基本信息
慈维敏  女  博导  中国科学院北京基因组研究所(国家生物信息中心)
电子邮件: ciwm@big.ac.cn
通信地址: 北京市朝阳区北辰西路1号院104号楼
邮政编码: 100101

研究领域

主要研究领域:泌尿系统肿瘤表观遗传研究

重要研究进展:

  1. ​发现表观重编程和转录态重塑调控泌尿系统肿瘤新机制

  2. 基于尿液多组学特征的泌尿系统肿瘤精准诊断技术研发及其临床应用 


招生专业

基因组学

生物信息学

精准医学


教育背景

1999-09--2004-07   中科院生物物理研究所   博士
1995-09--1999-07   北京师范大学   学士

工作经历

   
工作简历
2014-01~现在, 中国科学院北京基因组研究所(国家生物信息中心), 研究员
2009-08~2013-12,中国科学院北京基因组研究所, 副研究员
2008-03~2009-08,Weill Cornell Medicine College, 博士后
2004-10~2008-03,Albert Einstein College of Medicine, 博士后
社会兼职
2020-12-01-今,中国抗癌协会第七届肿瘤标志专业委员会, 委员
2019-12-01-今,中国细胞生物学会衰老细胞生物学分会, 理事
2019-12-01-今,中国抗癌协会肿瘤标志专业委员会甲基化标志物专家委员会, 常委
2017-12-31-今,中国抗癌协会, 会员
2017-09-01-今,中国遗传学会, 会员
2017-01-01-今,Current opinion in Urology, 编委

教授课程

精准医学概论
表观遗传学
组学当代话题
Omics
表观基因组学
人类基因组学研究-进展与应用
生物适应和基因组变异
基因组学

专利与奖励

   
奖励信息
(1) 2021年北京市科学技术奖自然科学奖, 二等奖, 市地级, 2022
(2) 肿瘤标志物及中西医结合诊疗创新技术评选, 二等奖, 其他, 2022
(3) 中国研究型医院学会医学科技奖, 二等奖, 其他, 2021
(4) 中国医院协会医院科技创新奖, 二等奖, 其他, 2021
专利成果
[1] 慈维敏, 许争争, 周利群. 一种尿沉渣基因组DNA的分类方法、装置和用途. CN: CN111833965A, 2020-10-27.
[2] 慈维敏, 葛广哲, 周媛媛, 李学松. 一种cfDNA分类方法、装置和用途. CN: CN111833963A, 2020-10-27.
[3] 慈维敏. 维生素C衍生物在制备抗肿瘤产品中的应用. CN: CN108567774A, 2018-09-25.
[4] 陈科, 慈维敏. 一种石蜡DNA纯化方法及其在基因组学中的应用. CN: CN105274090A, 2016-01-27.

出版信息

   
发表论文
[1] ChengJie Ma, Gaojie Li, WenXuan Shao, YiHao Min, Ping Wang, JiangHui Ding, NengBin Xie, Min Wang, Feng Tang, YuQi Feng, Weimin Ci, Yinsheng Wang, BiFeng Yuan. Single-Nucleotide Resolution Mapping of N 6 -Methyladenine in Genomic DNA. ACS CENTRAL SCIENCE[J]. 2023, 第 11 作者  通讯作者  9(9): 1799-1809, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540296/.
[2] Wu, Zeming, Lu, Mingming, Liu, Di, Shi, Yue, Ren, Jie, Wang, Si, Jing, Ying, Zhang, Sheng, Zhao, Qian, Li, Hongyu, Yu, Zihui, Liu, Zunpeng, Bi, Shijia, Wei, Tuo, Yang, YunGui, Xiao, Jingfa, Belmonte, Juan Carlos Izpisua, Qu, Jing, Zhang, Weiqi, Ci, Weimin, Liu, GuangHui. m 6 A epitranscriptomic regulation of tissue homeostasis during primate aging. NATURE AGING[J]. 2023, 第 20 作者  通讯作者  3(6): 705-+, http://dx.doi.org/10.1038/s43587-023-00393-2.
[3] Ren, Jie, Song, Moshi, Zhang, Weiqi, Cai, JianPing, Cao, Feng, Cao, Zhongwei, Chan, Piu, Chen, Chang, Chen, Guobing, Chen, HouZao, Chen, Jun, Chen, XiaoChun, Ci, Weimin, Ding, BiSen, Ding, Qiurong, Gao, Feng, Gao, Shaorong, Han, JingDong J, He, QiYang, Huang, Kai, Ju, Zhenyu, Kong, QingPeng, Li, Ji, Li, Jian, Li, Jingyi, Li, Xin, Liu, Baohua, Liu, Feng, Liu, JunPing, Liu, Lin, Liu, Qiang, Liu, Qiang, Liu, Xingguo, Liu, Yong, Luo, Xianghang, Ma, Shuai, Ma, Xinran, Mao, Zhiyong, Nie, Jing, Peng, Yaojin, Qu, Jing, Ren, Ruibao, Song, Weihong, Songyang, Zhou, Sun, Liang, Sun, Yi Eve, Sun, Yu, Tian, Mei, Tian, XiaoLi, Tian, Ye, Wang, Jianwei, Wang, Shusen, Wang, Si, Wang, Wengong, Wang, Xia, Wang, Xiaoning, Wang, YanJiang, Wang, Yunfang, Wong, Catherine C L, Xiang, Andy Peng, Xiao, Yichuan, Xiao, ZhiXiong, Xie, Zhengwei, Xiong, Wei, Xu, Daichao, Yang, Ze, Ye, Jing, Yu, Wei, Yue, Rui, Zhang, Cuntai, Zhang, Hongbo, Zhang, Liang, Zhang, Xinchao, Zhang, Yong, Zhang, YunWu, Zhang, Zhuohua, Zhao, Tongbiao, Zhao, Yuzheng, Zhou, Zhongjun, Zhu, Dahai, Zou, Weiguo, Pei, Gang, Liu, GuangHui. The Aging Biomarker Consortium represents a new era for aging research in China. NATURE MEDICINE[J]. 2023, 第 13 作者29(9): 2162-2165, http://dx.doi.org/10.1038/s41591-023-02444-y.
[4] Ping Wang, Yue Shi, Jianye Zhang, Jianzhong Shou, Mingxin Zhang, Daojia Zou, Yuan Liang, Juan Li, Yezhen Tan, Mei Zhang, Xingang Bi, Liqun Zhou, Weimin Ci, Xuesong Li. UCseek: ultrasensitive early detection and recurrence monitoring of urothelial carcinoma by shallow-depth genome-wide bisulfite sequencing of urinary sediment DNA. EBIOMEDICINE[J]. 2023, 第 13 作者  通讯作者  89: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941055/.
[5] Bao, Hainan, Cao, Jiani, Chen, Mengting, Chen, Min, Chen, Wei, Chen, Xiao, Chen, Yanhao, Chen, Yu, Chen, Yutian, Chen, Zhiyang, Chhetri, Jagadish K, Ding, Yingjie, Feng, Junlin, Guo, Jun, Guo, Mengmeng, He, Chuting, Jia, Yujuan, Jiang, Haiping, Jing, Ying, Li, Dingfeng, Li, Jiaming, Li, Jingyi, Liang, Qinhao, Liang, Rui, Liu, Feng, Liu, Xiaoqian, Liu, Zuojun, Luo, Oscar Junhong, Lv, Jianwei, Ma, Jingyi, Mao, Kehang, Nie, Jiawei, Qiao, Xinhua, Sun, Xinpei, Tang, Xiaoqiang, Wang, Jianfang, Wang, Qiaoran, Wang, Siyuan, Wang, Xuan, Wang, Yaning, Wang, Yuhan, Wu, Rimo, Xia, Kai, Xiao, FuHui, Xu, Lingyan, Xu, Yingying, Yan, Haoteng, Yang, Liang, Yang, Ruici, Yang, Yuanxin, Ying, Yilin, Zhang, Le, Zhang, Weiwei, Zhang, Wenwan, Zhang, Xing, Zhang, Zhuo, Zhou, Min, Zhou, Rui, Zhu, Qingchen, Zhu, Zhengmao, Cao, Feng, Cao, Zhongwei, Chan, Piu, Chen, Chang, Chen, Guobing, Chen, HouZao, Chen, Jun, Ci, Weimin, Ding, BiSen, Ding, Qiurong, Gao, Feng, Han, JingDong J, Huang, Kai, Ju, Zhenyu, Kong, QingPeng, Li, Ji, Li, Jian, Li, Xin, Liu, Baohua, Liu, Feng, Liu, Lin, Liu, Qiang, Liu, Qiang, Liu, Xingguo, Liu, Yong, Luo, Xianghang, Ma, Shuai, Ma, Xinran, Mao, Zhiyong, Nie, Jing, Peng, Yaojin, Qu, Jing, Ren, Jie, Ren, Ruibao, Song, Moshi, Zhou Songyang, Sun, Yi Eve, Sun, Yu, Tian, Mei, Wang, Shusen, Wang, Si, Wang, Xia, Wang, Xiaoning, Wang, YanJiang, Wang, Yunfang, Wong, Catherine C L, Xiang, Andy Peng, Xiao, Yichuan, Xie, Zhengwei, Xu, Daichao, Ye, Jing, Yue, Rui, Zhang, Cuntai, Zhang, Hongbo, Zhang, Liang, Zhang, Weiqi, Zhang, Yong, Zhang, YunWu, Zhang, Zhuohua, Zhao, Tongbiao, Zhao, Yuzheng, Zhu, Dahai, Zou, Weiguo, Pei, Gang, Liu, GuangHui, Aging Biomarker Consortium. Biomarkers of aging. SCIENCE CHINA-LIFE SCIENCES[J]. 2023, 第 68 作者  通讯作者  66(5): 893-1066, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7491049&detailType=1.
[6] Zeming Wu, Mingming Lu, Di Liu, Yue Shi, Jie Ren, Si Wang, Ying Jing, Sheng Zhang, Qian Zhao, Hongyu Li, Zhihui Yu, Zunpeng Liu, Shijia Bi, Tuo Wei, YunGui Yang, Jingfa Xiao, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Weimin Ci, GuangHui Liu. m6A epitranscriptomic regulation of tissue homeostasis during primate aging.. Nature Aging[J]. 2023, 第 20 作者  通讯作者  3: 705-721, 
[7] Ge, Guangzhe, Han, Yang, Zhang, Jianye, Li, Xinxin, Liu, Xiaodan, Gong, Yanqing, Lei, Zhentao, Wang, Jie, Zhu, Weijie, Xu, Yangyang, Peng, Yiji, Deng, Jianhua, Zhang, Bao, Li, Xuesong, Zhou, Liqun, He, Huiying, Ci, Weimin. Single-Cell RNA-seq Reveals a Developmental Hierarchy Super-Imposed Over Subclonal Evolution in the Cellular Ecosystem of Prostate Cancer. ADVANCED SCIENCE[J]. 2022, 第 17 作者  通讯作者  9(15): https://www.doi.org/10.1002/advs.202105530.
[8] Shi, Yue, Zhang, Qi, Bi, Hai, Lu, Min, Tan, Yezhen, Zou, Daojia, Ge, Liyuan, Chen, Zhigang, Liu, Cheng, Ci, Weimin, Ma, Lulin. Decoding the multicellular ecosystem of vena caval tumor thrombus in clear cell renal cell carcinoma by single-cell RNA sequencing. GENOME BIOLOGY[J]. 2022, 第 10 作者  通讯作者  23(1): http://dx.doi.org/10.1186/s13059-022-02651-9.
[9] Li, Juan, Liang, Yuan, Fan, Jian, Xu, Chunru, Guan, Bao, Zhang, Jianye, Guo, Bin, Shi, Yue, Wang, Ping, Tan, Yezhen, Zhang, Qi, Yuan, Changwei, Wu, Yucai, Zhou, Liqun, Ci, Weimin, Li, Xuesong. DNA methylation subtypes guiding prognostic assessment and linking to responses the DNA methyltransferase inhibitor SGI-110 in urothelial carcinoma. BMCMEDICINE[J]. 2022, 第 15 作者  通讯作者  20(1): 
[10] Xiong, Jun, Wang, Ping, Shao, WenXuan, Li, Gaojie, Ding, JiangHui, Xie, NengBin, Wang, Min, Cheng, QingYun, Xie, Conghua, Feng, YuQi, Ci, Weimin, Yuan, BiFeng. Genome-wide mapping of N-4-methylcytosine at single-base resolution by APOBEC3A-mediated deamination sequencing. CHEMICAL SCIENCE[J]. 2022, 第 11 作者  通讯作者  13(34): 9960-9972, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000840407100001.
[11] Yuan Liang, Yezhen Tan, Bao Guan, Bin Guo, Mancheng Xia, Juan Li, Yue Shi, Zihui Yu, Qi Zhang, Di Liu, Xiaopeng Yang, Junfeng Hao, Yanqing Gong, Muhanmmad Shakeel, Liqun Zhou, Weimin Ci, Xuesong Li. Single-cell atlases link macrophages and CD8+ T-cell subpopulations to disease progression and immunotherapy response in urothelial carcinoma. THERANOSTICS[J]. 2022, 第 16 作者  通讯作者  
[12] Zhang, Jianye, Zhang, Qi, Shi, Yue, Wang, Ping, Gong, Yanqing, He, Shiming, Li, Zhihua, Feng, Ninghan, Wang, Yang, Jiang, Peng, Ci, Weimin, Li, Xuesong, Zhou, Liqun. Metabolism-Related Signature Analysis Uncovers the Prognostic and Immunotherapeutic Characteristics of Renal Cell Carcinoma. FRONTIERS IN MOLECULAR BIOSCIENCES[J]. 2022, 第 11 作者  通讯作者  9: http://dx.doi.org/10.3389/fmolb.2022.837145.
[13] Zhang, Qi, Tan, Yezhen, Zhang, Jianye, Shi, Yue, Qi, Jie, Zou, Daojia, Ci, Weimin. Pyroptosis-Related Signature Predicts Prognosis and Immunotherapy Efficacy in Muscle-Invasive Bladder Cancer. FRONTIERS IN IMMUNOLOGY[J]. 2022, 第 7 作者  通讯作者  13: http://dx.doi.org/10.3389/fimmu.2022.782982.
[14] Qi, Jie, Shi, Yue, Tan, Yezhen, Zhang, Qi, Zhang, Jianye, Wang, Jilu, Huang, Cong, Ci, Weimin. Regional gain and global loss of 5-hydroxymethylcytosine coexist in genitourinary cancers and regulate different oncogenic pathways. CLINICAL EPIGENETICS[J]. 2022, 第 8 作者  通讯作者  14(1): http://dx.doi.org/10.1186/s13148-022-01333-4.
[15] Peng, Ding, He, Anbang, He, Shiming, Ge, Guangzhe, Wang, Shuo, Ci, Weimin, Li, Xuesong, Xia, Dan, Zhou, Liqun. Ascorbic acid induced TET2 enzyme activation enhances cancer immunotherapy efficacy in renal cell carcinoma. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2022, 第 6 作者18(3): 995-1007, http://dx.doi.org/10.7150/ijbs.67329.
[16] Yu, Zihui, Xu, Ziying, Liang, Yuan, Yin, Pengbin, Shi, Yue, Yu, Jiayi, Hao, Junfeng, Wang, Ting, Ci, Weimin. Vitamin C Deficiency Causes Cell Type?Specific Epigenetic Reprogramming and Acute Tubular Necrosis in a Mouse Model. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY[J]. 2022, 第 9 作者  通讯作者  33(3): 531-546, http://dx.doi.org/10.1681/ASN.2021070881.
[17] Zhang, Sheng, Wu, Zeming, Shi, Yue, Wang, Si, Ren, Jie, Yu, Zihui, Huang, Daoyuan, Yan, Kaowen, He, Yifang, Liu, Xiaoqian, Ji, Qianzhao, Liu, Beibei, Liu, Zunpeng, Qu, Jing, Liu, GuangHui, Ci, Weimin, Wang, Xiaoqun, Zhang, Weiqi. FTO stabilizes MIS12 and counteracts senescence. PROTEIN & CELL[J]. 2022, 第 16 作者  通讯作者  13(12): 954-960, http://dx.doi.org/10.1007/s13238-022-00914-6.
[18] Liang, Yuan, Tan, Yezhen, Guan, Bao, Guo, Bin, Xia, Mancheng, Li, Juan, Shi, Yue, Yu, Zihui, Zhang, Qi, Liu, Di, Yang, Xiaopeng, Hao, Junfeng, Gong, Yanqing, Shakeel, Muhammad, Zhou, Liqun, Ci, Weimin, Li, Xuesong. Single-cell atlases link macrophages and CD8+T-cell subpopulations to disease progression and immunotherapy in urothelial carcinoma. THERANOSTICS[J]. 2022, 第 16 作者  通讯作者  12(18): 7745-7759, http://dx.doi.org/10.7150/thno.77281.
[19] Ma, Qin, Wang, Jilu, Qi, Jie, Peng, Ding, Guan, Bao, Zhang, Jianye, Li, Zhongwu, Zhang, Hongxian, Li, Ting, Shi, Yue, Li, Xuesong, Zhou, Liqun, Chen, Ke, Ci, Weimin. Increased chromosomal instability characterizes metastatic renal cell carcinoma. TRANSLATIONAL ONCOLOGY[J]. 2021, 第 14 作者  通讯作者  14(1): https://doaj.org/article/3367bb42b11a4f0abf3594d983b546d2.
[20] Han, Yang, Li, Xinxin, Zhang, Mingxin, Yang, Yang, Ge, Guangzhe, Wang, Kunxiang, Gong, Yanqing, Liang, Yuan, Niu, Haitao, Ci, Weimin. Enhanced Detection of Genitourinary Cancers Using Fragmentation and Copy Number Profiles Obtained from Urinary Cell-Free DNA. CLINICAL CHEMISTRY[J]. 2021, 第 10 作者  通讯作者  67(2): 394-403, https://www.webofscience.com/wos/woscc/full-record/WOS:000614680300010.
[21] Guan, Bao, Liang, Yuan, Lu, Huan, Xu, Zhengzheng, Shi, Yue, Li, Juan, Kong, Wenwen, Tian, Chuanyu, Tan, Yezhen, Gong, Yanqing, Liu, Jin, Fang, Dong, Shen, Qi, He, Shiming, Shakeel, Muhammad, Zhang, Zhongyuan, He, Qun, Li, Xuesong, Ci, Weimin, Zhou, Liqun. Copy Number Signatures and Clinical Outcomes in Upper Tract Urothelial Carcinoma. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2021, 第 19 作者  通讯作者  9: http://dx.doi.org/10.3389/fcell.2021.713499.
[22] Zhang, Jianye, Fan, Jian, Wang, Ping, Ge, Guangzhe, Li, Juan, Qi, Jie, Kong, Wenwen, Gong, Yanqing, He, Shiming, Ci, Weimin, Li, Xuesong, Zhou, Liqun. Construction of diagnostic and subtyping models for renal cell carcinoma by genome-wide DNA methylation profiles. TRANSLATIONAL ANDROLOGY AND UROLOGY[J]. 2021, 第 10 作者  通讯作者  10(11): 4161-+, http://dx.doi.org/10.21037/tau-21-674.
[23] Ci Weimin. The RNA N6-methyladenosine methyltransferase METTL3 promotes the progression of kidney cancer via m6A-dependent translational enhancement of ABCD1. Frontiers in Cell and Developmental Biology. 2021, 第 1 作者  通讯作者  
[24] Wu, Zeming, Shi, Yue, Lu, Mingming, Song, Moshi, Yu, Zihui, Wang, Jilu, Wang, Si, Ren, Jie, Yang, YunGui, Liu, GuangHui, Zhang, Weiqi, Ci, Weimin, Qu, Jing. METTL3 counteracts premature aging via m(6)A-dependent stabilization of MIS12 mRNA. NUCLEIC ACIDS RESEARCH[J]. 2020, 第 12 作者  通讯作者  48(19): 11083-11096, https://www.webofscience.com/wos/woscc/full-record/WOS:000606018400039.
[25] Xu, Zhengzheng, Ge, Guangzhe, Guan, Bao, Lei, Zhentao, Hao, Xueyu, Zhou, Yuanyuan, Shi, Yue, Lu, Huan, Wang, Jilu, Peng, Ding, Wu, XiKang, He, Huiying, Zhang, Bao, Li, Xuesong, Zhou, Liqun, Ci, Weimin. Reply to Yejinpeng Wang, Yaoyi Xiong, and Xinghuan Wang's Letter to the Editor re: Zhengzheng Xu, Guangzhe Ge, Bao Guan, et al. Noninvasive Detection and Localization of Genitourinary Cancers Using Urinary Sediment DNA Methylomes and Copy Number Profiles. Eur Urol 2020;77:288-90. EUROPEAN UROLOGY. 2020, 第 16 作者  通讯作者  77(4): E91-E92, http://dx.doi.org/10.1016/j.eururo.2019.12.013.
[26] Ge, Guangzhe, Peng, Ding, Guan, Bao, Zhou, Yuanyuan, Gong, Yanqing, Shi, Yue, Hao, Xueyu, Xu, Zhengzheng, Qi, Jie, Lu, Huan, Zhang, Xiaoyun, Zhan, Yonghao, Li, Yifan, Wu, Yucai, Ding, Guangpu, Shen, Qi, He, Qun, Li, Xuesong, Zhou, Liqun, Ci, Weimin. Urothelial Carcinoma Detection Based on Copy Number Profiles of Urinary Cell-Free DNA by Shallow Whole-Genome Sequencing. CLINICAL CHEMISTRY[J]. 2020, 第 20 作者  通讯作者  66(1): 188-198, https://www.webofscience.com/wos/woscc/full-record/WOS:000514384200031.
[27] Lu, Huan, Liang, Yuan, Guan, Bao, Shi, Yue, Gong, Yanqing, Li, Juan, Kong, Wenwen, Liu, Jin, Fang, Dong, Liu, Libo, He, Qun, Shakeel, Muhammad, Li, Xuesong, Zhou, Liqun, Ci, Weimin. Aristolochic acid mutational signature defines the low-risk subtype in upper tract urothelial carcinoma. THERANOSTICS[J]. 2020, 第 15 作者  通讯作者  10(10): 4323-4333, https://www.webofscience.com/wos/woscc/full-record/WOS:000522665800003.
[28] Lu, Feng, Zhou, Qian, Liu, Lu, Zeng, Guandi, Ci, Weimin, Liu, Wanting, Zhang, Gong, Zhang, Zhiyi, Wang, Peng, Zhang, Aiqun, Gao, Yunfei, Yu, Lei, He, Qingyu, Chen, Liang. A tumor suppressor enhancing module orchestrated by GATA4 denotes a therapeutic opportunity for GATA4 deficient HCC patients. THERANOSTICS[J]. 2020, 第 5 作者10(2): 484-497, http://dx.doi.org/10.7150/thno.38060.
[29] Ci Weimin. Detection of urothelial carcinoma based on copy number profiles of urinary cell-free DNA using shallow whole-genome sequencing. Clinical Chemistry. 2020, 第 1 作者  通讯作者  
[30] Xu, Zhengzheng, Ge, Guangzhe, Guan, Bao, Lei, Zhentao, Hao, Xueyu, Zhou, Yuanyuan, Shi, Yue, Lu, Huan, Wang, Jilu, Peng, Ding, Wu, XiKang, He, Huiying, Zhang, Bao, Li, Xuesong, Zhou, Liqun, Ci, Weimin. Noninvasive Detection and Localization of Genitourinary Cancers Using Urinary Sediment DNA Methylomes and Copy Number Profiles. EUROPEAN UROLOGY. 2020, 第 16 作者  通讯作者  77(2): 288-290, http://dx.doi.org/10.1016/j.eururo.2019.11.006.
[31] Yan, Pengze, Liu, Zunpeng, Song, Moshi, Wu, Zeming, Xu, Wei, Li, Kuan, Ji, Qianzhao, Wang, Si, Liu, Xiaoqian, Yan, Kaowen, Esteban, Concepcion Rodriguez, Ci, Weimin, Belmonte, Juan Carlos Izpisua, Xie, Wei, Ren, Jie, Zhang, Weiqi, Sun, Qianwen, Qu, Jing, Liu, GuangHui. Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming. CELL REPORTS[J]. 2020, 第 12 作者32(1): http://dx.doi.org/10.1016/j.celrep.2020.107870.
[32] Ge, Guangzhe, Peng, Ding, Xu, Ziying, Guan, Bao, Xin, Zijuan, He, Qun, Zhou, Yuanyuan, Li, Xuesong, Zhou, Liqun, Ci, Weimin. Restoration of 5-hydroxymethylcytosine by ascorbate blocks kidney tumour growth. EMBO REPORTS[J]. 2018, 第 10 作者  通讯作者  19(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000440648700003.
[33] Xiong, Gengyan, Yao, Lin, Hong, Peng, Yang, Li, Ci, Weimin, Liu, Libo, He, Qun, Gong, Kan, Li, Xuesong, Zhou, Liqun. Aristolochic acid containing herbs induce gender-related oncological differences in upper tract urothelial carcinoma patients. CANCER MANAGEMENT AND RESEARCH[J]. 2018, 第 5 作者10: 6627-6639, https://doaj.org/article/a7218e2089af482fb5c87e679afd6241.
[34] 史悦, 许争争, 鲁欢, 慈维敏. 肿瘤突变特征与病理分型的关联研究. 遗传[J]. 2018, 第 4 作者40(11): 1033-1038, http://lib.cqvip.com/Qikan/Article/Detail?id=7000931362.
[35] Peng, Ding, Ge, Guangzhe, Gong, Yanqing, Zhan, Yonghao, He, Shiming, Guan, Bao, Li, Yifan, Xu, Ziying, Hao, Han, He, Zhisong, Xiong, Gengyan, Zhang, Cuijian, Shi, Yue, Zhou, Yuanyuan, Ci, Weimin, Li, Xuesong, Zhou, Liqun. Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer. CLINICAL EPIGENETICS[J]. 2018, 第 15 作者  通讯作者  10(1): https://doaj.org/article/96a52fee9a7147ddb66e2c71cd2d2163.
[36] Ma, Qin, Xu, Zhengzheng, Lu, Huan, Xu, Ziying, Zhou, Yuanyuan, Yuan, Bifeng, Ci, Weimin. Distal regulatory elements identified by methylation and hydroxymethylation haplotype blocks from mouse brain. EPIGENETICS & CHROMATIN[J]. 2018, 第 7 作者  通讯作者  11(1): https://doaj.org/article/67bf318ebe8c47d6b51a6ad29443db9e.
[37] 马琴, 周媛媛, 慈维敏. DNA甲基化/去甲基化与疾病概览. 生命科学[J]. 2018, 第 3 作者30(4): 366-373, http://lib.cqvip.com/Qikan/Article/Detail?id=675263903.
[38] Peng, Ding, Ge, Guangzhe, Xu, Zhengzheng, Ma, Qin, Shi, Yue, Zhou, Yuanyuan, Gong, Yanqing, Xiong, Gengyan, Zhang, Cuijian, He, Shiming, He, Zhisong, Li, Xuesong, Ci, Weimin, Zhou, Liqun. Diagnostic and prognostic biomarkers of common urological cancers based on aberrant DNA methylation. EPIGENOMICS[J]. 2018, 第 13 作者  通讯作者  10(9): 1189-1199, http://dx.doi.org/10.2217/epi-2018-0017.
[39] Valls, Ester, Lobry, Camille, Geng, Huimin, Wang, Ling, Cardenas, Mariano, Rivas, Martin, Cerchietti, Leandro, Oh, Philmo, Yang, Shao Ning, Oswald, Erin, Graham, Camille W, Jiang, Yanwen, Hatzi, Katerina, Agirre, Xabier, Perkey, Eric, Li, Zhuoning, Tam, Wayne, Bhatt, Kamala, Leonard, John P, ZweidlerMcKay, Patrick A, Maillard, Ivan, Elemento, Olivier, Ci, Weimin, Aifantis, Iannis, Melnick, Ari. BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells. CANCER DISCOVERY[J]. 2017, 第 11 作者7(5): 506-521, https://www.webofscience.com/wos/woscc/full-record/WOS:000400269300022.
[40] Ma, Qin, Lu, Huan, Xu, Ziying, Zhou, Yuanyuan, Ci, Weimin. Mouse olfactory bulb methylome and hydroxymethylome maps reveal noncanonical active turnover of DNA methylation. EPIGENETICS[J]. 2017, 第 5 作者  通讯作者  12(8): 708-714, https://www.webofscience.com/wos/woscc/full-record/WOS:000414572900011.
[41] Chen, Ke, Zhang, Jing, Guo, Zhongqiang, Ma, Qin, Xu, Zhengzheng, Zhou, Yuanyuan, Xu, Ziying, Li, Zhongwu, Liu, Yiqiang, Ye, Xiongjun, Li, Xuesong, Yuan, Bifeng, Ke, Yuwen, He, Chuan, Zhou, Liqun, Liu, Jiang, Ci, Weimin. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer. CELLRESEARCH[J]. 2016, 第 17 作者  通讯作者  26(1): 103-118, https://www.webofscience.com/wos/woscc/full-record/WOS:000367615200010.
[42] Zhang, Lei, Yin, Wenshi, Yao, Lin, Li, Xuesong, Fang, Dong, Ren, Da, Zhang, Zhongyuan, Fan, Yu, He, Qun, Ci, Weimin, He, Zhisong, Zhou, Liqun. Growth Pattern of Clear Cell Renal Cell Carcinoma in Patients with Delayed Surgical Intervention: Fast Growth Rate Correlates with High Grade and May Result in Poor Prognosis. BIOMED RESEARCH INTERNATIONAL[J]. 2015, 第 10 作者2015: https://doaj.org/article/a9e521e2fa244817a53ef544704dc045.
[43] Cheng, QingYun, Xiong, Jun, Huang, Wei, Ma, Qin, Ci, Weimin, Feng, YuQi, Yuan, BiFeng. Sensitive Determination of Onco-metabolites of D- and L-2-hydroxyglutarate Enantiomers by Chiral Derivatization Combined with Liquid Chromatography/Mass Spectrometry Analysis. SCIENTIFIC REPORTS[J]. 2015, 第 5 作者5: https://www.webofscience.com/wos/woscc/full-record/WOS:000362642500001.
[44] Guo, Zhongqiang, Liu, Jin, Zhang, Lian, Su, Boxing, Xing, Yunchao, He, Qun, Ci, Weimin, Li, Xuesong, Zhou, Liqun. KCNJ1 inhibits tumor proliferation and metastasis and is a prognostic factor in clear cell renal cell carcinoma. TUMOR BIOLOGY[J]. 2015, 第 7 作者36(2): 1251-1259, https://www.webofscience.com/wos/woscc/full-record/WOS:000350478200093.
[45] Xiong, Gengyan, Liu, Jin, Tang, Qi, Fan, Yu, Fang, Dong, Yang, Kaiwei, Xie, Feng, Zhang, Min, Zhang, Lei, Liu, Libo, Zhang, Cuijian, Yao, Lin, Yang, Li, Ci, Weimin, Zhao, Wei, Gong, Yanqing, He, Qun, Gong, Kan, He, Zhisong, Wang, Gang, Li, Xuesong, Guo, Yinglu, Zhou, Liqun. Prognostic and predictive value of epigenetic biomarkers and clinical factors in upper tract urothelial carcinoma. EPIGENOMICS[J]. 2015, 第 14 作者7(5): 733-744, http://dx.doi.org/10.2217/epi.15.34.
[46] Ci, Weimin, Liu, Jiang. Programming and Inheritance of Parental DNA Methylomes in Vertebrates. PHYSIOLOGY. 2015, 第 1 作者  通讯作者  30(1): 63-68, https://www.webofscience.com/wos/woscc/full-record/WOS:000347306100009.
[47] Zhang, Lei, Xiong, Gengyan, Fang, Dong, Li, Xuesong, Liu, Jin, Ci, Weimin, Zhao, Wei, Singla, Nirmish, He, Zhisong, Zhou, Liqun. Contralateral upper tract urothelial carcinoma after nephroureterectomy: the predictive role of DNA methylation. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH[J]. 2015, 第 6 作者34(1): http://dx.doi.org/10.1186/s13046-015-0120-2.
[48] Wang, Lu, Zhang, Jun, Duan, Jialei, Gao, Xinxing, Zhu, Wei, Lu, Xingyu, Yang, Lu, Zhang, Jing, Li, Guoqiang, Ci, Weimin, Li, Wei, Zhou, Qi, Aluru, Neel, Tang, Fuchou, He, Chuan, Huang, Xingxu, Liu, Jiang. Programming and Inheritance of Parental DNA Methylomes in Mammals. CELL[J]. 2014, 第 10 作者157(4): 979-991, http://dx.doi.org/10.1016/j.cell.2014.05.029.
[49] Li, Guoqiang, Ci, Weimin, Karmakar, Subhradip, Chen, Ke, Dhar, Ruby, Fan, Zhixiang, Guo, Zhongqiang, Zhang, Jing, Ke, Yuwen, Wang, Lu, Zhuang, Min, Hu, Shengdi, Li, Xuesong, Zhou, Liqun, Li, Xianghong, Calabrese, Matthew F, Watson, Edmond R, Prasad, Sandip M, RinkerSchaeffer, Carrie, Eggener, Scott E, Stricker, Thomas, Tian, Yong, Schulman, Brenda A, Liu, Jiang, White, Kevin P. SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer. CANCER CELL[J]. 2014, 第 2 作者25(4): 455-468, http://dx.doi.org/10.1016/j.ccr.2014.02.007.
[50] Jiang, Lan, Zhang, Jing, Wang, JingJing, Wang, Lu, Zhang, Li, Li, Guoqiang, Yang, Xiaodan, Ma, Xin, Sun, Xin, Cai, Jun, Zhang, Jun, Huang, Xingxu, Yu, Miao, Wang, Xuegeng, Liu, Feng, Wu, ChungI, He, Chuan, Zhang, Bo, Ci, Weimin, Liu, Jiang. Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos. CELL[J]. 2013, 第 19 作者  通讯作者  153(4): 773-784, http://dx.doi.org/10.1016/j.cell.2013.04.041.
[51] Ci, Weimin, Polo, Jose M, Cerchietti, Leandro, Shaknovich, Rita, Wang, Ling, Yang, Shao Ning, Ye, Kenny, Farinha, Pedro, Horsman, Douglas E, Gascoyne, Randy D, Elemento, Olivier, Melnick, Ari. The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL. BLOOD[J]. 2009, 第 1 作者113(22): 5536-5548, http://dx.doi.org/10.1182/blood-2008-12-193037.
[52] Polo, Jose M, Ci, Weimin, Licht, Jonathan D, Melnick, Ari. Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells. BLOOD[J]. 2008, 第 2 作者112(3): 644-651, https://www.webofscience.com/wos/woscc/full-record/WOS:000258257900031.
[53] Ci, Weimin, Polo, Jose M, Melnick, Ari. B-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma. CURRENT OPINION IN HEMATOLOGY[J]. 2008, 第 1 作者15(4): 381-390, https://www.webofscience.com/wos/woscc/full-record/WOS:000257379600016.
[54] Weimin Ci, Wenyu Li, Ya Ke, Zhong-Ming Qian, Xun Shen. Intracellular Ca 2+ regulates the cellular iron uptake in K562 cells. CELL CALCIUM. 2003, 第 1 作者33(4): 257-266, http://dx.doi.org/10.1016/S0143-4160(02)00240-3.

科研活动

   
科研项目
( 1 ) 生命科学领域优秀青年科技专项, 负责人, 中国科学院计划, 2011-01--2013-12
( 2 ) 自然科学基金面上项目, 负责人, 国家任务, 2012-01--2015-12
( 3 ) 肿瘤转移过程中基因突变和表观遗传变异协同性进化的规律, 负责人, 国家任务, 2013-05--2015-12
( 4 ) DNA甲基化/去甲基化重编程在泌尿系统上皮细胞分化、恶性转化、侵袭转移中的作用机理研究, 负责人, 国家任务, 2016-01--2016-12
( 5 ) 肿瘤表观基因组学, 负责人, 国家任务, 2015-01--2017-12
( 6 ) 肿瘤转移模式和表观遗传驱动力的识别, 负责人, 中国科学院计划, 2016-08--2020-12
( 7 ) 中国女性患者上尿路上皮癌复发的多基因机制研究, 负责人, 国家任务, 2017-01--2020-12
( 8 ) 表观基因组学检测技术研发与临床应用, 负责人, 国家任务, 2016-07--2018-12
( 9 ) 恶性肿瘤的基因组演化和精准医学研究, 参与, 中国科学院计划, 2016-01--2018-12
( 10 ) 王宽诚率先人才计划“卢嘉锡国际团队项目”, 负责人, 中国科学院计划, 2018-01--2020-12
( 11 ) 衰老伴随的核酸修饰变化及调控, 负责人, 中国科学院计划, 2017-12--2022-12
( 12 ) 增龄相关健康减损的生物学标志物研究, 负责人, 国家任务, 2018-12--2022-12
( 13 ) 建立性腺衰老干细胞治疗临床方案, 参与, 国家任务, 2019-10--2023-12
( 14 ) 基于多组学特征的尿路上皮癌精准分型和诊断技术研究及应用, 负责人, 国家任务, 2022-01--2025-12
( 15 ) 多层次解析肿瘤微环境驱动尿路上皮癌可塑性及药物反应研究, 负责人, 国家任务, 2023-03--2026-02
参与会议
(1)前列腺癌细胞转录态可塑性及早诊新策略   2023肿瘤基础与转化研究前沿交叉研讨会   2023-11-22
(2)前列腺癌肿瘤细胞异质性演化及转录态可塑性的关键分子特征   2023郑州大学医学国际论坛-多学科交叉前沿论坛   2023-11-17
(3)Deep learning based noninvasive genitourinary cancer detection using urine DNA methylomes   第四届国际表观基因组学研讨会暨2023中国肿瘤甲基化标志物年会   2023-10-28
(4)基于尿液DNA甲基化特征的泌尿系统肿瘤早诊深度学习模型构建   空军军医大学基础医学院“强基论坛”——交叉技术与医学转化专场   2023-09-03
(5)基于尿液DNA甲基化特征的泌尿系统肿瘤早诊深度学习模型构建   2023年度表观遗传与染色质生物学大会   2023-08-16
(6)泌尿系统肿瘤诊断和溯源的尿液液体活检技术开发和转化应用研究   TDS2023肿瘤创新分子诊断与伴随诊断论坛   2023-05-17
(7)Single-cell atlases link macrophages and CD8+ T-cell in immunotherapy response in urothelial carcinoma   European Society for Translational Medicine 2023 congress on Immunotherapeutics    2023-05-06
(8)尿液液体活检技术在泌尿肿瘤诊断和溯源中的应用研究   第五届中国生物诊断高峰论坛   2023-04-22
(9)尿液液体活检技术在泌尿肿瘤诊断和溯源中的应用研究   CCTB中国肿瘤标志物产业创新大会分论坛   2023-04-08
(10)晚期肾癌癌栓形成的分子机制研究   第一届奉天3S肿瘤高峰论坛   2023-04-01
(11)2022肿瘤基础及转化研究前沿交叉研讨会   基于多组学特征的尿路上皮癌精准分型和临床转化研究   2022-12-23
(12)前列腺癌全尿标记物的筛选研究   第九届航天前列腺癌学术暨MDT论坛   2022-12-19
(13)前列腺衰老DNA甲基化标记物研究   首届中国衰老标记物大会   2022-11-27
(14)尿路上皮癌精准诊疗亟需“中国方案”   中国肿瘤学大会(CCO)   2022-11-20
(15)基于多组学特征的尿路上皮癌精准分型和临床转化   上海市医学会东方肿瘤靶分子年会   2022-10-29
(16)维生素C在肾癌和肾损伤中的表观调控机制   北京大学第三医院第18届泌尿外科微创会议   2021-10-15
(17)肿瘤筛查,DNA甲基化Vs基因突变,如何选择?   早筛检测技术创新与临床应用   2021-09-02
(18)尿路上皮癌精准诊疗亟需“中国方案”   “对肿瘤说不,对早筛说行”大型肿瘤科普与行动   2021-05-19
(19)液体活检技术用于肿瘤诊断和分类   首届国家呼吸医学中心早癌高峰论坛   2020-12-12
(20)泌尿系统肿瘤表观遗传研究   2020年北京肿瘤学前沿交叉学术论坛   2020-11-22
(21)采用尿液液体活检技术进行泌尿系统肿瘤诊断和分类   2020中国肿瘤学大会-肿瘤标志分会场   2020-11-14
(22)基于多组学技术的泌尿系统肿瘤精准医学研究   2020第七届NGS创新开发者大会   2020-06-26
(23)第三届现代临床分子诊断论坛&第四届精准医学高峰论坛   第三届现代临床分子诊断论坛&第四届精准医学高峰论坛   2019-11-10
(24)第四届东方肿瘤分子诊断与靶向治疗学术会议   第四届东方肿瘤分子诊断与靶向治疗学术会议   2019-09-21
(25)2019年度NSFC-FDCT精准医疗学术研讨会   2019年度NSFC-FDCT精准医疗学术研讨会   2019-06-27
(26)EACR-ESMO Joint Conference on Liquid Biopsies Programme   2019-05-16
(27)Large scale genomic aberrations characterize metastatic renal cell carcinoma evolution   2018-11-01
(28)人类衰老干细胞m6A表观转录组重编程图谱和生物学功能   衰老生物学分会成立大会   2018-09-12
(29)尿路上皮癌的基因组特征及潜在治疗靶点   2018全国微创泌尿外科年会(18th)   2018-05-12
(30)SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer   Guoqiang Li#, Weimin Ci#, Subhradip Karmakar#, Ke Chen, Zhixiang Fan, Zhongqiang Guo, Jing Zhang, Lu Wang, Min Zhuang, Shengdi Hu, Xuesong Li, Xianghong Li, Erin E. Mowers, Matthew F. Calabrese, Edmond R. Watson, Sandip Prasad, Carrie Rinker-Schaeffer, Scott E. Eggener, Thomas Stricker, Yong Tian, Brenda Schulman,    2015-11-10
(31)A “survival of the Fittest” mechanism for weeding out potentially lymphomagenic B-cells during germinal center B-cell differentiation   第49界美国血液学年会   Ci, W. Polo, J.M. Ranuncolo, S.M. Melnick, A.    2007-12-08

指导学生

已指导学生

许争争  硕士研究生  085238-生物工程  

郝雪玉  硕士研究生  0710Z1-基因组学  

马琴  博士研究生  071007-遗传学  

徐子瑛  博士研究生  0710J3-生物信息学  

葛广哲  博士研究生  0710Z1-基因组学  

许争争  博士研究生  0710Z1-基因组学  

鲁欢  博士研究生  0710Z1-基因组学  

齐杰  博士研究生  0710Z1-基因组学  

樊健  博士研究生  0710J3-生物信息学  

王基陆  博士研究生  0710Z1-基因组学  

田创宇  硕士研究生  0710Z1-基因组学  

孔雯雯  硕士研究生  0710Z1-基因组学  

于子惠  博士研究生  0710Z1-基因组学  

窦延良  硕士研究生  0710Z1-基因组学  

邹道嘉  硕士研究生  1001Z1-精准医学  

韩漾  博士研究生  0710J3-生物信息学  

李娟  博士研究生  0710J3-生物信息学  

包海南  硕士研究生  1001Z1-精准医学  

现指导学生

杨洋  博士研究生  0710Z1-基因组学  

王平  博士研究生  1001Z1-精准医学  

王颖  硕士研究生  0710Z1-基因组学  

张琪  博士研究生  0710Z1-基因组学  

谭耶真  博士研究生  0710Z1-基因组学  

何玉丹  博士研究生  0710Z1-基因组学  

郭彬  博士研究生  0710Z1-基因组学  

李高杰  博士研究生  0710J3-生物信息学  

左一帆  硕士研究生  1001Z1-精准医学  

丑善源  博士研究生  0710Z1-基因组学