（一）基础研究
　　1、炎症小体活化及调控的分子机理
　　NLRP3炎症小体能被种类众多而相关性不大的刺激物激活，包括铝盐、硅颗粒、流感病毒、ATP等，这提示其上游有众多的调控分子。我们将通过多种技术手段寻找调控炎症小体活化的新分子，并对这些分子的作用机理进行深入研究。
　　2、炎症小体在自身免疫性疾病中的作用机理
　　已有研究发现NLRP3炎症小体跟系统性红斑狼疮和结肠炎等疾病的发生有关。本实验室将深入研究NLRP3在这两种疾病中发挥作用的分子和细胞机制，以及天然免疫系统影响获得性免疫反应的机理。
　　3、炎症小体在抗感染中的作用机理
　　作为天然免疫系统的重要组成部分，炎症小体在对抗病原微生物感染过程中发挥重要作用。已有研究发现NLRP3炎症小体在抗流感病毒、腺病毒、白色念珠菌等病原体感染中作用非常关键。我们结合本所病原微生物研究的优势，探索NLRP3在抗重要病原微生物感染过程中的功能及相关机制。

（二）应用研究
　　1、炎症小体的药理调控
　　NLRP3炎症小体参与众多的生理病理过程，因此寻找合适的药物调控炎症小体具有重要的治疗价值。我们将探索多种药物对NLRP3的调控作用，并通过适当的改造以开发对炎症小体的干预策略。
　　2、基于NLR信号的疫苗佐剂开发

071005-微生物学
085238-生物工程

天然免疫学
炎症

2001-08--2005-05   德国慕尼黑技术大学   博士
1997-09--2000-07   山东师范大学，中科院上海细胞生物学研究所（联合培养）   硕士
1993-09--1997-07   山东师范大学   学士

1.2010/5-至今，中国科学院上海巴斯德研究所，天然免疫研究组，研究员
2.2005/5-2010/4，美国国家卫生研究院，过敏与传染病研究所，博士后
3.2000/9-2001/7，德国汉堡马普学会，结构与分子生物学实验室，访问学者​

2010-05~现在, 中国科学院上海巴斯德研究所, 研究员
2005-05~2009-12,美国国立卫生研究院, 博士后

2013-04-08-今,上海市细胞生物学学会理事,
2011-09-01-今,上海市微生物学会会员,
2010-09-01-今,中国免疫学会会员,
2010-09-01-今,中国细胞生物学学会会员,

高级免疫学与病毒学系列讲座

（1） 赛诺菲-安万特-中科院上海生命科学研究院优秀青年人才奖, , 其他, 2011
（2） 国家优秀自费留学生奖学金, , 国家级, 2004

[1] 孟广勋, 姚羽慧, 崔蒙蒙. 一种新型抗鼠NLRP3单克隆抗体的制备及应用. 202311060830.9, 2023-08-22.
[2] 孟广勋, 姚福家, 李政. 抑制多种病毒感染的药物及其联用. CN: CN108938637B, 2023-07-21.
[3] 孟广勋, 陈梦丹. 一种构建诱导表达NLRP3 CAPS突变体THP1细胞系的方法及应用. 202310651431.3, 2023-06-06.
[4] 孟广勋, 姚俞洁, 李娟, 冯岁寒. 具有抗病毒功能的芽胞杆菌菌株LYM3及其应用. 202310657117.6, 2023-06-05.
[5] 孟广勋, 沈俊辰. 新型IL-18抑癌功能形式短IL-18及其应用. 202310654556.1, 2023-06-05.
[6] 孟广勋, 牛俊领, 赵立平, 张晨虹. 假长双歧杆菌及其应用. CN: CN115584328A, 2023-01-10.
[7] 孟广勋, 李娟. 一种抗病毒蛋白酶CPAVM1及其应用. 202211468718.4, 2022-11-23.
[8] 孟广勋, 喻实. 基于S蛋白R815位点的冠状病毒干预的方法和产品. CN: CN114957409A, 2022-08-30.
[9] 孟广勋, 牛俊领. 假长双歧杆菌及其应用. 202110763051.X, 2021-07-07.
[10] 孟广勋, 喻实. 基于S 蛋白R815 位点的冠状病毒干预的方法和产品. 202110220208.4, 2020-09-05.
[11] 孟广勋, 姚福家, 李政. 抑制多种病毒感染的药物及其联用. CN108938637A, 2018-12-07.
[12] 孟广勋, 王洪斌. 铁离子在抑制RNA病毒中的应用. CN: CN108014129A, 2018-05-11.
[13] 孟广勋, 王洪斌. 柠檬酸根离子和铁离子在抑制RNA病毒中的应用. CN106581052A, 2017-04-26.
[14] 孟广勋, 王洪斌. 柠檬酸根离子和铁离子在抑制RNA病毒中的应用. CN: CN106581052A, 2017-04-26.

   

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[45] Caiqin Guo, Mingkuan Chen, Zhenzong Fa, Ailing Lu, Wei Fang, Bing Sun, Changbin Chen, Wanqing Liao, Guangxun Meng. Acapsular Cryptococcus neoformans activates the NLRP3 inflammasome. MICROBES AND INFECTION. 2014, 第 9 作者845-854, http://dx.doi.org/10.1016/j.micinf.2014.08.013.
[46] Chen, Wei, Xu, Yongfen, Li, Hua, Tao, Wanyin, Xiang, Yu, Huang, Bing, Niu, Junqi, Zhong, Jin, Meng, Guangxun. HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells. PLOS ONE[J]. 2014, 第 9 作者9(1): https://doaj.org/article/4d263f5c99854e5999c11cfdcc85f5b0.
[47] Song, Xinyang, Gao, Hanchao, Lin, Yingying, Yao, Yikun, Zhu, Shu, Wang, Jingjing, Liu, Yan, Yao, Xiaomin, Meng, Guangxun, Shen, Nan, Shi, Yufang, Iwakura, Yoichiro, Qian, Youcun. Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. IMMUNITY[J]. 2014, 第 9 作者40(1): 140-152, http://dx.doi.org/10.1016/j.immuni.2013.11.018.
[48] Watanabe, T, Asano, N, Meng, G, Yamashita, K, Arai, Y, Sakurai, T, Kudo, M, Fuss, I J, Kitani, A, Shimosegawa, T, Chiba, T, Strober, W. NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6. MUCOSAL IMMUNOLOGY[J]. 2014, 7(6): 1312-1325, https://www.webofscience.com/wos/woscc/full-record/WOS:000344091700004.
[49] Mao, Liming, Zhang, Liping, Li, Hua, Chen, Wei, Wang, Hongbin, Wu, Shuxian, Guo, Caiqin, Lu, Ailing, Yang, Guiwen, An, Liguo, Abliz, Paride, Meng, Guangxun. Pathogenic Fungus Microsporum canis Activates the NLRP3 Inflammasome. INFECTION AND IMMUNITY[J]. 2014, 第 12 作者  通讯作者  82(2): 882-892, https://www.webofscience.com/wos/woscc/full-record/WOS:000330357100039.
[50] Meng Guangxun. Pathogenic Fungus Microsporum canis Activates the NLRP3 Inflammasome.. INFECT IMMUN.. 2013, 第 1 作者  通讯作者  
[51] Meng Guangxun. Alarmin HNP-1 promotes pyroptosis and IL-1b release through different roles of NLRP3 inflammasome. Innate Immunity. 2013, 第 1 作者  通讯作者  
[52] Mao, Kairui, Chen, Shuzhen, Chen, Mingkuan, Ma, Yonglei, Wang, Yan, Huang, Bo, He, Zhengyu, Zeng, Yan, Hu, Yu, Sun, Shuhui, Li, Jing, Wu, Xiaodong, Wang, Xiangrui, Strober, Warren, Chen, Chang, Meng, Guangxun, Sun, Bing. Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. CELL RESEARCH[J]. 2013, 第 16 作者23(2): 201-212, http://www.irgrid.ac.cn/handle/1471x/756526.
[53] Lei, Guowei, Chen, Mingkuan, Li, Hua, Niu, JunLing, Wu, Shuxian, Mao, Liming, Lu, Ailing, Wang, Hongbin, Chen, Wei, Xu, Bin, Leng, Qibin, Xu, Cunshuan, Yang, Guiwen, An, Liguo, Zhu, LiPing, Meng, Guangxun. Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome. CELL RESEARCH[J]. 2013, 第 16 作者  通讯作者  23(7): 965-968, https://www.webofscience.com/wos/woscc/full-record/WOS:000321113700014.
[54] Meng Guangxun. Pannexin-1 infl uences peritoneal cavity cell. Protein Cell. 2013, 第 1 作者  通讯作者  
[55] Wang, Yan, Yang, Chen, Mao, Kairui, Chen, Shuzhen, Meng, Guangxun, Sun, Bing. Cellular localization of NLRP3 inflammasome. PROTEIN & CELL[J]. 2013, 第 5 作者  通讯作者  4(6): 425-431, https://www.webofscience.com/wos/woscc/full-record/WOS:000320329700003.
[56] Li, Hua, Wu, Shuxian, Mao, Liming, Lei, Guowei, Zhang, Liping, Lu, Ailing, An, Liguo, Yang, Guiwen, Abliz, Paride, Meng, Guangxun. Human pathogenic fungus Trichophyton schoenleinii activates the NLRP3 inflammasome. PROTEIN & CELL[J]. 2013, 第 10 作者4(7): 529-538, https://www.webofscience.com/wos/woscc/full-record/WOS:000322393900007.
[57] Wang, Hongbin, Mao, Liming, Meng, Guangxun. The NLRP3 inflammasome activation in human or mouse cells, sensitivity causes puzzle. PROTEIN & CELL[J]. 2013, 第 3 作者  通讯作者  4(8): 565-568, https://www.webofscience.com/wos/woscc/full-record/WOS:000322394300002.
[58] Meng Guangxun. The NLRP3 Infl ammasome activation in human. Protein Cell. 2013, 第 1 作者  通讯作者  
[59] Meng Guangxun. HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells.. PLOS ONE. 2013, 第 1 作者  通讯作者  
[60] Xu, Yongfen, Li, Hua, Chen, Wei, Yao, Xiaomin, Xing, Yue, Wang, Xun, Zhong, Jin, Meng, Guangxun. Mycoplasma hyorhinis Activates the NLRP3 Inflammasome and Promotes Migration and Invasion of Gastric Cancer Cells. PLOS ONE[J]. 2013, 第 8 作者8(11): https://doaj.org/article/ef11198478194558ad78a4bd5d884fe0.
[61] Wang, Hongbin, Xing, Yue, Mao, Liming, Luo, Yi, Kang, Lishan, Meng, Guangxun. Pannexin-1 influences peritoneal cavity cell population but is not involved in NLRP3 inflammasome activation. PROTEINCELL[J]. 2013, 第 6 作者  通讯作者  4(4): 259-265, https://www.webofscience.com/wos/woscc/full-record/WOS:000317018000004.
[62] Nakamura, Yuumi, Franchi, Luigi, Kambe, Naotomo, Meng, Guangxun, Strober, Warren, Nunez, Gabriel. Critical Role for Mast Cells in Interleukin-1 beta-Driven Skin Inflammation Associated with an Activating Mutation in the NIrp3 Protein. IMMUNITY[J]. 2012, 第 4 作者37(1): 85-95, https://www.webofscience.com/wos/woscc/full-record/WOS:000307133200012.
[63] Yuumi Nakamura, Luigi Franchi, Naotomo Kambe, Guangxun Meng, Warren Strober, Gabriel Nez. Critical Role for Mast Cells in Interleukin-1β-Driven Skin Inflammation Associated with an Activating Nlrp3 Mutation. IMMUNITY. 2012, 第 4 作者37(1): 85-95, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411177/.
[64] 雷国伟, 毛立明, 李华, 安利国, 杨桂文, 孟广勋. 炎症小体在对抗微生物感染中的作用. 中国细胞生物学学报[J]. 2011, 第 6 作者33(12): 1301-1315, http://lib.cqvip.com/Qikan/Article/Detail?id=40304878.
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[66] Meng, Guangxun, Strober, Warren. New insights into the nature of autoinflammatory diseases from mice with Nlrp3 mutations. EUROPEAN JOURNAL OF IMMUNOLOGY[J]. 2010, 第 1 作者40(3): 649-653, https://www.webofscience.com/wos/woscc/full-record/WOS:000275935600015.
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（ 1 ） 诱导多能干细胞治疗NLRP3相关自发炎症的研究, 主持, 国家级, 2012-01--2015-12
（ 2 ） 难治性丙肝转归预警预测的研究, 主持, 国家级, 2012-01--2015-12
（ 3 ） NLRP3炎症小体识别新生隐球菌生物膜的机理与功能研究, 主持, 国家级, 2014-01--2017-12
（ 4 ） 狼疮靶器官受损相关炎症通路活化的细胞及分子调节机制研究, 参与, 国家级, 2014-04--2019-04
（ 5 ） 优化NLRP3突变小鼠并研究其抗流感功能及机制, 参与, 国家级, 2014-01--2016-12
（ 6 ） 白细胞介素在胃肠癌发生发展中的协作机制, 参与, 国家级, 2015-01--2017-12
（ 7 ） HCV感染与宿主天然免疫系统相互识别与调节的机理研究, 参与, 国家级, 2015-01--2019-08
（ 8 ） NLRP3炎症小体对肠道病毒71型识别与应答的分子和细胞机, 主持, 国家级, 2016-01--2019-12
（ 9 ） NLRP3炎症小体与利什曼原虫的相互调控研究, 主持, 部委级, 2016-01--2018-12
（ 10 ） Role of pattern recognition receptors, inflammasome, and microbial capsule in host response to skin and scalp microbiome, 主持, 院级, 2016-07--2018-01

（1）EV71病毒与NLRP3炎症小体的相互调控研究   法国巴斯德所国际网络科技论坛   王洪斌   2015-10-14
（2）Nlrp3-R258W Mutation Protects Mice from Animal Models of Colitis and Colorectal Cancer”   第十七届国际粘膜免疫学大会   姚小敏   2015-07-14
（3）NLRP3-R258W MUTATION PROTECTS MICE FROM EXPERIMENTAL COLITIS AND COLORECTAL CANCER”   第六届FIMSA免疫学大会   姚小敏   2015-06-30
（4）Function of the inflammasome in the host defense against Cryptococcus neoformans infection   Guangxun Meng   2014-05-15
（5）An Essential Role for the NLRP3 Inflammasome in Host Defense against Cryptococcus neoformans infection   2012 上海国际医学真菌学高峰论坛   孟广勋   2012-11-15
（6）Blau Syndrome-Associated NOD2 Mutation Results in Loss of Regulatory Function   Guangxun MENG   2011-11-18
（7）IL-17 dominant Inflammation from Mice with Nlrp3 Mutation in Experimental Uveitis   中国免疫学会第六次全国会员代表大会第七届学术会议   Guangxun Meng   2010-10-22
（8）Interleukine-17 dominant inflammation in Experimental Uveitis from Mice with Nlrp3 Mutation   Guangxun Meng, Phyllis B. Silver, Rachel R. Caspi, and Warren Strober   2010-07-17

已指导学生

陈明宽  01  19178  

王洪斌  01  19178  

陈伟  01  19178  

薛广  02  63228  

现指导学生

姚小敏  01  19178  

邢跃  01  19178  

姚福家  02  63228  

陈义辉  01  19182  

吴淑娴  01  19182