（1）基因组变异与肿瘤进展分子机制；（2）线粒体自稳态维持与神经退行性疾病

   

071010-生物化学与分子生物学
071007-遗传学

DNA损伤修复与肿瘤进展分子机制
线粒体自稳态与老化疾病

1998-04--2003-04   美国哥伦比亚大学   博士后
1992-08--1995-07   北京放射医学研究所   分子生物学及毒理学专业博士
1986-07--1989-08   河北医科大学预防医学系   医学硕士
1981-09--1986-07   中国医科大学   医学学士

   

2009-02~现在, 中国科学院北京基因组研究所, 研究员
2003-05~2009-01,美国哥伦比亚大学, 助理教授
1995-07~1998-04,北京放射医学研究所, 助理研究员
1989-08~1992-08,河北医科大学预防医学系, 助教

生化和分子生物学实验课
Omics Brush Class
精准医学简介
生物化学和分子生物学实验课
Omics course
分子生物学实验课
染色体结构与基因组稳定性
基因组学-肿瘤基因组学

   

（ 1 ） RecQL4基因高表达作为新型的靶点在制备抗肿瘤药物中的应用, 发明, 2009, 第 1 作者, 专利号: 200910073731
（ 2 ） RECQL4基因高表达作为靶点在制备抗胃癌药物中的应用, 发明, 2016, 第 1 作者, 专利号: 201610080641.1

   

[1] Shi, Boyang, Heng, Jian, Zhou, JiaYi, Yang, Ying, Zhang, WanYing, Koziol, Magdalena J, Zhao, YongLiang, Li, Pilong, Liu, Feng, Yang, YunGui. Phase separation of Ddx3xb helicase regulates maternal-to-zygotic transition in zebrafish. CELL RESEARCH[J]. 2022, 32(8): 715-728, http://dx.doi.org/10.1038/s41422-022-00655-5.
[2] Ge, XinYang, Han, Xiao, Zhao, YongLiang, Cui, GuanShen, Yang, YunGui. An insight into planarian regeneration. CELL PROLIFERATION. 2022, 55(9): [3] Zhang, Chuanchao, Zhou, Bo, Gu, Feng, Liu, Hongmei, Wu, Honglin, Yao, Fuwen, Zheng, Hui, Fu, Hui, Chong, Wei, Cai, Shurui, Huang, Min, Ma, Xiaolu, Guo, Zhifang, Li, Tingting, Deng, Wenyuan, Zheng, Meiwen, Ji, Qiao, Zhao, Yongliang, Ma, Yongjie, Wang, QiEn, Tang, TieShan, Guo, Caixia. Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation. MOLECULAR CELL[J]. 2022, 82(7): 1297-+, http://dx.doi.org/10.1016/j.molcel.2022.01.020.
[4] Chen, YuSheng, Lu, Shuaiyao, Zhang, Bing, Du, Tingfu, Li, WenJie, Lei, Meng, Zhou, Yanan, Zhang, Yong, Liu, Penghui, Sun, YongQiao, Zhao, YongLiang, Yang, Ying, Peng, Xiaozhong, Yang, YunGui. Comprehensive analysis of RNA-seq and whole genome sequencing data reveals no evidence for SARS-CoV-2 integrating into host genome. PROTEIN & CELL. 2022, 13(5): 379-385, http://dx.doi.org/10.1007/s13238-021-00861-8.
[5] Chen, YuSheng, Yang, WenLan, Zhao, YongLiang, Yang, YunGui. Dynamic transcriptomic m(5)C and its regulatory role in RNA processing. WILEY INTERDISCIPLINARY REVIEWS-RNAnull. 2021, 12(4): http://dx.doi.org/10.1002/wrna.1639.
[6] Tan, Qunsong, Niu, Kaifeng, Zhu, Yuqi, Chen, Zixiang, Li, Yueyang, Li, Mengge, Wei, Di, Balajee, Adayabalam S, Fang, Hongbo, Zhao, Yongliang. RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks. ONCOGENESIS[J]. 2021, 10(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935965/.
[7] Han, Xiao, Wang, Mengke, Zhao, YongLiang, Yang, Ying, Yang, YunGui. RNA methylations in human cancers. SEMINARS IN CANCER BIOLOGY[J]. 2021, 75: 97-115, http://dx.doi.org/10.1016/j.semcancer.2020.11.007.
[8] Shi, Boyang, Zhang, Jinsong, Heng, Jian, Gong, Jing, Zhang, Ting, Li, Pan, Sun, BaoFa, Yang, Ying, Zhang, Ning, Zhao, YongLiang, Wang, HaiLin, Liu, Feng, Zhang, Qiangfeng Cliff, Yang, YunGui. RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function. GENOME BIOLOGY[J]. 2020, 21(1): http://dx.doi.org/10.1186/s13059-020-02022-2.
[9] Zhao Yongliang. Deubiquitinate USP33 regulates Parkin and antagonizes its role in mitophagy. Autophagy. 2020, [10] Malbec, Lionel, Zhang, Ting, Chen, YuSheng, Zhang, Ying, Sun, BaoFa, Shi, BoYang, Zhao, YongLiang, Yang, Ying, Yang, YunGui. Dynamic methylome of internal mRNA N-7-methylguanosine and its regulatory role in translation. CELL RESEARCH[J]. 2019, 29(11): 927-941, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889513/.
[11] Fang, Hongbo, Niu, Kaifeng, Mo, Dongliang, Zhu, Yuqi, Tan, Qunsong, Wei, Di, Li, Yueyang, Chen, Zixiang, Yang, Shuchen, Balajee, Adayabalam S, Zhao, Yongliang. RecQL4-Aurora B kinase axis is essential for cellular proliferation, cell cycle progression, and mitotic integrity. ONCOGENESIS[J]. 2018, 7(9): https://doaj.org/article/2d6e822ed3e640f5b84703002e95a081.
[12] Wu, Rui, Tan, Qunsong, Niu, Kaifeng, Zhu, Yuqi, Wei, Di, Zhao, Yongliang, Fang, Hongbo. MMS19 localizes to mitochondria and protects the mitochondrial genome from oxidative damage. BIOCHEMISTRY AND CELL BIOLOGY[J]. 2018, 96(1): 44-49, https://www.webofscience.com/wos/woscc/full-record/WOS:000424445200007.
[13] Mo, Dongliang, Zhao, Yongliang, Balajee, Adayabalam S. Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells. CANCER LETTERSnull. 2018, 413: 1-10, http://dx.doi.org/10.1016/j.canlet.2017.10.021.
[14] Mo, Dongliang, Fang, Hongbo, Niu, Kaifeng, Liu, Jing, Wu, Meng, Li, Shiyou, Zhu, Tienian, Aleskandarany, Mohammed A, Arora, Arvind, Lobo, Dileep N, Madhusudan, Srinivasan, Balajee, Adayabalam S, Chi, Zhenfen, Zhao, Yongliang. Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway. CANCER RESEARCH[J]. 2016, 76(10): 3057-3066, https://www.webofscience.com/wos/woscc/full-record/WOS:000375841000023.
[15] Liu, Jing, Fang, Hongbo, Chi, Zhenfen, Wu, Zan, Wei, Di, Mo, Dongliang, Niu, Kaifeng, Balajee, Adayabalam S, Hei, Tom K, Nie, Linghu, Zhao, Yongliang. XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage. NUCLEIC ACIDS RESEARCH[J]. 2015, 43(11): 5476-5488, https://www.webofscience.com/wos/woscc/full-record/WOS:000357886900025.
[16] Fang Hongbo, Liu Jing, Guo Dan, Liu Peixiang, Zhao Yongliang. Epigenetic regulation of putative tumor suppressor TGFBI in human leukemias. CHINESE MEDICAL JOURNAL[J]. 2014, 127(9): 1645-1650, https://www.webofscience.com/wos/woscc/full-record/WOS:000335936800008.
[17] Fang, Hongbo, Nie, Linghu, Chi, Zhenfen, Liu, Jing, Guo, Dan, Lu, Xuemei, Hei, Tom K, Balajee, Adayabalam S, Zhao, Yongliang. RecQL4 Helicase Amplification Is Involved in Human Breast Tumorigenesis. PLOS ONE[J]. 2013, 8(7): https://doaj.org/article/dd06aefa62704f38a837eaf5f1054532.
[18] Chi, Zhenfen, Nie, Linghu, Peng, Zhao, Yang, Qiong, Yang, Kuan, Tao, Jiahai, Mi, Yang, Fang, Xiangdong, Balajee, Adayabalam S, Zhao, Yongliang. RecQL4 cytoplasmic localization: Implications in mitochondrial DNA oxidative damage repair. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY[J]. 2012, 44(11): 1942-1951, http://dx.doi.org/10.1016/j.biocel.2012.07.016.
[19] Su, Yanrong, Meador, Jarah A, Calaf, Gloria M, DeSantis, Luca Proietti, Zhao, Yongliang, Bohr, Vilhelm A, Balajee, Adayabalam S. Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis. CANCER RESEARCH[J]. 2010, 70(22): 9207-9217, https://www.webofscience.com/wos/woscc/full-record/WOS:000284213300026.
[20] Zhao Yongliang. TGFBI deficiency predispose mice to spontaneous tumor development. Cancer Research. 2009, [21] Jing Fu, Ju Zhang, Li Yang, Nan Ding, Liya Yue, Xiangli Zhang, Dandan Lu, Xinmiao Jia, Cuidan Li, Chongye Guo, Zhe Yin, Xiaoyuan Jiang, Yongliang Zhao, Fei Chen, Dongsheng Zhou. Precision Methylome and in vivo Methylation Kinetics Characterization of Klebsiella Pneumoniae. Genomics, Proteomics & Bioinformatics. http://dx.doi.org/10.1016/j.gpb.2021.04.002.
[22] Xiao Han, Jia Guo, Mengke Wang, Nan Zhang, Jie Ren, Ying Yang, Xu Chi, Yusheng Chen, Huan Yao, YongLiang Zhao, YunGui Yang, Yingpu Sun, Jiawei Xu. Dynamic DNA 5-hydroxylmethylcytosine and RNA 5-methycytosine Reprogramming During Early Human Development. Genomics, Proteomics & Bioinformatics. http://dx.doi.org/10.1016/j.gpb.2022.05.005.

   

（ 1 ） DNA修复相关蛋白的作用机制, 主持, 国家级, 2013-01--2017-08
（ 2 ） XPD蛋白参与DNA损伤响应调节的机制研究, 参与, 国家级, 2015-01--2019-08
（ 3 ） 着色性干皮病基因XPD及其相关蛋白参与线粒体DNA氧化损伤修复的分子机制, 主持, 国家级, 2016-01--2019-12
（ 4 ） 解旋酶RecQL4调控DNA双链断裂损伤修复通路选择的分子机制, 主持, 国家级, 2018-01--2021-12

（1）DNA损伤应答相关蛋白参与线粒体自稳态维持及肿瘤进展分子机制   “原创性科学研究”学术交流会   2016-10-12
（2）Human RecQL4 helicase drives cisplatin resistance in gastric cancer by activating an Akt-YB1-MDR1 pathway   亚洲冷泉港会议：DNA代谢，基因组稳定性与人类疾病   2016-06-13
（3）Human RecQ helicase in cellular immortalization and tumorigenicity   2013中美生命科学中心研讨会   2013-10-25
（4）Human helicase RecQL4 upregulation is involved in breast tumor progression and chemoresistance   第4届国际生物医学与环境健康前沿研讨会   2013-10-19
（5）RecQL4 cytoplasmic localization Implications in mitochondrial DNA oxidative damage repair   DNA损伤应答与人类疾病国际研讨会   Chi Zhenfen, Nie Linghu   2012-10-13

已指导学生

彭钊  硕士研究生  071022-基因组学  

陶佳海  硕士研究生  071007-遗传学  

池振奋  博士研究生  071007-遗传学  

陈苗  硕士研究生  071010-生物化学与分子生物学  

刘静  博士研究生  071010-生物化学与分子生物学  

吴赞  硕士研究生  071007-遗传学  

段仰苗  硕士研究生  071007-遗传学  

吴蕊  硕士研究生  071007-遗传学  

默董亮  博士研究生  071010-生物化学与分子生物学  

牛凯峰  博士研究生  071010-生物化学与分子生物学  

檀群松  博士研究生  071007-遗传学  

现指导学生

朱宇奇  博士研究生  071007-遗传学  

曹凤阳  硕士研究生  071007-遗传学  

李悦洋  博士研究生  071007-遗传学  

汪青  硕士研究生  071010-生物化学与分子生物学  

陈紫翔  博士研究生  071010-生物化学与分子生物学  

王梦柯  硕士研究生  0710J3-生物信息学  

张婉莹  硕士研究生  0710Z1-基因组学  

于悦  硕士研究生  071010-生物化学与分子生物学  

葛新阳  博士研究生  071010-生物化学与分子生物学  

李梦鸽  博士研究生  071010-生物化学与分子生物学