基本信息
李岩 女 硕导 生物物理研究所
电子邮件：yanli@ibp.ac.cn
通信地址：北京市朝阳区大屯路15号
邮政编码：100010
电子邮件：yanli@ibp.ac.cn
通信地址：北京市朝阳区大屯路15号
邮政编码：100010
研究领域
（1）开发以生物质谱为核心的多种蛋白质组学的分析技术和方法；
（2）发展适用于生物样品和临床样品的新型糖组学的分析技术和方法；
（3）在蛋白质组学和糖组学分析技术的基础上，主要开展针对蛋白质及其翻译后修饰的表达调控及其在人体功能和临床疾病中的作用机制的研究。
（2）发展适用于生物样品和临床样品的新型糖组学的分析技术和方法；
（3）在蛋白质组学和糖组学分析技术的基础上，主要开展针对蛋白质及其翻译后修饰的表达调控及其在人体功能和临床疾病中的作用机制的研究。
招生信息
招生专业
071010-生物化学与分子生物学
招生方向
应用生物质谱等分析技术研究糖组学及蛋白质组学的基础和临床问题
生物质谱技术
转化医学
生物质谱技术
转化医学
教育背景
2005-10--2011-06 美国约翰霍普金斯大学医学院 博士后
2000-09--2004-07 美国马里兰大学 博士
1994-09--1998-07 北京大学医学部（原北京医科大学） 学士
2000-09--2004-07 美国马里兰大学 博士
1994-09--1998-07 北京大学医学部（原北京医科大学） 学士
学历
博士研究生
学位
博士
工作经历
工作简历
2011-07--今 中国科学院生物物理研究所 研究员
2005-10--2011-06 美国约翰霍普金斯大学医学院 助理研究员/博士后
2004-01--2005-08 美国Calibrant生物技术公司 项目主管
2000-08--2004-05 美国马里兰大学化学与分析化学系 研究助理
2005-10--2011-06 美国约翰霍普金斯大学医学院 助理研究员/博士后
2004-01--2005-08 美国Calibrant生物技术公司 项目主管
2000-08--2004-05 美国马里兰大学化学与分析化学系 研究助理
专利与奖励
奖励信息
（1） Young Investigator Travel Award，一等奖，其他级，2010
（2） Outstanding Poster Award，一等奖，其他级，2009
（3） Young Investigator Travel Award，一等奖，其他级，2009
（2） Outstanding Poster Award，一等奖，其他级，2009
（3） Young Investigator Travel Award，一等奖，其他级，2009
专利成果
[1] 罗丹, 孙青, 卞铮, 张楚凡, 李岩. 一种用于人群调查的电子签章设备. CN: CN218032382U, 2022-12-13.
[2] 李岩, 罗丹, 孙青, 卞铮, 张楚凡. 一种用于人群调查的电子签章设备. 202222477244.1, 2022-05-20.
[3] 梁锴, 李岩, 赵克力, 孙青. 一种血液样本质量评估方法. CN: CN112745374A, 2021-05-04.
[4] 何建国, 黄纯翠, 貊泽强, 余锦, 李岩, 王金舵, 林蔚然, 刘洋, 刘昊. 一种微流控芯片的封接装置与封接方法. CN: CN106219482A, 2016-12-14.
[5] 孙世伟, 卜东波, 杨飞, 王耀军, 李岩, 黄纯翠, 陈润生, 高枫, 刘亚名. 一种糖结构鉴定方法及糖结构鉴定装置. CN: CN105758928A, 2016-07-13.
[6] 孙世伟, 卜东波, 杨飞, 王耀军, 李岩, 黄纯翠, 陈润生, 高枫, 刘亚名. 一种糖结构鉴定方法及糖结构鉴定装置. CN: CN105758928B, 2019-04-30.
[7] 李岩, 张建中, 李倩倩, 赵倩倩, 肖迪. 一种脂多糖中寡糖的纯化及质谱鉴定方法. CN: CN106932258A, 2017-07-07.
[8] 孙世伟, 王耀君, 卜东波, 李岩, 黄纯翠, 刘亚名, 杨飞, 武红梅, 陈润生. 多级质谱生物大分子结构鉴定方法. CN: CN104965020B, 2017-07-21.
[9] 孙世伟, 王耀君, 卜东波, 李岩, 黄纯翠, 刘亚名, 杨飞, 武红梅, 陈润生. 多级质谱生物大分子结构鉴定方法. CN: CN104965020A, 2015-10-07.
[10] 基于多级质谱技术鉴定糖链混合物的方法. 2023-09-27.
[11] 黄纯翠, 孙世伟, 侯梅洁, 王辉, 赵克力, 卜东波, 李岩. 基于多级质谱技术鉴定糖链混合物的方法. CN: CN117347466A, 2024-01-05.
[2] 李岩, 罗丹, 孙青, 卞铮, 张楚凡. 一种用于人群调查的电子签章设备. 202222477244.1, 2022-05-20.
[3] 梁锴, 李岩, 赵克力, 孙青. 一种血液样本质量评估方法. CN: CN112745374A, 2021-05-04.
[4] 何建国, 黄纯翠, 貊泽强, 余锦, 李岩, 王金舵, 林蔚然, 刘洋, 刘昊. 一种微流控芯片的封接装置与封接方法. CN: CN106219482A, 2016-12-14.
[5] 孙世伟, 卜东波, 杨飞, 王耀军, 李岩, 黄纯翠, 陈润生, 高枫, 刘亚名. 一种糖结构鉴定方法及糖结构鉴定装置. CN: CN105758928A, 2016-07-13.
[6] 孙世伟, 卜东波, 杨飞, 王耀军, 李岩, 黄纯翠, 陈润生, 高枫, 刘亚名. 一种糖结构鉴定方法及糖结构鉴定装置. CN: CN105758928B, 2019-04-30.
[7] 李岩, 张建中, 李倩倩, 赵倩倩, 肖迪. 一种脂多糖中寡糖的纯化及质谱鉴定方法. CN: CN106932258A, 2017-07-07.
[8] 孙世伟, 王耀君, 卜东波, 李岩, 黄纯翠, 刘亚名, 杨飞, 武红梅, 陈润生. 多级质谱生物大分子结构鉴定方法. CN: CN104965020B, 2017-07-21.
[9] 孙世伟, 王耀君, 卜东波, 李岩, 黄纯翠, 刘亚名, 杨飞, 武红梅, 陈润生. 多级质谱生物大分子结构鉴定方法. CN: CN104965020A, 2015-10-07.
[10] 基于多级质谱技术鉴定糖链混合物的方法. 2023-09-27.
[11] 黄纯翠, 孙世伟, 侯梅洁, 王辉, 赵克力, 卜东波, 李岩. 基于多级质谱技术鉴定糖链混合物的方法. CN: CN117347466A, 2024-01-05.
出版信息
发表论文
[1] Analytical and Bioanalytical Chemistry. 2025, 通讯作者
[2] 卞铮, 王翊涵, 鄢全意, 罗丹, 李岩. 大型队列研究数据资源的信息化建设. 中国科学. 生命科学[J]. 2024, 第 5 作者54(6): 1021-1028, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7775084&detailType=1.
[3] 孙青, 王宇, 阿尖措, 郝岩, 李岩. 脊椎动物体节形成的分节时钟调控机制. 生物化学与生物物理进展[J]. 2024, 第 5 作者51(4): 731-742, http://lib.cqvip.com/Qikan/Article/Detail?id=7111842549.
[4] Chuncui Huang, Yue Lu, Lin Kong, Zhendong Guo, Keli Zhao, Zheng Xiang, Xinyue Ma, Huanyu Gao, Yongfang Liu, Zhongmin Gao, Lijuan Xu, Wengang Chai, Yan Li, Yao Zhao. Human milk oligosaccharides in milk of mothers with term and preterm delivery at different lactation stage. CARBOHYDRATE POLYMERS[J]. 2023, 第 11 作者321: http://dx.doi.org/10.1016/j.carbpol.2023.121263.
[5] 马心悦, 黄纯翠, 赵耀, 李岩. ���������������������������������������. 生物化学与生物物理进展[J]. 2023, 第 11 作者
[6] chuncui huang, meijie hou, jingyu yan, Wengang Chai, Yan Li, Shiwei Sun. GIPS-Mix for Accurate Identification of Isomeric Components in Glycan Mixtures Using Intelligent Group-Opting Strategy. Analytical Chemistry[J]. 2023, 第 11 作者https://pubs.acs.org/doi/abs/10.1021/acs.analchem.2c02978.
[7] Liang Kai, Yan Li, Qianqian Li, Zhijing Song, keli zhao, Rong Su, Shengchun Huang, Xueyan Guo. Plasma Peptides Modulated by Protease in a Time-Dependent Manner as Effective Biomarkers for Preanalytical Quality Control. JOURNAL OF PROTEOME RESEARCH[J]. 2023, 第 2 作者
[8] Journal of Proteome Research. 2023, 通讯作者
[9] Chuncui Huang, Yue Lu, Lin Kong, Zhendong Guo, Keli Zhao, Zheng Xiang, Xinyue Ma, Huanyu Gao, Yongfang Liu, Zhongmin Gao, Lijuan Xu, Wengang Chai, Yan Li, Yao Zhao. Human milk oligosaccharides in milk of mothers with term and preterm delivery at different lactation stage. CARBOHYDRATE POLYMERS[J]. 2023, 第 13 作者 通讯作者 321: http://dx.doi.org/10.1016/j.carbpol.2023.121263.
[10] 马心悦, 黄纯翠, 赵耀, 李岩. 人乳寡糖的结构及其分离分析. 生物化学与生物物理进展[J]. 2023, 第 4 作者 通讯作者
[11] 李岩. Endogenous Plasma Peptides Modulated by Protease in a Time-Dependent Manner as Effective Biomarkers for Preanalytical Quality Control. Journal of Proteome Research[J]. 2023, 第 1 作者
[12] chuncui huang, meijie hou, jingyu yan, Wengang Chai, Yan Li, Shiwei Sun. GIPS-Mix for Accurate Identification of Isomeric Components in Glycan Mixtures Using Intelligent Group-Opting Strategy. Analytical Chemistry[J]. 2023, 第 5 作者 通讯作者 https://pubs.acs.org/doi/abs/10.1021/acs.analchem.2c02978.
[13] Wang, Junyan, Zhao, Keli, Chen, Ling, Zhou, Jinyu, Sun, Qing, Chen, Junhui, Su, Rong, Li, Yan. Proteomics and post-translational modifications analysis of umbilical mesenchymal stem cells aging. ANALYTICAL BIOCHEMISTRY[J]. 2022, 第 11 作者652: http://dx.doi.org/10.1016/j.ab.2022.114770.
[14] Zhang Q. Q, 李岩. MALDI���TOF���MS for Rapid Screening and Typing of ��-Globin Variant and ��-Thalassemia through Direct Measurements of Intact Globin Chains. Clinical Chemistry[J]. 2022, 第 2 作者
[15] Zou, Wenjun, Huang, Chuncui, Sun, Qing, Zhao, Keli, Gao, Huanyu, Su, Rong, Li, Yan. A stepwise mutagenesis approach using histidine and acidic amino acid to engineer highly pH-dependent protein switches. 3 BIOTECH[J]. 2022, 第 11 作者12(1): http://dx.doi.org/10.1007/s13205-021-03079-x.
[16] Wang, Junyan, Zhao, Keli, Chen, Ling, Zhou, Jinyu, Sun, Qing, Chen, Junhui, Su, Rong, Li, Yan. Proteomics and post-translational modifications analysis of umbilical mesenchymal stem cells aging. ANALYTICAL BIOCHEMISTRY[J]. 2022, 第 8 作者 通讯作者 652: http://dx.doi.org/10.1016/j.ab.2022.114770.
[17] 关丽芬, 王俊妍, 李炜煊, 黄纯翠, 李岩. 体外培养细胞系与体内血清蛋白质N糖基化的差异研究. 癌症进展[J]. 2022, 第 5 作者20(6): 561-564, http://lib.cqvip.com/Qikan/Article/Detail?id=7107110767.
[18] Zhang Q. Q, 李岩. MALDI–TOF–MS for Rapid Screening and Typing of β-Globin Variant and β-Thalassemia through Direct Measurements of Intact Globin Chains. Clinical Chemistry[J]. 2022, 第 2 作者
[19] Zou, Wenjun, Huang, Chuncui, Sun, Qing, Zhao, Keli, Gao, Huanyu, Su, Rong, Li, Yan. A stepwise mutagenesis approach using histidine and acidic amino acid to engineer highly pH-dependent protein switches. 3 BIOTECH[J]. 2022, 第 7 作者 通讯作者 12(1): http://dx.doi.org/10.1007/s13205-021-03079-x.
[20] Liu, Lu, Xie, Wenchun, Song, Zhijing, Wang, Tianyu, Li, Xuesong, Gao, Ying, Li, Yan, Zhang, Junqing, Guo, Xiaohui. Addition of 3-methoxytyramine or chromogranin A to plasma free metanephrines as the initial test for pheochromocytoma and paraganglioma: Which is the best diagnostic strategy. CLINICAL ENDOCRINOLOGY. 2021, 第 11 作者
[21] Huang, Chuncui, Tan, Zeshun, Zhao, Keli, Zou, Wenjun, Wang, Hui, Gao, Huanyu, Sun, Shiwei, Bu, Dongbo, Chai, Wengang, Li, Yan. The effect of N-glycosylation of SARS-CoV-2 spike protein on the virus interaction with the host cell ACE2 receptor. ISCIENCE[J]. 2021, 第 11 作者24(11): http://dx.doi.org/10.1016/j.isci.2021.103272.
[22] Wang, Junyan, Huang, Chuncui, Zhou, Jinyu, Zhao, Keli, Li, Yan. Causal link between immunoglobulin G glycosylation and cancer: A potential glycobiomarker for early tumor detection. CELLULAR IMMUNOLOGY. 2021, 第 11 作者361: http://dx.doi.org/10.1016/j.cellimm.2021.104282.
[23] Song, Zhijing, Gao, Huanyu, Xie, Wenchun, Sun, Qing, Liang, Kai, Li, Yan. Quantitative MALDI-MS assay of steroid hormones in plasma based on hydroxylamine derivatization. ANALYTICAL BIOCHEMISTRY[J]. 2021, 第 11 作者616: http://dx.doi.org/10.1016/j.ab.2020.114089.
[24] 孙青, 梁锴, 李岩. ���������������������������������������. 生物化学与生物物理进展[J]. 2021, 第 3 作者48(8): 938-946, http://lib.cqvip.com/Qikan/Article/Detail?id=7105583252.
[25] Sun Qing, Liang Kai, Li Yan. Quality Assessment for The Blood Samples. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2021, 第 11 作者48(8): 938-946, http://dx.doi.org/10.16476/j.pibb.2020.0375.
[26] Wang, Hui, Wang, Yu, Hou, Meijie, Zhang, Chunming, Wang, Yaojun, Guo, Zhendong, Bu, Dongbo, Li, Yan, Huang, Chuncui, Sun, Shiwei. HepParser: An Intelligent Software Program for Deciphering Low-Molecular-Weight Heparin Based on Mass Spectrometry. FRONTIERS IN CHEMISTRY[J]. 2021, 第 8 作者9: http://dx.doi.org/10.3389/fchem.2021.723149.
[27] Liu, Lu, Xie, Wenchun, Song, Zhijing, Wang, Tianyu, Li, Xuesong, Gao, Ying, Li, Yan, Zhang, Junqing, Guo, Xiaohui. Addition of 3-methoxytyramine or chromogranin A to plasma free metanephrines as the initial test for pheochromocytoma and paraganglioma: Which is the best diagnostic strategy. CLINICAL ENDOCRINOLOGY. 2021, 第 7 作者 通讯作者
[28] Huang, Chuncui, Tan, Zeshun, Zhao, Keli, Zou, Wenjun, Wang, Hui, Gao, Huanyu, Sun, Shiwei, Bu, Dongbo, Chai, Wengang, Li, Yan. The effect of N-glycosylation of SARS-CoV-2 spike protein on the virus interaction with the host cell ACE2 receptor. ISCIENCE[J]. 2021, 第 10 作者 通讯作者 24(11): http://dx.doi.org/10.1016/j.isci.2021.103272.
[29] Wang, Junyan, Huang, Chuncui, Zhou, Jinyu, Zhao, Keli, Li, Yan. Causal link between immunoglobulin G glycosylation and cancer: A potential glycobiomarker for early tumor detection. CELLULAR IMMUNOLOGY. 2021, 第 5 作者 通讯作者 361: http://dx.doi.org/10.1016/j.cellimm.2021.104282.
[30] Song, Zhijing, Gao, Huanyu, Xie, Wenchun, Sun, Qing, Liang, Kai, Li, Yan. Quantitative MALDI-MS assay of steroid hormones in plasma based on hydroxylamine derivatization. ANALYTICAL BIOCHEMISTRY[J]. 2021, 第 6 作者 通讯作者 616: http://dx.doi.org/10.1016/j.ab.2020.114089.
[31] 孙青, 梁锴, 李岩. 血液样本质量的评估技术进展. 生物化学与生物物理进展[J]. 2021, 第 3 作者48(8): 938-946, http://www.pibb.ac.cn/pibbcn/article/abstract/20200375?st=article_issue.
[32] Sun Qing, Liang Kai, Li Yan. Quality Assessment for The Blood Samples. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2021, 第 3 作者 通讯作者 48(8): 938-946, http://dx.doi.org/10.16476/j.pibb.2020.0375.
[33] Wang, Hui, Wang, Yu, Hou, Meijie, Zhang, Chunming, Wang, Yaojun, Guo, Zhendong, Bu, Dongbo, Li, Yan, Huang, Chuncui, Sun, Shiwei. HepParser: An Intelligent Software Program for Deciphering Low-Molecular-Weight Heparin Based on Mass Spectrometry. FRONTIERS IN CHEMISTRY[J]. 2021, 第 8 作者9: http://dx.doi.org/10.3389/fchem.2021.723149.
[34] Huang, Chuncui, Sun, Shiwei, Yan, Jingyu, Wang, Hui, Zhou, Jinyu, Gao, Huanyu, Xie, Wenchun, Li, Yan, Chai, Wengang. Identification of carbohydrate peripheral epitopes important for recognition by positive-ion MALDI multistage mass spectrometry. CARBOHYDRATE POLYMERS[J]. 2020, 第 11 作者229: http://dx.doi.org/10.1016/j.carbpol.2019.115528.
[35] 段云峰, 王升跃, 陈禹保, 杨瑞馥, 李后开, 朱怀球, 童贻刚, 杜文斌, 付钰, 胡松年, 王军, 辛玉华, 赵方庆, 鲍一明, 张雯, 李娟, 曾明, 牛海涛, 周欣, 李岩, 崔生辉, 袁静, 李俊桦, 王加义, 刘东来, 倪铭, 孙青, 邓晔, 朱宝利. ���������������������������������������. 生物工程学报[J]. 2020, 第 20 作者36(12): 2516-2524, http://lib.cqvip.com/Qikan/Article/Detail?id=7103610501.
[36] Zhou, Jinyu, Gao, Huanyu, Xie, Wenchun, Li, Yan. Bovine serum albumin affects N-glycoforms of murine IgG monoclonal antibody purified from hybridoma supernatants. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2020, 第 11 作者104(4): 1583-1594, https://www.webofscience.com/wos/woscc/full-record/WOS:000519153800016.
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[88] Zhou JinYu, Li QianQian, Huang ChunCui, Wu HongMei, Li Yan. Recent Advances in The Structural Analysis of Bacterial Lipopolysaccharide and Its Oligosaccharide Chains. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2017, 第 11 作者44(1): 49-57, https://www.webofscience.com/wos/woscc/full-record/WOS:000392575600007.
[89] Huang, Chuncui, Liu, Yaming, Wu, Hongmei, Sun, Dehui, Li, Yan. Characterization of IgG glycosylation in rheumatoid arthritis patients by MALDI-TOF-MSn and capillary electrophoresis. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2017, 第 11 作者409(15): 3731-3739, https://www.webofscience.com/wos/woscc/full-record/WOS:000401407900004.
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[98] 李岩. 细菌脂多糖及其寡糖链结构分析技术研究进展. 生物化学与生物物理进展. 2017, 第 1 作者 通讯作者
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[104] Huang, Chuncui, Liu, Yaming, Wu, Hongmei, Sun, Dehui, Li, Yan. Characterization of IgG glycosylation in rheumatoid arthritis patients by MALDI-TOF-MSn and capillary electrophoresis. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2017, 第 5 作者 通讯作者 409(15): 3731-3739, https://www.webofscience.com/wos/woscc/full-record/WOS:000401407900004.
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[117] Li, Yan, Shah, Punit, De Marzo, Angelo M, Van Eyk, Jennifer E, Lo, Qianqian, Chan, Daniel W, Zhang, Hui. Identification of Glycoproteins Containing Specific Glycans Using a Lectin-Chemical Method. ANALYTICAL CHEMISTRY[J]. 2015, 第 1 作者87(9): 4683-4687, https://www.webofscience.com/wos/woscc/full-record/WOS:000354153600016.
[118] Shanshan Yuan, Qianqian Li, Yang Zhang, Chuncui Huang, Hongmei Wu, Yan Li, Yalei Liu, Nan Yu, Hong Zhang, Guizhi Lu, Yanming Gao, Ying Gao, Xiaohui Guo. Changes in Anti-Thyroglobulin IgG Glycosylation Patterns in Hashimoto��s Thyroiditis Patients. THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2015, 第 6 作者100(2):
[119] Deng, Zaian, Li, Yaojun, Fan, Jia, Wang, Guohui, Li, Yan, Zhang, Yaou, Cai, Guoping, Shen, Haifa, Ferrari, Mauro, Hu, Tony Y. Circulating Peptidome to Indicate the Tumor-resident Proteolysis. SCIENTIFIC REPORTS[J]. 2015, 第 5 作者5: http://www.corc.org.cn/handle/1471x/2212512.
[120] 赵倩倩, 张自强, 李岩. ������������������������������������������������������������������. 中华检验医学杂志[J]. 2015, 第 3 作者38(2): 82-84, https://d.wanfangdata.com.cn/periodical/zhyxjy201502004.
[121] Huang, Chuncui, Zhan, Tiancheng, Liu, Yaming, Li, Qianqian, Wu, Hongmei, Ji, Dengbo, Li, Yan. Glycomic profiling of carcinoembryonic antigen isolated from human tumor tissue. CLINICAL PROTEOMICS[J]. 2015, 第 11 作者12(1): http://dx.doi.org/10.1186/s12014-015-9088-3.
[122] Li Yan. Identi���cation of Glycoproteins Containing Speci���c Glycans Using a Lectin-Chemical Method. Analytical Chemistry. 2015, 第 1 作者
[123] Yuan, Shanshan, Li, Qianqian, Zhang, Yang, Huang, Chuncui, Wu, Hongmei, Li, Yan, Liu, Yalei, Yu, Nan, Zhang, Hong, Lu, Guizhi, Gao, Yanming, Gao, Ying, Guo, Xiaohui. Changes in Anti-Thyroglobulin IgG Glycosylation Patterns in Hashimoto's Thyroiditis Patients. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM[J]. 2015, 第 6 作者100(2): 717-724, https://www.webofscience.com/wos/woscc/full-record/WOS:000353350900079.
[124] 张自强, 李岩. 质谱技术在临床生化检测中的应用. 检验医学[J]. 2015, 第 2 作者30(5): 407-409, http://lib.cqvip.com/Qikan/Article/Detail?id=664857665.
[125] Li, Yan, Shah, Punit, De Marzo, Angelo M, Van Eyk, Jennifer E, Lo, Qianqian, Chan, Daniel W, Zhang, Hui. Identification of Glycoproteins Containing Specific Glycans Using a Lectin-Chemical Method. ANALYTICAL CHEMISTRY[J]. 2015, 第 1 作者87(9): 4683-4687, https://www.webofscience.com/wos/woscc/full-record/WOS:000354153600016.
[126] Deng, Zaian, Li, Yaojun, Fan, Jia, Wang, Guohui, Li, Yan, Zhang, Yaou, Cai, Guoping, Shen, Haifa, Ferrari, Mauro, Hu, Tony Y. Circulating Peptidome to Indicate the Tumor-resident Proteolysis. SCIENTIFIC REPORTS[J]. 2015, 第 5 作者5: http://www.corc.org.cn/handle/1471x/2212512.
[127] Shanshan Yuan, Qianqian Li, Yang Zhang, Chuncui Huang, Hongmei Wu, Yan Li, Yalei Liu, Nan Yu, Hong Zhang, Guizhi Lu, Yanming Gao, Ying Gao, Xiaohui Guo. Changes in Anti-Thyroglobulin IgG Glycosylation Patterns in Hashimotoʼs Thyroiditis Patients. THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2015, 第 6 作者100(2):
[128] 赵倩倩, 张自强, 李岩. 质谱技术在肿瘤蛋白质标志物研究中的应用与发展. 中华检验医学杂志[J]. 2015, 第 3 作者38(2): 82-84, https://d.wanfangdata.com.cn/periodical/zhyxjy201502004.
[129] Huang, Chuncui, Zhan, Tiancheng, Liu, Yaming, Li, Qianqian, Wu, Hongmei, Ji, Dengbo, Li, Yan. Glycomic profiling of carcinoembryonic antigen isolated from human tumor tissue. CLINICAL PROTEOMICS[J]. 2015, 第 7 作者 通讯作者 12(1): http://dx.doi.org/10.1186/s12014-015-9088-3.
[130] Yuan, Shanshan, Li, Qianqian, Zhang, Yang, Huang, Chuncui, Wu, Hongmei, Li, Yan, Liu, Yalei, Yu, Nan, Zhang, Hong, Lu, Guizhi, Gao, Yanming, Gao, Ying, Guo, Xiaohui. Changes in Anti-Thyroglobulin IgG Glycosylation Patterns in Hashimoto's Thyroiditis Patients. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM[J]. 2015, 第 6 作者100(2): 717-724, https://www.webofscience.com/wos/woscc/full-record/WOS:000353350900079.
[131] Li Yan. Identification of Glycoproteins Containing Specific Glycans Using a Lectin-Chemical Method. Analytical Chemistry. 2015, 第 1 作者
[132] Yang, Shuang, Li, Yan, Shah, Punit, Zhang, Hui. Glycomic Analysis Using Glycoprotein Immobilization for Glycan Extraction. ANALYTICAL CHEMISTRY[J]. 2013, 第 2 作者85(11): 5555-5561, https://www.webofscience.com/wos/woscc/full-record/WOS:000320096900040.
[133] Yang, Shuang, Li, Yan, Shah, Punit, Zhang, Hui. Glycomic Analysis Using Glycoprotein Immobilization for Glycan Extraction. ANALYTICAL CHEMISTRY[J]. 2013, 第 2 作者85(11): 5555-5561, https://www.webofscience.com/wos/woscc/full-record/WOS:000320096900040.
[134] Prakash, Amol, Rezai, Taha, Krastins, Bryan, Sarracino, David, Athanas, Michael, Russo, Paul, Zhang, Hui, Tian, Yuan, Li, Yan, Kulasingam, Vathany, Drabovich, Andrei, Smith, Christopher R, Batruch, Ihor, Oran, Paul E, Fredolini, Claudia, Luchini, Alessandra, Liotta, Lance, Petricoin, Emanuel, Diamandis, Eleftherios P, Chan, Daniel W, Nelson, Randall, Lopez, Mary F. Interlaboratory Reproducibility of Selective Reaction Monitoring Assays Using Multiple Upfront Analyte Enrichment Strategies. JOURNAL OF PROTEOME RESEARCH[J]. 2012, 第 9 作者11(8): 3986-3995, https://www.webofscience.com/wos/woscc/full-record/WOS:000307037600006.
[135] Prakash, Amol, Rezai, Taha, Krastins, Bryan, Sarracino, David, Athanas, Michael, Russo, Paul, Zhang, Hui, Tian, Yuan, Li, Yan, Kulasingam, Vathany, Drabovich, Andrei, Smith, Christopher R, Batruch, Ihor, Oran, Paul E, Fredolini, Claudia, Luchini, Alessandra, Liotta, Lance, Petricoin, Emanuel, Diamandis, Eleftherios P, Chan, Daniel W, Nelson, Randall, Lopez, Mary F. Interlaboratory Reproducibility of Selective Reaction Monitoring Assays Using Multiple Upfront Analyte Enrichment Strategies. JOURNAL OF PROTEOME RESEARCH[J]. 2012, 第 9 作者11(8): 3986-3995, https://www.webofscience.com/wos/woscc/full-record/WOS:000307037600006.
[136] Li Yan. Simultaneous Analysis of Glycosylated and Sialylated PSA Reveals Differential Distribution of Glycosylation PSA Isoforms in Prostate Cancer Tissues. Analytical Chemistry. 2011, 第 1 作者
[137] Li, Yan, Tao, ShengCe, Bova, G Steven, Liu, Alvin Y, Chan, Daniel W, Zhu, Heng, Zhang, Hui. Detection and Verification of Glycosylation Patterns of Glycoproteins from Clinical Specimens Using Lectin Microarrays and Lectin-Based Immunosorbent Assays. ANALYTICAL CHEMISTRY[J]. 2011, 第 1 作者83(22): 8509-8516, https://www.webofscience.com/wos/woscc/full-record/WOS:000296830200022.
[138] Li, Yan. Identification of Glycosylation on Specific Glycosites using Lectin and Chemical Immobilizations and Mass Spectrometry. GLYCOBIOLOGY. 2011, 第 1 作者21(11): 1522-1523, https://www.webofscience.com/wos/woscc/full-record/WOS:000296045300220.
[139] Li Yan. Simultaneous Analysis of Glycosylated and Sialylated PSA Reveals Differential Distribution of Glycosylation PSA Isoforms in Prostate Cancer Tissues. Analytical Chemistry. 2011, 第 1 作者
[140] Li, Yan, Tao, ShengCe, Bova, G Steven, Liu, Alvin Y, Chan, Daniel W, Zhu, Heng, Zhang, Hui. Detection and Verification of Glycosylation Patterns of Glycoproteins from Clinical Specimens Using Lectin Microarrays and Lectin-Based Immunosorbent Assays. ANALYTICAL CHEMISTRY[J]. 2011, 第 1 作者83(22): 8509-8516, https://www.webofscience.com/wos/woscc/full-record/WOS:000296830200022.
[141] Li, Yan. Identification of Glycosylation on Specific Glycosites using Lectin and Chemical Immobilizations and Mass Spectrometry. GLYCOBIOLOGY. 2011, 第 1 作者21(11): 1522-1523, https://www.webofscience.com/wos/woscc/full-record/WOS:000296045300220.
[142] Li, Yan, Sokoll, Lori J, Rush, John, Meany, Danni, Zou, Nan, Chan, Daniel W, Zhang, Hui. Targeted detection of prostate cancer proteins in serum using heavy-isotope-labeled-peptide standards and MALDI-TOF/TOF. PROTEOMICS CLINICAL APPLICATIONS[J]. 2009, 第 1 作者3(5): 597-608, https://www.webofscience.com/wos/woscc/full-record/WOS:000266471400008.
[143] Li, Yan, Sokoll, Lori J, Rush, John, Meany, Danni, Zou, Nan, Chan, Daniel W, Zhang, Hui. Targeted detection of prostate cancer proteins in serum using heavy-isotope-labeled-peptide standards and MALDI-TOF/TOF. PROTEOMICS CLINICAL APPLICATIONS[J]. 2009, 第 1 作者3(5): 597-608, https://www.webofscience.com/wos/woscc/full-record/WOS:000266471400008.
[144] Yan Li, Lori J. Sokoll, Peter E. Barker, Hui Zhang, Daniel W. Chan. Mass Spectrometric Identification of Proteotypic Peptides from Clinically Used Tumor Markers. CLINICAL PROTEOMICS,. 2008, 第 1 作者4:
[145] Yan Li, Lori J. Sokoll, Peter E. Barker, Hui Zhang, Daniel W. Chan. Mass Spectrometric Identification of Proteotypic Peptides from Clinically Used Tumor Markers. CLINICAL PROTEOMICS,. 2008, 第 1 作者4:
[146] Li Yan. Microfluidics-Based Proteome Analysis. Proteomics for Biological Discovery. 2006, 第 1 作者
[147] Li Yan. Microfluidics-Based Proteome Analysis. Proteomics for Biological Discovery. 2006, 第 1 作者
[148] Li Yan. Integration of Isoelectric Focusing with Parallel SDS Gel Electrophoresis for Multidimensional Protein Separations in a Plastic Microfluidic Network. Analytical Chemistry. 2004, 第 1 作者
[149] Li Yan. Integration of Isoelectric Focusing with Parallel SDS Gel Electrophoresis for Multidimensional Protein Separations in a Plastic Microfluidic Network. Analytical Chemistry. 2004, 第 1 作者
[150] Fusong Ju, Jingwei Zhang, Dongbo Bu, Yan Li, Jinyu Zhou, Hui Wang, Yaojun Wang, Chuncui Huang, Shiwei Sun. De ovo glycan structural identification from mass spectra using tree merging strategy. COMPUTATIONAL BIOLOGY AND CHEMISTRY. 第 4 作者http://dx.doi.org/10.1016/j.compbiolchem.2019.03.015.
[151] Fusong Ju, Jingwei Zhang, Dongbo Bu, Yan Li, Jinyu Zhou, Hui Wang, Yaojun Wang, Chuncui Huang, Shiwei Sun. De ovo glycan structural identification from mass spectra using tree merging strategy. COMPUTATIONAL BIOLOGY AND CHEMISTRY. 第 4 作者http://dx.doi.org/10.1016/j.compbiolchem.2019.03.015.
科研活动
科研项目
（1） 人群样本库血液质量评估体系的建立与应用，主持，院级级，2015-07--2017-06
（2） 医学检测服务与技术研发，参与，院级级，2014-01--2015-12
（3） 代谢物组与非编码RNA的系统识别与鉴定关键技术研发，参与，国家级，2014-01--2016-12
（4） 中国人群前瞻性生物样本库建设，主持，院级级，2014-01--2017-12
（5） 胁迫环境中细胞代谢的调控机制，参与，国家级，2013-01--2017-12
（6） 可替代细菌血清学鉴定的高通量分子甄别技术的研发，参与，国家级，2013-01--2015-12
（7） 蛋白质糖基化修饰的高通量质谱检测技术，主持，国家级，2012-12--2016-12
（2） 医学检测服务与技术研发，参与，院级级，2014-01--2015-12
（3） 代谢物组与非编码RNA的系统识别与鉴定关键技术研发，参与，国家级，2014-01--2016-12
（4） 中国人群前瞻性生物样本库建设，主持，院级级，2014-01--2017-12
（5） 胁迫环境中细胞代谢的调控机制，参与，国家级，2013-01--2017-12
（6） 可替代细菌血清学鉴定的高通量分子甄别技术的研发，参与，国家级，2013-01--2015-12
（7） 蛋白质糖基化修饰的高通量质谱检测技术，主持，国家级，2012-12--2016-12
合作情况
项目协作单位
北京肿瘤医院：结直肠癌分子标志物的发现；
国家纳米科学中心：糖组学二维分析芯片及配套仪器的开发；
中国科学院光电研究院、北京国科世纪激光技术有限公司：病理诊断新型仪器开发。
国家纳米科学中心：糖组学二维分析芯片及配套仪器的开发；
中国科学院光电研究院、北京国科世纪激光技术有限公司：病理诊断新型仪器开发。
个人主页
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