责人, 国家任务, 2013-01--2016-12
（ 2 ） 精神活性物质成瘾记忆的形成和消除, 参与, 国家任务, 2015-01--2019-08
（ 3 ） 自闭症症状相关的“皮层-基底神经节-丘脑-皮层”环路功能失常, 负责人, 国家任务, 2016-01--2019-12
（ 4 ） 内侧前额叶皮层-伏隔核神经环路对于认知灵活性的调控作用, 负责人, 地方任务, 2016-01--2018-12
（ 5 ） 海马参与孤独症社交认知障碍的病理机制及矫正方式探索, 负责人, 地方任务, 2020-01--2022-12
（ 6 ） 应激对刺激-反应/习惯记忆的影响与干预措施研究, 负责人, 国家任务, 2017-07--2019-01
（ 7 ） 伏隔核AMPA受体的突触可塑性在成瘾大鼠戒断后觅药动机行为中的作用, 负责人, 国家任务, 2010-01--2012-12
（ 8 ） 蓝斑-齿状回神经通路在情景匹配程度依赖的阿片戒断记忆活化中的调 控作用, 负责人, 国家任务, 2021-01--2024-12
（ 9 ） 注意的神经编码与调控机制（子课题）, 负责人, 国家任务, 2021-12--2026-11

（1）Parvalbumin Interneuron in the Ventral Hippocampus Functions as a Discriminator in Social Memory   2019-03-28
（2）调控行为策略转换的纹状体-苍白球环路机制   第十五届全国药物依赖性学术会议暨国际精神疾病研讨会   2018-11-29
（3）内侧前额叶皮层神经元的长期高活性状态与认知损伤的关系研究   第十四届全国药物依赖性学术会议暨国际精神疾病研讨会   2016-11-30
（4）The pattern of behavioral inflexibility during morphine withdrawal and its potential mechanisms   2016-02-19