代谢组学和微生物组学结合免疫学研究肥胖和癌症等代谢性疾病以及衰老和骨质疏松等退行性病变的分子机制。

中药药效物质基础的多组学筛选和评价及其对代谢性疾病或退行性病变的防治。

招收分析化学、生命科学、中药学等专业领域的研究生

070302-分析化学

色谱质谱分析、核磁共振分析
生物学、分析化学
中药学、微生物学

2002-09--2007-06   中科院武汉物理与数学研究所   理学博士学位
1995-09--1999-07   华中师范大学   学士学位

   

2016-10~现在, 中科院武汉物理与数学研究所, 研究员，磁共振应用部副主任，生物医学代谢组学研究组组长
2012-02~2016-02,美国宾夕法尼亚州州立大学, Research fellow
2010-10~2016-10,中科院武汉物理与数学研究所, 副研究员
2007-07~2010-10,中科院武汉物理与数学研究所, 助理研究员
1999-07~2002-09,湖北省宜昌市第一中学, 中级化学教师

2018-12-30-2021-11-29,华中科技大学, 教授
2018-01-01-2019-12-31,《波谱学杂志》青年编委,

磁共振前沿讲座

   

（1） 中国科学院武汉分院优秀研究生指导教师, 院级, 2020
（2） 武汉市“3551”创新人才, 市地级, 2017
（3） 年度考核优秀, 研究所（学校）, 2016
（4） 年度考核优秀, , 研究所（学校）, 2011
（5） 年度考核优秀, , 研究所（学校）, 2010
（6） 年度考核优秀, , 研究所（学校）, 2009
（7） 优秀青年教师, 一等奖, 市地级, 2002
（8） 优秀青年教师, 一等奖, 市地级, 2001

（ 1 ） 纳米技术 纳米生物效应代谢组学方法 核磁共振波谱法, 实用新型, 2017, 第 1 作者, 专利号: GB/T-34059-2017

   

[1] Ce Zhang, Zunji Shi, Hehua Lei, Fang Wu, Chuan Chen, Zheng Cao, Yuchen Song, Cui Zhang, Limin Zhang. Dietary Isoquercetin Reduces Hepatic Cholesterol and Triglyceride in NAFLD Mice by Modulating Bile Acid Metabolism via Intestinal FXR-FGF15 Signaling. J. Agric. Food Chem.[J]. 2023, 71: 7723-7733, [2] Shi, Zunji, Zhang, Ce, Lei, Hehua, Chen, Chuan, Cao, Zheng, Song, Yuchen, Chen, Gui, Wu, Fang, Zhou, Jinlin, Lu, Yujing, Zhang, Limin. Structural Insights into Amelioration Effects of Quercetin and Its Glycoside Derivatives on NAFLD in Mice by Modulating the Gut Microbiota and Host Metabolism. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2022, 70(46): 14732-14743, http://dx.doi.org/10.1021/acs.jafc.2c06212.
[3] Su, Henghai, Yuan, Peihong, Lei, Hehua, Zhang, Li, Deng, Dazhi, Zhang, Limin, Chen, Xiaoyu. Long-term chronic exposure to di-(2-ethylhexyl)-phthalate induces obesity via disruption of host lipid metabolism and gut microbiota in mice. CHEMOSPHERE[J]. 2022, 287: http://dx.doi.org/10.1016/j.chemosphere.2021.132414.
[4] Song, Yuchen, Zhang, Cui, Lei, Hehua, Qin, Mengyu, Chen, Gui, Wu, Fang, Chen, Chuan, Cao, Zheng, Zhang, Ce, Wu, Mengjing, Chen, Xiaoyu, Zhang, Limin. Characterization of triclosan-induced hepatotoxicity and triclocarban- triggered enterotoxicity in mice by multiple omics screening. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2022, 838: http://dx.doi.org/10.1016/j.scitotenv.2022.156570.
[5] Wu, Fang, Lei, Hehua, Chen, Gui, Chen, Chuan, Song, Yuchen, Cao, Zheng, Zhang, Ce, Zhang, Cui, Zhou, Jinlin, Lu, Yujing, Zhang, Limin. Multiomics Analyses Reveal That Long-Term Intake of Hesperetin-7-O-glucoside Modulates the Gut Microbiota and Bile Acid Metabolism in Mice. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2022, 70(47): 14831-14840, http://dx.doi.org/10.1021/acs.jafc.2c05053.
[6] Chen, Gui, Huang, Jiajun, Lei, Hehua, Wu, Fang, Chen, Chuan, Song, Yuchen, Cao, Zheng, Zhang, Ce, Zhang, Cui, Ma, Yuxi, Huang, Mingtao, Zhou, Jinlin, Lu, Yujing, Zhao, Yanxia, Zhang, Limin. Icariside I - A novel inhibitor of the kynurenine-AhR pathway with potential for cancer therapy by blocking tumor immune escape. BIOMEDICINE & PHARMACOTHERAPY[J]. 2022, 153: https://doaj.org/article/a461312a0457479da0f82d5ee076bb57.
[7] Zhang, HuaBao, Cao, Zheng, Qiao, JunXue, Zhong, ZiQian, Pan, ChenChen, Liu, Chen, Zhang, LiMin, Wang, YuFeng. Metabolomics provide new insights into mechanisms of Wolbachia-induced paternal defects in Drosophila melanogaster. PLOS PATHOGENS[J]. 2021, 17(8): https://doaj.org/article/8030b88e0d2e4801a076112aac389027.
[8] Zunji Shi, Hehua Lei, Gui Chen, Peihong Yuan, Zheng Cao, HooiLeng Ser, Xuehang Zhu, Fang Wu, Caixiang Liu, Manyuan Dong, Yuchen Song, Yangyang Guo, Chuan Chen, Kexin Hu, Yifan Zhu, Xinan Zeng, Jinlin Zhou, Yujing Lu, Andrew D Patterson, Limin Zhang. Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice. MSYSTEMS[J]. 2021, 6(1): https://doaj.org/article/dad310dbc35846e993460fb9a4563b07.
[9] Zhang Limin. Comparison of Metabolic Profiling of Arabidopsis Inflorescences Between Landsberg erecta and Columbia, and Meiosis‑Defective Mutants by 1H‑NMR Spectroscopy. Phenomics. 2021, [10] Lei, Hehua, Song, Yuchen, Dong, Manyuan, Chen, Gui, Cao, Zheng, Wu, Fang, Chen, Chuan, Zhang, Ce, Liu, Caixiang, Shi, Zunji, Zhang, Limin. Metabolomics safety assessments of microcystin exposure via drinking water in rats. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2021, 212: http://dx.doi.org/10.1016/j.ecoenv.2021.111989.
[11] Shi, Zunji, Chen, Gui, Cao, Zheng, Wu, Fang, Lei, Hehua, Chen, Chuan, Song, Yuchen, Liu, Caixiang, Li, Jinquan, Zhou, Jinlin, Lu, Yujing, Zhang, Limin. Gut Microbiota and Its Metabolite Deoxycholic Acid Contribute to Sucralose Consumption-Induced Nonalcoholic Fatty Liver Disease. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2021, 69(13): 3982-3991, http://dx.doi.org/10.1021/acs.jafc.0c07467.
[12] Liu, Qing, Zhang, Limin, Allman, Erik L, Hubbard, Troy D, Murray, Iain A, Hao, Fuhua, Tian, Yuan, Gui, Wei, Nichols, Robert G, Smith, Philip B, Anitha, Mallappa, Perdew, Gary H, Patterson, Andrew D. The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis. TOXICOLOGY[J]. 2021, 458: http://dx.doi.org/10.1016/j.tox.2021.152831.
[13] Chen, Gui, Cao, Zheng, Shi, Zunji, Lei, Hehua, Chen, Chuan, Yuan, Peihong, Wu, Fang, Liu, Caixiang, Dong, Manyuan, Song, Yuchen, Zhou, Jinlin, Lu, Yujing, Zhang, Limin. Microbiome analysis combined with targeted metabolomics reveal immunological anti-tumor activity of icariside I in a melanoma mouse model. BIOMEDICINE & PHARMACOTHERAPY[J]. 2021, 140: http://dx.doi.org/10.1016/j.biopha.2021.111542.
[14] Shi, Zunji, Qi, Xiaoli, Zeng, Xinan, Lu, Yujing, Zhou, Jinlin, Cui, Kehui, Zhang, Limin. A newly isolated bacterium Comamonas sp. XL8 alleviates the toxicity of cadmium exposure in rice seedlings by accumulating cadmium. JOURNAL OF HAZARDOUS MATERIALS[J]. 2021, 403: http://dx.doi.org/10.1016/j.jhazmat.2020.123824.
[15] Manyuan Dong, Peihong Yuan, Yuchen Song, Hehua Lei, Gui Chen, Xuehang Zhu, Fang Wu, Chuan Chen, Caixiang Liu, Zunji Shi, Limin Zhang. In vitro effects of Triclocarban on adipogenesis in murine preadipocyte and human hepatocyte. JOURNAL OF HAZARDOUS MATERIALS. 2020, 399: [16] Yuan, Peihong, Dong, Manyuan, Lei, Hehua, Xu, Guangyong, Chen, Gui, Song, Yuchen, Ma, Jianfeng, Cheng, Liming, Zhang, Limin. Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice. ENVIRONMENTAL POLLUTION[J]. 2020, 259: http://dx.doi.org/10.1016/j.envpol.2019.113820.
[17] Zhang, Limin, Rimal, Bipin, Nichols, Robert G, Tian, Yuan, Smith, Philip B, Hatzakis, Emmanuel, Chang, ShuChing, Butenhoff, John L, Peters, Jeffrey M, Patterson, Andrew D. Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice. TOXICOLOGY[J]. 2020, 431: 152365-152365, http://dx.doi.org/10.1016/j.tox.2020.152365.
[18] Wang, Tongtong, Liu, Quanhui, Wang, Min, Zhou, Jian, Yang, Mengrui, Chen, Gui, Tang, Fenfen, Hatzakis, Emmanuel, Zhang, Limin. Quantitative Measurement of a Chiral Drug in a Complex Matrix: A J-Compensated Quantitative HSQC NMR Method. ANALYTICAL CHEMISTRY[J]. 2020, 92(5): 3636-3642, https://www.webofscience.com/wos/woscc/full-record/WOS:000518234700022.
[19] 张利民, Fang Wu, Zunji Shi, Hehua Lei, Gui Chen, Peihong Yuan, Zheng Cao, Chuan Chen, Xuehang Zhu, Caixiang Liu, Manyuan Dong, Yuchen Song, Yangyang Guo, Jinlin Zhou, Yujing Lu, and Limin Zhang. Short-Term Intake of Hesperetin-7‑O‑Glucoside Affects Fecal Microbiota and Host Metabolic Homeostasis in Mice. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2020, 69: 1478-1486, [20] Dong, Manyuan, Xu, Xiaoyi, Huang, Qingxia, Lei, Hehua, Xu, Guangyong, Ma, Jianfeng, Hatzakis, Emmanuel, Wang, Xian, Zhang, Limin. Dose-Dependent Effects of Triclocarban Exposure on Lipid Homeostasis in Rats. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2019, 32(11): 2320-2328, https://www.webofscience.com/wos/woscc/full-record/WOS:000498282300016.
[21] Chen, Fengming, Coslo, Denise M, Chen, Tao, Zhang, Limin, Tian, Yuan, Smith, Philip B, Patterson, Andrew D, Omiecinski, Curtis J. Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism. JOURNAL OF PROTEOME RESEARCH[J]. 2019, 18(1): 239-251, https://www.webofscience.com/wos/woscc/full-record/WOS:000455285900021.
[22] Belton, Kerry R, Tian, Yuan, Zhang, Limin, Anitha, Mallappa, Smith, Philip B, Perdew, Gary H, Patterson, Andrew D. Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice. JOURNAL OF PROTEOME RESEARCH[J]. 2018, 17(4): 1375-1382, [23] Cai, Jingwei, Nichols, Robert G, Koo, Imhoi, Kalikow, Zachary A, Zhang, Limin, Tian, Yuan, Zhang, Jingtao, Smith, Philip B, Patterson, Andrew D. Multiplatform Physiologic and Metabolic Phenotyping Reveals Microbial Toxicity. MSYSTEMS[J]. 2018, 3(6): http://202.127.146.157/handle/2RYDP1HH/6252.
[24] Zhang, Limin, Tian, Yuan, Yang, Jianfen, Li, Jieshou, Tang, Huiru, Wang, Yulan. Colon Ascendens Stent Peritonitis (CASP) Induces Excessive Inflammation and Systemic Metabolic Dysfunction in a Septic Rat Model. JOURNAL OF PROTEOME RESEARCH[J]. 2018, 17(1): 680-688, https://www.webofscience.com/wos/woscc/full-record/WOS:000419749800061.
[25] Singh, Vishal, Yeoh, Beng San, Chassaing, Benoit, Xiao, Xia, Saha, Piu, Olvera, Rodrigo Aguilera, Lapek, John D, Jr, Zhang, Limin, Wang, WeiBei, Hao, Sijie, Flythe, Michael D, Gonzalez, David J, Cani, Patrice D, ConejoGarcia, Jose R, Xiong, Na, Kennett, Mary J, Joe, Bina, Patterson, Andrew D, Gewirtz, Andrew T, VijayKumar, Matam. Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer. CELL[J]. 2018, 175(3): 679-+, http://dx.doi.org/10.1016/j.cell.2018.09.004.
[26] L Zhang. Metabolomics reveals that dietary ferulic acid and quercetin modulate metabolic homeostasis in rats. INFORM. 2018, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SPQDAB613E166CE41131126310E20587C4D0&DbName=SPQDLAST&DbCode=SPQD&yx=&pr=&URLID=&bsm=.
[27] Limin Zhang, Robert G. Nichols, Andrew D. Patterson. The aryl hydrocarbon receptor as a moderator of host-microbiota communication. CURRENTOPINIONINTOXICOLOGY[J]. 2017, 30-35, http://dx.doi.org/10.1016/j.cotox.2017.02.001.
[28] Deng, Dazhi, Jian, Chongdong, Lei, Ling, Zhou, Yijing, McSweeney, Colleen, Dong, Fengping, Shen, Yilun, Zou, Donghua, Wang, Yonggang, Wu, Yuan, Zhang, Limin, Mao, Yingwei. A prenatal interruption of DISC1 function in the brain exhibits a lasting impact on adult behaviors, brain metabolism, and interneuron development. ONCOTARGET[J]. 2017, 8(49): 84798-84817, https://www.webofscience.com/wos/woscc/full-record/WOS:000413077800029.
[29] Hu, Yili, Zhang, Limin, Wang, Hai, Xu, Shan, Mujeeb, Ayeesha, Nie, Guangjun, Tang, Huiru, Wang, Yulan. Biological effects of amphiphilic copolymer nanoparticle-encapsulated multi- target chemotherapeutic drugs on MCF-7 human breast cancer cells. METABOLOMICS[J]. 2017, 13(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000399681400004.
[30] Jingwei Cai, Jingtao Zhang, Yuan Tian, Limin Zhang, Emmanuel Hatzakis, Kristopher W Krausz, Philip B Smith, Frank J Gonzalez, Andrew D Patterson. Orthogonal Comparison of GC−MS and 1 H NMR Spectroscopy for Short Chain Fatty Acid Quantitation. ANALYTICAL CHEMISTRY. 2017, 89(15): 7900-7906, [31] Soo, Valerie W C, McAnulty, Michael J, Tripathi, Arti, Zhu, Fayin, Zhang, Limin, Hatzakis, Emmanuel, Smith, Philip B, Agrawal, Saumya, NazemBokaee, Hadi, Gopalakrishnan, Saratram, Salis, Howard M, Ferry, James G, Maranas, Costas D, Patterson, Andrew D, Wood, Thomas K. Reversing methanogenesis to capture methane for liquid biofuel precursors. MICROBIAL CELL FACTORIES[J]. 2016, 15(1): http://ir.wipm.ac.cn/handle/112942/9146.
[32] Limin Zhang, Emmanuel Hatzakis, Andrew D. Patterson. NMR-Based Metabolomics and Its Application in Drug Metabolism and Cancer Research. CURRENT PHARMACOLOGY REPORTS,. 2016, 2(5): [33] Zhang Limin. The Aryl Hydrocarbon Receptor as a Modulator of Host-MicrobiotaInteraction. Current Opinion Toxicology. 2016, [34] Murray, Iain A, Nichols, Robert G, Zhang, Limin, Patterson, Andrew D, Perdew, Gary H. Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000384065500001.
[35] Limin Zhang, Cen Xie, Robert G Nichols, Siu H J Chan, Changtao Jiang, Ruixin Hao, Philip B Smith, Jingwei Cai, Margaret N Simons, Emmanuel Hatzakis, Costas D Maranas, Frank J Gonzalez, Andrew D Patterson. Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism. MSYSTEMS[J]. 2016, 1(5): https://doaj.org/article/d6d456289c6c4af3a8960c2110a98e67.
[36] Kumar, Yashwant, Zhang, Limin, Panigrahi, Priyabrata, Dholakia, Bhushan B, Dewangan, Veena, Chavan, Sachin G, Kunjir, Shrikant M, Wu, Xiangyu, Li, Ning, Rajmohanan, Pattuparambil R, Kadoo, Narendra Y, Giri, Ashok P, Tang, Huiru, Gupta, Vidya S. Fusarium oxysporum mediates systems metabolic reprogramming of chickpea roots as revealed by a combination of proteomics and metabolomics. PLANT BIOTECHNOLOGY JOURNAL[J]. 2016, 14(7): 1589-1603, http://dx.doi.org/10.1111/pbi.12522.
[37] Zhang Limin. Perfluorooctane Sulfonate-Choline Ion Pair Formation:A Potential Mechanism Modulating Hepatic Steatosisand Oxidative Stress in Mice. Toxiciology Sciences. 2016, [38] Cai, Jingwei, Zhang, Limin, Jones, Richard A, Correll, Jared B, Hatzakis, Emmanuel, Smith, Philip B, Gonzalez, Frank J, Patterson, Andrew D. Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota. JOURNAL OF PROTEOME RESEARCH[J]. 2016, 15(2): 563-571, http://dx.doi.org/10.1021/acs.jproteome.5b00957.
[39] Singh, Vishal, Chassaing, Benoit, Zhang, Limin, Yeoh, Beng San, Xiao, Xia, Kumar, Manish, Baker, Mark T, Cai, Jingwei, Walker, Rachel, Borkowski, Kamil, Harvatine, Kevin J, Singh, Nagendra, Shearer, Gregory C, Ntambi, James M, Joe, Bina, Patterson, Andrew D, Gewirtz, Andrew T, VijayKumar, Matam. Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice. CELL METABOLISM[J]. 2015, 22(6): 983-996, http://dx.doi.org/10.1016/j.cmet.2015.09.028.
[40] Zhang, Limin, Hatzakis, Emmanuel, Nichols, Robert G, Hao, Ruixin, Correll, Jared, Smith, Philip B, Chiaro, Christopher R, Perdew, Gary H, Patterson, Andrew D. Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2015, 49(13): 8067-8077, https://www.webofscience.com/wos/woscc/full-record/WOS:000357840300069.
[41] Zhang, Limin, Nichols, Robert G, Correll, Jared, Murray, Iain A, Tanaka, Naoki, Smith, Philip B, Hubbard, Troy D, Sebastian, Aswathy, Albert, Istvan, Hatzakis, Emmanuel, Gonzalez, Frank J, Perdew, Gary H, Patterson, Andrew D. Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation. ENVIRONMENTAL HEALTH PERSPECTIVES[J]. 2015, 123(7): 679-688, http://ir.wipm.ac.cn/handle/112942/4866.
[42] Zhang Limin. Quantitative Analysis of Purine Nucleotides Reveals Purinosomes Increase de Novo Purine Biosynthesis. Journal of Biological Chemistry. 2015, [43] Jiang, Changtao, Xie, Cen, Li, Fei, Zhang, Limin, Nichols, Robert G, Krausz, Kristopher W, Cai, Jingwei, Qi, Yunpeng, Fang, ZhongZe, Takahashi, Shogo, Tanaka, Naold, Desai, Dhimant, Amin, Shantu G, Albert, Istvan, Patterson, Andrew D, Gonzalez, Frank J. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. JOURNAL OF CLINICAL INVESTIGATION[J]. 2015, 125(1): 386-402, http://ir.iphy.ac.cn/handle/311004/60758.
[44] Zhang, Limin, Wang, Yulan, Xu, Yunxiang, Lei, Hehua, Zhao, Ying, Li, Huihui, Lin, Xiaosheng, Chen, Guizhen, Tang, Huiru. Metabonomic Analysis Reveals Efficient Ameliorating Effects of Acupoint Stimulations on the Menopause-caused Alterations in Mammalian Metabolism. SCIENTIFIC REPORTS[J]. 2014, 4: http://dx.doi.org/10.1038/srep03641.
[45] Ding, Lijian, Chen, Juanjuan, Zou, Jianding, Zhang, Limin, Ye, Yangfang. Dynamic metabolomic responses of Escherichia coli to nicotine stress. CANADIAN JOURNAL OF MICROBIOLOGY[J]. 2014, 60(8): 547-556, http://ir.wipm.ac.cn/handle/112942/1352.
[46] Huang, Lin, Chen, Xiuli, Thanh Xuan Nguyen, Tang, Huiru, Zhang, Liming, Yang, Guang. Nano-cellulose 3D-networks as controlled-release drug carriers. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2013, 1(23): 2976-2984, http://ir.wipm.ac.cn/handle/112942/849.
[47] An, Yanpeng, Xu, Wenxin, Li, Huihui, Lei, Hehua, Zhang, Limin, Hao, Fuhua, Duan, Yixuan, Yan, Xing, Zhao, Ying, Wu, Junfang, Wang, Yulan, Tang, Huiru. High-Fat Diet Induces Dynamic Metabolic Alterations in Multiple Biological Matrices of Rats. JOURNAL OF PROTEOME RESEARCH[J]. 2013, 12(8): 3755-3768, http://dx.doi.org/10.1021/pr400398b.
[48] Li, Huihui, An, Yanpeng, Zhang, Lulu, Lei, Hehua, Zhang, Limin, Wang, Yulan, Tang, Huiru. Combined NMR and GC-MS Analyses Revealed Dynamic Metabolic Changes Associated with the Carrageenan-Induced Rat Pleurisy. JOURNAL OF PROTEOME RESEARCH[J]. 2013, 12(12): 5520-5534, http://dx.doi.org/10.1021/pr400440d.
[49] 赵宇亮. Selective metabolic effects of gold nanorods on normal and cancer cells and their application in anticancer drug screening. BIOMATERIALS[J]. 2013, 34(29): 7117-7126, http://dx.doi.org/10.1016/j.biomaterials.2013.05.043.
[50] Wang, Yihuang, Zhang, Limin, Chen, WenLian, Wang, JingHan, Li, Ning, Li, JunMin, Mi, JianQing, Zhang, WeiNa, Li, Yang, Wu, SongFang, Jin, Jie, Wang, YunGui, Huang, He, Chen, Zhu, Chen, SaiJuan, Tang, Huiru. Rapid Diagnosis and Prognosis of de novo Acute Myeloid Leukemia by Serum Metabonomic Analysis. JOURNAL OF PROTEOME RESEARCH[J]. 2013, 12(10): 4393-4401, http://dx.doi.org/10.1021/pr400403p.
[51] Ye, Yangfang, Zhang, Limin, Yang, Rui, Luo, Qijun, Chen, Haimin, Yan, Xiaojun, Tang, Huiru. Metabolic Phenotypes Associated with High-Temperature Tolerance of Porphyra haitanensis Strains. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2013, 61(35): 8356-8363, http://dx.doi.org/10.1021/jf402749a.
[52] Zhang Limin. Global metabolomic responses of E. coli HB101 to heat stress. J. Proteome Res.. 2012, [53] Huang, Jing, Jiang, Limiao, Ren, Pingping, Zhang, Limin, Tang, Huiru. Comprehensive Solid-State NMR Analysis Reveals the Effects of N-Methylation on the Molecular Dynamics of Glycine. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2012, 116(1): 136-146, http://dx.doi.org/10.1021/jp2104374.
[54] Yangfang Ye, Xin Wang, Limin Zhang, Zhenmei Lu, Xiaojun Yan. Unraveling the concentration-dependent metabolic response of Pseudomonas sp. HF-1 to nicotine stress by 1 H NMR-based metabolomics. ECOTOXICOLOGY,. 2012, 21(5): [55] Tian, Yuan, Zhang, Limin, Wang, Yulan, Tang, Huiru. Age-Related Topographical Metabolic Signatures for the Rat Gastrointestinal Contents. JOURNAL OF PROTEOME RESEARCH[J]. 2012, 11(2): 1397-1411, http://dx.doi.org/10.1021/pr2011507.
[56] Zhang Limin. Systems Biological Responses of Rats to Aflatoxin B1 Exposure Revealed by Metabonomic NMR Analysis. J. Proteome Res.. 2011, [57] Hao Fuhua. NMR analysis of metabolite composition of Escherichia coli. Chin. J. Anal. Chem. 2011, [58] Ren, Pingping, Reichert, Detlef, He, Qinghua, Zhang, Limin, Tang, Huiru. Understanding the Molecular Dynamics Associated with Polymorphic Transitions of DL-Norvaline with Solid-State NMR Methods. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2011, 115(12): 2814-2823, http://www.irgrid.ac.cn/handle/1471x/960277.
[59] Zou, Qin, Zhang, Limin, Li, Shenhui, Gao, Xiuzhi, Deng, Feng. A solid-state NMR study of structure and segmental dynamics of poly(propylmethacryl-heptaisobutyl-pss)-co-styrene nanocomposites. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2011, 355(2): 334-341, http://dx.doi.org/10.1016/j.jcis.2010.12.044.
[60] Zhang Limin. Beyond the T1 limit: Quantitative measure- ment in solid state NMR. Journal of the American Chemical Society. 2010, [61] Feng, Jianghua, Liu, Huili, Zhang, Limin, Bhakoo, Kishore, Lu, Lehui. An insight into the metabolic responses of ultra-small superparamagnetic particles of iron oxide using metabonomic analysis of biofluids. NANOTECHNOLOGY[J]. 2010, 21(39): http://www.irgrid.ac.cn/handle/1471x/960487.
[62] Zhang, Limin, Xu, Jun, Hou, Guangjin, Tang, Huiru, Deng, Feng. Interactions between Nafion resin and protonated dodecylamine modified montmorillonite: A solid state NMR study. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2007, 311(1): 38-44, http://dx.doi.org/10.1016/j.jcis.2007.02.052.
[63] Zhang Limin. Solid State NMR Studies of the Structure and Mobility of Semi-crystalline Poly(3-hydroxybutyrate) and Poly(3-hydroxybutyrate-co-3-hydroxyvalerate). polymer. 2007, 

   

（ 1 ） 典型代谢物分子动力学与结构依赖性的固体NMR研究, 主持, 国家级, 2010-01--2013-06
（ 2 ） 黄曲霉毒素毒性和致病机理及药物的预防作用, 主持, 部委级, 2008-01--2010-01
（ 3 ） 有害物质引发动物应答的代谢组变化研究, 参与, 国家级, 2009-01--2013-12
（ 4 ） 转基因小麦快速甄别与检测技术, 参与, 国家级, 2009-06--2011-12
（ 5 ） 花生四烯酸及代谢组学研究, 参与, 国家级, 2010-01--2014-12
（ 6 ） 基于宿主代谢和肠道菌群变化研究四氯二苯并呋喃诱导肥胖发生的分子机理, 主持, 国家级, 2016-01--2019-12
（ 7 ） 基于质谱探针技术的模型鼠粪便代谢物全分析方法学研究, 参与, 国家级, 2017-01--2021-12
（ 8 ） 基于宿主代谢和肠道菌群调节研究多环芳烃核受体AHR抑制改善肥胖的分子机理, 主持, 省级, 2017-01--2018-12
（ 9 ） 特定位点同位素的食品真实性鉴定 核磁共振技术及应用, 主持, 省级, 2017-01--2019-12
（ 10 ） 基于肠-肝轴互作研究三氯生/三氯卡班的环境健康危害效应, 主持, 国家级, 2019-09--2022-12
（ 11 ） 基于药效物质基础研究的中药炮制标准化与中药开发, 参与, 省级, 2020-01--2022-12

（1）二噁英污染物环境暴露诱发肥胖的分子机理   第十届全国环境化学大会   张利民   2019-08-16
（2）基于NMR检测的代谢组学研究TCDF诱导非酒精性脂肪肝的分子机理   第二十届全国波谱学大会   2018-10-11
（3）Application of Metabolomics in Environmental Health   Limin Zhang   2018-08-24
（4）肠道菌群与四氯二苯并呋喃(TCDF)诱导的脂肪肝   第九届全国环境化学大会   2017-10-19
（5）In Vitro Biological Effects of Different Surface Modified Gold Nanorods: An NMR -based Metabolomics Study   2017-09-16
（6）Applications of Metabolomics in Environmental Health,   2017-04-20
（7）Gut microbiota contributes to TCDF-induced lipogenesis in mice   2016-07-01
（8）Metabolomics and its application in biological effects of gold nano-rods   2016-04-12
（9）The role of gut microbiota in the liver metabolic disorders induced by mild hepatic injury in mice   Limin Zhang, Emmanuel Hatzakis, Ruixin Hao, Robert G. Nichols, Jingwei Cai, Philip B. Smith, Gary H. Perdew, Frank J. Gonzalez, Andrew D. Patterson,    2015-03-23
（10）Aryl Hydrocarbon Receptor Activation by Persistent Organic Pollutants Impacts Gut Microbiota-Host Metabolic Homeostasis in Mice   3. Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, A   2014-03-22
（11）Systems Biological Responses of Rats to Aflatoxin B1 Exposure Revealed by Metabonomic NMR Analysis   L. M. Zhang, Y. Ye, Y. P. An, Y. L. Wang, H. R. Tang   2010-04-22
（12）Metabonomics methods development   Limin Zhang   2009-11-30
（13）Molecular Dynamics in the Semi-crystalline Poly(3-hydroxybutyrate) and Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) as Studied by Solid State NMR Spectroscopy   L. Zhang, H. Tang, G. Hou, Y. Shen, F. Deng,   2005-07-19

与北大医学部、武汉大学、华中科技大学、宾夕法尼亚州立大学等国内外著名高校建立了紧密的合作关系；与广东省金骏康生物技术有限公司、广西壮族自治区人民医院等单位在产学研和临床医学等方面建立了紧密的合作关系。

已指导学生

董满园  博士研究生  070302-分析化学  

郭阳阳  硕士研究生  085238-生物工程  

现指导学生

吴方  博士研究生  070302-分析化学  

陈桂  博士研究生  070302-分析化学  

曹政  硕士研究生  070302-分析化学  

陈川  博士研究生  070302-分析化学  

张策  硕士研究生  086000-生物与医药  

宋雨宸  博士研究生  070302-分析化学