基本信息
张利民  男  博导  中国科学院精密测量科学与技术创新研究院
电子邮件: zhanglm@wipm.ac.cn
通信地址: 武汉市武昌区小洪山西30号
邮政编码: 430071

研究领域

代谢组学和微生物组学结合免疫学研究肥胖和癌症等代谢性疾病以及衰老和骨质疏松等退行性病变的分子机制。

中药药效物质基础的多组学筛选和评价及其对代谢性疾病或退行性病变的防治。

招生信息

招收分析化学、生命科学、中药学等专业领域的研究生

招生专业
070302-分析化学
招生方向
色谱质谱分析、核磁共振分析
生物学、分析化学
中药学、微生物学

教育背景

2002-09--2007-06   中科院武汉物理与数学研究所   理学博士学位
1995-09--1999-07   华中师范大学   学士学位

工作经历

   
工作简历
2016-10~现在, 中科院武汉物理与数学研究所, 研究员,磁共振应用部副主任,生物医学代谢组学研究组组长
2012-02~2016-02,美国宾夕法尼亚州州立大学, Research fellow
2010-10~2016-10,中科院武汉物理与数学研究所, 副研究员
2007-07~2010-10,中科院武汉物理与数学研究所, 助理研究员
1999-07~2002-09,湖北省宜昌市第一中学, 中级化学教师
社会兼职
2018-12-30-2021-11-29,华中科技大学, 教授
2018-01-01-2019-12-31,《波谱学杂志》青年编委,

教授课程

磁共振前沿讲座

专利与奖励

   
奖励信息
(1) 中国科学院武汉分院优秀研究生指导教师, 院级, 2020
(2) 武汉市“3551”创新人才, 市地级, 2017
(3) 年度考核优秀, 研究所(学校), 2016
(4) 年度考核优秀, , 研究所(学校), 2011
(5) 年度考核优秀, , 研究所(学校), 2010
(6) 年度考核优秀, , 研究所(学校), 2009
(7) 优秀青年教师, 一等奖, 市地级, 2002
(8) 优秀青年教师, 一等奖, 市地级, 2001
专利成果
( 1 ) 纳米技术 纳米生物效应代谢组学方法 核磁共振波谱法, 实用新型, 2017, 第 1 作者, 专利号: GB/T-34059-2017

出版信息

   
发表论文
(1) Metabolomics safety assessments of microcystin exposure via drinking water in rats, Ecotoxicology and Environmental Safety, 2021, 通讯作者
(2) Gut Microbiota and Its Metabolite Deoxycholic Acid Contribute to Sucralose Consumption-Induced Nonalcoholic Fatty Liver Disease, J. Agric. Food Chem., 2021, 通讯作者
(3) Short-Term Intake of Hesperetin-7‑O‑Glucoside Affects Fecal Microbiota and Host Metabolic Homeostasis in Mice, J. Agric. Food Chem., 2021, 通讯作者
(4) A newly isolated bacterium Comamonas sp. XL8 alleviates the toxicity of cadmium exposure in rice seedlings by accumulating cadmium, Journal of Hazardous Materials, 2021, 通讯作者
(5) Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice, mSystems, 2021, 通讯作者
(6) Microbiome Analysis Combined with Targeted Metabolomics Reveal Immunological Anti-Tumor Activity of Icariside I in a Melanoma Mouse Model, Biomedicine & Pharmacotherapy, 2021, 通讯作者
(7) Quantitative measurement of a Chiral Drug in a Complex Matrix: A J‑Compensated Quantitative HSQC NMR Method, Anal. Chem., 2020, 通讯作者
(8) Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice, Environmental Pollution, 2020, 通讯作者
(9) Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice, Toxicology, 2020, 第 1 作者
(10) In Vitro Effects of Triclocarban on Adipogenesis in Murine Preadipocyte and Human Hepatocyte, Journal of Hazardous Materials, 2020, 通讯作者
(11) Dose-Dependent Effects of Triclocarban Exposure on Lipid Homeostasis in Rats, Chem. Res. Toxicol, 2019, 通讯作者
(12) Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats, J. Agric. Food. Chem., 2018, 通讯作者
(13) Colon Ascendens Stent Peritonitis (CASP) Induces Excessive Inflammation and Systemic Metabolic Dysfunction in a Septic Rat Model, J. Proteome Res., 2018, 通讯作者
(14) Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer, Cell, 2018, 第 8 作者
(15) Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice, J. Proteome Res., 2018, 第 3 作者
(16) Multiplatform Physiologic and Metabolic Phenotyping Reveals Microbial Toxicity, mSystem, 2018, 第 5 作者
(17) Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism, J. Proteome Res., 2018, 第 4 作者
(18) The aryl hydrocarbon receptor as a moderator of host-microbiota communication, Current Opinion in Toxicology, 2017, 第 1 作者
(19) A prenatal interruption of DISC1 function in the brain exhibits a lasting impact on adult behaviors, brain metabolism, and interneuron development, Oncotarget, 2017, 通讯作者
(20) Biological effects of amphiphilic copolymer nanoparticle-encapsulated multi-target chemotherapeutic drugs on MCF-7 human breast cancer cells, Metabolomics, 2017, 第 2 作者
(21) Orthogonal Comparison of GC-MS and 1H NMR Spectroscopy for Short Chain Fatty Acid Quantitation, Analytical Chemistry, 2017, 第 4 作者
(22) Fusarium oxysporum mediates systems metabolicreprogramming of chickpea roots as revealed by acombination of proteomics and metabolomics, Plant Biotechnology Journal, 2016, 第 1 作者
(23) Antioxidant Drug Tempol Promotes Functional Metabolic Changes inthe Gut Microbiota, J. Proteome Res., 2016, 第 2 作者
(24) Perfluorooctane Sulfonate-Choline Ion Pair Formation:A Potential Mechanism Modulating Hepatic Steatosisand Oxidative Stress in Mice, Toxiciology Sciences, 2016, 第 1 作者
(25) Expression of the aryl hydrocarbonreceptor contributes to theestablishment of intestinalmicrobial community structure inmice, Scitific Reports, 2016, 第 3 作者
(26) Farnesoid X Receptor Signaling Shapesthe Gut Microbiota and Controls HepaticLipid Metabolism, mSystems, 2016, 第 1 作者
(27) NMR-Based Metabolomics and Its Application in DrugMetabolism and Cancer Research, Curr Pharmacol Rep, 2016, 第 1 作者
(28) The Aryl Hydrocarbon Receptor as a Modulator of Host-MicrobiotaInteraction, Current Opinion Toxicology, 2016, 第 1 作者
(29) Reversing methanogenesis to capturemethane for liquid biofuel precursors, Microb Cell Fact, 2016, 第 4 作者
(30) Microbiota-Dependent Hepatic Lipogenesis Mediatedby Stearoyl CoA Desaturase 1 (SCD1)Promotes Metabolic Syndrome in TLR5-Deficient Mice, Cell Metabolism, 2015, 第 3 作者
(31) Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation byEnvironmental Chemicals Induces Systemic Metabolic Dysfunction inMice, Environmental Sciences & Technology., 2015, 第 1 作者
(32) Quantitative Analysis of Purine Nucleotides Reveals Purinosomes Increase de Novo Purine Biosynthesis, Journal of Biological Chemistry, 2015, 第 3 作者
(33) Persistent Organic Pollutants Modify Gut Microbiota–Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation, Environmental Health Perspective, 2015, 第 1 作者
(34) Intestinal farnesoid X receptor signaling promotes non-alcoholic fatty liver disease, Journal of Clinical Investigation, 2015, 第 4 作者
(35) Combined NMR and GC?MS Analyses Revealed Dynamic Metabolic Changes Associated with the Carrageenan-Induced Rat Pleurisy, J. Proteome Res. , 2015, 第 2 作者
(36) Metabonomic Analysis Reveals Efficient Ameliorating Effects of Acupoint Stimulations on the Menopause-caused Alterations in Mammalian Metabolism, Scitific Reports , 2014, 第 1 作者
(37) Dynamic metabolomic responses of Escherichia coli to nicotine stress, Canadian Journal of Microbiolo, 2014, 通讯作者
(38) Selective metabolic effects of gold nanorods on normal and cancer cells and their application in anticancer drug screening, Biomaterials, 2013, 第 1 作者
(39) Rapid Diagnosis and Prognosis of de novo Acute Myeloid Leukemia by Serum Metabonomic Analysis, J. Proteome Res. , 2013, 第 1 作者
(40) Metabolic Phenotypes Associated with High-Temperature Tolerance of Porphyra haitanensis Strains, J. Agric. Food Chem. , 2013, 第 2 作者
(41) , High-Fat Diet Induces Dynamic Metabolic Alterations in Multiple Biological Matrices of Rats, J. Proteome Res. , 2013, 通讯作者
(42) Combined NMR and GC?MS Analyses Revealed Dynamic Metabolic Changes Associated with the Carrageenan-Induced Rat Pleurisy, J. Proteome Res. , 2013, 通讯作者
(43) Nano-cellulose 3D-networks as controlled-release drug carriers, J. Mater. Chem. B, 2013, 通讯作者
(44) Global metabolomic responses of E. coli HB101 to heat stress, J. Proteome Res., 2012, 第 2 作者
(45) Age-Related Topographical Metabolic Signatures for the Rat Gastrointestinal Contents, J. Proteome Res., 2012, 第 2 作者
(46) Unraveling the concentration-dependent metabolic response of Pseudomonas sp. HF-1 to nicotine stress by 1H NMR-based metabolomics, Ecotoxicology, 2012, 第 3 作者
(47) Comprehensive Solid-State NMR Analysis Reveals the Effects of N-methylation on the Molecular Dynamics of Glycine, J. Phys. Chem. B, 2012, 第 3 作者
(48) Systems Biological Responses of Rats to Aflatoxin B1 Exposure Revealed by Metabonomic NMR Analysis, J. Proteome Res., 2011, 第 1 作者
(49) Understanding the Molecular Dynamics Associated with Polymorphic Transitions of dl-Norvaline with Solid-State NMR Methods, J. Phys. Chem. B, 2011, 第 4 作者
(50) A solid-state NMR study of structure and segmental dynamics of poly(propylmethacrylheptaisobutyl-pss)-co-styrene nanocomposites, J Colloid and Interface Sci ., 2011, 第 2 作者
(51) Beyond the T1 limit: Quantitative measure- ment in solid state NMR,  Journal of the American Chemical Society, 2010, 第 3 作者
(52) An insight into the metabolic responses of ultra-small superparamagnetic particles of iron oxide using metabonomic analysis of biofluids, Nanotechnology , 2010, 第 3 作者
(53) NMR analysis of metabolite composition of Escherichia coli, Chinese Analytical Chemistry, 2010, 第 2 作者
(54) Solid State NMR Studies of the Structure and Mobility of Semi-crystalline Poly(3-hydroxybutyrate) and Poly(3-hydroxybutyrate-co-3-hydroxyvalerate), polymer, 2007, 第 1 作者
(55) Interactions between Nafion Resin and Protonated Dodecylamine Modified Montmorillonite: A Solid State NMR Study, J Colloid and Interface Sci, 2007, 第 1 作者

科研活动

   
科研项目
( 1 ) 典型代谢物分子动力学与结构依赖性的固体NMR研究, 主持, 国家级, 2010-01--2013-06
( 2 ) 黄曲霉毒素毒性和致病机理及药物的预防作用, 主持, 部委级, 2008-01--2010-01
( 3 ) 有害物质引发动物应答的代谢组变化研究, 参与, 国家级, 2009-01--2013-12
( 4 ) 转基因小麦快速甄别与检测技术, 参与, 国家级, 2009-06--2011-12
( 5 ) 花生四烯酸及代谢组学研究, 参与, 国家级, 2010-01--2014-12
( 6 ) 基于宿主代谢和肠道菌群变化研究四氯二苯并呋喃诱导肥胖发生的分子机理, 主持, 国家级, 2016-01--2019-12
( 7 ) 基于质谱探针技术的模型鼠粪便代谢物全分析方法学研究, 参与, 国家级, 2017-01--2021-12
( 8 ) 基于宿主代谢和肠道菌群调节研究多环芳烃核受体AHR抑制改善肥胖的分子机理, 主持, 省级, 2017-01--2018-12
( 9 ) 特定位点同位素的食品真实性鉴定 核磁共振技术及应用, 主持, 省级, 2017-01--2019-12
( 10 ) 基于肠-肝轴互作研究三氯生/三氯卡班的环境健康危害效应, 主持, 国家级, 2019-09--2022-12
( 11 ) 基于药效物质基础研究的中药炮制标准化与中药开发, 参与, 省级, 2020-01--2022-12
参与会议
(1)二噁英污染物环境暴露诱发肥胖的分子机理   第十届全国环境化学大会   张利民   2019-08-16
(2)基于NMR检测的代谢组学研究TCDF诱导非酒精性脂肪肝的分子机理   第二十届全国波谱学大会   2018-10-11
(3)Application of Metabolomics in Environmental Health   Limin Zhang   2018-08-24
(4)肠道菌群与四氯二苯并呋喃(TCDF)诱导的脂肪肝   第九届全国环境化学大会   2017-10-19
(5)In Vitro Biological Effects of Different Surface Modified Gold Nanorods: An NMR -based Metabolomics Study   2017-09-16
(6)Applications of Metabolomics in Environmental Health,   2017-04-20
(7)Gut microbiota contributes to TCDF-induced lipogenesis in mice   2016-07-01
(8)Metabolomics and its application in biological effects of gold nano-rods   2016-04-12
(9)The role of gut microbiota in the liver metabolic disorders induced by mild hepatic injury in mice   Limin Zhang, Emmanuel Hatzakis, Ruixin Hao, Robert G. Nichols, Jingwei Cai, Philip B. Smith, Gary H. Perdew, Frank J. Gonzalez, Andrew D. Patterson,    2015-03-23
(10)Aryl Hydrocarbon Receptor Activation by Persistent Organic Pollutants Impacts Gut Microbiota-Host Metabolic Homeostasis in Mice   3. Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, A   2014-03-22
(11)Systems Biological Responses of Rats to Aflatoxin B1 Exposure Revealed by Metabonomic NMR Analysis   L. M. Zhang, Y. Ye, Y. P. An, Y. L. Wang, H. R. Tang   2010-04-22
(12)Metabonomics methods development   Limin Zhang   2009-11-30
(13)Molecular Dynamics in the Semi-crystalline Poly(3-hydroxybutyrate) and Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) as Studied by Solid State NMR Spectroscopy   L. Zhang, H. Tang, G. Hou, Y. Shen, F. Deng,   2005-07-19

合作情况

与北大医学部、武汉大学、华中科技大学、宾夕法尼亚州立大学等国内外著名高校建立了紧密的合作关系;与广东省金骏康生物技术有限公司、广西壮族自治区人民医院等单位在产学研和临床医学等方面建立了紧密的合作关系。

指导学生

已指导学生

董满园  博士研究生  070302-分析化学  

郭阳阳  硕士研究生  085238-生物工程  

现指导学生

吴方  博士研究生  070302-分析化学  

陈桂  博士研究生  070302-分析化学  

曹政  硕士研究生  070302-分析化学  

陈川  博士研究生  070302-分析化学  

张策  硕士研究生  086000-生物与医药  

宋雨宸  博士研究生  070302-分析化学